Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-43
A. Masharipova, G. Derbissalina, D. Zhunussova, G. Nagashybek, D. Amangeldiyeva
Background. Service design is the activity of planning and implementing changes in medical organizations to improve the quality of medical services. In Europe and the USA, service design is widespread in many large multidisciplinary medical centers. Study design. This article is a description of the experience. Methods. The authors described their own experience of using service design in the field of nursing in a private medical center in Astana. Results. The team from the Astana Medical University chose the topic: “increasing the level of satisfaction of patients with chronic diseases with the quality of nursing care in the organization of primary health care.” We used ready-made tools, reflecting their ideas on paper, flipcharts, posters and stickers. Direct data collection (interviewing and observation) by our team was carried out within one month. The planned number of patients and nurses was 10 people each. The interview focused on the subjective experience of the interviewed patients and nurses, revealing their beliefs, attitudes, level of trust and quality of communication with each other. Then the facilitators collected the completed forms and summed up the results. Thus, the focus of attention was shifted towards the low level of communication skills of nurses, taking into account the repeated complaints of patients about the lack of information about upcoming manipulations (tests, operations, diet, etc.), diseases in general, methods of self-care; lack of empathy and medical ethics. The new goal was aimed at increasing patient satisfaction with the communication skills of polyclinic nurses. To solve this problem, it was decided to conduct a two-hour express training among the nurses of the polyclinic to improve the communication skills of nurses by implementing the NURSE protocol. Conclusions. Service design has been applied for the first time in the healthcare industry of Kazakhstan as an innovative tool for improving patient-centered nursing care.
{"title":"Experience in using the service design in the development of nursing services in the republic of Kazakhstan","authors":"A. Masharipova, G. Derbissalina, D. Zhunussova, G. Nagashybek, D. Amangeldiyeva","doi":"10.56936/18290825-2022.16.3-43","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-43","url":null,"abstract":"Background. Service design is the activity of planning and implementing changes in medical organizations to improve the quality of medical services. In Europe and the USA, service design is widespread in many large multidisciplinary medical centers. \u0000Study design. This article is a description of the experience.\u0000Methods. The authors described their own experience of using service design in the field of nursing in a private medical center in Astana.\u0000Results. The team from the Astana Medical University chose the topic: “increasing the level of satisfaction of patients with chronic diseases with the quality of nursing care in the organization of primary health care.” We used ready-made tools, reflecting their ideas on paper, flipcharts, posters and stickers. Direct data collection (interviewing and observation) by our team was carried out within one month. The planned number of patients and nurses was 10 people each. The interview focused on the subjective experience of the interviewed patients and nurses, revealing their beliefs, attitudes, level of trust and quality of communication with each other. Then the facilitators collected the completed forms and summed up the results. Thus, the focus of attention was shifted towards the low level of communication skills of nurses, taking into account the repeated complaints of patients about the lack of information about upcoming manipulations (tests, operations, diet, etc.), diseases in general, methods of self-care; lack of empathy and medical ethics. The new goal was aimed at increasing patient satisfaction with the communication skills of polyclinic nurses. To solve this problem, it was decided to conduct a two-hour express training among the nurses of the polyclinic to improve the communication skills of nurses by implementing the NURSE protocol. \u0000Conclusions. Service design has been applied for the first time in the healthcare industry of Kazakhstan as an innovative tool for improving patient-centered nursing care.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133299010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-65
B. Baimakhanov, A. Chormanov, I. Madadov, E. Belgibaev, E.S. Nabiev, Zh.M. Syrymov, B.G. Rgebaev, N. Saduakas, I. Sagatov
Report of our clinical case of laparoscopic hand-assisted donor heminephrectomy in living donor with horseshoe kidney (Horseshoe kidne) has a good innovation in donor kidney retrieval technique and particularly in case of congenital anomalies. Kidney transplantation is a “gold standard” of treatment of chronic kidney disease in terminal stage. Nowadays there is a strong deficit of donor organs. Due to undeveloped cadaveric kidney transplantation we always try to accept donors with different anatomic particularities. In our practice we perform traditionally laparoscopic hand-assisted donor nephrectomy either in case of single artery and vein or multiple vessels. This case is a report of kidney transplantation from 65 –years old woman for her 39-years old son with end-stage renal disease (ESRD). Technical challenge was due to that donor had a Horseshoe kidne with parenchymal isthmus, with 4 arteries on right half and 2 arteries on the left with retrocaval position of the latters. We performed literature review for similar cases and found out that usually open laparotomy was performed in this patients. So we decided not to change the familiar for us technique in this case also. Donor underwent laparoscopic hand-assisted donor heminephrectomy with subsequent successful implantation of graft and immediate function.
{"title":"Laparoscopic hand-assisted donor heminephrectomy in living donor with horseshoe kidney. Case study","authors":"B. Baimakhanov, A. Chormanov, I. Madadov, E. Belgibaev, E.S. Nabiev, Zh.M. Syrymov, B.G. Rgebaev, N. Saduakas, I. Sagatov","doi":"10.56936/18290825-2022.16.3-65","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-65","url":null,"abstract":"Report of our clinical case of laparoscopic hand-assisted donor heminephrectomy in living donor with horseshoe kidney (Horseshoe kidne) has a good innovation in donor kidney retrieval technique and particularly in case of congenital anomalies.\u0000Kidney transplantation is a “gold standard” of treatment of chronic kidney disease in terminal stage. Nowadays there is a strong deficit of donor organs. Due to undeveloped cadaveric kidney transplantation we always try to accept donors with different anatomic particularities. In our practice we perform traditionally laparoscopic hand-assisted donor nephrectomy either in case of single artery and vein or multiple vessels.\u0000This case is a report of kidney transplantation from 65 –years old woman for her 39-years old son with end-stage renal disease (ESRD). Technical challenge was due to that donor had a Horseshoe kidne with parenchymal isthmus, with 4 arteries on right half and 2 arteries on the left with retrocaval position of the latters.\u0000We performed literature review for similar cases and found out that usually open laparotomy was performed in this patients. So we decided not to change the familiar for us technique in this case also. Donor underwent laparoscopic hand-assisted donor heminephrectomy with subsequent successful implantation of graft and immediate function.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"19 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128544511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-100
A. Barseghyan, L. Nazaryan, Simonyan
Pharmacists have an important role within the healthcare system. They can offer some services to the patients including consultation, patient education and therapeutic management. Community pharmacists can assess the type and severity of pain, monitor treatment and guide medication regulation to improve the treatment of the pain. The involvement of pharmacists in nonprescription medication counseling about pain will increase the public’s ability to understand the risks and benefits of over-the-counter drugs. Aim and objects was to study and analyze professional abilities and role of pharmacy employees during the pain management. The survey was conducted among 285 employees of licensed pharmacies in Armenia with the help of questionnaires, the number of which was determined according to “The Survey System Version 11.0”. Survey data were entered and analyzed using SPSS software package. The study was quantitative investigation and the questionnaire was developed based on the World Health Organization standard questionnaire. As a result of our research, it became clear that pharmacists have pure, indistinct knowledge about adverse reactions of over-the-counter analgesics and pharmacy employees in the Republic of Armenia have incomplete knowledge and ideas about pain management. According to the study pharmacists’ information sources was not reliable and the use of these sources in professional pharmaceutical practice were not inappropriate. Involvement of pharmacists in primary care pain management is very important and pain management training of pharmacy staffs should be encouraged. Pharmacist should be a part of a multidisciplinary pain management team and for this reason comprehensive information on pain management as well as development of practical skills should be included in continuing education programs for pharmacists.
{"title":"Evaluation of pharmacist interventions as part of a multidisciplinary pain management team","authors":"A. Barseghyan, L. Nazaryan, Simonyan","doi":"10.56936/18290825-2022.16.3-100","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-100","url":null,"abstract":"Pharmacists have an important role within the healthcare system. They can offer some services to the patients including consultation, patient education and therapeutic management. Community pharmacists can assess the type and severity of pain, monitor treatment and guide medication regulation to improve the treatment of the pain. The involvement of pharmacists in nonprescription medication counseling about pain will increase the public’s ability to understand the risks and benefits of over-the-counter drugs.\u0000Aim and objects was to study and analyze professional abilities and role of pharmacy employees during the pain management. The survey was conducted among 285 employees of licensed pharmacies in Armenia with the help of questionnaires, the number of which was determined according to “The Survey System Version 11.0”. Survey data were entered and analyzed using SPSS software package. The study was quantitative investigation and the questionnaire was developed based on the World Health Organization standard questionnaire. As a result of our research, it became clear that pharmacists have pure, indistinct knowledge about adverse reactions of over-the-counter analgesics and pharmacy employees in the Republic of Armenia have incomplete knowledge and ideas about pain management. According to the study pharmacists’ information sources was not reliable and the use of these sources in professional pharmaceutical practice were not inappropriate. Involvement of pharmacists in primary care pain management is very important and pain management training of pharmacy staffs should be encouraged.\u0000Pharmacist should be a part of a multidisciplinary pain management team and for this reason comprehensive information on pain management as well as development of practical skills should be included in continuing education programs for pharmacists.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125848143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-25
M. P. Wardhana, D. Tumangger, H. J. Juwono, E. Ernawati, S. Rifdah, I. A. Wafa, K. Kuntaman, E. G. Dachlan
Objectives: to assess the effect-related inflammatory and coagulation biomarkers in pregnancy and their connection with the coronavirus disease of 2019 (COVID-19). Methods: A prospective case-control study was carried out among normal third-trimester pregnant women admitted to the labor room of Dr. Soetomo General Academic Hospital between January until June 2021. Two classified groups of patients were established in accordance with the result of the RT-PCR test. Demographic, clinical and laboratory results data of the two groups were collected and compared. Results: Platelet-to-lymphocyte ratio (PLR) was shown to be the only significant biomarkers found in the expectant with COVID-19, which was 35.8% higher compared to the ones free of COVID-19 [212.25 (157.57-269.37) vs 156.29 (128.55-195.3), p=0.048]. Logistic regression analysis of PLR between groups showed that the level of PLR was an independent factor in pregnant women with COVID-19 (OR 4.483, 95%CI 1.262-15.926). The ROC analysis showed that the PLR cut-off among the expectant was 171.335, with both sensitivity and specificity were 66.7% (p=0.021). The result shows no significant differences in leukocyte count, absolute neutrophils – lymphocyte count and percentage, neutrophil-to-lymphocyte ratio (NLR) and D-Dimer level between pregnant women infected with COVID-19 and free of the virus (p>0.05). Conclusion: Intriguingly, physiological adaptation during the course of the third trimester of pregnancy found no difference in most inflammation and coagulation markers, both in the condition of infected COVID-19 or not. The evidence from this single-centre study supports the viewpoint that elevated PLR was associated with independent biomarkers and thereby might be helpful to detect expectant with COVID-19.
{"title":"The explorat ion of inflammat ory and coagulation biomarkers between pregnantwomen with andwithout COVID-19","authors":"M. P. Wardhana, D. Tumangger, H. J. Juwono, E. Ernawati, S. Rifdah, I. A. Wafa, K. Kuntaman, E. G. Dachlan","doi":"10.56936/18290825-2022.16.2-25","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-25","url":null,"abstract":"Objectives: to assess the effect-related inflammatory and coagulation biomarkers in pregnancy and their connection with the coronavirus disease of 2019 (COVID-19). Methods: A prospective case-control study was carried out among normal third-trimester pregnant women admitted to the labor room of Dr. Soetomo General Academic Hospital between January until June 2021. Two classified groups of patients were established in accordance with the result of the RT-PCR test. Demographic, clinical and laboratory results data of the two groups were collected and compared. Results: Platelet-to-lymphocyte ratio (PLR) was shown to be the only significant biomarkers found in the expectant with COVID-19, which was 35.8% higher compared to the ones free of COVID-19 [212.25 (157.57-269.37) vs 156.29 (128.55-195.3), p=0.048]. Logistic regression analysis of PLR between groups showed that the level of PLR was an independent factor in pregnant women with COVID-19 (OR 4.483, 95%CI 1.262-15.926). The ROC analysis showed that the PLR cut-off among the expectant was 171.335, with both sensitivity and specificity were 66.7% (p=0.021). The result shows no significant differences in leukocyte count, absolute neutrophils – lymphocyte count and percentage, neutrophil-to-lymphocyte ratio (NLR) and D-Dimer level between pregnant women infected with COVID-19 and free of the virus (p>0.05). Conclusion: Intriguingly, physiological adaptation during the course of the third trimester of pregnancy found no difference in most inflammation and coagulation markers, both in the condition of infected COVID-19 or not. The evidence from this single-centre study supports the viewpoint that elevated PLR was associated with independent biomarkers and thereby might be helpful to detect expectant with COVID-19.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"292 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117333446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-58
O. Kryuchkova, I. Klyaritskaya, E. Itskova, E. V. Maksimova, E.Yu. Turna, Y. Lutai, E. A. Kostyukova
In patients who have undergone coronavirus infection, decompensation of the course of chronic cardiovascular diseases, including arterial hypertension, is often observed, which is due to a number of their common pathogenetic mechanisms. To evaluate the comparative effectiveness of controlling arterial hypertension and improving the quality of life who underwent a new coronavirus infection. Totally 62 patients with arterial hypertension who had previously undergone coronavirus infection were examined. The criterion for inclusion in the study was a decrease in blood pressure control on the background of previously effective two-component therapy. Depending on the heart rate at rest, the patients were divided into two groups. In both groups, triple antihypertensive therapy was used as a second step. In the first group - a combination of perindopril 5 mg, indapamide 2.5 mg, amlodipine 5 mg. The second group included patients with a heart rate of more than 80 beats per minute, perindopril 5 mg, bisoprolol 5 mg, amlodipine 5 mg. The antihypertensive efficacy of the studied drug combinations was analyzed according to the data of 24-hour blood pressure monitoring. During the treatment of arterial hypertension, the dynamics of quality-of-life indicators was analyzed. A study of 24-hour monitoring and blood pressure variability in both groups of patients with coronavirus infection demonstrated the lack of effective blood pressure control. The use of the analyzed variants of three-component therapy made it possible to achieve the target level of blood pressure in 89.6% and 93.9% of cases, respectively. In both study groups, the achievement of office blood pressure control was accompanied by a statistically significant decrease in all its daily parameters. On the background of antihypertensive therapy in both groups of the study, there was a significant and reliable (p<0.05) increase in all parameters for assessing the quality of life, which reflects the effectiveness of the treatment of arterial hypertension in patients who have had a coronavirus infection in increasing satisfaction with their lives and improving social functioning. Therapy with the use of perindopril, bisoprolol, amlodipine was accompanied by the achievement of significantly (p<0.05) higher rates of mental and physical health components.
{"title":"Evaluation of the comparative efficacy of the control of arterial hypertension and improvement of the quality of life of patients with arterial hypertension after coronavirus infection using various regimens of three-component antihypertensive therapy","authors":"O. Kryuchkova, I. Klyaritskaya, E. Itskova, E. V. Maksimova, E.Yu. Turna, Y. Lutai, E. A. Kostyukova","doi":"10.56936/18290825-2022.16.3-58","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-58","url":null,"abstract":"In patients who have undergone coronavirus infection, decompensation of the course of chronic cardiovascular diseases, including arterial hypertension, is often observed, which is due to a number of their common pathogenetic mechanisms.\u0000To evaluate the comparative effectiveness of controlling arterial hypertension and improving the quality of life who underwent a new coronavirus infection.\u0000Totally 62 patients with arterial hypertension who had previously undergone coronavirus infection were examined. The criterion for inclusion in the study was a decrease in blood pressure control on the background of previously effective two-component therapy. Depending on the heart rate at rest, the patients were divided into two groups. In both groups, triple antihypertensive therapy was used as a second step. In the first group - a combination of perindopril 5 mg, indapamide 2.5 mg, amlodipine 5 mg. The second group included patients with a heart rate of more than 80 beats per minute, perindopril 5 mg, bisoprolol 5 mg, amlodipine 5 mg. The antihypertensive efficacy of the studied drug combinations was analyzed according to the data of 24-hour blood pressure monitoring. During the treatment of arterial hypertension, the dynamics of quality-of-life indicators was analyzed.\u0000A study of 24-hour monitoring and blood pressure variability in both groups of patients with coronavirus infection demonstrated the lack of effective blood pressure control. The use of the analyzed variants of three-component therapy made it possible to achieve the target level of blood pressure in 89.6% and 93.9% of cases, respectively. In both study groups, the achievement of office blood pressure control was accompanied by a statistically significant decrease in all its daily parameters.\u0000On the background of antihypertensive therapy in both groups of the study, there was a significant and reliable (p<0.05) increase in all parameters for assessing the quality of life, which reflects the effectiveness of the treatment of arterial hypertension in patients who have had a coronavirus infection in increasing satisfaction with their lives and improving social functioning.\u0000Therapy with the use of perindopril, bisoprolol, amlodipine was accompanied by the achievement of significantly (p<0.05) higher rates of mental and physical health components.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127770157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-111
S. Alarsan, N.. Fa'ous, N. Alkhateeb
Objective: Palliative care is a defined medical specialty, and it is focused on helping patients and families who are facing serious illness achieve the best possible quality of life. Despite the extensive literature available about palliative care, it still has imprecise due to its involvement in different specialties and disciplines of healthcare. Therefore, it is crucial to clarify what is meant by palliative care and defines its defining attributes, antecedents and consequences. Method: This study adopted Walker and Avant’s concept analysis approach for analyzing palliative care concept. A thorough literature search was performed in PubMed, CINAHL and Embase databases during the period (1970-2021). A total of 17 articles were reviewed and used to achieve the study objective. Result: After reviewing the screened articles, the study formulated a definition of palliative care as the meaningful and intentional holistic care of patients suffering from terminal illnesses caused by acknowledging and minimize symptoms that would deter the patients’ quality of life while achieving patient dignity by utilizing compassion and support. The study revealed that the defining attributes of palliative care include Holistic, compassion, support, individualized, realistic care. Conclusion: Palliative care was identified as holistic, compassion, supportive and individualized realistic care provided for patients suffering serious illness in order to achieve the desired level of quality of life.
{"title":"Palliative Care: A Concept Analysis","authors":"S. Alarsan, N.. Fa'ous, N. Alkhateeb","doi":"10.56936/18290825-2022.16.2-111","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-111","url":null,"abstract":"Objective: Palliative care is a defined medical specialty, and it is focused on helping patients and families who are facing serious illness achieve the best possible quality of life. Despite the extensive literature available about palliative care, it still has imprecise due to its involvement in different specialties and disciplines of healthcare. Therefore, it is crucial to clarify what is meant by palliative care and defines its defining attributes, antecedents and consequences. Method: This study adopted Walker and Avant’s concept analysis approach for analyzing palliative care concept. A thorough literature search was performed in PubMed, CINAHL and Embase databases during the period (1970-2021). A total of 17 articles were reviewed and used to achieve the study objective. Result: After reviewing the screened articles, the study formulated a definition of palliative care as the meaningful and intentional holistic care of patients suffering from terminal illnesses caused by acknowledging and minimize symptoms that would deter the patients’ quality of life while achieving patient dignity by utilizing compassion and support. The study revealed that the defining attributes of palliative care include Holistic, compassion, support, individualized, realistic care. Conclusion: Palliative care was identified as holistic, compassion, supportive and individualized realistic care provided for patients suffering serious illness in order to achieve the desired level of quality of life.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127908525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-49
A. P. Mohideen, K. Shamna
Antimicrobial resistance is a global concern threatening the whole world. Antimicrobial resistance pathogens cause more than two million illnesses and nearly 23000 deaths per year in the United States. аntimicrobial resistance is linked to roughly 25,000 fatalities per year in Europe. The economic effects of аntimicrobial resistance are significant, with an estimated $20 billion in extra medical spending in the United States each year. This leads to necessity for development of novel antimicrobial agents from various sources. Ocimum tenuiflorum is a popular plant with several biological properties. The present study focuses on investigating the antibacterial potential of the compounds present in Ocimum tenuiflorum by in silico techniques. Initially, compounds were screened for druglikeness analysis based on Lipinski rule of five (RO5). Molecular docking was performed against bacterial DNA gyrase and ligand interactions on the binding sites of the target protein was examined. PASS prediction for antibacterial activity was determined. From the analysis of 22 compounds, we identified four compounds showing higher binding energies, binding site interaction, druglikeness and PASS property. Thus, the compounds Apigenin, Gardenin B, Isothymusin and Cirsilineol can be used for treatment of multidrug resistance bacterial infections.
{"title":"Potential drugs against multidrug resistant bacteria from ocimum \u0000tenuiflorum: An in silico analysis","authors":"A. P. Mohideen, K. Shamna","doi":"10.56936/18290825-2022.16.3-49","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-49","url":null,"abstract":"Antimicrobial resistance is a global concern threatening the whole world. Antimicrobial resistance pathogens cause more than two million illnesses and nearly 23000 deaths per year in the United States. аntimicrobial resistance is linked to roughly 25,000 fatalities per year in Europe. The economic effects of аntimicrobial resistance are significant, with an estimated $20 billion in extra medical spending in the United States each year. This leads to necessity for development of novel antimicrobial agents from various sources. Ocimum tenuiflorum is a popular plant with several biological properties. The present study focuses on investigating the antibacterial potential of the compounds present in Ocimum tenuiflorum by in silico techniques. Initially, compounds were screened for druglikeness analysis based on Lipinski rule of five (RO5). Molecular docking was performed against bacterial DNA gyrase and ligand interactions on the binding sites of the target protein was examined. PASS prediction for antibacterial activity was determined. From the analysis of 22 compounds, we identified four compounds showing higher binding energies, binding site interaction, druglikeness and PASS property. Thus, the compounds Apigenin, Gardenin B, Isothymusin and Cirsilineol can be used for treatment of multidrug resistance bacterial infections.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121140862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.1-58
A. Kulikova, Z. Khabadze, Yu. A. Generalova, R. F. Mokhamed El-Khala, D. Nazarova, Ya. A. Yollybayev
Currently, antiseptics are used at all stages of surgical treatment. Currently, the search continues for antiseptics that have effective properties in suppressing pathological microflora and as safe as possible in relation to tissues. One of the promising antiseptic solutions is a solution based on polyhexanide. The aim of this work was to study the available reports on the effectiveness of the polyhexanide solution, its safety, and experience of use. To assess the effectiveness of using a polyhexonide solution as an antiseptic, a search was made for publications in the scientific databases “PubMed” and “Google Scholar”. A total of 2026 scientific articles were found during the search. When studying the content of the texts, 31 articles were accepted for consideration, corresponding to the given criteria. Polyhexanide solution is widely used in surgical practice. In wound healing, antiseptic treatment is one of the key steps. The suppression of the reproduction of pathological microflora and the effect on the biofilm is extremely important. When analyzing the publications, different results were noted using the polyhexanide solution. Studies of the effectiveness of the polyhexanide solution are currently being actively pursued. Due to its significant efficacy, safety, and ease of use, polyhexamethylene biguanide is promising for use in surgical practice.
{"title":"Application of polyhexanide as a new highly effective antiseptic composition","authors":"A. Kulikova, Z. Khabadze, Yu. A. Generalova, R. F. Mokhamed El-Khala, D. Nazarova, Ya. A. Yollybayev","doi":"10.56936/18290825-2022.16.1-58","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.1-58","url":null,"abstract":"Currently, antiseptics are used at all stages of surgical treatment. Currently, the search continues for antiseptics that have effective properties in suppressing pathological microflora and as safe as possible in relation to tissues. One of the promising antiseptic solutions is a solution based on polyhexanide. The aim of this work was to study the available reports on the effectiveness of the polyhexanide solution, its safety, and experience of use.\u0000To assess the effectiveness of using a polyhexonide solution as an antiseptic, a search was made for publications in the scientific databases “PubMed” and “Google Scholar”.\u0000A total of 2026 scientific articles were found during the search. When studying the content of the texts, 31 articles were accepted for consideration, corresponding to the given criteria.\u0000Polyhexanide solution is widely used in surgical practice. In wound healing, antiseptic treatment is one of the key steps. The suppression of the reproduction of pathological microflora and the effect on the biofilm is extremely important. When analyzing the publications, different results were noted using the polyhexanide solution.\u0000Studies of the effectiveness of the polyhexanide solution are currently being actively pursued. Due to its significant efficacy, safety, and ease of use, polyhexamethylene biguanide is promising for use in surgical practice.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116508211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.1-43
N. G. Sarkisyan, N. Kataeva, A. Akhmetova, A.R. Kukhareva, N. S. Chumakov, K. A. Khlystova, S. Melikyan
Today, it has been proven that saliva is the main medium through which the new COVID-19 coronavirus infection spreads. Since the oral cavity is the gateway for the SARS-CoV-2 virus, the degree of change in the physicochemical parameters of the saliva of people who have had coronavirus infection compared to people who have not had COVID-19 is of interest. This study involved dental patients of the first and second health groups with a history of chronic generalized periodontitis of moderate degree in the stage of remission. We studied physicochemical parameters of saliva such as pH, surface tension and base buffering capacity. The results of this stage of the study showed saliva acidification, that is a decrease in pH in people who had had a new coronavirus infection compared to the indicators of people from the control group. The average values of the surface tension of saliva in patients of the control group are 30% less than in those who have had COVID-19. This indicates that the saliva of people who have not been sick with the new coronavirus contains more surface-active agents (surfactants). Surfactants provide rinsing and disinfecting functions of saliva, therefore, it can be concluded that these functions are less pronounced in patients who have recovered from COVID-19. The base buffering capacity of the saliva of patients who have had COVID-19 is, on average, 35% higher than that of people from the control group. Thus, the pH and the base buffering capacity are in correlation: the lower the pH value, the higher the acidity of the saliva and the higher the base buffering capacity is. At the second stage of the study, similar physicochemical parameters of patients’ saliva were measured after the application of an oral spray containing a synthetic peptide (ZP2) of the active center of granulocyte-macrophage colony-stimulating factor. This spray was used as an antibacterial therapy for the oral cavity after professional hygiene of patients. In 5 minutes after spray irrigation, an increase in saliva pH was observed in all test subjects within the physiological norm. In patients, regardless of their anamnesis, the surface tension of saliva changed in different ways. In a number of people, it increased, which indicates an increase in the concentration of surfactants in saliva, while in others it decreased, which can be explained by the high rate of penetration of surfactants from saliva through the gums into the blood. After the application of the ZP-2 peptide, the base buffering capacity of saliva decreases or remains unchanged. In patients of the control group, the indicators of the base buffering capacity of saliva change less than in patients who have undergone COVID-19. All the studied physicochemical parameters of saliva in patients who had had uncomplicated COVID-19, three months after receiving two negative results for the SARS-CoV-2 virus, remained within the physiological norm.
{"title":"Physicochemical indicators of dental patient saliva who have undergone an uncomplicated coronavirus infection","authors":"N. G. Sarkisyan, N. Kataeva, A. Akhmetova, A.R. Kukhareva, N. S. Chumakov, K. A. Khlystova, S. Melikyan","doi":"10.56936/18290825-2022.16.1-43","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.1-43","url":null,"abstract":"Today, it has been proven that saliva is the main medium through which the new COVID-19 coronavirus infection spreads. Since the oral cavity is the gateway for the SARS-CoV-2 virus, the degree of change in the physicochemical parameters of the saliva of people who have had coronavirus infection compared to people who have not had COVID-19 is of interest.\u0000This study involved dental patients of the first and second health groups with a history of chronic generalized periodontitis of moderate degree in the stage of remission. We studied physicochemical parameters of saliva such as pH, surface tension and base buffering capacity. The results of this stage of the study showed saliva acidification, that is a decrease in pH in people who had had a new coronavirus infection compared to the indicators of people from the control group. The average values of the surface tension of saliva in patients of the control group are 30% less than in those who have had COVID-19. This indicates that the saliva of people who have not been sick with the new coronavirus contains more surface-active agents (surfactants). Surfactants provide rinsing and disinfecting functions of saliva, therefore, it can be concluded that these functions are less pronounced in patients who have recovered from COVID-19. The base buffering capacity of the saliva of patients who have had COVID-19 is, on average, 35% higher than that of people from the control group. Thus, the pH and the base buffering capacity are in correlation: the lower the pH value, the higher the acidity of the saliva and the higher the base buffering capacity is.\u0000At the second stage of the study, similar physicochemical parameters of patients’ saliva were measured after the application of an oral spray containing a synthetic peptide (ZP2) of the active center of granulocyte-macrophage colony-stimulating factor. This spray was used as an antibacterial therapy for the oral cavity after professional hygiene of patients. In 5 minutes after spray irrigation, an increase in saliva pH was observed in all test subjects within the physiological norm. In patients, regardless of their anamnesis, the surface tension of saliva changed in different ways. In a number of people, it increased, which indicates an increase in the concentration of surfactants in saliva, while in others it decreased, which can be explained by the high rate of penetration of surfactants from saliva through the gums into the blood. After the application of the ZP-2 peptide, the base buffering capacity of saliva decreases or remains unchanged. In patients of the control group, the indicators of the base buffering capacity of saliva change less than in patients who have undergone COVID-19.\u0000All the studied physicochemical parameters of saliva in patients who had had uncomplicated COVID-19, three months after receiving two negative results for the SARS-CoV-2 virus, remained within the physiological norm.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128737303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-38
E. V. Maksimova, I. L. Kliaritskaia, E. Stilidi, E. I. Grigorenko, Y. Moshko
Introduction: The frequency of detection of metabolically associated fatty liver disease in the population of developed countries is becoming a non-infectious pandemic, the growth drivers of which are obesity and diabetes mellitus. Currently, metabolically associated fatty liver disease occupies a firm position in the list of the most common liver diseases all over the world. Chronic liver diseases are accompanied by pronounced pathological changes in the composition of the human microflora, manifested by a deficiency of obligate microorganisms and microbial contamination of the small intestine, which requires a long-term therapeutic correction aimed at normalizing the gut microflora. Objective: to study the impact of the intestinal microbiome disorders on the course and progression of metabolically associated fatty liver disease. Materials and methods. The study included 105 patients with metabolically associated fatty liver disease. The diagnosis of metabolically associated fatty liver disease was exhibited on the basis of proven liver steatosis in combination with one of the following criteria: overweight/obesity, type 2 diabetes/insulin resistance syndrome, signs of metabolic dysregulation. Patients underwent a comprehensive clinical and laboratory study. The stage of liver fibrosis was determined using ultrasound elastography (Fibroscan). The study of the intestinal microbiome was carried out using the method of gas chromatography-mass spectrometry. Results and its discussion. It was found that 68.6% of the cases of metabolically associated fatty liver disease were associated with obesity, 27.6% - with overweight body mass. It was revealed that in most patients there was an increase in ALT level, a violation of lipid metabolism (increased levels of total cholesterol, LDL and triglycerides, as well as a decrease in HDL levels), the development of insulin resistance syndrome. Violation of the of the intestinal microflora was revealed in 71.4% of patients. Patients with impaired intestinal microflora have higher levels of ALT, cholesterol, LDL, triglycerides, HOMA-index and lower levels of HDL, higher stage of fibrosis compared to the group without impaired intestinal microflora. Conclusion. Disruption of the intestinal microflora occurs in the majority of patients with metabolically associated fatty liver disease and has a negative impact on the course (leading to more pronounced lipid metabolism disorders, higher ALT and HOMA index levels), as well as the progression of metabolically associated fatty liver disease (leading to a higher stage of fibrosis).
{"title":"Influence of changes in the intestinal microbiome on the course and progression of metabolically associated fatty liver disease","authors":"E. V. Maksimova, I. L. Kliaritskaia, E. Stilidi, E. I. Grigorenko, Y. Moshko","doi":"10.56936/18290825-2022.16.2-38","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-38","url":null,"abstract":"Introduction: The frequency of detection of metabolically associated fatty liver disease in the population of developed countries is becoming a non-infectious pandemic, the growth drivers of which are obesity and diabetes mellitus. Currently, metabolically associated fatty liver disease occupies a firm position in the list of the most common liver diseases all over the world. Chronic liver diseases are accompanied by pronounced pathological changes in the composition of the human microflora, manifested by a deficiency of obligate microorganisms and microbial contamination of the small intestine, which requires a long-term therapeutic correction aimed at normalizing the gut microflora.\u0000Objective: to study the impact of the intestinal microbiome disorders on the course and progression of metabolically associated fatty liver disease.\u0000Materials and methods. The study included 105 patients with metabolically associated fatty liver disease. The diagnosis of metabolically associated fatty liver disease was exhibited on the basis of proven liver steatosis in combination with one of the following criteria: overweight/obesity, type 2 diabetes/insulin resistance syndrome, signs of metabolic dysregulation. Patients underwent a comprehensive clinical and laboratory study. The stage of liver fibrosis was determined using ultrasound elastography (Fibroscan). The study of the intestinal microbiome was carried out using the method of gas chromatography-mass spectrometry.\u0000Results and its discussion. It was found that 68.6% of the cases of metabolically associated fatty liver disease were associated with obesity, 27.6% - with overweight body mass. It was revealed that in most patients there was an increase in ALT level, a violation of lipid metabolism (increased levels of total cholesterol, LDL and triglycerides, as well as a decrease in HDL levels), the development of insulin resistance syndrome. Violation of the of the intestinal microflora was revealed in 71.4% of patients. Patients with impaired intestinal microflora have higher levels of ALT, cholesterol, LDL, triglycerides, HOMA-index and lower levels of HDL, higher stage of fibrosis compared to the group without impaired intestinal microflora.\u0000Conclusion. Disruption of the intestinal microflora occurs in the majority of patients with metabolically associated fatty liver disease and has a negative impact on the course (leading to more pronounced lipid metabolism disorders, higher ALT and HOMA index levels), as well as the progression of metabolically associated fatty liver disease (leading to a higher stage of fibrosis).","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"397 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115215028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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