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A Multicenter Study of Antifungal Use and Species Distribution and Antifungal usceptibilities of Candida Isolates in South Korea 韩国念珠菌的抗真菌使用、种类分布和抗真菌敏感性的多中心研究
Q4 Medicine Pub Date : 2020-03-31 DOI: 10.17966/jmi.2020.25.1.10
J. Shin, E. Won, S. Kim, Jongcheol Shin, Dain Lee, Dong Hyun Lee, Y. A. Kim, Jongyoun Yi, J. Shin, K. Shin, S. Jeong
Background: Candidiasis control should include monitoring the epidemiology and resistance to various antifungal agents. In this study, the researchers investigated the Candida species recovered from clinical specimens at particular geographic areas or hospitals.Objective: The present study is geared toward the evaluation of antifungal drug usage at Korean hospitals in 2016. It is also essential that species distribution and antifungal susceptibilities of Candida isolates should be looked into to provide important data that can help devise therapeutic strategies to control the disease.Methods: Systemic antifungal agent usage over a one-year period was investigated at 10 Korean hospitals. Identification and antifungal susceptibility tests were performed on clinical isolates of the Candida species, which were collected over a three-month period.Results: The total antifungal usage in each hospital ranged from 7.7 to 158.9 defined daily doses (DDDs) per 1,000 patient days. Fluconazole was most commonly used (37.1%), followed by amphotericin B (30.6%), itraconazole (9.7%), echinocandins (8.8%), voriconazole (7.5%), and posaconazole (6.3%), respectively. Among 274 Candidaisolates, C. albicans was the most frequently recovered (51.1%), followed by C. glabrata (15.7%), C. tropicalis (15.0%), and C. parapsilosis (13.5%), respectively. Through the application of either species-specific clinical breakpoints or epidemiological cutoff values to Candida isolates, the non-susceptibility rates to fluconazole, voriconazole, amphotericin B, and micafungin were found in 20.7%, 5.6%, 0%, and 0% of isolates, respectively.Conclusion: This nationwide multicenter study showed that total antifungal use varied considerably according to each hospital. Non-susceptibility to fluconazole should be further monitored, considering the drug's frequent use in Korea.
背景:念珠菌感染的控制应包括监测流行病学和对各种抗真菌药物的耐药性。在这项研究中,研究人员调查了在特定地理区域或医院从临床标本中回收的念珠菌。目的:本研究旨在评估2016年韩国医院抗真菌药物的使用情况。同样重要的是,应研究念珠菌分离株的物种分布和抗真菌易感性,以提供重要数据,帮助制定控制疾病的治疗策略。方法:对韩国10家医院一年来的系统抗真菌药物使用情况进行调查。对念珠菌的临床分离株进行了鉴定和抗真菌药敏试验,这些分离株是在三个月内收集的。结果:每家医院的抗真菌药物使用总量为每1000个患者日7.7至158.9个限定日剂量(DDDs)。氟康唑最常用(37.1%),其次是两性霉素B(30.6%)、伊曲康唑(9.7%)、棘白菌素(8.8%)、伏立康唑(7.5%)和泊沙康唑(6.3%)。在274种念珠菌中,白色念珠菌的回收率最高(51.1%),其次是光滑念珠菌(15.7%)、热带念珠菌(15.0%)和近裸念珠菌(13.5%)。通过对念珠菌分离株应用物种特异性临床断点或流行病学临界值,发现对氟康唑、伏立康唑、两性霉素B和米卡芬净的不敏感率分别为20.7%、5.6%、0%和0%。结论:这项全国性的多中心研究表明,各医院的抗真菌总使用量差异很大。考虑到氟康唑在韩国的频繁使用,应进一步监测其对氟康唑的不敏感性。
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引用次数: 1
Efficient Utilization of Korean Medical Fungal Pathogen Resource Bank for Clinical Research 高效利用韩国药用真菌病原体资源库进行临床研究
Q4 Medicine Pub Date : 2019-09-30 DOI: 10.17966/jmi.2019.24.3.69
Jayoung Kim, Junsang Oh, G. Sung, Hyeyoung Lee, J. Choi, Sangheun Lee, Minbum Kim, S. Choi
A "pathogen resource" contains information about pathogens (e.g., bacteria, fungi, viruses, and protozoa) and microbial derivatives (e.g., DNA, RNA, plasmid, clone, and cDNA). Pathogen resources are important for their potential use in healthcare research because they contain clinical and epidemiological information that is different from microbial resources. In October 2014, the "Nagoya Protocol" on access and benefit-sharing with the Convention on Biological Diversity was enacted to restrict the movement of transboundary pathogens and protect the natural pathogen resources of each country. On July 2017, the Korean Medical Fungal Pathogen Resource Bank (KMFRB) was established to secure, discover, and develop biological resources focused on medical fungi. KMFRB has since been operating under the National Culture Collection for Pathogens of the National Institute of Health based on the Act No. 13992. This report aims to provide general information regarding KMFRB and suggest efficient ways to utilize human fungal pathogen resources for clinical research.
“病原体资源”包含有关病原体(如细菌、真菌、病毒和原生动物)和微生物衍生物(如DNA、RNA、质粒、克隆和cDNA)的信息。病原体资源在卫生保健研究中的潜在用途是重要的,因为它们包含不同于微生物资源的临床和流行病学信息。2014年10月,通过了《生物多样性公约》关于获取和惠益分享的“名古屋议定书”,以限制跨界病原体的流动,保护各国的自然病原体资源。韩国医用真菌病原资源库(KMFRB)于2017年7月成立,旨在确保、发现和开发以医用真菌为重点的生物资源。此后,该研究所一直根据第13992号法在国家卫生研究所的国家病原体培养库下运作。本报告旨在提供有关KMFRB的一般信息,并提出有效利用人类真菌病原体资源进行临床研究的方法。
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引用次数: 0
Epidemiological and Mycological Characteristics of Teenagers with Tinea Capitis in Southeastern Korea: Trichophyton tonsurans as the Main Causative Fungus in Recent 10 Years 韩国东南部青少年头癣的流行病学和真菌学特征:近10年来以癣毛癣菌为主要病原菌
Q4 Medicine Pub Date : 2019-09-30 DOI: 10.17966/jmi.2019.24.3.79
C. Sohng, J. Kim, K. Park, Y. Jang, Seok-Jong Lee, Y. Bang, J. Jun, W. Lee
Background: Tinea capitis is a contagious fungal infection that occurs predominantly in childhood. Although its incidence has declined, its epidemiological and mycological characteristics are continue to evolve.Objective: To assess changes in the epidemiological and mycological characteristics of tinea capitis in teenage patients in Southeastern Korea.Methods: We retrospectively investigated epidemiological and mycological characteristics of 202 teenage patientswith tinea capitis who visited Kyungpook National University Hospital and the Catholic Skin Disease Clinic from1989-2018.Results: Of 202 patients, 177 patients showed KOH-positivity. Dermatophytes were cultured from 157 patients. The annual incidence of tinea capitis ranged from 0 to 30 between 1989 and 2018. Of 202 patients, 153 patients (75.74%) were male and 49 patients (24.26%) were female. The ratio of male to female was 1:0.32. For seasonal distribution, 78 patients (38.61%) visited our hospital in winter, 59 patients (29.21%) visited in spring, 35 patients (17.33%) visited in fall, and 30 patients (14.85%) visited in summer. Microsporum canis was the most common dermatophyte (44.06%) isolated from tinea capitis. Trichophyton tonsurans was the second most common dermatophyte (26.73%). For inhabitancy distribution, 151 patients (74.75%) lived in urban areas and 51 (25.25%) lived in rural areas.Conclusion: The epidemiological characteristics of teenage patients with tinea capitis were distinct from those of adults in annual incidence, sexual distribution and isolated dermatophytes. Trichophyton tonsurans was the main causative organism of tinea capitis in recent 10 years. These results are useful for the targeted treatment and prevention of tinea capitis.
背景:头癣是一种主要发生在儿童期的传染性真菌感染。虽然发病率有所下降,但其流行病学和真菌学特征仍在继续演变。目的:了解韩国东南部青少年头癣患者的流行病学和真菌学特征的变化。方法:回顾性分析1989-2018年在庆北大学医院和天主教皮肤病诊所就诊的202例青少年头癣患者的流行病学和真菌学特征。结果:202例患者中koh阳性177例。从157例患者中培养皮肤真菌。1989年至2018年间,头癣的年发病率在0 - 30之间。202例患者中,男性153例(75.74%),女性49例(24.26%)。男女比例为1:0.32。季节分布方面,冬季就诊78例(38.61%),春季就诊59例(29.21%),秋季就诊35例(17.33%),夏季就诊30例(14.85%)。犬小孢子菌是头癣中最常见的皮菌(44.06%)。第二常见的是毛癣菌(26.73%)。从居住分布来看,151例(74.75%)患者生活在城市地区,51例(25.25%)患者生活在农村地区。结论:青少年头癣患者的流行病学特征在年发病率、性别分布和分离性皮癣菌等方面与成人不同。毛发毛癣菌是近10年来头癣的主要病原菌。这些结果对针对性的治疗和预防头癣是有用的。
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引用次数: 1
Fungal Melanonychia Caused by Cladosporium Species: A Case Report 枝孢菌引起真菌性黑甲病一例报告
Q4 Medicine Pub Date : 2019-09-30 DOI: 10.17966/jmi.2019.24.3.85
J. H. Yoon, M. An, E. Park, K. Kim, Kwang joong Kim
Fungal melanonychia is typically associated with onychomycosis and is known to be a relatively uncommon nail disorder. The known pathogens causing fungal melanonychia include both dematiaceous and non-dematiaceous fungi. Here we describe the case of a 60-year-old man with a 1-year history of nail discoloration in both index fingers.The possibility of subungual neoplasm was excluded by histological examination. Subsequent mycological examination revealed the presence of Cladosporium species in the lesion. The patient was successfully treated with oral itraconazole.
真菌性黑指甲病通常与甲真菌病有关,是一种相对罕见的指甲疾病。引起真菌性黑指甲炎的已知病原体包括暗色真菌和非暗色真菌。在这里,我们描述了一个60岁的男性病例,他有一年的食指指甲变色史。组织学检查排除了舌下肿瘤的可能性。随后的真菌学检查显示病变中存在枝孢菌。患者口服伊曲康唑治疗成功。
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引用次数: 0
Macroscopic Findings of Talaromyces scorteus 焦状Talaromyces的宏观发现
Q4 Medicine Pub Date : 2019-09-30 DOI: 10.17966/10.17966/jmi.2019.24.3.89
Jeongsoo Lee, Nuri Na, Joonsoo Park
There is no abstract
没有摘要
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引用次数: 0
Molecular Identification of Human Sporotrichosis in Korea 韩国人类孢子虫病的分子鉴定
Q4 Medicine Pub Date : 2019-06-30 DOI: 10.17966/JMI.2019.24.2.45
Hye Ri Kim, D. Shin, J. Lee, J. Choi
Background: Sporotrichosis is a common deep mycosis caused by the Sporothrix schenckii complex. Until 2016, no molecular studies had been conducted on these fungi, and all the included strains were reported as S. schenckii. However, investigations conducted in northeast China, Japan, and India revealed that S. globosa was the most prevalent Sporothrix species, whereas S. schenckii sensu stricto was reported very rarely. Objective: To investigate the accurate prevalent causative species of sporotrichosis among strains reported as S.schenckii in Korea. Methods: We isolated strains of Sporothrix spp. Prevalent in Korea from fungus collection centers or private collections and reviewed the available literature on molecular studies of strains from this region. We found five S. schenckii (1998-2016) and three S. globosa (2016-2018) strains. Ribosomal DNA internal transcribed spacer (ITS) sequences of these strains were compared with those of the S. schenckii complex strains. Results: The ribosomal ITS sequences of the eight strains were 100% identical with that of S. globose. No S. schenckii sensu stricto was found. In addition, a study on the molecular analysis of Korean S. schenckii published by Ishizaki et al. (2004) demonstrated that the eight strains were of the mitochondrial subtype group B (S. globosa). Thus, all the 16 strains examined within the Korean S. schenckii complex were determined to be S. globosa. Conclusion: In summary, S. globosa is the causative species within the tested Korean sporotrichosis cases reported between 1998 and 2018. Based on our analyses, S. globosa, and not S. schenckii, may be the predominant species in Korea.
背景:孢子丝菌病是由申克孢子丝复合体引起的一种常见的深部真菌病。直到2016年,还没有对这些真菌进行过分子研究,所有被纳入的菌株都被报道为申克酵母。然而,在中国东北部、日本和印度进行的调查显示,球形S.globosa是最普遍的孢子丝菌物种,而严格意义上的申克氏S.schenckii报道很少。目的:调查韩国申克克氏菌中孢子丝菌病的准确流行致病种。方法:我们从真菌采集中心或私人收藏中分离出在韩国流行的孢子丝菌菌株,并回顾了该地区菌株的分子研究文献。我们发现了5株申克氏链霉菌(1998-2016)和3株球状链霉菌(2016-2018)。将这些菌株的核糖体DNA内部转录间隔区(ITS)序列与申克氏酵母复合物菌株的序列进行了比较。结果:8株菌株的核糖体ITS序列与球形链霉菌的核糖体ITS完全一致。未发现严格意义上的申克氏杆菌。此外,Ishizaki等人(2004年)发表的一项关于韩国申克氏梭杆菌分子分析的研究表明,这八个菌株属于线粒体亚型B组(球形梭杆菌)。因此,在韩国申克氏链霉菌复合体中检测的所有16个菌株都被确定为球状链霉菌。结论:总之,球形S.globosa是1998年至2018年间报告的韩国孢子丝菌病病例中的致病种。根据我们的分析,球形S.globosa而不是申克氏S.schenckii可能是韩国的优势物种。
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引用次数: 2
A Case of Deep Cutaneous Purpureocillium lilacinum Fungal Infection in an Immunocompetent Patient 免疫功能正常患者深皮肤紫紫色纤毛菌真菌感染1例
Q4 Medicine Pub Date : 2019-06-30 DOI: 10.17966/JMI.2019.24.2.52
Hyojin Kim, Gyeong Je Cho, Jong Uk Kim, W. Jin, S. Park, S. Moon, J. Seol, J. Shin
Purpureocillium is a genus of saprophytic fungi that is commonly found in soil or rotting material. Although rarely a pathogen in humans, it can cause serious infections in immunocompromized patients. An 85-year-old woman presented with a 2-week history of pruritic erythematous plaques with yellowish crusts on her right forearm and dorsal hand. Histopathological analysis identified fungal hyphae and spores in the dermis, and Purpureocillium lilacinum was identified through tissue culture, polymerase chain reaction, and DNA sequencing. The skin lesion barely responded to 4 weeks of itraconazole treatment but improved upon the addition of terbinafine. The skin lesion was completely cured after 12 weeks, with no recurrence to date. Here, we report a rare deep cutaneous fungal infection caused by P. lilacinum in an immunocompetent patient and postulate that, in this case, the patient's agricultural lifestyle increased the possibility of P. lilacinum infection.
紫毛霉是腐生真菌的一个属,通常在土壤或腐烂物质中发现。虽然很少是人类的病原体,但它可以在免疫功能低下的患者中引起严重感染。85岁女性,右前臂和手背瘙痒性红斑斑块伴淡黄色结痂2周。组织病理学分析在真皮中鉴定出真菌菌丝和孢子,通过组织培养、聚合酶链反应和DNA测序鉴定出紫丁香紫孢。皮肤病变对伊曲康唑治疗4周几乎没有反应,但在添加特比萘芬后有所改善。12周后皮肤病变完全治愈,至今无复发。在这里,我们报告了一例罕见的由紫丁香假单胞菌引起的皮肤深部真菌感染,并假设,在这种情况下,患者的农业生活方式增加了紫丁香假单胞菌感染的可能性。
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引用次数: 1
A Case of Fingernail Onychomycosis Caused by Fusarium proliferatum 增殖镰刀菌致指甲甲真菌病1例
Q4 Medicine Pub Date : 2019-06-30 DOI: 10.17966/JMI.2019.24.2.58
E. H. Hong, Y. Jang, E. Cho, E. Park, Kwang-Joong Kim, K. Kim
Onychomycosis is a fungal nail infection caused mainly by dermatophytes. Non-dermatophytes such as yeasts, Acremonium, Aspergillus, and Fusarium species account for only 10% of onychomycosis, and Fusarium species are relatively common amongst these pathogens. However, the main Fusarium species pathogens are Fusarium solani and Fusarium oxysporum. Fusarium proliferatum is a rare pathogen in onychomycosis, and only a few cases have been reported worldwide. We report a case of a 68-year-old woman presenting with a white- to yellow-colored patch on her left third fingernail plate, which was diagnosed by fungus culture and sequencing as onychomycosis caused by Fusarium proliferatum.
甲真菌病是一种主要由皮肤真菌引起的指甲真菌感染。非皮肤真菌,如酵母、顶孢菌、曲霉菌和镰刀菌,只占10%的甲真菌病,镰刀菌在这些病原体中相对常见。然而,主要的镰刀菌种类病原体是茄枯菌和尖孢镰刀菌。增生镰刀菌是一种罕见的病原菌,在世界范围内报道的病例很少。我们报告一个68岁的妇女,表现为一个白色到黄色斑块在她的左第三指甲板,这是由真菌培养和测序诊断为甲真菌病引起的增生镰刀菌。
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引用次数: 1
Pityriasis Versicolor on Becker's Nevus Becker痣上的糠疹
Q4 Medicine Pub Date : 2019-06-30 DOI: 10.17966/JMI.2019.24.2.63
D. Oh, Ji Sun Kim, Hyun Yi Lee, Yuo-Jin Jeon, Joong-Sun Lee, D. Koo, K. Jung
{"title":"Pityriasis Versicolor on Becker's Nevus","authors":"D. Oh, Ji Sun Kim, Hyun Yi Lee, Yuo-Jin Jeon, Joong-Sun Lee, D. Koo, K. Jung","doi":"10.17966/JMI.2019.24.2.63","DOIUrl":"https://doi.org/10.17966/JMI.2019.24.2.63","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41672489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macroscopic and Microscopic Findings of Pseudallescheria boydii 博伊迪假丝酵母的宏观和微观发现
Q4 Medicine Pub Date : 2019-06-30 DOI: 10.17966/JMI.2019.24.2.66
Yongwoo Choi, Nuri Na, J. Choi, Joonsoo Park
{"title":"Macroscopic and Microscopic Findings of Pseudallescheria boydii","authors":"Yongwoo Choi, Nuri Na, J. Choi, Joonsoo Park","doi":"10.17966/JMI.2019.24.2.66","DOIUrl":"https://doi.org/10.17966/JMI.2019.24.2.66","url":null,"abstract":"","PeriodicalId":36021,"journal":{"name":"Journal of Mycology and Infection","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47053523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Mycology and Infection
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