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Managing Problematic Usage of the Internet and Related Disorders in an Era of Diagnostic Transition: An Updated Review. 在诊断转型时代管理有问题的互联网使用和相关障碍:最新综述。
Q2 Medicine Pub Date : 2021-07-14 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010061
Bernardo Dell'Osso, Ilaria Di Bernardo, Matteo Vismara, Eleonora Piccoli, Federica Giorgetti, Laura Molteni, Naomi A Fineberg, Calogero Virzì, Henrietta Bowden-Jones, Roberto Truzoli, Caterina Viganò

Introduction: Problematic Usage of the Internet (PUI) refers to a broad and likely heterogeneous group of Internet-related conditions associated with behavioural disturbances and functional impairment.

Methods: Within PUI several conditions have been reported, including Gaming Disorder, Shopping Addiction, Cyberchondria, Gambling Disorder, Cyberpornography Addiction and Cyberbullying. While increasing reports in the field try to define the epidemiologic and clinical boundaries of these conditions, the rapid and continuous evolution of Internet related behaviours as well as their problematic/pathological expressions are often difficult to diagnose, assess, approach with treatment interventions and follow-up.

Results: In addition, some of the PUI-related conditions show characteristics of addiction to the Internet as a preferential tool to engage in specific behaviours, while some others exclusively manifest on the Internet, making it necessary to find distinct assessment and treatment pathways.

Conclusion: The inclusion of Internet Gaming Disorder in Section III by the DSM-5 and the recognition of Gaming Disorder by the ICD-11 opened the way for a systematic clinical investigation of this and other PUI-related conditions, particularly in terms of preventive and therapeutic strategies. The present article is aimed at offering an updated clinical overview on the main expressions of PUI, focussing on the latest acquisitions in this evolving field.

导言:有问题的互联网使用(PUI)是指与行为紊乱和功能障碍相关的一组广泛的、可能是异质性的互联网相关病症:方法:据报道,PUI 中存在多种病症,包括游戏障碍、购物成瘾、网络成瘾、赌博障碍、网络色情成瘾和网络欺凌。虽然该领域越来越多的报告试图界定这些病症的流行病学和临床界限,但与互联网相关的行为及其问题/病理表现的快速和持续演变往往难以诊断、评估、治疗干预和随访:此外,一些与 PUI 相关的病症表现出网络成瘾的特征,将网络作为从事特定行为的首选工具,而另一些病症则仅表现为网络成瘾,因此有必要找到不同的评估和治疗途径:结论:DSM-5 将网络游戏障碍纳入第三部分,ICD-11 承认游戏障碍,这为对网络游戏障碍及其他 PUI 相关病症进行系统的临床研究开辟了道路,尤其是在预防和治疗策略方面。本文旨在提供有关 PUI 主要表现形式的最新临床概述,重点介绍这一不断发展的领域的最新研究成果。
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引用次数: 0
Impacts on and Care of Psychiatric Patients during the Outbreak of COVID-19. 新冠肺炎疫情对精神科患者的影响及护理
Q2 Medicine Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010052
Pavarud Puangsri, Vinn Jinanarong, Apichai Wattanapisit

The outbreak of coronavirus disease (COVID-19) in December 2019 has led to massive lifestyle, economic, and health changes. The COVID-19 pandemic has had broad impacts on psychiatric patients, exacerbating symptoms such as psychosis, depression, and suicidal ideation. Therefore, we aimed to review the psychological impacts of COVID-19 on psychiatric patients and mental healthcare staff and provide practical guidance for medical staff and authorities. The main findings of this review included the impacts of COVID-19 on psychiatric patients and mental health professionals as well as the transformation of mental health care. Greater consideration should be given to the care of patients with psychosis and depression because of their lack of self-care ability, neurocognitive impairment, and impaired immune function. Depressive symptoms can be exacerbated due to several factors, such as economic crises, social isolation, and limited physical activity. Unemployment and financial problems can lead to an increased suicide rate. Consequently, mental healthcare workers' workload can increase, which could lead to burnout and psychological symptoms such as insomnia, depression, and anxiety. A transformation of psychiatric care is needed during the time of the pandemic. While emergency care should be maintained, outpatient care should be limited to decrease viral spread. Shifting care to telemedicine and community-based psychiatry can be helpful. Inpatient services should be adapted by tightening admission criteria, shortening the length of hospital stays, suspending some group activities, limiting visitors, and preparing for quarantine if necessary. Mental healthcare workers can be supported with telecommunication, appropriate work shifts, alternative accommodations, and good communication between the team leader and staff.

2019年12月爆发的冠状病毒病(COVID-19)导致了巨大的生活方式、经济和健康变化。新冠肺炎大流行对精神病患者产生了广泛影响,加剧了精神病、抑郁症和自杀意念等症状。因此,我们旨在回顾COVID-19对精神病患者和精神卫生保健人员的心理影响,为医务人员和当局提供实践指导。本综述的主要发现包括COVID-19对精神病患者和精神卫生专业人员的影响以及精神卫生保健的转变。精神病和抑郁症患者由于缺乏自我照顾能力、神经认知障碍和免疫功能受损,应给予更多的照顾。由于经济危机、社会孤立和体力活动有限等因素,抑郁症状可能会加剧。失业和经济问题会导致自杀率上升。因此,精神保健工作者的工作量可能会增加,这可能导致倦怠和心理症状,如失眠、抑郁和焦虑。在大流行期间,需要转变精神科护理。在维持急诊护理的同时,应限制门诊护理,以减少病毒传播。将护理转移到远程医疗和社区精神病学可能会有所帮助。应调整住院服务,收紧入院标准,缩短住院时间,暂停部分团体活动,限制访客,必要时做好隔离准备。可以通过电信、适当的工作班次、替代住宿以及团队领导和员工之间的良好沟通来支持精神卫生保健工作者。
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引用次数: 19
In Memory of Hagop Akiskal. 纪念Hagop Akiskal。
Q2 Medicine Pub Date : 2021-05-31 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010048
Mauro G Carta, Francesc Colom, Andreas Erfurth, Michele Fornaro, Heinz Grunze, Elie Hantouche, Antonio E Nardi, Antonio Preti, Eduard Vieta, Elie Karam
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy Hospital del Mar, Barcelona, Spain Department of Psychiatry and Psychotherapeutic Medicine, Klinik Hietzing, Vienna, Austria Laboratory of Molecular and Translational Psychiatry, Department of Neuroscience, School of Medicine, University "Federico II", Naples, Italy Center for Psychiatry Weinsberg, Klinikum am Weissenhof, Weinsberg, Germany Center for Anxiety and Mood Disorders, Anxiety & Mood Center, 117, Rue de Rennes, Paris 75006, France Institute of Psychiatry,Federal University of Rio de Janeiro,Rio de Janeiro, Brazil Department of Neurosciences, University of Turin, 10124 Turin, Italy Bipolar Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain Department of Psychiatry and Clinical Psychology, Faculty of Medicine, Balamand University, Beirut, Lebanon
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引用次数: 9
Catatonia Associated with Hyponatremia: Case Report and Brief Review of the Literature. 紧张症伴低钠血症:病例报告及文献综述。
Q2 Medicine Pub Date : 2021-05-24 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010026
Vaios Peritogiannis, Dimitrios V Rizos
Background: Catatonia is a syndrome of altered motor behavior that is mostly associated with general medical, neurologic, mood and schizophrenia-spectrum disorders. The association of newly onset catatonic symptoms with hyponatremia has been rarely reported in the literature. Case Presentation: We present a rare case of a young female patient with schizophrenia, who presented with catatonic symptoms in the context of hyponatremia due to water intoxication. The symptoms were eliminated with the correction of hyponatremia. There are only a few reports of hyponatremia-associated catatonia in psychiatric and non-psychiatric patients. Sometimes, catatonic symptoms may co-occur with newly onset psychotic symptoms and confusion, suggesting delirium. In several cases, the catatonic symptoms responded to specific treatment with benzodiazepines or electroconvulsive therapy. Conclusion: Hyponatremia may induce catatonic symptoms in patients, regardless of underlying mental illness, but this phenomenon is even more relevant in patients with a psychotic or mood disorder, which may itself cause catatonic symptoms. It is important for clinicians not to attribute newly-onset catatonic symptoms to the underlying psychotic or mood disorder without measuring sodium serum levels. The measurement of sodium serum levels may guide treating psychiatrists to refer the patient for further investigation and appropriate treatment.
背景:紧张症是一种运动行为改变的综合征,主要与一般医学、神经、情绪和精神分裂症谱系障碍有关。文献中很少报道新发紧张性症状与低钠血症的关联。病例介绍:我们报告一例罕见的年轻女性精神分裂症患者,她在水中毒引起的低钠血症背景下出现紧张症状。随着低钠血症的纠正,症状消失。在精神病和非精神病患者中,只有少数低钠血症相关的紧张症的报道。有时,紧张性症状可能与新发精神病性症状和精神错乱同时出现,提示谵妄。在一些病例中,紧张性症状对苯二氮卓类药物或电休克治疗的特异性治疗有反应。结论:低钠血症可诱发患者紧张性症状,而与潜在的精神疾病无关,但这种现象与精神病或情绪障碍患者更为相关,而精神病或情绪障碍本身可能引起紧张性症状。对于临床医生来说,在没有测量血清钠水平的情况下,不要将新发作的紧张性症状归因于潜在的精神病或情绪障碍是很重要的。血清钠水平的测量可以指导治疗精神科医生将患者转介给进一步的调查和适当的治疗。
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引用次数: 2
Strategies for Psychiatric Rehabilitation and their Cognitive Outcomes in Schizophrenia: Review of Last Five-year Studies. 精神分裂症患者的精神康复策略及其认知结果:近五年研究综述。
Q2 Medicine Pub Date : 2021-05-24 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010031
Antonio Rampino, Rosa M Falcone, Arianna Giannuzzi, Rita Masellis, Linda A Antonucci, Silvia Torretta

Background: Cognitive deficits are core features of Schizophrenia, showing poor response to antipsychotic treatment, therefore non-pharmacological rehabilitative approaches to such a symptom domain need to be identified. However, since not all patients with Schizophrenia exhibit the same cognitive impairment profile, individualized rehabilitative approaches should be set up.

Objectives: We explored the last five-year literature addressing the issue of cognitive dysfunction response to rehabilitative methodologies in Schizophrenia to identify possible predictors of response and individualized strategies to treat such a dysfunction.

Conclusion: A total of 76 studies were reviewed. Possible predictors of cognitive rehabilitation outcome were identified among patient-specific and approach-specific variables and a general overview of rehabilitative strategies used in the last five years has been depicted. Studies suggest the existence of multifaced and multi-domain variables that could significantly predict pro-cognitive effects of cognitive rehabilitation, which could also be useful for identifying individual-specific rehabilitation trajectories over time.An individualized rehabilitative approach to cognitive impairment in Schizophrenia is possible if taking into account both patient and approach specific predictors of outcomes.

背景:认知缺陷是精神分裂症的核心特征,表现出对抗精神病药物治疗的不良反应,因此需要确定这种症状领域的非药物康复方法。然而,由于并非所有精神分裂症患者都表现出相同的认知障碍特征,因此应建立个性化的康复方法。目的:我们探讨了最近五年关于精神分裂症患者对康复方法的认知功能障碍反应问题的文献,以确定反应的可能预测因素和治疗这种功能障碍的个性化策略。结论:共回顾76项研究。在患者特异性和方法特异性变量中确定了认知康复结果的可能预测因素,并对过去五年中使用的康复策略进行了概述。研究表明,存在多方面和多领域的变量,这些变量可以显著预测认知康复的促认知效果,这也有助于识别个体随时间的康复轨迹。如果同时考虑到患者和方法特定的结果预测因素,则有可能对精神分裂症患者的认知障碍采取个性化的康复方法。
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引用次数: 3
Fear of COVID-19 among Peruvian People Living in Disadvantaged Communities: A Cross-Sectional Study. 秘鲁贫困社区居民对 COVID-19 的恐惧:一项横断面研究。
Q2 Medicine Pub Date : 2021-04-16 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010019
Carlos Sotomayor-Beltran, Hernan Matta-Solis, Rosa Perez-Siguas, Eduardo Matta-Solis, Lourdes Matta-Zamudio

Background: The COVID-19 crisis is fuelling a state of fear among the human population at global level. Especially, those living in informal settlements and slums worldwide have been profoundly impacted by this pandemic. Individuals living in these places are already leading underprivileged lives. Thus, the economic and mental health problems caused by the COVID-19 crisis have further exacerbated their living standards, which has resulted, for instance, in tragedies such as suicides.

Objective: In this study, we have sought to identify those individuals most at risk of displaying high levels of fear of COVID-19 in an informal settlement located in the capital city of Peru.

Methods: A questionnaire was administered to 449 inhabitants living in the Carmen Alto informal settlement. The questionnaire was made up of two parts: the first one inquired about demographic data and the second part consisted of the Fear of COVID-19 Scale.

Results: The demographic variables of age, gender, marital status, educational level, occupation, whether a relative from the household was infected with COVID-19, and whether one of them died of this showed significant differences. It could be observed as well that the groups of females, stable workers, unemployed and those having completed a workforce education are at higher odds of displaying high levels of fear of COVID-19. As expected, the groups that had either a relative infected with COVID-19 or a relative death by this had the highest levels of fear towards the virus.

Conclusion: The female participants are more likely to display higher levels of fear of COVID-19 due to the terrible effect that unfavorable events have on them. In the cases of the unemployed and stable workers, their proneness to show high levels of fear towards the virus is because they have lost their incomes, due to the loss of their jobs, and because of fear of infection, respectively. Hence, we hope that this work serves Peruvian (and other) health authorities to develop strategies that help individuals living in informal settlements and are in urgent need of mitigating mental health problems.

背景:COVID-19 危机在全球范围内加剧了人类的恐惧感。尤其是那些生活在世界各地非正规居住区和贫民窟的人们,更是深受这一流行病的影响。生活在这些地方的人们已经过着贫困的生活。因此,COVID-19 危机造成的经济和心理健康问题进一步加剧了他们的生活水平,导致了自杀等悲剧的发生:在这项研究中,我们试图找出秘鲁首都非正规居住区中最有可能对 COVID-19 表现出高度恐惧的人群:我们对居住在 Carmen Alto 非正规居住区的 449 名居民进行了问卷调查。问卷由两部分组成:第一部分询问人口统计学数据,第二部分是 COVID-19 恐惧量表:结果:年龄、性别、婚姻状况、教育程度、职业、家中是否有亲属感染 COVID-19,以及是否有亲属因此死亡等人口统计学变量均显示出显著差异。同时还可以发现,女性、稳定工作者、失业者和完成劳动力教育的人群对 COVID-19 表现出高度恐惧的几率更高。正如预期的那样,有亲属感染 COVID-19 或有亲属死于 COVID-19 的群体对该病毒的恐惧程度最高:结论:女性参与者更有可能对 COVID-19 表现出较高程度的恐惧,这是因为不利事件对她们产生了可怕的影响。在失业者和稳定工作者中,他们对病毒表现出高度恐惧的原因分别是失去收入、失去工作和害怕感染。因此,我们希望这项工作能够帮助秘鲁(和其他国家)的卫生当局制定战略,帮助生活在非正规住区、急需缓解心理健康问题的人。
{"title":"Fear of COVID-19 among Peruvian People Living in Disadvantaged Communities: A Cross-Sectional Study.","authors":"Carlos Sotomayor-Beltran, Hernan Matta-Solis, Rosa Perez-Siguas, Eduardo Matta-Solis, Lourdes Matta-Zamudio","doi":"10.2174/1745017902117010019","DOIUrl":"10.2174/1745017902117010019","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 crisis is fuelling a state of fear among the human population at global level. Especially, those living in informal settlements and slums worldwide have been profoundly impacted by this pandemic. Individuals living in these places are already leading underprivileged lives. Thus, the economic and mental health problems caused by the COVID-19 crisis have further exacerbated their living standards, which has resulted, for instance, in tragedies such as suicides.</p><p><strong>Objective: </strong>In this study, we have sought to identify those individuals most at risk of displaying high levels of fear of COVID-19 in an informal settlement located in the capital city of Peru.</p><p><strong>Methods: </strong>A questionnaire was administered to 449 inhabitants living in the Carmen Alto informal settlement. The questionnaire was made up of two parts: the first one inquired about demographic data and the second part consisted of the Fear of COVID-19 Scale.</p><p><strong>Results: </strong>The demographic variables of age, gender, marital status, educational level, occupation, whether a relative from the household was infected with COVID-19, and whether one of them died of this showed significant differences. It could be observed as well that the groups of females, stable workers, unemployed and those having completed a workforce education are at higher odds of displaying high levels of fear of COVID-19. As expected, the groups that had either a relative infected with COVID-19 or a relative death by this had the highest levels of fear towards the virus.</p><p><strong>Conclusion: </strong>The female participants are more likely to display higher levels of fear of COVID-19 due to the terrible effect that unfavorable events have on them. In the cases of the unemployed and stable workers, their proneness to show high levels of fear towards the virus is because they have lost their incomes, due to the loss of their jobs, and because of fear of infection, respectively. Hence, we hope that this work serves Peruvian (and other) health authorities to develop strategies that help individuals living in informal settlements and are in urgent need of mitigating mental health problems.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/40/CPEMH-17-19.PMC8097400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39036429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Malaysian Women's Experience of Care and Management of Postnatal Depression. 马来西亚妇女产后抑郁症的护理和管理经验。
Q2 Medicine Pub Date : 2021-04-13 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010010
Siti R B M Arifin, Helen Cheyne, Margaret Maxwell, Abdilahi Yousuf

Objectives: Early detection and intervention for Maternal Postnatal Depression (PND) are imperative to prevent devastating consequences for mothers, babies, and families. However, there are no guidelines that explicitly focus on the management of PND in Malaysia. Consequently, it is unclear whether women with PND are receiving proper care and treatment. Therefore, this study aimed to explore Malaysian Women's experience in managing PND symptoms.

Methods: A qualitative study was conducted among 33 women attending Maternal and Child Health (MCH) clinics in Kuala Lumpur. Data were obtained through a face-to-face semi-structured interview and analysed using framework analysis.

Results: The women considered PND as a personal and temporary issue. Therefore, professional care was deemed unnecessary for them. Additionally, all Malay women considered religious approach as their primary coping strategy for PND. However, this was not the case for most Indian and Chinese women.

Conclusion: The findings of this study indicated that women did not acknowledge the roles of Healthcare Practitioners (HCPs) in alleviating their emotional distress.Also, they perceived PND as a personal problem and less serious emotional condition. It is due to this perception that the women adopted self-help care as their primary coping strategy for PND. However, the coping strategy varied between different cultures. These findings underscore the importance of HCPs' proactive action to detect and alleviate PND symptoms as their attitude towards PND may influence Women's help-seeking behaviour.

目的:早期发现和干预产妇产后抑郁症(PND)是必要的,以防止对母亲,婴儿和家庭的破坏性后果。然而,在马来西亚没有明确关注PND管理的指导方针。因此,目前尚不清楚患有PND的妇女是否得到了适当的护理和治疗。因此,本研究旨在探讨马来西亚妇女在处理PND症状方面的经验。方法:对在吉隆坡妇幼保健诊所就诊的33名妇女进行定性研究。数据通过面对面半结构化访谈获得,并使用框架分析进行分析。结果:女性认为PND是个人的、暂时的问题。因此,专业护理对他们来说是不必要的。此外,所有马来妇女都认为宗教方法是她们应对PND的主要策略。然而,大多数印度和中国女性的情况并非如此。结论:本研究结果表明,妇女不承认保健医生(HCPs)在减轻其情绪困扰方面的作用。此外,他们认为PND是一种个人问题,不那么严重的情绪状况。正是由于这种认识,妇女采用自助护理作为她们应对产后抑郁症的主要策略。然而,不同文化的应对策略有所不同。这些发现强调了医护人员主动采取行动来发现和减轻PND症状的重要性,因为他们对PND的态度可能会影响妇女的求助行为。
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引用次数: 2
Erratum: Mediterranean Diet and its Benefits on Health and Mental Health: A Literature Review. 勘误:地中海饮食及其对健康和心理健康的益处:文献综述。
Q2 Medicine Pub Date : 2021-03-26 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010009
Antonio Ventriglio, Federica Sancassiani, Maria Paola Contu, Mariateresa Latorre, Melanie Di Salvatore, Michele Fornaro, Dinesh Bhugra

[This corrects the article on p. 156 in vol. 16, PMCID: 7536728.].

[此处更正了第 16 卷第 156 页的文章,PMCID:7536728]。
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引用次数: 0
Implementing WHO-Quality Rights Project in Tunisia: Results of an Intervention at Razi Hospital. 在突尼斯实施世卫组织质量权利项目:在Razi医院进行干预的结果。
Q2 Medicine Pub Date : 2021-02-19 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010008
Mauro Giovanni Carta, Rym Ghacem, Myriam Milka, Olfa Moula, Nidhal Staali, Uta Uali, Ghassene Boukhari, Monica Mannu, Rym Refrafi, Souha Yaakoubi, Maria Francesca Moro, Marie Baudel, Simon Vasseur-Bacle, Natalie Drew, Michelle Funk
{"title":"Implementing WHO-Quality Rights Project in Tunisia: Results of an Intervention at Razi Hospital.","authors":"Mauro Giovanni Carta,&nbsp;Rym Ghacem,&nbsp;Myriam Milka,&nbsp;Olfa Moula,&nbsp;Nidhal Staali,&nbsp;Uta Uali,&nbsp;Ghassene Boukhari,&nbsp;Monica Mannu,&nbsp;Rym Refrafi,&nbsp;Souha Yaakoubi,&nbsp;Maria Francesca Moro,&nbsp;Marie Baudel,&nbsp;Simon Vasseur-Bacle,&nbsp;Natalie Drew,&nbsp;Michelle Funk","doi":"10.2174/1745017902117010008","DOIUrl":"https://doi.org/10.2174/1745017902117010008","url":null,"abstract":"","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/06/CPEMH-17-8.PMC7931145.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25478597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Extrapyramidal Symptoms Associated with Psychotropics Pharmacological Treatments, and Associated Risk Factors. 评估与精神药物治疗相关的锥体外系症状及相关危险因素。
Q2 Medicine Pub Date : 2021-02-16 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010001
Dania Abu-Naser, Sara Gharaibeh, Ahmad Z Al Meslamani, Qais Alefan, Renad Abunaser

Background: Extrapyramidal Symptoms (EPS) are unwanted symptoms commonly originating from the use of certain medications. The symptoms can range from minimal discomfort to permanent involuntary muscular movements. The aims of the study were to examine the incidence of drug-induced extrapyramidal symptoms (di-EPS), associated risk factors, and clinical characteristics.

Methods: This is a retrospective, observational study of di-EPS conducted in outpatient clinics of Jordan using the longitudinal health database (Hakeem®) for data collection. Patients who received drugs with the risk of EPS during the period 2010-2020 were included and followed. Patients with any of the known underlying conditions that may cause EPS or were currently taking drugs that may mask the symptoms were excluded. Gender and age-matched control subjects were included in the study. The Statistical Package for Social Science (SPSS®) version 26 was used for data analysis.

Results: The final dataset included 34898 exposed patients and 69796 matched controls. The incidence of di-EPS ranged from 9.8% [Amitriptyline 25mg] to 28.9% (Imipramine 25mg). Baseline factors associated with a significantly higher risk of developing di-EPS were age {HR: 1.1 [95%CI: 0.8-1.2, p=0.003], smoking {HR: 1.7 (95%CI: 1.3-2.2), p=0.02}, tremor history {HR: 7.4 (95%CI: 5.9-8.3), p=.002} and history of taking antipsychotics {HR: 3.9, (95% CI: 2.5-4.6), p=0.001}. Patients taking paroxetine {HR: 8.6 [95%CI: 7.4-9.8], p=.0002},imipramine {HR: 8.3, [7.1-10.5], p=0.01}, or fluoxetine {HR: 8.2 (95%CI: 6.8-9.3), p=.006} had a significantly higher risk of developing di-EPS compared to patients taking citalopram. Myoclonus, blepharospasm, symptoms of the basal ganglia dysfunction, and organic writers' cramp were reported among participants.

Conclusion: Patients treated with paroxetine, imipramine, fluoxetine, or clomipramine had a higher risk of developing di-EPS than patients treated with citalopram. The difference in gender was not significantly related to di-EPS development. Whereas age, smoking, and history of taking antipsychotics were significantly associated with di-EPS development.

Key findings: • High incidence of drug-induced extrapyramidal symptoms (di-EPS) was reported• Age, smoking, tremor history, and history of taking antipsychotics were risk factors of drug-induced extrapyramidal symptoms.• Patients taking paroxetine, imipramine or fluoxetine had a significantly higher risk of developing di-EPS compared to patients taking citalopram.

背景:锥体外系症状(EPS)是不希望出现的症状,通常源于某些药物的使用。症状可以从轻微的不适到永久性的不自主肌肉运动。本研究的目的是检查药物性锥体外系症状(di-EPS)的发生率、相关危险因素和临床特征。方法:这是一项回顾性的观察性研究,在约旦门诊诊所使用纵向健康数据库(Hakeem®)进行数据收集。纳入2010-2020年期间接受有EPS风险药物治疗的患者并进行随访。患有任何已知可能导致EPS的潜在疾病或目前正在服用可能掩盖症状的药物的患者被排除在外。性别和年龄相匹配的对照组被纳入研究。使用社会科学统计软件包(SPSS®)版本26进行数据分析。结果:最终数据集包括34898名暴露患者和69796名匹配的对照组。双eps发生率从9.8%(阿米替林25mg)到28.9%(丙咪嗪25mg)不等。与低eps发生风险显著增高相关的基线因素为年龄{HR: 1.1 [95%CI: 0.8-1.2, p=0.003]、吸烟{HR: 1.7 (95%CI: 1.3-2.2), p=0.02}、震颤史{HR: 7.4 (95%CI: 5.9-8.3), p=0.003。002}和服用抗精神病药物史{HR: 3.9, (95% CI: 2.5 ~ 4.6), p=0.001}。服用帕罗西汀的患者{HR: 8.6 [95%CI: 7.4 ~ 9.8], p=。0002},丙咪嗪{人力资源:8.3 (7.1 - -10.5),p = 0.01},或氟西汀{人力资源:8.2(95%置信区间:6.8—-9.3),p =。006}与服用西酞普兰的患者相比,发生低eps的风险明显更高。参与者中有肌颤、眼睑痉挛、基底神经节功能障碍症状和器质性作家痉挛的报告。结论:帕罗西汀、丙咪嗪、氟西汀或氯丙咪嗪治疗的患者发生双eps的风险高于西酞普兰治疗的患者。性别差异与双eps发育无显著相关。而年龄、吸烟和服用抗精神病药物的历史与双eps的发生显著相关。•据报道,药物性锥体外系症状(dii - eps)的发生率很高•年龄、吸烟、震颤史和服用抗精神病药物史是药物性锥体外系症状的危险因素。•与服用西酞普兰的患者相比,服用帕罗西汀、丙咪嗪或氟西汀的患者发生双eps的风险明显更高。
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引用次数: 12
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Clinical Practice and Epidemiology in Mental Health
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