Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.155076.1372
Ahmed M. Elwakeel, A. E. El Midany, I. N. El-Sokkary, M. Mahmoud, Bahaa A. Elkhonezy, Haytham M. Abdelmoaty, Mohammed Wael Badawi, T. Hikal, M. Ahmed, A. Khaled, Mohammed E. ElSaid, Ibrahim K. Gamil, Mahmoud khadrawy, Mahmoud M. Elwakeel, Eman Mahmoud, Ahmed H. Lamloom
Background : Tricuspid valve disease is most commonly functional, however, organic affection still accounts for one fourth of cases. Rheumatic fever which is endemic in Egypt is a main cause of organic affection. Current practice largely relies on tricuspid valve repair; however, it has been difficult to determine optimal procedure. Objectives : Herein, we study the outcome of replacement versus repair in such patients. Patients and methods : A prospective study was conducted on 300 consecutive patients with rheumatic heart disease showing severe tricuspid valve affection underwent tricuspid valve surgery, between 2014 and 2018. The patients were divided into two groups; TVR group (n=150) which included patients who underwent tricuspid valve replacement and TVr group (n=150) which included patients who underwent tricuspid valve repair. Diagnosis and follow up were done by echocardiography. Peri-operative variables, clinical outcome, morbidity, mortality, and follow up data were recorded. Results: Mean follow-up was 4±1.32 years. In-hospital mortality was 6 patients (4%) in TVR group and 3 patients (2%) in TVr group (P value ≥ 0.05). Postoperative low cardiac output syndrome and stroke were significantly higher in the repair group. Postoperative RV dysfunction, renal impairment, renal failure and chest re-exploration were significantly higher in the replacement group. Severe tricuspid regurgitation was reported in 19 patients (12.6%) of the repair group on follow up. Conclusion : Tricuspid valve repair is preferable to replacement to avoid the drawbacks of prosthesis. However, tricuspid valve replacement is feasible with comparable survival outcome and the progressive nature of the rheumatic disease may recommend replacement.
{"title":"Rheumatic tricuspid valve disease: Repair versus Replacement","authors":"Ahmed M. Elwakeel, A. E. El Midany, I. N. El-Sokkary, M. Mahmoud, Bahaa A. Elkhonezy, Haytham M. Abdelmoaty, Mohammed Wael Badawi, T. Hikal, M. Ahmed, A. Khaled, Mohammed E. ElSaid, Ibrahim K. Gamil, Mahmoud khadrawy, Mahmoud M. Elwakeel, Eman Mahmoud, Ahmed H. Lamloom","doi":"10.21608/svuijm.2022.155076.1372","DOIUrl":"https://doi.org/10.21608/svuijm.2022.155076.1372","url":null,"abstract":"Background : Tricuspid valve disease is most commonly functional, however, organic affection still accounts for one fourth of cases. Rheumatic fever which is endemic in Egypt is a main cause of organic affection. Current practice largely relies on tricuspid valve repair; however, it has been difficult to determine optimal procedure. Objectives : Herein, we study the outcome of replacement versus repair in such patients. Patients and methods : A prospective study was conducted on 300 consecutive patients with rheumatic heart disease showing severe tricuspid valve affection underwent tricuspid valve surgery, between 2014 and 2018. The patients were divided into two groups; TVR group (n=150) which included patients who underwent tricuspid valve replacement and TVr group (n=150) which included patients who underwent tricuspid valve repair. Diagnosis and follow up were done by echocardiography. Peri-operative variables, clinical outcome, morbidity, mortality, and follow up data were recorded. Results: Mean follow-up was 4±1.32 years. In-hospital mortality was 6 patients (4%) in TVR group and 3 patients (2%) in TVr group (P value ≥ 0.05). Postoperative low cardiac output syndrome and stroke were significantly higher in the repair group. Postoperative RV dysfunction, renal impairment, renal failure and chest re-exploration were significantly higher in the replacement group. Severe tricuspid regurgitation was reported in 19 patients (12.6%) of the repair group on follow up. Conclusion : Tricuspid valve repair is preferable to replacement to avoid the drawbacks of prosthesis. However, tricuspid valve replacement is feasible with comparable survival outcome and the progressive nature of the rheumatic disease may recommend replacement.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88021864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.135321.1302
N. Hasan, M. Alam-Eldeen, Mohamed Abdelghany Elsherif, Mohammed Hazem
Background: Recently, multiparametric magnetic resonance imaging has been extensively used for early detection and localization of clinically significant prostate cancer. Magnetic resonance spectroscopy provides chemical information about metabolites in normal and abnormal tissues. It isn ’ t widely used in routine imaging of prostatic lesions. Objectives: to evaluate the diagnostic benefit from adding MRS to combined T2WI and DWI (bi-parametric MRI) in prostatic lesions diagnosis. Patients and Methods : This prospective study included MRI prostate of 128 adult male obtained by using 1.5 Tesla machine. They were presented by clinically suspected prostatic lesions and elevated PSA level (> 4 ng/dl). MRI protocol included T1WI, T2WI, DWI and MRS. Diagnostic accuracy of bi-parametric MRI was compared with that of MRS alone and that after adding MRS to T2WI and DWI using the histopathological diagnosis as the standard of reference. Results : 68 (53%) patients were histopathologically diagnosed with malignant prostatic lesions and 60 (47%) patients with benign lesions. Combined MRS with bi-parametric MRI had the highest diagnostic accuracy of 96.8% with sensitivity, specificity, PPV, and NPV of 100%, 93.3%, 94.4%, and 100% respectively compared with those of bi-parametric MRI; 71.9 % accuracy, 76.5% sensitivity, 66.7 % specificity, 72.2% PPV and 71.4% NPV and MRS that had 90.6 % accuracy, 100% sensitivity, 80 % specificity, 85% PPV and 100% NPV. Conclusion: Adding MRS to T2WI and DWI is a promising diagnostic tool for better detection and characterization of different malignant and benign prostatic lesions compared to bi-parametric MRI.
{"title":"Added value of MR spectroscopy to combined T2-weighted and diffusion weighted MRI in prostatic lesions characterization","authors":"N. Hasan, M. Alam-Eldeen, Mohamed Abdelghany Elsherif, Mohammed Hazem","doi":"10.21608/svuijm.2022.135321.1302","DOIUrl":"https://doi.org/10.21608/svuijm.2022.135321.1302","url":null,"abstract":"Background: Recently, multiparametric magnetic resonance imaging has been extensively used for early detection and localization of clinically significant prostate cancer. Magnetic resonance spectroscopy provides chemical information about metabolites in normal and abnormal tissues. It isn ’ t widely used in routine imaging of prostatic lesions. Objectives: to evaluate the diagnostic benefit from adding MRS to combined T2WI and DWI (bi-parametric MRI) in prostatic lesions diagnosis. Patients and Methods : This prospective study included MRI prostate of 128 adult male obtained by using 1.5 Tesla machine. They were presented by clinically suspected prostatic lesions and elevated PSA level (> 4 ng/dl). MRI protocol included T1WI, T2WI, DWI and MRS. Diagnostic accuracy of bi-parametric MRI was compared with that of MRS alone and that after adding MRS to T2WI and DWI using the histopathological diagnosis as the standard of reference. Results : 68 (53%) patients were histopathologically diagnosed with malignant prostatic lesions and 60 (47%) patients with benign lesions. Combined MRS with bi-parametric MRI had the highest diagnostic accuracy of 96.8% with sensitivity, specificity, PPV, and NPV of 100%, 93.3%, 94.4%, and 100% respectively compared with those of bi-parametric MRI; 71.9 % accuracy, 76.5% sensitivity, 66.7 % specificity, 72.2% PPV and 71.4% NPV and MRS that had 90.6 % accuracy, 100% sensitivity, 80 % specificity, 85% PPV and 100% NPV. Conclusion: Adding MRS to T2WI and DWI is a promising diagnostic tool for better detection and characterization of different malignant and benign prostatic lesions compared to bi-parametric MRI.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86209693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.124420.1286
A. Mehta, Rajesh K. Gupta, M. Ajmariya
: Background : As per World Health Organization (WHO), sepsis is a leading cause of hospitalization and death in children in developing countries.The rapidly changing bacteriologic profile of childhood sepsis warrants the need for an ongoing review of the etiopathogenesis and drug susceptibility pattern of causative agents. Objectives: To find out the etiological profile and antibiotic sensitivity pattern of the pathogens causing pediatric sepsis in a tertiary care teaching hospital of Central India. Materials and Methods : This is a cross-sectional study. 194 clinical samples were collected from inpatients ranging in age from >1 month to 15 years. Isolation and identification of pathogens were done using Standard microbiological techniques. Antimicrobial susceptibility testing was performed by the standard Kirby Bauer disc diffusion method and interpreted as per CLSI guidelines. Results :Out of the total 87 blood culture isolates majority were Gram Positive cocci (70%); with Staphylococcus aureus (53%) being the most predominant organism. The GPC isolates showed high susceptibility towards Vancomycin, Linezolid, Piperacillin tazobactam, and Tetracyclines. Methicillin resistance was reported in 38% of Staphylococcus aureus isolates. 40% of Enterococcus isolates exhibited High-level Aminoglycoside resistance.Enterobacteriaceae isolates exhibited high susceptibility towards Carbapenems, Colistin, Piperacillin tazobactum& Ceftazidime clavulanate. 40% of E.coli isolates & 50% of K.pneumoniae isolates were found to be Extended- spectrum β lactamase ( ESBL) producers. Non-fermenters exhibited high sensitivity towards Meropenem, Colistin, Piperacillin tazobactam, Amikacin. Conclusions : The present study has provided much-needed information on the local antimicrobial profile of the prevailing pathogens causing pediatric sepsis which will be helpful in guiding their management.
{"title":"Microbiological profile of Pediatric sepsis in a tertiary care teaching hospital of Central India","authors":"A. Mehta, Rajesh K. Gupta, M. Ajmariya","doi":"10.21608/svuijm.2022.124420.1286","DOIUrl":"https://doi.org/10.21608/svuijm.2022.124420.1286","url":null,"abstract":": Background : As per World Health Organization (WHO), sepsis is a leading cause of hospitalization and death in children in developing countries.The rapidly changing bacteriologic profile of childhood sepsis warrants the need for an ongoing review of the etiopathogenesis and drug susceptibility pattern of causative agents. Objectives: To find out the etiological profile and antibiotic sensitivity pattern of the pathogens causing pediatric sepsis in a tertiary care teaching hospital of Central India. Materials and Methods : This is a cross-sectional study. 194 clinical samples were collected from inpatients ranging in age from >1 month to 15 years. Isolation and identification of pathogens were done using Standard microbiological techniques. Antimicrobial susceptibility testing was performed by the standard Kirby Bauer disc diffusion method and interpreted as per CLSI guidelines. Results :Out of the total 87 blood culture isolates majority were Gram Positive cocci (70%); with Staphylococcus aureus (53%) being the most predominant organism. The GPC isolates showed high susceptibility towards Vancomycin, Linezolid, Piperacillin tazobactam, and Tetracyclines. Methicillin resistance was reported in 38% of Staphylococcus aureus isolates. 40% of Enterococcus isolates exhibited High-level Aminoglycoside resistance.Enterobacteriaceae isolates exhibited high susceptibility towards Carbapenems, Colistin, Piperacillin tazobactum& Ceftazidime clavulanate. 40% of E.coli isolates & 50% of K.pneumoniae isolates were found to be Extended- spectrum β lactamase ( ESBL) producers. Non-fermenters exhibited high sensitivity towards Meropenem, Colistin, Piperacillin tazobactam, Amikacin. Conclusions : The present study has provided much-needed information on the local antimicrobial profile of the prevailing pathogens causing pediatric sepsis which will be helpful in guiding their management.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80807284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.139532.1315
A. Altaher, Esraa T A Mustafa, Lotfy Hamed Abodahab, H. Mohamed
Background: One of the most significant modifiable risk factors for coronary artery disease (CAD) is dyslipidemia. Acute coronary syndromes (ACS) were shown to be a key contributing factor to patients being admitted to the Coronary Care Unit (CCU) at Sohag University Hospital. Objectives: To analyze lipid profile in patients with ACS who presents at Sohag university hospital, and its clinical and complications pattern. Patiets and methods: This study involved 100 patients above 18 years old diagnosed with ACS. Patients were classified into 3 groups; ST-elevation MI (STEMI), non-ST-elevation MI (NSTEMI) and unstable angina (UA) group. All participants were subjected to history taking, clinical assessment and measuring complete lipid profile values. Results: STEMI group has higher significant total cholesterol (TC), low-density lipoprotein cholesterol LDL-C (P < 0.001), Triglycerides (TG) (P =0.022), TC/HDL (P =0.027 ) and TG/HDL levels (P = 0.001) and lower significant high-density lipoprotein cholesterol (HDL-C) (p=0.006) than other groups. There was a significant correlation between age groups and TC (P<0.001), LDL-c (P=0.009), very low-density lipoprotein cholesterol (VLDL-c) (P=0.016), HDL (P=0.001), Triglycerides (P=0.008), TC/HDL (P<0.001) and TG/HDL (P=0.040). Furthermore, there was no significant correlation between gender and TC, LDL-c, VLDL, HDL, TG, TC/HDL and TG/HDL (P>0.05). Conclusion: Patients with ACS have a significant prevalence of dyslipidemia as a risk factor. These individuals are more likely to have low HDL than high LDL values; nevertheless, they are more likely to have high TG values than low HDL values.
{"title":"The Pattern of Dyslipidemia among Patients with Acute Coronary Syndrome at Sohag University Hospital","authors":"A. Altaher, Esraa T A Mustafa, Lotfy Hamed Abodahab, H. Mohamed","doi":"10.21608/svuijm.2022.139532.1315","DOIUrl":"https://doi.org/10.21608/svuijm.2022.139532.1315","url":null,"abstract":"Background: One of the most significant modifiable risk factors for coronary artery disease (CAD) is dyslipidemia. Acute coronary syndromes (ACS) were shown to be a key contributing factor to patients being admitted to the Coronary Care Unit (CCU) at Sohag University Hospital. Objectives: To analyze lipid profile in patients with ACS who presents at Sohag university hospital, and its clinical and complications pattern. Patiets and methods: This study involved 100 patients above 18 years old diagnosed with ACS. Patients were classified into 3 groups; ST-elevation MI (STEMI), non-ST-elevation MI (NSTEMI) and unstable angina (UA) group. All participants were subjected to history taking, clinical assessment and measuring complete lipid profile values. Results: STEMI group has higher significant total cholesterol (TC), low-density lipoprotein cholesterol LDL-C (P < 0.001), Triglycerides (TG) (P =0.022), TC/HDL (P =0.027 ) and TG/HDL levels (P = 0.001) and lower significant high-density lipoprotein cholesterol (HDL-C) (p=0.006) than other groups. There was a significant correlation between age groups and TC (P<0.001), LDL-c (P=0.009), very low-density lipoprotein cholesterol (VLDL-c) (P=0.016), HDL (P=0.001), Triglycerides (P=0.008), TC/HDL (P<0.001) and TG/HDL (P=0.040). Furthermore, there was no significant correlation between gender and TC, LDL-c, VLDL, HDL, TG, TC/HDL and TG/HDL (P>0.05). Conclusion: Patients with ACS have a significant prevalence of dyslipidemia as a risk factor. These individuals are more likely to have low HDL than high LDL values; nevertheless, they are more likely to have high TG values than low HDL values.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76885052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.125376.1291
Mona Gad Mohammed, M. Iwes, Mahmoud Almolakab B Alrashedy
Background: The fluid that envelops a growing fetus in the amniotic sac is called amniotic fluid (AF), many maternal and fetal components share in composition of amniotic fluid, in the last three months of pregnancy, AF turbidity increases and was associated with the appearance of vernix caseosa and meconium. Objectives: To estimate the nature of the echogenic amniotic fluid and to overcome unnecessary intervention due to turbid amniotic fluid. Patients and Methods : A total of 116 Pregnant women (near or full term) who delivered at emergency unit of Obstet. and Gynecol, South Valley University with reliable dates of LMP and delivered after normal vaginal delivery or by CS. full history, clinical examination, US findings (echogenic amniotic fluid), gestational age, and investigations were recorded. also neonatal weight, APGAR Score and nature of amniotic fluid after delivery were recorded. Results: The current study showed that regarding nature of amniotic fluid after delivery, (0.9%) had bloody, (4.3%) had meconium and (94.8%) had vernix caseosa.According to US, AFI was Average in (90.5%), Decreased in (7.8%) and increased in (1.7%).Mean of gestational age at time of termination was (38.29 ± 1.37).Our results showed that according to mode of delivery (55.2%) were NVD and (44.8%) were CS. The median of APGAR score of neonate was (8.00). Conclusions: echogenic amniotic fluid had clinical significance and 94.8% of pregnant women (near or full term) with turbid amniotic fluid showed presence of vernix caseosa
{"title":"Clinical significance of turbid amniotic fluid on peripartum outcome","authors":"Mona Gad Mohammed, M. Iwes, Mahmoud Almolakab B Alrashedy","doi":"10.21608/svuijm.2022.125376.1291","DOIUrl":"https://doi.org/10.21608/svuijm.2022.125376.1291","url":null,"abstract":"Background: The fluid that envelops a growing fetus in the amniotic sac is called amniotic fluid (AF), many maternal and fetal components share in composition of amniotic fluid, in the last three months of pregnancy, AF turbidity increases and was associated with the appearance of vernix caseosa and meconium. Objectives: To estimate the nature of the echogenic amniotic fluid and to overcome unnecessary intervention due to turbid amniotic fluid. Patients and Methods : A total of 116 Pregnant women (near or full term) who delivered at emergency unit of Obstet. and Gynecol, South Valley University with reliable dates of LMP and delivered after normal vaginal delivery or by CS. full history, clinical examination, US findings (echogenic amniotic fluid), gestational age, and investigations were recorded. also neonatal weight, APGAR Score and nature of amniotic fluid after delivery were recorded. Results: The current study showed that regarding nature of amniotic fluid after delivery, (0.9%) had bloody, (4.3%) had meconium and (94.8%) had vernix caseosa.According to US, AFI was Average in (90.5%), Decreased in (7.8%) and increased in (1.7%).Mean of gestational age at time of termination was (38.29 ± 1.37).Our results showed that according to mode of delivery (55.2%) were NVD and (44.8%) were CS. The median of APGAR score of neonate was (8.00). Conclusions: echogenic amniotic fluid had clinical significance and 94.8% of pregnant women (near or full term) with turbid amniotic fluid showed presence of vernix caseosa","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83816508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.124787.1288
A. Abdelraheem, Manar Mahran Sadek, N. Abdelrahman, Aida A. Abdelmaksoud
Background: Mucoperichondrial flap elevation is the first step in septoplasty operation. MESNA was used in flap elevation to decrease the amount of bleeding, get better surgical field, decrease the operation time and lessen mucosal damage. Objectives: To evaluate the effect of submucosal injection of sodium 2-mercaptoethanesulfonate (MESNA) on the operation time, intra-operative blood loss, integrity of the flap in septoplasty and post operative pain. Patients and methods: It is a case control study that was conducted on 60 patients their ages ranged from 18 years to 43 years, all were underwent septoplasty operation by the same surgeon at Otorhinolaryngology Department, Qena University hospitals, Egypt. Results: Results revealed that the mean time of flap elevation was 6.7 ± 1.8 SD minutes in group A, but was 10.9 ± 2.2 SD minutes in group B which was highly statistical significant with p-value < 0.001.As regard the mean of Intra-operative blood loss it was82 ±15.9 SD ml. in group A, but was 109.7 ± 21.8 SD ml. in group B which was highly statistical significant with p-value < 0.001. Conclusion : Submucosal injection of sodium 2- mercaptoethanesulfonate (MESNA) being more advantageous method that make mucoperichondrial flap elevation is convenient and effective and preserving mucosal integrity in surgical treatment of deviated nasal septum .
{"title":"Effect of Submucosal Injection of Sodium 2- Mercaptoethanesulfonate in Surgical Treatment of Deviated Nasal Septum","authors":"A. Abdelraheem, Manar Mahran Sadek, N. Abdelrahman, Aida A. Abdelmaksoud","doi":"10.21608/svuijm.2022.124787.1288","DOIUrl":"https://doi.org/10.21608/svuijm.2022.124787.1288","url":null,"abstract":"Background: Mucoperichondrial flap elevation is the first step in septoplasty operation. MESNA was used in flap elevation to decrease the amount of bleeding, get better surgical field, decrease the operation time and lessen mucosal damage. Objectives: To evaluate the effect of submucosal injection of sodium 2-mercaptoethanesulfonate (MESNA) on the operation time, intra-operative blood loss, integrity of the flap in septoplasty and post operative pain. Patients and methods: It is a case control study that was conducted on 60 patients their ages ranged from 18 years to 43 years, all were underwent septoplasty operation by the same surgeon at Otorhinolaryngology Department, Qena University hospitals, Egypt. Results: Results revealed that the mean time of flap elevation was 6.7 ± 1.8 SD minutes in group A, but was 10.9 ± 2.2 SD minutes in group B which was highly statistical significant with p-value < 0.001.As regard the mean of Intra-operative blood loss it was82 ±15.9 SD ml. in group A, but was 109.7 ± 21.8 SD ml. in group B which was highly statistical significant with p-value < 0.001. Conclusion : Submucosal injection of sodium 2- mercaptoethanesulfonate (MESNA) being more advantageous method that make mucoperichondrial flap elevation is convenient and effective and preserving mucosal integrity in surgical treatment of deviated nasal septum .","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86962522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.136476.1307
M. Ajmariya, Deepak Sinha, P. Agrawal, A. Mehta, Deepika Singh
Background: Epilepsy is a widespread neurological illness with significant medical, social, and psychological implications. Valproate, Oxcarbazepine, and Levetiracetam are the most regularly used long-term antiepileptic drugs (AEDs) in children today. Objectives: To assess the effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function of children with epilepsy. Patients and methods: This prospective observational study was carried out from May 2019 to December 2020 involving children of age group 1-12 years. Any child with newly diagnosed epilepsy being started on monotherapy with Levetiracetam/Valproate/Oxcarbazepine was included in the study. Their baseline thyroid profile and thyroid function at 6 th month and 12 th month of starting the antiepileptics were evaluated through Biochemical parameters -T3, T4 & TSH. These values were analyzed and compared by applying paired t-test to determine the effect of antiepileptic therapy on the thyroid function of the study subjects. Results: In the study, a total of 66 study participants were included of which 51 (77.3%) were males and 15 (22.7%) females. Among the study participants, generalized tonic-clonic seizures were seen in 36 (55%) study participants. As an antiepileptic treatment, Valproate was administered to 34 (51.5%), levetiracetam to 24 (36.4%), and oxcarbazepine to 8 (12.1%) of the study participants. Mean values of TSH, total T3, and total T4 scores at baseline were 1.7, 3.04, and 8.05 respectively; at 6 months were 3.17, 3.4, and 1.4 respectively, at 12 months were 4.9, 3.2, and 5.9. A significant increase in TSH and decrease in T4 values as compared to baseline levels was observed after antiepileptic therapy in the target group indicating a suppressive effect on thyroid function. Conclusion: This study has depicted a significant negative effect of anti-epileptic therapy on thyroid function in children.
{"title":"The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children","authors":"M. Ajmariya, Deepak Sinha, P. Agrawal, A. Mehta, Deepika Singh","doi":"10.21608/svuijm.2022.136476.1307","DOIUrl":"https://doi.org/10.21608/svuijm.2022.136476.1307","url":null,"abstract":"Background: Epilepsy is a widespread neurological illness with significant medical, social, and psychological implications. Valproate, Oxcarbazepine, and Levetiracetam are the most regularly used long-term antiepileptic drugs (AEDs) in children today. Objectives: To assess the effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function of children with epilepsy. Patients and methods: This prospective observational study was carried out from May 2019 to December 2020 involving children of age group 1-12 years. Any child with newly diagnosed epilepsy being started on monotherapy with Levetiracetam/Valproate/Oxcarbazepine was included in the study. Their baseline thyroid profile and thyroid function at 6 th month and 12 th month of starting the antiepileptics were evaluated through Biochemical parameters -T3, T4 & TSH. These values were analyzed and compared by applying paired t-test to determine the effect of antiepileptic therapy on the thyroid function of the study subjects. Results: In the study, a total of 66 study participants were included of which 51 (77.3%) were males and 15 (22.7%) females. Among the study participants, generalized tonic-clonic seizures were seen in 36 (55%) study participants. As an antiepileptic treatment, Valproate was administered to 34 (51.5%), levetiracetam to 24 (36.4%), and oxcarbazepine to 8 (12.1%) of the study participants. Mean values of TSH, total T3, and total T4 scores at baseline were 1.7, 3.04, and 8.05 respectively; at 6 months were 3.17, 3.4, and 1.4 respectively, at 12 months were 4.9, 3.2, and 5.9. A significant increase in TSH and decrease in T4 values as compared to baseline levels was observed after antiepileptic therapy in the target group indicating a suppressive effect on thyroid function. Conclusion: This study has depicted a significant negative effect of anti-epileptic therapy on thyroid function in children.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76216041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.129549.1297
G. Saxena, K. Sadawarte, Prafulla Songara, A. Mehta
Background : Dermatophytosis is a disease of hair, nails, and stratum corneum of the skin caused by dermatophytes. The prevalence of dermatophytosis in a geographical area depends on a variety of factors such as climate, personal hygiene, and individual susceptibility. The clinical importance of isolating and identifying dermatophytes is to start appropriate treatment & to detect probable infection sources. Also, identification is important for prognostic consideration. Objectives: Our study aims to know the clinico-mycological profile in suspected cases of dermatophytosis. Patients and Methods : A total of 110 suspected cases of dermatophytoses that were diagnosed clinically by a dermatologist were included in this study. Specimen of skin scrapings, hairs & nail clippings wherever appropriate were collected from these patients. Specimens collected were subjected to standard mycological procedures. Results : In our study, the most common age group affected was 21-30 years (31.82%). The majority of the cases were from the lower middle class (38%). The commonest clinical type was Tinea corporis (48%). In 72.73% of cases, we were able to detect fungi either by direct microscopy and/or culture. Out of 62 culture isolates, T.rubrum was found to be the commonest (59.7%), followed by T.mentagrophytes (24.2%), E.floccosum (6.5%), T.tonsurans (3.2%), M. gypseum (3.2%) and one isolate each of M. audouinii and M. canis . Conclusion : With proper techniques, various species of dermatophytes can be identified. But conventional methods are time-consuming and a week to a month is required for identification to species level. So the development of rapid molecular techniques is the need of the hour.
{"title":"Clinico-Mycological Profile of Dermatophytoses at a Tertiary Care Teaching Hospital of Central India","authors":"G. Saxena, K. Sadawarte, Prafulla Songara, A. Mehta","doi":"10.21608/svuijm.2022.129549.1297","DOIUrl":"https://doi.org/10.21608/svuijm.2022.129549.1297","url":null,"abstract":"Background : Dermatophytosis is a disease of hair, nails, and stratum corneum of the skin caused by dermatophytes. The prevalence of dermatophytosis in a geographical area depends on a variety of factors such as climate, personal hygiene, and individual susceptibility. The clinical importance of isolating and identifying dermatophytes is to start appropriate treatment & to detect probable infection sources. Also, identification is important for prognostic consideration. Objectives: Our study aims to know the clinico-mycological profile in suspected cases of dermatophytosis. Patients and Methods : A total of 110 suspected cases of dermatophytoses that were diagnosed clinically by a dermatologist were included in this study. Specimen of skin scrapings, hairs & nail clippings wherever appropriate were collected from these patients. Specimens collected were subjected to standard mycological procedures. Results : In our study, the most common age group affected was 21-30 years (31.82%). The majority of the cases were from the lower middle class (38%). The commonest clinical type was Tinea corporis (48%). In 72.73% of cases, we were able to detect fungi either by direct microscopy and/or culture. Out of 62 culture isolates, T.rubrum was found to be the commonest (59.7%), followed by T.mentagrophytes (24.2%), E.floccosum (6.5%), T.tonsurans (3.2%), M. gypseum (3.2%) and one isolate each of M. audouinii and M. canis . Conclusion : With proper techniques, various species of dermatophytes can be identified. But conventional methods are time-consuming and a week to a month is required for identification to species level. So the development of rapid molecular techniques is the need of the hour.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75507073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.127300.1294
A. Magdy, A. Mahmoud, A. Youssef
Background: Thyroid nodules are common disorder of the thyroid gland. Early and precise diagnosis of malignant thyroid nodules is fundamental for effective treatment. Objectives: The purpose of this study is comparative evaluation of the diagnostic performance of TI-RADS, elasticity score, strain ratio and quantitative diffusion-weighted MRI in characterization of malignant and benign thyroid nodules. Patients and methods: Our study is prospective. 59 patients with 59 thyroid nodules were enrolled in this study. Conventional ultrasound with TI-RADS categorization, ultrasound strain elastography (elasticity score and strain ratio) as well as diffusion-weighted MR imaging and ADC value were evaluated for all cases. Histopathology results were the standard reference. Results: TI-RADS score had (80 %) sensitivity, (89.8 %) specificity and (84.9 %) accuracy. Elasticity score using 4-points Asteria's criteria with cutoff value =3 had (70 %) sensitivity, (91.8 %) specificity and (80.9 %) accuracy. When a cutoff value of 1.65 was used for strain ratio; (90 %) sensitivity, (71.4 %) specificity and (91.8 %) diagnostic accuracy noted. When a cutoff value of 1.45 x10-3 was used for ADC value; (80 %) sensitivity, (95.9 %) specificity and overall accuracy (98%) noticed. Multiparametric analysis enhanced the overall accuracy of TI-RADS scoring with the best diagnostic performance was achieved in our study by combining diffusion ADC value to the TI-RADS scoring with sensitivity 100%, specificity 95.9% and accuracy 98%. Conclusions: Strain ratio and diffusion ADC value had higher diagnostic performance than US TIRADS scoring in characterizing thyroid nodules. The best diagnostic performance in our study was achieved by combining diffusion ADC value to the TI-RADS scoring with overall accuracy of about 98%.
{"title":"Comparative Study of TI-RADS, Elasticity Score, Strain Ratio and Quantitative Diffusion MR Weighted Imaging in Characterization of Thyroid Nodules; Which Has the Best Diagnostic performance?","authors":"A. Magdy, A. Mahmoud, A. Youssef","doi":"10.21608/svuijm.2022.127300.1294","DOIUrl":"https://doi.org/10.21608/svuijm.2022.127300.1294","url":null,"abstract":"Background: Thyroid nodules are common disorder of the thyroid gland. Early and precise diagnosis of malignant thyroid nodules is fundamental for effective treatment. Objectives: The purpose of this study is comparative evaluation of the diagnostic performance of TI-RADS, elasticity score, strain ratio and quantitative diffusion-weighted MRI in characterization of malignant and benign thyroid nodules. Patients and methods: Our study is prospective. 59 patients with 59 thyroid nodules were enrolled in this study. Conventional ultrasound with TI-RADS categorization, ultrasound strain elastography (elasticity score and strain ratio) as well as diffusion-weighted MR imaging and ADC value were evaluated for all cases. Histopathology results were the standard reference. Results: TI-RADS score had (80 %) sensitivity, (89.8 %) specificity and (84.9 %) accuracy. Elasticity score using 4-points Asteria's criteria with cutoff value =3 had (70 %) sensitivity, (91.8 %) specificity and (80.9 %) accuracy. When a cutoff value of 1.65 was used for strain ratio; (90 %) sensitivity, (71.4 %) specificity and (91.8 %) diagnostic accuracy noted. When a cutoff value of 1.45 x10-3 was used for ADC value; (80 %) sensitivity, (95.9 %) specificity and overall accuracy (98%) noticed. Multiparametric analysis enhanced the overall accuracy of TI-RADS scoring with the best diagnostic performance was achieved in our study by combining diffusion ADC value to the TI-RADS scoring with sensitivity 100%, specificity 95.9% and accuracy 98%. Conclusions: Strain ratio and diffusion ADC value had higher diagnostic performance than US TIRADS scoring in characterizing thyroid nodules. The best diagnostic performance in our study was achieved by combining diffusion ADC value to the TI-RADS scoring with overall accuracy of about 98%.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81387109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.136000.1305
A. Ali, Altayeb Abd-alal Mostafa, Mostafa Hussein, Mostafa Mohammad Khodry
Background : Monochorionic diamniotic (MCDA) twins have a substantially higher risk for perinatal morbidity and mortality due to the presence of placental vascular anastomoses between the twins. Objectives: The primary purpose of this research was to confirm the accuracy of first trimester ultrasonography in predicting selective intrauterine growth restriction (SIGR) and twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies using the triad of nuchal translucency (NT), cord insertion and inter-twin discordance in foetal size. Patients and methods: This was a prospective cohort study that included 31 pregnant women who were carrying monochorionic twins during the first trimester. The research was carried out at a foetal medicine unite, Obstetrics and Gynecology Department, South Valley University Hospital. The duration of the study ranged from 18 to 24 months. Results : the mean difference in NT can determine TTTS with fair sensitivity (73.2%) and high specificity (100%) in twins (p<0.001). Likewise, mean difference in CRL can determine TTTS with fair sensitivity (73.1%) and high specificity (100%) in twins (p<0.001).The mean difference in NT can determine sIUGR with high sensitivity (100%) and fair specificity (73.2%) in twins (p<0.001). Likewise, mean difference in CRL can determine sIUGR with high sensitivity (100%) and fair specificity (73.1%) in twins (p<0.001). Conclusion : we have demonstrated that NT and CRL were significantly higher in TTTS group, and NT and CRL were respectively identified as the predictive markers for sIUGR and TTTS.
{"title":"Predictive values of first trimester ultrasound screening for twin-to-twin transfusion syndrome and selective intrauterine growth restriction in monochorionic twin pregnancies","authors":"A. Ali, Altayeb Abd-alal Mostafa, Mostafa Hussein, Mostafa Mohammad Khodry","doi":"10.21608/svuijm.2022.136000.1305","DOIUrl":"https://doi.org/10.21608/svuijm.2022.136000.1305","url":null,"abstract":"Background : Monochorionic diamniotic (MCDA) twins have a substantially higher risk for perinatal morbidity and mortality due to the presence of placental vascular anastomoses between the twins. Objectives: The primary purpose of this research was to confirm the accuracy of first trimester ultrasonography in predicting selective intrauterine growth restriction (SIGR) and twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies using the triad of nuchal translucency (NT), cord insertion and inter-twin discordance in foetal size. Patients and methods: This was a prospective cohort study that included 31 pregnant women who were carrying monochorionic twins during the first trimester. The research was carried out at a foetal medicine unite, Obstetrics and Gynecology Department, South Valley University Hospital. The duration of the study ranged from 18 to 24 months. Results : the mean difference in NT can determine TTTS with fair sensitivity (73.2%) and high specificity (100%) in twins (p<0.001). Likewise, mean difference in CRL can determine TTTS with fair sensitivity (73.1%) and high specificity (100%) in twins (p<0.001).The mean difference in NT can determine sIUGR with high sensitivity (100%) and fair specificity (73.2%) in twins (p<0.001). Likewise, mean difference in CRL can determine sIUGR with high sensitivity (100%) and fair specificity (73.1%) in twins (p<0.001). Conclusion : we have demonstrated that NT and CRL were significantly higher in TTTS group, and NT and CRL were respectively identified as the predictive markers for sIUGR and TTTS.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81718354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：