Pub Date : 2021-09-26DOI: 10.31117/neuroscirn.v4i3.75
Y. Yusha’u, U. Adam, A. A. Wahab, M. Saleh, J. Ya’u
Depression affects over 264 million people of all ages globally. Major depressive disorder significantly and chronically reduced quality of life by its association with functional impairment both at home and in the workplace. Depressive patients consistently complain about cognitive disturbances, significantly exacerbating the burden of this illness. Several studies have shown that alpha-lipoic acid (ALA) possesses mitochondrial, antioxidant, anti-inflammatory and anti-diabetic properties, indicating a basis for evaluating the efficacy of ALA in depression. Hence, this research aimed to assess the possible anti-depressant effect of ALA in mice exposed to the open space forced swim test (OSFST) model of depression. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group 1: [Normal saline (NS)], Groups 2, 3 and 4 received graded doses of ALA 100, 200 and 400 mg/kg, respectively, Group 5 received fluoxetine 20 mg/kg orally. The animals were subjected to OSFST, novel object recognition test (NORT) and Y-maze test. Serotonin, brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase levels of the mice were assessed. Treatment with ALA and fluoxetine significantly decreased immobility time compared to NS group in OSFST (p<0.05). Also, ALA at doses of 200 & 400 mg/kg and fluoxetine 20 mg/kg significantly increased spontaneous alternation ratio in the Y-maze test compared to the normal saline group (p<0.05), however, no significant difference was observed in novel object recognition using NORT between NS, ALA and fluoxetine treated groups. Similarly, the level of serotonin, SOD and catalase were not altered between the ALA and fluoxetine treated groups and NS group. In contrast, fluoxetine 20 mg/kg increased the brain BDNF level of the mice (p<0.05). Alpha-lipoic acid ameliorated depression in the OSFST murine model of depression and improved their cognition. Thus ALA can be a promising candidate in the development of novel anti-depressant medication.
{"title":"Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model","authors":"Y. Yusha’u, U. Adam, A. A. Wahab, M. Saleh, J. Ya’u","doi":"10.31117/neuroscirn.v4i3.75","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3.75","url":null,"abstract":"Depression affects over 264 million people of all ages globally. Major depressive disorder significantly and chronically reduced quality of life by its association with functional impairment both at home and in the workplace. Depressive patients consistently complain about cognitive disturbances, significantly exacerbating the burden of this illness. Several studies have shown that alpha-lipoic acid (ALA) possesses mitochondrial, antioxidant, anti-inflammatory and anti-diabetic properties, indicating a basis for evaluating the efficacy of ALA in depression. Hence, this research aimed to assess the possible anti-depressant effect of ALA in mice exposed to the open space forced swim test (OSFST) model of depression. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group 1: [Normal saline (NS)], Groups 2, 3 and 4 received graded doses of ALA 100, 200 and 400 mg/kg, respectively, Group 5 received fluoxetine 20 mg/kg orally. The animals were subjected to OSFST, novel object recognition test (NORT) and Y-maze test. Serotonin, brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase levels of the mice were assessed. Treatment with ALA and fluoxetine significantly decreased immobility time compared to NS group in OSFST (p<0.05). Also, ALA at doses of 200 & 400 mg/kg and fluoxetine 20 mg/kg significantly increased spontaneous alternation ratio in the Y-maze test compared to the normal saline group (p<0.05), however, no significant difference was observed in novel object recognition using NORT between NS, ALA and fluoxetine treated groups. Similarly, the level of serotonin, SOD and catalase were not altered between the ALA and fluoxetine treated groups and NS group. In contrast, fluoxetine 20 mg/kg increased the brain BDNF level of the mice (p<0.05). Alpha-lipoic acid ameliorated depression in the OSFST murine model of depression and improved their cognition. Thus ALA can be a promising candidate in the development of novel anti-depressant medication.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42307804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep is a vital component for maintaining good physical and mental health. When sleep is disordered, it can adversely affect an individual's mental and physical wellbeing. Although a variety of single specific disorder measurements are available for specialized clinicians use across the globe, to date, there are no proper screening instruments available for screening multiple sleep disorders at the primary care level. The purpose of this study is to determine the test-retest reliability of the sleep disorder screening questionnaire (SDSQ) for detecting multiple sleep disorders among the Mongolian population. A total of 366 university students were recruited for participation. SDSQ was administrated to all participants on two occasions two weeks apart. The test-retest reliability intra-class correlation (ICC) and Cronbach's alpha of the SDSQ were calculated. The sample consisted of 194 (53%) females, and 172 (47%) males, with a mean age of 21.6. Observed test-retest reliability was ranged from 0.53 to 0.81. The SDSQ was found to have excellent internal consistency with an alpha=0.950. The external validity of SDSQ revealed strong test-retest reliability in the current study population. The discriminant and convergent validity studies are required for the further improvement of the construct of the SDSQ.
{"title":"Test-retest reliability of the questionnaire on the screening of sleep disorders","authors":"E. Batkhuyag, Enkhnaran Tumurbaatar, Battuvshin Lkhagvasuren, Enkh-Uchral Perenleisambuu, Enkhjin Bat-Erdene, Myagmartseren Dashtseren, Otgontuya Duurenjargal, Xihua Zeng, Gantsetseg Tumur-Ochir","doi":"10.31117/neuroscirn.v4i3suppl.90","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3suppl.90","url":null,"abstract":"Sleep is a vital component for maintaining good physical and mental health. When sleep is disordered, it can adversely affect an individual's mental and physical wellbeing. Although a variety of single specific disorder measurements are available for specialized clinicians use across the globe, to date, there are no proper screening instruments available for screening multiple sleep disorders at the primary care level. The purpose of this study is to determine the test-retest reliability of the sleep disorder screening questionnaire (SDSQ) for detecting multiple sleep disorders among the Mongolian population. A total of 366 university students were recruited for participation. SDSQ was administrated to all participants on two occasions two weeks apart. The test-retest reliability intra-class correlation (ICC) and Cronbach's alpha of the SDSQ were calculated. The sample consisted of 194 (53%) females, and 172 (47%) males, with a mean age of 21.6. Observed test-retest reliability was ranged from 0.53 to 0.81. The SDSQ was found to have excellent internal consistency with an alpha=0.950. The external validity of SDSQ revealed strong test-retest reliability in the current study population. The discriminant and convergent validity studies are required for the further improvement of the construct of the SDSQ.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41648307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayurvedic medications originated centuries ago and are still prevalent today. Saraswatarishta (SWRT) is a well-known ayurvedic formulation that is often prescribed to control the manifestations of neurological illnesses and disorders such as slurred speech, anxiety, Parkinson's disease (PD) and Alzheimer's disease(AD). However, scientific research on its mode of action has not been studied extensively. Therefore, this study employs network pharmacology to understand better the neuroprotective role of Saraswatarishta (SWRT) in neurological disorders. Out of the 18 ingredients in SWRT, five were considered in this study due to their elevated therapeutic action in neurological disorders. Further, nine active phytoconstituents were chosen from the five selected ingredients. The gene targets of the active phytoconstituents were screened and selected using STITCH, SwissTargetPrediction and ChEMBL. Protein-Protein interaction and Gene Ontology (GO) enrichment analysis were carried out using STRING and g:Profiler, respectively. Cytoscape 3.7.2 was used to create three networks-the compound-target, the target-disease and the compound-target-disease network. Molinspiration and admetSAR2.0 were used to obtain the bioactivity scores and the blood-brain barrier (BBB) probability scores. The three networks indicated that all nine phytoconstituents were linked to the gene targets that encode proteins involved in the pathways of 10 major neurological disorders. This includes Parkinson's disease (PD), Alzheimer's disease (AD), dementia, Huntington disease, epilepsy, schizophrenia, spinocerebellar ataxia, amyotrophic lateral sclerosis (ALS), multiple sclerosis and attention deficit hyperactivity disorder (ADHD). The gene targets were expressed significantly in various central nervous system regions such as the cerebral cortex, cerebellum and amygdala. The bioactivity scores of the phytoconstituents were in the active range along with high BBB probability scores, indicating that the phytoconstituents can potentially cross the BBB and impart therapeutic effects.
{"title":"Analysing the role of Saraswatarishta in the treatment of neurological disorders based on network pharmacology","authors":"Vrinda Jethalia, Sanjana Varada Hasyagar, Kasturi Bhamidipati, Jhinuk Chatterjee","doi":"10.31117/neuroscirn.v3i5.106","DOIUrl":"https://doi.org/10.31117/neuroscirn.v3i5.106","url":null,"abstract":"Ayurvedic medications originated centuries ago and are still prevalent today. Saraswatarishta (SWRT) is a well-known ayurvedic formulation that is often prescribed to control the manifestations of neurological illnesses and disorders such as slurred speech, anxiety, Parkinson's disease (PD) and Alzheimer's disease(AD). However, scientific research on its mode of action has not been studied extensively. Therefore, this study employs network pharmacology to understand better the neuroprotective role of Saraswatarishta (SWRT) in neurological disorders. Out of the 18 ingredients in SWRT, five were considered in this study due to their elevated therapeutic action in neurological disorders. Further, nine active phytoconstituents were chosen from the five selected ingredients. The gene targets of the active phytoconstituents were screened and selected using STITCH, SwissTargetPrediction and ChEMBL. Protein-Protein interaction and Gene Ontology (GO) enrichment analysis were carried out using STRING and g:Profiler, respectively. Cytoscape 3.7.2 was used to create three networks-the compound-target, the target-disease and the compound-target-disease network. Molinspiration and admetSAR2.0 were used to obtain the bioactivity scores and the blood-brain barrier (BBB) probability scores. The three networks indicated that all nine phytoconstituents were linked to the gene targets that encode proteins involved in the pathways of 10 major neurological disorders. This includes Parkinson's disease (PD), Alzheimer's disease (AD), dementia, Huntington disease, epilepsy, schizophrenia, spinocerebellar ataxia, amyotrophic lateral sclerosis (ALS), multiple sclerosis and attention deficit hyperactivity disorder (ADHD). The gene targets were expressed significantly in various central nervous system regions such as the cerebral cortex, cerebellum and amygdala. The bioactivity scores of the phytoconstituents were in the active range along with high BBB probability scores, indicating that the phytoconstituents can potentially cross the BBB and impart therapeutic effects.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47296748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-16DOI: 10.31117/neuroscirn.v4i3suppl.99
D. Namjil, B. Dagvajantsan, Oyuntugs Byambasukh
Cognitive impairment is commonly associated with older people. It can also occur in middle-aged people due to non-communicable diseases. The prevalence of lifestyle-related diseases (non-communicable diseases) has been rapidly increasing in Mongolia. Therefore, we aimed to overview these studies to identify whether the increasing prevalence of non-communicable disease is associated with the risks of cognitive impairment in Mongolians. Published literature between 01 January 1980 and 20 June 2021 were included in the study. We searched articles published in journals registered to PubMed and doctoral and master's dissertations registered in the Central Medical Library of Mongolia using the following keywords: "cognitive impairment", "dementia", "mild cognitive impairment", "Alzheimer", "vascular dementia", “diabetes", "Mongolia", "obesity", "stroke", "hypertension". While there were no internationally published articles in this field, seven studies were either published in local research journals or as doctoral or master’s dissertations. Although few studies have been conducted in Mongolia, people with lifestyle-related conditions such as hypertension and diabetes are strongly associated with a higher risk of cognitive impairment. The increasing prevalence of non-communicable diseases may be one of the factors contributing to the prevalence of vascular cognitive impairment.
{"title":"Vascular cognitive impairment risk among Mongolian adults: An overview","authors":"D. Namjil, B. Dagvajantsan, Oyuntugs Byambasukh","doi":"10.31117/neuroscirn.v4i3suppl.99","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3suppl.99","url":null,"abstract":"Cognitive impairment is commonly associated with older people. It can also occur in middle-aged people due to non-communicable diseases. The prevalence of lifestyle-related diseases (non-communicable diseases) has been rapidly increasing in Mongolia. Therefore, we aimed to overview these studies to identify whether the increasing prevalence of non-communicable disease is associated with the risks of cognitive impairment in Mongolians. Published literature between 01 January 1980 and 20 June 2021 were included in the study. We searched articles published in journals registered to PubMed and doctoral and master's dissertations registered in the Central Medical Library of Mongolia using the following keywords: \"cognitive impairment\", \"dementia\", \"mild cognitive impairment\", \"Alzheimer\", \"vascular dementia\", “diabetes\", \"Mongolia\", \"obesity\", \"stroke\", \"hypertension\". While there were no internationally published articles in this field, seven studies were either published in local research journals or as doctoral or master’s dissertations. Although few studies have been conducted in Mongolia, people with lifestyle-related conditions such as hypertension and diabetes are strongly associated with a higher risk of cognitive impairment. The increasing prevalence of non-communicable diseases may be one of the factors contributing to the prevalence of vascular cognitive impairment.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41512654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-14DOI: 10.31117/neuroscirn.v4i3.79
Ahmed H. Alsharif, Nor Zafir Md. Salleh, Rohaizat Baharun
Neuromarketing (NM) uses neuroscience tools, for example, but not limited to functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to study, explore, analyze, and explain the neural correlates of consumer’s behavior (i.e., decision-making processes), the cognitive processes (i.e., attention and memory) and emotional processes (i.e., emotion) of interest for marketing research (e.g., advertising, brand, product, price). This study analyzes the relevant literature and sheds light on the triune brain of humans, the dimensions of NM such as emotion, attention, and memory. Currently, emotional and cognitive processes have remarkably received attention from academic and industrial environments. Thus, NM presents unrivalled possibilities to record the activity regions in consumers' brains and provide precise information about which neurons are active when consumers are exposed to marketing stimuli. To best our knowledge, this will aid in shaping and understanding the central theme and set the future research directions for the researchers.
{"title":"Neuromarketing: Marketing research in the new millennium","authors":"Ahmed H. Alsharif, Nor Zafir Md. Salleh, Rohaizat Baharun","doi":"10.31117/neuroscirn.v4i3.79","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3.79","url":null,"abstract":"Neuromarketing (NM) uses neuroscience tools, for example, but not limited to functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to study, explore, analyze, and explain the neural correlates of consumer’s behavior (i.e., decision-making processes), the cognitive processes (i.e., attention and memory) and emotional processes (i.e., emotion) of interest for marketing research (e.g., advertising, brand, product, price). This study analyzes the relevant literature and sheds light on the triune brain of humans, the dimensions of NM such as emotion, attention, and memory. Currently, emotional and cognitive processes have remarkably received attention from academic and industrial environments. Thus, NM presents unrivalled possibilities to record the activity regions in consumers' brains and provide precise information about which neurons are active when consumers are exposed to marketing stimuli. To best our knowledge, this will aid in shaping and understanding the central theme and set the future research directions for the researchers.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43586318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-04DOI: 10.31117/neuroscirn.v3i5.80
Ahmed H. Alsharif, Nor Zafir Md Salleh, Rohaizat Baharun
In the last two decades, neuromarketing (NM) studies are snowballed because scientists and researchers are looking for understanding the mechanisms of decision-making in the consumer's brain toward marketing stimuli, for example, but not limited to advertising and brands that have not changed overnight. For this purpose, NM research is using state-of-the-art technology to gauge the responses of consumers’ minds to marketing stimuli, which is impossible by traditional marketing methods. In this paper, we have concentrated on neuromarketing tools such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and eye-tracking (ET). Literature indicates that EEG, fMRI, and ET enable to gauge consumers' neurometrics and biometrics responses; thereby, they provide valuable information about the physiological and mental reactions toward marketing stimuli, which can be used to improve marketing research. Neuromarketing can provide valuable information about consumer behaviour, which is impossible by traditional methods. We hope that this study provides valuable insights into neuromarketing and future directions.
{"title":"Neuromarketing: The popularity of the brain-imaging and physiological tools","authors":"Ahmed H. Alsharif, Nor Zafir Md Salleh, Rohaizat Baharun","doi":"10.31117/neuroscirn.v3i5.80","DOIUrl":"https://doi.org/10.31117/neuroscirn.v3i5.80","url":null,"abstract":"In the last two decades, neuromarketing (NM) studies are snowballed because scientists and researchers are looking for understanding the mechanisms of decision-making in the consumer's brain toward marketing stimuli, for example, but not limited to advertising and brands that have not changed overnight. For this purpose, NM research is using state-of-the-art technology to gauge the responses of consumers’ minds to marketing stimuli, which is impossible by traditional marketing methods. In this paper, we have concentrated on neuromarketing tools such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and eye-tracking (ET). Literature indicates that EEG, fMRI, and ET enable to gauge consumers' neurometrics and biometrics responses; thereby, they provide valuable information about the physiological and mental reactions toward marketing stimuli, which can be used to improve marketing research. Neuromarketing can provide valuable information about consumer behaviour, which is impossible by traditional methods. We hope that this study provides valuable insights into neuromarketing and future directions.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41938851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-04DOI: 10.31117/neuroscirn.v4i3.83
Aida Azlina Bt. Mansor, S. Isa, S. S. M. Noor
Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of decision-making is P300. Thus, the P300 wave is a potential Event-Related Component (ERP) used to measure consumers' decision-making process. The P300 wave represents a positive transition in human event-related potential. Therefore, the P300 is determined by measuring the amplitude and latency of the consumers. A higher P300 amplitude indicates greater confidence in the decision-making process, while a longer P300 latency indicates lower attentiveness. Thus, P300 in neuroscience, which investigates customers' responses in-depth, cannot be accomplished by typical marketing methods. For many years, P300 components such as attitudes, preferences, and information-based decision-making have been examined extensively in marketing-related research. However, a review of an ERP in neuromarketing method is fewer reported. This mini review describes some analysis on P300 and decision-making by several researchers.
{"title":"P300 and decision-making in neuromarketing","authors":"Aida Azlina Bt. Mansor, S. Isa, S. S. M. Noor","doi":"10.31117/neuroscirn.v4i3.83","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3.83","url":null,"abstract":"Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of decision-making is P300. Thus, the P300 wave is a potential Event-Related Component (ERP) used to measure consumers' decision-making process. The P300 wave represents a positive transition in human event-related potential. Therefore, the P300 is determined by measuring the amplitude and latency of the consumers. A higher P300 amplitude indicates greater confidence in the decision-making process, while a longer P300 latency indicates lower attentiveness. Thus, P300 in neuroscience, which investigates customers' responses in-depth, cannot be accomplished by typical marketing methods. For many years, P300 components such as attitudes, preferences, and information-based decision-making have been examined extensively in marketing-related research. However, a review of an ERP in neuromarketing method is fewer reported. This mini review describes some analysis on P300 and decision-making by several researchers.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45131673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mongolia ranks third in the world in stroke-related deaths. Loss of skeletal muscle mass and function, known as sarcopenia, is associated with a higher risk of various metabolic disorders such as stroke. Thus, screening of sarcopenia is important. Hand-grip strength (HGS) can be used to predict sarcopenia in the short term. In this cross-sectional study, we used data (n=1180, mean age of 39.2 ± 15.2 and 33.2% males) from the Mon-Timeline cohort study, a multidisciplinary, prospective, population-based cohort study in Mongolia. A digital grip strength dynamometer (TKK 5401 GRIP D; Takei, Japan) was used to measure HGS. We performed binary logistic regression analysis between HGS and stroke risk. Suspected sarcopenia was defined when HGS is less than the 25th percentile of HGS. In this study, 3.3% of all participants had a stroke. The incidence of stroke was significantly higher (5.2% and 1.9%) in people with suspected sarcopenia. According to body composition, the incidence of stroke was more frequent in sarcopenic obese people: 1.3%, 2.4%, 2.8% and 6.2% in normal (non-obese and non-sarcopenic), sarcopenic (non-obese), obese (non-sarcopenic) and sarcopenic obese groups, respectively. In regression analysis, the OR (95% CI) was 2.84 (1.44; 5.59) for sarcopenic compared with non-sarcopenic. The adjustments for age, gender, education, body mass index, waist circumference and hypertensive status attenuated the associations, but lower HGS remained significantly associated with a higher risk of stroke. In conclusion, lower HGS was significantly associated with a higher risk of stroke independent of adiposity and hypertensive status in Mongolian adults.
{"title":"Association between hand-grip strength and risk of stroke among Mongolian adults: Results from a population-based study","authors":"Indra Altankhuyag, Agiimaa Byambaa, Anujin Tuvshinjargal, Anar Bayarmunkh, Tsolmon Jadamba, B. Dagvajantsan, Oyuntugs Byambasukh","doi":"10.31117/neuroscirn.v4i3suppl.97","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3suppl.97","url":null,"abstract":"Mongolia ranks third in the world in stroke-related deaths. Loss of skeletal muscle mass and function, known as sarcopenia, is associated with a higher risk of various metabolic disorders such as stroke. Thus, screening of sarcopenia is important. Hand-grip strength (HGS) can be used to predict sarcopenia in the short term. In this cross-sectional study, we used data (n=1180, mean age of 39.2 ± 15.2 and 33.2% males) from the Mon-Timeline cohort study, a multidisciplinary, prospective, population-based cohort study in Mongolia. A digital grip strength dynamometer (TKK 5401 GRIP D; Takei, Japan) was used to measure HGS. We performed binary logistic regression analysis between HGS and stroke risk. Suspected sarcopenia was defined when HGS is less than the 25th percentile of HGS. In this study, 3.3% of all participants had a stroke. The incidence of stroke was significantly higher (5.2% and 1.9%) in people with suspected sarcopenia. According to body composition, the incidence of stroke was more frequent in sarcopenic obese people: 1.3%, 2.4%, 2.8% and 6.2% in normal (non-obese and non-sarcopenic), sarcopenic (non-obese), obese (non-sarcopenic) and sarcopenic obese groups, respectively. In regression analysis, the OR (95% CI) was 2.84 (1.44; 5.59) for sarcopenic compared with non-sarcopenic. The adjustments for age, gender, education, body mass index, waist circumference and hypertensive status attenuated the associations, but lower HGS remained significantly associated with a higher risk of stroke. In conclusion, lower HGS was significantly associated with a higher risk of stroke independent of adiposity and hypertensive status in Mongolian adults.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43254288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-28DOI: 10.31117/neuroscirn.v4i3.74
Muhammad Zulfiqah Sadikan, Nurul Alimah Abdul Nasir, I. Iezhitsa, R. Agarwal
To evaluate the use of mirror test in an open field arena as a visual function assessment tool in a rodent model of diabetes. Male Sprague-Dawley rats were divided into diabetic rats, that received intraperitoneal streptozotocin (55 mg/kg body weight) for induction of diabetes, and control rats that similarly received citrate buffer. Rats with a blood glucose level of more than 20 mmol/L were considered diabetic. Blood glucose was monitored weekly throughout the experimental period. General behavioural assessment of the rats was done at week 12 post-induction using open field arena, followed by visual-behavioural assessment with mirror and reversed mirror added in the arena. Subsequently, rats were euthanised and subjected to haematoxylin and eosin staining (H&E) staining to assess changes in retinal morphology. In the open field test, diabetic rats showed a lesser number of zone crossings (3.73-fold, p<0.001), total distance travelled (2.02-fold, p<0.001), number of rearing episodes (2.22-fold, p<0.001) and number of grooming episodes (4.33-fold, p<0.01) but a greater number of freezing episodes (2.47-fold, p<0.001) and number of the faecal pellet (4.17-fold, p<0.01) compared to control rats. Control rats spent more time with higher zone entries toward mirrored than non-mirrored and reversed mirror zones (p<0.05 and p<0.01 respectively), whereas diabetic rats showed no preference for zones. Normal rats also showed higher freezing episodes within the mirrored zone compared to diabetic rats (2.00-fold, p<0.05). The retinal morphometry showed significant thinning of various retinal layers in the diabetic group compared to control rats. Visual behavioural activities of diabetic rats in an open field arena with the presence of a mirror could detect the presence of visual loss. Changes in visual functions positively correlated with changes in retinal morphology. Therefore, an open field mirror test could be used as an alternative for assessing visual function in the rodent model of diabetes.
{"title":"Open field mirror test as a tool for the assessment of visual functions in rats with streptozotocin-induced diabetes","authors":"Muhammad Zulfiqah Sadikan, Nurul Alimah Abdul Nasir, I. Iezhitsa, R. Agarwal","doi":"10.31117/neuroscirn.v4i3.74","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3.74","url":null,"abstract":"To evaluate the use of mirror test in an open field arena as a visual function assessment tool in a rodent model of diabetes. Male Sprague-Dawley rats were divided into diabetic rats, that received intraperitoneal streptozotocin (55 mg/kg body weight) for induction of diabetes, and control rats that similarly received citrate buffer. Rats with a blood glucose level of more than 20 mmol/L were considered diabetic. Blood glucose was monitored weekly throughout the experimental period. General behavioural assessment of the rats was done at week 12 post-induction using open field arena, followed by visual-behavioural assessment with mirror and reversed mirror added in the arena. Subsequently, rats were euthanised and subjected to haematoxylin and eosin staining (H&E) staining to assess changes in retinal morphology. In the open field test, diabetic rats showed a lesser number of zone crossings (3.73-fold, p<0.001), total distance travelled (2.02-fold, p<0.001), number of rearing episodes (2.22-fold, p<0.001) and number of grooming episodes (4.33-fold, p<0.01) but a greater number of freezing episodes (2.47-fold, p<0.001) and number of the faecal pellet (4.17-fold, p<0.01) compared to control rats. Control rats spent more time with higher zone entries toward mirrored than non-mirrored and reversed mirror zones (p<0.05 and p<0.01 respectively), whereas diabetic rats showed no preference for zones. Normal rats also showed higher freezing episodes within the mirrored zone compared to diabetic rats (2.00-fold, p<0.05). The retinal morphometry showed significant thinning of various retinal layers in the diabetic group compared to control rats. Visual behavioural activities of diabetic rats in an open field arena with the presence of a mirror could detect the presence of visual loss. Changes in visual functions positively correlated with changes in retinal morphology. Therefore, an open field mirror test could be used as an alternative for assessing visual function in the rodent model of diabetes.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44314780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-28DOI: 10.31117/neuroscirn.v4i3.77
Z. Hassan, R. Sriramaneni
A neurodegenerative disease (ND) is defined as an irreversible disorder in most cases, leading to progressive loss of neurons and intellectual abilities. ND can lead to fatality in most circumstances, and the elderly above the age of sixty-five (65) constitute the major risk category. The most common type of ND includes Alzheimer's disease (AD), and Parkinson's disease (PD). Other NDs are Huntington's disease (HD), motor neuron disease (MND), spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA), and prion disease. ND strikes mainly in the middle to late life incidence expected to rise as the population ages.
{"title":"Insights of the pathophysiology of neurodegenerative diseases and the role of phytochemical compounds in its management","authors":"Z. Hassan, R. Sriramaneni","doi":"10.31117/neuroscirn.v4i3.77","DOIUrl":"https://doi.org/10.31117/neuroscirn.v4i3.77","url":null,"abstract":"A neurodegenerative disease (ND) is defined as an irreversible disorder in most cases, leading to progressive loss of neurons and intellectual abilities. ND can lead to fatality in most circumstances, and the elderly above the age of sixty-five (65) constitute the major risk category. The most common type of ND includes Alzheimer's disease (AD), and Parkinson's disease (PD). Other NDs are Huntington's disease (HD), motor neuron disease (MND), spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA), and prion disease. ND strikes mainly in the middle to late life incidence expected to rise as the population ages.","PeriodicalId":36108,"journal":{"name":"Neuroscience Research Notes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48887073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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