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Comparative Study between Intrapolyp Corticosteroid Injection and Oral Corticosteroid in Treatment of Allergic Nasal Polyposis 鼻息肉内注射皮质类固醇与口服皮质类固醇治疗变应性鼻息肉病的比较研究
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.195800.1540
N. Abdelrahman, A. Abdelraheem, Rehab Abd El Hakim Amin, Mahmoud Khalefa
: Background: Sino-nasal polyps can be treated medically (with systemic and local steroids) or surgically; but a lot of patients refuse surgical intervention or are contraindicated to use systemic steroids. Intra-polyp steroid injections have recently been utilized to deliver high concentrations of steroid directly into the nasal polyp while simultaneously shielding the patient from the systemic steroid side effects. Objectives: To assess the role and efficacy of intra-polyp injection of steroids in the management of allergic nasal polypi, as well as to compare these findings to those of oral steroid. Patients and methods : Our study involved sixty patients that attended the outpatient clinic of the ENT department at Qena University Hospital who diagnosed with allergic nasal polypi. Their ages ranged from 17 to 63 years. They were randomly divided into 2 groups (oral steroid and intra-polyp steroid injection) according to type of treatment, each consisting of 30 patients. Results : After treatment, both groups showed a statistically significant decrease in the Symptom Score, Polyp Score, and Lund-Mackay score (P <0.001), with a significant difference between them (P < 0.001). Conclusion: Intra-polyp injection of steroid appears to be a safe and effective treatment method for Sino- nasal polyposis, with results comparable to systemic corticosteroids.
背景:鼻息肉可以药物治疗(全身和局部类固醇)或手术治疗;但许多患者拒绝手术治疗或禁用全身性类固醇。息肉内类固醇注射最近被用于将高浓度类固醇直接注入鼻息肉,同时保护患者免受全身类固醇副作用的影响。目的:评价鼻息肉内注射类固醇治疗变应性鼻息肉的作用和疗效,并将其与口服类固醇治疗效果进行比较。患者和方法:我们的研究涉及60名在Qena大学医院耳鼻喉科门诊就诊的诊断为过敏性鼻息肉的患者。他们的年龄从17岁到63岁不等。按治疗方式随机分为口服类固醇和息肉内注射类固醇2组,每组30例。结果:治疗后,两组患者的症状评分、息肉评分、Lund-Mackay评分均降低,差异有统计学意义(P <0.001),两组间差异有统计学意义(P <0.001)。结论:鼻息肉内注射类固醇是一种安全有效的治疗鼻息肉病的方法,其效果与全身皮质类固醇相当。
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引用次数: 0
Evaluation of different methods of performing cell block preparation and their role in accurate cytological diagnosis and reporting of fine needle aspiration cytology of the thyroid nodules 评价细胞阻滞制备的不同方法及其在甲状腺结节的准确细胞学诊断和细针穿刺细胞学报告中的作用
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.207123.1574
Mahmoud Gamal Ameen Taher, M. Wahman, S. Fadel, Basma Tito Abdelhameed
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引用次数: 0
The Impact of Restrictive Versus Conservative Intraoperative Fluid Strategies upon the Renal Outcome in Colorectal Surgeries. A Randomized Controlled Trial 结直肠手术中限制性与保守性术中液体策略对肾脏预后的影响。随机对照试验
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.178375.1462
Khaled A. Abdelrahman, J. Sayed, M. I. Seddik, A. M. Thabet, Mohamed Abdallah AbdelNaser
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引用次数: 0
Early Outcomes of video-assisted thoracoscopic management of secondary spontaneous pneumothorax 电视胸腔镜治疗继发性自发性气胸的早期疗效
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.211732.1586
H. Ahmed, A. Ashry, Mohammed A. El-Hag-Aly
Background: Secondary spontaneous pneumothorax (SSP) is a presence of air in the pleural cavity due to underlying lung disease. Thoracotomy was the typical surgical technique for managing pneumothorax. However, video-assisted thoracoscopic surgery (VATS) became a standard for spontaneous pneumothorax treatment. Objectives: Assessment of VATS effectiveness and safety in the management of secondary spontaneous pneumothorax. Patients and methods : 96 patients with secondary pneumothorax underwent video-assisted thoracoscopic surgery for persistent air leak for more than 7 days or having a recurrent pneumothorax on the same side. A retrospective analysis of the patient's clinical characteristic data, perioperative outcome, and recurrence was performed. Results: 96 patients, the mean age was 61.1±11.7 years. 33 (32.3%) patients had a single attack and 63 (67.7%) patients had recurrent attacks of SPP. All patients had 3 ports of VATS surgery which included bullectomy and talc pleurodesis. Post-operative complications occurred in 37.5% of the patients. 31.3% experienced persistent air leak for more than 7 days after the surgery and 3.1 % had empyema due to prolonged air leak. Post-operative long hospital stay was significantly correlated with BMI (p=0.003), ASA grade (p=0.017), current smoking (p=0.016), and post-operative complication (p=0.001) in univariate analysis. In multivariate analysis, postoperative complication (p=0.001) and body mass index (BMI) was the only significant risk factors for a long hospital stay. Conclusion: Patients who had thoracoscopic surgery for the management of secondary spontaneous pneumothorax had a shorter length of hospitalization and a lower incidence of recurrence. High BMI and post-operative complications are risk factors for prolonged hospital stay.
背景:继发性自发性气胸(SSP)是由肺部疾病引起的胸膜腔内存在空气。开胸是治疗气胸的典型手术方法。然而,电视胸腔镜手术(VATS)成为自发性气胸治疗的标准。目的:评价VATS治疗继发性自发性气胸的有效性和安全性。患者与方法:96例继发性气胸患者因持续漏气7天以上或同侧复发性气胸,均行电视胸腔镜手术治疗。回顾性分析患者的临床特征资料、围手术期结果和复发情况。结果:96例患者,平均年龄61.1±11.7岁。SPP单次发作33例(32.3%),反复发作63例(67.7%),均行大泡切除、滑石胸膜固定术3路VATS手术。术后并发症发生率为37.5%。31.3%的患者术后持续漏气7天以上,3.1%的患者术后因漏气时间过长而出现脓胸。单因素分析显示,术后住院时间与BMI (p=0.003)、ASA分级(p=0.017)、吸烟史(p=0.016)、术后并发症(p=0.001)显著相关。在多因素分析中,术后并发症(p=0.001)和体重指数(BMI)是长时间住院的唯一显著危险因素。结论:经胸腔镜手术治疗继发性自发性气胸患者住院时间短,复发率低。高BMI和术后并发症是延长住院时间的危险因素。
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引用次数: 0
The effect of the modified Glasgow prognostic score in metastatic gastric cancer 改良格拉斯哥预后评分在转移性胃癌中的作用
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.201018.1554
A. Ozveren, Mustafa Şahbazlar
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引用次数: 0
A Comparison between single-dose pregabalin and magnesium sulfate in induced hypotension during functional endoscopic sinus surgery: A prospective randomized double-blinded study 单剂量普瑞巴林和硫酸镁在功能性内窥镜鼻窦手术中诱导低血压的比较:一项前瞻性随机双盲研究
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2022.180059.1470
Sarah M. Omar Mousa, Eman Gamal Hassan, Khalid Ahmed Abdo
Background: Functional Endoscopic sinus surgery (FESS) is a surgical intervention during which controlled hypotension can improve visibility. Magnesium sulfate is used for controlled hypotension. Pregabalin is also effective in hypotensive anesthesia. Objectives: This study aimed to detect the effect of single preoperative oral pregabalin versus intravenous magnesium sulfate to facilitate induced hypotension during functional endoscopic sinus surgery. Patients and methods: In a randomized, double-blind, prospective study, 60 patients of either sex were divided into 2 equal groups. Group P received an oral pregabalin capsule of 150 mg 30 minutes before general anesthesia. Group M received a single-dose 2 grams of magnesium sulfate 30 minutes before induction of anesthesia. The primary outcome was the total intraoperative consumption of nitroglycerin required to maintain the mean arterial blood pressure (MAP) at the range of 55 – 65 mmHg. The secondary outcomes were the quality of the surgical field assessed by the Fromm and Boezaart grading scale, surgeon satisfaction assessed by the five-point Likert scale, and the visual analog pain scores (VAS). Results : The pregabalin group P showed statistically significant lower nitroglycerine doses (1.3±1.2 mg) compared to group M (3.3±1.5 mg) with a P value of <0.001. The surgical field quality and the surgeon satisfaction scales showed statistically significant better scores in group P (1.7±0.6 and 5±0.6 respectively) than in group M (3.2±0.9 and 2.1±0.6 respectively) with P values of (0.023 and 0.001 respectively). The VAS showed statistically significant lower scores in group P (1.3±0.9) compared with group M (3.4±0.6) with a p value= 0.001. Conclusion: A single preoperative pregabalin dose was more effective than magnesium sulfate in reducing the total intraoperative consumption of nitroglycerin. It also provides a dryer surgical field that achieves better surgeon satisfaction and provides postoperative analgesia.
背景:功能性内窥镜鼻窦手术(FESS)是一种手术干预,控制低血压可以提高能见度。硫酸镁用于控制低血压。普瑞巴林在低血压麻醉中也有效。目的:本研究旨在检测术前单次口服普瑞巴林与静脉注射硫酸镁对功能内窥镜鼻窦手术诱导低血压的影响。患者和方法:在一项随机、双盲、前瞻性研究中,60名男女患者被分为两组。P组患者全麻前30分钟口服普瑞巴林胶囊150 mg。M组在麻醉诱导前30分钟给予硫酸镁单剂量2 g。主要终点是术中硝酸甘油的总消耗量,以维持平均动脉血压(MAP)在55 - 65 mmHg的范围内。次要结果为手术视野质量(采用Fromm和Boezaart评分法)、外科医生满意度(采用李克特五点评分法)和视觉模拟疼痛评分(VAS)。结果:普瑞巴林P组硝酸甘油剂量(1.3±1.2 mg)低于M组(3.3±1.5 mg), P值<0.001。手术野质量和外科医生满意度评分P组(分别为1.7±0.6和5±0.6)优于M组(分别为3.2±0.9和2.1±0.6),P值分别为(0.023和0.001)。VAS评分显示,P组(1.3±0.9)分低于M组(3.4±0.6)分,差异有统计学意义,P值= 0.001。结论:术前单剂量普瑞巴林比硫酸镁更有效地减少术中硝酸甘油的总消耗量。它还提供了一个干燥的手术场,达到更好的外科医生的满意度,并提供术后镇痛。
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引用次数: 0
Usefulness of Urine Uric Acid/Creatinine Ratio in Neonate as an Early Detector of Perinatal Hypoxia: A Hospital-Based Observational Study 新生儿尿尿酸/肌酐比值作为围产期缺氧早期检测的有效性:一项基于医院的观察研究
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.193729.1524
Saikat Mondal, Kanailai Barik, Sudipto Paul, S. Laha, Sayan Bera
Background : When a neonate is born under a hypoxic state, there is increased production of uric acid due to hypoxic tissue damage, which is excreted via the kidney, and the ratio of uric acid and creatinine (UA/Cr) in urine is used as an early predictor of perinatal hypoxia. Objectives : We conducted this study to compare urine UA/Cr ratio between normal and asphyxiated newborns and between different stages of HIE to evaluate its usefulness as a diagnostic and prognostic marker of perinatal asphyxia . Patients and method: This observational cross-sectional study is conducted for one year with 75 asphyxiated neonates in different stages of HIE and 75 healthy neonates as control. Uric acid and creatinine values are measured with an auto-analyzer from a single urine sample taken between 6 to 24 hours of birth. Results: We found urine UA(38 ±2.81 mg/dl vs 19.24±0.75 mg/dl ) and urine UA/Cr value (2.81±0.32 vs 1.40±0.13 ) significantly high in cases compared to control. Also, the urine UA and UA/Cr values are increasing with advanced stages of HIE (p <0.001). The optimal cut point value to predict HIE was at urine UA/Cr ratio of >2.45 with an AUC of 0.96, accuracy of 90%, sensitivity of 98.07% , specificity of 85.70% , PPV 78.46%, and NPV 98.82%. Conclusion: Urine UA/Cr appears to be a simple, inexpensive and reliable indicator of perinatal hypoxia for risk stratification based on functional impairment in the HIE babies.
背景:当新生儿在缺氧状态下出生时,由于缺氧组织损伤,尿酸的产生增加,尿酸通过肾脏排出,尿液中尿酸和肌酐(UA/Cr)的比值被用作围产期缺氧的早期预测指标。目的:我们进行了这项研究,比较正常新生儿和窒息新生儿以及HIE不同阶段的尿UA/Cr比值,以评估其作为围产期窒息诊断和预后指标的有效性。患者和方法:本观察性横断面研究以75例HIE不同阶段窒息新生儿和75例健康新生儿为对照,为期一年。尿酸和肌酐值是用自动分析仪从出生后6至24小时内采集的单个尿液样本中测量的。结果:尿UA(38±2.81 mg/dl vs 19.24±0.75 mg/dl)和尿UA/Cr值(2.81±0.32 vs 1.40±0.13)显著高于对照组。尿UA和UA/Cr值随HIE晚期升高(p 2.45, AUC为0.96,准确性为90%,敏感性为98.07%,特异性为85.70%,PPV为78.46%,NPV为98.82%)。结论:尿UA/Cr可作为HIE患儿围生期缺氧风险分层的一种简单、廉价、可靠的指标。
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引用次数: 0
Greater Occipital Nerve Block or Suboccipital Intramuscular Injections are effective for management of Postdural Puncture Headache: A placebo-controlled study 枕大神经阻滞或枕下肌内注射对硬脊膜穿刺后头痛有效:一项安慰剂对照研究
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.190092.1512
Islam A. Shaboob, S. Salman
Background: Postdural puncture headache (PDPH) is not uncommon complication of neuroaxial anesthesia and it affects the mother and the newborn. PDPH may be resistant to conservative management and requires intervention. Objectives: To evaluate the outcomes of bilateral greater occipital nerve block (GONB) and bilateral suboccipital intramuscular injection in a placebo-controlled study for management of PDPH. Patients and methods: 50 patients received bilateral saline injection, 32 patients received suboccipital intramuscular injection and 33 patients received GONB using a mixture of 40 mg lidocaine and 8 mg dexamethasone injection . Pain severity was assessed using the Numeric Rating Scale at baseline and weekly for 4-wks and monthly for 6-m after block, Pain-induced disability was assessed using the Oswestry Pain Disability Questionnaire (OPDQ) score and analgesic requirements were graded at baseline, 1, 3-and 6-m after block. The success rate was defined at the end of 6-m follow-up as the frequency of patients who stopped consumption of analgesia and/or had minimal-to-mild disability with OPDQ score of <20. Results: The success rates were 46.2% depending on number of women had stopped analgesia and 52.3% depending on the OPDQ score and was significantly higher among patients received GONB. Patients' distribution according to satisfaction grade was significantly higher in study groups than control groups with non-significant differences between the study groups. Conclusion: The applied procedures are effective for reducing pain severity, consumption of analgesics and improving disability. GONB provided significantly higher success rate,
背景:硬脊膜穿刺后头痛(PDPH)是神经轴麻醉的一种常见并发症,可影响产妇和新生儿。PDPH可能抵抗保守治疗,需要干预。目的:评价双侧枕大神经阻滞(GONB)和双侧枕下肌内注射治疗PDPH的安慰剂对照研究结果。患者和方法:50例患者双侧生理盐水注射,32例患者枕下肌内注射,33例患者采用利多卡因+地塞米松注射液8 mg混合的GONB。疼痛严重程度在基线、阻滞后4周每周和阻滞后6 m每月使用数字评定量表进行评估,疼痛引起的残疾使用Oswestry疼痛残疾问卷(OPDQ)评分进行评估,镇痛需求在基线、阻滞后1、3和6 m进行分级。在6 m随访结束时,成功率定义为停止使用镇痛药和/或OPDQ评分<20的患者有轻微至轻度残疾的频率。结果:以停药次数为标准的成功率为46.2%,以OPDQ评分为标准的成功率为52.3%,在接受GONB治疗的患者中成功率明显较高。研究组患者满意度分布明显高于对照组,组间差异无统计学意义。结论:所采用的手术方法对减轻疼痛程度、镇痛药的使用和改善残疾是有效的。GONB的成功率明显更高;
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引用次数: 0
Assessment of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography Before and After Ranibizumab Intravitreal Injection in Patients with Diabetic Macular Edema 利用光学相干断层扫描评估糖尿病黄斑水肿患者雷尼单抗玻璃体内注射前后视网膜神经纤维层厚度
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.181236.1475
Amr Khaled Mohammed Emam Hassan, Ahmed A Mohalhal, Osama Abdelmoneim Elsoghair Ali, A. Aldghaimy
{"title":"Assessment of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography Before and After Ranibizumab Intravitreal Injection in Patients with Diabetic Macular Edema","authors":"Amr Khaled Mohammed Emam Hassan, Ahmed A Mohalhal, Osama Abdelmoneim Elsoghair Ali, A. Aldghaimy","doi":"10.21608/svuijm.2023.181236.1475","DOIUrl":"https://doi.org/10.21608/svuijm.2023.181236.1475","url":null,"abstract":"","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81792777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The incidence of Iron Deficiency Anemia in Allergic Rhinitis patients in Qena University Hospital Qena大学医院变应性鼻炎患者缺铁性贫血的发生率分析
Pub Date : 2023-07-01 DOI: 10.21608/svuijm.2023.195475.1535
U. Taya, A. Abdelraheem, Reham Farouk Sayed, A. Selim, Mahmoud Khalefa
Background: Allergic rhinitis is a common disease of immune origin. It affects the quality of life of patients negatively. Objectives: To evaluate the changes in iron profile in allergic rhinitis patients. Patients and methods : This study was conducted on thirty patients with allergic rhinitis. All of the participants were subjected to clinical evaluation and the following investigations: Complete blood picture, Serum ferritin, Serum iron and total iron binding capacity (TIBC) and IgE. Visual analogue scale (VAS) score was used to measure the severity of allergic rhinitis. Results : Among the studied patients, there were 18 males (60%) and 12 females (40%), the mean age of studied patients was 11.3 ± 4.2 (SD) years with mean onset age of 4.6 ± 3.01(SD) years and mean duration of disease of 6.7 ± 2.9 years. There were 8 patients (26.7%) with positive family history in the studied patients. The incidence of iron deficiency and iron deficiency anemia was significantly higher in children with severe allergic rhinitis compared with mild cases. Also we found statistically significant difference (p-value = 0.037) between mild, moderate & severe cases of allergic rhinitis as regard Hb, MCH, HCT, ferritin, serum iron and TIBC. A statistically significant difference (p-value = 0.015) was noted between mild, moderate & severe cases as regard IgE. Serum IgE is correlated with the severity of allergic rhinitis in children. Conclusion : Prevalence of iron deficiency anemia in pediatric patients with allergic rhinitis is higher than in patients without atopic disease. Iron deficiency anemia increases markedly with severity of allergic rhinitis. Serum IgE is correlated with the severity of allergic rhinitis in children.
背景:变应性鼻炎是一种常见的免疫源性疾病。它对患者的生活质量产生负面影响。目的:探讨变应性鼻炎患者铁谱的变化。患者和方法:本研究对30例变应性鼻炎患者进行研究。所有参与者均接受临床评估和以下调查:全血图像,血清铁蛋白,血清铁和总铁结合能力(TIBC)和IgE。采用视觉模拟评分法(VAS)评价变应性鼻炎的严重程度。结果:研究患者中男性18例(60%),女性12例(40%),平均年龄11.3±4.2 (SD)岁,平均发病年龄4.6±3.01(SD)岁,平均病程6.7±2.9年。本组患者中有8例(26.7%)有阳性家族史。重度变应性鼻炎患儿缺铁及缺铁性贫血的发生率明显高于轻度变应性鼻炎患儿。轻、中、重度变应性鼻炎患者Hb、MCH、HCT、铁蛋白、血清铁、TIBC差异均有统计学意义(p值= 0.037)。轻、中、重度患者IgE差异有统计学意义(p值= 0.015)。血清IgE与儿童变应性鼻炎的严重程度相关。结论:儿童变应性鼻炎患者缺铁性贫血的患病率高于非特应性鼻炎患者。缺铁性贫血随着变应性鼻炎的严重程度而显著增加。血清IgE与儿童变应性鼻炎的严重程度相关。
{"title":"The incidence of Iron Deficiency Anemia in Allergic Rhinitis patients in Qena University Hospital","authors":"U. Taya, A. Abdelraheem, Reham Farouk Sayed, A. Selim, Mahmoud Khalefa","doi":"10.21608/svuijm.2023.195475.1535","DOIUrl":"https://doi.org/10.21608/svuijm.2023.195475.1535","url":null,"abstract":"Background: Allergic rhinitis is a common disease of immune origin. It affects the quality of life of patients negatively. Objectives: To evaluate the changes in iron profile in allergic rhinitis patients. Patients and methods : This study was conducted on thirty patients with allergic rhinitis. All of the participants were subjected to clinical evaluation and the following investigations: Complete blood picture, Serum ferritin, Serum iron and total iron binding capacity (TIBC) and IgE. Visual analogue scale (VAS) score was used to measure the severity of allergic rhinitis. Results : Among the studied patients, there were 18 males (60%) and 12 females (40%), the mean age of studied patients was 11.3 ± 4.2 (SD) years with mean onset age of 4.6 ± 3.01(SD) years and mean duration of disease of 6.7 ± 2.9 years. There were 8 patients (26.7%) with positive family history in the studied patients. The incidence of iron deficiency and iron deficiency anemia was significantly higher in children with severe allergic rhinitis compared with mild cases. Also we found statistically significant difference (p-value = 0.037) between mild, moderate & severe cases of allergic rhinitis as regard Hb, MCH, HCT, ferritin, serum iron and TIBC. A statistically significant difference (p-value = 0.015) was noted between mild, moderate & severe cases as regard IgE. Serum IgE is correlated with the severity of allergic rhinitis in children. Conclusion : Prevalence of iron deficiency anemia in pediatric patients with allergic rhinitis is higher than in patients without atopic disease. Iron deficiency anemia increases markedly with severity of allergic rhinitis. Serum IgE is correlated with the severity of allergic rhinitis in children.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78594397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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SVU International Journal of Medical Sciences
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