Pub Date : 2022-12-28DOI: 10.21608/svuijm.2022.173458.1444
Mohamed Hussein Elrashidy, M. H. Hassan, Noher Mohamed Abass
Background : Hyperuricemia is associated with coronary artery disease (CAD). Hypoalbuminemia is a prognostic marker of many cardiovascular diseases, including CAD. Objectives: This study investigates the value of the uric acid-to-serum albumin ratio (UAR) as a non-invasive predictor of significant CAD. Patients and methods: This cross-sectional study included 100 non-diabetic, normotensive patients tested for CAD by coronary angiography. Serum uric acid and albumin were measured, and UAR was calculated. On coronary angiography, coronary stenosis > 50% in at least one of the major coronary arteries was considered significant. Results: Significant coronary stenosis was found in 57 patients. Significant stenosis was more frequent among males and smokers. Albumin was significantly lower in patients with significant stenosis, while uric acid, UAR, LDL, and triglycerides were significantly higher in patients with significant stenosis (p< 0.001, for all). Hypoalbuminemia was significantly associated with coronary stenosis (p = 0.002), while hyperuricemia was not (p=0.181). The sensitivity and specificity of hypoalbuminemia to predict coronary stenosis was 77.2% and 72.1%. UAR ≥ 1.56 predicts coronary stenosis with sensitivity and specificity of 71.9% and 74.4%. Albumin, uric acid, and UAR do not expect the severity of coronary affection. Conclusion : Hypoalbuminemia is a valuable marker for the likelihood of severe coronary stenosis. Hyperuricemia is not associated with coronary stenosis, and the uric acid-to-albumin ratio does not improve the predictive value of hypoalbuminemia in diagnosing significant coronary stenosis.
{"title":"Uric Acid-to-Albumin Ratio as a Non-Invasive predictor for the Severity of Coronary Atherosclerosis","authors":"Mohamed Hussein Elrashidy, M. H. Hassan, Noher Mohamed Abass","doi":"10.21608/svuijm.2022.173458.1444","DOIUrl":"https://doi.org/10.21608/svuijm.2022.173458.1444","url":null,"abstract":"Background : Hyperuricemia is associated with coronary artery disease (CAD). Hypoalbuminemia is a prognostic marker of many cardiovascular diseases, including CAD. Objectives: This study investigates the value of the uric acid-to-serum albumin ratio (UAR) as a non-invasive predictor of significant CAD. Patients and methods: This cross-sectional study included 100 non-diabetic, normotensive patients tested for CAD by coronary angiography. Serum uric acid and albumin were measured, and UAR was calculated. On coronary angiography, coronary stenosis > 50% in at least one of the major coronary arteries was considered significant. Results: Significant coronary stenosis was found in 57 patients. Significant stenosis was more frequent among males and smokers. Albumin was significantly lower in patients with significant stenosis, while uric acid, UAR, LDL, and triglycerides were significantly higher in patients with significant stenosis (p< 0.001, for all). Hypoalbuminemia was significantly associated with coronary stenosis (p = 0.002), while hyperuricemia was not (p=0.181). The sensitivity and specificity of hypoalbuminemia to predict coronary stenosis was 77.2% and 72.1%. UAR ≥ 1.56 predicts coronary stenosis with sensitivity and specificity of 71.9% and 74.4%. Albumin, uric acid, and UAR do not expect the severity of coronary affection. Conclusion : Hypoalbuminemia is a valuable marker for the likelihood of severe coronary stenosis. Hyperuricemia is not associated with coronary stenosis, and the uric acid-to-albumin ratio does not improve the predictive value of hypoalbuminemia in diagnosing significant coronary stenosis.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85474927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.21608/svuijm.2022.169296.1433
E. Dongol, H. Abdelkhalek, A. Y. Badawy, Islam El Malky
Background: Many patients with obstructive sleep apnea (OSA) report no improvement in the excessive daytime sleepiness, despite compliant CPAP treatment. Associated periodic limb movements (PLMs)with OSA might be a cause of failure. Objectives: Our study aimed to assess the increased periodic limb movements index (PLMI) in patients with residual excessive sleepiness (RES) on CPAP and polysomnographic changes caused by the occurrence of PLMs in this group of patients, and predictors of PLMS ’ s presence. Patients and methods: We searched the electronic medical records of the OSA patients who were followed up in the CPAP outpatient clinic between 2010-2015. Patients who had completed at least one year of treatment were assessed. We included only patients with OSA and RES due to only PLMs (45 patients) (group one) against patients with OSAS, RES and with no definite cause (11 patients) (group two). Result s: There was significant difference between both groups(more in group one) in the age and waist circumference (p value 0.04 and 0.017, respectively). There was significantly longer sleep onset latency (28.01 vs. 9.29), lower total sleep time (5.5 vs. 6.6 hours) and lower sleep efficiency percentage (72.44% vs. 87.1 %) in group one than in group two (P-value of 0.042, 0.019 and 0.011, respectively). Also, there were significantly higher means of wake after sleep onset (WASO) and total arousal index in group one than in group two. Waist circumference was the only predictor for increased PLMs index in this population study, by logistic regression with OR (95%CI) 0.168 (0.011-0.324). Conclusion : Increased PLMI during sleep significantly impact the polysomnographic variables. The waist circumference might be the only predictor of increased PLMs index.
{"title":"Effect of Periodic limb Movement on polysomnographic data of OSA patients on CPAP with residual sleepiness","authors":"E. Dongol, H. Abdelkhalek, A. Y. Badawy, Islam El Malky","doi":"10.21608/svuijm.2022.169296.1433","DOIUrl":"https://doi.org/10.21608/svuijm.2022.169296.1433","url":null,"abstract":"Background: Many patients with obstructive sleep apnea (OSA) report no improvement in the excessive daytime sleepiness, despite compliant CPAP treatment. Associated periodic limb movements (PLMs)with OSA might be a cause of failure. Objectives: Our study aimed to assess the increased periodic limb movements index (PLMI) in patients with residual excessive sleepiness (RES) on CPAP and polysomnographic changes caused by the occurrence of PLMs in this group of patients, and predictors of PLMS ’ s presence. Patients and methods: We searched the electronic medical records of the OSA patients who were followed up in the CPAP outpatient clinic between 2010-2015. Patients who had completed at least one year of treatment were assessed. We included only patients with OSA and RES due to only PLMs (45 patients) (group one) against patients with OSAS, RES and with no definite cause (11 patients) (group two). Result s: There was significant difference between both groups(more in group one) in the age and waist circumference (p value 0.04 and 0.017, respectively). There was significantly longer sleep onset latency (28.01 vs. 9.29), lower total sleep time (5.5 vs. 6.6 hours) and lower sleep efficiency percentage (72.44% vs. 87.1 %) in group one than in group two (P-value of 0.042, 0.019 and 0.011, respectively). Also, there were significantly higher means of wake after sleep onset (WASO) and total arousal index in group one than in group two. Waist circumference was the only predictor for increased PLMs index in this population study, by logistic regression with OR (95%CI) 0.168 (0.011-0.324). Conclusion : Increased PLMI during sleep significantly impact the polysomnographic variables. The waist circumference might be the only predictor of increased PLMs index.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82897881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-12DOI: 10.21608/svuijm.2022.155478.1374
Z. Ismael, Walaa Elsamman
{"title":"Evaluation of the Effects of Azithromycin on the Kidney of Adult Albino Rats and the Possible Protective Role of Vitamin C Using Histological and Immuno-Histochemical Studies","authors":"Z. Ismael, Walaa Elsamman","doi":"10.21608/svuijm.2022.155478.1374","DOIUrl":"https://doi.org/10.21608/svuijm.2022.155478.1374","url":null,"abstract":"","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87802819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.117027.1268
A. Ghweil, A. Okasha, M. Mahmoud, S. Bazeed
Background: Around the world, non-alcoholic fatty liver disease is the main cause of liver diseases. A substantial relationship between NAFLD and H.pylori infection has been discovered recently. Objectives: We aimed to explore the relationship between H.pylori infection and NAFLD in Egyptians. Patients and methods: A case-control study involved 200 patients who underwent Oesophagogastroduodenoscopy. We divided Participants into 2 groups: Group A: contained 100 patients with confirmed H Pylori infection, Group B: contained 100 patients without H.Pylori infection. We diagnosed Fatty liver by ultrasonography. Results: Our study results showed that prevalence of non-alcoholic fatty liver disease (NAFLD) was similar in patients with H.pylori infection in comparison to control group (16% Vs 12% in GroupA and B, respectively). We found that the prevalence of dyslipidemia was higher in patients with H.pylori infection in comparison to control group. Conclusion: There is no significant relationship between H.pylori infection and nonalcoholic fatty liver disease (NAFLD). Dyslipidemia was higher in patients with H.pylori infection than in healthy persons.
{"title":"Relation between Helicobacter pylori infection and non-alcoholic fatty liver Disease","authors":"A. Ghweil, A. Okasha, M. Mahmoud, S. Bazeed","doi":"10.21608/svuijm.2022.117027.1268","DOIUrl":"https://doi.org/10.21608/svuijm.2022.117027.1268","url":null,"abstract":"Background: Around the world, non-alcoholic fatty liver disease is the main cause of liver diseases. A substantial relationship between NAFLD and H.pylori infection has been discovered recently. Objectives: We aimed to explore the relationship between H.pylori infection and NAFLD in Egyptians. Patients and methods: A case-control study involved 200 patients who underwent Oesophagogastroduodenoscopy. We divided Participants into 2 groups: Group A: contained 100 patients with confirmed H Pylori infection, Group B: contained 100 patients without H.Pylori infection. We diagnosed Fatty liver by ultrasonography. Results: Our study results showed that prevalence of non-alcoholic fatty liver disease (NAFLD) was similar in patients with H.pylori infection in comparison to control group (16% Vs 12% in GroupA and B, respectively). We found that the prevalence of dyslipidemia was higher in patients with H.pylori infection in comparison to control group. Conclusion: There is no significant relationship between H.pylori infection and nonalcoholic fatty liver disease (NAFLD). Dyslipidemia was higher in patients with H.pylori infection than in healthy persons.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"35 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75883354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.146247.1327
Eisa Abdellah Ahmed, W. Etman, W. Hassanein, B. Ramadan
Background: The left internal mammary artery (IMA) is considered the cornerstone for grafting the left anterior descending (LAD) coronary artery with Pedicled and skeletonized techniques are the most commonly used harvesting techniques. Objectives: The aim of this work is to study the short term clinical outcomes of both techniques. Patients and methods: 100 patients requiring open heart surgery for isolated elective coronary artery bypass graft (CABG) were enrolled in this study. The patients were divided into two groups, 50 patients underwent pedicled left (IMA) harvesting and 50 patients underwent skeletonized left (IMA) harvesting, and all the patients had a 3-month follow-up. Results: There was no significant difference in patients ’ demographic data between groups. The pedicled group was associated with an increased rate of post operative drainage (pedicled group versus skeletonized group) (486.0 ± 321.99 versus 338.0 ± 241.29) (P-value <0.001). There was no significant difference between both groups in regard to the duration of ventilation, intensive care unit stay, and arrhythmia. There was no significant difference between both groups in regard to sternal wound complications at three months follow up. Conclusions: Pedicled left (IMA) and skeletonized left (IMA) short term outcomes are nearly equal except that the skeletonized technique is superior in regard to the amount of post operative drainage in comparison to the pedicled technique.
{"title":"Short Term Outcomes Of Pedicled Versus Skeletonized Internal Mammary Artery Grafts In Coronary Bypass Surgery","authors":"Eisa Abdellah Ahmed, W. Etman, W. Hassanein, B. Ramadan","doi":"10.21608/svuijm.2022.146247.1327","DOIUrl":"https://doi.org/10.21608/svuijm.2022.146247.1327","url":null,"abstract":"Background: The left internal mammary artery (IMA) is considered the cornerstone for grafting the left anterior descending (LAD) coronary artery with Pedicled and skeletonized techniques are the most commonly used harvesting techniques. Objectives: The aim of this work is to study the short term clinical outcomes of both techniques. Patients and methods: 100 patients requiring open heart surgery for isolated elective coronary artery bypass graft (CABG) were enrolled in this study. The patients were divided into two groups, 50 patients underwent pedicled left (IMA) harvesting and 50 patients underwent skeletonized left (IMA) harvesting, and all the patients had a 3-month follow-up. Results: There was no significant difference in patients ’ demographic data between groups. The pedicled group was associated with an increased rate of post operative drainage (pedicled group versus skeletonized group) (486.0 ± 321.99 versus 338.0 ± 241.29) (P-value <0.001). There was no significant difference between both groups in regard to the duration of ventilation, intensive care unit stay, and arrhythmia. There was no significant difference between both groups in regard to sternal wound complications at three months follow up. Conclusions: Pedicled left (IMA) and skeletonized left (IMA) short term outcomes are nearly equal except that the skeletonized technique is superior in regard to the amount of post operative drainage in comparison to the pedicled technique.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78184737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.128484.1299
S. Bazeed, H. Fayed, A. Hashim, Omima Rabea Abdelrady Abdelhady, Shimaa Arafat
: Background: Chronic kidney disease (CKD) and metabolic-associated fatty liver disease (MAFLD) are increasing chronic illnesses that contribute to a variety of major cardio-metabolic risk factors and pathogenic processes. Objectives: To estimate the frequency of MAFLD and its risk factors among CKD Patients in Upper Egypt. Patients and methods: a case-control study entangled 200 individuals with CKD and 60 person without as a control. All participants underwent a thorough history, physical examination, and laboratory testing which incorporate complete blood count, assessment of neutrophil-lymphocyte ratio (NLR), liver enzymes (ALT, AST), kidney function, estimated glomerular filtration rate (eGFR), and lipid profile. Pelvic-abdominal ultrasound and fibroscan were executed. Results: We found a significantly increased proportion of MAFLD, HbA1c and NLR values in the cases group when compared with the control group, where a high prevalence of steatosis and liver stiffness among CKD patients. Multivariate logistic regression analysis demonstrated that high BMI, elevated LDL, elevated liver enzymes (AST & ALT) were predictive risk factors for the existence of MAFLD in the CKD patients. Conclusion: There is a statistically significant correlation between CKD and MAFLD in the form of increased prevalence of MAFLD in CKD patients.
{"title":"Frequency of Metabolic Associated Fatty Liver Disease among Chronic Kidney Disease Patients in Upper Egypt","authors":"S. Bazeed, H. Fayed, A. Hashim, Omima Rabea Abdelrady Abdelhady, Shimaa Arafat","doi":"10.21608/svuijm.2022.128484.1299","DOIUrl":"https://doi.org/10.21608/svuijm.2022.128484.1299","url":null,"abstract":": Background: Chronic kidney disease (CKD) and metabolic-associated fatty liver disease (MAFLD) are increasing chronic illnesses that contribute to a variety of major cardio-metabolic risk factors and pathogenic processes. Objectives: To estimate the frequency of MAFLD and its risk factors among CKD Patients in Upper Egypt. Patients and methods: a case-control study entangled 200 individuals with CKD and 60 person without as a control. All participants underwent a thorough history, physical examination, and laboratory testing which incorporate complete blood count, assessment of neutrophil-lymphocyte ratio (NLR), liver enzymes (ALT, AST), kidney function, estimated glomerular filtration rate (eGFR), and lipid profile. Pelvic-abdominal ultrasound and fibroscan were executed. Results: We found a significantly increased proportion of MAFLD, HbA1c and NLR values in the cases group when compared with the control group, where a high prevalence of steatosis and liver stiffness among CKD patients. Multivariate logistic regression analysis demonstrated that high BMI, elevated LDL, elevated liver enzymes (AST & ALT) were predictive risk factors for the existence of MAFLD in the CKD patients. Conclusion: There is a statistically significant correlation between CKD and MAFLD in the form of increased prevalence of MAFLD in CKD patients.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"473 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79925699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.163413.1409
Dorrya Zaghloul, Eman Ahmad AbdErahim, Basma Ashraf Yousef Abd El_Raheem, M. Mohamed
Background : The thymus is the location of T cell development, where lymphoid precursors mature and are exported to the periphery through a sequence of interactions with the thymic epithelium. Objectives : To assess the anatomical and histological study on the development of the thymus in the embryo and adult mice. Materials and methods: This study was developmental; fifty mice were divided randomly into 5 groups; group A: Pregnant female mice were dissected at the end of the 1 st week of gestation to get their embryos. Group B: Pregnant female mice were dissected at the end of the 2 nd week of gestation to get their embryos. Group C: Pregnant female mice were left to deliver their fetuses. Group D: Fetuses was left to complete their 1 st week. Group E was designed as the control group in which the adult male and female mice were dissected and prepared for histological examination to compare their thymus with the embryonic and fetal thymus. Results: All animals of the group A had no thymus gland while all the other mice had thymus gland. Thymus appeared lobulated with no differentiation between the cortex and the medulla in the newborn age. Hassle's corpuscles could be detected at the 6 th postnatal age. Conclusion : Age-related differences in the morphology and histology of TH reflects the development of T cell and immunity and its crucial role in immune disorders. Mice TH gain full maturity by the end of 1 st postnatal week and involution appears in the 6 th postnatal week of age. The distinction between the medulla and cortex gradually disappears as people age.
{"title":"Anatomical and histological study on thymus development in the embryo and adult mice","authors":"Dorrya Zaghloul, Eman Ahmad AbdErahim, Basma Ashraf Yousef Abd El_Raheem, M. Mohamed","doi":"10.21608/svuijm.2022.163413.1409","DOIUrl":"https://doi.org/10.21608/svuijm.2022.163413.1409","url":null,"abstract":"Background : The thymus is the location of T cell development, where lymphoid precursors mature and are exported to the periphery through a sequence of interactions with the thymic epithelium. Objectives : To assess the anatomical and histological study on the development of the thymus in the embryo and adult mice. Materials and methods: This study was developmental; fifty mice were divided randomly into 5 groups; group A: Pregnant female mice were dissected at the end of the 1 st week of gestation to get their embryos. Group B: Pregnant female mice were dissected at the end of the 2 nd week of gestation to get their embryos. Group C: Pregnant female mice were left to deliver their fetuses. Group D: Fetuses was left to complete their 1 st week. Group E was designed as the control group in which the adult male and female mice were dissected and prepared for histological examination to compare their thymus with the embryonic and fetal thymus. Results: All animals of the group A had no thymus gland while all the other mice had thymus gland. Thymus appeared lobulated with no differentiation between the cortex and the medulla in the newborn age. Hassle's corpuscles could be detected at the 6 th postnatal age. Conclusion : Age-related differences in the morphology and histology of TH reflects the development of T cell and immunity and its crucial role in immune disorders. Mice TH gain full maturity by the end of 1 st postnatal week and involution appears in the 6 th postnatal week of age. The distinction between the medulla and cortex gradually disappears as people age.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78963947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Interstitial lung diseases (ILD) may be manifested with extra-articular manifestations in rheumatoid arthritis patients; these manifestations may be occur as a preceding entity or several years after the RA diagnosis and can cause important effect on morbidity and mortality. Objectives: is to evaluate the Patterns of pulmonary manifestations in ILDs in rheumatoid arthritis Patients and methods: This is cross-sectional study was conducted at Qena university hospital, South Valley University, Qena through evaluation of 50 rheumatoid arthritis patients were selected from those attending the outpatient clinic and those admitted in the inpatients of Physical Medicine, Rheumatology and Rehabilitation Department at Qena University Hospital. Results: Mean morning stiffness is 42.2 ± 18.77 minute and the most prevalent symptom presented was subcutaneous nodules (60%) followed by dryness of the mouth (16%). Conclusion: Interstitial lung diseases caused by rheumatoid arthritis is a serious complication of RA causing increased morbidity and mortality.
{"title":"The Patterns of pulmonary manifestations in ILDs in rheumatoid arthritis","authors":"Mohammad Ismail Abdelkareem, Wael Abdelmohsen Abo zaid, Hagagy Mansour, Fatma Hussein","doi":"10.21608/svuijm.2022.126764.1293","DOIUrl":"https://doi.org/10.21608/svuijm.2022.126764.1293","url":null,"abstract":"Background : Interstitial lung diseases (ILD) may be manifested with extra-articular manifestations in rheumatoid arthritis patients; these manifestations may be occur as a preceding entity or several years after the RA diagnosis and can cause important effect on morbidity and mortality. Objectives: is to evaluate the Patterns of pulmonary manifestations in ILDs in rheumatoid arthritis Patients and methods: This is cross-sectional study was conducted at Qena university hospital, South Valley University, Qena through evaluation of 50 rheumatoid arthritis patients were selected from those attending the outpatient clinic and those admitted in the inpatients of Physical Medicine, Rheumatology and Rehabilitation Department at Qena University Hospital. Results: Mean morning stiffness is 42.2 ± 18.77 minute and the most prevalent symptom presented was subcutaneous nodules (60%) followed by dryness of the mouth (16%). Conclusion: Interstitial lung diseases caused by rheumatoid arthritis is a serious complication of RA causing increased morbidity and mortality.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88532440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.141312.1320
Yasser M. Kamal, Adel I. Abd Elaziz, Mohamed Eid
Background: Patients suffering from type 2 diabetes (T2DM) have a 2 – 6 times higher risk of dying from cardiovascular disease than people without diabetes. While macrovascular disease is the main pathogenic mechanism behind coronary artery disease in the general population, microvascular disease may play a significant role in the development of CAD in diabetics. Coronary artery disease is a leading cause of mortality in diabetics. Microalbuminuria to chronic kidney disease (CKD) can result from diabetic nephropathy, which is caused by persistently poor glycemic management. It is unclear how microalbuminuria and cardiovascular disease are related, but one theory suggests that it has to do with the growing transvascular leakiness of albumin in the systemic and renal arteries. A well-known micro-angiopathic consequence of DM with a strong correlation to cardiovascular risk factors is diabetic retinopathy. Objectives: To assess the association between the microvascular complications and the severity of CAD determined by coronary angiography in patients with T2DM. Patients and Methods: This study was conducted on 70 cases with T2DM who were admitted for coronary angiography due to suspected CAD and then divided into 41 patients diagnosed with nephropathic,and 29 non-nephropathy patients. Then Patients were divided into retinopathic and non-retinopathic groups 36 patients diagnosed with retinopathy and 34 non-retinopathic patients. All patients were subjected to full history, clinical examination, lab investigations and cardiac catheterization using the Genseni score system to detect the severity of coronary artery disease. Results: Gensini score was significantly higher in the nephropathy group compared to the non-nephropathy group. The Vessel score was insignificantly different between the two groups. Gensini score was significantly higher in the retinopathy group compared to the non-retinopathy group. Vessel score was significantly higher in the retinopathy group compared to the non-retinopathy group. Conclusion : In patients with type 2 DM subjected to coronary angiography because of suspected (CAD), duration of DM, creatinine, HbA1c, and Gensini score were significantly higher in the nephropathic group compared to the non-nephropathic group. Further, duration of DM, HbA1c. Gensini score and vessel score were significantly higher in the retinopathy group compared to the non-retinopathy group. Microvascular diabetic complications with retinopathy and nephropathy were significantly associated with the severity of CAD determined by coronary angiography.
{"title":"Correlation between microvascular complications and severity of coronary artery disease in patients with type 2 DM","authors":"Yasser M. Kamal, Adel I. Abd Elaziz, Mohamed Eid","doi":"10.21608/svuijm.2022.141312.1320","DOIUrl":"https://doi.org/10.21608/svuijm.2022.141312.1320","url":null,"abstract":"Background: Patients suffering from type 2 diabetes (T2DM) have a 2 – 6 times higher risk of dying from cardiovascular disease than people without diabetes. While macrovascular disease is the main pathogenic mechanism behind coronary artery disease in the general population, microvascular disease may play a significant role in the development of CAD in diabetics. Coronary artery disease is a leading cause of mortality in diabetics. Microalbuminuria to chronic kidney disease (CKD) can result from diabetic nephropathy, which is caused by persistently poor glycemic management. It is unclear how microalbuminuria and cardiovascular disease are related, but one theory suggests that it has to do with the growing transvascular leakiness of albumin in the systemic and renal arteries. A well-known micro-angiopathic consequence of DM with a strong correlation to cardiovascular risk factors is diabetic retinopathy. Objectives: To assess the association between the microvascular complications and the severity of CAD determined by coronary angiography in patients with T2DM. Patients and Methods: This study was conducted on 70 cases with T2DM who were admitted for coronary angiography due to suspected CAD and then divided into 41 patients diagnosed with nephropathic,and 29 non-nephropathy patients. Then Patients were divided into retinopathic and non-retinopathic groups 36 patients diagnosed with retinopathy and 34 non-retinopathic patients. All patients were subjected to full history, clinical examination, lab investigations and cardiac catheterization using the Genseni score system to detect the severity of coronary artery disease. Results: Gensini score was significantly higher in the nephropathy group compared to the non-nephropathy group. The Vessel score was insignificantly different between the two groups. Gensini score was significantly higher in the retinopathy group compared to the non-retinopathy group. Vessel score was significantly higher in the retinopathy group compared to the non-retinopathy group. Conclusion : In patients with type 2 DM subjected to coronary angiography because of suspected (CAD), duration of DM, creatinine, HbA1c, and Gensini score were significantly higher in the nephropathic group compared to the non-nephropathic group. Further, duration of DM, HbA1c. Gensini score and vessel score were significantly higher in the retinopathy group compared to the non-retinopathy group. Microvascular diabetic complications with retinopathy and nephropathy were significantly associated with the severity of CAD determined by coronary angiography.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86704143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/svuijm.2022.131434.1301
O. Galal, Ahmed Mostafa, Haytham Mohamed, A-Halim R. Ahmed, Marwa Hashim, Nagwa Abd Mohamed
Background : Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D. Objectives : The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model. Materials and method : the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile. Results : isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D. Conclusion : vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D.
背景:心血管疾病(CVD)是一个公共卫生问题，2019年全球有1790万人死亡。维生素D是一种脂溶性维生素，具有多种心脏保护作用，缺乏维生素D与多种心血管疾病有关。纳米维生素D系统可以克服口服维生素D的可变生物利用度、水溶性差和化学降解等问题。目的:在异丙肾上腺素诱导心肌梗死(MI)大鼠模型上评价口服维生素D和纳米维生素D的潜在心脏保护作用。材料和方法:本研究评估了维生素D和维生素D纳米颗粒对心肌梗死率模型的影响。异丙肾上腺素100 mg/ kg在30天治疗期的最后2天诱发心肌梗死。我们分析了心脏损伤、脂质过氧化标志物和脂质谱。结果:异丙肾上腺素处理大鼠心肌肌钙蛋白- i (cTn-I)、丙二醛(MDA)明显升高(p值<0.0001)。口服维生素D可降低ctn - 1和MDA水平，改善血脂。结论:与口服常规维生素D相比，维生素D纳米颗粒对异丙肾上腺素诱导的心肌梗死具有更有效的心脏保护作用。
{"title":"Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model","authors":"O. Galal, Ahmed Mostafa, Haytham Mohamed, A-Halim R. Ahmed, Marwa Hashim, Nagwa Abd Mohamed","doi":"10.21608/svuijm.2022.131434.1301","DOIUrl":"https://doi.org/10.21608/svuijm.2022.131434.1301","url":null,"abstract":"Background : Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D. Objectives : The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model. Materials and method : the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile. Results : isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D. Conclusion : vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77329102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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