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The predictive validity of MCAT scores and undergraduate GPA for COMLEX-USA licensure exam performance of students enrolled in osteopathic medical schools. 骨科医学院学生的 MCAT 分数和本科 GPA 对 COMLEX-USA 执业资格考试成绩的预测有效性。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-18 DOI: 10.1515/jom-2023-0265
Kenneth D Royal, Christian Meyer, Erik Guercio, Mark Speicher, Joseph Flamini, Jeanne M Sandella, Tsung-Hsun Tsai, Cynthia A Searcy

Context: Osteopathic (Doctor of Osteopathic Medicine [DO]) medical students account for more than 25 % of all medical students in the United States.

Objectives: This study examined the predictive validity of Medical College Admission Test (MCAT) total scores and cumulative undergraduate grade point averages (UGPAs) for performance on the Comprehensive Osteopathic Medical Licensing Examination of the United States (COMLEX-USA) Level 1 and Level 2-CE (Cognitive Evaluation) licensure examinations administered by the National Board of Osteopathic Medical Examiners (NBOME). Additionally, the study examined the degree to which MCAT total scores and UGPAs provide comparable prediction of student performance by key sociodemographic variables.

Methods: This study involved a collaborative effort between the Association of American Medical Colleges (AAMC), the American Association of Colleges of Osteopathic Medicine (AACOM) and the NBOME. Data were examined for 39 accredited DO-granting medical schools in the United States during the 2017 application cycle. Researchers utilized three regression models that included MCAT total scores, cumulative UGPA, and combined MCAT total scores and cumulative UGPA to determine predictive validity. Researchers also examined the comparability of prediction for sociodemographic variables by examining the differences between observed and predicted error for both scores and pass/fail success rates.

Results: Medium to large correlations were discernible between MCAT total scores, UGPA, and COMLEX-USA examination outcomes. For both COMLEX-USA Level 1 and Level 2-CE scores and pass/fail outcomes, MCAT scores alone provided superior predictive value to UGPA alone. However, MCAT scores and UGPA utilized in conjunction provided the best predictive value. When predicting both licensure examination scores and pass/fail outcomes by sociodemographic variables, all three models provided comparable predictive accuracy.

Conclusions: Findings from this comprehensive study of DO-granting medical schools provide evidence for the value-added benefit of taking MCAT scores and UGPA into consideration, particularly when these measures are utilized in conjunction. Further, findings provide evidence indicating that individuals from different sociodemographic backgrounds who enter medical school with similar MCAT scores and UGPA perform similarly on licensure examination outcome measures.

背景:在美国,骨科(骨科医学博士)医学生占医学生总数的 25% 以上:本研究探讨了医学院入学考试(MCAT)总分和本科生累积平均学分绩点(UGPA)对美国骨科医学考试委员会(NBOME)举办的美国骨科医学执照综合考试(COMLEX-USA)一级和二级-CE(认知评估)执照考试成绩的预测有效性。此外,该研究还考察了 MCAT 总分和 UGPA 在多大程度上可以通过关键的社会人口变量来预测学生的成绩:本研究由美国医学院协会(AAMC)、美国骨科医学院协会(AACOM)和美国国家医学考试委员会(NBOME)合作进行。在2017年申请周期内,研究人员对美国39所经认可的授予直博学位的医学院进行了数据调查。研究人员使用了三个回归模型,包括 MCAT 总分、累计 UGPA 以及 MCAT 总分和累计 UGPA 的组合,以确定预测有效性。研究人员还通过研究分数和及格/不及格成功率的观察误差与预测误差之间的差异,检验了社会人口变量预测的可比性:MCAT总分、UGPA和COMLEX-USA考试结果之间存在中到较大的相关性。对于 COMLEX-USA 1 级和 2 级-CE 分数以及及格/不及格结果,单凭 MCAT 分数的预测价值优于单凭 UGPA 的预测价值。然而,MCAT 分数和 UGPA 结合使用则具有最佳预测价值。在通过社会人口变量预测执业资格考试成绩和及格/不及格结果时,所有三个模型的预测准确性相当:这项对授予博士学位的医学院校进行的综合研究结果证明,将 MCAT 分数和 UGPA 考虑在内具有增值效益,尤其是当这些指标结合使用时。此外,研究结果还提供了证据,表明来自不同社会人口背景、以相似的 MCAT 分数和 UGPA 进入医学院的学生在执业资格考试结果测量中的表现相似。
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引用次数: 0
Assessing osteoporosis screening compliance in total joint surgery: a retrospective chart review. 评估全关节手术中骨质疏松症筛查的依从性:回顾性病历审查。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-05 DOI: 10.1515/jom-2024-0044
Samuel Shepard, Ania Bartholomew, David Houserman, H Brent Bamberger, Antonio G Manocchio

Context: Osteoporosis is a prevalent concern, particularly among aging populations, leading to increased risk of fractures, including those related to hip and knee arthroplasty procedures. Screening for osteoporosis, especially with dual X-ray absorptiometry (DXA) scans, is crucial for early detection and management.

Objectives: This study aimed to assess adherence to osteoporosis screening guidelines among patients aged 65 and older undergoing elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) within a single health network. Factors influencing screening adherence were also explored.

Methods: A retrospective chart review of 2,160 patients undergoing elective THA or TKA between January 2019 and January 2023 was conducted. Demographic data, osteoporosis screening status, and occurrence of periprosthetic fractures were analyzed. Statistical analysis included descriptive statistics and chi-square tests.

Results: Only 24.1 % of eligible patients underwent a DXA scan prior to surgery. Females were more likely to undergo screening than males, and race was also associated with screening status. A total of 45 periprosthetic fractures were identified, with no significant correlation between osteoporosis status, DXA screening, and fracture occurrence.

Conclusions: Adherence to osteoporosis screening guidelines among geriatric patients undergoing elective total joint arthroplasty remains low within the studied health network. Despite the lack of correlation between screening and fracture occurrence in this study, the importance of screening and potential optimization in high-risk patients is emphasized. Further research is needed to assess outcomes associated with different care pathways in bone health screening and management for elective geriatric total joint patients.

背景:骨质疏松症是一个普遍关注的问题,尤其是在老龄人口中,导致骨折风险增加,包括与髋关节和膝关节置换术相关的骨折。骨质疏松症筛查,尤其是双 X 射线吸收测定法(DXA)扫描,对于早期发现和管理骨质疏松症至关重要:本研究旨在评估在一个医疗网络内接受择期全髋关节置换术(THA)或全膝关节置换术(TKA)的 65 岁及以上患者对骨质疏松症筛查指南的依从性。此外,还探讨了影响筛查依从性的因素:对 2019 年 1 月至 2023 年 1 月期间接受择期 THA 或 TKA 的 2160 名患者进行了回顾性病历审查。分析了人口统计学数据、骨质疏松症筛查情况和假体周围骨折发生情况。统计分析包括描述性统计和卡方检验:结果:只有 24.1% 的合格患者在手术前接受了 DXA 扫描。女性比男性更有可能接受筛查,种族也与筛查情况有关。共发现45例假体周围骨折,骨质疏松症状况、DXA筛查和骨折发生率之间无明显相关性:结论:在所研究的医疗网络中,接受择期全关节置换术的老年患者对骨质疏松症筛查指南的依从性仍然很低。尽管本研究中筛查与骨折发生率之间缺乏相关性,但仍强调了筛查的重要性以及对高风险患者进行潜在优化的重要性。需要进一步开展研究,评估不同护理路径在骨健康筛查和管理老年全关节择期手术患者方面的相关结果。
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引用次数: 0
Feasibility of a cinematic-virtual reality training program about opioid use disorder for osteopathic medical students: a single-arm pre-post study. 针对骨科医学生的阿片类药物使用障碍的电影-虚拟现实培训计划的可行性:单臂前-后研究。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-05 DOI: 10.1515/jom-2023-0188
Dominique Rehl, Mason Mangapora, Matthew Love, Carrie Love, Kerri Shaw, John McCarthy, Elizabeth A Beverly

Context: Opioid use disorder (OUD) has a considerable morbidity and mortality in the United States. Healthcare providers are key points of contact for those with OUD; however, some providers may hold stigma toward OUD. Stigma toward OUD can lead to lower quality of care and more negative health outcomes. Thus, new trainings designed to reduce stigma toward OUD while increasing empathy are critical. We created a web-based cinematic virtual reality (cine-VR) training program on OUD for osteopathic medical students.

Objectives: The aim of this pilot study was to assess changes in stigma toward OUD and empathy before and after the online cine-VR training program on OUD.

Methods: We employed a single-arm, pre- and posttest pilot study to assess changes in stigma toward OUD and empathy. Osteopathic medical students from one large medical school in the Midwest with three campuses were invited to participate in the online cine-VR training. Participants completed two surveys before and after the cine-VR training. We performed paired t tests to examine changes in stigma toward OUD and empathy scores before and after the cine-VR OUD training program.

Results: A total of 48 participants completed the training. We observed a decrease in stigma toward OUD posttraining (t=4.402, p<0.001); this change had a Cohen's d of 0.64, indicating a medium effect. We also observed an increase in participants' empathy scores posttraining (t=-2.376, p=0.023), with a Cohen's d of 0.40 signifying a small effect.

Conclusions: Findings from this pilot study suggest that the online cine-VR training may reduce stigma toward OUD while increasing empathy. Future research employing a randomized controlled trial design with a larger, more diverse sample and a proper attention control condition is needed to confirm the effectiveness of the online cine-VR training. If confirmed, this cine-VR training may be an accessible approach to educating osteopathic medical students about OUD.

背景:在美国,阿片类药物使用障碍(OUD)的发病率和死亡率都很高。医疗服务提供者是阿片类药物滥用症患者的关键接触点;然而,一些医疗服务提供者可能对阿片类药物滥用症持有成见。对 OUD 的成见可能会导致护理质量下降和更多的负面健康结果。因此,旨在减少对 OUD 的污名化同时增加同理心的新培训至关重要。我们为骨科医科学生创建了一个基于网络的电影虚拟现实(cine-VR)培训项目:本试验性研究旨在评估OUD在线电影虚拟现实培训项目前后,对OUD的成见和同理心的变化:我们采用了单臂、前后测试的试验性研究来评估对 OUD 的成见和移情的变化。来自美国中西部一所拥有三个校区的大型医学院的骨科医学生应邀参加了在线电影-VR 培训。参与者在电影-VR 培训前后分别完成了两份调查问卷。我们进行了配对 t 检验,以检查在电影-VR OUD 培训项目前后,对 OUD 的污名化和移情评分的变化:共有 48 名参与者完成了培训。我们观察到,培训后参与者对 OUD 的成见有所减少(t=4.402,pd 为 0.64,表明效果中等)。我们还观察到,培训后参与者的移情得分有所提高(t=-2.376,p=0.023),科恩氏 d 为 0.40,表明效果较小:这项试点研究的结果表明,在线电影-VR 培训可以减少对 OUD 的污名化,同时增加同理心。未来的研究需要采用随机对照试验的设计,使用更大、更多样化的样本和适当的注意力控制条件,以证实在线电影-VR 培训的有效性。如果得到证实,这种电影-VR 培训可能是对骨科医学生进行 OUD 教育的一种便捷方法。
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引用次数: 0
Corrigendum to: A superficial dissection approach to the sphenopalatine (pterygopalatine) ganglion to emphasize osteopathic clinical relevance. 更正:椎节(翼腭神经节)浅层解剖方法,强调整骨疗法的临床意义。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-03 DOI: 10.1515/jom-2024-0120
Olivia C Matz, Laura J Rudberg-Post, Hannah C Gustafson, Lauren E Hartwell, Donald G Matz
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引用次数: 0
Preference signaling in orthopaedic surgery: applicant perspectives and opinions. 矫形外科的偏好信号:申请人的观点和意见。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-03 DOI: 10.1515/jom-2023-0127
Conner Howard, Victor H Martinez, Griffin Hughes, Aroob Zaheer, Christian Allen, Chad Hanson, Brent Norris, Jake X Checketts

Context: Orthopaedic surgery has become increasingly competitive over the years, with the COVID-19 pandemic creating additional challenges for applicants and programs. To promote an equitable match experience, the American Orthopaedic Association (AOA) introduced a formal preference signaling (PS) system into the 2022-2023 application cycle. PS allows applicants to indicate their heightened interest in specific programs, which improves the likelihood of receiving an interview and ultimately matching at their desired residency program.

Objectives: The objective of this anonymous survey is to assess applicants' opinions and perspectives toward PS in orthopaedic surgery prior to the 2022-2023 match results. Additionally, we sought to evaluate the signaling strategies being utilized by applicants.

Methods: An anonymous 22-question survey was distributed to applicants of an orthopaedic surgery residency program (34.2 % response rate). Responses were collected after the application submission deadline but before the match lists and results were available. This survey included questions germane to demographics, signal utilization, signaling reasons and strategies, and opinions toward PS. Descriptive statistics were calculated utilizing R (version 4.2.1) and RStudio.

Results: Most respondents (96.1 %) participated in PS, and 96.7 % utilized all 30 signals. Signaling encouraged 24.2 % of applicants to apply to fewer programs. In accordance with guidelines, 83.2 % of respondents signaled each away rotation program; however, only 53 % signaled their home program. Applicants commonly signaled 1-10 "reach" and "safety" programs each. Proximity to Family and Perceived Operative Experience were the most important reasons for signaling, whereas Program Prestige was the least. A program's social presence and virtual interview option did not influence many applicants' decisions for signaling. Most applicants believe that the COVID-19 pandemic and pass/fail licensure examinations influenced PS adoption. Sixty-seven of 149 respondents (45 %) claimed that applicants and programs benefit equally from PS, while 41 % believe programs benefit more. Nearly half (40.94 %) knew very little or nothing about PS.

Conclusions: During the inaugural introduction of PS in orthopaedic surgery, nearly every applicant utilized all 30 signals, prioritizing factors like family proximity and perceived operative experience over program prestige. This shift reflects the importance of geographic location and presumed training quality. Despite unfamiliarity toward PS, personalized signaling strategies were implemented, accompanied by a slight decrease in application volumes. The 30 allotted signals in orthopaedic surgery may serve as an informal application cap due to the necessity of signaling a program for an interview invite. However, improved

背景:多年来,骨科手术的竞争日趋激烈,COVID-19 大流行为申请人和项目带来了更多挑战。为了促进公平的匹配体验,美国矫形外科协会(AOA)在 2022-2023 年申请周期中引入了正式的偏好信号(PS)系统。PS允许申请者表明他们对特定项目的浓厚兴趣,从而提高获得面试的可能性,并最终匹配到理想的住院医师项目:这项匿名调查的目的是在 2022-2023 年匹配结果出来之前,评估申请人对骨科手术 PS 的意见和看法。此外,我们还试图评估申请人正在使用的信号策略:我们向骨科外科住院医师项目的申请人发放了一份包含 22 个问题的匿名调查问卷(回复率为 34.2%)。调查是在申请截止日期之后、匹配名单和结果公布之前收集的。该调查包括人口统计学、信号使用、信号原因和策略以及对 PS 的看法等相关问题。使用 R(4.2.1 版)和 RStudio 计算了描述性统计结果:大多数受访者(96.1%)参与了 PS,96.7% 的受访者使用了所有 30 种信号。24.2%的申请者通过信号鼓励自己申请更少的项目。根据指导原则,83.2% 的受访者在每个客场轮换项目中都打出了信号;但只有 53% 的受访者在自己的主场项目中打出了信号。申请者通常会选择 1-10 个 "可到达 "和 "安全 "的项目。与家人的近距离和感知到的操作经验是选择项目的最重要原因,而项目声望则是最不重要的原因。项目的社会影响力和虚拟面试选项并不影响许多申请人做出选择。大多数申请人认为 COVID-19 大流行和通过/未通过执照考试影响了 PS 的采用。149 位受访者中有 67 位(45%)认为申请人和项目从 PS 中获益相同,41% 的受访者认为项目获益更多。近一半的受访者(40.94%)对 PS 知之甚少或一无所知:在矫形外科首次引入 PS 期间,几乎所有申请者都使用了全部 30 个信号,优先考虑的因素是家庭邻近程度和感知的手术经验,而不是项目声誉。这一转变反映了地理位置和假定培训质量的重要性。尽管对 PS 并不熟悉,但个性化信号策略还是得到了实施,同时申请量也略有下降。骨科手术中分配的 30 个信号可能是一个非正式的申请上限,因为必须向一个项目发出信号才能获得面试邀请。不过,还需要加强教育工作,以提高申请者和项目对 PS 的理解,并最大限度地发挥 PS 的优势。
{"title":"Preference signaling in orthopaedic surgery: applicant perspectives and opinions.","authors":"Conner Howard, Victor H Martinez, Griffin Hughes, Aroob Zaheer, Christian Allen, Chad Hanson, Brent Norris, Jake X Checketts","doi":"10.1515/jom-2023-0127","DOIUrl":"https://doi.org/10.1515/jom-2023-0127","url":null,"abstract":"<p><strong>Context: </strong>Orthopaedic surgery has become increasingly competitive over the years, with the COVID-19 pandemic creating additional challenges for applicants and programs. To promote an equitable match experience, the American Orthopaedic Association (AOA) introduced a formal preference signaling (PS) system into the 2022-2023 application cycle. PS allows applicants to indicate their heightened interest in specific programs, which improves the likelihood of receiving an interview and ultimately matching at their desired residency program.</p><p><strong>Objectives: </strong>The objective of this anonymous survey is to assess applicants' opinions and perspectives toward PS in orthopaedic surgery prior to the 2022-2023 match results. Additionally, we sought to evaluate the signaling strategies being utilized by applicants.</p><p><strong>Methods: </strong>An anonymous 22-question survey was distributed to applicants of an orthopaedic surgery residency program (34.2 % response rate). Responses were collected after the application submission deadline but before the match lists and results were available. This survey included questions germane to demographics, signal utilization, signaling reasons and strategies, and opinions toward PS. Descriptive statistics were calculated utilizing R (version 4.2.1) and RStudio.</p><p><strong>Results: </strong>Most respondents (96.1 %) participated in PS, and 96.7 % utilized all 30 signals. Signaling encouraged 24.2 % of applicants to apply to fewer programs. In accordance with guidelines, 83.2 % of respondents signaled each away rotation program; however, only 53 % signaled their home program. Applicants commonly signaled 1-10 \"reach\" and \"safety\" programs each. <i>Proximity to Family</i> and <i>Perceived Operative Experience</i> were the most important reasons for signaling, whereas <i>Program Prestige</i> was the least. A program's social presence and virtual interview option did not influence many applicants' decisions for signaling. Most applicants believe that the COVID-19 pandemic and pass/fail licensure examinations influenced PS adoption. Sixty-seven of 149 respondents (45 %) claimed that applicants and programs benefit equally from PS, while 41 % believe programs benefit more. Nearly half (40.94 %) knew <i>very little</i> or <i>nothing</i> about PS.</p><p><strong>Conclusions: </strong>During the inaugural introduction of PS in orthopaedic surgery, nearly every applicant utilized all 30 signals, prioritizing factors like family proximity and perceived operative experience over program prestige. This shift reflects the importance of geographic location and presumed training quality. Despite unfamiliarity toward PS, personalized signaling strategies were implemented, accompanied by a slight decrease in application volumes. The 30 allotted signals in orthopaedic surgery may serve as an informal application cap due to the necessity of signaling a program for an interview invite. However, improved","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating trends in orthopedic surgery match for osteopathic and allopathic graduates post-single accreditation transition. 调查单一认证过渡后骨科和全科毕业生骨科手术匹配的趋势。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-28 DOI: 10.1515/jom-2024-0064
Michael Megafu, Omar D Guerrero
{"title":"Investigating trends in orthopedic surgery match for osteopathic and allopathic graduates post-single accreditation transition.","authors":"Michael Megafu, Omar D Guerrero","doi":"10.1515/jom-2024-0064","DOIUrl":"https://doi.org/10.1515/jom-2024-0064","url":null,"abstract":"","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of prenatal substance exposure and the development of the amygdala, hippocampus, and parahippocampus. 产前接触药物与杏仁核、海马和副海马发育的关系。
IF 1.4 Q2 Health Professions Pub Date : 2024-06-26 DOI: 10.1515/jom-2023-0277
Micah Hartwell, Molly Bloom, Covenant Elenwo, Trey Gooch, Kelly Dunn, Florence Breslin, Julie M Croff

Context: Prenatal substance exposure (PSE) can lead to various harmful outcomes for the developing fetus and is linked to many emotional, behavioral, and cognitive difficulties later in life. Therefore, examination of the relationship between the development of associated brain structures and PSE is important for the development of more specific or new preventative methods.

Objectives: Our study's primary objective was to examine the relationship between the physical development of the amygdala, hippocampus, and parahippocampus following prenatal alcohol, tobacco, and prescription opioid exposure.

Methods: We conducted a cross-sectional analysis of the Adolescent Brain and Cognitive Development (ABCD) Study, a longitudinal neuroimaging study that measures brain morphometry from childhood throughout adolescence. Data were collected from approximately 12,000 children (ages 9 and 10) and parents across 22 sites within the United States. Prenatal opioid, tobacco, and alcohol use was determined through parent self-report of use during pregnancy. We extracted variables assessing the volumetric size (mm3) of the amygdala, hippocampus, and parahippocampal gyrus as well as brain volume, poverty level, age, sex, and race/ethnicity for controls within our adjusted models. We reported sociodemographic characteristics of the sample overall and by children who had PSE. We calculated and reported the means of each of the specific brain regions by substance exposure. Finally, we constructed multivariable regression models to measure the associations between different PSE and the demographic characteristics, total brain volume, and volume of each brain structure.

Results: Among the total sample, 24.6% had prenatal alcohol exposure, 13.6% had prenatal tobacco exposure, and 1.2% had prenatal opioid exposure. On average, those with prenatal tobacco exposure were found to have a statistically significant smaller parahippocampus.

Conclusions: We found a significant association between prenatal tobacco exposure and smaller parahippocampal volume, which may have profound impacts on the livelihood of individuals including motor delays, poor cognitive and behavioral outcomes, and long-term health consequences. Given the cumulative neurodevelopmental effects associated with PSE, we recommend that healthcare providers increase screening rates, detection, and referrals for cessation. Additionally, we recommend that medical associations lobby policymakers to address upstream barriers to the effective identification of at-risk pregnant individuals, specifically, eliminating or significantly reducing punitive legal consequences stemming from state laws concerning prenatal substance use.

背景:产前药物暴露(PSE)可导致胎儿发育过程中的各种有害结果,并与日后生活中的许多情绪、行为和认知障碍有关。因此,研究相关大脑结构的发育与 PSE 之间的关系对于开发更具体或新的预防方法非常重要:我们研究的主要目的是探讨产前接触酒精、烟草和处方阿片类药物后杏仁核、海马和副海马的生理发育之间的关系:我们对青少年大脑和认知发展(ABCD)研究进行了横断面分析,该研究是一项纵向神经影像学研究,用于测量从童年到青春期的大脑形态测量。该研究收集了美国 22 个研究机构约 12,000 名儿童(9 岁和 10 岁)和家长的数据。产前使用阿片类药物、烟草和酒精的情况是通过家长对孕期使用情况的自我报告确定的。我们在调整模型中提取了评估杏仁核、海马和海马旁回体积大小(mm3)的变量,以及对照组的脑容量、贫困程度、年龄、性别和种族/民族。我们报告了样本总体的社会人口学特征以及患有 PSE 儿童的社会人口学特征。我们计算并报告了每个特定脑区的物质暴露平均值。最后,我们建立了多变量回归模型,以衡量不同 PSE 与人口统计学特征、大脑总体积和各大脑结构体积之间的关联:在所有样本中,24.6%的人在产前接触过酒精,13.6%的人在产前接触过烟草,1.2%的人在产前接触过阿片类药物。平均而言,产前接触过烟草的婴儿的海马旁较小,这在统计学上有显著意义:我们发现,产前烟草暴露与海马体旁体积变小之间存在明显关联,这可能会对个体的生活产生深远影响,包括运动迟缓、认知和行为结果不良以及长期的健康后果。鉴于 PSE 对神经发育的累积影响,我们建议医疗保健提供者提高筛查率、检测率和戒烟转诊率。此外,我们还建议医疗协会游说政策制定者,以解决有效识别高危孕妇的上游障碍,特别是消除或大幅减少各州关于产前药物使用的法律所产生的惩罚性法律后果。
{"title":"Association of prenatal substance exposure and the development of the amygdala, hippocampus, and parahippocampus.","authors":"Micah Hartwell, Molly Bloom, Covenant Elenwo, Trey Gooch, Kelly Dunn, Florence Breslin, Julie M Croff","doi":"10.1515/jom-2023-0277","DOIUrl":"https://doi.org/10.1515/jom-2023-0277","url":null,"abstract":"<p><strong>Context: </strong>Prenatal substance exposure (PSE) can lead to various harmful outcomes for the developing fetus and is linked to many emotional, behavioral, and cognitive difficulties later in life. Therefore, examination of the relationship between the development of associated brain structures and PSE is important for the development of more specific or new preventative methods.</p><p><strong>Objectives: </strong>Our study's primary objective was to examine the relationship between the physical development of the amygdala, hippocampus, and parahippocampus following prenatal alcohol, tobacco, and prescription opioid exposure.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of the Adolescent Brain and Cognitive Development (ABCD) Study, a longitudinal neuroimaging study that measures brain morphometry from childhood throughout adolescence. Data were collected from approximately 12,000 children (ages 9 and 10) and parents across 22 sites within the United States. Prenatal opioid, tobacco, and alcohol use was determined through parent self-report of use during pregnancy. We extracted variables assessing the volumetric size (mm<sup>3</sup>) of the amygdala, hippocampus, and parahippocampal gyrus as well as brain volume, poverty level, age, sex, and race/ethnicity for controls within our adjusted models. We reported sociodemographic characteristics of the sample overall and by children who had PSE. We calculated and reported the means of each of the specific brain regions by substance exposure. Finally, we constructed multivariable regression models to measure the associations between different PSE and the demographic characteristics, total brain volume, and volume of each brain structure.</p><p><strong>Results: </strong>Among the total sample, 24.6% had prenatal alcohol exposure, 13.6% had prenatal tobacco exposure, and 1.2% had prenatal opioid exposure. On average, those with prenatal tobacco exposure were found to have a statistically significant smaller parahippocampus.</p><p><strong>Conclusions: </strong>We found a significant association between prenatal tobacco exposure and smaller parahippocampal volume, which may have profound impacts on the livelihood of individuals including motor delays, poor cognitive and behavioral outcomes, and long-term health consequences. Given the cumulative neurodevelopmental effects associated with PSE, we recommend that healthcare providers increase screening rates, detection, and referrals for cessation. Additionally, we recommend that medical associations lobby policymakers to address upstream barriers to the effective identification of at-risk pregnant individuals, specifically, eliminating or significantly reducing punitive legal consequences stemming from state laws concerning prenatal substance use.</p>","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to "Fostering a research culture in osteopathic medical education". 对 "在骨科医学教育中培养研究文化 "的回应。
IF 1.5 Q2 Health Professions Pub Date : 2024-06-21 DOI: 10.1515/jom-2024-0093
Angela Ho, Alyssa Auerbach, Jantzen J Faulkner, Satvinder K Guru, Amber Lee, David Manna
{"title":"Response to \"Fostering a research culture in osteopathic medical education\".","authors":"Angela Ho, Alyssa Auerbach, Jantzen J Faulkner, Satvinder K Guru, Amber Lee, David Manna","doi":"10.1515/jom-2024-0093","DOIUrl":"https://doi.org/10.1515/jom-2024-0093","url":null,"abstract":"","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to: Regarding "Issues of informed consent for non-specialists conducting colorectal cancer screenings". 回应:关于 "非专科医生进行结直肠癌筛查的知情同意问题"。
IF 1.5 Q2 Health Professions Pub Date : 2024-06-21 DOI: 10.1515/jom-2024-0113
Forrest Bohler, Allison Garden
{"title":"Response to: Regarding \"Issues of informed consent for non-specialists conducting colorectal cancer screenings\".","authors":"Forrest Bohler, Allison Garden","doi":"10.1515/jom-2024-0113","DOIUrl":"https://doi.org/10.1515/jom-2024-0113","url":null,"abstract":"","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regarding "Issues of informed consent for non-specialists conducting colorectal cancer screenings". 关于 "非专科医生进行结直肠癌筛查的知情同意问题"。
IF 1.5 Q2 Health Professions Pub Date : 2024-06-11 DOI: 10.1515/jom-2024-0026
Sareena Ali, Robert Mowery, Ryan T Hoff
{"title":"Regarding \"Issues of informed consent for non-specialists conducting colorectal cancer screenings\".","authors":"Sareena Ali, Robert Mowery, Ryan T Hoff","doi":"10.1515/jom-2024-0026","DOIUrl":"https://doi.org/10.1515/jom-2024-0026","url":null,"abstract":"","PeriodicalId":36050,"journal":{"name":"Journal of Osteopathic Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Osteopathic Medicine
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