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Invasive blood pressure curves simulation device 有创血压曲线模拟装置
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752098
J. Kijonka, M. Penhaker, J. Cernohorský
Patient monitor modules have various inputs for vital function measurement. We can practice many of these measurements with some students in the laboratory of biomedical engineering. However, invasive blood pressure (IBP) measurement demonstration is impossible. This paper is dealing with design and realization of a programmable invasive blood pressure simulator. This device is able to generate programmable behavior of voltage signal with correspond to blood pressure curve. The user communication interface of the device allows choosing the type of generated signal by LCD and 4 push buttons. The wide spectrums of generated signals, which correspond to physiological or pathological blood pressure curves, are stored in a user programmable memory. The output connectors of the device can be directly connected to a patient monitor IBP module input. Invasive blood pressure measurement simulation for educational purposes and calibrating the patients monitors are the general usages of the developed device.
病人监护模块有各种输入的重要功能测量。我们可以在生物医学工程实验室和一些学生一起练习这些测量方法。然而,有创血压(IBP)测量演示是不可能的。本文研究了一种可编程侵入式血压模拟器的设计与实现。该装置能够生成与血压曲线相对应的电压信号的可编程行为。设备的用户通信界面可通过LCD和4个按钮选择产生的信号类型。产生的宽频谱信号,与生理或病理血压曲线相对应,存储在用户可编程存储器中。该设备的输出连接器可以直接连接到患者监护IBP模块输入。有创血压测量模拟教学目的和校准患者监护仪是该设备的一般用途。
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引用次数: 2
Classification of human vs. non-human, and subtyping of human influenza viral strains using Profile Hidden Markov Models 利用隐马尔可夫模型对人类与非人类流感病毒株进行分类和分型
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752105
F. F. Sherif, Y. Kadah, M. El-Hefnawi
Influenza is one of the most important emerging and reemerging infectious diseases, causing high morbidity and mortality in communities (epidemic) and worldwide (pandemic). Here, Classification of human vs. non-human influenza, and subtyping of human influenza viral strains virus is done based on Profile Hidden Markov Models. The classical ways of determining influenza viral subtypes depend mainly on antigenic assays, which is time-consuming and not fully accurate. The introduced technique is much cheaper and faster, yet usually can still yield high accuracy. Multiple sequence alignments were done for all human HA subtypes (H1, H2, H3 and H5), and NA subtypes (N1 and N2), followed by profile-HMMs models generation, calibration and evaluation using the HMMER suite for each group. Subtyping accuracy of all HA and NA models achieved 100%, while host classification (human vs. non-human) has accuracies varied between (55.5% and 97.5%) according to HA subtype.
流感是最重要的新发和再发传染病之一,在社区(流行病)和全球(大流行)造成高发病率和死亡率。在这里,人类与非人类流感的分类,以及人类流感病毒株病毒的亚型是基于Profile隐马尔可夫模型进行的。确定流感病毒亚型的经典方法主要依赖抗原测定,这既耗时又不完全准确。所介绍的技术更便宜,更快,但通常仍然可以产生很高的准确性。对所有人类HA亚型(H1, H2, H3和H5)和NA亚型(N1和N2)进行多个序列比对,然后使用HMMER套件对每个组进行profile- hmm模型生成,校准和评估。所有HA和NA模型的亚型分型准确率均达到100%,而宿主分类(人类与非人类)的准确率根据HA亚型在55.5%至97.5%之间。
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引用次数: 2
Estimation of the skin-air interface in mammograms using level sets 用水平集估计乳房x线照片中皮肤-空气界面
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752110
Gregoris Liasis, S. Petroudi
A method for the estimation of the breast contour in mammograms is presented. Segmentation of the breast region from the background is made difficult due to the fact that the compressed breast edge is mostly composed of adipose tissue that is radiolucent. The algorithm presented uses level sets to establish the corresponding skin-air boundary. An initial preprocessing procedure is performed where the image contrast is improved and the breast edge is enhanced. Artifacts, labels and noise are also removed from the mammogram. Following the breast boundary is identified using the level set formulation, by Chan and Vese, and the results are quantitatively evaluated against the radiologist's ground truth.
提出了一种乳房轮廓估计方法。由于压缩的乳房边缘主要由放射性的脂肪组织组成,因此从背景中分割乳房区域变得困难。该算法使用水平集来建立相应的皮肤-空气边界。执行初始预处理程序,其中图像对比度得到改善,乳房边缘得到增强。伪影、标签和噪声也从乳房x光片中去除。以下乳房边界是由Chan和Vese使用水平集公式确定的,并根据放射科医生的基本事实对结果进行定量评估。
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引用次数: 2
Detection and processing of full channel ionic current through indigenized Patch Clamp Technique 国产膜片钳技术对全通道离子电流的检测与处理
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752147
M. Hassan, N. Bushra, I. Haq, F. Ahmed
The importance of Noble prize winning “Patch Clamp Technique” is well documented. However, Patch Clamp Technique is very expensive and hence hinders research in developing countries. In this paper detection, processing and recording of ultra low current from induced cells by using transimpedence amplifier is described. The sensitivity of the proposed amplifier is in the range of femto amperes (fA). Capacitive-feedback is used with active load to obtain a 20MΩ transimpedance gain. The challenging task in designing includes achieving adequate performance in gain, noise immunity and stability. The circuit designed by the authors was able to measure current in the range of 300 fA to 100 pA. Adequate performance shown by the amplifier with different input current and outcome result was found to be within the acceptable error range. Results were recorded using LabView 8.5® for further research.
诺贝尔奖获奖“膜片钳技术”的重要性是有口可言的。然而,膜片钳技术非常昂贵,因此阻碍了发展中国家的研究。本文介绍了利用跨接放大器对诱导细胞产生的超低电流进行检测、处理和记录。所提出放大器的灵敏度在飞通安培(fA)的范围内。电容反馈与有源负载一起使用,可获得20MΩ跨阻增益。设计中具有挑战性的任务包括在增益、抗噪性和稳定性方面取得足够的性能。作者设计的电路能够测量300 fA到100 pA范围内的电流。在不同的输入电流和输出结果下,放大器的性能都在可接受的误差范围内。使用LabView 8.5®记录结果,以便进一步研究。
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引用次数: 1
Artificial organs design: Towards the integration of disciplines 人工器官设计:走向学科整合
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752096
G. Catapano
In this paper, the evolution of design methods is briefly analyzed and discussed with reference to artificial organs intended to substitute for metabolic bodily functions. In the last seventy years, the methods of artificial organ design have evolved towards a more systematic approach that more and more accounts for biological issues (man-machine interfaces, biocompatibility issues, etc.) to the point that at the forefront of research the design paradigm is shifting from fully synthetic mechanical/electronic prostheses towards the development in vitro of tissue engineered replacement organs/tissues, where the artificial part is fully integrated with the biological counterpart. To keep up with this complex scenario, design methods have shifted: from an experiments-based to the methodical approach; from one to multiple objective functions; from focusing on one single process to multiple concurring processes, often differing in time and space scale; from seeking solutions consisting of one device to many coupled devices; from seeking a generic solution for all patients' needs to seeking personalized solutions for each patient, so that the patient should not adapt to an existing device or implant, but it is the device or implant that has to adapt to the patients' specific needs and circumstances. The impact of this evolution in design on the way courses in biomedical engineering are organized and taught in Europe is also briefly analyzed and discussed.
本文就人体代谢性功能的人造器官的设计方法的演变作一简要的分析和讨论。在过去的七十年里,人工器官设计的方法已经发展到一个更加系统化的方法,越来越多地考虑到生物问题(人机界面,生物相容性问题等),以至于在研究的前沿,设计范式正在从完全合成的机械/电子假体转向体外组织工程替代器官/组织的发展。人工部分与生物部分完全结合。为了跟上这种复杂的情况,设计方法已经发生了转变:从基于实验的方法到系统的方法;从一个目标函数到多个目标函数;从关注单一进程到多个并发进程,往往在时间和空间尺度上有所不同;从寻求由一个器件组成的解决方案到寻求多个耦合器件;从寻求针对所有患者需求的通用解决方案到为每个患者寻求个性化解决方案,这样患者就不应该适应现有的设备或植入物,而是设备或植入物必须适应患者的特定需求和情况。设计的这种演变对欧洲生物医学工程课程的组织和教学方式的影响也进行了简要的分析和讨论。
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引用次数: 2
Personalised mechatronic valve time-schedule optimiser for hydrocephalus shunt 脑积水分流的个性化机电阀门时间表优化器
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752140
N. Al-Zubi, W. Al-Nuaimy, Mohammad Al-Hadidi
Hydrocephalus is an excessive accumulation of the cerebrospinal fluid (CSF) in the ventricles of the brain, without treatment it leads in brain damage. The usual treatment is a shunt procedure implanted into the ventricles of the brain to drain the excess fluid to another part of the body. Current shunts are controlled by a pressure dependent valve, while recent developed shunts are utilising mechatronic valves. Compared to the current differential pressure valves, mechatronic valves are regulated by time-based schedule rather than differential pressure across the valve. Therefore, it is important that this time schedule is chosen properly for each patient so that a normal ICP is preserved. Choosing proper time schedule for each patient is still one of the challenges facing the implementation of such valves. This work presents a new method to propose optimal valve time-schedule using an ICP dynamics model and patient's ICP traces, so that shunt valves can be configured accordingly. This method presents a precise and efficient way of how the ICP model can be utilised in evaluating the patient's ICP traces and hence proposing a personalised optimal valve time-schedule as a function of mean measured ICP for each individual patient that can keep the ICP within the normal levels.
脑积水是脑脊液(CSF)在脑室的过度积聚,如果不进行治疗,就会导致脑损伤。通常的治疗方法是在脑室植入分流术,将多余的液体排出到身体的另一部分。电流分流由压力相关阀控制,而最近开发的分流使用机电阀。与目前的差压阀相比,机电阀是通过基于时间的调度来调节的,而不是通过阀上的压差。因此,为每位患者选择合适的时间安排以保留正常的ICP是很重要的。为每位患者选择合适的时间安排仍然是实施此类瓣膜所面临的挑战之一。本文提出了一种利用ICP动力学模型和患者的ICP轨迹来提出最佳瓣膜时间表的新方法,从而可以相应地配置分流阀。该方法提供了一种精确而有效的方法,如何利用ICP模型来评估患者的ICP轨迹,从而提出个性化的最佳瓣膜时间表,作为每个患者平均测量ICP的函数,可以将ICP保持在正常水平。
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引用次数: 1
Multidisciplinary teamwork training for progress in developing and using medical technology 多学科团队合作培训,促进医学技术的发展和应用
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752118
V. Rogalewicz, G. J. Verkerke, R. Reilly, G. Catapano
A characteristic feature of biomedical engineering is multidisciplinarity. Engineers from different branches have to work together with life sciences experts. Their working culture is different: they speak different languages, think different ways, and if they say the same, usually they have something entirely different in mind. Moreover, the world is shrinking and people experience working in a multicultural environment. However, working in a multicultural team brings problems and conflicts. There are barriers to communication. The problem is that students are generally not aware of all these differences. This ignorance often frustrates cooperation and makes it difficult, limiting the possible benefits. Considering this a serious problem, European Society of Engineering and Medicine organizes a summer school “Biomedical Engineering Teamwork” to give students an opportunity to work in multidisciplinary multicultural teams, and teach them to exchange ideas and benefit from different approaches.
生物医学工程的一个特点是多学科性。来自不同部门的工程师必须与生命科学专家一起工作。他们的工作文化是不同的:他们说不同的语言,思考不同的方式,如果他们说同样的话,通常他们的想法是完全不同的。此外,世界正在缩小,人们在一个多元文化的环境中工作。然而,在一个多元文化的团队中工作也会带来问题和冲突。沟通有障碍。问题是学生们通常没有意识到所有这些差异。这种无知常常使合作受挫,使合作变得困难,限制了可能的好处。考虑到这是一个严重的问题,欧洲工程与医学学会组织了一个暑期学校“生物医学工程团队”,让学生有机会在多学科多元文化的团队中工作,并教会他们交流思想,从不同的方法中受益。
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引用次数: 2
Noise reduction of echocardiography images using Isomap algorithm 基于Isomap算法的超声心动图降噪研究
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752087
P. Gifani, H. Behnam, Ahmad Shalbaf, Z. Sani
Medical applications of ultrasound imaging have expanded enormously over the last two decades. De-noising is challenging issues for better medical interpretation and diagnosis on high volume of data sets in echocardiography. In this paper, manifold learning algorithm is applied on 2-D echocardiography images to discover the relationship between the frames of consecutive cycles of the heart motion. By this approach, each image is depicted by a point on reconstructed two-dimensional manifold by Isomap algorithm and similar points related to similar images according to the property of periodic heartbeat cycle stand together. Noise reduction is achieved by averaging similar images on reconstructed manifold. By comparing the proposed method with some common methods and according to qualitative expert's opinions, the proposed method has maximum noise reduction, minimum blurring and better contrast among the similar methods.
在过去的二十年里,超声成像的医学应用得到了极大的扩展。在超声心动图中,为了更好地对大量数据集进行医学解释和诊断,降噪是一个具有挑战性的问题。本文将流形学习算法应用于二维超声心动图图像,以发现心脏运动连续周期帧之间的关系。该方法利用Isomap算法在重构的二维流形上用一个点来描述图像,并根据心跳周期的性质将相似图像相关的相似点放在一起。通过对重构流形上的相似图像进行平均来实现降噪。通过与一些常用方法的比较,并根据定性专家的意见,该方法在同类方法中降噪最大,模糊最小,对比度更好。
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引用次数: 4
Methods for ECG signal compression with reconstruction via cubic spline approximation 基于三次样条近似重构的心电信号压缩方法
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752122
Olga Malgina, E. Plesnik, A. Košir, J. Milenkovic, M. Zajc, J. Tasic
In this article, two algorithms are described that are suited for real-time biomedical signal compression. These being, Amplitude Threshold compression and SQ segment compression. Comparison of these methods with well known methods such as lossy Discrete Cosine Transform (DCT) and lossless Turning Point (TP) is shown. The compression method outputs were reconstructed using a cubic spline approximation and compared. The values of compression ratio (CR), percent mean square difference (PRD) and area criteria were chosen for method comparison. Here it is shown that the method presented here (Threshold, SQ segment) provide considerably lower CR values than the DCT method and slightly higher CR values than the TP method. However, the PRD value for both proposed methods is lower than the PRD values of reference methods DCT and TP.
本文介绍了两种适合于实时生物医学信号压缩的算法。它们分别是振幅阈值压缩和SQ段压缩。将这些方法与已知的有损离散余弦变换(DCT)和无损拐点变换(TP)等方法进行了比较。采用三次样条近似重构压缩法输出,并进行了比较。选择压缩比(CR)、均方差百分比(PRD)和面积标准值进行方法比较。这里显示,这里提出的方法(阈值,SQ段)提供显著低于DCT方法的CR值,略高于TP方法的CR值。然而,两种方法的PRD值均低于参考方法DCT和TP的PRD值。
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引用次数: 4
Force control of laparoscopy grasper using antagonistic shape memory alloy 拮抗形状记忆合金在腹腔镜握把力控制中的应用
Pub Date : 2011-04-19 DOI: 10.1109/MECBME.2011.5752134
Soheil Kianzad, A. Amini, Soheil O. Karkouti
Using special tools at the end-effectors of Minimally Invasive Surgery (MIS) robots has an important role in building a simple and well controlled system that increases dexterity of surgeons. Having local, lightweight and powerful actuators at end-effectors could help to simplified wrist design and saving the number of degrees-of-freedom (DOFs). Shape Memory Alloy (SMA) actuators considered as good candidates and presented significant behaviors in producing the force needed for gripping. In order to have force and tactile information of gripper, local sensors are needed to give force feedback which helps to have control over wire tension and prevent exceeding force causing tissue damages. In this paper a novel design of forceps that uses antagonistic SMA actuators is presented. This configuration helps to increase force and speed and eliminates bias spring used in similar works. Moreover, this antagonistic design makes it possible to provide sensors needed for force control and place them at the back part of the forceps instead of attaching them to jaws which will result in a smaller forceps design. To control the exerted force, a force control method is also presented using the feedback obtained through the sensors. This enhanced design seems to address some of the existing shortcomings of similar models and remove them effectively.
在微创手术(MIS)机器人末端执行器上使用特殊工具,对于建立一个简单、控制良好的系统,提高外科医生的灵活性具有重要作用。末端执行器具有局部、轻量和强大的致动器,有助于简化腕部设计并节省自由度(dof)。形状记忆合金(SMA)驱动器被认为是良好的候选者,并且在产生夹持所需的力方面表现出显著的行为。为了获得夹持器的力和触觉信息,需要局部传感器提供力反馈,帮助控制导线张力,防止过大的力造成组织损伤。本文提出了一种新型的使用拮抗SMA致动器的镊子设计。这种结构有助于增加力和速度,并消除类似工程中使用的偏置弹簧。此外,这种对抗性设计使得提供力控制所需的传感器成为可能,并将它们放置在钳的后部,而不是将它们连接到钳口,这将导致更小的钳设计。为了控制所施加的力,提出了一种利用传感器反馈进行力控制的方法。这种增强的设计似乎解决了类似模型的一些现有缺点,并有效地消除了它们。
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引用次数: 14
期刊
2011 1st Middle East Conference on Biomedical Engineering
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