Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.149784.1340
H. Mahmoud, M. Alemam, Z. Ahmed, H. Osman
Background: Formerly, treating hepatitis C virus (HCV) infection in individuals suffering from chronic renal disease was challenging due to the toxicity of interferon (IFN). Ombitasvir, paritaprevir, and ritonavir are examples of safe and effective pan-genotypic direct-acting antiviral (DAA) regimens that make it easier for individuals with chronic kidney disease to treat their hepatitis C virus (HCV). Objectives: To assess the effectiveness and safety of Omibtasvir, paritaprevir, and ritonavir when used in conjunction with Ribavirin for the treatment of hepatitis C patients who have end-stage kidney disease. Patients and methods: 100 individuals with severe renal illnesses and chronic hepatitis C virus were included in this cross-sectional investigation. The estimated glomerular filtration rate (eGFR) was calculated after each patient underwent a thorough medical history, physical examination, and laboratory testing that included a complete blood count, ALT, AST, and kidney function tests. Fibroscan and pelvic abdominal ultrasonography were carried out. The patients received ribavirin together with paritaprevir/ritonavir and ombitasvir (75/50/12.5mg) twice day for 12 weeks. Results : Sustained virologic response (SVR) was 83 % (83 patients) overall patients. Patients were divided into two groups according to sustained virologic response. Child Pugh-turcotte (CPT) score was higher in non responders when compared with responders (5.7 ± 0.4 vs 5.4 ± 0.4; P-value = 0.002). Regarding to Safety and tolerability of DAAs, no severe adverse events were reported during the present study with no discontinuing treatment due to adverse events. The most frequent adverse events were anemia, headache, pruritus, anorexia and malaise. Conclusion : OBV/PTV/RTV plus Ribavirin can be used in treatment of chronic HCV patients with ESRD with high virologic response and highly safety profile.
背景:以前，由于干扰素(IFN)的毒性，治疗慢性肾脏疾病患者的丙型肝炎病毒(HCV)感染具有挑战性。Ombitasvir, paritaprevir和ritonavir是安全有效的泛基因型直接作用抗病毒(DAA)方案的例子，使慢性肾脏疾病患者更容易治疗丙型肝炎病毒(HCV)。目的:评估Omibtasvir、paritaprevir和ritonavir联合利巴韦林治疗终末期肾病的丙型肝炎患者的有效性和安全性。患者和方法:本横断面调查纳入了100例患有严重肾脏疾病和慢性丙型肝炎病毒的患者。估计的肾小球滤过率(eGFR)是在每位患者经过全面的病史、体格检查和实验室检查(包括全血细胞计数、ALT、AST和肾功能检查)后计算出来的。进行纤维扫描和盆腔腹部超声检查。利巴韦林联合paritaprevir/ritonavir和ombitasvir (75/50/12.5mg)治疗12周，每日2次。结果:83例患者的持续病毒学应答(SVR)为83%。根据持续病毒学反应情况将患者分为两组。无应答者的儿童Pugh-turcotte (CPT)评分高于应答者(5.7±0.4 vs 5.4±0.4;p值= 0.002)。关于DAAs的安全性和耐受性，在本研究中没有报道严重的不良事件，也没有因不良事件而停止治疗。最常见的不良事件是贫血、头痛、瘙痒、厌食和不适。结论:OBV/PTV/RTV联合利巴韦林治疗慢性HCV合并ESRD患者具有高病毒学应答和高安全性。
{"title":"Safety and Efficacy of Ombitasvir, Paritaprevirand Ritonavir Combination with Ribavirin for Treatment of Chronic Hepatitis C Virus in Advanced Kidney Diseases Patients in Upper Egypt","authors":"H. Mahmoud, M. Alemam, Z. Ahmed, H. Osman","doi":"10.21608/svuijm.2022.149784.1340","DOIUrl":"https://doi.org/10.21608/svuijm.2022.149784.1340","url":null,"abstract":"Background: Formerly, treating hepatitis C virus (HCV) infection in individuals suffering from chronic renal disease was challenging due to the toxicity of interferon (IFN). Ombitasvir, paritaprevir, and ritonavir are examples of safe and effective pan-genotypic direct-acting antiviral (DAA) regimens that make it easier for individuals with chronic kidney disease to treat their hepatitis C virus (HCV). Objectives: To assess the effectiveness and safety of Omibtasvir, paritaprevir, and ritonavir when used in conjunction with Ribavirin for the treatment of hepatitis C patients who have end-stage kidney disease. Patients and methods: 100 individuals with severe renal illnesses and chronic hepatitis C virus were included in this cross-sectional investigation. The estimated glomerular filtration rate (eGFR) was calculated after each patient underwent a thorough medical history, physical examination, and laboratory testing that included a complete blood count, ALT, AST, and kidney function tests. Fibroscan and pelvic abdominal ultrasonography were carried out. The patients received ribavirin together with paritaprevir/ritonavir and ombitasvir (75/50/12.5mg) twice day for 12 weeks. Results : Sustained virologic response (SVR) was 83 % (83 patients) overall patients. Patients were divided into two groups according to sustained virologic response. Child Pugh-turcotte (CPT) score was higher in non responders when compared with responders (5.7 ± 0.4 vs 5.4 ± 0.4; P-value = 0.002). Regarding to Safety and tolerability of DAAs, no severe adverse events were reported during the present study with no discontinuing treatment due to adverse events. The most frequent adverse events were anemia, headache, pruritus, anorexia and malaise. Conclusion : OBV/PTV/RTV plus Ribavirin can be used in treatment of chronic HCV patients with ESRD with high virologic response and highly safety profile.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"os-48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87247286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2023.192946.1520
M. Chauhan, S. Gautam, Sunita Kumari, Anjali Gupta, S. Nanda
{"title":"To compare the Fetomaternal outcome of natural birth versus induced birth after previous one caesarean section: A prospective Observational study","authors":"M. Chauhan, S. Gautam, Sunita Kumari, Anjali Gupta, S. Nanda","doi":"10.21608/svuijm.2023.192946.1520","DOIUrl":"https://doi.org/10.21608/svuijm.2023.192946.1520","url":null,"abstract":"","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80982024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.175551.1451
Mohamed Khashaba, Adel F. Al-Kholy, S. Salman
Background: Immune balance is mandatory for proper postoperative (PO) courses and wound healing. Cesarean section is the commonest surgical procedure for females. The choice of anesthetic procedure may affect the mother and fetal outcomes. Objectives: Evaluation of the impact of general (GA) versus spinal anesthesia (SA) on parturient' cytokines' serum levels. Patients and methods: 73 and 59 parturients received GA and SA, respectively. Fetal APGAR scoring was determined at 1-min & 5-min PO. PO pain severity was evaluated using the numeric rating scale and the duration of analgesia was calculated. Blood samples (S1, S2, S3) were obtained for ELISA estimation of serum interleukins and tumor necrosis factor- α (TNF - α). The study outcome is the effect of the anesthetic procedure on serum cytokines levels. Results: Cytokines' levels were significantly higher in S2 and S3 than in S1 samples of all parturients with significantly higher levels in samples of GA patients. Percentages of change in serum cytokines' levels were higher with GA than with SA. Receiver operating characteristic (ROC) curve defined serum levels of TNF- α as the most cytokine affected by the anesthetic procedure. APGAR scores were significantly higher at 1-min and the duration of PO analgesia was significantly longer with SA. Conclusion: SA can lessen the surgery-induced release of inflammatory cytokines, while GA augments this effect. Moreover, neonatal and maternal outcomes were superior with SA than with GA.
{"title":"Spinal Anesthesia and Minimal Tissue Trauma Improve the Outcome of Elective Cesarean Section","authors":"Mohamed Khashaba, Adel F. Al-Kholy, S. Salman","doi":"10.21608/svuijm.2022.175551.1451","DOIUrl":"https://doi.org/10.21608/svuijm.2022.175551.1451","url":null,"abstract":"Background: Immune balance is mandatory for proper postoperative (PO) courses and wound healing. Cesarean section is the commonest surgical procedure for females. The choice of anesthetic procedure may affect the mother and fetal outcomes. Objectives: Evaluation of the impact of general (GA) versus spinal anesthesia (SA) on parturient' cytokines' serum levels. Patients and methods: 73 and 59 parturients received GA and SA, respectively. Fetal APGAR scoring was determined at 1-min & 5-min PO. PO pain severity was evaluated using the numeric rating scale and the duration of analgesia was calculated. Blood samples (S1, S2, S3) were obtained for ELISA estimation of serum interleukins and tumor necrosis factor- α (TNF - α). The study outcome is the effect of the anesthetic procedure on serum cytokines levels. Results: Cytokines' levels were significantly higher in S2 and S3 than in S1 samples of all parturients with significantly higher levels in samples of GA patients. Percentages of change in serum cytokines' levels were higher with GA than with SA. Receiver operating characteristic (ROC) curve defined serum levels of TNF- α as the most cytokine affected by the anesthetic procedure. APGAR scores were significantly higher at 1-min and the duration of PO analgesia was significantly longer with SA. Conclusion: SA can lessen the surgery-induced release of inflammatory cytokines, while GA augments this effect. Moreover, neonatal and maternal outcomes were superior with SA than with GA.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86880316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2023.185178.1485
A. Hagras, M. Hagras, Amr Sharafeldeen
{"title":"Endometrioma Cystic Fluid Aspiration and Retained Ethanol Sclerotherapy might improve the systemic Immune Milieu","authors":"A. Hagras, M. Hagras, Amr Sharafeldeen","doi":"10.21608/svuijm.2023.185178.1485","DOIUrl":"https://doi.org/10.21608/svuijm.2023.185178.1485","url":null,"abstract":"","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83372899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.167431.1430
Ahmad Mokhtar Abodahab, Ebtsam Ahmed Mohammed Abdelbary
: Background: Falling from height is a common condition that can occur in different age groups. Many types of injuries can occur due to it, such as skull fractures. Skull penetrating foreign bodies (other than fire arm injuries and explosives) are generally uncommon. Penetrating blunt objects is rare. CT is a useful modality in diagnosis of head trauma in general and in diagnosis of penetrating foreign bodies especially. Unlike magnetic resonance imaging which is useful in special cases of head trauma with a penetrating foreign body. Case Report: We present a case in which a child presented at Sohag University hospital with falling from a height less than 2 meters causing penetration of the frontal bone of the skull by a stone on the land, which is a very rare presentation. The patient presented with scalp bleeding, post-concussion and disturbed conscious level. Vital signs were normal. A Computed Tomography scan (Multislice CT – 8 slices) of the skull was done with 3D reformatted images. Conclusion: Head trauma from penetrating objects (other than knife stapes or fire arm injuries) is uncommon. Blunt object penetration is very uncommon. It can be serious or even fatal. CT is the best imaging modality for diagnosis of such lesions. Metallic artifacts can be a limitation of their role. Although the finding is almost diagnostic, still the history and clinical finding is the key for diagnosis as the shape and density of the stone in some sections could be similar to ivory osteoma.
{"title":"Skull Penetrating Stone due to falling from height: A Case Report","authors":"Ahmad Mokhtar Abodahab, Ebtsam Ahmed Mohammed Abdelbary","doi":"10.21608/svuijm.2022.167431.1430","DOIUrl":"https://doi.org/10.21608/svuijm.2022.167431.1430","url":null,"abstract":": Background: Falling from height is a common condition that can occur in different age groups. Many types of injuries can occur due to it, such as skull fractures. Skull penetrating foreign bodies (other than fire arm injuries and explosives) are generally uncommon. Penetrating blunt objects is rare. CT is a useful modality in diagnosis of head trauma in general and in diagnosis of penetrating foreign bodies especially. Unlike magnetic resonance imaging which is useful in special cases of head trauma with a penetrating foreign body. Case Report: We present a case in which a child presented at Sohag University hospital with falling from a height less than 2 meters causing penetration of the frontal bone of the skull by a stone on the land, which is a very rare presentation. The patient presented with scalp bleeding, post-concussion and disturbed conscious level. Vital signs were normal. A Computed Tomography scan (Multislice CT – 8 slices) of the skull was done with 3D reformatted images. Conclusion: Head trauma from penetrating objects (other than knife stapes or fire arm injuries) is uncommon. Blunt object penetration is very uncommon. It can be serious or even fatal. CT is the best imaging modality for diagnosis of such lesions. Metallic artifacts can be a limitation of their role. Although the finding is almost diagnostic, still the history and clinical finding is the key for diagnosis as the shape and density of the stone in some sections could be similar to ivory osteoma.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82387569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.175851.1453
A. M. Hassan, S. Kamel, A. Torad, Amgad Hazzaa, A. Salama
{"title":"Effect of Wet Cupping Therapy on reducing blood pressure in primary hypertensive patients: A preliminary study","authors":"A. M. Hassan, S. Kamel, A. Torad, Amgad Hazzaa, A. Salama","doi":"10.21608/svuijm.2022.175851.1453","DOIUrl":"https://doi.org/10.21608/svuijm.2022.175851.1453","url":null,"abstract":"","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74577540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.156081.1378
Khaled Abdallah Abdelbasir, M. H. Hassan, Mahmoud Hasan Mahmoud, Ali Helmi Bakry
Background: The cornerstone of brain activity is changes in membrane voltage caused by ion fluxes through voltage and transmitter-gated channels. Therefore, electrochemical gradients across the membrane determine the direction and driving force for ion flow, which in turn establishes synaptic transmission and signal propagation parameters.Numerous methods create ion concentration gradients and specialised transporter proteins are among them. However, ionic fluxes via channels can alter transmembrane gradients during times of increased brain activity, which is projected to have an impact on the characteristics of ongoing synaptic transmission. Both healthy and unhealthy brain processes involve activity-induced alterations to ion concentration gradients. Patients with epilepsy display a variety of altered trace elements, electrolytes, and free radical scavenging enzyme statuses. Minerals play an important role in regulating ion concentration gradients through their various biological actions. Objectives: This review would contribute in increasing understanding of the role of minerals in childhood epilepsy and the different mechanisms by which different types of minerals modulate seizures in children. Conclusion: The serum level of various trace elements and heavy metals influences the impact of epilepsy. In infantile epilepsy, high calcium concentrations in epileptic neurons remain elevated during both the acute damage and chronic epilepsy phases, and they play a role in the maintenance of spontaneous recurrent seizures.
{"title":"Role of Minerals in Childhood Epilepsy","authors":"Khaled Abdallah Abdelbasir, M. H. Hassan, Mahmoud Hasan Mahmoud, Ali Helmi Bakry","doi":"10.21608/svuijm.2022.156081.1378","DOIUrl":"https://doi.org/10.21608/svuijm.2022.156081.1378","url":null,"abstract":"Background: The cornerstone of brain activity is changes in membrane voltage caused by ion fluxes through voltage and transmitter-gated channels. Therefore, electrochemical gradients across the membrane determine the direction and driving force for ion flow, which in turn establishes synaptic transmission and signal propagation parameters.Numerous methods create ion concentration gradients and specialised transporter proteins are among them. However, ionic fluxes via channels can alter transmembrane gradients during times of increased brain activity, which is projected to have an impact on the characteristics of ongoing synaptic transmission. Both healthy and unhealthy brain processes involve activity-induced alterations to ion concentration gradients. Patients with epilepsy display a variety of altered trace elements, electrolytes, and free radical scavenging enzyme statuses. Minerals play an important role in regulating ion concentration gradients through their various biological actions. Objectives: This review would contribute in increasing understanding of the role of minerals in childhood epilepsy and the different mechanisms by which different types of minerals modulate seizures in children. Conclusion: The serum level of various trace elements and heavy metals influences the impact of epilepsy. In infantile epilepsy, high calcium concentrations in epileptic neurons remain elevated during both the acute damage and chronic epilepsy phases, and they play a role in the maintenance of spontaneous recurrent seizures.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80902996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.158094.1392
K. M. Zaki, M. Abdelkareem, W. Abady, A. Nafady, Zeinab Abd El Razek El Tieb
Background: Systemic lupus erythematosus (SLE) is a persistent illness that results in inflammation of connective tissues, including cartilage and the lining of blood vessels, which give structures throughout the body their flexibility and strength. A multi-system autoimmune illness, SLE affects several organ systems. There are several phenotypes of the illness, and clinical symptoms in individuals may range from modest mucocutaneous signs to severe central nervous system involvement affecting multiple organs. SLE is an illness that develops along many immune-pathogenic pathways. Aim: To explore various phenotypes of SLE and possible role of anti-C1q antibodies in SLE Conclusion: Anti-C1q antibodies were strongly associated with lupus disease activity in SLE patients, suggesting that it may be a reliable, sensitive, and non-invasive serological marker for SLE patients with active SLE disease.
{"title":"Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article","authors":"K. M. Zaki, M. Abdelkareem, W. Abady, A. Nafady, Zeinab Abd El Razek El Tieb","doi":"10.21608/svuijm.2022.158094.1392","DOIUrl":"https://doi.org/10.21608/svuijm.2022.158094.1392","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a persistent illness that results in inflammation of connective tissues, including cartilage and the lining of blood vessels, which give structures throughout the body their flexibility and strength. A multi-system autoimmune illness, SLE affects several organ systems. There are several phenotypes of the illness, and clinical symptoms in individuals may range from modest mucocutaneous signs to severe central nervous system involvement affecting multiple organs. SLE is an illness that develops along many immune-pathogenic pathways. Aim: To explore various phenotypes of SLE and possible role of anti-C1q antibodies in SLE Conclusion: Anti-C1q antibodies were strongly associated with lupus disease activity in SLE patients, suggesting that it may be a reliable, sensitive, and non-invasive serological marker for SLE patients with active SLE disease.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88647241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.159934.1399
Ahmed Ismail Abdel Azeem, H. Mohamed, Salah Mostafa Asida, Mohammed Abdalrahman Soliman Ahmed
Background: Upper limb surgeries are frequently performed using peripheral nerve blocks, like ultra-sound guided supraclavicular brachial plexus block, which provides safe and effective anaesthesia. Search for safe and effective adjuvants to regional nerve blocks continues, with medication that increases the duration of analgesia although it has fewer side effects. Using of drugs as dexmedetomidine, opioids, ketamine, clonidine, midazolam, epinephrine, neostigmine, magnesium sulphate and dexamethasone along with local anaesthetics for this aim with different degrees of success. Objectives: This review research investigated safety and efficacy of various additives, namely dexmedetomidine, ketamine, fentanyl, and dexamethasone, when added to bupivacaine in ultrasound guided supraclavicular brachial plexus block in order to evaluate onset and duration of sensory and motor block, estimate sedation score, pain scale and total analgesic consumption and to investigate side effects when added to bupivacaine. Conclusion: This research implies that there is still to research about the of effect of different adjuvants added to bupivacaine in ultra-sound guided supraclavicular brachial plexus block.
{"title":"Ultra-sound guided supraclavicular brachial plexus block: The value of adjuvants: Review article","authors":"Ahmed Ismail Abdel Azeem, H. Mohamed, Salah Mostafa Asida, Mohammed Abdalrahman Soliman Ahmed","doi":"10.21608/svuijm.2022.159934.1399","DOIUrl":"https://doi.org/10.21608/svuijm.2022.159934.1399","url":null,"abstract":"Background: Upper limb surgeries are frequently performed using peripheral nerve blocks, like ultra-sound guided supraclavicular brachial plexus block, which provides safe and effective anaesthesia. Search for safe and effective adjuvants to regional nerve blocks continues, with medication that increases the duration of analgesia although it has fewer side effects. Using of drugs as dexmedetomidine, opioids, ketamine, clonidine, midazolam, epinephrine, neostigmine, magnesium sulphate and dexamethasone along with local anaesthetics for this aim with different degrees of success. Objectives: This review research investigated safety and efficacy of various additives, namely dexmedetomidine, ketamine, fentanyl, and dexamethasone, when added to bupivacaine in ultrasound guided supraclavicular brachial plexus block in order to evaluate onset and duration of sensory and motor block, estimate sedation score, pain scale and total analgesic consumption and to investigate side effects when added to bupivacaine. Conclusion: This research implies that there is still to research about the of effect of different adjuvants added to bupivacaine in ultra-sound guided supraclavicular brachial plexus block.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"185 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81051816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/svuijm.2022.165788.1422
Kranti S. Sorte Gawali, Avinash Jadhao, Manoj C. Lokhnade
Background: Various experimental evidence suggests that in cataract pathogenesis oxidative stress plays an important role in causing DNA damage, but there is still a lack of data on in vivo assessment of DNA damage and the role of antioxidants. Objectives: To measure the percentage of DNA damage and the total antioxidant capacity (TAC) of patients with cataracts directly in human lens epithelial cells and compare these with a control group followed by whether there is any statistical correlation between oxidative DNA damage and total antioxidant status in senile cataract patients. Patients and methods: A total number of capsulorhexis from thirty senile cataract cases aged 50-80 years, who were admitted to the ophthalmology ward of AVBRH for cataract surgery, were used for in vitro assessment of DNA damage in human lens epithelial cells by Comet assay and TAC assays. 12 controls were collected from healthy cadavers who or their relatives donated their eyes for TAC assays. Results : Oxidative DNA damage level of human lens epithelial cells is not correlated with the TAC in aqueous extract of HLECs in senile cataract patients . Conclusion: The conclusion in the present study should not be taken that supplementing antioxidants through diet has no role in the prevention of oxidative DNA damage against oxidants. There may be another mechanism may be responsible for oxidative DNA damage.
{"title":"Is the Oxidative DNA Damage Level of Human Lens Epithelial Cells Correlated with the Total Antioxidant Capacity (TAC) in Aqueous Extract of HLECs in Senile Cataract Patients?","authors":"Kranti S. Sorte Gawali, Avinash Jadhao, Manoj C. Lokhnade","doi":"10.21608/svuijm.2022.165788.1422","DOIUrl":"https://doi.org/10.21608/svuijm.2022.165788.1422","url":null,"abstract":"Background: Various experimental evidence suggests that in cataract pathogenesis oxidative stress plays an important role in causing DNA damage, but there is still a lack of data on in vivo assessment of DNA damage and the role of antioxidants. Objectives: To measure the percentage of DNA damage and the total antioxidant capacity (TAC) of patients with cataracts directly in human lens epithelial cells and compare these with a control group followed by whether there is any statistical correlation between oxidative DNA damage and total antioxidant status in senile cataract patients. Patients and methods: A total number of capsulorhexis from thirty senile cataract cases aged 50-80 years, who were admitted to the ophthalmology ward of AVBRH for cataract surgery, were used for in vitro assessment of DNA damage in human lens epithelial cells by Comet assay and TAC assays. 12 controls were collected from healthy cadavers who or their relatives donated their eyes for TAC assays. Results : Oxidative DNA damage level of human lens epithelial cells is not correlated with the TAC in aqueous extract of HLECs in senile cataract patients . Conclusion: The conclusion in the present study should not be taken that supplementing antioxidants through diet has no role in the prevention of oxidative DNA damage against oxidants. There may be another mechanism may be responsible for oxidative DNA damage.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78482184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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