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The synthetic-biology challenges for biosecurity: examples from iGEM 生物安全的合成生物学挑战:来自iGEM的例子
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1866884
P. Millett, Christopher R Isaac, Irina Rais, P. Rutten
ABSTRACT Although synthetic biology and biological engineering are often portrayed as emerging disciplines, there is over a decade of experience in their interactions with biosecurity. The International Genetically Engineered Machine competition (iGEM) brings together nearly 6000 students on multidisciplinary teams to engineer biology following synthetic biology’s “design, build, test, and learn” cycle. During its fifteen-year existence, iGEM has been affected by biosecurity and in turn has affected it. This article describes four specific case studies at iGEM, highlighting their implications for biosecurity, and proposes ways to improve relevant biosecurity procedures and practices. It showcases how embracing engineering approaches and principles can help to structure efforts to strengthen biosecurity.
虽然合成生物学和生物工程经常被描述为新兴学科,但它们与生物安全的相互作用已有十多年的经验。国际基因工程机器竞赛(iGEM)汇集了近6000名学生组成多学科团队,按照合成生物学的“设计、构建、测试和学习”周期来设计生物学。在其存在的15年中,iGEM受到生物安全的影响,反过来也影响了它。本文描述了iGEM的四个具体案例研究,强调了它们对生物安全的影响,并提出了改进相关生物安全程序和实践的方法。它展示了采用工程方法和原则如何有助于构建加强生物安全的努力。
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引用次数: 2
Verification and implementation of the Biological and Toxin Weapons Convention 核查和执行《生物和毒素武器公约》
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1823102
S. Drobysz
ABSTRACT This article looks at verification and implementation as two aspects of the 1972 Biological and Toxin Weapons Convention (BWC) that Ray Zilinskas had identified as weaknesses. Based on his predictions and suggestions to develop a comprehensive and effective verification regime, the first part of this article offers some reflections on the status and prospects of BWC verification. It provides a brief overview of persisting controversies surrounding aspects Zilinskas discussed, and considers the effectiveness of the BWC despite the absence of verification, including verification “alternatives” that Zilinskas had also anticipated. The second part of this article focuses on the national legislative implementation of the BWC. This topic has received less attention in Zilinskas’s publications but remains an important component of the BWC regime, with expanding obligations to adopt laws and regulations relating to biological weapons, yet persisting gaps in national legal regimes.
摘要本文将核查和执行视为1972年《生物及毒素武器公约》的两个方面,Ray Zilinskas认为这两个方面存在不足。基于他对建立一个全面有效的核查制度的预测和建议,本文第一部分对《生物武器公约》核查的现状和前景进行了一些思考。它简要概述了围绕Zilinskas讨论的各方面持续存在的争议,并考虑了尽管没有核查,但《生物武器公约》的有效性,包括Zilinska预期的核查“替代方案”。本文的第二部分侧重于《生物武器公约》的国家立法执行情况。这一主题在Zilinskas的出版物中受到的关注较少,但仍然是《生物武器公约》制度的一个重要组成部分,通过与生物武器有关的法律和法规的义务不断扩大,但国家法律制度仍存在差距。
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引用次数: 2
Monitoring and verification in the biological-weapons area 生物武器领域的监测与核查
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1865629
G. Kraatz-Wadsack
ABSTRACT This article provides a brief overview of the ongoing monitoring and verification (OMV) regime in Iraq in the biological-weapons area. As an integral part of the formal ceasefire arrangement in 1991, the United Nations Security Council established an international verification regime encompassing nuclear, biological, and chemical weapons and some ballistic missiles. The verification regime was built on two mutually supportive pillars. One pillar related to disarmament validation, i.e., verifying that all prohibited weapons, facilities, and related items and certain ballistic missiles in Iraq were destroyed or rendered harmless, and all past weapons-of-mass-destruction (WMD) activities had ceased. The second pillar was ongoing monitoring to continuously verify that non-proscribed activities were not being diverted to reconstitute WMD programs. Biological-weapons disarmament and OMV in Iraq provide an example of an effective system that may serve as a reference point for future efforts.
本文简要介绍了伊拉克生物武器领域的不断监测与核查(OMV)制度。作为1991年正式停火安排的一个组成部分,联合国安全理事会建立了一个包括核武器、生物武器和化学武器以及一些弹道导弹在内的国际核查制度。核查制度建立在两个相互支持的支柱上。一个支柱与裁军核查有关,即核查伊拉克境内所有被禁止的武器、设施和有关项目以及某些弹道导弹是否已被销毁或变为无害,以及过去所有大规模毁灭性武器活动是否已停止。第二个支柱是持续监测,以不断核查未受禁止的活动没有被转用于重建大规模杀伤性武器项目。伊拉克的生物武器裁军和OMV提供了一个有效制度的例子,可以作为今后努力的参考点。
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引用次数: 2
Biodefense and the return to great-power competition 生物防御与大国竞争的回归
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1852751
G. Epstein
ABSTRACT The 2017 US National Security Strategy asserts that, “after being dismissed as a phenomenon of an earlier century, great power competition returned,” pointing to actions that Russia and China have taken to reassert their influence and attempt to change the international order. Such a shift has implications for biodefense. It suggests an increased likelihood of the development and potential use of biological weapons by states, which had been downplayed by those who have been more concerned about non-state biological-weapons programs. State program access to expertise, facilities, and resources implies a greater level of technological sophistication than would typically be credited to non-state actors, influencing the requirements for national biodefense programs to detect, characterize, respond, to, and attribute a biological attack. States also could have missions for biological weapons that differ from those intended by terrorists.
摘要《2017年美国国家安全战略》声称,“在被视为上个世纪的一种现象后,大国竞争又回来了”,指出俄罗斯和中国为重申其影响力并试图改变国际秩序而采取的行动。这种转变对生物防御有影响。这表明,各国开发和潜在使用生物武器的可能性增加,而那些更关心非国家生物武器计划的人却淡化了这一点。国家项目获得专业知识、设施和资源意味着比通常认为的非国家行为者更先进的技术水平,影响了国家生物防御项目检测、表征、应对和归因生物攻击的要求。各国也可能有不同于恐怖分子意图的生物武器任务。
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引用次数: 0
Wrestling with imponderables: assessing perceptions of biological-weapons utility 与不可估量的因素搏斗:评估人们对生物武器效用的看法
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1858621
Glenn Cross
Understanding states’ perception of biological-weapons (BW) utility is key to understanding the motivations behind states’ development, possession, and use of these weapons. The calculations underlying a determination of utility are complex, having to balance threat perceptions, national scientific and industrial capacities, diplomatic relations, and the importance of prohibitory norms. Case studies of the former US and British offensive BW programs, beginning in World War II, illustrate how perceptions of BW utility evolve under wartime circumstances. The US case also illustrates how perceptions of BW utility heightened during periods of international tension, namely the Korean War and early in the John F. Kennedy administration. Both the US and UK examples also demonstrate how possession of nuclear weapons affected perceptions of BW utility and the role of BW in military doctrine. Given the prohibitions on BW development and possession, BW utility today is limited to small-scale, covert operations, including assassinations, much like the recent assassinations and attempted assassinations conducted by North Korea and Russia. Unlike chemical weapons, BW have the additional characteristics of delaying the onset of effects, mimicking natural diseases, and foiling attribution efforts.
了解各国对生物武器效用的看法是了解各国开发、拥有和使用这些武器背后动机的关键。确定效用的计算是复杂的,必须平衡威胁感知、国家科学和工业能力、外交关系以及禁止规范的重要性。从第二次世界大战开始,对前美国和英国进攻性生物武器项目的案例研究表明,在战时情况下,人们对生物武器效用的看法是如何演变的。美国的案例也说明了在国际紧张时期,即朝鲜战争和约翰·F·肯尼迪政府早期,人们对BW效用的看法是如何增强的。美国和英国的例子也表明,拥有核武器如何影响对生物武器效用的看法以及生物武器在军事学说中的作用。鉴于禁止发展和拥有生物武器,如今生物武器的使用仅限于小规模的秘密行动,包括暗杀,就像朝鲜和俄罗斯最近进行的暗杀和未遂暗杀一样。与化学武器不同,生物武器具有延迟效应发生、模仿自然疾病和挫败归因努力的额外特征。
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引用次数: 1
Dual-use biology: building trust and managing perceptions of intent 两用生物学:建立信任和管理意图感知
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1853910
Filippa Lentzos
ABSTRACT At a time of heightened concern about potential future biological-weapons threats, this article considers how the international community can use the Biological and Toxin Weapons Convention framework to strengthen compliance monitoring of rapidly increasing dual-use capacities around the globe. It presents three conceptual layers within the treaty regime which states can draw from to inform their compliance judgments: one legally binding, one politically binding, and one wholly voluntary. The article outlines how these were established and how they have been used so far, and argues for an incremental, inclusive, practical, and forward-looking approach to evolving these structures to better manage perceptions of the intent behind dual-use capacities, and to further trust between states.
在人们对未来潜在的生物武器威胁高度关注之际,本文探讨了国际社会如何利用《生物与毒素武器公约》框架,加强对全球迅速增长的军民两用能力的遵守监测。它在条约制度中提出了三个概念层,各国可以从中吸取并为其合规判断提供信息:一个具有法律约束力,一个具有政治约束力,一个完全自愿。本文概述了这些机制是如何建立的以及迄今为止是如何使用的,并提出了一种渐进的、包容的、实用的和前瞻性的方法来发展这些结构,以更好地管理对双重用途能力背后意图的看法,并进一步增进国家之间的信任。
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引用次数: 0
Sitting on the boundary: the role of reports in investigations into alleged biological-weapons use 坐在边界上:报告在调查指称使用生物武器方面的作用
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1872968
C. McLeish, Joshua R. Moon
ABSTRACT Concerns that biological weapons will be used has focused attention on the need to develop a capability to independently investigate any allegation of use. The United Nations Secretary-General’s Mechanism is one such tool, and efforts to revitalize and strengthen it have acknowledged a wide range of technical difficulties to overcome. This article emphasizes another aspect of the investigatory process: communicating the findings of an investigation. The article frames the investigation report as more than a technical recounting of what the investigators did and found, regarding it instead as the means by which the policy-making audience “makes sense” of the allegation. Drawing on literatures associated with science policy and “boundary objects,” the article reflects on the guidance provided thus far and suggests there has been an implicit move toward seeing the reports as “boundary documents.” The suggestion made here is that this implicit recognition should be now made explicit so that the critical position of the report is better appreciated. This has implications for the training of rostered experts.
摘要对生物武器将被使用的担忧集中在发展独立调查任何使用指控的能力的必要性上。联合国秘书长机制就是这样一个工具,振兴和加强该机制的努力已经认识到需要克服一系列广泛的技术困难。本文强调了调查过程的另一个方面:传达调查结果。文章认为,调查报告不仅仅是对调查人员所做和发现的技术性叙述,而是将其视为决策受众“理解”指控的手段。这篇文章借鉴了与科学政策和“边界对象”相关的文献,反思了迄今为止提供的指导,并表明已经有一种将报告视为“边界文件”的隐含趋势。这里提出的建议是,现在应该明确这种隐含的认识,以便更好地理解报告的关键地位。这对列入名册的专家的培训有影响。
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引用次数: 2
Perspectives on “bioterrorism” in the nineteenth century: the philosophy of mass destruction, fake news, and other fictions 对19世纪“生物恐怖主义”的透视:大规模杀伤、假新闻和其他小说的哲学
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1843252
W. Carus
ABSTRACT The concept of “biological terrorism” predates the provenance of the term. Prominent anarchist intellectuals as well as sensationalist journalists alike promulgated the concept of deliberate disease during the last half of the nineteenth century. However, their published works do not reflect an accurate understanding of the biological sciences. In fact, the most accurate writings on disease as a weapon came not from anarchists or journalists, but from science-fiction writers.
摘要“生物恐怖主义”的概念早于该术语的起源。19世纪下半叶,著名的无政府主义知识分子和耸人听闻的记者都提出了蓄意疾病的概念。然而,他们发表的作品并没有反映出对生物科学的准确理解。事实上,关于疾病作为武器的最准确的著作不是来自无政府主义者或记者,而是来自科幻作家。
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引用次数: 0
“Science was digging its own grave”: the Women’s International League for Peace and Freedom and the campaign against chemical and biological warfare “科学在自掘坟墓”:国际妇女和平与自由联盟和反对化学和生物战的运动
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1838703
B. Balmer
The Women’s International League for Peace and Freedom (WILPF) is the oldest active women’s peace organization in the world. Although their overall aim is the abolition of all war, from the outset they voiced particular opposition to chemical warfare. Later, this became a call against both chemical and biological warfare (CBW). This article draws on archival documents to trace this history, concentrating on the early days of WILPF and then on revived interest in the topic during the late 1960s and early 1970s. While early WILPF did not define CBW as an issue with any special gendered relevance for women, the historical record shows WILPF placed emphasis on its leading role in organizing opposition. It also shows a consistency of approach, WILPF often acting in an educational capacity as an informer of public opinion about the horrors of CBW. Over time, WILPF’s role changed in that the leaders of the key campaigns against CBW came to regard their role as distinct from those of scientists.
国际妇女争取和平与自由联盟是世界上历史最悠久的活跃妇女和平组织。尽管他们的总体目标是废除一切战争,但从一开始他们就特别反对化学战。后来,这成为了对化学战和生物战的呼吁。本文利用档案文件追溯了这段历史,重点讲述了WILPF的早期,然后在20世纪60年代末和70年代初重新引起了人们对这一主题的兴趣。虽然早期的WILPF并没有将CBW定义为一个与女性有任何特殊性别相关性的问题,但历史记录表明,WILPF强调其在组织反对派方面的领导作用。它还表明了方法的一致性,WILPF经常以教育身份充当CBW恐怖事件的舆论告密者。随着时间的推移,WILPF的角色发生了变化,反对CBW的关键运动的领导人开始认为他们的角色与科学家的角色不同。
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引用次数: 1
Developments in systems biology: implications for health and biochemical security 系统生物学的发展:对健康和生化安全的影响
Q2 Social Sciences Pub Date : 2020-09-01 DOI: 10.1080/10736700.2020.1865632
K. Nixdorff
Biological processes occur within complex, vital physiological systems. Systems biology seeks to understand how physiological systems function as a whole, integrating information about interactions in a biological system through computer-assisted modeling, aiming to identify relationships not found within individual biological units. Coupled with advances in the life sciences and computing power, this research is yielding an enormous amount of information about specific targets of vital physiological processes, and enabling predictions about how these targets may respond to a disturbance or change in signaling. This information can be greatly beneficial in treating complex diseases. It also has extended the spectrum of potential threat agents to include bioregulators, which to a great extent regulate the functioning of the nervous, endocrine, and immune systems. There is potential for misuse of the knowledge gained from these studies, and improved methods of targeted delivery of biochemicals make them more feasible weapons agents. Moreover, biochemical security concerns in systems biology are embedded within the larger domain of cyberbiosecurity. There remains a need for proactive approaches to the formulation of biochemical-security-oversight policy that would encompass developments at this interface of the life sciences and information technology.
生物过程发生在复杂的、重要的生理系统中。系统生物学旨在了解生理系统如何作为一个整体运作,通过计算机辅助建模整合生物系统中相互作用的信息,旨在识别在单个生物单位中未发现的关系。再加上生命科学和计算能力的进步,这项研究正在产生关于重要生理过程的特定目标的大量信息,并使人们能够预测这些目标如何对信号的干扰或变化作出反应。这一信息对治疗复杂疾病非常有益。它还扩大了潜在威胁因子的范围,包括生物调节剂,这些调节剂在很大程度上调节神经、内分泌和免疫系统的功能。从这些研究中获得的知识有可能被滥用,而有针对性地运送生化物质的方法得到改进,使它们成为更可行的武器制剂。此外,系统生物学中的生化安全问题嵌入在更大的网络生物安全领域。仍然需要采取积极主动的方法来制定生化安全监督政策,该政策将包括生命科学和信息技术这一领域的发展。
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引用次数: 1
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Nonproliferation Review
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