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[Specialized medical care for facial injuries]. [对面部损伤的专门医疗护理]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510404137
A A Kulakov, O D Maday, G A Grebnev, A S Bagnenko, D Yu Maday

Objective: To analyze the results of specialized medical care (SMC) to the injured in the maxillofacial region using the principles of multi-stage surgical treatment.

Material and methods: To achieve the purpose of the study, the results of surgical treatment of the wounded with combat wounds of the maxillofacial region in military medical hospitals and medical institutions performing qualified and specialized care were analyzed. Clinical examination, observation and treatment were carried out using a comprehensive multidisciplinary approach (examination by an anesthesiologist, intensive care specialist, neurosurgeon, maxillofacial surgeon, traumatologist, surgeon, ophthalmologist and otolaryngologist). Qualified medical care was provided for urgent indications (elimination of asphyxia and control of continuing bleeding. fixation of bone fragments). SSC requires the participation of high-class specialists and appropriate equipment to achieve maximum quality of treatment.

Results: According to the experience of combat operations in the Republic of Afghanistan and the counter-terrorism operation in the North Caucasus, isolated and combined (leading damage to the maxillofacial region) MFZ injuries in the overall structure of combat surgical trauma amounted to 4.3% and 4.5-5.0%, respectively, taking into account concomitant wounds - 8.5% and 8.3-10.7%.

Conclusion: Multi-stage surgical treatment tactics in the specialized medical care section led to a 3.4% decrease in mortality; the number of complications decreased by 2 times; the number of bed days in the ICU decreased by 1.8 times; the duration of functional and aesthetic rehabilitation of casualties decreased.

目的:分析应用多阶段手术治疗原则对颌面部外伤患者进行专科医疗护理的效果。材料与方法:为达到研究目的,对军队医院和专科医疗机构对颌面部作战伤伤员的外科治疗结果进行分析。临床检查、观察和治疗采用综合多学科方法(由麻醉科医生、重症监护专科医生、神经外科医生、颌面外科医生、创伤科医生、外科医生、眼科医生和耳鼻喉科医生检查)。为紧急指征(消除窒息和控制持续出血)提供了合格的医疗服务。骨碎片的固定)。SSC需要高级专家的参与和适当的设备,以达到最高的治疗质量。结果:根据阿富汗共和国作战行动和北高加索反恐行动的经验,孤立和联合(导致颌面部损伤)MFZ损伤在作战外科创伤的整体结构中分别占4.3%和4.5-5.0%,考虑到伴随伤- 8.5%和8.3-10.7%。结论:专科医疗科采用多阶段手术治疗策略,死亡率降低3.4%;并发症减少2倍;ICU住院天数减少1.8倍;伤亡者的功能和审美恢复时间缩短。
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引用次数: 0
[Comparative characteristics of the torque and primary stability values of dental implants with «classical» and «active» threads placed in low-density bone by various techniques]. [通过各种技术将“经典”和“主动”螺纹置入低密度骨中的牙种植体的扭矩和初级稳定性值的比较特征]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510403146
B A Kudzaev, V A Badalyan, E M Chernovol, A P Vedyaeva, A V Kuzin

The aim of the study: Was the analysis of the values of torque and primary stability of dental implants with «classical» and «active» threads, placed in low-density bone with different methods.

Material and methods: Implants were placed into the cancellous bone of pig's breastbone that represents low-density bone. Specimens were divided into 2 groups according to used protocols with 10 samples of each type with «classical» and «active» threads, 40 implants overall. In the first group osteotomy was performed according to the standard technique using the cutting drills, in the second one using osseodensification method. The torque was measured during implantation with physiodispenser and the implant stability quotient with the help of Osstell Beacon device.

Results: Comparative analysis of obtained values showed statistically significant difference with the advantage of using osseodensification protocol in each case. For example, the median torque value of the implants placed by the standard protocol was 15 N/cm and 44 N/cm when using osseodensification method. When comparing implants with «classical» threads, the median value of torque was 15.5 N/cm in the first group and 52.5 N/cm in the second group, and the arithmetic mean of ISQ when using the Smartpeg pin was 69 and 78 units, respectively. A similar result was obtained when comparing implants with «active» threads, in which the arithmetic mean of the torque in the first group was 13.5 N/cm and 35.8 N/cm in the second group, and the stability quotient when using the Smartpeg pin was 67 and 77.1 units, respectively. When using implants with «classical» thread design with an osseodensification protocol hypertorque was obtained.

Conclusion: When working in low-density bone the use of a standard preparation protocol is ineffective, unlike the osseodensification method. The use of the latter with implants with a classic «non-aggressive» macro design should be carried out carefully.

本研究的目的是分析“经典”和“主动”螺纹牙种植体的扭矩值和初级稳定性,以不同的方法放置在低密度骨中。材料和方法:将植入物置入猪胸骨的松质骨中,松质骨代表低密度骨。标本根据使用的方案分为两组,每种类型10个样本,“经典”和“活动”螺纹,共40个种植体。第一组采用标准截骨技术,采用切削钻头,第二组采用骨密度法。利用植体分配器测量植体植入时的扭矩,利用Osstell Beacon装置测量植体稳定商。结果:所得值对比分析显示,各病例采用骨化方案的优势有统计学意义。例如,采用标准方案放置的种植体的中位扭矩值为15 N/cm,采用骨密度法放置的种植体的中位扭矩值为44 N/cm。当将植入物与“经典”螺纹进行比较时,第一组的扭矩中位数为15.5 N/cm,第二组为52.5 N/cm,使用Smartpeg引脚时ISQ的算术平均值分别为69和78个单位。当比较“活动”螺纹的种植体时,获得了类似的结果,其中第一组的扭矩算术平均值为13.5 N/cm,第二组为35.8 N/cm,使用Smartpeg引脚时的稳定商分别为67和77.1单位。当使用具有“经典”螺纹设计和骨密度协议的种植体时,获得了超扭矩。结论:当在低密度骨中工作时,使用标准制备方案是无效的,不像骨密度方法。后者与具有经典“非侵袭性”宏设计的植入物的使用应谨慎进行。
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引用次数: 0
[TMJ features MRI study in patients with complete edentia in the absence of clinical manifestations of TMJ dysfunction]. [完全性痴呆患者无颞下颌关节功能障碍临床表现的TMJ特征MRI研究]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510401150
S I Abakarov, D A Lezhnev, A V Basov, A S Abakarova, A V Starodubova, E A Yegorova

The aim of the study: Was to determine the signs of TMJ dysfunction in patients with complete removable dentures who did not complain of discomfort or pain.

Materials and methods: The study included 264 patients with complete absence of teeth, who had complete removable dentures for at least 6 months. Two groups of subjects were formed, 20 of whom (the control group) had no clinical signs, MRI examination in the TMJ did not reveal any pathological changes, and manual examination did not reveal pathological symptoms. The remaining 244 patients formed the main group, who also did not complain of any complaints. In these patients, tooth extractions were performed 6-12 months ago.

Results: In the main group, it was determined that only 36 patients (15%) presented complaints when using complete removable dentures, and 224 patients (85%) had no symptoms, and crunching and clicking in the TMJ, accompanied by discomfort and minor pain were observed in 7 patients (20% of those presenting complaints). According to the results of the MRI study, it was determined that all 56 patients regardless of gender have an asymmetry in the shape of the articular heads and their sclerotic changes, 44 patients with complete edentia showed a posterior displacement of the joint heads and a narrowing of the joint space. At the same time 46 of the 56 patients were over 70 years old and used dentures for more than 4 years, a visual examination determined a decrease in the height of the lower part of the face, including due to the wear of artificial teeth installed in the denture.

Conclusion: Thus, it has been determined that a significant number of patients using complete removable dentures have dysfunctional disorders in the temporomandibular joint, which are detected only by special examination methods. This category of patients does not seek dental care from medical organizations due to the absence of complaints of painful sensations.

该研究的目的是:确定没有抱怨不适或疼痛的全活动义齿患者TMJ功能障碍的迹象。材料与方法:本研究纳入264例全牙缺失患者,均使用全口可摘义齿至少6个月。分为两组,其中20例(对照组)无临床体征,颞下颌关节MRI检查未见病理改变,手工检查未见病理症状。剩下的244名患者构成了主要组,他们也没有任何抱怨。这些患者在6-12个月前拔牙。结果:在主组中,仅36例(15%)患者在使用全口可摘义齿时出现主诉,224例(85%)患者无症状,7例(占主诉患者的20%)患者出现颞下颌关节嘎吱声、咔嗒声并伴有不适和轻微疼痛。根据MRI研究结果,56例患者不分性别均存在关节头形状不对称及硬化改变,44例完全性痴呆患者关节头后侧移位,关节间隙变窄。同时56例患者中有46例年龄超过70岁,假牙使用时间超过4年,目视检查确定面部下部高度下降,包括假牙安装磨损所致。结论:使用全口可摘义齿的患者中,有相当一部分存在颞下颌关节功能失调性疾病,这些疾病只有通过特殊的检查方法才能发现。这类患者不向医疗机构寻求牙科护理,因为没有痛感的抱怨。
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引用次数: 0
[Three-dimensional evaluation of stability of maxillary displacement after surgically assisted maxillary expansion in adult patients with cleft lip and palate]. [成人唇腭裂患者手术辅助上颌扩张术后上颌移位稳定性的三维评价]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510402148
T Z Chkadua, G V Sogachev, T D Cholokava, S V Tekucheva, V A Voronin, M B Khamhoev

The aim of the study: Was to investigate the dynamics of maxillary movement after surgically assisted maxillary expansion in adult patients with cleft lip and palate.

Material and methods: The study involved 15 adult patients aged 18-47 divided into three groups based on upper jaw pathology. Group 1 consisted of 5 patients with the diagnosis of «Upper micrognathia», group 2 included 5 patients with «Upper micrognathia after a series of surgeries for unilateral cleft lip and palate» and group 3 comprised 5 patients with diagnosis of «Upper micrognathia after a series of surgeries for bilateral cleft lip and palate». Movement of the maxillary fragments was measured 3 and 6 months after activation using cone beam computed tomography and intraoral scanner data. The data was analyzed using specialized software Amira 5.4.5 to create a 3D-model of the upper jaw. This allowed for precise measurement and analysis of the movement of the maxilla over time.

Results: Despite the initial goal of surgically assisted maxillary expansion being to correct transverse deficits it has been found that spatial changes occur in all planes and axes. Patients with upper micrognathia resulting from bilateral cleft lip and palate are more likely to experience recurrence of displacement of the fragments of the upper jaw following expansion, compared to patients with a unilateral cleft during the postoperative period. The most favorable stability indicators were noted among patients without clefts.

Conclusion: Comparison of three-dimensional jaw models obtained from CT and intraoral scanning data allows for accurate visualization and calculation of changes occurring in the postoperative period and can be the method of choice in dynamic monitoring of patients.

本研究的目的是探讨成人唇腭裂患者手术辅助上颌扩张后上颌运动的动力学。材料与方法:研究对象为15例18-47岁的成年患者,根据上颌病理分为三组。组1包括5例诊断为“上小颌”的患者,组2包括5例诊断为“单侧唇裂和腭裂一系列手术后上小颌”的患者,组3包括5例诊断为“双侧唇裂和腭裂一系列手术后上小颌”的患者。使用锥形束计算机断层扫描和口内扫描数据测量激活后3和6个月上颌碎片的运动。使用专门的软件Amira 5.4.5对数据进行分析,以创建上颌的3d模型。这使得精确测量和分析上颌骨随时间的运动成为可能。结果:尽管手术辅助上颌扩张的最初目标是纠正横向缺陷,但已经发现空间变化发生在所有平面和轴上。与单侧唇腭裂患者相比,双侧唇腭裂导致的上颌骨小畸形患者在术后扩张后更容易出现上颌碎片移位的复发。在没有唇裂的患者中,稳定性指标最有利。结论:对比CT和口腔内扫描数据获得的三维颌骨模型,可以准确地可视化和计算术后发生的变化,是患者动态监测的首选方法。
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引用次数: 0
[Selection of compression-distraction device type for mandibular hypoplasia based on mandible morphometric parameters]. [基于下颌骨形态计量学参数选择下颌骨发育不全的压张装置类型]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510406238
F F Losev, P I Shapovalov, A A Kulakov

Objective: To determine the optimal type of compression distraction device (CDA) for the treatment of mandibular underdevelopment in children.

Materials and methods: The archival data of 50 pediatric patients with underdevelopment of the mandible of various etiologies were analyzed. The patients were divided into two groups: group 1 with congenital pathology (syndrome I-II of the branchial arch, unilateral lesion) Group 2 with acquired pathology (consequences of TMJ ankylosis or injury of the condylar process without ankylosis). According to CT data, the length of the body and the height of the mandibular branch on the affected and intact sides were determined, and the degree of asymmetry was calculated. Depending on the nature of the deformation, either a rectilinear intraosseous distractor or a curved one (with a radius of curvature R40-R100) was used. The distribution of types of devices into groups and the correspondence of the choice of KDA to morphometric indicators were evaluated.

Results: In both groups, the majority of cases (≈90%) required the use of curved distractors, while direct devices were used in only 5 patients (10%). Rectilinear distractors were installed mainly with an isolated horizontal shortening of the mandible body, or with an isolated decrease in the height of the branch. The curved devices made it possible to simultaneously lengthen the body and the mandible branch in one step, eliminating the combination of horizontal and vertical deficits. The radius of curvature was selected individually: for severe vertical underdevelopment of the branch (hemifacial microsomy), a smaller radius (R40) was used, whereas for post-traumatic underdevelopment without a significant decrease in height, a larger radius (R70-R100) was used. In both groups, a significant elongation of the mandible was achieved: an increase in body length averaged 12-14 mm, and the height of the branch was 15-17 mm, which practically eliminated the initial asymmetry.

Conclusion: In children with combined mandibular underdevelopment, the use of intraoral curved distractors is optimal, which simultaneously compensate for horizontal and vertical deficits. Rectilinear QDs can only be used for isolated shortening in one direction (only the length of the body or only the height of the branch).

目的:探讨治疗儿童下颌骨发育不全的最佳压迫牵引装置(CDA)类型。材料与方法:对50例不同病因的小儿下颌骨发育不全患者的档案资料进行分析。将患者分为两组:1组为先天性病理(鳃弓I-II型综合征,单侧病变);2组为后天性病理(颞下颌关节强直或髁突损伤所致,无强直)。根据CT数据,确定患侧和完好侧下颌骨分支的体长和高度,并计算不对称程度。根据变形的性质,可以使用直线骨内牵牵器或弯曲牵牵器(曲率半径为R40-R100)。评估了器械类型的分组分布以及KDA选择与形态计量指标的对应关系。结果:两组中绝大多数(≈90%)患者需要使用弯曲牵张器,仅5例(10%)患者使用直接牵张器。直线牵张器的安装主要是使下颌骨孤立地水平缩短,或使分支的高度孤立地降低。弯曲的装置可以同时延长身体和下颌骨分支一步,消除水平和垂直缺陷的组合。曲率半径是单独选择的:对于严重的分支垂直发育不全(半面微体),使用较小的半径(R40),而对于创伤后发育不全且高度没有明显下降的情况,使用较大的半径(R70-R100)。在两组中,下颌骨都实现了显著的伸长:体长平均增加12-14毫米,分支高度为15-17毫米,这实际上消除了最初的不对称。结论:对于合并下颌骨发育不全的儿童,使用弯曲型口内牵张器可同时补偿水平和垂直缺陷。直线量子点只能用于在一个方向上孤立地缩短(仅体的长度或仅分支的高度)。
{"title":"[Selection of compression-distraction device type for mandibular hypoplasia based on mandible morphometric parameters].","authors":"F F Losev, P I Shapovalov, A A Kulakov","doi":"10.17116/stomat202510406238","DOIUrl":"https://doi.org/10.17116/stomat202510406238","url":null,"abstract":"<p><strong>Objective: </strong>To determine the optimal type of compression distraction device (CDA) for the treatment of mandibular underdevelopment in children.</p><p><strong>Materials and methods: </strong>The archival data of 50 pediatric patients with underdevelopment of the mandible of various etiologies were analyzed. The patients were divided into two groups: group 1 with congenital pathology (syndrome I-II of the branchial arch, unilateral lesion) Group 2 with acquired pathology (consequences of TMJ ankylosis or injury of the condylar process without ankylosis). According to CT data, the length of the body and the height of the mandibular branch on the affected and intact sides were determined, and the degree of asymmetry was calculated. Depending on the nature of the deformation, either a rectilinear intraosseous distractor or a curved one (with a radius of curvature R40-R100) was used. The distribution of types of devices into groups and the correspondence of the choice of KDA to morphometric indicators were evaluated.</p><p><strong>Results: </strong>In both groups, the majority of cases (≈90%) required the use of curved distractors, while direct devices were used in only 5 patients (10%). Rectilinear distractors were installed mainly with an isolated horizontal shortening of the mandible body, or with an isolated decrease in the height of the branch. The curved devices made it possible to simultaneously lengthen the body and the mandible branch in one step, eliminating the combination of horizontal and vertical deficits. The radius of curvature was selected individually: for severe vertical underdevelopment of the branch (hemifacial microsomy), a smaller radius (R40) was used, whereas for post-traumatic underdevelopment without a significant decrease in height, a larger radius (R70-R100) was used. In both groups, a significant elongation of the mandible was achieved: an increase in body length averaged 12-14 mm, and the height of the branch was 15-17 mm, which practically eliminated the initial asymmetry.</p><p><strong>Conclusion: </strong>In children with combined mandibular underdevelopment, the use of intraoral curved distractors is optimal, which simultaneously compensate for horizontal and vertical deficits. Rectilinear QDs can only be used for isolated shortening in one direction (only the length of the body or only the height of the branch).</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"104 6. Vyp. 2","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study of the physicomechanical properties and hydrolysis resistance of materials based on photopolymerizable hyaluronic acid and polyethyleneglycol diacrylate composites]. 【光聚合透明质酸与聚乙二醇二丙烯酸酯复合材料的物理力学性能及耐水解性能研究】。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat20251040625
I S Rudik, K E Tartakovsky, A V Sochilina, A G Dunaev, A V Mironov, A V Vasiliev

Objective: The aim of this study was to develop and characterize the properties of biocompatible photopolymerizable composites based on hyaluronic acid and polyethyleneglycol diacrylate.

Materials and methods: A method for chemical modification of hyaluronic acid using glycidyl methacrylate was considered. The influence of the composition of photopolymerizable polymer composites on their physical and mechanical properties, swelling rate, and resistance to degradation in vitro was studied. A comparative analysis of the effectiveness of type I photoinitiators was conducted.

Results: Photopolymerizable composites containing methacrylated hyaluronic acid showed greater structural strength and a lower swelling rate in the cured samples. The highest values of strength and hydrolytic stability were demonstrated by the photopolymerizable composition containing 0.5% wt. of lithium phenyl (2.4,6-trimethylbenzoylphosphinate), 15% wt. of methacrylated hyaluronic acid and 25% wt. of polyethylene glycol diacrylate.

Conclusion: Based on the study's results, it was concluded that polymeric materials with optimal mechanical properties and controlled degradation rates can be created by incorporating them into methacrylated hyaluronic acid.

目的:研究透明质酸与聚乙二醇二丙烯酸酯生物相容性光聚合复合材料的性能。材料与方法:研究了用甲基丙烯酸缩水甘油酯对透明质酸进行化学改性的方法。研究了光聚合聚合物复合材料的组成对其物理力学性能、体外溶胀率和抗降解性能的影响。对I型光引发剂的效果进行了对比分析。结果:含有甲基丙烯酸透明质酸的光聚合复合材料在固化样品中表现出更高的结构强度和更低的溶胀率。光聚合组合物中含有0.5%重量的苯基锂(2.4,6-三甲基苯甲酰膦酸盐)、15%重量的甲基丙烯酸透明质酸和25%重量的聚乙二醇二丙烯酸酯,其强度和水解稳定性最高。结论:根据研究结果,将其掺入甲基丙烯酸透明质酸中可以制备出具有最佳力学性能和可控制降解率的聚合物材料。
{"title":"[Study of the physicomechanical properties and hydrolysis resistance of materials based on photopolymerizable hyaluronic acid and polyethyleneglycol diacrylate composites].","authors":"I S Rudik, K E Tartakovsky, A V Sochilina, A G Dunaev, A V Mironov, A V Vasiliev","doi":"10.17116/stomat20251040625","DOIUrl":"https://doi.org/10.17116/stomat20251040625","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to develop and characterize the properties of biocompatible photopolymerizable composites based on hyaluronic acid and polyethyleneglycol diacrylate.</p><p><strong>Materials and methods: </strong>A method for chemical modification of hyaluronic acid using glycidyl methacrylate was considered. The influence of the composition of photopolymerizable polymer composites on their physical and mechanical properties, swelling rate, and resistance to degradation <i>in vitro</i> was studied. A comparative analysis of the effectiveness of type I photoinitiators was conducted.</p><p><strong>Results: </strong>Photopolymerizable composites containing methacrylated hyaluronic acid showed greater structural strength and a lower swelling rate in the cured samples. The highest values of strength and hydrolytic stability were demonstrated by the photopolymerizable composition containing 0.5% wt. of lithium phenyl (2.4,6-trimethylbenzoylphosphinate), 15% wt. of methacrylated hyaluronic acid and 25% wt. of polyethylene glycol diacrylate.</p><p><strong>Conclusion: </strong>Based on the study's results, it was concluded that polymeric materials with optimal mechanical properties and controlled degradation rates can be created by incorporating them into methacrylated hyaluronic acid.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"104 6. Vyp. 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Alveolar ridge bone augmentation using gene-activated bone substitute: long-term clinical follow-up]. [基因激活骨替代物的牙槽嵴骨增强:长期临床随访]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510406256
I Y Bozo, A Y Drobyshev, N A Redko, G A Volozhin, E V Presnyakov, R V Deev

Objective: To evaluate the long-term clinical results of the gene-activated bone substitute based on octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor in bone grafting for dental implantation.

Materials and methods: This clinical study analyzed the long-term treatment results of 100 patients with alveolar ridge atrophy and acquired bone defects of the jaws who underwent bone grafting with gene-activated bone substitute, starting with registration clinical trials initiated in 2017. All patients enrolled in the study underwent bone grafting of the upper or lower jaws using the gene-activated bone substitute in standard surgeries (sinus lifting, guided bone augmentation, cystectomy, etc.). The results of delayed clinical observation were assessed at different time points from 6 months to 7 years after bone grafting using clinical methods and computed tomography (CT), as well as histological analysis of trephine biopsy specimens.

Results: Newly formed tissues of bone density were detected in the bone grafting area in all patients within 6 months after surgery. The density remained at a high level during 7 years of follow-up. The volume of the newly formed tissues was maintained with minimal resorption: the decrease in volume was 12±5.9%. Histologically, newly-formed bone tissue with partially resorbed bone substitute fragments were indentified in trephine biopsy specimens.

Conclusion: Thus, the gene-activated bone substitute has proven its safety and long-term effectiveness in jaw bone grafting for up to 7 years, and it can be used to treat patients requiring dental implantation.

目的:评价基于磷酸八钙和编码血管内皮生长因子的质粒DNA基因激活骨替代物在牙种植体植骨中的长期临床效果。材料与方法:本临床研究从2017年启动的注册临床试验开始,对100例采用基因激活骨替代物植骨治疗牙槽嵴萎缩及颌骨获得性骨缺损患者的长期治疗效果进行分析。所有入组患者均在标准手术(鼻窦提升、引导骨增强、膀胱切除术等)中使用基因激活骨替代物对上颌骨或下颌进行植骨。采用临床方法和CT (computer tomography, CT),对植骨后6个月~ 7年不同时间点的延迟临床观察结果进行评估,并对环甲活检标本进行组织学分析。结果:所有患者术后6个月内植骨区均有新生骨密度组织。随访7年,密度保持在较高水平。新形成组织的体积保持在最小的吸收:体积减少12±5.9%。组织学上,在环甲活检标本中发现新形成的骨组织和部分吸收的骨替代物碎片。结论:基因激活骨替代物在颌骨移植中具有长达7年的安全性和长期有效性,可用于需要种植牙的患者。
{"title":"[Alveolar ridge bone augmentation using gene-activated bone substitute: long-term clinical follow-up].","authors":"I Y Bozo, A Y Drobyshev, N A Redko, G A Volozhin, E V Presnyakov, R V Deev","doi":"10.17116/stomat202510406256","DOIUrl":"https://doi.org/10.17116/stomat202510406256","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the long-term clinical results of the gene-activated bone substitute based on octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor in bone grafting for dental implantation.</p><p><strong>Materials and methods: </strong>This clinical study analyzed the long-term treatment results of 100 patients with alveolar ridge atrophy and acquired bone defects of the jaws who underwent bone grafting with gene-activated bone substitute, starting with registration clinical trials initiated in 2017. All patients enrolled in the study underwent bone grafting of the upper or lower jaws using the gene-activated bone substitute in standard surgeries (sinus lifting, guided bone augmentation, cystectomy, etc.). The results of delayed clinical observation were assessed at different time points from 6 months to 7 years after bone grafting using clinical methods and computed tomography (CT), as well as histological analysis of trephine biopsy specimens.</p><p><strong>Results: </strong>Newly formed tissues of bone density were detected in the bone grafting area in all patients within 6 months after surgery. The density remained at a high level during 7 years of follow-up. The volume of the newly formed tissues was maintained with minimal resorption: the decrease in volume was 12±5.9%. Histologically, newly-formed bone tissue with partially resorbed bone substitute fragments were indentified in trephine biopsy specimens.</p><p><strong>Conclusion: </strong>Thus, the gene-activated bone substitute has proven its safety and long-term effectiveness in jaw bone grafting for up to 7 years, and it can be used to treat patients requiring dental implantation.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"104 6. Vyp. 2","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current state of the issue of using surgical templates for dental implantation in the treatment of patients with missing teeth]. [在治疗缺牙患者中使用外科模板种植牙的现状]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510406160
F F Losev, T V Brailovskaya, A F Sarganov

Modern technologies in implantology can significantly improve the accuracy and safety of surgical interventions. The use of MSCT and CBCT provides a detailed assessment of anatomical structures, while CBCT has a lower radiation load. Digital modeling of dental arches is carried out using intraoral scanners or digitization of plaster models, which achieves high accuracy and allows for the creation of effective orthopedic structures. 3D printing and milling from various materials, such as PMMA or polylactic acid, are used to manufacture surgical templates, which ensures their stability and compliance with the patient's anatomy. The use of radiopaque materials improves the visualization of templates in images, and the combination of CT data and optical models allows for accurate planning of the location of implants. The introduction of these technologies contributes to more accurate installation of dental implants, reducing risks and achieving optimal aesthetic and functional results.

现代种植技术可以显著提高手术干预的准确性和安全性。MSCT和CBCT的使用提供了详细的解剖结构评估,而CBCT具有较低的辐射负荷。使用口腔内扫描仪或数字化石膏模型进行牙弓的数字化建模,从而实现高精度并允许创建有效的矫形结构。3D打印和铣制各种材料,如PMMA或聚乳酸,用于制造手术模板,这确保了它们的稳定性和符合患者的解剖结构。不透射线材料的使用提高了图像中模板的可视化,CT数据和光学模型的结合可以精确规划植入物的位置。这些技术的引入有助于更准确地安装牙科植入物,降低风险,实现最佳的美学和功能效果。
{"title":"[Current state of the issue of using surgical templates for dental implantation in the treatment of patients with missing teeth].","authors":"F F Losev, T V Brailovskaya, A F Sarganov","doi":"10.17116/stomat202510406160","DOIUrl":"10.17116/stomat202510406160","url":null,"abstract":"<p><p>Modern technologies in implantology can significantly improve the accuracy and safety of surgical interventions. The use of MSCT and CBCT provides a detailed assessment of anatomical structures, while CBCT has a lower radiation load. Digital modeling of dental arches is carried out using intraoral scanners or digitization of plaster models, which achieves high accuracy and allows for the creation of effective orthopedic structures. 3D printing and milling from various materials, such as PMMA or polylactic acid, are used to manufacture surgical templates, which ensures their stability and compliance with the patient's anatomy. The use of radiopaque materials improves the visualization of templates in images, and the combination of CT data and optical models allows for accurate planning of the location of implants. The introduction of these technologies contributes to more accurate installation of dental implants, reducing risks and achieving optimal aesthetic and functional results.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"104 6","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evolutionary trends in the evolution of the microelemental composition of enamel, surface layers of dentin, cement of human teeth in the North-Western region of Siberia in the X-XX centuries]. [X-XX世纪西伯利亚西北部地区牙釉质、牙本质表层、牙水泥的微量元素组成演变趋势]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat20251040115
Yu A Dombrovskaya, O N Kravets, A V Nikolaeva, M I Kotov, V I Dombrovskaya, K A Benken, A V Silin

The aim of the study: To study the trace element composition of various areas of hard tooth tissues in caries, pathological attrition and periodontal diseases on the archaeological material of dental remains of the X-XX centuries.

Materials and methods: The microelement composition of hard dental tissues of X-XX centuries' teeth was analyzed using the TM 3000 electronic microanalyzer (Hitachi, Japan).

Results: The patterns of microelement composition in diseases of hard dental tissues and periodontal disease have been revealed. The results of two-factor analysis of variance confirmed a statistically significant dependence of the average values of O and C content in enamel over the centuries (p<0.0001), the average values of P, Zn, O and Mg in dentin (p<0.0001), the average values of O and C content in cement (p<0.0001). High correlation between Ca and Sr in enamel (Pearson's r=0.847; t-criterion=7.98; statistical significance p<0.01; n=27) and a noticeable correlation in dentin (Pearson's r=0.512; t-criterion=2.46; p<0.05).

Conclusion: The results indicate that with the relative constancy of anatomical and morphological characteristics, the variability of the mineral composition is observed, as well as its pronounced dependence on exogenous factors.

研究目的:研究X-XX世纪牙齿遗骸考古材料中龋病、病理性磨损和牙周病硬牙组织各区域微量元素组成。材料与方法:采用日本日立TM 3000型电子微量分析仪对X-XX世纪牙齿硬牙组织进行微量元素分析。结果:揭示了牙硬组织疾病和牙周病中微量元素组成的规律。双因素方差分析结果证实,各世纪间牙釉质中O和C含量平均值的相关性具有统计学意义(pppr=0.847;t-criterion = 7.98;统计学意义pn=27),牙本质相关性显著(Pearson’s r=0.512;t-criterion = 2.46;结论:在解剖形态特征相对稳定的情况下,其矿物组成具有一定的变异性,且对外源因素有明显的依赖性。
{"title":"[Evolutionary trends in the evolution of the microelemental composition of enamel, surface layers of dentin, cement of human teeth in the North-Western region of Siberia in the X-XX centuries].","authors":"Yu A Dombrovskaya, O N Kravets, A V Nikolaeva, M I Kotov, V I Dombrovskaya, K A Benken, A V Silin","doi":"10.17116/stomat20251040115","DOIUrl":"10.17116/stomat20251040115","url":null,"abstract":"<p><strong>The aim of the study: </strong>To study the trace element composition of various areas of hard tooth tissues in caries, pathological attrition and periodontal diseases on the archaeological material of dental remains of the X-XX centuries.</p><p><strong>Materials and methods: </strong>The microelement composition of hard dental tissues of X-XX centuries' teeth was analyzed using the TM 3000 electronic microanalyzer (Hitachi, Japan).</p><p><strong>Results: </strong>The patterns of microelement composition in diseases of hard dental tissues and periodontal disease have been revealed. The results of two-factor analysis of variance confirmed a statistically significant dependence of the average values of O and C content in enamel over the centuries (<i>p</i><0.0001), the average values of P, Zn, O and Mg in dentin (<i>p</i><0.0001), the average values of O and C content in cement (<i>p</i><0.0001). High correlation between Ca and Sr in enamel (Pearson's <i>r</i>=0.847; <i>t</i>-criterion=7.98; statistical significance <i>p</i><0.01; <i>n</i>=27) and a noticeable correlation in dentin (Pearson's <i>r</i>=0.512; <i>t</i>-criterion=2.46; <i>p</i><0.05).</p><p><strong>Conclusion: </strong>The results indicate that with the relative constancy of anatomical and morphological characteristics, the variability of the mineral composition is observed, as well as its pronounced dependence on exogenous factors.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"104 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical manifestation, surgical treatment and post-surgical rehabilitation with novel wound dressing of patient with Madelung's disease]. 【新型创面敷料的临床表现、手术治疗及术后康复】。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/stomat202510403183
Z Yu Visaitova, T Z Chkadua, E V Azarenkov, Kh M Ibragimova

The paper presents a clinical case of a 55-year-old patient with a diagnosis of extensive lipomatosis of the right and left occipital, parotid-masticatory areas, submandibular area, neck areas on all sides, supra-scapular area; Madelung's disease. The first stage of reconstructive surgery was performed. During the healing period, highly absorbent dressings were used to control the level of wound exudate, which prevents over-wetting of the wound and promotes better healing.

本文报告一个55岁的临床病例,诊断为左右枕部,腮腺-咀嚼区,下颌下区,颈部各侧,肩胛上区广泛的脂肪瘤病;马德隆能的疾病。进行了第一阶段的重建手术。在愈合期间,使用高吸收性敷料来控制伤口渗出物的水平,防止伤口过度湿润,促进愈合。
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Stomatologiya
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