Infection Epidemiology and Microbiology最新文献

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Isolation and Molecular Identification of Streptomyces spp. Producing Antibacterial Compounds from Iranian Soil 伊朗土壤中产抗菌化合物链霉菌的分离与分子鉴定

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.25

R. Moravej, Sahar Honarmand Jahromi, peyman Azad

引用次数: 0

Characteristics of Prophage Patterns and Virulence Gene Profiles among Methicillin-Resistant Staphylococcus aureus Isolates from Patients with Diabetic Foot Infections in a Referral Hospital in Tehran, Iran 伊朗德黑兰一家转诊医院糖尿病足感染患者中耐甲氧西林金黄色葡萄球菌原噬菌体模式和毒力基因谱的特征

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.15

F. Rahimi, Sanaz Khashei

，

引用次数: 0

Impact of IL-35 and presepsin on immunological, hematological, and biochemical parameters in COVID-19 patients IL-35和蛋白酶对COVID-19患者免疫、血液学和生化指标的影响

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.35

F. Al-Khikani, Zeytoon Abdulridha Alkhafaji

Backgrounds: Immune-inflammatory responses appear to play a key role in severe SARS-CoV-2 infections. Interleukin-35 (IL-35) and presepsin (PSN) are inhibitory cytokine and pro-inflammatory interleukin, which play a crucial role in the immune system modulation, respectively. Therefore, the study of IL-35 and PSN interaction with other parameters may be critical for managing patients with COVID-19. Material(s) and Method(s): A total of 125 severe/critical COVID-19 patients and 60 healthy persons as a control group were enrolled in this work. These patients were admitted to Marjan medical city and Al-Sadeq hospital in Iraq during February to August 2022 and diagnosed as severe cases depending on the SpO2 percentage according to the guidelines released by the National Health World. Anti-and pro-inflammatory cytokines (IL-35 and PSN) were detected by ELISA technique. Finding(s): Presepsin showed a positive correlation with admission to the respiratory care unit (RCU) (r=.022, p=.011). A negative correlation was found between presepsin and C-reactive protein (CRP) (r=.21, p=.018). Both PSN and IL-35 in biochemical tests showed a positive strong effect on glucose levels in COVID-19 patients (r=.234, p=.008 and r=.241, p=.007, respectively). IL-35 had a positive impact on alkaline phosphatase (ALP) (r=.28, p=.002). Hemoglobin (Hb) level showed a positive correlation with presepsin (r=.2, p=.02). Conclusion(s): This study confirms the growing evidence showing the direct role of regulatory pro-inflammatory cytokines in the development and control of COVID-19 through the interaction with other parameters.Copyright © 2023, TMU Press.

背景:免疫炎症反应似乎在严重的SARS-CoV-2感染中起关键作用。白细胞介素-35 (IL-35)和促炎白介素(PSN)分别是抑制细胞因子和促炎白介素，在免疫系统调节中起重要作用。因此，研究IL-35和PSN与其他参数的相互作用可能对COVID-19患者的管理至关重要。材料和方法:本研究共纳入125例COVID-19重症/危重症患者和60例健康人作为对照组。这些患者于2022年2月至8月在伊拉克的Marjan医疗城和Al-Sadeq医院住院，根据国民健康世界公布的指南，根据SpO2百分比诊断为重症病例。ELISA法检测抗炎和促炎细胞因子(IL-35、PSN)水平。发现:Presepsin与入住呼吸护理病房(RCU)呈正相关(r=。022年,p = .011)。presepsin与c反应蛋白(CRP)呈负相关(r=。21日,p = .018)。生化测试中PSN和IL-35对COVID-19患者血糖水平均有积极的强烈影响(r=。234, p =。和r=。241, p =。007年,分别)。IL-35对碱性磷酸酶(ALP)有正向影响(r=。28日,p = .002)。血红蛋白(Hb)水平与presepsin呈正相关(r=。2, p = .02点)。结论:本研究证实了越来越多的证据表明，调节性促炎细胞因子通过与其他参数的相互作用，直接参与COVID-19的发生和控制。版权所有©2023,TMU出版社。

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引用次数: 3

Review on Phytochemicals and Pharmacological Activities of Syzygium aromaticum 香薷植物化学成分及药理活性研究进展

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.87

Dr. Yahya Bin Abdullah Alrashdi, Dr. Mohammad Amzad Hossain

在

引用次数: 0

Diagnostic Role of Platelet-Lymphocyte Ratio and Platelet Parameters in COVID-19 Disease 血小板-淋巴细胞比值及血小板参数在COVID-19中的诊断作用

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.71

N. Ganesan, E. Thomas, Subba Rao tadury Madhukar, K. S., Lawanya G

Backgrounds: This study aimed to analyze the applicability of platelet parameters in assessing the severity of COVID-19 disease. Material(s) and Method(s): Patients with RT-PCR confirmed COVID-19 in the Pathology department of a tertiary care hospital in south India from June to December 2020 were included in this study. Clinical details and laboratory parameters of these patients were obtained. The difference between the studied variables in two groups was assessed using independent t-test. The optimum cut-off value of platelet to lymphocyte ratio (PLR) to differentiate between the tested groups was estimated using ROC (receiver operator curve) analysis. Finding(s): This study was conducted on 218 COVID-19 patients, of whom 17.9% showed thrombocytopenia at the time of admission. Among the hematological parameters, PLR, absolute lymphocyte count (ALC), platelet distribution width (PDW), D-dimer, and erythrocyte sedimentation rate (ESR) were significantly different between the ICU (intensive care unit) and non-ICU groups. Increased PLR values were associated with the disease severity. Conclusion(s): PLR could be used as an additional biomarker in assessing the severity of COVID-19 disease, and a cut-off value of 210.27 is optimal to differentiate severe COVID-19 disease from its mild and moderate forms with 79% specificity.Copyright © 2023, TMU Press.

背景:本研究旨在分析血小板参数在评估COVID-19疾病严重程度中的适用性。材料和方法:本研究纳入了2020年6月至12月印度南部一家三级医院病理科RT-PCR确诊的COVID-19患者。获得这些患者的临床细节和实验室参数。两组研究变量间的差异采用独立t检验。采用ROC (receiver operator curve)分析估计各组间血小板与淋巴细胞比值(PLR)的最佳临界值。发现:本研究纳入了218例COVID-19患者，其中17.9%在入院时出现血小板减少症。血液学指标中，ICU组与非ICU组PLR、绝对淋巴细胞计数(ALC)、血小板分布宽度(PDW)、d -二聚体、红细胞沉降率(ESR)差异有统计学意义。PLR值升高与疾病严重程度相关。结论:PLR可作为评估COVID-19疾病严重程度的额外生物标志物，截断值为210.27是区分COVID-19重症与轻、中度疾病的最佳值，特异性为79%。版权所有©2023,TMU出版社。

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引用次数: 0

Thromboembolic Manifestations in Hospitalized COVID-19 Patients in India- A Single-Centre Retrospective Study 印度住院COVID-19患者的血栓栓塞表现-一项单中心回顾性研究

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Infection Epidemiology and Microbiology

Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.79

Y. Chidambaram, C. J. Jenil Dhas, N. Abilash, Velammal Petchiappan, M. Alagesan

引用次数: 0

Using Single Multiplex PCR Reaction to Identify Candida Species in Vaginal isolates: Comparison between Phenotypic and Molecular Methods 用单次多重PCR反应鉴定阴道分离念珠菌种类:表型方法与分子方法的比较

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Infection Epidemiology and Microbiology

Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.337

Majid Zare-Bidaki, F. Ghasemi, N. Ghanbarzadeh, F. Noferesti, F. Nikoomanesh

引用次数: 0

Development of a New Epitope Immunogenic Structure Based on the Coronavirus Membrane Glycoprotein M Using Immunoinformatics Tools 利用免疫信息学工具构建冠状病毒膜糖蛋白M抗原表位免疫原性结构

Q4 Medicine

Infection Epidemiology and Microbiology

Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.365

S. Pirmoradi

Backgrounds: Although conventional therapies have played an essential role in the treatment of many diseases, emerging diseases require new treatment methods with less complications. Therefore, it is important to develop an effective vaccine for infections caused by the coronavirus to prevent mortality and create immunity the community. Material(s) and Method(s): In this research bioinformatics tools were used to design a vaccine against the M membrane protein of SARS-CoV-2. A total of 27 epitopes confined to B cells and MHC I and II alleles were structurally constructed in M protein for immune stimulation and antibody recognition which were used in the construction of a chimeric peptide vaccine. Finding(s): The vaccine was predicted to be a stable, antigenic, and non-allergenic compound. TRL5/vaccine complex analysis and docking simulation indicated a sufficiently stable binding with appropriated receptor activation. The immune response simulation following hypothetical immunization indicated the potential of this vaccine to stimulate the production of active and memory B cells, CD8 + T and, CD4 + T cells, and effective immunological responses induced by Th2 and Th1. Conclusion(s): The analysis of in-silico processes showed that the vaccine structure induced high antigenicity and good cellular immunity in the host body and stimulates various immune receptors such as TLR5, MHC I, and MHC II. Vaccine function was also associated with an increase in IgM and IgG antibodies and a set of Th1 and Th2 cytokines. But the final confirmation of the effectiveness of the designed vaccine requires clinical processes.Copyright © 2022, TMU Press.

背景:虽然传统疗法在许多疾病的治疗中发挥了至关重要的作用，但新出现的疾病需要新的治疗方法，并发症更少。因此，开发有效的新冠病毒感染疫苗对于预防死亡和创造社会免疫力至关重要。材料和方法:本研究利用生物信息学工具设计了一种针对SARS-CoV-2 M膜蛋白的疫苗。在M蛋白中构建了27个限定于B细胞和MHC I和II等位基因的表位，用于免疫刺激和抗体识别，用于构建嵌合肽疫苗。发现:该疫苗被预测为一种稳定的、抗原性的、非致敏性的化合物。TRL5/疫苗复合物分析和对接模拟表明，与适当受体激活的结合足够稳定。假设免疫后的免疫反应模拟表明，该疫苗有可能刺激活性和记忆B细胞、CD8 + T细胞和CD4 + T细胞的产生，以及Th2和Th1诱导的有效免疫反应。结论:计算机过程分析表明，该疫苗结构在宿主体内诱导了高抗原性和良好的细胞免疫，并刺激了TLR5、MHC I、MHC II等多种免疫受体。疫苗功能还与IgM和IgG抗体以及一组Th1和Th2细胞因子的增加有关。但是最终确认设计的疫苗的有效性需要临床过程。版权所有©2022,TMU出版社。

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引用次数: 0

Antibacterial Resistance and Virulence Potential of Avian Colibacillosis-Causing Escherichia coli Isolates 禽大肠杆菌病病原菌分离株的耐药性和毒力潜力

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Infection Epidemiology and Microbiology

Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.307

Z. Pourhossein, L. Asadpour, H. Habibollahi, Seyedeh Tooba Shafighi

引用次数: 0

Evaluating the Genetic Diversity of Helicobacter pylori Isolates in Patients Suffering from Gastritis 胃炎患者幽门螺杆菌分离株遗传多样性评价

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Infection Epidemiology and Microbiology

Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.297

Sanaz Mami, Saeedeh Khaleghnezhad, M. Mami, M. Dadashi, M. Goudarzi, Hossein Ghahremanpour, Bahareh Hajikhani

引用次数: 0

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