Clinical Nutrition Open Science最新文献_第4页

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.11.004

Antonella Cotoia, Pierre Singer

引用次数: 0

Association between dietary inflammatory index and serum hs-CRP: A systematic review and meta-analysis 饮食炎症指数与血清hs-CRP的相关性：系统回顾和荟萃分析

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.11.003

Sarah Al-Fayez , Fatmah Othman , Hadeel Al Bedewi , Aiman El-Saed

Aim

Chronic inflammation is a significant risk factor for the development of chronic diseases, including cardiovascular disease and diabetes. Increasing evidence explores the connection between the Dietary Inflammatory Index (DII) and inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP). However, results from individual studies are inconsistent; therefore, this study aims to assess the overall strength of the association between the DII and (hs-CRP) levels.

Methods

A systematic review was conducted following the PRISMA guidelines. Published observational studies investigating the relationship between DII and (hs-CRP) levels were sourced from MEDLINE and Web of Science. The primary outcome was the effectiveness of DII in predicting (hs-CRP) levels.

Results

The review included 19 observational studies with 65,929 participants from diverse populations. Seven studies qualified for meta-analysis. The pooled data demonstrated a significant positive association between DII scores and (hs-CRP) levels, suggesting that individuals with higher DII scores have an increased risk of elevated (hs-CRP), with a pooled OR of 1.42 [95% CI 1.31, 1.54, p < 0.001, I2 = 0%]. Sensitivity analysis verified the stability of these findings.

Conclusion

Observational evidence indicates that DII could serve as a predictor for (hs-CRP) levels. Employing DII to assess the inflammatory potential of diets may assist in managing inflammation-related diseases through dietary modifications. Further research is recommended to identify optimal methods for evaluating DII and its links with health outcomes.

慢性炎症是慢性疾病发展的重要危险因素，包括心血管疾病和糖尿病。越来越多的证据探讨了饮食炎症指数（DII）与炎症生物标志物（如高敏c反应蛋白（hs-CRP））之间的联系。然而，个别研究的结果并不一致；因此，本研究旨在评估DII和（hs-CRP）水平之间关联的总体强度。方法按照PRISMA指南进行系统评价。已发表的调查DII和（hs-CRP）水平之间关系的观察性研究来自MEDLINE和Web of Science。主要结果是DII预测hs-CRP水平的有效性。该综述包括19项观察性研究，来自不同人群的65,929名参与者。7项研究符合荟萃分析的要求。汇总数据显示DII评分与hs-CRP水平之间存在显著正相关，表明DII评分较高的个体hs-CRP升高的风险增加，汇总OR为1.42 [95% CI 1.31, 1.54, p < 0.001, I2 = 0%]。敏感性分析证实了这些结果的稳定性。结论观察性证据提示DII可作为（hs-CRP）水平的预测因子。采用DII来评估饮食的炎症潜力可能有助于通过饮食调整来管理炎症相关疾病。建议进行进一步研究，以确定评估DII及其与健康结果的联系的最佳方法。

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引用次数: 0

Aquatic foods in human health, nutrition, and overall welfare 水产食品对人类健康、营养和整体福利的影响

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.11.005

Koshal Kumar

This paper deals with the role of aquatic foods in human health, nutrition, welfare, etc. Earth is covered with 70% water, and approximately 30% of the human population lacks adequate nutrition. Aquatic foods are essential for improving human global health and nutrition levels. Japan consumes more aquatic plant and animal products than any other nation, reports the lowest rates of obesity and heart disease, and has one of the longest human life spans in the world. According to the FAO, over three billion people consume more than 20% of animal protein per person, and 4.3 billion people consume at least 15%. Aquatic foods play an essential role in the nutrition of humans and provide them with animal protein, vital amino acids, omega-3 fatty acids, vitamins, minerals, trace elements, etc. Aquatic foods from plant and animal sources provide vital nutrients to humans that promote health and prevent disease.

本文论述了水产食品在人类健康、营养、福利等方面的作用。地球被70%的水覆盖，大约30%的人口缺乏足够的营养。水生食品对改善全球人类健康和营养水平至关重要。日本消费的水生动植物产品比其他任何国家都多，肥胖和心脏病发病率最低，也是世界上人类寿命最长的国家之一。根据联合国粮农组织的数据，超过30亿人消耗了超过20%的动物蛋白，43亿人消耗了至少15%的动物蛋白。水产食品在人类的营养中起着至关重要的作用，为人类提供动物蛋白、重要氨基酸、omega-3脂肪酸、维生素、矿物质、微量元素等。来自植物和动物的水生食物为人类提供重要的营养，促进健康和预防疾病。

引用次数: 0

Corrigendum to “The association between dietary fat intake and benign breast diseases: a systematic review” [Clin Nutr Open Sci 62 (2025) 102–113] “膳食脂肪摄入与良性乳腺疾病之间的关系：系统综述”的勘误表[临床营养学开放科学62 (2025)102-113]

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.09.003

Amir Hossein Faghfouri , Fatemeh Azizi-Soleiman , Sevda Saleh-Ghadimi , Hamed Jafari-Vayghan

引用次数: 0

A network meta-analysis of the clinical efficacy of different dietary patterns in the treatment of adult metabolic dysfunction-associated steatotic liver diseases 不同饮食模式治疗成人代谢功能障碍相关脂肪变性肝病临床疗效的网络meta分析

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.11.006

Diwen Yu , Peipei Yu , Wanting Huang , Pengwei Zhang , Li Li

Background

Deipite considerable literature supports the benefits of dietary interventions for Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), the most effective dietary approach remains unclear. We conducted a systematic review and network meta-analysis (NMA) to assess the relative efficacy of different dietary approaches on improving liver function, Controlled Attenuation Parameter (CAP), body weight and Body Mass Index (BMI) in adults with MASLD.

Methods

We searched PubMed, the Cochrane Library, Embase and Web of Science up to March 2025 for controlled trials of different dietary approaches in adult MASLD patients. Primary outcomes were liver function and CAP, with secondary outcomes being body weight and BMI. For each outcome, the pooled effect of each intervention compared with others was determined. Mean differences (MDs) and 95% confidence intervals (95%CI) were calculated. The surface under the cumulative ranking curve (SUCRA) was used to rank dietary approaches.

Results

Overall, 30 trials were included, comparing five macronutrient approaches (Moderate macronutrients, Low carbohydrate (LCD), Low fat, Dietary advice, and Usual diet) and 12 dietary interventions [Atkins, DASH, Weight Watchers, Volumetrics, Low sugar diet, Low GI diet (LGID), Calorie Restriction (CR), Portfolio, Mediterranean, Low fat diet (LFD), Dietary advice, and Usual diet], involving 2051 patients. Regarding macronutrients, Moderate macronutrients demonstrated the most effective improvement in liver function (SUCRA: 76.35%); LCD proved most effective for improving both CAP (SUCRA: 91.5%) and body weight (SUCRA: 94.35%). Among dietary patterns, Portfolio was most effective for improving liver function (SUCRA: 85%), while LGID was most effective for improving CAP (SUCRA: 74.9%); The Atkins diet demonstrated the best overall improvement in body mass and BMI (SUCRA: 76.55%).

Conclusions

Moderate macronutrients and Portfolio diets were most effective for improving liver function, while LGID was the most effective approach for reducing CAP. The LCD and Atkins diets were considered the most effective dietary approaches for comprehensively improving body mass and BMI.

尽管大量文献支持饮食干预对代谢功能障碍相关脂肪变性肝病（MASLD）的益处，但最有效的饮食方法仍不清楚。我们进行了一项系统综述和网络荟萃分析（NMA），以评估不同饮食方式对改善成年MASLD患者肝功能、控制衰减参数（CAP）、体重和体重指数（BMI）的相对功效。方法：我们检索PubMed、Cochrane图书馆、Embase和Web of Science，检索截至2025年3月的成人MASLD患者不同饮食方法的对照试验。主要结局是肝功能和CAP，次要结局是体重和BMI。对于每个结果，确定了每个干预措施与其他干预措施的综合效果。计算平均差值（MDs）和95%置信区间（95% ci）。采用累积排序曲线下曲面（SUCRA）对饲粮方式进行排序。结果共纳入30项试验，比较了5种宏量营养素方法（中度宏量营养素、低碳水化合物（LCD）、低脂肪、饮食建议和常规饮食）和12种饮食干预方法（Atkins、DASH、Weight Watchers、Volumetrics、低糖饮食、低GI饮食（LGID）、热量限制（CR）、组合饮食、地中海饮食、低脂肪饮食（LFD）、饮食建议和常规饮食），共2051例患者。在宏量营养素方面，适量宏量营养素对肝功能的改善效果最好（supra: 76.35%）；LCD被证明是最有效的改善CAP （SUCRA: 91.5%）和体重（SUCRA: 94.35%）。在膳食模式中，Portfolio对改善肝功能最有效（SUCRA: 85%）， LGID对改善CAP最有效（SUCRA: 74.9%）；阿特金斯饮食法对体重和BMI的总体改善效果最好（supra: 76.55%）。结论适量宏量营养素和组合饮食对改善肝功能最有效，LGID是降低CAP最有效的饮食方式，LCD和Atkins饮食是综合改善体重和BMI最有效的饮食方式。

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引用次数: 0

The role of nutritional assessment and intervention in lung cancer radiotherapy: Current status and advances 营养评估与干预在肺癌放疗中的作用：现状与进展

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-12-01 DOI: 10.1016/j.nutos.2025.11.012

Yangyang Gong, Yushu Han, Yiyin Liang, Weiwei Zhang, Zhen Jia, Liying Yang, Huojun Zhang

Lung cancer is the leading cause of cancer-related deaths worldwide, and malnutrition during its treatment significantly impacts therapeutic outcomes and patients' quality of life. Radiotherapy, as one of the primary treatment modalities for lung cancer, often leads to a range of side effects such as nausea, esophagitis, and taste alterations, which can result in inadequate nutrient intake and sarcopenia. These conditions exacerbate treatment toxicity and increase the risk of poor prognosis. This article systematically reviews the methods of nutritional assessment, intervention strategies, and their effects on treatment toxicity and survival outcomes in lung cancer patients undergoing radiotherapy. By synthesizing existing evidence, this systematic review aims to provide a theoretical foundation for optimizing nutritional management in clinical practice, thereby improving survival outcomes and quality of life for lung cancer patients.

肺癌是全球癌症相关死亡的主要原因，治疗期间的营养不良显著影响治疗结果和患者的生活质量。放疗作为肺癌的主要治疗方式之一，往往会导致一系列副作用，如恶心、食管炎和味觉改变，这可能导致营养摄入不足和肌肉减少症。这些情况加剧了治疗毒性并增加了预后不良的风险。本文系统综述了肺癌放疗患者的营养评估方法、干预策略及其对治疗毒性和生存结果的影响。本系统综述旨在通过综合现有证据，为临床实践中优化营养管理提供理论依据，从而改善肺癌患者的生存结局和生活质量。

引用次数: 0

The potensial effects of high protein diet on renal function in body builders in Erbil city 埃尔比勒市健身者高蛋白饮食对肾功能的潜在影响

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-11-13 DOI: 10.1016/j.nutos.2025.11.001

Muhanad Salah Mawlood

Background

The Kidneys are known for their critical role in waste filtration and urine production, an important role of the kidney in the protein metabolism including breakdown and excretion of protein, excessive protein intake can impose significant stress on the kidneys, potentially leading to various complications.

Aim

aim of this study is to identify any possible health risks associated with consuming high protein diet.

Persons and methods

This study was cross – sectional study comprised (40) healthy participants between the ages of 18 and 48 participated. The participants were classified by two types of classification: according to protein intake per day and by duration of protein intake. (10) people were assigned to the control group, (18) athletes who consumed less than 200 grams of protein per day were assigned to the low-protein diet group, and (12) athletes who consumed more than 200 grams of protein per day were assigned to the high-protein diet group. According to duration of protein intake participants were divided into three groups: seventeen (17) participants less than five years, seven (7) participants between five to ten, and (6) participants more than 10 years of duration.

Result

It is clearly demonstrated statistically significant differences in mean of age (p = 0.003), blood urea (p = 0.007), serum creatinine (p < 0.001), Urinary Albumin to Creatinine Ratio (p < 0.001) and Urinary Protein to Creatinine Ratio (p < 0.001) between the control group and the entire athletic (<200 g/day and ≥200 g/day) groups. A highly significant differences between the means of Urinary Albumin to Creatinine Ratio (ACR) and Urinary Protein to Creatinine Ratio (PCR) between the three duration of protein intake (<5, 5–10 and > 10 years) groups (p < 0.001).

Conclusion

The findings of this study highlight the importance of moderation in protein intake to maintain optimal renal health. While protein is a vital nutrient, excessive and prolong consumption, particularly in the context of a high-protein diet, may pose risks to kidney function.

肾脏在废物过滤和尿液产生中起着关键作用，肾脏在蛋白质代谢中起着重要作用，包括蛋白质的分解和排泄，过量的蛋白质摄入会给肾脏带来巨大的压力，可能导致各种并发症。本研究的目的是确定与食用高蛋白饮食有关的任何可能的健康风险。对象与方法本研究为横断面研究，由40名年龄在18 ~ 48岁的健康受试者组成。参与者被分为两类：根据每天的蛋白质摄入量和蛋白质摄入的持续时间。（10）人被分配到对照组，（18）每天摄入少于200克蛋白质的运动员被分配到低蛋白饮食组，（12）每天摄入超过200克蛋白质的运动员被分配到高蛋白饮食组。根据蛋白质摄入的持续时间，参与者被分为三组：17（17）名参与者少于5年，7(7)名参与者在5到10年之间，6(6)名参与者超过10年。结果对照组与全运动组（200 g/d和≥200 g/d）在平均年龄（p = 0.003）、血尿素（p = 0.007）、血清肌酐（p < 0.001）、尿白蛋白/肌酐比（p < 0.001）、尿蛋白/肌酐比（p < 0.001）上有明显的统计学差异。尿白蛋白/肌酐比（ACR）和尿蛋白/肌酐比（PCR）在三个蛋白质摄入持续时间（5年、5年至10年）组之间存在高度显著差异（p < 0.001）。结论本研究结果强调了适度摄入蛋白质对维持肾脏健康的重要性。虽然蛋白质是一种重要的营养物质，但过量和长时间摄入蛋白质，特别是在高蛋白饮食的背景下，可能会对肾功能构成风险。

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引用次数: 0

Determination of oxalate content in commercial cranberry supplements 商品蔓越莓补充剂中草酸盐含量的测定

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-11-07 DOI: 10.1016/j.nutos.2025.10.014

Christina A. Ackerman, Madison B. Brock, Paulina Rivera, Matthew J. Fhaner, Jessica L. Kelts

Kidney stones are a common ailment that is painful to individuals and costly to the US healthcare system. The vast majority of those kidney stones are composed of calcium oxalate, with or without calcium phosphate. Individuals prone to kidney stones follow dietary guidelines to reduce the chance of recurrence. These guidelines focus on lowering the amount of calcium and/or oxalate in the urine to prevent formation of new stones. Many vegetables and some fruits have sizable oxalate content and could contribute to stone formation. It is also known that supplementation with vitamin C is associated with higher oxalate excretion as oxalate is a metabolite of vitamin C metabolism. However, oxalate content of other types of supplements has not been quantified. In this study, we examine several cranberry supplements for their soluble oxalate content. Cranberry supplements are often recommended to patients with recurrent urinary tract infections and/or overactive bladder and are touted by advertisers as supportive of urinary tract health. The level of oxalate found in these supplements was low enough that their consumption would not be contraindicated for most kidney stone patients.

肾结石是一种常见的疾病，对个人来说是痛苦的，对美国的医疗体系来说也是昂贵的。绝大多数肾结石是由草酸钙组成的，有或没有磷酸钙。易患肾结石的人遵循饮食指南以减少复发的机会。这些指南侧重于降低尿液中钙和/或草酸盐的含量，以防止新结石的形成。许多蔬菜和一些水果含有相当多的草酸，可能有助于结石的形成。众所周知，补充维生素C与较高的草酸排泄有关，因为草酸是维生素C代谢的代谢物。然而，其他类型补充剂的草酸盐含量尚未量化。在这项研究中，我们检查了几种蔓越莓补充剂的可溶性草酸含量。蔓越莓补充剂经常被推荐给复发性尿路感染和/或膀胱过度活跃的患者，并被广告商吹捧为支持尿路健康。在这些补充剂中发现的草酸盐含量足够低，因此大多数肾结石患者不会忌食这些补充剂。

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引用次数: 0

Educational impact of a tablet application on nutrition in maintenance hemodialysis patients: A clinical pilot study 片剂应用对维持性血液透析患者营养的教育影响：一项临床试点研究

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-11-05 DOI: 10.1016/j.nutos.2025.10.015

Rolf Pachlatko , Patrice M. Ambühl , Andreas Schleich

Objective

To evaluate whether a novel, image-based quiz application used during dialysis sessions can improve electrolyte control and fluid balance in hemodialysis patients by enhancing dietary knowledge.

Methods

In this single-center, non-randomized, open-label study, 49 maintenance hemodialysis patients of our dialysis center in Zurich (Switzerland) used a tablet-based quiz application during dialysis sessions over a four-week period. Dialysis was performed three times a week with a mean duration of 230 min. The app presented visual comparisons of food items regarding sodium, potassium, and phosphate content. Primary outcomes were changes in serum potassium and phosphate; ultrafiltration volume was a secondary outcome. Learning activity was assessed based on the number and accuracy of answers. All laboratory values were collected at the beginning of the week (Monday or Tuesday) after the long interval before dialysis began. The laboratory analyses were done in the hospital laboratory.

Results

No statistically significant changes were observed in serum potassium (−0.038 mmol/L, P=0.542), phosphate (+0.083 mmol/L, P=0.115), or ultrafiltration volume (+67 mL, P=0.128). However, an increase in the proportion of correct answers (from 67.2% to 73.5%) indicated improved dietary knowledge.

Conclusion

Although the digital intervention led to detectable effects in training intensity and knowledge, it did not translate into improvements in electrolyte levels or fluid balance. Patient motivation and engagement intensity may influence outcomes.

Clinical trial registration number

NCT05111184 (Clinicaltrials.gov).

目的评价一种新型的基于图像的血液透析测试应用程序是否可以通过提高饮食知识来改善血液透析患者的电解质控制和体液平衡。方法在这项单中心、非随机、开放标签的研究中，来自苏黎世（瑞士）透析中心的49名维持性血液透析患者在透析期间使用了一种基于片剂的测试应用程序，为期四周。透析每周进行3次，平均持续时间为230分钟。这款应用展示了食物中钠、钾和磷酸盐含量的视觉对比。主要结局是血清钾和磷酸盐的变化；超滤体积是次要指标。学习活动根据答案的数量和准确性进行评估。在透析开始前的长时间间隔后，在一周的开始（星期一或星期二）收集所有的实验室值。实验室分析在医院实验室完成。结果两组血清钾（- 0.038 mmol/L， P=0.542）、磷酸（+0.083 mmol/L， P=0.115）、超滤体积（+67 mL， P=0.128）变化均无统计学意义。然而，正确答案比例的增加（从67.2%增加到73.5%）表明饮食知识有所提高。结论虽然数字干预在训练强度和知识方面产生了明显的影响，但它并没有转化为电解质水平或体液平衡的改善。患者的动机和参与强度可能影响结果。临床试验注册号bernct05111184 （Clinicaltrials.gov）。

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引用次数: 0

Effectiveness of omega-3 supplementation in reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults 补充omega-3对降低成人与代谢功能障碍相关的脂肪变性肝病程度的有效性

Q3 Nursing

Clinical Nutrition Open Science

Pub Date : 2025-11-05 DOI: 10.1016/j.nutos.2025.10.011

María Dolores Mondéjar Barrios , Karem Justhin Rodas Trujillo , Juana Olga Espíritu Aguirre , Matilde Anais Matos Inga , Sandra Lisseth Mori Díaz , Luis Alberto Cabanillas Chirinos

Background

Steatotic liver disease associated with metabolic dysfunction is the most common liver disease worldwide . Currently, there are no specific medications for its treatment, so it is necessary to seek options that contribute to slowing its progression and reversing it in its early stages . The objective The objective of this study was to determine the effectiveness of omega-3 supplementation in reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults.

Methods

A quasi-experimental study with 40 participants aged 25 years and older was conducted from August 2024 to April 2025, in Trujillo, Peru. Data were collected through an interview and medical evaluation. An abdominal ultrasound was performed to confirm the diagnosis of liver disease, as well as blood transaminase tests, among others. Descriptive and inferential statistics were applied in the statistical analysis. The experimental group received omega-3 supplementation for two months; the control group was recommended a low-carbohydrate and low-fat diet. Both groups were evaluated with abdominal ultrasound at the third month.

Results

The relevant anthropometric parameters were abdominal obesity (95%) and overweight (55%). Statistical significance was found after supplementation (p = 0.005 < 0.05).

Conclusions

Omega-3 supplementation at a dose of 1000 mg every 12 hours for 2 months was effective in significantly reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults, showing that it is possible to obtain a favorable effect in the short term and with a lower probability of adverse effects.

背景与代谢功能障碍相关的脂肪变性肝病是世界范围内最常见的肝病。目前，还没有特定的治疗药物，因此有必要寻求有助于减缓其进展并在早期阶段逆转其发展的选择。目的本研究的目的是确定omega-3补充剂在降低成人与代谢功能障碍相关的脂肪变性肝病程度方面的有效性。方法于2024年8月至2025年4月在秘鲁特鲁希略市对40名年龄在25岁及以上的参与者进行准实验研究。通过访谈和医疗评估收集数据。进行了腹部超声检查以确认肝病的诊断，并进行了血液转氨酶检查等。统计分析采用描述统计和推理统计。实验组服用omega-3补充剂两个月；对照组被推荐低碳水化合物和低脂肪的饮食。两组均于术后第3个月行腹部超声检查。结果相关的人体测量参数为腹部肥胖（95%）和超重（55%）。补充后差异有统计学意义（p = 0.005 < 0.05）。结论以每12小时1000 mg的剂量补充somega -3，持续2个月，可显著降低成人伴代谢功能障碍的脂肪变性肝病程度，短期内可获得良好效果，不良反应发生概率较低。

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引用次数: 0