Mathematical models translate real-world problems into a structured framework, which makes it easier to investigate and analyze. Multi-patch compartmental models are used to model real-world scenarios related to epidemiology. Optimal control theory is used in this model to identify cost-effective strategies to minimize the proportion of individuals infected with COVID-19 in Sri Lanka. Since a nine-patch SIR-type model is considered in this research, human dispersal behaviors play a vital role. However, due to the lack of mobility data in Sri Lanka, a gravity model approach with a modified gravity model which models the human dispersal behaviors within and between patches is used to incorporate the human dispersal behaviors into the nine-patch SIR-type model. Then, the country is divided into three clusters using K-means clustering, based on the peak number of infections in each province without any control measures, for better representation. When using the control measure effective reproduction number represents the spread of the disease with sensitivity with the current susceptible population. It is observed that, in the absence of controls, decreases from 1.55 to 1.30 within 400 days, and that it decreases from 1.57 to 0 within 20 days in the presence of controls. Control measures such as health measures and vaccination can control the disease within 40, 30–40, and 20–30 days in high-risk, moderate, and low-risk regions, respectively. Furthermore, results suggest that vaccination is the most efficient control strategy since it minimizes disturbing the lives of the general community rather than public health measures.
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