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Optical polymers for laser medical applications 用于激光医疗的光学聚合物
N. Sultanova, S. Kasarova, I. Nikolov
In medicine, optical polymers are used not only in ophthalmology but in many laser surgical, diagnostic and therapeutic systems. The application in lens design is determined by their refractive and dispersive properties in the considered spectral region. We have used different measuring techniques to obtain precise refractometric data in the visible and near-infrared spectral regions. Dispersive, thermal and other important optical characteristics of polymers have been studied. Design of a plastic achromatic objective, used in a surgical stereo-microscope at 1064 nm laser wavelength, is accomplished. Geometrical and wavefront aberrations are calculated. Another example of application of polymers is the designed all-mirror apochromatic micro-lens, intended for superluminescent diode fiber coupling in medical systems.
在医学上,光学聚合物不仅用于眼科,还用于许多激光手术、诊断和治疗系统。在透镜设计中的应用是由它们在考虑的光谱区域的折射和色散特性决定的。我们使用不同的测量技术在可见光和近红外光谱区域获得精确的折射数据。研究了聚合物的色散、热学和其他重要的光学特性。完成了用于1064nm激光波长外科立体显微镜的塑料消色差物镜的设计。计算几何像差和波前像差。聚合物应用的另一个例子是设计的全反射复消色差微透镜,用于医疗系统中的超发光二极管光纤耦合。
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引用次数: 1
Slow and fast light in five-level system 五级系统中快慢光
G. Grigoryan, E. Gazazyan, V. Paturyan
We have studied the propagation of light in M- and W-systems, and have demonstrated the possibility of such propagation with nonlinear group velocity being either less than (slow light) or greater than (superluminal propagation) of the speed of light in vacuum without being distorted.
我们研究了光在M-和w -系统中的传播,并证明了这种传播的可能性,非线性群速度要么小于(慢光),要么大于(超光速传播)的光速在真空中不被扭曲。
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引用次数: 0
Dispersion control in a folded 4-f system for shaping femtosecond laser pulses 用于成形飞秒激光脉冲的折叠4-f系统中的色散控制
N. Dimitrov, P. Lazarova, L. Stoyanov, I. Stefanov, A. Dreischuh
In this work we study the influence of the additional second-order dispersion introduced in sub-45 femtosecond laser pulses by intentional misaligning a folded 4-f otherwise dispersionless system. The theoretically calculated pulse durations are found to be in a good agreement with the respective experimental data from frequency-resolved optical gating measurements.
在这项工作中,我们研究了在45飞秒以下的激光脉冲中,通过故意错对准一个折叠的4-f或无色散系统,引入额外的二阶色散的影响。理论计算的脉冲持续时间与频率分辨光门测得的实验数据吻合较好。
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引用次数: 0
Nonlinear optical microscopy for investigation of gastrointestinal lesions 非线性光学显微镜用于胃肠道病变的研究
T. Genova, Ekaterina Borisova, G. Stanciu, D. Tranca, I. Terziev, N. Penkov, B. Vladimirov, M. Lomova, O. Semyachkina-Glushkovskaya, L. Avramov
The standard procedure for cancer detection includes rigorous biopsy protocols, which are costly and time consuming; also the accuracy of the current diagnostic procedure relays entirely on the physician’s experience and it is limited by the high probability of miss rates. Therefore new sensitive diagnostic modalities for analysis of biopsy tissue samples or on site, in vivo microscopy tissue examination, are necessary. In this study we present an investigation using nonlinear microscopy techniques for histological sections from biopsy tissue samples analysis. The samples were routinely processed for histological analysis and during the standard sampling the tissue slices were stained with hematoxylin and eosin dyes. The application of nonlinear microscopy techniques, such as two photon excitation fluorescence microscopy and second harmonic generation microscopy in biomedical research for cancer diagnosis has been vastly expanding in the last few years. Two-photon excitation fluorescence microscopy is based on a non-linear optical effect of simultaneously absorption of two photons, thus achieves excited state of the absorbing molecule with energy corresponding to the sum of the energies of two incident photons. This method allows for using an excitation wavelength which is double the typically required one for excitation of diagnostically valuable endogenous fluorophores. This results in more efficient depth penetration of the longer wavelength light in the tissue. The second harmonic generation microscopy is based on the principle of the non-linear susceptibility in noncentrosymmetric structures; such structures in the tissue are formed mainly by the collagen fibers. After excitation with near-infrared photons with wavelength λ of the collagen structures, photons with wavelength ½ λ are emitted — this corresponding to the second harmonic of the excitation beam’s frequency. The applied nonlinear microscopy techniques are suitable for detection and quantification of the morphological changes associated with stroma and epithelial transformation in colon cancer, providing complementary information about the tissue microstructure and displaying distinctive patterns between normal and malignant human colon tissues.
癌症检测的标准程序包括严格的活组织检查方案,这既昂贵又耗时;此外,目前诊断程序的准确性完全依赖于医生的经验,并受到高漏诊率的限制。因此,需要新的敏感的诊断方式来分析活检组织样本或现场,体内显微镜组织检查。在这项研究中,我们提出了一项使用非线性显微镜技术对活检组织样本进行组织学切片分析的研究。样品常规处理进行组织学分析,在标准取样期间,组织切片用苏木精和伊红染料染色。近年来,非线性显微镜技术,如双光子激发荧光显微镜和二次谐波产生显微镜在生物医学研究中的应用得到了极大的扩展。双光子激发荧光显微镜是基于同时吸收两个光子的非线性光学效应,从而达到吸收分子的激发态,其能量相当于两个入射光子的能量之和。该方法允许使用的激发波长是诊断有价值的内源性荧光团激发通常所需波长的两倍。这导致更有效的深度穿透较长波长的光在组织中。二次谐波产生显微镜是基于非中心对称结构的非线性磁化率原理;这种组织结构主要是由胶原纤维形成的。在胶原蛋白结构的波长为λ的近红外光子激发后,波长为½λ的光子被发射出来——这对应于激发光束频率的二次谐波。所应用的非线性显微技术适用于结肠癌中基质和上皮转化相关的形态学变化的检测和定量,提供了组织微观结构的补充信息,并显示了正常和恶性人类结肠组织之间的独特模式。
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引用次数: 0
Detection of plum pox virus infection in selection plum trees using spectral imaging 利用光谱成像技术检测梅树梅痘病毒感染
L. Angelova, A. Stoev, E. Borisova, L. Avramov
Plum pox virus (PPV) is among the most studied viral diseases in the world in plants. It is considered to be one of the most devastating diseases of stone fruits in terms of agronomic impact and economic importance. Noninvasive, fast and reliable techniques are required for evaluation of the pathology in selection trees with economic impact. Such advanced tools for PPV detection could be optical techniques as light-induced fluorescence and diffuse reflectance spectroscopies. Specific regions in the electromagnetic spectra have been found to provide information about the physiological stress in plants, and consequently, diseased plants usually exhibit different spectral signature than non-stressed healthy plants in those specific ranges. In this study spectral reflectance and chlorophyll fluorescence were used for the identification of biotic stress caused by the pox virus on plum trees. The spectral responses of healthy and infected leaves from cultivars, which are widespread in Bulgaria were investigated. The two applied techniques revealed statistically significant differences between the spectral data of healthy plum leaves and those infected by PPV in the visible and near-infrared spectral ranges. Their application for biotic stress detection helps in monitoring diseases in plants using the different plant spectral properties in these spectral ranges. The strong relationship between the results indicates the applicability of diffuse reflectance and fluorescence techniques for conducting health condition assessments of vegetation and their importance for plant protection practices.
李痘病毒(Plum pox virus, PPV)是世界上研究最多的植物病毒性疾病之一。就农业影响和经济重要性而言,它被认为是核果中最具破坏性的疾病之一。需要无创、快速和可靠的技术来评估具有经济影响的选择树的病理。这种先进的PPV检测工具可以是光学技术,如光诱导荧光和漫反射光谱。电磁光谱中的特定区域提供了植物生理胁迫的信息,因此,在这些特定范围内,患病植物通常表现出与未受胁迫的健康植物不同的光谱特征。利用光谱反射和叶绿素荧光技术对李树痘病毒的生物胁迫进行了鉴定。对保加利亚广泛分布的不同品种的健康叶片和感染叶片的光谱反应进行了研究。两种技术的应用表明,在可见光和近红外光谱范围内,健康李叶与PPV侵染李叶的光谱数据差异有统计学意义。它们在生物胁迫检测中的应用有助于利用这些光谱范围内不同的植物光谱特性来监测植物的病害。结果之间的强相关性表明漫反射和荧光技术在进行植被健康状况评估中的适用性及其在植物保护实践中的重要性。
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引用次数: 3
Laser annealing of metal nanoparticles synthesized in glasses by ion implantation 离子注入玻璃中合成金属纳米粒子的激光退火
A. Stepanov
Recent results on the interaction of high power laser pulses with dielectrics containing metal nanoparticles are observed. The excimer laser pulse modification of copper nanoparticles synthesized by ion implantation in silicate glass are considered. Pulsed laser irradiation makes it possible to modify such composite layer, improving the uniformity in the size distribution of the nanoparticles. Changes induced by pulsed laser exposure suggest there are both reductions in average size of the metal nanoparticles, and some long-range dissolution of metal atoms in the matrix. Experimental data on laser modification are explained by photofragmentation of the nanoparticles in the dielectric matrix.
观察了高功率激光脉冲与含金属纳米粒子介电体相互作用的最新结果。研究了在硅酸盐玻璃中离子注入合成的准分子激光脉冲修饰铜纳米粒子。脉冲激光照射使改性复合层成为可能,提高了纳米颗粒尺寸分布的均匀性。脉冲激光照射引起的变化表明,金属纳米颗粒的平均尺寸减小,金属原子在基体中的一些远程溶解。用介电基质中纳米颗粒的光破碎来解释激光修饰实验数据。
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引用次数: 0
Three-dimensional imaging of cultural heritage artifacts with holographic printers 用全息打印机对文物进行三维成像
Hoonjong Kang, E. Stoykova, N. Berberova, Jiyong Park, D. Nazarova, J. Park, Youngmin Kim, Sunghee Hong, B. Ivanov, N. Malinowski
Holography is defined as a two-steps process of capture and reconstruction of the light wavefront scattered from three-dimensional (3D) objects. Capture of the wavefront is possible due to encoding of both amplitude and phase in the hologram as a result of interference of the light beam coming from the object and mutually coherent reference beam. Three-dimensional imaging provided by holography motivates development of digital holographic imaging methods based on computer generation of holograms as a holographic display or a holographic printer. The holographic printing technique relies on combining digital 3D object representation and encoding of the holographic data with recording of analog white light viewable reflection holograms. The paper considers 3D contents generation for a holographic stereogram printer and a wavefront printer as a means of analogue recording of specific artifacts which are complicated objects with regards to conventional analog holography restrictions.
全息被定义为捕获和重建从三维(3D)物体散射的光波前的两步过程。由于来自物体的光束和相互相干的参考光束的干涉,在全息图中对振幅和相位进行编码,波前的捕获是可能的。全息技术所提供的三维成像技术促进了基于计算机生成全息图作为全息显示器或全息打印机的数字全息成像方法的发展。全息印刷技术依赖于将数字三维物体表示和全息数据编码与模拟白光可见反射全息图的记录相结合。本文考虑了全息立体图打印机和波前打印机的三维内容生成,作为一种模拟记录特定工件的手段,这些工件是传统模拟全息限制的复杂对象。
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引用次数: 4
Determination of gas-discharge plasma parameters in powerful metal halide vapor lasers 强金属卤化物蒸气激光器气体放电等离子体参数的测定
K. Temelkov, S. I. Slaveeva, Yu I Fedchenko
Powerful metal halide vapor lasers are excited with nanosecond pulsed longitudinal discharge in complex multicomponent gas mixtures. Using a new method, thermal conductivity of various 5- and 6-component gas mixtures is obtained under gas-discharge conditions, which are optimal for laser operation on the corresponding metal atom and ion transitions. Assuming that the gas temperature varies only in the radial direction and using the calculated thermal conductivities, an analytical solution of the steady-state heat conduction equation is found for uniform and radially nonuniform power input in various laser tube constructions. Using the results obtained for time-resolved electron temperature by measurement of electrical discharge characteristics and analytically solving steady-state heat conduction equation for electrons as well, radial distribution of electron temperature is also obtained for the discharge period.
用纳秒脉冲纵向放电在复杂的多组分气体混合物中激发强大的金属卤化物蒸汽激光器。利用一种新的方法,在气体放电条件下,获得了各种5组分和6组分气体混合物的热导率,这些热导率最适合激光对相应金属原子和离子跃迁进行操作。假设气体温度只在径向上变化,利用计算得到的热导率,得到了各种激光管结构中均匀和径向非均匀输入功率的稳态热传导方程的解析解。利用测量放电特性得到的时间分辨电子温度,并解析求解电子稳态热传导方程,得到了放电周期内电子温度的径向分布。
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引用次数: 1
Slow terahertz light via resonant tunneling induced transparency in quantum well heterostructures 慢太赫兹光通过共振隧道诱导量子阱异质结构的透明
P. Tzenov, C. Jirauschek
We present a theoretical and computational investigation of the possibility of achieving slow terahertz light by exploiting the tunneling induced transparency (TIT) effect in suitably engineered quantum well heterostructure devices. We design such a meta-material and show how TIT could lead to large values of the group refractive index, unfortunately at the cost of strong field attenuation due to decoherence. As a suitable alternative, we propose a grating, consisting of a buffer and a quantum cascade amplifier regions, arranged in such a way as to achieve slow light and simultaneously compensate for the large signal losses. Our calculations show that a binary message could be reliably transmitted through this system, with non-critical reduction of the signal to noise ratio, as we achieve a slow-down factor of more than 70.
我们提出了一个理论和计算研究的可能性,通过利用隧道诱导透明(TIT)效应在适当的工程量子阱异质结构器件实现慢太赫兹光。我们设计了这样一种超材料,并展示了TIT如何导致大的群折射率,不幸的是,这是以退相干引起的强场衰减为代价的。作为一个合适的替代方案,我们提出了一个光栅,由一个缓冲器和一个量子级联放大器区域组成,以这样一种方式排列,以实现慢光,同时补偿大的信号损失。我们的计算表明,通过该系统可以可靠地传输二进制消息,并且可以非临界地降低信噪比,因为我们实现了超过70的减速因子。
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引用次数: 2
Optimal contrast elastic lidar sensing of clear and aerosol-loaded atmosphere 清晰和气溶胶负载大气的最佳对比度弹性激光雷达传感
T. Evgenieva, L. Gurdev
The sensing laser radiation wavelength is one of the most significant factors conditioning the elastic lidar efficiency. Nevertheless, its role in the process of lidar sensing has not been investigated systematically so far. Therefore, the main purpose of the present work is to develop and perform an initial examination of an approach to solve this problem based on modeling the profile of the lidar return signal (the lidar profile) and evaluating, in a specific way, the corresponding profile of the measurement signal-to-noise ratio (SNR). The measurement fluctuations are considered as mainly due to the Poisson shot noise that is intrinsic to the dark current and the photocurrent induced by the useful signal itself and the atmospheric background. The initial results obtained show for instance that for ground-based lidar facilities the maximum Rayleigh return signal is obtainable at wavelengths about 350nm. The roles are changed when sensing clouds using wavelength from 400nm to 1000-2000nm. Then, the longer wavelengths provide higher return power from clouds, and the effect is magnified in aerosol-loaded (and especially hazy) atmosphere. The results of such investigations are useful when selecting optimal lidar-design characteristics ensuring maximum brightness and contrast of the lidar-acquired images of specific aerosol strata and objects in the atmosphere.
传感激光辐射波长是影响弹性激光雷达效率的重要因素之一。然而,其在激光雷达传感过程中的作用尚未得到系统的研究。因此,本研究的主要目的是开发并初步研究一种解决这一问题的方法,该方法基于对激光雷达回波信号的轮廓(激光雷达轮廓)进行建模,并以特定的方式评估测量信噪比(SNR)的相应轮廓。测量波动主要是由于暗电流和有用信号本身及大气背景所产生的光电流所固有的泊松散粒噪声引起的。获得的初步结果表明,例如,对于地面激光雷达设施,最大瑞利返回信号的波长约为350nm。当波长从400nm到1000-2000nm时,角色发生了变化。然后,较长的波长从云层中提供更高的返回功率,并且在气溶胶负载(特别是朦胧的)大气中效果被放大。这些研究的结果在选择最佳的激光雷达设计特性时是有用的,以确保激光雷达获得的大气中特定气溶胶层和物体的图像的最大亮度和对比度。
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引用次数: 3
期刊
International School on Quantum Electronics: Laser Physics and Applications
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