Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752073
T. M. Nassef, Reham M. Fliefel, M. Marei, N. Solouma, Y. Kadah
In this paper, a new approach for computing different anatomical regions in dental Computed Tomography (CT) is presented. The approach consists of two steps. First, a HU threshold window sets to separate between different regions upon their gray-level values; second, a set of objects are generated and texture descriptors are calculated for selected windows from the image data sample. Finally, identification of different anatomical regions set for mandible bones to determine the cystic lesion volume based on numerical methods. Preliminary results obtained for dental CT of female patient aged 14 years old complaining of bilateral swelling in her mandible are presented.
{"title":"Computer assisted determination of mandibular cystic lesion volume from computed tomographic data","authors":"T. M. Nassef, Reham M. Fliefel, M. Marei, N. Solouma, Y. Kadah","doi":"10.1109/MECBME.2011.5752073","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752073","url":null,"abstract":"In this paper, a new approach for computing different anatomical regions in dental Computed Tomography (CT) is presented. The approach consists of two steps. First, a HU threshold window sets to separate between different regions upon their gray-level values; second, a set of objects are generated and texture descriptors are calculated for selected windows from the image data sample. Finally, identification of different anatomical regions set for mandible bones to determine the cystic lesion volume based on numerical methods. Preliminary results obtained for dental CT of female patient aged 14 years old complaining of bilateral swelling in her mandible are presented.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127107543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano-sized polymeric drug carriers have played promising part for improving the therapeutic effect of drug by providing the drug, properties to enact in a sustained and long circulating manner. Iron oxide (IOs) nanoparticles on the other hand are useful in biomedicine for T2-weigheted magnetic resonance imaging (MRI), to visualize fine details using MRI especially the reticulo-endothelial system (RES), the place where they accumulate the most after administration. The idea of this work is to combine the sustained and long circulating property of the polymeric nanoparticles on the functionality of the IOs, so as to provide long circulating MRI contrast agent. We have used PLGA (a co-polymer of lactic acid and glycolic acid) as a model polymer, D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as surfactant and hydrophobic IOs synthesized by thermal decomposition. Encapsulation of IOs in the polymer matrix was done using a modified nanoprecipitation method, the difference in chemistry between the drug and the IOs was exploited, and parameter optimization was done, the IOs distribution in the polymeric matrix was observed to vary with the method of choice i.e. single emulsion method or nanoprecipitation method. The synthesized IOs PLGA/TPGS hybrid nanoparticles were tested invivo using xenograft mice for their ability to target tumour through enhanced permeability and retention (EPR).
{"title":"Superparamagnetic iron oxides formulated in polylactide-co-glycolide/ D-alpha-tocopherol polyethylene glycol 1000 succinate (PLGA/TPGS) nanoparticles for high contrast MRI","authors":"Chandrasekharan Prashant, Maity Dipak, Yong Cai Xian, Chuang Kai-Hsiang, Ding Jun, Fengtong Shen","doi":"10.1109/MECBME.2011.5752145","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752145","url":null,"abstract":"Nano-sized polymeric drug carriers have played promising part for improving the therapeutic effect of drug by providing the drug, properties to enact in a sustained and long circulating manner. Iron oxide (IOs) nanoparticles on the other hand are useful in biomedicine for T2-weigheted magnetic resonance imaging (MRI), to visualize fine details using MRI especially the reticulo-endothelial system (RES), the place where they accumulate the most after administration. The idea of this work is to combine the sustained and long circulating property of the polymeric nanoparticles on the functionality of the IOs, so as to provide long circulating MRI contrast agent. We have used PLGA (a co-polymer of lactic acid and glycolic acid) as a model polymer, D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as surfactant and hydrophobic IOs synthesized by thermal decomposition. Encapsulation of IOs in the polymer matrix was done using a modified nanoprecipitation method, the difference in chemistry between the drug and the IOs was exploited, and parameter optimization was done, the IOs distribution in the polymeric matrix was observed to vary with the method of choice i.e. single emulsion method or nanoprecipitation method. The synthesized IOs PLGA/TPGS hybrid nanoparticles were tested invivo using xenograft mice for their ability to target tumour through enhanced permeability and retention (EPR).","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"37 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125929527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752078
M. Vakilzadeh, M. Asghari, H. Salarieh, M. Parnianpour
A central problem in motor control is to understand how the many biomechanical degrees of freedom are coordinated to achieve a goal. A common assumption is that Central Nervous System (CNS) will plan tasks based on open-loop optimal control theory which simultaneously predicts state variables and motor commands based on a compound objective function. A 3D computational method incorporated with 18 anatomically oriented muscles is used to simulate human trunk system. Direct collocation method allows us to convert a constrained optimal control problem to a common nonlinear programming problem to assume the spinal stability condition. Trunk movement from the upright standing to 60 degrees of flexion is simulated based on this method. Incorporation of the stability condition with the open-loop optimal controller resulted in an increase of antagonistic activities which would increase the joint stiffness around the Lumbosacral joint in response to gravity perturbation. Results showed that different patterns of trunk movement and back muscles activity can be explained based on change in the coefficient of two performance indices.
{"title":"A computation tool to simulate trunk motion and predict muscle activation by assigning different weights to physical and physiological criteria","authors":"M. Vakilzadeh, M. Asghari, H. Salarieh, M. Parnianpour","doi":"10.1109/MECBME.2011.5752078","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752078","url":null,"abstract":"A central problem in motor control is to understand how the many biomechanical degrees of freedom are coordinated to achieve a goal. A common assumption is that Central Nervous System (CNS) will plan tasks based on open-loop optimal control theory which simultaneously predicts state variables and motor commands based on a compound objective function. A 3D computational method incorporated with 18 anatomically oriented muscles is used to simulate human trunk system. Direct collocation method allows us to convert a constrained optimal control problem to a common nonlinear programming problem to assume the spinal stability condition. Trunk movement from the upright standing to 60 degrees of flexion is simulated based on this method. Incorporation of the stability condition with the open-loop optimal controller resulted in an increase of antagonistic activities which would increase the joint stiffness around the Lumbosacral joint in response to gravity perturbation. Results showed that different patterns of trunk movement and back muscles activity can be explained based on change in the coefficient of two performance indices.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115077487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Gester, C. Gabler, K. V. von Trotha, N. Butz, U. Neumann, T. Schmitz-Rode, U. Steinseifer
Some of the major complications leading to high morbidity and mortality rates in intestine surgery are caused by anastomotic insufficiencies. As the suture represents a crucial factor for the successful treatment of intestine anastomosis, it is of critical importance to investigate the tearing of sutured tissue. The goal of this study consists in examining the tear-out characteristics of stitched porcine small intestinal tissue as a function of the position of the stitch, using an optical strain measurement system. Furthermore, the hole formation of two different suture materials (monofilament and braided) with a single stitch is examined and compared. A clear trend for strain characteristic cannot be found for all number of stitches. In the case of four stitches however, it can be observed that for four out of six samples the outer stitches show a higher strain distribution than the inner ones. The comparison of the hole formation indicates that tissue stitched with monofilament PDS II tears by exhibiting a broader deformation pattern than tissue stitched with braided Vicryl.
{"title":"Optical strain measurement and tear-out behavior of sutured porcine small intestine tissue using a standarized procedure","authors":"K. Gester, C. Gabler, K. V. von Trotha, N. Butz, U. Neumann, T. Schmitz-Rode, U. Steinseifer","doi":"10.1166/JMIHI.2011.1030","DOIUrl":"https://doi.org/10.1166/JMIHI.2011.1030","url":null,"abstract":"Some of the major complications leading to high morbidity and mortality rates in intestine surgery are caused by anastomotic insufficiencies. As the suture represents a crucial factor for the successful treatment of intestine anastomosis, it is of critical importance to investigate the tearing of sutured tissue. The goal of this study consists in examining the tear-out characteristics of stitched porcine small intestinal tissue as a function of the position of the stitch, using an optical strain measurement system. Furthermore, the hole formation of two different suture materials (monofilament and braided) with a single stitch is examined and compared. A clear trend for strain characteristic cannot be found for all number of stitches. In the case of four stitches however, it can be observed that for four out of six samples the outer stitches show a higher strain distribution than the inner ones. The comparison of the hole formation indicates that tissue stitched with monofilament PDS II tears by exhibiting a broader deformation pattern than tissue stitched with braided Vicryl.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115090135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanosecond electroporation has a range of applications including gene therapy and treatment of melanoma tumors. On applying a nanosecond high voltage pulse, potential differences are generated across the membranes of the internal organelles resulting in its electroporation. This paper investigates the effect of nanosecond high voltage pulses simulated on a biological cell placed in a conductive medium (water). The effect of cell size, shape (spherical and elliptical) and membrane thickness on electroporation is investigated. Significant difference in the field was observed indicating the importance of these factors in the success of electroporation in the event of application of external nanosecond high voltage electrical pulse.
{"title":"Biological cell electroporation using nanosecond electrical pulses","authors":"O. G. M. Khan, A. El-Hag","doi":"10.1166/JMIHI.2011.1041","DOIUrl":"https://doi.org/10.1166/JMIHI.2011.1041","url":null,"abstract":"Nanosecond electroporation has a range of applications including gene therapy and treatment of melanoma tumors. On applying a nanosecond high voltage pulse, potential differences are generated across the membranes of the internal organelles resulting in its electroporation. This paper investigates the effect of nanosecond high voltage pulses simulated on a biological cell placed in a conductive medium (water). The effect of cell size, shape (spherical and elliptical) and membrane thickness on electroporation is investigated. Significant difference in the field was observed indicating the importance of these factors in the success of electroporation in the event of application of external nanosecond high voltage electrical pulse.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115523857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752159
Katherine Ernest, Christina Lamei, Sarah Mohamed, Mariam Shakshuk, Islam S. Badreldin, I. ElBabli
Patients with heart disease suffer much to have diagnostic ECG sessions especially in rural areas and areas with high population. This is mainly due to the remoteness of distance between patients and the medical units, as well as traffic congestion. Doctors also need a fast and reliable way to be able to check on their patients and provide a diagnosis irrespective of where they are. In this paper we describe the design and implementation of a telecardiology system using ZigBee. Our proposed system will provide doctors with the ability to monitor, and diagnose their patients remotely over the Internet. The system is capable of receiving a serial stream of data and extracting relevant packets from the measurements of the patient's vital signs. The implemented software allows patients to easily connect with their doctors and to send their data via Internet. The ECG signal is monitored in a real-time mode with the ability of keeping records through SCP-ECG (Standard Communication Protocol) standard.
特别是在农村和人口密集地区，心脏病患者诊断心电图的难度较大。这主要是由于病人和医疗单位之间距离遥远，以及交通拥挤。医生还需要一种快速可靠的方法来检查他们的病人，并提供诊断，而不管他们在哪里。本文介绍了一种基于ZigBee的远程心电系统的设计与实现。我们提出的系统将为医生提供通过互联网远程监控和诊断病人的能力。该系统能够接收一系列数据流，并从患者的生命体征测量中提取相关数据包。实现的软件使患者可以轻松地与医生联系，并通过互联网发送数据。采用SCP-ECG (Standard Communication Protocol)标准对心电信号进行实时监控，并具有记录功能。
{"title":"A ZigBee-based telecardiology system for remote healthcare service delivery","authors":"Katherine Ernest, Christina Lamei, Sarah Mohamed, Mariam Shakshuk, Islam S. Badreldin, I. ElBabli","doi":"10.1109/MECBME.2011.5752159","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752159","url":null,"abstract":"Patients with heart disease suffer much to have diagnostic ECG sessions especially in rural areas and areas with high population. This is mainly due to the remoteness of distance between patients and the medical units, as well as traffic congestion. Doctors also need a fast and reliable way to be able to check on their patients and provide a diagnosis irrespective of where they are. In this paper we describe the design and implementation of a telecardiology system using ZigBee. Our proposed system will provide doctors with the ability to monitor, and diagnose their patients remotely over the Internet. The system is capable of receiving a serial stream of data and extracting relevant packets from the measurements of the patient's vital signs. The implemented software allows patients to easily connect with their doctors and to send their data via Internet. The ECG signal is monitored in a real-time mode with the ability of keeping records through SCP-ECG (Standard Communication Protocol) standard.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115987242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752106
L. Fraiwan, Mohammed Awwad, Ma'en Mahdawi, S. Jamous
Patients with defects in their limbs use prosthetic devices that require a great mental and physical effort during early stages of training where many patients gave up the use of these prosthetics due to the difficulties during training. This work presents a start point for training patient on using prosthetic devices using virtual reality prosthesis. The proposed system consists mainly of an electromyography (EMG) system connected to the patient arm (biceps and triceps muscles) and interfaced with a PC using a data acquisition system. The PC uses Matlab to enhance the EMG signals and detect the presence of events in them. These events are used to control a virtual hand with two movements; grasping and wrist rotation. The system was tested on a subject who performed the grasping and wrist rotation for 90 trials. The overall success rate was found to be 84%.
{"title":"Real time virtual prosthetic hand controlled using EMG signals","authors":"L. Fraiwan, Mohammed Awwad, Ma'en Mahdawi, S. Jamous","doi":"10.1109/MECBME.2011.5752106","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752106","url":null,"abstract":"Patients with defects in their limbs use prosthetic devices that require a great mental and physical effort during early stages of training where many patients gave up the use of these prosthetics due to the difficulties during training. This work presents a start point for training patient on using prosthetic devices using virtual reality prosthesis. The proposed system consists mainly of an electromyography (EMG) system connected to the patient arm (biceps and triceps muscles) and interfaced with a PC using a data acquisition system. The PC uses Matlab to enhance the EMG signals and detect the presence of events in them. These events are used to control a virtual hand with two movements; grasping and wrist rotation. The system was tested on a subject who performed the grasping and wrist rotation for 90 trials. The overall success rate was found to be 84%.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"24 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120873381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752090
Majida Al Shamsi, M. Al-Qutayri, J. Jeedella
This paper presents the architecture as well as the implementation of a system that helps blind person navigate independently within an enclosed environment such as the home. The system uses a wireless mesh network to provide the first level localization. It also incorporates additional components to provide more refined location and orientation information. Optimal path planning is done by a server that communicates wirelessly with the portable mobile unit that can be pushed by the blind person. The blind person issues commands and receives direction responses using audio signals.
{"title":"Blind assistant navigation system","authors":"Majida Al Shamsi, M. Al-Qutayri, J. Jeedella","doi":"10.1109/MECBME.2011.5752090","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752090","url":null,"abstract":"This paper presents the architecture as well as the implementation of a system that helps blind person navigate independently within an enclosed environment such as the home. The system uses a wireless mesh network to provide the first level localization. It also incorporates additional components to provide more refined location and orientation information. Optimal path planning is done by a server that communicates wirelessly with the portable mobile unit that can be pushed by the blind person. The blind person issues commands and receives direction responses using audio signals.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"338 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114815282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752129
O. Al-Bataineh, K. Lweesy, L. Fraiwan
Noninvasive transdermal delivery of insulin is suggested in this paper using ultrasound transducers to improve the quality of life of diabetic patients. It is a preferable technique over the traditional invasive and painful subcutaneous insulin injections. Ten piston-shaped ultrasound transducers operating in the mid frequency range (100–200 kHz) were housed to include a reservoir that intended to hold insulin during in vivo transdermal delivery. Eleven rabbits were divided into two groups. The control group (n=6) did not receive ultrasound while the exposure group (n=5) received ultrasound for only ten minutes. Over the recording period of 60 minutes, blood Glucose levels in the control group remained around 125 mg/dl; while for the exposure group, it reduced from 132.4 mg/dl at the beginning of the experiment to 87.6 mg/dl after 60 minutes. Piston transducers in the mid range frequency were found feasible in transdermal insulin delivery in vivo using local rabbits. More investigations are required to test more frequency ranges with different hyperglycemic rabbit models.
{"title":"Noninvasive transdermal insulin delivery using ultrasound transducers","authors":"O. Al-Bataineh, K. Lweesy, L. Fraiwan","doi":"10.1109/MECBME.2011.5752129","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752129","url":null,"abstract":"Noninvasive transdermal delivery of insulin is suggested in this paper using ultrasound transducers to improve the quality of life of diabetic patients. It is a preferable technique over the traditional invasive and painful subcutaneous insulin injections. Ten piston-shaped ultrasound transducers operating in the mid frequency range (100–200 kHz) were housed to include a reservoir that intended to hold insulin during in vivo transdermal delivery. Eleven rabbits were divided into two groups. The control group (n=6) did not receive ultrasound while the exposure group (n=5) received ultrasound for only ten minutes. Over the recording period of 60 minutes, blood Glucose levels in the control group remained around 125 mg/dl; while for the exposure group, it reduced from 132.4 mg/dl at the beginning of the experiment to 87.6 mg/dl after 60 minutes. Piston transducers in the mid range frequency were found feasible in transdermal insulin delivery in vivo using local rabbits. More investigations are required to test more frequency ranges with different hyperglycemic rabbit models.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127881883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-04-19DOI: 10.1109/MECBME.2011.5752089
A. Nahvi, F. Bahrami
In this paper, we investigated effects of deep brain stimulation (DBS) on Parkinson's disease (PD) when different target sites in the basal ganglia are stimulated. The targets which are investigated are subthalamic nucleus (STN), globus pallidus interna (GPi), and globus pallidus externa (GPe). For this purpose we used a computational model of the basal ganglia-thalamocortical system (BGTCS) with parameters calculated for mean field. This model is able to reproduce both the normal and parkinsonian activities of basal ganglia, thalamus and cortex in a unified structure. Our results suggest that DBS in the STN and GPe could restore the thalamus relay activity, while DBS in the GPi could inhibit it. Our results are compatible with the experimental and the clinical outcomes about the effects of DBS of different targets.
{"title":"Investigating the effect of different targets in deep brain stimulation on symptoms of Parkinson's disease using a mean-field model of the basal ganglia-thalamocortical system","authors":"A. Nahvi, F. Bahrami","doi":"10.1109/MECBME.2011.5752089","DOIUrl":"https://doi.org/10.1109/MECBME.2011.5752089","url":null,"abstract":"In this paper, we investigated effects of deep brain stimulation (DBS) on Parkinson's disease (PD) when different target sites in the basal ganglia are stimulated. The targets which are investigated are subthalamic nucleus (STN), globus pallidus interna (GPi), and globus pallidus externa (GPe). For this purpose we used a computational model of the basal ganglia-thalamocortical system (BGTCS) with parameters calculated for mean field. This model is able to reproduce both the normal and parkinsonian activities of basal ganglia, thalamus and cortex in a unified structure. Our results suggest that DBS in the STN and GPe could restore the thalamus relay activity, while DBS in the GPi could inhibit it. Our results are compatible with the experimental and the clinical outcomes about the effects of DBS of different targets.","PeriodicalId":348448,"journal":{"name":"2011 1st Middle East Conference on Biomedical Engineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126497648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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