Yohanes Dimas Pamungkas Priyambodo, Diar Mia Ardani, R. F. Perdana
Objective: To describe laryngeal abnormalities undergoing microlaryngeal surgery (MLS). Material and Methods: A retrospective analytical study by examining the central medical record and electronic medical record of patients with laryngeal disorders in the otorhinolaryngology head and neck surgery (ORL-HNS) Outpatient Unit and the Teratai ORL-HNS Surgery Inpatient Care Unit at Dr. Soetomo General Hospital, Surabaya, from January 1 until December 31, 2019, utilizing the chi-square test followed by the Wald test. Results: The number of patient visits from January 1 until December 31, 2019, amounted to 80 patients, most of whom were male and belonged to the 19-60 age group. The histopathology results of patients with neoplasms indicated moderately differentiated squamous cell carcinoma, while the same procedure applied to patients without neoplasms mainly indicated vocal nodules. In this case, the most used technique was a biopsy. Patients with smoking risk factors amounted to 38, while those without smoking risk factors amounted to 42. Conclusion: MLS is used as a means of diagnosis and therapy, including cases of benign and malignant neoplasms.
{"title":"Patients with Laryngeal Disorders Who Undergone Microlaryngeal Surgery at The Dr. Soetomo General Hospital Surabaya","authors":"Yohanes Dimas Pamungkas Priyambodo, Diar Mia Ardani, R. F. Perdana","doi":"10.31584/jhsmr.2023939","DOIUrl":"https://doi.org/10.31584/jhsmr.2023939","url":null,"abstract":"Objective: To describe laryngeal abnormalities undergoing microlaryngeal surgery (MLS). Material and Methods: A retrospective analytical study by examining the central medical record and electronic medical record of patients with laryngeal disorders in the otorhinolaryngology head and neck surgery (ORL-HNS) Outpatient Unit and the Teratai ORL-HNS Surgery Inpatient Care Unit at Dr. Soetomo General Hospital, Surabaya, from January 1 until December 31, 2019, utilizing the chi-square test followed by the Wald test. Results: The number of patient visits from January 1 until December 31, 2019, amounted to 80 patients, most of whom were male and belonged to the 19-60 age group. The histopathology results of patients with neoplasms indicated moderately differentiated squamous cell carcinoma, while the same procedure applied to patients without neoplasms mainly indicated vocal nodules. In this case, the most used technique was a biopsy. Patients with smoking risk factors amounted to 38, while those without smoking risk factors amounted to 42. Conclusion: MLS is used as a means of diagnosis and therapy, including cases of benign and malignant neoplasms. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47045059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To ascertain any relationship between coping strategies, sexual orientation and gender diversity in regard to high school students in Bangkok, and to examine coping strategies among sexual and gender minority youths. Material and Methods: This cross-sectional survey included 600 students across Bangkok, Thailand. Participants completed an online questionnaire, consisting of demographic data and the Adolescent Coping Scale (Thai version). Descriptive statistics, the Mann-Whitney U test, and the Kruskal-Wallis test were used for data analysis (p-value≤0.05). Results: The participants included 301 males (50.2%), and 299 females (49.8%), with a mean age of 16.6. The sample identified as 83.7% cisgender, 16.3% non-cisgender (transgender, non-conforming, questioning/unspecified, and others), 64.8% heterosexual, and 35.2% non-heterosexual (homosexual, bisexual, asexual, pansexual, questioning/unspecified, and others). Females used more non-productive coping strategies than males (p-value=0.001), non-cisgender youths used more non-productive coping than cisgender youths (p-value<0.001), and non-heterosexual youths used more non-productive coping than heterosexual youth (p-value<0.001). Coping strategies mostly used by sexual and gender minority male youths were worrying, ignoring the problem, and wishful thinking, while coping strategies most used by sexual and gender minority female youths were worrying, not coping, and keeping to one’s self. Conclusion: Differences in regards to the sex assigned at birth, gender identity, and sexual orientation had a statistically significant correlation with different coping strategies, specifically in sexual and gender minority youths who used nonproductive coping strategies.
{"title":"Disparities in Stress Coping Strategies among High School Students, in Bangkok, with Various Sexual Orientations and Gender Identities","authors":"Nikhanif Radenahmad, Tikumporn Hosiri, Tidarat Puranachaikere, Kanthip Thongchoi, Prapim Engkananuvat","doi":"10.31584/jhsmr.2023938","DOIUrl":"https://doi.org/10.31584/jhsmr.2023938","url":null,"abstract":"Objective: To ascertain any relationship between coping strategies, sexual orientation and gender diversity in regard to high school students in Bangkok, and to examine coping strategies among sexual and gender minority youths. Material and Methods: This cross-sectional survey included 600 students across Bangkok, Thailand. Participants completed an online questionnaire, consisting of demographic data and the Adolescent Coping Scale (Thai version). Descriptive statistics, the Mann-Whitney U test, and the Kruskal-Wallis test were used for data analysis (p-value≤0.05). Results: The participants included 301 males (50.2%), and 299 females (49.8%), with a mean age of 16.6. The sample identified as 83.7% cisgender, 16.3% non-cisgender (transgender, non-conforming, questioning/unspecified, and others), 64.8% heterosexual, and 35.2% non-heterosexual (homosexual, bisexual, asexual, pansexual, questioning/unspecified, and others). Females used more non-productive coping strategies than males (p-value=0.001), non-cisgender youths used more non-productive coping than cisgender youths (p-value<0.001), and non-heterosexual youths used more non-productive coping than heterosexual youth (p-value<0.001). Coping strategies mostly used by sexual and gender minority male youths were worrying, ignoring the problem, and wishful thinking, while coping strategies most used by sexual and gender minority female youths were worrying, not coping, and keeping to one’s self. Conclusion: Differences in regards to the sex assigned at birth, gender identity, and sexual orientation had a statistically significant correlation with different coping strategies, specifically in sexual and gender minority youths who used nonproductive coping strategies. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42605780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Triradchayakorn Kaewpunya, N. Howteerakul, S. Siri, N. Suwannapong, Pokket Sirisreetreerux
Objective: This study aimed to assess the prevalence of poor quality of sleep, and its associating factors among Thai elderly with urinary incontinence (UI), in Chiang Rai province. Material and Methods: Study samples from 419 individuals with UI, aged ≥60 years and living in Chiang Rai province were taken. Multi-stage random sampling was used to recruit study participants. Thai versions of the International Consultation on Incontinence Questionnaire-Short Form (TICIQ-UI SF) and the Pittsburg Sleep Quality Index (TPSQI) were used as data collection instruments. Results: Overall, 84.2% of participants had poor quality of sleep (TPSQI >5); with the mean TPSQI score being 8.4±3.16. Approximately 21.5%, 69.2%, and 9.3% had severe, moderate, and mild UI, respectively. Multiple logistic regression analysis revealed that being female (OR=2.77; 95% confidence interval (CI), 1.47-5.24); having a moderate severity of UI (OR=3.63; 95% CI, 1.10-11.96); being a current smoker (OR=6.84; 95% CI, 2.09-22.33); monthly income of <5,000 Baht (<167 USD) (OR=4.27; 95% CI, 1.33-13.73); being a current alcohol consumer (OR=3.04; 95% CI, 1.47-6.28) and being depressed (OR=3.91; 95% CI, 1.44-10.56) were significantly associated with poor quality of sleep. Conclusion: The prevalence of poor quality of sleep among the elderly with UI was rather high. The combined effects of several risk factors caused the elderly with moderate UI to have a poor quality of sleep. Healthcare personnel should regularly conduct screening for quality of sleep, UI, and depression and provide sleep health education to the elderly with UI, especially the elderly with depression, smokers, and alcohol consumers.
{"title":"Quality of Sleep and Associating Factors among the Elderly with Urinary Incontinence","authors":"Triradchayakorn Kaewpunya, N. Howteerakul, S. Siri, N. Suwannapong, Pokket Sirisreetreerux","doi":"10.31584/jhsmr.2023937","DOIUrl":"https://doi.org/10.31584/jhsmr.2023937","url":null,"abstract":"Objective: This study aimed to assess the prevalence of poor quality of sleep, and its associating factors among Thai elderly with urinary incontinence (UI), in Chiang Rai province. Material and Methods: Study samples from 419 individuals with UI, aged ≥60 years and living in Chiang Rai province were taken. Multi-stage random sampling was used to recruit study participants. Thai versions of the International Consultation on Incontinence Questionnaire-Short Form (TICIQ-UI SF) and the Pittsburg Sleep Quality Index (TPSQI) were used as data collection instruments. Results: Overall, 84.2% of participants had poor quality of sleep (TPSQI >5); with the mean TPSQI score being 8.4±3.16. Approximately 21.5%, 69.2%, and 9.3% had severe, moderate, and mild UI, respectively. Multiple logistic regression analysis revealed that being female (OR=2.77; 95% confidence interval (CI), 1.47-5.24); having a moderate severity of UI (OR=3.63; 95% CI, 1.10-11.96); being a current smoker (OR=6.84; 95% CI, 2.09-22.33); monthly income of <5,000 Baht (<167 USD) (OR=4.27; 95% CI, 1.33-13.73); being a current alcohol consumer (OR=3.04; 95% CI, 1.47-6.28) and being depressed (OR=3.91; 95% CI, 1.44-10.56) were significantly associated with poor quality of sleep. Conclusion: The prevalence of poor quality of sleep among the elderly with UI was rather high. The combined effects of several risk factors caused the elderly with moderate UI to have a poor quality of sleep. Healthcare personnel should regularly conduct screening for quality of sleep, UI, and depression and provide sleep health education to the elderly with UI, especially the elderly with depression, smokers, and alcohol consumers. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43677772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Diabetes mellitus is a metabolic disorder that develops over time and affects the cardiovascular system, eyes, kidneys, nerves, and blood sugar levels. The aim of this investigation was to determine the prevalence of diabetic mellitus patients, identify the associating risk factors using a multilevel longitudinal model, and understand the multilevel model changes for the level-1 and level-2 models. Material and Methods: We examined such types of scenarios using multilevel longitudinal models such as the simple random intercept multilevel model, the random coefficient model, and the null model. Results: There were 248 individuals with diabetes mellitus enrolled in the study for follow-up measurements over 4 time points, among these 248 individuals, 211 had complete data for all four time points. Based on the intraclass correlation coefficient, much of the variability (88.35%) in diabetes mellitus patients was accounted for by the follow-up time in this study, whereas 11.65% of the variability could not be accounted for by the follow-up time. Moreover, the data analysis suggested that sex had a significant effect on diabetes mellitus patients with the progression of time. Conclusion: Based on the results of our study, sex, baseline fasting and educational status had a significant effect on diabetes mellitus patients over time. The educational status of diabetes mellitus patients was found to have a significant effect throughout the follow-up time; this shows that when treating diabetes mellitus patients, the physician should beware of the nature of the disease and how to management diabetes requires a high level of awareness and motivation on part of the patients regarding self-care.
{"title":"Application of Longitudinal Data the Multilevel Models Approach on Diabetes Mellitus","authors":"W. Moges, Tenaw Endalamaw","doi":"10.31584/jhsmr.2023936","DOIUrl":"https://doi.org/10.31584/jhsmr.2023936","url":null,"abstract":"Objective: Diabetes mellitus is a metabolic disorder that develops over time and affects the cardiovascular system, eyes, kidneys, nerves, and blood sugar levels. The aim of this investigation was to determine the prevalence of diabetic mellitus patients, identify the associating risk factors using a multilevel longitudinal model, and understand the multilevel model changes for the level-1 and level-2 models. Material and Methods: We examined such types of scenarios using multilevel longitudinal models such as the simple random intercept multilevel model, the random coefficient model, and the null model. Results: There were 248 individuals with diabetes mellitus enrolled in the study for follow-up measurements over 4 time points, among these 248 individuals, 211 had complete data for all four time points. Based on the intraclass correlation coefficient, much of the variability (88.35%) in diabetes mellitus patients was accounted for by the follow-up time in this study, whereas 11.65% of the variability could not be accounted for by the follow-up time. Moreover, the data analysis suggested that sex had a significant effect on diabetes mellitus patients with the progression of time. Conclusion: Based on the results of our study, sex, baseline fasting and educational status had a significant effect on diabetes mellitus patients over time. The educational status of diabetes mellitus patients was found to have a significant effect throughout the follow-up time; this shows that when treating diabetes mellitus patients, the physician should beware of the nature of the disease and how to management diabetes requires a high level of awareness and motivation on part of the patients regarding self-care.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43405373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nalinee Kovitwanawong, Napipada Tangcharoenwathanakul, M. Oofuvong, Maliwan Oearsakul, Nichanun Pichayanukul
Objective: We aimed to determine the plasma concentration 50 (CP50) of propofol target controlled infusion (TCI) for successful insertion of four types of supraglottic airway devices (SGD). Material and Methods: This prospective parallel randomized controlled, double blinded, superiority trial was conducted in June 2012 following approval by the Ethics Committee of the Faculty of Medicine, Prince of Songkla University, Thailand. Effect-site concentrations (Ce) of propofol TCI were determined by the modified Dixon’s up-and-down method. After equilibration was established between the plasma and effect-site concentrations, a SupremeTM, ProSealTM(control groups), I-gelTM or Laryngeal Tube Suction IITM devices were inserted. The CP50 was determined by dose response logistic curves presented as means and 95% confidence intervals (CI). The General Estimating Equation was used to determine factors associated with hemodynamic changes. Results: The Ces of TCI propofol requirements in the SupremeTM, ProSealTM, I-gelTM and Laryngeal Tube Suction IITM groups were 5.8, 4.8, 5.6, and 5.8 μg/ml, respectively (effect size [95% CI]: 0.22 [0.06, 0.51], p-value 0.036). The CP50 [95% CIs] in the SupremeTM, ProSealTM, I-gelTM and Laryngeal Tube Suction IITM groups were 5.8 [-0.01, 11.6], 4.9 [3.3, 6.5], 5.7 [5.0, 6.3] and 5.5 [4.7, 6.4] μg/ml, respectively. Heart rates and systolic blood pressure were significantly higher in the Laryngeal Tube Suction IITM group than in the ProSealTM (p-value<0.01) and I-gelTMgroups (p-value<0.01 Conclusion: The ProSealTM and I-gelTM are preferred over the SupremeTM and Laryngeal Tube Suction IITM devices due to the lower CP50 and hemodynamic changes.
{"title":"Dose Response Curves of Plasma Concentration 50 of Propofol Target-Controlled Infusion for Supraglottic Airway Devices: A Randomized Controlled Trial","authors":"Nalinee Kovitwanawong, Napipada Tangcharoenwathanakul, M. Oofuvong, Maliwan Oearsakul, Nichanun Pichayanukul","doi":"10.31584/jhsmr.2023935","DOIUrl":"https://doi.org/10.31584/jhsmr.2023935","url":null,"abstract":"Objective: We aimed to determine the plasma concentration 50 (CP50) of propofol target controlled infusion (TCI) for successful insertion of four types of supraglottic airway devices (SGD). Material and Methods: This prospective parallel randomized controlled, double blinded, superiority trial was conducted in June 2012 following approval by the Ethics Committee of the Faculty of Medicine, Prince of Songkla University, Thailand. Effect-site concentrations (Ce) of propofol TCI were determined by the modified Dixon’s up-and-down method. After equilibration was established between the plasma and effect-site concentrations, a SupremeTM, ProSealTM(control groups), I-gelTM or Laryngeal Tube Suction IITM devices were inserted. The CP50 was determined by dose response logistic curves presented as means and 95% confidence intervals (CI). The General Estimating Equation was used to determine factors associated with hemodynamic changes. Results: The Ces of TCI propofol requirements in the SupremeTM, ProSealTM, I-gelTM and Laryngeal Tube Suction IITM groups were 5.8, 4.8, 5.6, and 5.8 μg/ml, respectively (effect size [95% CI]: 0.22 [0.06, 0.51], p-value 0.036). The CP50 [95% CIs] in the SupremeTM, ProSealTM, I-gelTM and Laryngeal Tube Suction IITM groups were 5.8 [-0.01, 11.6], 4.9 [3.3, 6.5], 5.7 [5.0, 6.3] and 5.5 [4.7, 6.4] μg/ml, respectively. Heart rates and systolic blood pressure were significantly higher in the Laryngeal Tube Suction IITM group than in the ProSealTM (p-value<0.01) and I-gelTMgroups (p-value<0.01 Conclusion: The ProSealTM and I-gelTM are preferred over the SupremeTM and Laryngeal Tube Suction IITM devices due to the lower CP50 and hemodynamic changes. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45198918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Mitsungnern, Saowaluck Inchanta, K. Kongbunkiat, S. Imoun, P. Kotruchin
Objective: The characteristics and risk factors of stroke differ between men and women. Women have a lower mortality but a higher disability rate after a stroke, as well as a higher rate of response to intravenous recombinant tissue plasminogen activator (rt-PA). However, the data regarding gender and outcomes after rt-PA in Asian populations is limited. Hence, this study aimed to make a comparison between men and women regarding mortality and symptomatic intracerebral hemorrhage (S-ICH) after rt-PA. Material and Methods: This was a retrospective cohort study conducted in a specialized stroke unit at a 1000-bed university hospital in Thailand. Adult patients, who were eligible for rt-PA, were recruited from the Stroke Fast Track Registry between 2015-2019. The clinical data and radiological results were collected and analyzed. Results: There was a total of 278 patients,138 of whom were men (49.6%). The men had a lower average age (63 vs. 68 years, p-value<0.001), had higher creatinine levels and higher diastolic blood pressure than the women (1.22±0.93 vs. 0.97±0.84 mg/dl, and 90±15 vs. 86±18 mmHg, all p-values<0.001). The mortality and S-ICH rates were comparable (2.3% vs. 5%, and 8.0% vs. 11.4%, respectively, all p-values>0.05). Having had a history of anti-platelet therapy was a strong risk factor for S-ICH in men (OR 6.43, 95% CI 1.39–29.69); whereas, age was significantly associated with mortality in women (OR 1.13, 95% CI 1.03–1.24). Conclusion: Men and women had similar rates of mortality and S-ICH after rt-PA.
{"title":"The Impact of Gender on Mortality and Symptomatic Intracerebral Hemorrhage in Acute Ischemic Stroke Patients After Intravenous Recombinant Tissue Plasminogen Activator (rt-PA)","authors":"T. Mitsungnern, Saowaluck Inchanta, K. Kongbunkiat, S. Imoun, P. Kotruchin","doi":"10.31584/jhsmr.2023934","DOIUrl":"https://doi.org/10.31584/jhsmr.2023934","url":null,"abstract":"Objective: The characteristics and risk factors of stroke differ between men and women. Women have a lower mortality but a higher disability rate after a stroke, as well as a higher rate of response to intravenous recombinant tissue plasminogen activator (rt-PA). However, the data regarding gender and outcomes after rt-PA in Asian populations is limited. Hence, this study aimed to make a comparison between men and women regarding mortality and symptomatic intracerebral hemorrhage (S-ICH) after rt-PA. Material and Methods: This was a retrospective cohort study conducted in a specialized stroke unit at a 1000-bed university hospital in Thailand. Adult patients, who were eligible for rt-PA, were recruited from the Stroke Fast Track Registry between 2015-2019. The clinical data and radiological results were collected and analyzed. Results: There was a total of 278 patients,138 of whom were men (49.6%). The men had a lower average age (63 vs. 68 years, p-value<0.001), had higher creatinine levels and higher diastolic blood pressure than the women (1.22±0.93 vs. 0.97±0.84 mg/dl, and 90±15 vs. 86±18 mmHg, all p-values<0.001). The mortality and S-ICH rates were comparable (2.3% vs. 5%, and 8.0% vs. 11.4%, respectively, all p-values>0.05). Having had a history of anti-platelet therapy was a strong risk factor for S-ICH in men (OR 6.43, 95% CI 1.39–29.69); whereas, age was significantly associated with mortality in women (OR 1.13, 95% CI 1.03–1.24). Conclusion: Men and women had similar rates of mortality and S-ICH after rt-PA. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41910614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Bassyouni, Fatma AboElnaga Ahmed, A. Ismaiel, A. Abdelmoneim, Haitham H Badran, M. E. El Zahry, R. Dwedar, A. Wegdan
Objective: To investigate the antifungal activity of voriconazole, with and without Kombucha tea culture, against Candida strains isolated from vulvovaginal candidiasis. Material and Methods: The study included 150 females, within child-bearing periods, complaining of valvovaginal candidiasis. Candida strains were isolated, and identified by conventional microbiological methods; and confirmed by Viteck-2 System. The sensitivity of the isolates to voriconazole was performed, via the Disc diffusion method. Resistant strains were then subjected to minimum inhibitory concentrations (MIC) investigation of voriconazole alone, and in combination with a Kombucha tea culture via the broth micro-dilution method in concentrations ranging from 0.0048 to 10 μg/ml. The ability of voriconazole, with and without Kombucha, to eradicate Candida biofilms were investigated using a crystal violet absorbance assay. Results: Eighty-nine strains were isolated. From these 60 isolates showed variable resistance patterns (57 were voriconazole resistant, and 3 had dose-dependent susceptability). Kombucha significantly decreased the MIC50 of voriconazole against all strains from 5 to 0.625 μg/ml (p-value<0.01); additionally, MIC90 were reduced from 10 to 1.25 μg/ml (p-value =0.000). Voriconazole at a concentration of 0.156 μg/ml succeeded in eradicating biofilms formed by 18 strains after adding a Kombucha tea supernatant versus zero strains when using Voriconazole alone. Conclusion: Kombucha Black tea cultures could be promising antifungal agents in the treatment of vulvovaginal candidiasis.
{"title":"In-vitro Antifungal Activities of Kombucha Tea Culture Supernatant Combined with Voriconazole against Vulvovaginal Candidiasis Clinical Isolates","authors":"R. Bassyouni, Fatma AboElnaga Ahmed, A. Ismaiel, A. Abdelmoneim, Haitham H Badran, M. E. El Zahry, R. Dwedar, A. Wegdan","doi":"10.31584/jhsmr.2023933","DOIUrl":"https://doi.org/10.31584/jhsmr.2023933","url":null,"abstract":"Objective: To investigate the antifungal activity of voriconazole, with and without Kombucha tea culture, against Candida strains isolated from vulvovaginal candidiasis. Material and Methods: The study included 150 females, within child-bearing periods, complaining of valvovaginal candidiasis. Candida strains were isolated, and identified by conventional microbiological methods; and confirmed by Viteck-2 System. The sensitivity of the isolates to voriconazole was performed, via the Disc diffusion method. Resistant strains were then subjected to minimum inhibitory concentrations (MIC) investigation of voriconazole alone, and in combination with a Kombucha tea culture via the broth micro-dilution method in concentrations ranging from 0.0048 to 10 μg/ml. The ability of voriconazole, with and without Kombucha, to eradicate Candida biofilms were investigated using a crystal violet absorbance assay. Results: Eighty-nine strains were isolated. From these 60 isolates showed variable resistance patterns (57 were voriconazole resistant, and 3 had dose-dependent susceptability). Kombucha significantly decreased the MIC50 of voriconazole against all strains from 5 to 0.625 μg/ml (p-value<0.01); additionally, MIC90 were reduced from 10 to 1.25 μg/ml (p-value =0.000). Voriconazole at a concentration of 0.156 μg/ml succeeded in eradicating biofilms formed by 18 strains after adding a Kombucha tea supernatant versus zero strains when using Voriconazole alone. Conclusion: Kombucha Black tea cultures could be promising antifungal agents in the treatment of vulvovaginal candidiasis.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47502073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Saengduenchai, S. Nilaban, Tanya Singtho, A. Ranuwattananon, R. Kalayasiri
Objective: The lack of a screening tool for substance use disorders is a significant problem for health care workers for patient care and referral. This study aimed to develop a Substance Use Disorder Screening Test (SUDST) to enable accurate classification of the severity of substance use disorders based on the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), that can be used by health professionals in all settings for basic screening for individuals at risk of substance use disorder. Material and Methods: Following close study of the DSM-5, 11 questions were developed, which were then tested on 207 participants who were receiving treatment for the use of methamphetamines. The participants were interviewed with the SUDST, the Ministry of Public Health Version 2 (normally ‘V.2’) screening test for risk of substance use, and were clinically diagnosed by their attending psychiatrist. Results: The Cronbach’s alpha coefficient for SUDST was 0.79. The scores obtained from the SUDST were in high agreement with the V.2 and clinical diagnosis (p-value<0.001). Factor analysis showed three components of substance use disorder: 1) preoccupation and loss of control, 2) risky/harmful use, and 3) biopsychosocial aspects. Of the total possible score of 11, the cut-off points for identifying severe, moderate, and mild levels of risk were ≥7, 5-6, and 3-4, respectively, with sensitivity=72.7%-96.5% and specificity=61.9%-88.7%. Conclusion: The SUDST had high reliability and validity and could be used to detect patients at risk of substance use disorders.
{"title":"Development and Validation of a New Substance Use Disorder Screening Test Based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)","authors":"S. Saengduenchai, S. Nilaban, Tanya Singtho, A. Ranuwattananon, R. Kalayasiri","doi":"10.31584/jhsmr.2023932","DOIUrl":"https://doi.org/10.31584/jhsmr.2023932","url":null,"abstract":"Objective: The lack of a screening tool for substance use disorders is a significant problem for health care workers for patient care and referral. This study aimed to develop a Substance Use Disorder Screening Test (SUDST) to enable accurate classification of the severity of substance use disorders based on the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), that can be used by health professionals in all settings for basic screening for individuals at risk of substance use disorder. Material and Methods: Following close study of the DSM-5, 11 questions were developed, which were then tested on 207 participants who were receiving treatment for the use of methamphetamines. The participants were interviewed with the SUDST, the Ministry of Public Health Version 2 (normally ‘V.2’) screening test for risk of substance use, and were clinically diagnosed by their attending psychiatrist. Results: The Cronbach’s alpha coefficient for SUDST was 0.79. The scores obtained from the SUDST were in high agreement with the V.2 and clinical diagnosis (p-value<0.001). Factor analysis showed three components of substance use disorder: 1) preoccupation and loss of control, 2) risky/harmful use, and 3) biopsychosocial aspects. Of the total possible score of 11, the cut-off points for identifying severe, moderate, and mild levels of risk were ≥7, 5-6, and 3-4, respectively, with sensitivity=72.7%-96.5% and specificity=61.9%-88.7%. Conclusion: The SUDST had high reliability and validity and could be used to detect patients at risk of substance use disorders.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41304322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sirikarn Siripruekpong, A. Geater, S. Cheewatanakornkul
Objective: To compare masked uncontrolled hypertension (MUCH) (n=16) and adequately controlled hypertension (ACH) (n=21) patients regarding their haemodynamic response to induction, incision and extubation, and evaluate the risk of perioperative recurrent adverse cardiovascular events in a prospective observational study. Material and Methods: After home blood pressure (BP) monitoring, patients were classified as MUCH or ACH using objective criteria. Perioperative haemodynamic parameters were monitored. Recurrent adverse event risks were evaluated using total-time and gap-time recurrent-event analysis. Results: BP responses to induction were qualitatively similar in the two groups, but with an exaggerated response following incision and extubation in the MUCH group. Risks of recurrent hypertensive events were higher in MUCH than in ACH patients during the intraoperative and emergence periods, with hazard ratios [95% confidence intervals] of 2.10 [1.21, 3.64] and 4.73 [1.12, 19.89] from total-time models, and 1.84 [1.20, 2.84] and 5.91 [1.45, 24.11] from gap-time models; the risk of recurrent bradycardia was higher during emergence, 4.08 [1.22, 13.59] from total-time and 4.88 [1.77, 13.45] from gap-time models. In contrast, the risk of recurrent hypotension was significantly lower in the MUCH patients during induction. Conclusion: Compared to ACH, MUCH patients were at increased risk of recurrent hypertensive events during the intraoperative and emergence periods, and of recurrent bradycardia during emergence.
{"title":"Effect of Masked Uncontrolled Hypertension on Perioperative Haemodynamic Response and Recurrent Adverse Cardiovascular Events among Patients Undergoing Major Noncardiac Surgery","authors":"Sirikarn Siripruekpong, A. Geater, S. Cheewatanakornkul","doi":"10.31584/jhsmr.2023931","DOIUrl":"https://doi.org/10.31584/jhsmr.2023931","url":null,"abstract":"Objective: To compare masked uncontrolled hypertension (MUCH) (n=16) and adequately controlled hypertension (ACH) (n=21) patients regarding their haemodynamic response to induction, incision and extubation, and evaluate the risk of perioperative recurrent adverse cardiovascular events in a prospective observational study. Material and Methods: After home blood pressure (BP) monitoring, patients were classified as MUCH or ACH using objective criteria. Perioperative haemodynamic parameters were monitored. Recurrent adverse event risks were evaluated using total-time and gap-time recurrent-event analysis. Results: BP responses to induction were qualitatively similar in the two groups, but with an exaggerated response following incision and extubation in the MUCH group. Risks of recurrent hypertensive events were higher in MUCH than in ACH patients during the intraoperative and emergence periods, with hazard ratios [95% confidence intervals] of 2.10 [1.21, 3.64] and 4.73 [1.12, 19.89] from total-time models, and 1.84 [1.20, 2.84] and 5.91 [1.45, 24.11] from gap-time models; the risk of recurrent bradycardia was higher during emergence, 4.08 [1.22, 13.59] from total-time and 4.88 [1.77, 13.45] from gap-time models. In contrast, the risk of recurrent hypotension was significantly lower in the MUCH patients during induction. Conclusion: Compared to ACH, MUCH patients were at increased risk of recurrent hypertensive events during the intraoperative and emergence periods, and of recurrent bradycardia during emergence.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47381295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pattira Boonsri, Takeshi Fukada, L. J. Prahaspathiji, Min Huang
Objective: To evaluate the correlation between the clinical course of chronic recurrent multifocal osteomyelitis (CRMO) lesions and their imaging characteristics on follow-up MRIs. Material and Methods: Two musculoskeletal fellowship-trained radiologists retrospectively reviewed the initial and follow-up MRI images of 9 CRMO patients who were treated in our institution from 2008 to 2018. Evaluation of clinical course was based on symptomatology, lab results and physical examination and was compared to MRI findings, on follow-up MRIs. Results: Thirty-five CRMO lesions in 9 patients were identified. Patient’s ages ranged from 4 to 15 years with a mean age of 10 years (S.D.±3.22). Six of the 9 patients were female. Only 21 of 35 lesions had been longitudinally followed by MRI. Of the 39 follow-up MRI exams, there was clinical improvement 15 times, and 24 times there was no clinical improvement confirmed by the clinician. Three MRI features: 1) bone marrow edema (BME) size, 2) BME signal intensity and 3) periosteal edema, significantly correlated with the clinical course (p-value<0.001). When there was the improvement of all these three findings, the correlation with clinical improvement was high with 80% sensitivity and 100% specificity. The area under the receiver operator characteristic curve was 0.90 (95% confidence interval 0.795-1.005). Fourteen silent clinical lesions were also identified. Conclusion: Bone marrow edema and periosteal edema correlated best with the clinical course of CRMO patients on follow-up MRIs.
{"title":"Correlation between the Clinical Course of CRMO Lesions and the Imaging Characteristics on Follow-up MRIs","authors":"Pattira Boonsri, Takeshi Fukada, L. J. Prahaspathiji, Min Huang","doi":"10.31584/jhsmr.2023929","DOIUrl":"https://doi.org/10.31584/jhsmr.2023929","url":null,"abstract":"Objective: To evaluate the correlation between the clinical course of chronic recurrent multifocal osteomyelitis (CRMO) lesions and their imaging characteristics on follow-up MRIs. Material and Methods: Two musculoskeletal fellowship-trained radiologists retrospectively reviewed the initial and follow-up MRI images of 9 CRMO patients who were treated in our institution from 2008 to 2018. Evaluation of clinical course was based on symptomatology, lab results and physical examination and was compared to MRI findings, on follow-up MRIs. Results: Thirty-five CRMO lesions in 9 patients were identified. Patient’s ages ranged from 4 to 15 years with a mean age of 10 years (S.D.±3.22). Six of the 9 patients were female. Only 21 of 35 lesions had been longitudinally followed by MRI. Of the 39 follow-up MRI exams, there was clinical improvement 15 times, and 24 times there was no clinical improvement confirmed by the clinician. Three MRI features: 1) bone marrow edema (BME) size, 2) BME signal intensity and 3) periosteal edema, significantly correlated with the clinical course (p-value<0.001). When there was the improvement of all these three findings, the correlation with clinical improvement was high with 80% sensitivity and 100% specificity. The area under the receiver operator characteristic curve was 0.90 (95% confidence interval 0.795-1.005). Fourteen silent clinical lesions were also identified. Conclusion: Bone marrow edema and periosteal edema correlated best with the clinical course of CRMO patients on follow-up MRIs.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47748749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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