Clinical Nutrition Open Science最新文献_第6页

Accuracy of resting energy expenditure predictive equations in coronavirus disease 2019 (COVID-19) survivors 2019年冠状病毒病（COVID-19）幸存者静息能量消耗预测方程的准确性

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-11 DOI: 10.1016/j.nutos.2024.10.007

Montserrat Montes-Ibarra , Camila L.P. Oliveira , Taiwo Olobatuyi , Maria Cristina Gonzalez , Richard Thompson , D. Ian Paterson , Carla M. Prado

Background & Aims

Coronavirus disease 2019 (COVID-19) may be associated with abnormal energy metabolism and lead to inaccurate resting energy expenditure (REE) estimations by predictive equations. Here, we report measured REE (mREE) of a group of COVID-19 survivors and compared its accuracy against predicted REE (pREE).

Methods

This was a cross-sectional analysis of patients who survived COVID-19 prior to July 2021. An indirect calorimeter was used for mREE and compared against 21 pREE equations, 10 of which used a measure of body composition. Paired t-tests and Bland-Altman analysis were used to evaluate agreement and relative accuracy or bias for percentage error between pREE and mREE; measurements within ±10% were considered accurate.

Results

We assessed 38 COVID-19 survivors; age: 48.5y (interquartile range: 40.2, 60.0), body mass index: 29.3±5.6 kg/m², mREE: 1520± 275 kcal/d, time since COVID-19: 183.2 ±34.4 days. Ten (47.6%) pREE equations were significantly different from mREE (P <0.05). Harris-Benedict equation had the smallest limits of agreement, ranging from -14.3% to 25.8% (or -249 to 393 kcal/d). Mifflin St-Jeor was the most accurate equation (within 10% of mREE). The best performing equation (Mifflin St-Jeor) still over or under-estimated pREE in ∼37% of the patients.

Conclusion

A large variability in mREE versus pREE was observed in COVID-19 survivors. Even the most accurate equation (Mifflin St-Jeor) exhibited higher inaccuracies compared to mREE. We need to explore better methods to estimate energy requirements during the COVID-19 recovery period, until more accurate predictive equations are developed this population.

背景& 目的2019年冠状病毒病（COVID-19）可能与能量代谢异常有关，并导致预测方程对静息能量消耗（REE）的估计不准确。在此，我们报告了一组 COVID-19 幸存者的测量 REE（mREE），并将其准确性与预测 REE（pREE）进行了比较。使用间接热量计计算 mREE，并与 21 种 pREE 方程进行比较，其中 10 种使用了身体成分测量方法。使用配对 t 检验和 Bland-Altman 分析来评估 pREE 和 mREE 之间的一致性以及百分比误差的相对准确性或偏差；测量结果在 ±10% 以内视为准确：体重指数：29.3±5.6 kg/m2，mREE：1520±275 kcal/d，自 COVID-19 后的时间：183.2 ±34.4 天：183.2±34.4天。10个（47.6%）pREE方程与 mREE 有显著差异（P <0.05）。哈里斯-本尼迪克特方程的一致性范围最小，从-14.3%到25.8%（或-249到393千卡/天）不等。Mifflin St-Jeor 是最准确的方程（mREE 的 10%以内）。结论在 COVID-19 存活者中观察到 mREE 与 pREE 之间存在很大差异。即使是最准确的方程（Mifflin St-Jeor）也显示出比 mREE 更高的不准确性。我们需要探索更好的方法来估算 COVID-19 恢复期的能量需求，直到开发出更准确的预测公式。

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引用次数: 0

Prediabetes detection in unconstrained conditions using wearable sensors 利用可穿戴传感器在无限制条件下检测糖尿病前期症状

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-11 DOI: 10.1016/j.nutos.2024.09.013

Dimitra Tatli , Vasileios Papapanagiotou , Aris Liakos , Apostolos Tsapas , Anastasios Delopoulos

Prediabetes is a common health condition that often goes undetected until it progresses to type 2 diabetes. Early identification of prediabetes is essential for timely intervention and prevention of complications. This research explores the feasibility of using wearable continuous glucose monitoring along with smartwatches with embedded inertial sensors to collect glucose measurements and acceleration signals respectively, for the early detection of prediabetes. We propose a methodology based on signal processing and machine learning techniques. Two feature sets are extracted from the collected signals, based both on a dynamic modeling of the human glucose-homeostasis system and on the Glucose curve, inspired by three major glucose related blood tests. Features are aggregated per individual using bootstrap. Support Vector Machines are used to classify normoglycemic vs. prediabetic individuals. We collected data from 22 participants for evaluation. The results are highly encouraging, demonstrating high sensitivity and precision. This work is a proof of concept, highlighting the potential of wearable devices in prediabetes assessment. Future directions involve expanding the study to a larger, more diverse population and exploring the integration of CGM and smartwatch functionalities into a unified device. Automated eating detecting algorithms can also be used.

糖尿病前期是一种常见的健康问题，在发展为 2 型糖尿病之前往往不被发现。早期识别糖尿病前期对及时干预和预防并发症至关重要。本研究探讨了使用可穿戴连续葡萄糖监测仪和带有嵌入式惯性传感器的智能手表分别收集葡萄糖测量值和加速度信号以早期检测糖尿病前期的可行性。我们提出了一种基于信号处理和机器学习技术的方法。我们从收集到的信号中提取了两个特征集，这两个特征集基于人体葡萄糖平衡系统的动态建模和葡萄糖曲线，其灵感来源于三种主要的葡萄糖相关血液测试。使用引导法对每个人的特征进行汇总。使用支持向量机对血糖正常者和糖尿病前期者进行分类。我们收集了 22 名参与者的数据进行评估。结果非常令人鼓舞，显示出较高的灵敏度和精确度。这项工作是一个概念验证，凸显了可穿戴设备在糖尿病前期评估中的潜力。未来的研究方向包括将研究扩大到更大规模、更多样化的人群，并探索将 CGM 和智能手表的功能整合到一个统一的设备中。还可以使用自动进食检测算法。

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引用次数: 0

Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products 烤腰果补充剂对暴露于混合馏分石油产品的高血压大鼠内皮肾血管收缩疾病的干预作用

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-11 DOI: 10.1016/j.nutos.2024.10.005

J.K. Akintunde , A.O. Okunubi , O.A. Dosumu , A.T. Omidiran , A.D. Folayan , S.O. Salami

There have been increasing concerns about the great risks posed by petroleum products which contribute to the progression endothelial renal vasoconstriction and hypertension. This study aims to investigate the modulatory effects of Roasted cashew nut on rats induced with endothelial renal vasoconstriction syndrome upon exposure to mixed fractionated petroleum products (MFPP). Seventy male albino rats were randomized into seven (n=10) groups. Group I (normal control) was given distilled water. Group II was administered with MFPP (20 %/day). Group III was administered with MFPP (20 %/day) + atenolol (50 mg/kg). Group IV was administered with MFPP (20 %/day) + 10 % roasted cashew nut (10 %RCN). Group V was administered with MFPP (20 %/day) + (20 %RCN). Group VI was treated with 10 %RCN while Group VII was treated with 20 %RCN. Data were analyzed using one-way analysis of variance (ANOVA) and Duncan's multiple range test with P<0.05 considered significant. Oral RCN intervention prohibited endothelial renal vasoconstriction syndrome and hypertension by down-regulating the pro-inflammatory cytokines including IL-10, TNF-α, HIF-1, MCP-1 and p53 with a concomitant inhibition of the activities of arginase, phosphodiesterase-5¹ (PDE-5¹) and angiotensin converting enzyme (ACE). Furthermore, endothelial renal vasoconstriction syndrome was pointedly abrogated by treatment with RCN as depicted by the reduced activities of the enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA), AChE and MAO-A with a subsequent upsurge in the level of NO while the histological derangements caused by MFPP were completely abated. This study thus authenticates the proposition that RCN may be a valuable therapy in ameliorating apoptosis, renal pro-inflammatory cytokines and enzymes of ATP-hydrolysis in endothelial renal vasoconstriction syndrome and hypertensive rat model on exposure to MFPP.

人们越来越关注石油产品造成的巨大风险，因为石油产品会导致内皮肾血管收缩和高血压。本研究旨在探讨烤腰果对暴露于混合馏分石油产品（MFPP）后诱发内皮肾血管收缩综合征的大鼠的调节作用。将 70 只雄性白化大鼠随机分为 7 组（n=10）。I 组（正常对照组）给予蒸馏水。第二组服用中链氯化石蜡（20%/天）。第三组服用 MFPP（20%/天）+ 阿替洛尔（50 毫克/千克）。第四组：MFPP（20%/天）+ 10%烤腰果（10%RCN）。第五组：MFPP（20%/天）+（20%RCN）。第六组施用 10 %RCN，第七组施用 20 %RCN。数据采用单因素方差分析（ANOVA）和邓肯多重范围检验进行分析，P<0.05 为显著性。口服 RCN 通过下调促炎细胞因子，包括 IL-10、TNF-α、HIF-1、MCP-1 和 p53，同时抑制精氨酸酶、磷酸二酯酶-51 (PDE-51) 和血管紧张素转换酶 (ACE) 的活性，从而抑制内皮肾血管收缩综合征和高血压。此外，ATP水解酶（ATP酶、ADP酶、AMP酶和ADA）、乙酰胆碱酯酶（AChE）和MAO-A的活性降低，NO的水平随之升高，而MFPP引起的组织学变化则完全缓解，由此可见，RCN治疗可明显缓解内皮肾血管收缩综合征。因此，本研究证实了 RCN 可能是一种有价值的疗法，可改善内皮肾血管收缩综合征和高血压大鼠模型暴露于 MFPP 时的细胞凋亡、肾促炎细胞因子和 ATP- 水解酶。

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引用次数: 0

The association between early postoperative food intake and postoperative hospital length of stay in patients undergoing cardiac surgery: A retrospective observational single-center study 心脏手术患者术后早期食物摄入量与术后住院时间的关系：单中心回顾性观察研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-11 DOI: 10.1016/j.nutos.2024.10.003

Eri Natsuhori , Takeshi Unoki

Background & Aims

Perioperative nutritional status is critical during the postoperative recovery process in patients undergoing cardiac surgery. Several studies on patients undergoing cardiac surgery have reported low energy intake in early postoperative food intake via oral nutrition; however, no study has shown an association of low energy intake with postoperative hospital length of stay (LOS). This study aimed to determine whether early postoperative low food intake was associated with prolonged postoperative hospital LOS in patients undergoing cardiac surgery.

Methods

This was a retrospective, observational, singlecenter study conducted in patients aged ≥18 years undergoing elective cardiac surgery from January 1, 2020, to May 31, 2023. Patients were categorized by food intake as food intake < 50% (low food intake group) and ≥ 50% (adequate food intake group) at lunch on postoperative day (POD) 3. The primary outcome of this study was the postoperative hospital LOS. A generalized linear model was used to examine the association between food intake and postoperative hospital LOS using the following explanatory variables: age, European System for Cardiac Operative Risk Evaluation (EuroSCORE) II value, preoperative risk of malnutrition, activities of daily living status, Sequential Organ Failure Assessment score, and C-reactive protein level.

Results

Of the 315 patients, 104 (33.0%) had a food intake of <50% on POD3. There were no significant differences in age, sex, EuroSCORE II value, and comorbidities between the two groups. Patients in the low-food intake group had a significantly lower Barthel Index (6.7% vs. 1.4%, p = 0.017) and a higher malnutrition risk according to the Mini Nutritional Assessment Short Form score (40.4% vs. 28.2%, p = 0.043). Food intake of <50% on POD3 was associated with prolonged postoperative hospital LOS (β = 1.135 [95% confidence interval: 1.004–1.262], p = 0.018).

Conclusions

Low food intake on POD3 is associated with prolonged postoperative hospital LOS in patients undergoing elective cardiac surgery. Early postoperative food intake should be closely monitored in patients after elective cardiac surgery.

背景& 目的在心脏手术患者的术后恢复过程中，围手术期的营养状况至关重要。多项关于心脏手术患者的研究报告称，术后早期通过口服营养摄入的食物能量摄入量较低；但是，没有研究表明能量摄入量低与术后住院时间（LOS）有关。本研究旨在确定接受心脏手术的患者术后早期低食物摄入是否与术后住院时间延长有关。方法这是一项回顾性、观察性、单中心研究，研究对象是 2020 年 1 月 1 日至 2023 年 5 月 31 日期间接受择期心脏手术的年龄≥18 岁的患者。根据术后第 3 天（POD）午餐时的食物摄入量，将患者分为食物摄入量< 50%（食物摄入量低组）和≥50%（食物摄入量充足组）。采用广义线性模型研究了食物摄入量与术后住院时间之间的关系，并使用了以下解释变量：年龄、欧洲心脏手术风险评估系统（EuroSCORE）II值、术前营养不良风险、日常生活活动状况、序贯器官功能衰竭评估评分和C反应蛋白水平。两组患者在年龄、性别、EuroSCORE II 值和合并症方面无明显差异。低食物摄入组患者的巴特尔指数（Barthel Index）明显较低（6.7% 对 1.4%，P = 0.017），根据迷你营养评估简表评分，营养不良风险较高（40.4% 对 28.2%，P = 0.043）。POD3的食物摄入量为<50%与术后住院时间延长有关（β = 1.135 [95%置信区间：1.004-1.262]，p = 0.018）。应密切监测择期心脏手术患者术后早期的食物摄入量。

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引用次数: 0

Cancer predictive model derived from bioimpedance measurements using machine learning methods 利用机器学习方法从生物阻抗测量中得出癌症预测模型

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-11 DOI: 10.1016/j.nutos.2024.10.006

José Luis García Bello , Taira Batista Luna , Agustín Garzón Carbonell , Ana de la Caridad Román Montoya , Alcibíades Lara Lafargue , Héctor Manuel Camué Ciria , Yohandys A. Zulueta

Objective

This work is aimed to develop a machine learning predictions of health status derived from bioimpedance measurements of adult healthy and cancer individuals.

Methods

We conducted a pilot random study containing 2881 female (1220) and male (1661) patients ranging in age between 19 to 96 years old are studied. Among of them, 33 are diagnosed with cancer disease, the rest are healthy. After balancing the initial data, the data of interest contains 1.460 individuals ranging in age between 19 and 93 years old (734 female and 726 male), with 704 diagnosed with cancer and 756 healthy, respectively. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. The bioimpedance analyser (BioScan98®) is used, collecting fundamental bioelectrical and other parameters of interest. A classification model are performed, followed by a prediction of phase angle and body mass index.

Results

The classification model reveal two robust parameters for predicting the health status, namely the impedance, the total body water and the phase angle with a 97%, 34% and 30 % of significance (respectively), with an area under the receiver operating characteristic curve of AUC = 1.00. The phase angle predictions agrees with previous reports of other type of pathologies, where higher phase angle values is ascribed to better health status and male have larger values than female. Recommendations regarding the capacitive reactance as a robust parameter to inferring health status is discussed. The cubic support vector machine model shows great accuracy predicting the nutritional status based on body mass index of both healthy and cancer patients.

Conclusion

The classification, phase angle and body mass index predictive models developed in this work are of the great importance to assist the diagnosis, differentiating between healthy and cancer individual with great accuracy. Despite the moderate lack of body mass index association with cancer, this model can be used for prompt diagnosis.

方法我们进行了一项试验性随机研究，研究对象包括 2881 名女性（1220 名）和男性（1661 名）患者，年龄在 19 岁至 96 岁之间。其中，33 人确诊患有癌症，其余均为健康人。平衡初始数据后，相关数据包含 1.460 名年龄在 19 至 93 岁之间的患者（女性 734 人，男性 726 人），其中 704 人确诊为癌症，756 人健康。生物阻抗参数是通过测量标准四极全身配置获得的。使用生物阻抗分析仪（BioScan98®）收集基本生物电参数和其他相关参数。结果分类模型揭示了两个预测健康状况的可靠参数，即阻抗、身体总水分和相位角，其显著性分别为 97%、34% 和 30%，接收者工作特征曲线下面积 AUC = 1.00。相位角的预测结果与之前关于其他病理类型的报告一致，相位角值越高，健康状况越好，男性的相位角值比女性大。讨论了将电容电抗作为推断健康状况的稳健参数的建议。结论本研究中开发的分类、相位角和体重指数预测模型对于辅助诊断、准确区分健康人和癌症患者具有重要意义。尽管身体质量指数与癌症的关联度不高，但该模型仍可用于及时诊断。

{"title":"Cancer predictive model derived from bioimpedance measurements using machine learning methods","authors":"José Luis García Bello , Taira Batista Luna , Agustín Garzón Carbonell , Ana de la Caridad Román Montoya , Alcibíades Lara Lafargue , Héctor Manuel Camué Ciria , Yohandys A. Zulueta","doi":"10.1016/j.nutos.2024.10.006","DOIUrl":"10.1016/j.nutos.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>This work is aimed to develop a machine learning predictions of health status derived from bioimpedance measurements of adult healthy and cancer individuals.</div></div><div><h3>Methods</h3><div>We conducted a pilot random study containing 2881 female (1220) and male (1661) patients ranging in age between 19 to 96 years old are studied. Among of them, 33 are diagnosed with cancer disease, the rest are healthy. After balancing the initial data, the data of interest contains 1.460 individuals ranging in age between 19 and 93 years old (734 female and 726 male), with 704 diagnosed with cancer and 756 healthy, respectively. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. The bioimpedance analyser (BioScan98®) is used, collecting fundamental bioelectrical and other parameters of interest. A classification model are performed, followed by a prediction of phase angle and body mass index.</div></div><div><h3>Results</h3><div>The classification model reveal two robust parameters for predicting the health status, namely the impedance, the total body water and the phase angle with a 97%, 34% and 30 % of significance (respectively), with an area under the receiver operating characteristic curve of AUC = 1.00. The phase angle predictions agrees with previous reports of other type of pathologies, where higher phase angle values is ascribed to better health status and male have larger values than female. Recommendations regarding the capacitive reactance as a robust parameter to inferring health status is discussed. The cubic support vector machine model shows great accuracy predicting the nutritional status based on body mass index of both healthy and cancer patients.</div></div><div><h3>Conclusion</h3><div>The classification, phase angle and body mass index predictive models developed in this work are of the great importance to assist the diagnosis, differentiating between healthy and cancer individual with great accuracy. Despite the moderate lack of body mass index association with cancer, this model can be used for prompt diagnosis.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 131-145"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longer sitting times and bulk amounts of rice intake are associated with the increased risks of metabolic dysfunction-associated fatty liver diseases (MAFLD): A case-control study 久坐和大量摄入米饭与代谢功能障碍相关脂肪肝（MAFLD）的风险增加有关：一项病例对照研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-09 DOI: 10.1016/j.nutos.2024.10.002

Shahinul Alam , Mahbuba Kawser , Saif Uddin Nisar Ahmed , Md Mahabubul Alam , Md Saiful Islam , Shayla Nasrin

Background and aims

One-third of the country suffers from metabolic dysfunction-associated fatty liver disease (MAFLD) due to unhealthy, improper dietary habits and sedentary lifestyles. This study aimed to explore the specific diet and lifestyle factors responsible for MAFLD.

Methods

This case-control study was conducted among the source population (n=200 diagnosed with MAFLD criteria; n=100 healthy controls). Quantitative approaches, such as interviews, were applied to measure dietary practices and physical activity levels.

Results

Most (89.5%) of the MAFLD patients were obese, used to sedentary lifestyles (56.0%), and took outside foods (58.5%) than their counterparts (P<0.001). Moreover, nutrient intake analysis/day depicted that MAFLD patients consumed significantly higher amounts of total energy (2288.8 vs. 1570.8 kcal/day), calories from rice (1003.6 vs.795.2 Kcal/day), carbs (335.2 vs. 198.8 g/day), protein (97.9 vs. 85.9 g/day), fat (61.8 vs. 48.0 g/day) than controls. Nevertheless, 86.5% of MAFLD patients consumed a surplus of +268.6 kcal/day, indicating energy was not burnt through physical activities, while 89.0% of controls have negative energy balance (-360.4 kcal/day). Multivariable analyses revealed that >300 minutes sitting times (aOR=8.6), >300 g/day carbohydrate consumption (aOR=6.9), >950 kcal/day from rice (aOR=2.2), >50 g/day fat (aOR=2.9), ≤2000 Kcal/day energy-expenditure (aOR=2.9), BMI >25 kg/m² (Adjusted odds ratio=aOR=16.1), eating outside (aOR=7.4), being housewives (aOR=4.89), service-holders (aOR=4.12), >31 age group (aOR=2.9), are significant risk factors for MAFLD.

Conclusion

Longer sitting times, outside eating habits, more energy from carbohydrates, especially rice, and a daily positive energy balance lead to obesity and, consequently, an increased risk of MAFLD.

背景和目的由于不健康、不正确的饮食习惯和久坐不动的生活方式，我国有三分之一的人患有代谢功能障碍相关性脂肪肝（MAFLD）。本研究旨在探讨导致代谢功能障碍相关性脂肪肝的具体饮食和生活方式因素。方法本病例对照研究在来源人群中进行（诊断为代谢功能障碍相关性脂肪肝标准的人数=200；健康对照组人数=100）。结果大多数（89.5%）MAFLD 患者肥胖，习惯久坐不动的生活方式（56.0%），并比同类患者多吃外界食物（58.5%）（P<0.001）。此外，营养素摄入分析表明，MAFLD 患者每天摄入的总能量（2288.8 千卡/天 vs. 1570.8 千卡/天）、米饭热量（1003.6 千卡/天 vs. 795.2 千卡/天）、碳水化合物（335.2 克/天 vs. 198.8 克/天）、蛋白质（97.9 克/天 vs. 85.9 克/天）、脂肪（61.8 克/天 vs. 48.0 克/天）明显高于对照组。然而，86.5%的MAFLD患者每天摄入的能量盈余为+268.6千卡，这表明能量没有通过体力活动消耗掉，而89.0%的对照组患者的能量平衡为负（-360.4千卡/天）。多变量分析表明，坐 300 分钟（aOR=8.6）、每天摄入 300 克碳水化合物（aOR=6.9）、每天从米饭中摄入 950 千卡热量（aOR=2.2）、>50 克/天脂肪（aOR=2.9）、≤2000 千卡/天能量消耗（aOR=2.9）、体重指数（BMI）>25 千克/平方米（调整后的几率比=aOR=16.1）、在外就餐（aOR=7.结论久坐时间长、外出就餐习惯、更多能量来自碳水化合物（尤其是米饭）以及每日正能量平衡会导致肥胖，进而增加罹患 MAFLD 的风险。

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引用次数: 0

Low-caffeine green tea supplementation reduced lithium serum levels and the relative abundance of microbiota in women with obesity: A case study 补充低咖啡因绿茶可降低肥胖女性的锂血清水平和微生物群的相对丰度：案例研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-05 DOI: 10.1016/j.nutos.2024.09.012

Natália Yumi Noronha , Guilherme da Silva Rodrigues , Vanessa Fernandes Rodrigues , Carolina Ferreira Nicoletti , Luzânia dos Santos Martins , Luísa Maria Diani , Heitor Bernardes Pereira Delfino , Marcela Augusta de Souza Pinhel , Lígia Moriguchi Watanabe , Wellington Tavares de Sousa Júnior , Déborah Araújo Morais , Fernando Barbosa Júnior , Fabiani Gai Frantz , Daniela Carlos , Carla Barbosa Nonino

Background

Green tea (GT) polyphenols play an important and known role in the oxidative and inflammatory response due to their antioxidant, anti-inflammatory, anti-hyperglycemic, and anti-obesity properties. However, its relation to the detoxification of toxic metals and its possible effect remains unknown.

Purpose

The present study investigated the relationship between GT intake, toxic metals detoxification, and gut microbiota in obesity.

Methods

Each participant in the group initially received 56 capsules of low-caffeine GT from the Solaray® brand. After four weeks of supplementation, another 56 capsules were given, totaling 112. All assessments were performed pre- and post-GT intervention. Serum metal levels were determined using an inductively coupled plasma mass spectrometer (PerkinElmer, NexION 2000 B, Waltham, MA, EUA, EUA). Fecal DNA was extracted using the QIAmp® Fast DNA Stool MiniKit (QIAGEN).

Results

Intervention with GT did not promote changes in the clinical or metabolic data evaluated. However, GT supplementation led to a significant decrease of 48% in Lithium concentration in the post-intervention period compared to the pre-intervention period. This study also observes the prebiotic effect of green tea in modulating Bacteroidetes and Firmicutes.

Conclusions

The GT effect of Lithium reduction is a new finding in the literature. There is a lack of investigation to address the effects of the components of the GT in lithium excretion, and we attribute this effect to the trace amount of caffeine.

背景绿茶（GT）多酚因其抗氧化、抗炎、抗高血糖和抗肥胖的特性，在氧化和炎症反应中发挥着重要的已知作用。本研究调查了GT摄入量、有毒金属解毒和肥胖症肠道微生物群之间的关系。方法研究组的每位参与者最初服用56粒Solaray®品牌的低咖啡因GT胶囊。经过四周的补充后，再服用 56 粒，共计 112 粒。所有评估均在GT干预前后进行。使用电感耦合等离子体质谱仪（PerkinElmer，NexION 2000 B，Waltham，MA，EUA，EUA）测定血清金属含量。使用 QIAmp® Fast DNA Stool MiniKit（QIAGEN）提取粪便 DNA。但是，与干预前相比，补充 GT 后，干预后的锂浓度显著下降了 48%。本研究还观察到绿茶在调节类杆菌和固缩菌方面的益生作用。目前还缺乏针对 GT 成分对锂排泄影响的研究，我们将这种影响归因于微量咖啡因。

{"title":"Low-caffeine green tea supplementation reduced lithium serum levels and the relative abundance of microbiota in women with obesity: A case study","authors":"Natália Yumi Noronha , Guilherme da Silva Rodrigues , Vanessa Fernandes Rodrigues , Carolina Ferreira Nicoletti , Luzânia dos Santos Martins , Luísa Maria Diani , Heitor Bernardes Pereira Delfino , Marcela Augusta de Souza Pinhel , Lígia Moriguchi Watanabe , Wellington Tavares de Sousa Júnior , Déborah Araújo Morais , Fernando Barbosa Júnior , Fabiani Gai Frantz , Daniela Carlos , Carla Barbosa Nonino","doi":"10.1016/j.nutos.2024.09.012","DOIUrl":"10.1016/j.nutos.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Green tea (GT) polyphenols play an important and known role in the oxidative and inflammatory response due to their antioxidant, anti-inflammatory, anti-hyperglycemic, and anti-obesity properties. However, its relation to the detoxification of toxic metals and its possible effect remains unknown.</div></div><div><h3>Purpose</h3><div>The present study investigated the relationship between GT intake, toxic metals detoxification, and gut microbiota in obesity.</div></div><div><h3>Methods</h3><div>Each participant in the group initially received 56 capsules of low-caffeine GT from the Solaray® brand. After four weeks of supplementation, another 56 capsules were given, totaling 112. All assessments were performed pre- and post-GT intervention. Serum metal levels were determined using an inductively coupled plasma mass spectrometer (PerkinElmer, NexION 2000 B, Waltham, MA, EUA, EUA). Fecal DNA was extracted using the QIAmp® Fast DNA Stool MiniKit (QIAGEN).</div></div><div><h3>Results</h3><div>Intervention with GT did not promote changes in the clinical or metabolic data evaluated. However, GT supplementation led to a significant decrease of 48% in Lithium concentration in the post-intervention period compared to the pre-intervention period. This study also observes the prebiotic effect of green tea in modulating <em>Bacteroidetes</em> and <em>Firmicutes</em>.</div></div><div><h3>Conclusions</h3><div>The GT effect of Lithium reduction is a new finding in the literature. There is a lack of investigation to address the effects of the components of the GT in lithium excretion, and we attribute this effect to the trace amount of caffeine.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 252-264"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the barriers to diagnosing malnutrition in patients with cancer: A study on oncologists' perspectives 探索诊断癌症患者营养不良的障碍：关于肿瘤学家观点的研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-10-05 DOI: 10.1016/j.nutos.2024.10.001

Lisa Heide Koteng , Kari Sand , Ingvild Paur , Asta Bye , Bente Ervik , Tora S. Solheim , Inger Ottestad , Trude R. Balstad

Background and aim

Patients with cancer are at high risk of malnutrition, yet relevant ICD-10 codes for malnutrition are underutilized in cancer clinics. Understanding oncologists' perspectives is crucial for optimizing malnutrition diagnosis codes and enhancing nutritional practices to improve patient care. This study aims to explore oncologists' perspectives on the use and feasibility of the ICD-10 codes for malnutrition.

Methods

A qualitative study was conducted, consisting of four focus group interviews with oncologists (n=14) from three Norwegian hospitals. A semi-structured interview guide, covering five main topics, guided the discussions.

Results

Few oncologists were familiar with the malnutrition diagnosis codes. The codes were considered inapplicable in clinical practice, partly due to complex diagnostic criteria. None used the codes systematically, instead relying on inquiries about patients' weight, weight loss, food intake, and appetite. Oncologists prioritized identifying patients in need of nutritional treatment, considering diagnosis codes unnecessary for providing quality care. Proposals for increased code utilization included economic incentives, enhanced collaboration with clinical dietitians, and digital systems for automated coding.

Conclusion

The oncologists expressed that they prevent and treat malnutrition in patients with cancer, but not systematically. They do not utilize ICD-10 codes for malnutrition, citing both complex diagnostic criteria and the codes’ lack of relevance to nutritional treatment as limiting factors.

背景和目的癌症患者营养不良的风险很高，但在癌症诊所中，相关的 ICD-10 营养不良代码却未得到充分利用。了解肿瘤学家的观点对于优化营养不良诊断代码和加强营养实践以改善患者护理至关重要。本研究旨在探讨肿瘤学家对营养不良ICD-10编码的使用和可行性的看法。研究方法：本研究采用定性研究方法，对来自挪威三家医院的肿瘤学家（人数=14）进行了四次焦点小组访谈。结果几乎没有肿瘤学家熟悉营养不良诊断代码。他们认为这些代码在临床实践中并不适用，部分原因是诊断标准复杂。没有人系统地使用这些代码，而是依靠询问患者的体重、体重减轻情况、食物摄入量和食欲。肿瘤专家优先识别需要营养治疗的患者，认为诊断代码对于提供高质量的治疗没有必要。提高代码使用率的建议包括经济激励措施、加强与临床营养师的合作以及自动编码的数字系统。他们没有使用 ICD-10 营养不良编码，认为复杂的诊断标准和编码与营养治疗缺乏相关性是限制因素。

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引用次数: 0

Nutritional risk, nutrition impact symptoms, and dietary intake after four or more days of admission: A cross-sectional study on hospitalised patients 入院四天或四天以上后的营养风险、营养影响症状和饮食摄入量：一项针对住院患者的横断面研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-09-28 DOI: 10.1016/j.nutos.2024.09.011

Jonas Anias Svendsen , Ines Raben , Matias Holskou , Anja Weirsøe Dynesen

Background

Regular audits on nutrition screening, therapy, and dietary intake monitoring are essential for ensuring optimal nutrition practice. This study aimed to investigate the prevalence of nutritional risk, nutritional coverage, and nutrition impact symptoms (NIS) in hospitalized patients.

Methods

A cross-sectional study was conducted, including adult patients admitted for ≥5 days on November 1, 2023. Data were collected from medical records to estimate the prevalence of nutritional risk using the NRS-2002 score. Additionally, data on dietary intake and NIS were collected through interviews with patients identified as being at nutritional risk.

Results

A total of 104 patients (48% females) were included in the study, with 51% identified as being at nutritional risk. Patients at nutritional risk and those not at risk differed significantly in terms of length of admission (median 9 (IQR: 7–17) vs. 7 days (6–11), P = 0.015) and BMI (median 22.3 (IQR: 20.3–27.7) vs. 25.9 (22.9–29.7), P = 0.015). Patients at nutritional risk had a median energy coverage of 60% (IQR: 38–87) and a median protein coverage of 45% (IQR: 36–82). However, only 42% of them achieved an energy intake of ≥75% of the estimated requirement, while 28% met the same level for protein intake. The most prevalent NIS affecting dietary intake was ‘diarrhea, constipation, or discomfort from the stomach’, reported by 50% of patients.

Conclusion

This study highlights the significant prevalence of nutritional risk among hospitalised patients, with one in every two patients identified as being at risk. Despite efforts, nutritional needs were not adequately met, particularly regarding protein intake. Regular audits and interdisciplinary collaboration are necessary for improving nutritional care and outcomes in hospital settings.

背景定期审核营养筛查、治疗和膳食摄入监测对于确保最佳营养实践至关重要。本研究旨在调查住院患者的营养风险、营养覆盖率和营养影响症状（NIS）的发生率。方法进行了一项横断面研究，包括 2023 年 11 月 1 日入院时间≥5 天的成年患者。研究人员从病历中收集数据，使用 NRS-2002 评分估算营养风险的发生率。此外，还通过对被确定为有营养风险的患者进行访谈来收集有关饮食摄入和 NIS 的数据。结果共有 104 名患者（48% 为女性）被纳入研究，其中 51% 被确定为有营养风险。营养风险患者与非营养风险患者在入院时间（中位数 9 天（IQR：7-17）对 7 天（6-11），P = 0.015）和体重指数（中位数 22.3（IQR：20.3-27.7）对 25.9（22.9-29.7），P = 0.015）方面存在显著差异。营养风险患者的能量覆盖率中位数为 60%（IQR：38-87），蛋白质覆盖率中位数为 45%（IQR：36-82）。然而，只有 42% 的患者的能量摄入量≥75%，而 28% 的患者的蛋白质摄入量达到了同样的水平。影响饮食摄入的最常见营养不良症状是 "腹泻、便秘或胃部不适"，有 50% 的患者报告了这一症状。尽管做出了努力，但营养需求仍未得到充分满足，尤其是蛋白质摄入方面。定期审核和跨学科合作对于改善医院的营养护理和治疗效果十分必要。

{"title":"Nutritional risk, nutrition impact symptoms, and dietary intake after four or more days of admission: A cross-sectional study on hospitalised patients","authors":"Jonas Anias Svendsen , Ines Raben , Matias Holskou , Anja Weirsøe Dynesen","doi":"10.1016/j.nutos.2024.09.011","DOIUrl":"10.1016/j.nutos.2024.09.011","url":null,"abstract":"<div><h3>Background</h3><div>Regular audits on nutrition screening, therapy, and dietary intake monitoring are essential for ensuring optimal nutrition practice. This study aimed to investigate the prevalence of nutritional risk, nutritional coverage, and nutrition impact symptoms (NIS) in hospitalized patients.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted, including adult patients admitted for ≥5 days on November 1, 2023. Data were collected from medical records to estimate the prevalence of nutritional risk using the NRS-2002 score. Additionally, data on dietary intake and NIS were collected through interviews with patients identified as being at nutritional risk.</div></div><div><h3>Results</h3><div>A total of 104 patients (48% females) were included in the study, with 51% identified as being at nutritional risk. Patients at nutritional risk and those not at risk differed significantly in terms of length of admission (median 9 (IQR: 7–17) vs. 7 days (6–11), <em>P</em> = 0.015) and BMI (median 22.3 (IQR: 20.3–27.7) vs. 25.9 (22.9–29.7), <em>P</em> = 0.015). Patients at nutritional risk had a median energy coverage of 60% (IQR: 38–87) and a median protein coverage of 45% (IQR: 36–82). However, only 42% of them achieved an energy intake of ≥75% of the estimated requirement, while 28% met the same level for protein intake. The most prevalent NIS affecting dietary intake was ‘diarrhea, constipation, or discomfort from the stomach’, reported by 50% of patients.</div></div><div><h3>Conclusion</h3><div>This study highlights the significant prevalence of nutritional risk among hospitalised patients, with one in every two patients identified as being at risk. Despite efforts, nutritional needs were not adequately met, particularly regarding protein intake. Regular audits and interdisciplinary collaboration are necessary for improving nutritional care and outcomes in hospital settings.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 121-130"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taste perception changes in multiple myeloma and head & neck cancer patients: A qualitative study 多发性骨髓瘤和头颈部癌症患者的味觉变化：定性研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2024-09-26 DOI: 10.1016/j.nutos.2024.09.010

Ghias Kulsoom , Maura Dowling , Krawczyk Janusz , Edel Barrett , Gupta Ananya

Changes in taste have been perceived as a common side effect of different cancers and may lead to malnutrition. Hence, the importance of understanding cancer patients' sensory taste perceptions and its impact on nutritional status, quality of life (QoL), and oral nutrition supplements (ONS) compliance becomes crucial. This qualitative study involved semi-structured, in-depth interviews with 24 adults (15 with multiple myeloma and 9 with head & neck cancer). The interviews were transcribed and the data analysis was conducted using reflexive thematic analysis and template analysis. This guided the development of four themes: 1. Taste and smell changes, 2. Impact on nutritional status and quality of life, 3. Information and help available for people experiencing changes in their taste, and 4. ONS and its compliance. Our findings show significant negative impact of chemosensory changes on nutritional status, quality of life and ONS compliance. Patient's experience with the level of support received for the management of taste changes during cancer treatment varied widely. Providing adequate information and support in a timely manner about changes in taste during treatment can improve patients' coping strategies and maintain their nutritional status. Overall, the findings highlight the importance of addressing taste changes and ONS compliance for people with multiple myeloma and head and neck cancer undergoing treatment. Specifically, the taste changes and its impact experienced by people with head and neck cancer were found to be more severe than those experienced by multiple myeloma patients. This study provides an understanding of changes in sensory taste perception experienced by cancer patients and its impact on nutritional status and QoL. This understanding can provide insight into ways to improve ONS consumption and compliance for preventing malnutrition. It is crucial to further conduct ONS sensory evaluations that cater to the specific needs of this cohort to help prevent malnutrition among cancer patients.

味觉变化被认为是不同癌症的常见副作用，可能导致营养不良。因此，了解癌症患者的味觉感受及其对营养状况、生活质量（QoL）和口服营养补充剂（ONS）依从性的影响至关重要。这项定性研究对 24 名成人（15 名多发性骨髓瘤患者和 9 名头部及颈部癌症患者）进行了半结构化深入访谈。对访谈内容进行了誊写，并采用反思性主题分析和模板分析法进行了数据分析。在此基础上形成了四个主题：1.味觉和嗅觉的变化；2.对营养状况和生活质量的影响；3.为味觉发生变化的人提供的信息和帮助；4.ONS 及其合规性。ONS 及其合规性。我们的研究结果表明，化疗感官变化对营养状况、生活质量和服用 ONS 的依从性有很大的负面影响。患者对癌症治疗期间味觉变化管理所获得的支持程度的体验差异很大。及时提供有关治疗期间味觉变化的充足信息和支持，可以改善患者的应对策略，维持他们的营养状况。总之，研究结果突出表明，对于正在接受治疗的多发性骨髓瘤和头颈部癌症患者来说，解决味觉变化和遵从 ONS 的重要性。具体而言，研究发现头颈癌患者的口味变化及其影响比多发性骨髓瘤患者更为严重。这项研究有助于了解癌症患者的味觉变化及其对营养状况和生活质量的影响。这种认识可以帮助人们了解如何改善 ONS 的食用量和依从性，从而预防营养不良。至关重要的是要进一步开展 ONS 感官评估，以满足这一群体的特殊需求，帮助癌症患者预防营养不良。

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引用次数: 0