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Time-Trend Analysis of Bladder Cancer and its Association with Bilhariziasis in Egypt 埃及癌症的时间趋势分析及其与血吸虫病的关系
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.496
S. Muter
Background: Both bladder cancer and schistosomiasis are endemic in Egypt. The former has a unique epidemiological pattern, which has been linked to bladder infestation by Schistosoma. The last decades have witnessed a great reduction in the infection rate of schistosomiasis and a decline in the incidence and changes in the patterns of bladder cancer. Whether these changes are linked to each other or a co-incidence is a subject of investigations.Method: Literature on epidemiological data of bladder cancer and Schistosoma in Egypt was searched for in Medline, Scopus, PubMed, and Google Scholar. Furthermore, a hand search for literature and reports released by the Egyptian government and involved agencies was performed.Results: Studies describe an overall reduction in Schistosoma infection rate from 80% in 1920s to 1.2% in 2006. Studies on bladder cancer epidemiology, on the other hand, agree on a decline in incidence and changes in the pattern, but differ in figures describing the magnitude of these changes. Many studies tried to ling the changes in Schistosoma and bladder cancer patterns. The evidence for this link, however, seems to be insufficient for a cause-and-effect relationship.Conclusion: The relationship between the reduction in schistosomiasis infection rate and the changes in bladder-cancer epidemiological pattern in Egypt cannot be overlooked, but needs to be proved by more reliable evidence like prospective studies that include local health facilities and tertiary cancer centers.Objective: explore the possible cause-and-effect relationship between the changes in Schistosoma infection rates and incidence and patterns of bladder cancer in Egypt.
背景:癌症和血吸虫病都是埃及的地方病。前者具有独特的流行病学模式,与血吸虫病的膀胱感染有关。在过去的几十年里,血吸虫病的感染率大大降低,癌症的发病率和发病模式也有所下降。这些变化是相互关联的还是共同发生的,有待调查。方法:在Medline、Scopus、PubMed和Google Scholar等网站上检索埃及癌症和血吸虫病流行病学资料。此外,还对埃及政府和有关机构发布的文献和报告进行了手工搜索。结果:研究表明,血吸虫病感染率从20世纪20年代的80%总体下降到2006年的1.2%。另一方面,对癌症流行病学的研究一致认为发病率下降和模式变化,但在描述这些变化幅度的数字上有所不同。许多研究试图阐明血吸虫病和膀胱癌症模式的变化。然而,这种联系的证据似乎不足以证明因果关系。结论:埃及血吸虫病感染率的降低与膀胱癌流行病学模式的变化之间的关系不容忽视,但需要通过更可靠的证据来证明,如包括当地卫生机构和三级癌症中心在内的前瞻性研究。目的:探讨埃及血吸虫病感染率的变化与癌症发生、发展模式的可能因果关系。
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引用次数: 1
Awareness Regarding Diabetes Risk Factors, Prevention and Management among Community Members in Diyala/Baqubah 迪亚拉/巴古拜社区成员对糖尿病危险因素、预防和管理的认识
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.272
Rania Ayad Abdul Karim, H. Habib
Background: Background: Diabetes mellitus is a life-threatening disease. Global prevalence of diabetes mellitus is increasing rapidly providing a worrying indication and major threat to global health unless interventions are created through community awareness and knowledge regarding different aspect of DM.Aims: To assess the level of awareness regarding diabetes risk factors, prevention and management among community members in Baqubah city and to identify any association between awareness level and some variables.Methods: Across sectional study was carried out from the 1st of January - 30th of November 2019 in all primary health care centers (six centers) in center of Baqubah city. A convenient sample of 400 participants who attended the health centers during the study period and eligible to inclusion criteria were included. Data were collected vie direct interview with a structural questionnaire that include personal data, questions regarding knowledge, regard diabetes definition, prevention, risk factor, management and control.Results: Good diabetes awareness were reported among 50% of studied. A significant statistical association were found between good awareness and age of 20-30years, more than secondary school education, high family income and positive family history of diabetes with the following (52, 34, 35 & 68) % respectively.Conclusion: Good diabetes awareness was dominant and was significantly associated with middle age group, higher education and positive family history of diabetes. an educational health programs that tackles area of weakness about awareness of diabetes mellitus need to be implemented on the governmental level.
背景:糖尿病是一种危及生命的疾病。除非通过社区对糖尿病不同方面的认识和知识进行干预,否则全球糖尿病患病率正在迅速上升,这对全球健康构成了令人担忧的指征和重大威胁。目的:评估对糖尿病危险因素的认识水平,Baqubah市社区成员的预防和管理,并确定意识水平与一些变量之间的任何关联。方法:于2019年1月1日至11月30日在巴古巴市中心的所有初级卫生保健中心(六个中心)进行横断面研究。纳入了一个方便的样本,400名参与者在研究期间参加了健康中心,符合入选标准。数据是通过结构问卷的直接访谈收集的,其中包括个人数据、知识问题、糖尿病定义、预防、风险因素、管理和控制。结果:50%的研究对象有良好的糖尿病意识。良好的意识与20-30岁的年龄、中学以上的教育程度、高家庭收入和糖尿病阳性家族史之间存在显著的统计相关性,分别为(52、34、35和68)%。结论:良好的糖尿病意识占主导地位,并与中年、高等教育和糖尿病家族史阳性显著相关。需要在政府层面实施一项教育健康计划,以解决糖尿病意识薄弱的领域。
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引用次数: 2
Spinal Tuberculosis in Children 儿童脊柱结核
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.790
Olim Zaribovich Akramov, Davron Bahtiyarovich Kadirov, L. Nazarova
Tuberculosis continues to be the leading cause of morbidity and mortality, with an estimated annual incidence of 10.4 million worldwide. It has been estimated that 10% of patients with extrapulmonary tuberculosis have musculoskeletal involvement, with the spine being the most common. Spinal tuberculosis (TB) accounts for 50% of cases of musculoskeletal tuberculosis. Spinal tuberculosis is the result of infection with Mycobacterium tuberculosis. It is a secondary infection, the primary lesion of which is in the lungs, genitourinary system, or gastrointestinal tract and can be active or latent. Involvement of the vertebral segment is the result of hematogenous spread of infection along the arterial pathway or Batson's vein plexus, lymphatic spread, or direct invasion from adjacent internal organs.  Computed tomography (CT) is better suited for assessing the extent of the lesion when contrast is used to enhance granulomatous tissues and abscesses, but exposes the patient to high radiation. Magnetic resonance imaging (MRI) can detect changes that occur in the early stages of the disease. WHO has suggested that any extrapulmonary tuberculosis should require sputum examination and chest x-ray, as there is a high risk of pulmonary infection. Thus, computed tomography (CT) and magnetic resonance imaging (MRI) are the main modalities for detecting tuberculous spondylitis.    
结核病仍然是发病率和死亡率的主要原因,全世界每年的发病率估计为1040万。据估计,10%的肺外结核患者有肌肉骨骼受累,其中脊椎最为常见。脊柱结核(TB)占肌肉骨骼结核病例的50%。脊柱结核是结核分枝杆菌感染的结果。它是一种继发性感染,主要病变在肺部、泌尿生殖系统或胃肠道,可以是活动性的,也可以是潜伏性的。椎段受累是感染沿动脉途径或巴特森静脉丛的血行扩散、淋巴扩散或邻近内脏直接侵袭的结果。当造影剂用于增强肉芽肿性组织和脓肿,但使患者暴露在高辐射下时,计算机断层扫描(CT)更适合评估病变的程度。磁共振成像(MRI)可以检测疾病早期发生的变化。世界卫生组织建议,任何肺外结核都应进行痰检和胸部x光检查,因为肺部感染的风险很高。因此,计算机断层扫描(CT)和磁共振成像(MRI)是检测结核性脊柱炎的主要方式。
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引用次数: 0
Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients 2型糖尿病与非糖尿病患者角膜内皮细胞计数的比较研究
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.799
M. G. AnNasseh, Saif Ibrahim Raheem, G. Neamah
Background: Diabetes mellitus is one of the commonest chronic disorders worldwide with a rapid rise in prevalence. In Iraq its prevalence is high especially in elderly age group. Patients with type 2 diabetes mellitus have higher vulnerability for complications, whether microvascular or macrovascular. Ocular complications are common in diabetes mellitus, and comprise diabetic retinopathy, diabetic papillopathy, cataract, glaucoma, dry eye disease and diabetic keratopathy. Diabetic keratopathy involves endothelial and epithelial tissues of the cornea, leading to persistent epithelial defect, corneal erosion, or corneal ulcers.Aim of the Study: To compare the mean corneal endothelial cell count between patients with type 2 diabetes mellitus and non-diabetics.Subjects and Methods: This is a case-control study conducted in Ibn Al Haitham Teaching Eye Hospital – Baghdad and included 249 participants, 125 cases with type 2 diabetes and 124 controls who had no diabetes. Endothelial cell count was measured for 1 eye of each participant using TOPCON® SP-3000P microscope. Patients who had diabetes for less than 5 years, and patients who had previous ocular surgery, injury or disorders were excluded.Results: There was a significant difference in endothelial cell count between cases with type 2 diabetes mellitus and controls; P = 0.001. There was also a significant negative correlation between age and endothelial cell count, R = -0.20, P = 0.002. Similarly, there was a significant negative correlation between duration of diabetes mellitus and endothelial cell count, R = -0.44, P < 0.001.Conclusions: Type 2 diabetes mellitus causes significant reduction in mean corneal endothelial cell count. There is also a negative correlation between corneal endothelial cell count and both age and duration of the disease.
背景:糖尿病是世界范围内最常见的慢性疾病之一,患病率迅速上升。在伊拉克,其发病率很高,尤其是在老年群体中。2型糖尿病患者更容易发生并发症,无论是微血管还是大血管并发症。眼部并发症在糖尿病中很常见,包括糖尿病视网膜病变、糖尿病乳头状瘤病、白内障、青光眼、干眼病和糖尿病角膜病变。糖尿病性角膜病变涉及角膜的内皮和上皮组织,导致持续的上皮缺损、角膜侵蚀或角膜溃疡。研究目的:比较2型糖尿病患者和非糖尿病患者的平均角膜内皮细胞计数。受试者和方法:这是一项在巴格达伊本·海塔姆教学眼科医院进行的病例对照研究,包括249名参与者、125名2型糖尿病病例和124名无糖尿病对照者。使用TOPCON®SP-3000P显微镜测量每个参与者1只眼睛的内皮细胞计数。患有糖尿病5年以下的患者,以及既往接受过眼部手术、损伤或疾病的患者均被排除在外。结果:2型糖尿病患者内皮细胞计数与对照组比较有显著性差异;P=0.001。年龄与内皮细胞计数之间也存在显著的负相关,R=-0.20,P=0.002。同样,糖尿病持续时间与内皮细胞计数呈显著负相关,R=-0.44,P<0.001。结论:2型糖尿病导致平均角膜内皮细胞计数显著降低。角膜内皮细胞计数与年龄和疾病持续时间之间也存在负相关。
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引用次数: 0
Potential Influence of Parasitic Diseases as Protective Agents from Infection with Pandemic COVID-19 寄生虫病作为保护剂对COVID-19感染的潜在影响
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.818
Israa Mohammad Abd AL-Khaliq
Parasitic diseases can affect infection with COVID-19 obviously, as protective agents, or by reducing severity of this viral infection. This current review mentions the common symptoms between human parasites and symptoms of COVID-19, and explains the mechanism actions of parasites, which may prevent or reduce severity of this viral infection. Pre-existing parasitic infections provide prohibition against pathogenicity of COVID-19, by altering the balance of gut microbiota that can vary the immune response to this virus infection.  
寄生虫病可以作为保护剂,或通过降低这种病毒感染的严重程度,明显影响新冠肺炎的感染。这篇最新综述提到了人类寄生虫与新冠肺炎症状之间的常见症状,并解释了寄生虫的机制作用,这可能会预防或降低这种病毒感染的严重程度。预先存在的寄生虫感染通过改变肠道微生物群的平衡,可以改变对这种病毒感染的免疫反应,从而禁止新冠肺炎的致病性。
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引用次数: 0
Surrogates Markers of Insulin Resistance 胰岛素抵抗的替代标记物
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.837
E. Hameed, Laith Thamer Al-Ameri
Insulin resistance is a fundamental feature of obesity, diabetes, and cardiovascular diseases and contributes to many of the metabolic syndrome's abnormalities. It is defined as a subnormal reaction to normal insulin concentrations or a situation in which greater than normal insulin concentrations are necessary for normal response.
胰岛素抵抗是肥胖、糖尿病和心血管疾病的一个基本特征,并导致许多代谢综合征的异常。它被定义为对正常胰岛素浓度的亚正常反应,或者正常反应需要高于正常胰岛素浓度。
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引用次数: 1
The Role of Strain Elastography in Evaluating Borderline Axillary Lymph nodes 应变弹性成像在评估腋窝交界淋巴结中的作用
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.692
A. Muhi, A. Kamal, S. Dawood, T. F. Kareem, Rasha Thameen Thameen Fakhri, Zaid Al-Attar
Background: Axillary lymph node (ALN) enlargement with diffuse cortical thickening and conserved echogenic hilum may represent a diagnostic and therapeutic challenge. Sonographic strain elastography may help the characterization of borderline ALN. Aim: To evaluate the strain elastography of borderline ALN and to calculate a cutoff value of strain ratio (SR) that can identify suspicious ALN with the highest sensitivity and specificity to reduce unnecessary invasive procedures. Subjects and Methods: A prospective study included 45 patients who attended the Breast clinic in Oncology Teaching Hospital with borderline axillary lymphadenopathy (intact hilum and diffusely thickened cortex more than 3mm) who had normal ipsilateral breast, suspicious ipsilateral breast lesion, or who had ipsilateral mastectomy. B-mode sonography and elastography were performed for all participants. Four-point elasticity score (ES), and SR were obtained for the targeted lymph node followed by ultrasound-guided fine need aspirate (FNA) biopsy..Results: Malignant ALN constituted 20% of the cohort. B mode measurements were not able to differentiate between cytologically confirmed benign and malignant ALN in terms of axis ratio (mean ± standard deviation, 0.46 ± 0.08 vs 0.50 ± 0.12) and cortical thickness (4.88 ± 1.93 vs 6.27 ± 2.46). The mean SR of all samples was 2.66 ± 2.25.  Metastatic ALN depicted significantly higher SR (P<0.0001), with 88.9% exhibiting ES score 3 and 4. None of the metastatic ALN had ES score 1. ROC curve was used to investigate the utility of SR as a diagnostic tool. The area under the curve (AUC) was 0.906 with a 95% CI of 0.814-0.997, P<0.001. SR cutoff of 2.1 was chosen with 100% sensitivity and 66.7% specificity.Conclusion: High proportion of borderline ALNs are not malignant. Strain elasticity can improve the risk stratification of such cases and prevent unnecessary invasive procedures. We suggested an algorithm that could better tackle borderline ALN which will need further evaluation
背景:腋窝淋巴结(ALN)肿大伴弥漫性皮质增厚和保守的回声门可能是诊断和治疗的挑战。超声应变弹性成像可能有助于边界ALN的表征。目的:评估边界ALN的应变弹性成像,并计算应变比(SR)的临界值,该值可以以最高的灵敏度和特异性识别可疑ALN,以减少不必要的侵入性手术。受试者和方法:一项前瞻性研究纳入了45名在肿瘤教学医院乳腺诊所就诊的边缘腋窝淋巴结病患者(门完整,皮质弥漫性增厚超过3mm),他们的同侧乳腺正常,同侧乳腺病变可疑,或进行了同侧乳房切除术。对所有参与者进行了B型超声和弹性成像。获得目标淋巴结的四点弹性评分(ES)和SR,然后进行超声引导的细针穿刺(FNA)活检。。结果:恶性ALN占队列的20%。B型测量无法在轴比(平均值±标准差,0.46±0.08 vs 0.50±0.12)和皮质厚度(4.88±1.93 vs 6.27±2.46)方面区分细胞学证实的良性和恶性ALN。所有样本的平均SR为2.66±2.25。转移性ALN的SR明显更高(P<0.0001),88.9%的患者ES评分为3和4。转移性ALN的ES评分均为1。ROC曲线用于研究SR作为诊断工具的效用。曲线下面积(AUC)为0.906,95%CI为0.814-0.997,P<0.001。选择2.1的SR临界值具有100%的敏感性和66.7%的特异性。结论:高比例的交界性ALN不是恶性的。应变弹性可以改善此类病例的风险分层,并防止不必要的侵入性手术。我们提出了一种算法,可以更好地处理需要进一步评估的边界ALN
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引用次数: 0
Assessment of Nurses’ Knowledge, Attitude, and Practices on Antibiotic Use and Resistance in Baghdad: A single-hospital study 巴格达护士对抗生素使用和耐药性的知识、态度和实践评估:一项单院研究
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.385
Kholod Dhaher Habib, Z. Jaber, Abbas Abboud Hassan
Background: There are so many evidences that there was antimicrobial resistance, and there were many strains that emerged which were difficult to treat. We are living in a situation that the dissemination of multiple drug resistant bacteria can lead us to the situation, in which no treatment could be offered for bacterial infection in future.Aim of study: Assessment of nurses’ knowledge, attitude, and practices on antibiotic use and resistance in Fatima Al Zahra hospital in Baghdad.Subjects and Methods:  A cross-sectional study. The study was carried on from 1st of February to 31st of March 2021.  A questionnaire was constructed by the research team based on literature review and was adapted to assess the nurses’ knowledge, attitude, and practices on antibiotic use and resistance in Fatima Al Zahra hospital. The adopted questions were mainly based on previous studies carried out in Lebanon, and Ethiopia. It was piloted among 10 nurses. The questionnaire was further revised by the research team. The final questionnaire contained 26 questions on the following: Demographics characteristics (5 questions), Knowledge of antibiotics (7 questions), Attitude towards antibiotic use (7 questions); and practice with regards to antibiotic use (7 questions). Analysis plan: IBM SPSS (Statistical Package for the Social Sciences) Statistics version 21 Multilingual and Microsoft Excel 2010 were used to analyze the data. The frequencies were stated first then Chi-Square test and Fisher’s exact test were used to investigate the association. The p-value less than 0.05 were considered significant.Results: One hundred and eight nurses participated in this study, of whom 101 (93.5%) were female, 31(28.7%) of participants at the age group of (18-27) years, 33(30.6%) were at the age group of (28-37) years, with mean age 26± 0.54 SD. Regarding the highest qualification, 41(38%) graduated from the high school of nursing, 35(32.4%) graduated from the midwife school. About 46(42.6%) of the participants were working in pediatric words, and 23(21.3%) were working in gynecology and obstetrics (Gyn & Obs) words. There was gap in the knowledge especially in nurses who had lowest qualification: 44(40%), of them believe that using antibiotic in cold can speed recovery and 41 (38%) believe that antibiotic can cure viral infections, and 42(38.9%), of them consider that newer and more costly antibiotics affect better.Conclusion: There was a gap in nurse’s knowledge, and practice, towards the antibiotic use and antibiotic resistance, the Current work place was the most effective factor in this gap.
背景:有很多证据表明存在耐药性,并且出现了许多难以治疗的菌株。我们生活在一种情况下,多种耐药细菌的传播可能会导致我们陷入这样的境地,即未来无法为细菌感染提供治疗。研究目的:评估巴格达Fatima Al-Zahra医院护士对抗生素使用和耐药性的知识、态度和实践。受试者和方法:横断面研究。该研究于2021年2月1日至3月31日进行。研究小组根据文献综述编制了一份问卷,用于评估Fatima Al-Zahra医院护士对抗生素使用和耐药性的知识、态度和做法。所通过的问题主要基于先前在黎巴嫩和埃塞俄比亚进行的研究。它在10名护士中进行了试点。研究小组对问卷进行了进一步修订。最终问卷包含26个问题:人口学特征(5个问题)、抗生素知识(7个问题)和对抗生素使用的态度(7个问);以及关于抗生素使用的实践(7个问题)。分析计划:使用IBM SPSS(社会科学统计软件包)Statistics version 21 Multilingual和Microsoft Excel 2010对数据进行分析。首先说明频率,然后使用卡方检验和Fisher精确检验来研究这种关联。p值小于0.05被认为是显著的。结果:108名护士参与了这项研究,其中101名(93.5%)为女性,31名(28.7%)为(18-27)岁年龄组,33名(30.6%)为(28-37)岁年龄段,平均年龄为26±0.54 SD。在最高学历方面,41名(38%)毕业于护理高中,35名(32.4%)毕业于助产士学校。约46名(42.6%)参与者从事儿科词汇工作,23名(21.3%)参与者从事妇产科词汇工作。在知识方面存在差距,尤其是资质最低的护士:44人(40%)认为在感冒时使用抗生素可以加快康复,41人(38%)认为抗生素可以治愈病毒感染,42人(38.9%)认为更新、更昂贵的抗生素效果更好。结论:护士在抗生素使用和耐药性方面的知识和实践存在差距,目前的工作场所是造成这一差距的最有效因素。
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引用次数: 0
A serology conundrum – HIV infection in acute babesiosis infection could merely be a false positive result 一个血清学难题——急性巴贝斯病感染中的HIV感染可能仅仅是一个假阳性结果
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.280
Rand Hindosh, E. Ernst, J. Kamau, Steven Cardio
Babesiosis is a tick-borne disease caused by Babesia microti. We present a case of false positive HIV in the setting of confirmed babesiosis infection. An understanding that patients with babesiosis can have a false positive HIV test result is important in management decisions. 
巴贝斯虫病是由微小巴贝斯虫引起的一种蜱传疾病。我们提出一个病例假阳性艾滋病毒在确定巴贝斯虫病感染的设置。了解巴贝斯虫病患者可能有假阳性艾滋病毒检测结果是重要的管理决策。
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引用次数: 1
Possible role of Spironolactone in a sample of Iraqi patients with acute central serous chorioretinopathy 螺内酯在伊拉克急性中心性浆液性脉络膜视网膜病变患者样本中的可能作用
Pub Date : 2022-05-05 DOI: 10.47723/kcmj.v18i1.668
Marwa Majeed Hameed, A. Rasheed, Furkaan Majeed Hameed
Background: Central serous chorioretinopathy (CSCR) is an idiopathic condition aggravated by exogenous or endogenous glucocorticoids. Vascular deregulation in the choroid is a new hypothesis regarding central serous chorioretinopathy occurrence. The inhibition of choroidal mineralocorticoid receptors has a great role in shortening the duration of CSCR by inhibiting choroidal vasodilatation and leak.Objective:  To assess the effect of oral spironolactone on subretinal fluid, central macular thickness and visual acuity in patients with acute CSCR compared to observation.Subjects and Methods:  a hospital based, randomized clinical trial carried out at outpatient clinic in Ibn-Alhaitham Teaching Eye Hospital/ Baghdad, enrolling 60 patients with acute unilateral CSCR, allocated randomly (every other patient) to either receiving spironolactone 25 mg orally, twice daily for 2 months (30 patients) or observation only (30 patients). The follow-up included visual acuity measurement, central macular thickness and subretinal fluid height examinations by ocular coherence tomography (OCT) at one- and two-months post enrollment for all patients.Results: Complete absorption of subretinal fluid was observed in 21(70%) of the eyes in the treatment group and in 6(20%) in the control group at two-months. Visual acuity and mean macular thickness improved significantly in both groups at the one- and two- months, mean changes was larger in treatment group compared to control group at the two-month-follow up endpoint.Conclusion: Oral spironolactone imparted greater improvement in central macular thickness and faster resolution of sub retinal fluid in patients with acute central serous chorioretinopathy versus observation.
背景:中心性浆液性脉络膜视网膜病变(CSCR)是一种由外源性或内源性糖皮质激素加重的特发性疾病。脉络膜血管失调是关于中心性浆液性脉络膜视网膜病变发生的一个新假说。脉络膜盐皮质激素受体的抑制通过抑制脉络膜血管舒张和渗漏在缩短CSCR的持续时间方面具有重要作用。目的:比较口服螺内酯对急性CSCR患者视网膜下液、黄斑中央厚度和视力的影响。受试者和方法:在巴格达Ibn Alhaitham教学眼科医院的门诊部进行的一项基于医院的随机临床试验,招募了60名急性单侧CSCR患者,随机(每隔一名患者)接受螺内酯25mg口服,每天两次,持续2个月(30名患者)或仅观察(30名病人)。随访包括所有患者在入组后一个月和两个月通过眼部相干断层扫描(OCT)进行视力测量、黄斑中心厚度和视网膜下液高度检查。结果:治疗组21眼(70%)和对照组6眼(20%)在两个月时观察到视网膜下液完全吸收。两组的视力和平均黄斑厚度在一个月和两个月时均有显著改善,在两个月的随访终点,治疗组的平均变化大于对照组。结论:与观察结果相比,口服螺内酯对急性中心性浆液性脉络膜视网膜病变患者的中心性黄斑厚度有更大的改善,视网膜下液的溶解速度更快。
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引用次数: 1
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