Clinical Nutrition Open Science最新文献

{"title":"Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients: Results from the TransplantLines Biobank and Cohort study","authors":"Caecilia S.E. Doorenbos ,&nbsp;Adrian Post ,&nbsp;Yvonne van der Veen ,&nbsp;Casper F.M. Franssen ,&nbsp;Michele F. Eisenga ,&nbsp;Robin P.F. Dullaart ,&nbsp;Gerjan Navis ,&nbsp;Qinglin Wu ,&nbsp;Jessica M. Gonzalez-Delgado ,&nbsp;Margery A. Connelly ,&nbsp;Stephan J.L. Bakker","doi":"10.1016/j.nutos.2025.11.013","DOIUrl":"10.1016/j.nutos.2025.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplant recipients (KTR) have excess mortality compared to the general population and show altered creatine homeostasis. Creatine, an endogenous nitrogenous compound, is essential for energy metabolism. We investigated determinants of circulating creatine and their sex-specific associations with mortality in KTR.</div></div><div><h3>Methods</h3><div>Intra-erythrocyte and plasma creatine were quantified by nuclear magnetic resonance in samples from KTR and living kidney donors (healthy controls) from the TransplantLines Biobank and Cohort study (ClinicalTrials.gov: NCT03272841). Determinants of intra-erythrocyte and plasma creatine were assessed using linear regression; associations with mortality were evaluated with Cox regression.</div></div><div><h3>Results</h3><div>815 KTR and 53 healthy controls were included. Compared with controls, KTR had higher intra-erythrocyte but lower plasma creatine, with women having higher concentrations of each in both groups. In KTR, plasma creatine, BMI, erythrocyte count, reticulocyte count, lactate dehydrogenase, and erythropoietin use were positively associated with intra-erythrocyte creatine, whereas hemoglobin, haptoglobin, ferritin, transferrin saturation, proliferation inhibitor use were negatively associated. In univariable analyses, higher intra-erythrocyte creatine was associated with higher risk of mortality in male KTR (HR: 2.30 (1.50; 3.54), <em>P</em>&lt;0.001), with a weaker, nonsignificant trend in female KTR (HR: 1.51 (0.76; 3.02), <em>P</em>=0.23). Furthermore, higher plasma creatine was associated with higher risk of mortality in male KTR (HR: 1.36 (1.07; 1.73), <em>P</em>=0.01), but not in female KTR (HR: 0.94 (0.68; 1.28), <em>P</em>=0.68). These associations persisted after adjustment for potential confounders.</div></div><div><h3>Conclusion</h3><div>KTR have increased intra-erythrocyte and decreased plasma creatine compared with healthy controls. Intra-erythrocyte creatine was linked to markers of erythrocyte turnover, suggesting potential mechanisms. Elevated intra-erythrocyte and plasma creatine were associated with higher mortality in male, but not female, KTR. These findings highlight the need to further explore sex-specific mechanisms underlying creatine metabolism and clinical outcomes in KTR.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100606"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral nutrition in critically ill patients with COVID-19 in mechanical ventilation and prone position: Comparison of two enteral formulas","authors":"Gómez-Alaniz Karen Ivette ,&nbsp;Pérez-Cruz Elizabeth","doi":"10.1016/j.nutos.2025.11.002","DOIUrl":"10.1016/j.nutos.2025.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Enteral nutrition in critically ill patients with SARS-Cov-2 infection and the need for mechanical ventilation in the prone position has been a challenge.</div></div><div><h3>Methods</h3><div>An ambispective cohort study. A total of 278 analyzed patients consecutively admitted to the intensive care unit (ICU) with diagnosis of SARS-COV-2 infection by RT-PCR. The patients were divided into two groups, those who received enteral formula: a) normocaloric 1 kcal/ml and b) hypercaloric 1.5 kcal/ml. The optimal nutritional intake was defined as providing &gt;70% of the total energy requirement calculated within the first 72 hours of admission to the ICU. Gastrointestinal complications were evaluated such as reflux due to aspiration, diarrhea, abdominal distension. The aim of this study was to evaluate the optimal nutritional contribution through high-caloric vs normocaloric enteral formulas.</div></div><div><h3>Results</h3><div>The energy intake was higher in the group that received hypercaloric formulas in 97.8% vs. 73.4% of the group normocaloric formulas (p &lt;0.001). Gastrointestinal complications were lower in the group that received high-calorie formulas (p &lt;0.001). Patients with &gt; 11 SOFA points had a 2.07 times greater risk of not meeting the calculated energy requirements (p &lt; 0.05). Energy requirement per kg body actual weight for each patient was 23.0 ± 3.4 kcal/Kg/d. ICU stay, and mortality were similar in both groups.</div></div><div><h3>Conclusions</h3><div>The optimal nutritional contribution was achieved with both enteral formulas. Gradually increasing from low doses to the caloric target is safe, with high-calorie formulas being better tolerated and with fewer gastrointestinal complications.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 323-331"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C and L-arginine as potential synergistic adjuvants to recover intestinal mucositis induced by chemotherapy","authors":"Amanda Dias Borges ,&nbsp;Raquel Baumgratz Marques ,&nbsp;Luiz Octávio Pires ,&nbsp;Luísa Martins Trindade ,&nbsp;Nayara Salgado Vieira Sette ,&nbsp;Maria Emília Rabelo Andrade ,&nbsp;Samanta Thomas-Valdés ,&nbsp;Paola Caroline Lacerda Leocádio ,&nbsp;Jacqueline Isaura Alvarez-Leite ,&nbsp;Fernanda Rezende Souza ,&nbsp;Geovanni Dantas Cassali ,&nbsp;Ramon de Oliveira Souza ,&nbsp;Flaviano dos Santos Martins ,&nbsp;Valbert Nascimento Cardoso ,&nbsp;Simone de Vasconcelos Generoso ,&nbsp;Simone Odília Antunes Fernandes","doi":"10.1016/j.nutos.2025.10.013","DOIUrl":"10.1016/j.nutos.2025.10.013","url":null,"abstract":"<div><h3>Purpose</h3><div>Chemotherapy-induced intestinal mucositis is a debilitating condition often triggered by 5-fluorouracil (5-FU). This study investigated the effect of vitamin C alone and combined with L-arginine, in a murine model of 5-FU-induced mucositis.</div></div><div><h3>Methods</h3><div>Male BALB/c mice were divided into four groups: Control, Mucositis, Mucositis + Vitamin C, and Mucositis + Vitamin C + Arginine. Treatments were administered by gavage for 10 days, with mucositis induction on day 7. Clinical (body weight, food intake), histological, morphometric, immunological, oxidative stress, and gene expression parameters were evaluated.</div></div><div><h3>Results</h3><div>Mucositis significantly reduced weight and food intake (<em>P</em>&lt;0.05). Vitamin C alone enhanced anti-inflammatory effects more than combined with arginine, reducing lipid peroxidation and preserving intestinal structure. Both treatments maintained sIgA levels (<em>P</em>&lt;0.05). Notably, the combination with arginine had a synergistic effect on collagen synthesis (<em>P</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>These findings suggest that vitamin C protects against mucositis, while its combination with arginine may enhance tissue regeneration via collagen production.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 377-390"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-ICU nutrition challenge","authors":"Antonella Cotoia,&nbsp;Pierre Singer","doi":"10.1016/j.nutos.2025.11.004","DOIUrl":"10.1016/j.nutos.2025.11.004","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 321-322"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary inflammatory index and serum hs-CRP: A systematic review and meta-analysis","authors":"Sarah Al-Fayez ,&nbsp;Fatmah Othman ,&nbsp;Hadeel Al Bedewi ,&nbsp;Aiman El-Saed","doi":"10.1016/j.nutos.2025.11.003","DOIUrl":"10.1016/j.nutos.2025.11.003","url":null,"abstract":"<div><h3>Aim</h3><div>Chronic inflammation is a significant risk factor for the development of chronic diseases, including cardiovascular disease and diabetes. Increasing evidence explores the connection between the Dietary Inflammatory Index (DII) and inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP). However, results from individual studies are inconsistent; therefore, this study aims to assess the overall strength of the association between the DII and (hs-CRP) levels.</div></div><div><h3>Methods</h3><div>A systematic review was conducted following the PRISMA guidelines. Published observational studies investigating the relationship between DII and (hs-CRP) levels were sourced from MEDLINE and Web of Science. The primary outcome was the effectiveness of DII in predicting (hs-CRP) levels.</div></div><div><h3>Results</h3><div>The review included 19 observational studies with 65,929 participants from diverse populations. Seven studies qualified for meta-analysis. The pooled data demonstrated a significant positive association between DII scores and (hs-CRP) levels, suggesting that individuals with higher DII scores have an increased risk of elevated (hs-CRP), with a pooled OR of 1.42 [95% CI 1.31, 1.54, p &lt; 0.001, I2 = 0%]. Sensitivity analysis verified the stability of these findings.</div></div><div><h3>Conclusion</h3><div>Observational evidence indicates that DII could serve as a predictor for (hs-CRP) levels. Employing DII to assess the inflammatory potential of diets may assist in managing inflammation-related diseases through dietary modifications. Further research is recommended to identify optimal methods for evaluating DII and its links with health outcomes.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 343-356"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquatic foods in human health, nutrition, and overall welfare","authors":"Koshal Kumar","doi":"10.1016/j.nutos.2025.11.005","DOIUrl":"10.1016/j.nutos.2025.11.005","url":null,"abstract":"<div><div>This paper deals with the role of aquatic foods in human health, nutrition, welfare, etc. Earth is covered with 70% water, and approximately 30% of the human population lacks adequate nutrition. Aquatic foods are essential for improving human global health and nutrition levels. Japan consumes more aquatic plant and animal products than any other nation, reports the lowest rates of obesity and heart disease, and has one of the longest human life spans in the world. According to the FAO, over three billion people consume more than 20% of animal protein per person, and 4.3 billion people consume at least 15%. Aquatic foods play an essential role in the nutrition of humans and provide them with animal protein, vital amino acids, omega-3 fatty acids, vitamins, minerals, trace elements, etc. Aquatic foods from plant and animal sources provide vital nutrients to humans that promote health and prevent disease.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 332-342"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The association between dietary fat intake and benign breast diseases: a systematic review” [Clin Nutr Open Sci 62 (2025) 102–113]","authors":"Amir Hossein Faghfouri ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Sevda Saleh-Ghadimi ,&nbsp;Hamed Jafari-Vayghan","doi":"10.1016/j.nutos.2025.09.003","DOIUrl":"10.1016/j.nutos.2025.09.003","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Page 391"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network meta-analysis of the clinical efficacy of different dietary patterns in the treatment of adult metabolic dysfunction-associated steatotic liver diseases","authors":"Diwen Yu ,&nbsp;Peipei Yu ,&nbsp;Wanting Huang ,&nbsp;Pengwei Zhang ,&nbsp;Li Li","doi":"10.1016/j.nutos.2025.11.006","DOIUrl":"10.1016/j.nutos.2025.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Deipite considerable literature supports the benefits of dietary interventions for Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), the most effective dietary approach remains unclear. We conducted a systematic review and network meta-analysis (NMA) to assess the relative efficacy of different dietary approaches on improving liver function, Controlled Attenuation Parameter (CAP), body weight and Body Mass Index (BMI) in adults with MASLD.</div></div><div><h3>Methods</h3><div>We searched PubMed, the Cochrane Library, Embase and Web of Science up to March 2025 for controlled trials of different dietary approaches in adult MASLD patients. Primary outcomes were liver function and CAP, with secondary outcomes being body weight and BMI. For each outcome, the pooled effect of each intervention compared with others was determined. Mean differences (MDs) and 95% confidence intervals (95%CI) were calculated. The surface under the cumulative ranking curve (SUCRA) was used to rank dietary approaches.</div></div><div><h3>Results</h3><div>Overall, 30 trials were included, comparing five macronutrient approaches (Moderate macronutrients, Low carbohydrate (LCD), Low fat, Dietary advice, and Usual diet) and 12 dietary interventions [Atkins, DASH, Weight Watchers, Volumetrics, Low sugar diet, Low GI diet (LGID), Calorie Restriction (CR), Portfolio, Mediterranean, Low fat diet (LFD), Dietary advice, and Usual diet], involving 2051 patients. Regarding macronutrients, Moderate macronutrients demonstrated the most effective improvement in liver function (SUCRA: 76.35%); LCD proved most effective for improving both CAP (SUCRA: 91.5%) and body weight (SUCRA: 94.35%). Among dietary patterns, Portfolio was most effective for improving liver function (SUCRA: 85%), while LGID was most effective for improving CAP (SUCRA: 74.9%); The Atkins diet demonstrated the best overall improvement in body mass and BMI (SUCRA: 76.55%).</div></div><div><h3>Conclusions</h3><div>Moderate macronutrients and Portfolio diets were most effective for improving liver function, while LGID was the most effective approach for reducing CAP. The LCD and Atkins diets were considered the most effective dietary approaches for comprehensively improving body mass and BMI.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 357-376"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nutritional assessment and intervention in lung cancer radiotherapy: Current status and advances","authors":"Yangyang Gong,&nbsp;Yushu Han,&nbsp;Yiyin Liang,&nbsp;Weiwei Zhang,&nbsp;Zhen Jia,&nbsp;Liying Yang,&nbsp;Huojun Zhang","doi":"10.1016/j.nutos.2025.11.012","DOIUrl":"10.1016/j.nutos.2025.11.012","url":null,"abstract":"<div><div>Lung cancer is the leading cause of cancer-related deaths worldwide, and malnutrition during its treatment significantly impacts therapeutic outcomes and patients' quality of life. Radiotherapy, as one of the primary treatment modalities for lung cancer, often leads to a range of side effects such as nausea, esophagitis, and taste alterations, which can result in inadequate nutrient intake and sarcopenia. These conditions exacerbate treatment toxicity and increase the risk of poor prognosis. This article systematically reviews the methods of nutritional assessment, intervention strategies, and their effects on treatment toxicity and survival outcomes in lung cancer patients undergoing radiotherapy. By synthesizing existing evidence, this systematic review aims to provide a theoretical foundation for optimizing nutritional management in clinical practice, thereby improving survival outcomes and quality of life for lung cancer patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100605"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potensial effects of high protein diet on renal function in body builders in Erbil city","authors":"Muhanad Salah Mawlood","doi":"10.1016/j.nutos.2025.11.001","DOIUrl":"10.1016/j.nutos.2025.11.001","url":null,"abstract":"<div><h3>Background</h3><div>The Kidneys are known for their critical role in waste filtration and urine production, an important role of the kidney in the protein metabolism including breakdown and excretion of protein, excessive protein intake can impose significant stress on the kidneys, potentially leading to various complications.</div></div><div><h3>Aim</h3><div>aim of this study is to identify any possible health risks associated with consuming high protein diet.</div></div><div><h3>Persons and methods</h3><div>This study was cross – sectional study comprised (40) healthy participants between the ages of 18 and 48 participated. The participants were classified by two types of classification: according to protein intake per day and by duration of protein intake. (10) people were assigned to the control group, (18) athletes who consumed less than 200 grams of protein per day were assigned to the low-protein diet group, and (12) athletes who consumed more than 200 grams of protein per day were assigned to the high-protein diet group. According to duration of protein intake participants were divided into three groups: seventeen (17) participants less than five years, seven (7) participants between five to ten, and (6) participants more than 10 years of duration.</div></div><div><h3>Result</h3><div>It is clearly demonstrated statistically significant differences in mean of age (<em>p</em> = 0.003), blood urea (<em>p</em> = 0.007), serum creatinine (<em>p</em> &lt; 0.001), Urinary Albumin to Creatinine Ratio (<em>p</em> &lt; 0.001) and Urinary Protein to Creatinine Ratio (<em>p</em> &lt; 0.001) between the control group and the entire athletic (&lt;200 g/day and ≥200 g/day) groups. A highly significant differences between the means of Urinary Albumin to Creatinine Ratio (ACR) and Urinary Protein to Creatinine Ratio (PCR) between the three duration of protein intake (&lt;5, 5–10 and &gt; 10 years) groups (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The findings of this study highlight the importance of moderation in protein intake to maintain optimal renal health. While protein is a vital nutrient, excessive and prolong consumption, particularly in the context of a high-protein diet, may pose risks to kidney function.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 305-312"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}