Clinical Nutrition Open Science最新文献

{"title":"Nutritional treatment after discharge of older patients at nutritional risk: A single-arm feasibility study","authors":"Martine Kjærsgaard Nielsen ,&nbsp;Tina Munk ,&nbsp;Anne Marie Beck ,&nbsp;Jacob Rosenberg ,&nbsp;Jesper Ryg","doi":"10.1016/j.nutos.2025.10.009","DOIUrl":"10.1016/j.nutos.2025.10.009","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is common among older hospitalized patients and is linked to poor outcomes. While the transition between healthcare sectors is important for ensuring adequate nutrition, nutritional interventions have not been effectively implemented. This study aimed to evaluate the feasibility of the study design in older patients at nutritional risk following hospital discharge, focusing on eligibility, recruitment, retention, and data collection.</div></div><div><h3>Methods</h3><div>This feasibility study was conducted at Copenhagen University Hospital Herlev and Gentofte for a period of three months. Older patients at nutritional risk who were discharged with the liaison team received a food package that covered their nutritional requirements for 24 hours, along with individualized nutritional counselling provided at 2–4 days and 30 days post-discharge. The primary outcome was feasibility, assessed as eligibility, recruitment, retention, feasibility of data collection, and overall study design. The secondary outcome was compliance with nutritional counselling.</div></div><div><h3>Results</h3><div>Of 76 screened patients, 100% were eligible for participation. A total of 62 (82%) patients met the inclusion criteria and none of the exclusion criteria. During the study period, 31 (79%) accepted to participate, reflecting an inclusion rate of 1.8 patients/week. Retention in the study was 73%. Overall, data collection completeness at baseline exceeded 80%, except for three measures: nutritional risk screening by hospital staff, clinical frailty scale, and performance of 30-second chair stand test. From day 2–4 to day 30, there was an increase in the proportion of patients achieving ≥75% of their estimated requirement for energy (<em>P</em>=0.008) and protein (<em>P</em>=0.014).</div></div><div><h3>Conclusion</h3><div>Overall, the study design demonstrated that the intervention was feasible. We found high eligibility, data completeness, and compliance with the nutritional counselling in relation to energy and protein intake. However, the recruitment rate and retention in the study was lower than expected. Recruiting and retaining this nutritionally vulnerable group of older patients was challenging, and efforts must be made to secure higher retention as well as an improved recruitment strategy.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 241-254"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of bioimpedance in determining protein intake after ICU care","authors":"Cristian Deana ,&nbsp;Alessia Marin ,&nbsp;Michele Umbrello ,&nbsp;Daniele Guerino Biasucci ,&nbsp;Laura Di Meo ,&nbsp;Luigi Vetrugno","doi":"10.1016/j.nutos.2025.10.012","DOIUrl":"10.1016/j.nutos.2025.10.012","url":null,"abstract":"<div><div>Nutrition in critically ill patients after intensive care unit (ICU) discharge is frequently omitted and still poorly investigated.</div><div>Patients during ICU stay experience great muscle loss that is the main cause of ICU-acquired weakness with consequent physical disability, including difficult eating. Moreover, ICU survivors have an altered nutritional status, may present dysphagia, taste alterations and mood disorders which in turn could aggravate malnutrition.</div><div>For this purpose, body composition should be determined in critically ill patients not only during ICU stay, but also after discharge to the rehabilitation units where muscle mass could be restored with adequate nutrition and exercise.</div><div>Recent advances highlight how a personalized nutrition could optimize nutritional status in critically ill patients. Bioimpedance analysis is a useful tool to determine body composition in post-ICU period, determining lean body mass, which is the effective part of body weight metabolically active. Moreover, it could allow for a suitable protein dosage prescription optimized on lean body mass of the patient and not on a fixed amount calculated on generic formula based on body weight.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 230-240"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted literature review and assessment of evidence in microvillus inclusion disease (MVID)","authors":"Antonella Diamanti ,&nbsp;Merit Monique Tabbers ,&nbsp;Christos Tzivinikos ,&nbsp;Mohammad Saleh Miqdady ,&nbsp;Antonino Morabito ,&nbsp;Michela Pantaleoni ,&nbsp;Pravin Chaturvedi ,&nbsp;Andrea Mantovani ,&nbsp;Rithvik Badinedi ,&nbsp;Cecile Lambe","doi":"10.1016/j.nutos.2025.10.007","DOIUrl":"10.1016/j.nutos.2025.10.007","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Microvillous inclusion disease (MVID) is a rare, severe congenital disorder characterized by intractable diarrhea and life-threatening complications, including dehydration, malnutrition, intestinal failure, and eventually death. This review aims to synthesize reported evidence on MVID's clinical manifestations, treatment, and outcomes, highlighting the disease burden and identifying key gaps in current knowledge.</div></div><div><h3>Methods</h3><div>A literature review was conducted on 83 publications, including case reports and cohort studies. Studies were selected based on clinical or epidemiological data on MVID, focusing on diagnostics, treatment, and patient outcomes.</div></div><div><h3>Results</h3><div>MVID typically presents in neonates with severe diarrhea that rapidly leads to dehydration and 523 malnutrition. MVID is associated with frequent complications and high mortality (30%) reflecting the disease's severity and limitations of current treatments. Most patients remain lifelong dependent on total parenteral nutrition (TPN), increasing risks and burden. The review also revealed a lack of consistent epidemiological data and variability in clinical management.</div></div><div><h3>Discussion</h3><div>Findings underscore the need for standardized diagnostic protocols and treatment strategies. Scarcity of evidence and heterogeneity in management highlight the necessity of more comprehensive studies to improve patient outcomes.</div></div><div><h3>Conclusion</h3><div>Addressing these gaps could optimize care and reduce MVID-associated complications. Future research should focus on robust clinical guidelines and long-term data collection to improve treatment outcomes and survival rates.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 278-304"},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and determinants of malnutrition among under-five children in a specialized hospital in Bangladesh during the COVID-19 pandemic","authors":"Mukta Pasha ,&nbsp;Md. Monir Hossain Shimul ,&nbsp;Roman Hossain ,&nbsp;Salamat Khandker ,&nbsp;Salim khan ,&nbsp;Nadira Mehriban","doi":"10.1016/j.nutos.2025.10.008","DOIUrl":"10.1016/j.nutos.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Child malnutrition remains a pressing public health issue in Bangladesh, worsened by the socioeconomic consequences of the COVID-19 pandemic. Identifying nutritional status and its associated factors among children under five is critical to guide interventions.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional study was conducted from June to August 2021 at the Institute of Child and Mother Health (ICMH), Dhaka. A total of 543 children aged 6–59 months were selected using systematic random sampling. Data were collected via a pretested semi-structured questionnaire and anthropometric measurements following WHO standards. Nutritional outcomes (stunting, wasting, underweight, and MUAC) were analyzed using descriptive statistics, chi-square tests, and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Among the 543 children studied, 37.6 % were stunted, 22.8 % were underweight, and 3.9 % were wasted, with 64.3 % experiencing at least one form of malnutrition. Malnutrition was more common among males and children aged 6–12 months. Independent predictors of malnutrition included maternal underweight (BMI &lt;18.5 kg/m²; AOR = 2.87), recent diarrheal disease exposure (AOR = 5.23), and infectious disease exposure (AOR = 2.26). Children of mothers with low education (AOR = 2.37, p &lt; 0.001) and from low-income families (AOR = 2.01, p &lt; 0.001) had higher risk. Exclusive breastfeeding was protective against malnutrition (AOR = 0.39, p = 0.022). Underweight was predicted by maternal underweight (AOR = 2.58, p = 0.004), diarrheal exposure (AOR = 4.34, p &lt; 0.001), and low maternal education (AOR = 2.37, p = 0.002). Stunting was associated with low family income (AOR = 2.01, p = 0.009), maternal underweight (AOR = 2.07, p = 0.006), and exposure to diarrheal (AOR = 2.73, p = 0.001) or infectious diseases (AOR = 3.19, p &lt; 0.001). Wasting was linked to maternal underweight (AOR = 3.13, p = 0.004) and diarrheal exposure (AOR = 4.47, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The study revealed a high burden of malnutrition among hospitalized under-five children during the COVID-19 pandemic, exceeding national averages for stunting and underweight. Maternal nutrition, education, and child health exposures were key determinants. Interventions should prioritize maternal nutrition, breastfeeding promotion, and prevention of diarrheal and infectious diseases.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 192-202"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Vitamin A deficiency among children under five years attending Borama General Hospital in Borama district, awdal, Somaliland","authors":"Deka Ali Mumin ,&nbsp;Abdisamed Hashi Wais ,&nbsp;Jasiah Osiris ,&nbsp;Abdikasim Hashi Wais ,&nbsp;Shamsedin Mahdi Hassan","doi":"10.1016/j.nutos.2025.10.005","DOIUrl":"10.1016/j.nutos.2025.10.005","url":null,"abstract":"<div><div>This study investigated the determinants of vitamin A deficiency among children under five years attending Borama General Hospital in Borama District, Somaliland. Specifically, it assessed the influence of maternal knowledge, parental socio-economic status, and cultural factors on the vitamin A status of children. A cross-sectional survey was conducted with a stratified random sample of 108 mothers. Data were analysed using chi-square tests to determine associations between the selected determinants and vitamin A deficiency. The findings showed that parental socioeconomic status had a significant effect on vitamin A deficiency (χ² = 11.401, df = 4, <em>P</em> = 0.022), whereas maternal knowledge (χ² = 7.174, df = 4, <em>P</em> = 0.127) and cultural factors (χ² = 10.990, df = 2, <em>P</em> = 0.216) were not significantly associated with vitamin A status. The study concludes that household socioeconomic conditions are the primary determinants of vitamin A deficiency in children under five in Borama District. It recommends the interventions aimed at improving parental education, income, and occupation to reduce the prevalence of vitamin A deficiency and suggests further research to investigate barriers to uptake of vitamin A supplementation among mothers.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 203-211"},"PeriodicalIF":0.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bedside to beyond: The long-term impact of early mobilization in the ICU","authors":"Elisabetta Roberti ,&nbsp;Michele Bertoni ,&nbsp;Nicola Latronico ,&nbsp;Simone Piva","doi":"10.1016/j.nutos.2025.10.006","DOIUrl":"10.1016/j.nutos.2025.10.006","url":null,"abstract":"<div><div>Advances in critical care have substantially reduced intensive care unit (ICU) mortality; however, survivors frequently face long-lasting sequelae, including physical disability, cognitive decline, psychological disorders, and impaired health-related quality of life (HRQoL), collectively known as post-intensive care syndrome (PICS). Critical illness weakness (CIW) is a major contributor to the physical dimension of PICS and is associated with adverse short- and long-term outcomes. EM has been proposed as a key non-pharmacological intervention to mitigate CIW, preserve muscle mass and function, and improve patient recovery. Evidence consistently demonstrates that EM is feasible and generally safe in the ICU setting, and that it confers several short-term benefits, including improved functional independence, reduced duration of delirium, and fewer complications such as ventilator-associated pneumonia and venous thromboembolism. However, the impact of EM on long-term outcomes remains uncertain. Meta-analyses and smaller trials suggest that EM may improve patient-reported physical function at 6 months, but large randomized controlled trials and longer follow-up studies have not shown sustained improvements in objective measures of physical performance, cognitive outcomes, or HRQoL. Several factors may account for these discrepancies, including heterogeneity of mobilization protocols, variations in patient selection, limited continuation of rehabilitation after ICU discharge, and the complex multifactorial nature of long-term impairments. Integration of EM with optimal nutrition and multimodal rehabilitation strategies may hold greater promise, but robust evidence is lacking. Overall, while EM remains a cornerstone of ICU rehabilitation with clear short-term benefits, its long-term impact is less certain, underscoring the need for further high-quality, patient-centered research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 170-180"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of school meals to folate and associated nutrients intake among in-school adolescent girls in Sidama Region, Southern Ethiopia","authors":"Amelo Bolka ,&nbsp;Tafese Bosha ,&nbsp;Samson Gebremedhin","doi":"10.1016/j.nutos.2025.10.004","DOIUrl":"10.1016/j.nutos.2025.10.004","url":null,"abstract":"<div><h3>Background</h3><div>In Ethiopia limited evidence exist regarding the prevalence of inadequate dietary folate intake among adolescent girls and how the school feeding program contributes towards folate intake.</div></div><div><h3>Objective</h3><div>This study assessed contribution of school meals to folate and associated nutrients intake among in-school adolescent girls in Sidama region, Southern Ethiopia.</div></div><div><h3>Methods</h3><div>School based cross-sectional study was conducted among 700 adolescent girls. Multistage sampling method was followed to select the study participants. Multiple pass 24-hour dietary recall method was used to assess the dietary intake. Nutrient inadequacy was defined as a dietary intake below the Estimated Average Requirement (EAR). The contribution of school meals to daily nutrient intake was assessed by calculating their percentage of the Recommended Daily Allowance (RDA) for each nutrient, with an ideal target of providing two-thirds of the enrolled group's daily requirements.</div></div><div><h3>Results</h3><div>About one-fourth, 25.2% (95% CI: 21.9%, 28.4%), of the girls had inadequate folate intake. School meals contributed only 35.3% of the folate RDA for adolescent girls and 33.9% of the actual folate intake. School meals also contributed 47.3% of the iron RDA, 10% of zinc, 9.0% of vitamin C, 8.2% of vitamin A, 5.6% of calcium, and 3.7% of vitamin B-12. High prevalence of inadequacies were noted for vitamin B12 (76.7%), vitamin A (75.8%), vitamin C (66.7%), zinc (60.9%), calcium (54.7%), and iron (19%).</div></div><div><h3>Conclusion</h3><div>School meals didn't meet folate RDA. A quarter of the adolescent girls had inadequate dietary folate intake<strong>.</strong> High prevalence of dietary intake inadequacies were also found among adolescent girls. We strongly recommend revising the school meal menu and providing comprehensive nutrition education for girls and parents.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 181-191"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for malnutrition in people living with cancer and overweight or obesity: A scoping review","authors":"S. Coe ,&nbsp;T. Mitaras ,&nbsp;V. Iatridi ,&nbsp;F. Tabacchi ,&nbsp;J. Tammam ,&nbsp;E. Watson ,&nbsp;S. Wootton ,&nbsp;L. Gillespie ,&nbsp;D. Provan ,&nbsp;A. Brown ,&nbsp;N. Bibby ,&nbsp;Y.M. Goh ,&nbsp;L.J. Miller","doi":"10.1016/j.nutos.2025.10.001","DOIUrl":"10.1016/j.nutos.2025.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Current approaches to malnutrition screening in cancer pathways may not identify malnutrition in people living with overweight or obesity. The review aims to identify current screening techniques and their potential validity in people living overweight or obesity and cancer.</div></div><div><h3>Methods</h3><div>PubMed, Medline and CINAHL were searched for English-language publications reporting data from malnutrition screening tools in adults with cancer living with overweight or obesity. These included 1) diagnostic accuracy studies with validity analysis against a reference, 2) comparative studies, without validity analysis, and 3) monomethod studies of single malnutrition screening tools. Registered in Open Science Framework. (<span><span>https://doi.org/10.17605/OSF.IO/ZWFBM</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>3705 records were identified with 16 full-text papers included. Eleven tools and measures were used to screen for malnutrition in people living with overweight or obesity and cancer. These included questionnaires (Malnutrition Universal Screening Tool; Malnutrition Screening Tool; Patient Generated Subjective Global Assessment (original/Short Form); Nutrition Risk Screening-2002; Short Nutritional Assessment Questionnaire and its variations; Mini Nutrition Assessment-Short Form), an algorithm-based tool (Nutrition Risk Index), and handgrip strength measures.</div></div><div><h3>Discussion</h3><div>There is a lack of consensus on the most appropriate tool, though combining subjective and objective measures may improve malnutrition screening in people with cancer and overweight or obesity.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 212-229"},"PeriodicalIF":0.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frequency of seaweed intake and frailty in Japanese elderly men and women: A cross-sectional study","authors":"Han Seungah ,&nbsp;Masayoshi Ishida ,&nbsp;Yoshino Murakami ,&nbsp;Motoyuki Iemitsu ,&nbsp;Oh Taewoong ,&nbsp;Kiyoshi Sanada","doi":"10.1016/j.nutos.2025.10.003","DOIUrl":"10.1016/j.nutos.2025.10.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Seaweed is rich in minerals, vitamins, fibers, and protein, suggesting that intake of high levels of seaweed might contribute to a lower prevalence of frailty. Accordingly, the present study aimed to examine the association between seaweed intake and pre-frailty in elderly Japanese men and women.</div></div><div><h3>Methods</h3><div>This cross-sectional study collected data from 109 elderly individuals aged 65–90 years living in Oga City, Japan. Seaweed intake was assessed using a brief self-administered diet history questionnaire (BDHQ), and participants were classified into two groups (i.e., High Intake (HI) group and Low Intake (LI) group) according to weekly intake frequency. A binary logistic regression model was used to examine the relationship between seaweed intake and pre-frailty.</div></div><div><h3>Results</h3><div>The HI group had a lower body weight and BMI compared to the LI group. Additionally, the HI group showed faster gait speed and Timed Up and Go (TUG) performance, as well as a greater distance in the 2-step test (<em>p</em> &lt; .01), compared to the LI group. Seaweed intake was inversely associated with physical pre-frailty and cognitive frailty, while no association was found with social pre-frailty.</div></div><div><h3>Conclusion</h3><div>Seaweed intake was significantly and inversely associated with physical pre-frailty and cognitive frailty, suggesting that high seaweed intake may be beneficial against frailty in elderly men and women.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 161-169"},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating phase angle in malnutrition risk assessment using nutritional screening tools","authors":"Damla Zeynep Bayraktar ,&nbsp;Serap Andac ,&nbsp;Negin Elmas","doi":"10.1016/j.nutos.2025.10.002","DOIUrl":"10.1016/j.nutos.2025.10.002","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Malnutrition is a common complication in patients with breast cancer and is associated with adverse clinical outcomes. Phase angle (PhA), a parameter derived from bioelectrical impedance analysis (BIA) may reflect nutritional status, but its value versus standard tools remains unclear. This study aims to evaluate the utility of PhA in detecting malnutrition risk in breast cancer patients, compared with four validated screening tools.</div></div><div><h3>Methods</h3><div>This cross-sectional observational study included 98 female patients with breast cancer. Nutritional status was assessed using the Nutritional Risk Screening 2002 (NRS-2002), Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF), Malnutrition Universal Screening Tool (MUST), and Malnutrition Screening Tool (MST). PhA was measured using single-frequency (50 kHz) BIA. Receiver Operating Characteristic (ROC) analysis was used to determine the optimal PhA cut-off for malnutrition risk. Associations between PhA and malnutrition risk were examined univariate and multivariate logistic regression analyses.</div></div><div><h3>Results</h3><div>PhA was significantly associated with nutritional risk across all four screening tools. The optimal PhA cut-off for malnutrition risk based on NRS-2002 was 5.04 degrees (AUC = 0.83), with 73% sensitivity and 87% specificity. In crude logistic regression, a PhA &lt;5.04 degrees significantly increased malnutrition risk across all screening tools: NRS-2002 (OR = 0.178, p &lt; 0.001), MUST (OR = 0.338, p = 0.005), MST (OR = 0.308, p &lt; 0.001), and PG-SGA SF (OR = 0.481, p = 0.037). These associations remained statistically significant after adjustment for age and fat mass index in three models (excluding PG-SGA SF).</div></div><div><h3>Conclusion</h3><div>PhA, appears to be a practical and supportive indicator for identifying malnutrition risk in breast cancer patients, particularly when used alongside validated screening tools. The identified cut-off value (5.04 degrees) may serve as a useful threshold in clinical practice.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 147-160"},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}