Pub Date : 2023-06-30DOI: 10.17966/jmi.2023.28.2.23
Hyun-Min Seo, Sungyu Kim, Y. Huh, S. Oh, J. Kim
Dermatophytosis is a fungal infection of the keratinized tissues of the skin, hair, and nails caused by dermatophytes or other fungi. Epidermophyton, Microsporum, and Trichophyton are the three genera of dermatophytes that cause skin infections. In Korea, Trichophyton rubrum is the most common dermatophytes. Dermatophytosis can be classified into anthropophilic, zoophilic, and geophilic, and most fungal infections encountered by dermatologists are tinea, dermatophytosis. This study attempted to provide a brief discussion about the clinical manifestation, diagnosis, and considerations for antifungal use in the treatment of dermatophytosis.
{"title":"Dermatophytosis: Clinical Manifestation, Diagnosis,\u0000and Considerations for Antifungal use","authors":"Hyun-Min Seo, Sungyu Kim, Y. Huh, S. Oh, J. Kim","doi":"10.17966/jmi.2023.28.2.23","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.2.23","url":null,"abstract":"Dermatophytosis is a fungal infection of the keratinized tissues of the skin, hair, and nails caused by dermatophytes or other fungi. Epidermophyton, Microsporum, and Trichophyton are the three genera of dermatophytes that cause skin infections. In Korea, Trichophyton rubrum is the most common dermatophytes. Dermatophytosis can be classified into anthropophilic, zoophilic, and geophilic, and most fungal infections encountered by dermatologists are tinea, dermatophytosis. This study attempted to provide a brief discussion about the clinical manifestation, diagnosis, and considerations for antifungal use in the treatment of dermatophytosis.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44445175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A connection was reported between hepatitis C virus (HCV) and chronic kidney disease (CKD). A viral infection can be both a cause and a consequence of CKD. HCV infection is associated with a greater incidence of diabetes mellitus and CKD and a higher risk of systemic (particularly cardiovascular) effects because HCV infection increases the chance of illness developing. Although the fundamental symptom of HCV-induced glomerulonephritis has been well documented, the virus has been related to CKD in various ways, i.e., new evidence points to a connection between HCV infection and CKD onset, as well as the rapid advancement of CKD to end-stage renal disease, which calls for kidney transplantation or hemodialysis. An HCV infection dramatically increased a person's risk of developing CKD, which can lead to kidney failure. Compared with patients with HCV infection and existing CKD, those with HCV infection who had normal renal function had greater odds of renal progression. The administration of anti-hepatitis medication can result in variations in the estimated glomerular filtration rate, which can either lead to an improvement or a worsening of the patient's health, depending on which direction the variation goes.
{"title":"Hepatitis C Infection and Chronic Renal Diseases:\u0000A Systematic Review","authors":"Tara Titian Maulidya, Fauzio Nurul Khaira, Febi Ramdhani Rachman, Reynold Harris Malingkas","doi":"10.17966/jmi.2023.28.2.28","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.2.28","url":null,"abstract":"A connection was reported between hepatitis C virus (HCV) and chronic kidney disease (CKD). A viral infection can be both a cause and a consequence of CKD. HCV infection is associated with a greater incidence of diabetes mellitus and CKD and a higher risk of systemic (particularly cardiovascular) effects because HCV infection increases the chance of illness developing. Although the fundamental symptom of HCV-induced glomerulonephritis has been well documented, the virus has been related to CKD in various ways, i.e., new evidence points to a connection between HCV infection and CKD onset, as well as the rapid advancement of CKD to end-stage renal disease, which calls for kidney transplantation or hemodialysis. An HCV infection dramatically increased a person's risk of developing CKD, which can lead to kidney failure. Compared with patients with HCV infection and existing CKD, those with HCV infection who had normal renal function had greater odds of renal progression. The administration of anti-hepatitis medication can result in variations in the estimated glomerular filtration rate, which can either lead to an improvement or a worsening of the patient's health, depending on which direction the variation goes.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43435250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.16
J. Seol, Sang-Woo Ahn, Seung Hee Jang, Hyojin Kim
{"title":"A Case of Extensive Lichen Planus on Both Extremities\u0000Following mRNA-1273 Vaccination","authors":"J. Seol, Sang-Woo Ahn, Seung Hee Jang, Hyojin Kim","doi":"10.17966/jmi.2023.28.1.16","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.16","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48377164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.10
Dong-Wha Yoo, Kyung-Deok Park, H. Kwon, Jeong-Wan Seo, J. Yoon, Ki-Ho Kim
Oral candidiasis, a common fungal infection in humans, is characterized by the overgrowth of Candida species in the superficial oral epithelial mucosa. The condition is associated with multiple risk factors, including impaired salivary gland function, oral mucosal damage, and long-term antibiotic or corticosteroid use. Several treatment options are available; nystatin and amphotericin B are the most widely used local medications. Recently, fluconazole has emerged as the preferred systemic treatment. We report a case of oral candidiasis in an 83-year-old male diagnosed with bullous pemphigoid in 2017 and previously administered methylprednisolone. He developed oral candidiasis a few months before presentation and was treated with 10 mL nystatin suspension three times daily; unfortunately, the disease was recalcitrant to this treatment and his symptoms showed no improvement over two months. We discontinued nystatin in favor of fluconazole syrup (Diflucan®) administered by rinsing, then swallowing, 5 mL syrup once daily. The lesion improved after one month of treatment. This case demonstrates the efficacy of fluconazole as a primary treatment for oral candidiasis. The act of rinsing the mouth with syrup exposes the oral mucosa to drug, potentially producing a better treatment response than taking the syrup orally without rinsing.
{"title":"A Case of Oral Candidiasis Treated with\u0000Fluconazole (Diflucan®) Mouthrinse","authors":"Dong-Wha Yoo, Kyung-Deok Park, H. Kwon, Jeong-Wan Seo, J. Yoon, Ki-Ho Kim","doi":"10.17966/jmi.2023.28.1.10","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.10","url":null,"abstract":"Oral candidiasis, a common fungal infection in humans, is characterized by the overgrowth of Candida species in the superficial oral epithelial mucosa. The condition is associated with multiple risk factors, including impaired salivary gland function, oral mucosal damage, and long-term antibiotic or corticosteroid use. Several treatment\u0000options are available; nystatin and amphotericin B are the most widely used local medications. Recently, fluconazole has emerged as the preferred systemic treatment. We report a case of oral candidiasis in an 83-year-old male diagnosed with bullous pemphigoid in 2017 and previously administered methylprednisolone. He developed oral\u0000candidiasis a few months before presentation and was treated with 10 mL nystatin suspension three times daily; unfortunately, the disease was recalcitrant to this treatment and his symptoms showed no improvement over two months. We discontinued nystatin in favor of fluconazole syrup (Diflucan®) administered by rinsing, then swallowing, 5 mL syrup once daily. The lesion improved after one month of treatment. This case demonstrates the efficacy of fluconazole as a primary treatment for oral candidiasis. The act of rinsing the mouth with syrup exposes the oral\u0000mucosa to drug, potentially producing a better treatment response than taking the syrup orally without rinsing.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49660729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.21
Sang-Kyung Lee, Han-Nah Park, Yeon-Soo Kim, Jin Park
{"title":"Dermoscopic and Electron Microscopic Findings of\u0000Black dot Tinea Capitis by Trichophyton tonsurans","authors":"Sang-Kyung Lee, Han-Nah Park, Yeon-Soo Kim, Jin Park","doi":"10.17966/jmi.2023.28.1.21","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.21","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45493096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.14
Jin Seon Bang, Y. Jang
{"title":"Clinical Examination of Stenotrophomonas maltophilia\u0000Infection in Patient with Pyoderma Gangrenosum","authors":"Jin Seon Bang, Y. Jang","doi":"10.17966/jmi.2023.28.1.14","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.14","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48328613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.19
Jisoo Kim, Jisung Kim, T. Kim, Joonsoo Park
{"title":"Plate Medium Findings of Trichophyton mentagrophytes","authors":"Jisoo Kim, Jisung Kim, T. Kim, Joonsoo Park","doi":"10.17966/jmi.2023.28.1.19","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.19","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49587417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.17966/jmi.2023.28.1.1
Sang-Doo Lee, M. Shin
Background: Oral antifungal drugs are the primary treatment for onychomycosis. However, there are few studies on the effectiveness and safety of oral combination therapy after laser treatment. Objective: We sought to contrast the efficacy and safety of laser and oral combination therapy with that of oral monotherapy for non-responders to laser treatment. Methods: We retrospectively evaluated the medical charts and photographs of 20 patients who received four sessions of Nd:YAG laser. Among these patients, 11 were "laser non-responders" and 9 were "laser partial responders". Afterward, 10 patients received oral drugs in addition to laser treatment (combination therapy) and the other 10 were completely altered to oral drugs, with no laser treatment (oral monotherapy). Clinical evaluation was conducted at baseline and 3 months after treatment. Recurrence was evaluated 3 months after the final evaluation. Results: Clinical evaluation revealed that combining or switching to oral antifungal drugs was substantially effective in the laser non-responder group (Z = -2.481, p = 0.013). Combination therapy was more effective than oral monotherapy (Z = -1.324, p = 0.247). Furthermore, positive baseline mycological results demonstrated a higher possibility of laser monotherapy failure (χ2 = -5.089, p = 0.024). There were two cases of recurrence in the oral monotherapy group and no adverse effect was discovered in any patient. Conclusion: This study highlighted that the combination of oral drugs with laser therapy could be beneficial regarding efficacy, recurrence, and safety in the treatment of patients who are refractory to laser therapy.
背景:口服抗真菌药物是治疗甲真菌病的主要方法。然而，关于激光治疗后口服联合治疗的有效性和安全性的研究很少。目的:比较激光与口服联合治疗与口服单药治疗对激光治疗无反应的疗效和安全性。方法:回顾性分析20例接受4次Nd:YAG激光治疗的患者的病历和照片。其中11例为激光无反应者，9例为激光部分反应者。随后，10例患者在激光治疗的基础上口服药物(联合治疗)，另外10例完全改为口服药物，不进行激光治疗(口服单药治疗)。分别于治疗前和治疗后3个月进行临床评价。在最终评估后3个月评估复发情况。结果:临床评价显示，激光无反应组联合或改用口服抗真菌药物基本有效(Z = -2.481, p = 0.013)。联合治疗优于口服单药治疗(Z = -1.324, p = 0.247)。此外，阳性的基线真菌学结果表明激光单药治疗失败的可能性更高(χ2 = -5.089, p = 0.024)。口服单药治疗组复发2例，无不良反应发生。结论:本研究强调了口服药物与激光治疗联合治疗对激光治疗难治性患者在疗效、复发和安全性方面是有益的。
{"title":"Retrospective Study of the Efficacy and Safety of Laser\u0000and Oral Combination Therapy for Non-responders to\u0000Neodymium-doped Yttrium Aluminum Garnet Laser:\u0000A Review of 20 Patients with Onychomycosis","authors":"Sang-Doo Lee, M. Shin","doi":"10.17966/jmi.2023.28.1.1","DOIUrl":"https://doi.org/10.17966/jmi.2023.28.1.1","url":null,"abstract":"Background: Oral antifungal drugs are the primary treatment for onychomycosis. However, there are few studies on the effectiveness and safety of oral combination therapy after laser treatment.\u0000Objective: We sought to contrast the efficacy and safety of laser and oral combination therapy with that of oral monotherapy for non-responders to laser treatment.\u0000Methods: We retrospectively evaluated the medical charts and photographs of 20 patients who received four sessions of Nd:YAG laser. Among these patients, 11 were \"laser non-responders\" and 9 were \"laser partial responders\". Afterward, 10 patients received oral drugs in addition to laser treatment (combination therapy) and the other 10 were completely altered to oral drugs, with no laser treatment (oral monotherapy). Clinical evaluation was conducted at baseline and 3 months after treatment. Recurrence was evaluated 3 months after the final evaluation.\u0000Results: Clinical evaluation revealed that combining or switching to oral antifungal drugs was substantially effective in the laser non-responder group (Z = -2.481, p = 0.013). Combination therapy was more effective than oral monotherapy (Z = -1.324, p = 0.247). Furthermore, positive baseline mycological results demonstrated a higher\u0000possibility of laser monotherapy failure (χ2 = -5.089, p = 0.024). There were two cases of recurrence in the oral monotherapy group and no adverse effect was discovered in any patient.\u0000Conclusion: This study highlighted that the combination of oral drugs with laser therapy could be beneficial\u0000regarding efficacy, recurrence, and safety in the treatment of patients who are refractory to laser therapy.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45717130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.17966/jmi.2022.27.4.85
J. Seol, S. Hong, Seung Hee Jang, Sang-Woo Ahn, J. Choi, J. Shin, Jayoung Kim, Hyojin Kim
Dermatophytes invade the stratum corneum and infect the skin, nails, and hair, mostly resulting in superficial infections. Deep dermatophytosis involving the dermis and subcutaneous layer has rarely been reported in immunocompromised individuals. Herein, we report a case of deep dermatophytosis caused by Trichophyton rubrum. A 71-year-old woman presented with multiple erythematous exophytic and subcutaneous nodules in both the lower legs. The patient was taking immunosuppressive agents for rheumatoid arthritis and antifungal agents for tinea pedis and onychomycosis, which was improperly ceased. Histopathological findings showed diffuse granulomatous infiltration with multinucleated cells, lymphocytes, histiocytes, and neutrophils in the dermis. Septate and branched hyphae were observed in the dermis using periodic acid-Schiff diastase and Gomori methenamine silver staining. T. rubrum was identified in fungal culture from the tissue sample and confirmed through phylogenetic analysis of the internal transcribed spacer and large subunit regions in ribosomal ribonucleic acid gene. Intravenous amphotericin B was administered for septic shock before the confirmation of the causative organism, which rapidly improved the condition.
{"title":"Deep Dermatophytosis Presented as Multiple Exophytic Masses caused by Trichophyton rubrum in Immunocompromised Patient with Rheumatoid Arthritis; A Case Report","authors":"J. Seol, S. Hong, Seung Hee Jang, Sang-Woo Ahn, J. Choi, J. Shin, Jayoung Kim, Hyojin Kim","doi":"10.17966/jmi.2022.27.4.85","DOIUrl":"https://doi.org/10.17966/jmi.2022.27.4.85","url":null,"abstract":"Dermatophytes invade the stratum corneum and infect the skin, nails, and hair, mostly resulting in superficial infections. Deep dermatophytosis involving the dermis and subcutaneous layer has rarely been reported in immunocompromised individuals. Herein, we report a case of deep dermatophytosis caused by Trichophyton rubrum. A 71-year-old woman presented with multiple erythematous exophytic and subcutaneous nodules in both the lower legs. The patient was taking immunosuppressive agents for rheumatoid arthritis and antifungal agents for tinea pedis and onychomycosis, which was improperly ceased. Histopathological findings showed diffuse granulomatous infiltration with multinucleated cells, lymphocytes, histiocytes, and neutrophils in the dermis. Septate and branched hyphae were observed in the dermis using periodic acid-Schiff diastase and Gomori methenamine silver staining. T. rubrum was identified in fungal culture from the tissue sample and confirmed through phylogenetic analysis of the internal transcribed spacer and large subunit regions in ribosomal ribonucleic acid gene. Intravenous amphotericin B was administered for septic shock before the confirmation of the causative organism, which rapidly improved the condition.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42666961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.17966/jmi.2022.27.4.63
Sangbin Jeong, Seungjong Kim, M. Suh, K. Lee
Background: Few studies have been reported on facial herpes zoster and the risk factors for its complications. Objective: This study aimed to investigate the clinical features and risk factors with facial herpes zoster. Methods: We examined the medical records of 676 patients with facial herpes zoster during a 10-year-period from 2011 to 2020. We assessed the proportion of ocular complications, Ramsay-Hunt syndrome, and postherpetic neuralgia in patients with facial herpes zoster according to several clinical factors including age, sex, dermatomes, underlying disease, and time to initiate antiviral treatment. Results: The incidence of ocular complications was significantly higher in males (Odds ratia [OR], 2.59; 95% CI, 1.26~5.32), and with involvement of ophthalmic branches of the trigeminal nerve (V1: OR, 14.28; 95% CI, 3.62~56.29; V1 inclusion: OR, 20.68; 95% CI, 7.99~53.55), underlying diseases (OR, 1.70; 95% CI, 1.08~2.68) and positive Hutchinson's sign (OR, 3.59; 95% CI, 1.72~7.49). Ramsay-Hunt syndrome was significantly correlated with involvement of VII dermatome (OR, 24.68; 95% CI, 2.97~204.75), and showed considerable significant with otalgia (OR, 3.31; 95% CI 0.98~11.22). Postherpetic neuralgia was significantly higher in those over 60 years of age (OR, 2.03; 95% CI, 1.48~2.78), ocular complications (OR, 2.28; 95% CI, 1.57~3.30), and ear involvement (OR 1.94; 95% CI 1.17~3.20). Conclusion: These results demonstrated that facial herpes zoster was associated with ocular complications, Ramsay-Hunt syndrome, and postherpetic neuralgia. The incidence of these complications was related to risk factors such as sex, age, dermatome, underlying disease, Hutchinson's sign and otalgia. To decrease the risk of complications associated with facial herpes zoster, patients should receive appropriate antiviral therapy and interdepartmental consultations immediately.
{"title":"Clinical Features and Risk Factors for Complications of\u0000Facial Herpes Zoster in Inpatients","authors":"Sangbin Jeong, Seungjong Kim, M. Suh, K. Lee","doi":"10.17966/jmi.2022.27.4.63","DOIUrl":"https://doi.org/10.17966/jmi.2022.27.4.63","url":null,"abstract":"Background: Few studies have been reported on facial herpes zoster and the risk factors for its complications.\u0000Objective: This study aimed to investigate the clinical features and risk factors with facial herpes zoster.\u0000Methods: We examined the medical records of 676 patients with facial herpes zoster during a 10-year-period from 2011 to 2020. We assessed the proportion of ocular complications, Ramsay-Hunt syndrome, and postherpetic neuralgia in patients with facial herpes zoster according to several clinical factors including age, sex, dermatomes, underlying disease, and time to initiate antiviral treatment.\u0000Results: The incidence of ocular complications was significantly higher in males (Odds ratia [OR], 2.59; 95% CI, 1.26~5.32), and with involvement of ophthalmic branches of the trigeminal nerve (V1: OR, 14.28; 95% CI, 3.62~56.29; V1 inclusion: OR, 20.68; 95% CI, 7.99~53.55), underlying diseases (OR, 1.70; 95% CI, 1.08~2.68) and positive Hutchinson's sign (OR, 3.59; 95% CI, 1.72~7.49). Ramsay-Hunt syndrome was significantly correlated\u0000with involvement of VII dermatome (OR, 24.68; 95% CI, 2.97~204.75), and showed considerable significant with otalgia (OR, 3.31; 95% CI 0.98~11.22). Postherpetic neuralgia was significantly higher in those over 60 years of age (OR, 2.03; 95% CI, 1.48~2.78), ocular complications (OR, 2.28; 95% CI, 1.57~3.30), and ear involvement (OR\u00001.94; 95% CI 1.17~3.20).\u0000Conclusion: These results demonstrated that facial herpes zoster was associated with ocular complications, Ramsay-Hunt syndrome, and postherpetic neuralgia. The incidence of these complications was related to risk factors such as sex, age, dermatome, underlying disease, Hutchinson's sign and otalgia. To decrease the risk of complications associated with facial herpes zoster, patients should receive appropriate antiviral therapy and interdepartmental consultations immediately.","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48865374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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