Pub Date : 2023-10-02DOI: 10.3389/fnano.2023.1271009
Francesco Roncari, Salimar Cordero, Cloé Desmet, Pascal Colpo, Boris L. T. Lau, Andrea Valsesia
Among the physical and chemical properties of nanomaterials, hydrophobicity is considered to play a key role in their impact on the environment. Changes in hydrophobicity resulting from abiotic and biotic processes can be used to predict the behaviours of nanoparticles (NPs) in the environment (e.g., aggregation, toxicity, and bioaccumulation). Hydrophobicity changes induced by sulfidation and natural organic matter (NOM) corona formation were evaluated by monitoring the binding rate of silver (Ag) NPs on engineered surfaces using dark-field microscopy (DFM). It was found that this DFM-based method was more capable of distinguishing the hydrophobicity of environmentally relevant AgNPs than the dye adsorption method. Under the conditions tested in this study, sulfidation and adsorption of sulfidized NOM/“lipid-free” (LF-)NOM increased the hydrophobicity of AgNPs. Both methods demonstrate the tendency of AgNPs to become more hydrophobic after sulfidation. This study shows that DFM-based methods can effectively measure the hydrophobicity of environmentally relevant NPs and have the potential to be widely used as fate predictors in the future.
{"title":"Direct quantification of hydrophobicity: a case study of environmentally relevant silver nanoparticles","authors":"Francesco Roncari, Salimar Cordero, Cloé Desmet, Pascal Colpo, Boris L. T. Lau, Andrea Valsesia","doi":"10.3389/fnano.2023.1271009","DOIUrl":"https://doi.org/10.3389/fnano.2023.1271009","url":null,"abstract":"Among the physical and chemical properties of nanomaterials, hydrophobicity is considered to play a key role in their impact on the environment. Changes in hydrophobicity resulting from abiotic and biotic processes can be used to predict the behaviours of nanoparticles (NPs) in the environment (e.g., aggregation, toxicity, and bioaccumulation). Hydrophobicity changes induced by sulfidation and natural organic matter (NOM) corona formation were evaluated by monitoring the binding rate of silver (Ag) NPs on engineered surfaces using dark-field microscopy (DFM). It was found that this DFM-based method was more capable of distinguishing the hydrophobicity of environmentally relevant AgNPs than the dye adsorption method. Under the conditions tested in this study, sulfidation and adsorption of sulfidized NOM/“lipid-free” (LF-)NOM increased the hydrophobicity of AgNPs. Both methods demonstrate the tendency of AgNPs to become more hydrophobic after sulfidation. This study shows that DFM-based methods can effectively measure the hydrophobicity of environmentally relevant NPs and have the potential to be widely used as fate predictors in the future.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135899715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 2006, Whitesides, writing about microfluidics, said that microfluidics is in early adolescence and it is not yet clear how it will develop. Today, almost 20 years later, microfluidics became a fully developed, highly sophisticated, multidisciplinary field that had entirely honoured its early promise. Its strength stems from the knowledge and know-how, coming from multiple disciplines such as physics of fluids, engineering, and microfabrication in the beginning, followed, more recently, by cell biological research, in full bloom nowadays. In microfluidic devices, the environment of cells such as chemical and mechanical gradients can be reproduced, making biological studies even more compelling. The red thread of this review paper follows the new insights and discoveries in both traditional macro- and microfluidic cell culture brought into the cell biology field, especially in the culture of stem cells, filled with promise in the field of regenerative medicine. Microfluidic devices provide an environment that is much closer to that of in vivo cell culture than the conventional culture platforms, where large amounts of cells are cultured and the environment of individual cells cannot be distinguished. The convenience of live cell imaging, portability, and the integration of sensors to precisely, control various parameters, has expanded cell biologists’ arsenal In addition, microfluidic devices, integrated with different functionalities, that is, the automated cell culture systems, will be discussed as well.
{"title":"Culturing cells for life: innovative approaches in macroscopic and microfluidic cultures, with an emphasis on stem cells","authors":"Simona Badilescu, Subhathirai Subramaniyan Parimalam, Muthukumaran Packirisamy","doi":"10.3389/fnano.2023.1264498","DOIUrl":"https://doi.org/10.3389/fnano.2023.1264498","url":null,"abstract":"In 2006, Whitesides, writing about microfluidics, said that microfluidics is in early adolescence and it is not yet clear how it will develop. Today, almost 20 years later, microfluidics became a fully developed, highly sophisticated, multidisciplinary field that had entirely honoured its early promise. Its strength stems from the knowledge and know-how, coming from multiple disciplines such as physics of fluids, engineering, and microfabrication in the beginning, followed, more recently, by cell biological research, in full bloom nowadays. In microfluidic devices, the environment of cells such as chemical and mechanical gradients can be reproduced, making biological studies even more compelling. The red thread of this review paper follows the new insights and discoveries in both traditional macro- and microfluidic cell culture brought into the cell biology field, especially in the culture of stem cells, filled with promise in the field of regenerative medicine. Microfluidic devices provide an environment that is much closer to that of in vivo cell culture than the conventional culture platforms, where large amounts of cells are cultured and the environment of individual cells cannot be distinguished. The convenience of live cell imaging, portability, and the integration of sensors to precisely, control various parameters, has expanded cell biologists’ arsenal In addition, microfluidic devices, integrated with different functionalities, that is, the automated cell culture systems, will be discussed as well.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-19DOI: 10.3389/fnano.2023.1249648
Akihiro Ishihara, Godai Miyaji
We report the fine periodic nanostructure formation process on metal and semiconductor surfaces in air with few-cycle 7-fs laser pulses and its physical mechanism. Using appropriate peak power densities and scanning speeds for the laser pulses, nanostructures could be formed on stainless steel and gallium arsenide (GaAs) with periods of 60–110 nm and 130–165 nm, respectively, which are 1/5–1/4 of the period of nanostructures formed with 100-fs laser pulses. The periodicity can be explained as arising from the excitation of short-range propagating surface plasmon polaritons, and the observed periods are in good agreement with the model calculation results.
{"title":"Fine periodic nanostructure formation on stainless steel and gallium arsenide with few-cycle 7-fs laser pulses","authors":"Akihiro Ishihara, Godai Miyaji","doi":"10.3389/fnano.2023.1249648","DOIUrl":"https://doi.org/10.3389/fnano.2023.1249648","url":null,"abstract":"We report the fine periodic nanostructure formation process on metal and semiconductor surfaces in air with few-cycle 7-fs laser pulses and its physical mechanism. Using appropriate peak power densities and scanning speeds for the laser pulses, nanostructures could be formed on stainless steel and gallium arsenide (GaAs) with periods of 60–110 nm and 130–165 nm, respectively, which are 1/5–1/4 of the period of nanostructures formed with 100-fs laser pulses. The periodicity can be explained as arising from the excitation of short-range propagating surface plasmon polaritons, and the observed periods are in good agreement with the model calculation results.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.3389/fnano.2023.1230407
Elham Ghazizadeh, Zahra Nasery
Biosensors are of significant importance today in the rapid, sensitive, and reliable detection of biological molecules in many fields, including medicine; owing to this fact, the development of a strong and reliable diagnostic agent is a very interesting topic. Because of their unique features, among other nanomaterials, lipid-based vesicles such as liposomes, exosomes, and microvesicles represent a type of biocompatible and versatile biosensing membrane surface for rapid biomarker detection and diagnosis of diseases, enhancing the assay sensitivity and decreasing the detection limit. In this review, we have reviewed the recent diagnostic application of lipid-based vesicles as biosensing substances in both conventional and novel techniques for identifying targets, especially in medicine and biotechnology sciences. Eventually, we have highlighted several recent promising developments in a new generation of biosensors based on liposome–nanomaterial hybrids and exosomes for analyzing targets and possible further advances in the future.
{"title":"The viewpoint of nanolipid vesicles (liposomes, exosomes, and microvesicles) as biosensors in medical health advances","authors":"Elham Ghazizadeh, Zahra Nasery","doi":"10.3389/fnano.2023.1230407","DOIUrl":"https://doi.org/10.3389/fnano.2023.1230407","url":null,"abstract":"Biosensors are of significant importance today in the rapid, sensitive, and reliable detection of biological molecules in many fields, including medicine; owing to this fact, the development of a strong and reliable diagnostic agent is a very interesting topic. Because of their unique features, among other nanomaterials, lipid-based vesicles such as liposomes, exosomes, and microvesicles represent a type of biocompatible and versatile biosensing membrane surface for rapid biomarker detection and diagnosis of diseases, enhancing the assay sensitivity and decreasing the detection limit. In this review, we have reviewed the recent diagnostic application of lipid-based vesicles as biosensing substances in both conventional and novel techniques for identifying targets, especially in medicine and biotechnology sciences. Eventually, we have highlighted several recent promising developments in a new generation of biosensors based on liposome–nanomaterial hybrids and exosomes for analyzing targets and possible further advances in the future.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135437800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.3389/fnano.2023.1270474
Marguerite R. Butler, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper
This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS). Novel spatially resolved instrumentation for spectral acquisition and subsequent statistical analysis for hot spot selection was developed for convenient quantification of TFV in an aqueous matrix. Methods of statistical analysis include the use of partial least squares (PLS) regression vector analysis and spectral ranking by quality indices computed using CHAOS theory. Hydroxylamine-reduced Ag colloidal nanoparticles evaporated to dryness on an aluminum well-plate were used as the SERS substrate. To our knowledge, quantification of TFV down to 25 ng/mL by SERS, comprising clinically relevant concentrations, has not been previously reported. Furthermore, in this work we propose a novel method of quantification of aqueous TFV standards by SERS using statistical treatment of data by PLS and CHAOS theory. Based on these data, we propose future studies to develop a method of TFV detection and quantification in biological samples, beneficial to clinicians for rapid assessment of drug adherence during the treatment and prevention of viral diseases.
{"title":"Detection and quantification of antiviral drug tenofovir using silver nanoparticles and surface enhanced Raman spectroscopy (SERS) with spatially resolved hotspot selection","authors":"Marguerite R. Butler, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper","doi":"10.3389/fnano.2023.1270474","DOIUrl":"https://doi.org/10.3389/fnano.2023.1270474","url":null,"abstract":"This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS). Novel spatially resolved instrumentation for spectral acquisition and subsequent statistical analysis for hot spot selection was developed for convenient quantification of TFV in an aqueous matrix. Methods of statistical analysis include the use of partial least squares (PLS) regression vector analysis and spectral ranking by quality indices computed using CHAOS theory. Hydroxylamine-reduced Ag colloidal nanoparticles evaporated to dryness on an aluminum well-plate were used as the SERS substrate. To our knowledge, quantification of TFV down to 25 ng/mL by SERS, comprising clinically relevant concentrations, has not been previously reported. Furthermore, in this work we propose a novel method of quantification of aqueous TFV standards by SERS using statistical treatment of data by PLS and CHAOS theory. Based on these data, we propose future studies to develop a method of TFV detection and quantification in biological samples, beneficial to clinicians for rapid assessment of drug adherence during the treatment and prevention of viral diseases.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135884343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-07DOI: 10.3389/fnano.2023.1243056
Alexandra Paxinou, Elena Marcello, Vittoria Vecchiato, Lara Erman, Edward Wright, Brendon Noble, Adele McCormick, Pooja Basnett
Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a polyhydroxyalkanoate (PHA) producer. A cell-free bacterial supernatant, which is typically discarded after PHA extraction, was used to produce spherical AuNPs of 3.5 ± 1.5 nm in size as determined by Transmission Electron Microscopy (TEM) analysis. The AuNPs/PHA composite coating demonstrated antibacterial activity against Staphylococcus aureus 6538P, and antiviral activity, with a 75% reduction in viral infectivity against SARS-CoV-2 pseudotype virus.
{"title":"Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles","authors":"Alexandra Paxinou, Elena Marcello, Vittoria Vecchiato, Lara Erman, Edward Wright, Brendon Noble, Adele McCormick, Pooja Basnett","doi":"10.3389/fnano.2023.1243056","DOIUrl":"https://doi.org/10.3389/fnano.2023.1243056","url":null,"abstract":"Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a polyhydroxyalkanoate (PHA) producer. A cell-free bacterial supernatant, which is typically discarded after PHA extraction, was used to produce spherical AuNPs of 3.5 ± 1.5 nm in size as determined by Transmission Electron Microscopy (TEM) analysis. The AuNPs/PHA composite coating demonstrated antibacterial activity against Staphylococcus aureus 6538P, and antiviral activity, with a 75% reduction in viral infectivity against SARS-CoV-2 pseudotype virus.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44892847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-04DOI: 10.3389/fnano.2023.1236810
A. Sanna, A. Quarta, N. Pieroni, B. Parodi, F. Palermo, I. Bukreeva, M. Fratini, L. Massimi, D. Simeone, X. Le Guével, A. Bravin, E. Quintiero, I. Viola, G. Gigli, N. Kerlero de Rosbo, L. Sancey, A. Cedola
Introduction: In the study of neurodegenerative diseases, the possibility to follow the fate of specific cells or molecules within the whole body would be a milestone to better understand the complex evolution of disease mechanisms and to monitor the effects of therapies. The techniques available today do not allow the visualization of disease-relevant cells within the whole tridimensional biological context at high spatial resolution.Methods: Here we show the results from the first validation steps of a novel approach: by combining the conjugate nanobodies anti-glial fibrillary acidic protein (GFAP) and metal-nanoparticles (i.e. 2 nm gold NP) with X-ray phase contrast tomography (XPCT) we would be able to obtain a tridimensional visualization and identification of cells of interest together with the surrounding tissue and the vascular and neuronal networks.Results: By exploiting the X-ray attenuation properties of metal nanoparticles and the specific targeting capabilities of nanobodies, we could give XPCT the specificity it presently lacks, making it no longer a pure morphological but a molecular and targeted imaging technique. In our case, we synthesized and characterized Gold-NP/GFAP nanobody to target the astrocytes of mouse brain.Discussion: The results of the first tests presented in this paper have provided us with information on the feasibility of the approach, encouraging us to carry out further experiments in order to achieve the ultimate goal of setting up this new imaging technique.
{"title":"Combining metal nanoparticles and nanobodies to boost the biomedical imaging in neurodegenerative diseases","authors":"A. Sanna, A. Quarta, N. Pieroni, B. Parodi, F. Palermo, I. Bukreeva, M. Fratini, L. Massimi, D. Simeone, X. Le Guével, A. Bravin, E. Quintiero, I. Viola, G. Gigli, N. Kerlero de Rosbo, L. Sancey, A. Cedola","doi":"10.3389/fnano.2023.1236810","DOIUrl":"https://doi.org/10.3389/fnano.2023.1236810","url":null,"abstract":"Introduction: In the study of neurodegenerative diseases, the possibility to follow the fate of specific cells or molecules within the whole body would be a milestone to better understand the complex evolution of disease mechanisms and to monitor the effects of therapies. The techniques available today do not allow the visualization of disease-relevant cells within the whole tridimensional biological context at high spatial resolution.Methods: Here we show the results from the first validation steps of a novel approach: by combining the conjugate nanobodies anti-glial fibrillary acidic protein (GFAP) and metal-nanoparticles (i.e. 2 nm gold NP) with X-ray phase contrast tomography (XPCT) we would be able to obtain a tridimensional visualization and identification of cells of interest together with the surrounding tissue and the vascular and neuronal networks.Results: By exploiting the X-ray attenuation properties of metal nanoparticles and the specific targeting capabilities of nanobodies, we could give XPCT the specificity it presently lacks, making it no longer a pure morphological but a molecular and targeted imaging technique. In our case, we synthesized and characterized Gold-NP/GFAP nanobody to target the astrocytes of mouse brain.Discussion: The results of the first tests presented in this paper have provided us with information on the feasibility of the approach, encouraging us to carry out further experiments in order to achieve the ultimate goal of setting up this new imaging technique.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47689320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.3389/fnano.2023.1259648
Dilpreet Singh, Supriya Ray
Nanodiamonds have emerged as a powerful tool in the field of drug delivery, offering exciting recent advancements and promising future prospects. Recent research has focused on enhancing drug loading efficiency, targeted delivery, and precision medicine using nanodiamonds. Strategies such as surface functionalization, polymer coatings, and encapsulation techniques have been optimized to improve drug loading, stability, and controlled release. Nanodiamonds have shown potential in targeted drug delivery through the incorporation of targeting ligands, enabling site-specific drug delivery and improved therapeutic outcomes. Additionally, nanodiamonds allow for combination therapy by carrying multiple drugs simultaneously, opening avenues for synergistic treatments. Stimuli-responsive nanodiamonds have been developed for precise and controlled drug release. Overcoming biological barriers, such as the blood-brain barrier, has been investigated by modifying nanodiamonds’ surfaces. Recent studies have highlighted innovative strategies for loading a variety of therapeutic cargoes onto nanodiamond platforms, including small molecules, proteins, nucleic acids, and even gene-editing tools. Future prospects include the integration of nanodiamonds with emerging technologies and addressing biocompatibility and safety concerns. Despite the need for further research and clinical studies, the recent advancements and future prospects of nanodiamonds in drug delivery suggest their potential to revolutionize the field and enhance patient care.
{"title":"A short appraisal of nanodiamonds in drug delivery and targeting: recent advancements","authors":"Dilpreet Singh, Supriya Ray","doi":"10.3389/fnano.2023.1259648","DOIUrl":"https://doi.org/10.3389/fnano.2023.1259648","url":null,"abstract":"Nanodiamonds have emerged as a powerful tool in the field of drug delivery, offering exciting recent advancements and promising future prospects. Recent research has focused on enhancing drug loading efficiency, targeted delivery, and precision medicine using nanodiamonds. Strategies such as surface functionalization, polymer coatings, and encapsulation techniques have been optimized to improve drug loading, stability, and controlled release. Nanodiamonds have shown potential in targeted drug delivery through the incorporation of targeting ligands, enabling site-specific drug delivery and improved therapeutic outcomes. Additionally, nanodiamonds allow for combination therapy by carrying multiple drugs simultaneously, opening avenues for synergistic treatments. Stimuli-responsive nanodiamonds have been developed for precise and controlled drug release. Overcoming biological barriers, such as the blood-brain barrier, has been investigated by modifying nanodiamonds’ surfaces. Recent studies have highlighted innovative strategies for loading a variety of therapeutic cargoes onto nanodiamond platforms, including small molecules, proteins, nucleic acids, and even gene-editing tools. Future prospects include the integration of nanodiamonds with emerging technologies and addressing biocompatibility and safety concerns. Despite the need for further research and clinical studies, the recent advancements and future prospects of nanodiamonds in drug delivery suggest their potential to revolutionize the field and enhance patient care.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46286525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.3389/fnano.2023.1256952
Sarmistha Saha, L. Saso
Advances in nanotechnology have attracted a lot of potential medical applications, such as therapeutic agents, diagnostics, and theranostics for complex diseases. The intersection of nanotechnologies, molecular and cell biology, and medicine can function to improve human health and quality of life, making healthcare a primary target of nanotechnology research. However, this seems like a promising future, ethical, health, and safety concerns must be considered before a reasoned evaluation of the situation can be made. Most nanostructures, however, typically fail to reach their intended targets because they get trapped inside innate immune cells. Since little is known about how nanomaterials and nanotechnologies change their identity inside the biological system, there is a wide-ranging discussion on possible concerns. In this regard, we present a perspective on how biological systems may interact with nanoscale materials and how that interaction might affect cellular recognition of nanostructures. We will also discuss dynamic modifications of the nanomaterials inside biological systems and, in particular, inflammation responses.
{"title":"Identity crisis of nanostructures inside the human body: a perspective on inflammation","authors":"Sarmistha Saha, L. Saso","doi":"10.3389/fnano.2023.1256952","DOIUrl":"https://doi.org/10.3389/fnano.2023.1256952","url":null,"abstract":"Advances in nanotechnology have attracted a lot of potential medical applications, such as therapeutic agents, diagnostics, and theranostics for complex diseases. The intersection of nanotechnologies, molecular and cell biology, and medicine can function to improve human health and quality of life, making healthcare a primary target of nanotechnology research. However, this seems like a promising future, ethical, health, and safety concerns must be considered before a reasoned evaluation of the situation can be made. Most nanostructures, however, typically fail to reach their intended targets because they get trapped inside innate immune cells. Since little is known about how nanomaterials and nanotechnologies change their identity inside the biological system, there is a wide-ranging discussion on possible concerns. In this regard, we present a perspective on how biological systems may interact with nanoscale materials and how that interaction might affect cellular recognition of nanostructures. We will also discuss dynamic modifications of the nanomaterials inside biological systems and, in particular, inflammation responses.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41333032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.3389/fnano.2023.1260792
Bijayananda Panigrahi, Suresh K. Verma, Sourav Das, Abhishek Kumar
{"title":"Editorial: New generation nano-biomaterials and their potential application in drug delivery and bio-sensing","authors":"Bijayananda Panigrahi, Suresh K. Verma, Sourav Das, Abhishek Kumar","doi":"10.3389/fnano.2023.1260792","DOIUrl":"https://doi.org/10.3389/fnano.2023.1260792","url":null,"abstract":"","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44251997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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