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Predictors of Nonadherence to Planned Coronary Angiography: A Retrospective Analysis 不遵守计划冠状动脉造影的预测因素:回顾性分析
Q4 Medicine Pub Date : 2023-04-25 DOI: 10.31584/jhsmr.2023949
Sutida Petsuwan, K. Maneewat, W. Sae-Sia, V. Chittithavorn
Objective: This study aimed to determine the predictive power of patient-related factors, socio-economic factors, condition-related factors, treatment-related factors, and health care system-related factors for nonadherence to planned coronary angiography (CAG). Material and Methods: A retrospective analysis was conducted on electronic medical records (EMR) of 665 patients appointed for elective CAG at Naradhiwas Rajanagarindra Heart Center from January 2018 to December 2019. One hundred and thirty-three patients with nonadherence to planned CAG were assigned to the study group; the control group consisted of 532 patients with adherence to planned CAG. Results: The retrospective data analysis revealed that divorced or widowed status (OR=3.07; 95% CI 1.54, 6.12), cerebrovascular disease comorbidity (OR=4.37; 95% CI 1.74, 10.96), prescribed diuretics (OR=2.24; 95% CI 1.26, 3.97), CAG wait time three months or longer (OR=3.34; 95% CI 1.46, 7.64) and history of parental cardiovascular disease or death from heart disease (OR=0.12; 95% CI 0.01, 0.95) were co-predictors of nonadherence to planned CAG. Socioeconomic- related factors had no predictive power for planned CAG nonadherence. Conclusion: The findings of this study may contribute to the improvement of nursing service by screening groups at high risk of nonadherence and developing appropriate interventions aimed at increasing adherence to planned CAG as well the rate of positive health outcomes.
目的:本研究旨在确定患者相关因素、社会经济因素、病情相关因素、治疗相关因素和医疗保健系统相关因素对不遵守计划冠状动脉造影(CAG)的预测能力。材料和方法:对2018年1月至2019年12月在Naradhiwas-Rajanagarindra心脏中心接受选择性CAG的665名患者的电子病历(EMR)进行回顾性分析。133名不遵守计划CAG的患者被分配到研究组;对照组由532名坚持计划CAG的患者组成。结果:回顾性数据分析显示,离婚或丧偶状态(or=3.07;95%CI 1.54,6.12)、脑血管病合并症(or=4.37;95%CI 1.74,10.96)、处方利尿剂(or=2.24;95%CI1.26,3.97)、,CAG等待时间三个月或更长(or=3.34;95%CI 1.46,7.64)和父母有心血管疾病或心脏病死亡史(or=0.12;95%CI 0.01,0.95)是不遵守计划CAG的共同预测因素。社会经济相关因素对计划CAG不依从性没有预测力。结论:本研究的结果可能有助于通过筛查高危不依从人群和制定适当的干预措施来改善护理服务,以提高对计划CAG的依从性和阳性健康结果的发生率。
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引用次数: 0
Correlation between Initial International Prostate Symptom Score (IPSS) and Complications of Benign Prostatic Hyperplasia 初始国际前列腺症状评分(IPSS)与良性前列腺增生并发症的相关性
Q4 Medicine Pub Date : 2023-04-18 DOI: 10.31584/jhsmr.2023948
Santapon Chamnarnprai, Keerati Laowanichwith, Akachai Sinsophonphap, Nol Chuntanaparb, Chatporn Boonyapalanant
Objective: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, and some of them are suffering from its complications. Early detection and management of complications of BPH will lead to optimal results of treatment. The International Prostate Symptom Score (IPSS) is a disease and symptom-specific scoring system used for initial evaluations of BPH patients. This study aims to determine the correlation between initial IPSS and complications resulting from BPH. Material and Methods: This hospital-based cross-sectional study enrolled all male patients, aged 60 years and above having complained of lower urinary tract symptoms (LUTS), at the outpatient clinic. Patients’ demographic data (age), IPSS, and history of complications from BPH; including urinary tract infection (UTI), hematuria, urinary retention and prostate related surgery were collected. Results: In total, 301 patients were recruited in this study, with a mean age of 70.1 years old. There was significant correlation between age and IPSS (p-value 0.034), by using correlation coefficients. Sub-group analysis demonstrates a significant correlation of IPSS (both mean and severity group classifications) and complications from BPH (UTI, hematuria, urinary retention, and prostate surgery due to BPH) (p-value<0.001). Conclusion: The rate of complications, due to BPH including UTI, hematuria, urinary retention, and BPH-related surgery, correlate with higher initial IPSS. 
目的:良性前列腺增生症(BPH)是老年男性的常见病,部分患者存在并发症。早期发现和处理前列腺增生并发症将带来最佳的治疗效果。国际前列腺症状评分(IPSS)是一种用于对前列腺增生患者进行初步评估的疾病和症状特异性评分系统。本研究旨在确定初始IPSS与前列腺增生并发症之间的相关性。材料和方法:这项基于医院的横断面研究纳入了门诊部所有患有下尿路症状(LUTS)的60岁及以上男性患者。患者的人口统计学数据(年龄)、IPSS和前列腺增生并发症史;包括尿路感染(UTI)、血尿、尿潴留和前列腺相关手术。结果:本研究共招募301名患者,平均年龄70.1岁。使用相关系数,年龄与IPSS之间存在显著相关性(p值0.034)。亚组分析显示,IPSS(平均组和严重组分类)与前列腺增生并发症(尿路感染、血尿、尿潴留和前列腺增生引起的前列腺手术)显著相关(p值<0.001)。
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引用次数: 0
Pre-epiglottic Space and Epiglottis to Vocal Cord Ratio in Order to Predict Difficult Intubation in Adults: A Multivariate Analysis 预测成人插管困难的会厌前间隙和声门与声带比率的多变量分析
Q4 Medicine Pub Date : 2023-04-12 DOI: 10.31584/jhsmr.2023947
Objective: We aimed to enhance the prediction of difficult intubation by using ultrasonographic parameters (pre-epiglottic space (Pre-E), distance between epiglottis to middle part of vocal cord (E-VC) and Pre-E/E-VC) adjusting for traditional airway assessments. Material and Methods: This prospective cohort study was conducted at a super-tertiary care hospital in Thailand. Participants aged 18-65 years with ASA classification I-III and who required general anesthesia with endotracheal intubation were included. Preoperative traditional and ultrasonographic airway assessments were performed by two investigators. The outcome was difficult intubations as diagnosed by laryngoscopic view grade 3 or 4. Multivariate logistic regression was used to identify predictors for difficult intubation presented by adjusted odds ratio (OR) and 95% confidence interval (CI). Results: A total of 94 patients were recruited. The incidence of difficult intubation was 15%. The median Pre-E/E-VC ratio among this group was 0.8 compared with 1.0 in the control group (p-value 0.124). The cut-off point of <1.0 of Pre- E/E-VC was not associated with difficult intubation after adjusting for sex and other traditional parameters (p-value 0.11). Predictors of difficult intubation were female sex (OR [95% CI]: 13.8 [2.8, 68.3]), sternomental distance ≤175 mm (OR [95% CI]: 11.6 [1.9, 71.4]) and interincisor gap <4 cm (OR [95% CI]: 19.8 [1.1, 373.8]) with the area under the receiver operating characteristic curve at 0.88 and a specificity of 90.0%. Conclusion: There was no association between the Pre-E/E-VC in predicting difficult intubation in low-risk patients. The ultrasonographic measurements of Pre-E/E-VC were not helpful in predicting difficult intubations in our setting. Trial registration: thaiclinicaltrials.org: TCTR20180115002, Registered 9 January 2018 - Prospectively registered, https:// www.thaiclinicaltrials.org/#
目的:我们旨在通过调整传统气道评估的超声参数(会厌前间隙(pre-E)、会厌至声带中部的距离(E-VC)和pre-E/E-VC)来增强对困难插管的预测。材料和方法:这项前瞻性队列研究在泰国的一家超三级护理医院进行。参与者年龄为18-65岁,ASA分类为I-III,需要气管插管全身麻醉。两名研究人员进行了术前传统和超声气道评估。结果是插管困难,喉镜检查为3级或4级。多变量逻辑回归用于确定由调整比值比(OR)和95%置信区间(CI)表示的插管困难的预测因素。结果:共招募了94名患者。插管困难的发生率为15%。该组的Pre-E/E-VC比值中值为0.8,而对照组为1.0(p值0.124)。在调整性别和其他传统参数后,Pre-E/E/VC的临界点<1.0与插管困难无关(p值0.11)。插管困难的预测因素为女性(OR[95%CI]:13.8[2.8,68.3]),胸网膜距离≤175mm(OR[95%CI]:11.6[1.9,71.4]),膈间隙<4cm(OR[95%CI]:19.8[1.3738]),受试者操作特征曲线下面积为0.88,特异性为90.0%。在我们的环境中,Pre-E/E-VC的超声测量对预测困难的插管没有帮助。试验注册:thaiclinicaltrials.org:TCTR20180115002,2018年1月9日注册-前瞻性注册,https://www.thaiclinialtrials.org/#
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引用次数: 0
Assessment of Oral Health Status among the Kutia Kandha Tribe - A Particularly Vulnerable Group Residing in Kandhamal District, Odisha 居住在奥里萨邦Kandhamal区的Kutia Kandha部落的口腔健康状况评估
Q4 Medicine Pub Date : 2023-03-30 DOI: 10.31584/jhsmr.2023946
Payal Dash, G.Ranjith Kumar
Objective: In Odisha, the Kandha tribal group is numerically the most populous tribe. Among the several sections of the Kandha communities, two sub-sections, the Kutia Kandha and Dongria Kandha, have been identified as Particularly Vulnerable Tribal Groups (PVTGs). As a result, the study’s aim was to assess the oral health status of the Kutia Kandha tribe. Material and Methods: A cross-sectional survey was carried out among 850 Kutia Kandhas using a multistage randomised sampling method in the Tumudibandha Block of Kandhamal District. Data were collected using the World Health Organization (WHO) Oral Health Assessment Form, 2013. Numbers and percentages were analyzed using Microsoft Excel and Statistical Package for the Social Science (SPSS) package version 26.0. Comparisons between discrete and continuous data were done using the Chi-square test and ANOVA. A p-value of 0.05 was considered to be statistically significant. Results: The study population consisted of 850 subjects stratified into seven different age groups. The mean DMFT (permanent) and dmft (deciduous) scores of were 4.06±3.55 and 0.12±0.56 respectively. One hundred fifty-one (16.0%) subjects had bleeding. Three hundred and sixty-two (42.6%) subjects had pockets 4-6 mm and 276 (32.5%) had pockets more than 6 mm. Four hundred and seventy-six (56%) of the study participants had 4-5 mm of loss of attachment followed by 303 (35.6%) with 6-8 mm loss of attachment. Conclusion: The prevalence of caries and periodontal diseases was high. Due to a lack of knowledge about oral hygiene maintenance, proper health education should be provided to the Kutia Kandha tribals.
目的:在奥里萨邦,Kandha部落是人口最多的部落。在Kandha社区的几个部分中,Kutia Kandha和Dongria Kandha这两个分支被确定为特别脆弱的部落群体。因此,这项研究的目的是评估库蒂亚坎德哈部落的口腔健康状况。材料和方法:在坎达马区Tumudibandha街区,采用多阶段随机抽样方法对850名库蒂亚坎达人进行了横断面调查。数据采用2013年世界卫生组织(WHO)口腔健康评估表收集。使用Microsoft Excel和SPSS 26.0版社会科学统计软件包(Statistical Package for Social Science, SPSS)对数字和百分比进行分析。使用卡方检验和方差分析对离散和连续数据进行比较。p值为0.05被认为具有统计学意义。结果:研究人群包括850名受试者,分为7个不同年龄组。两组的DMFT(恒牙)和DMFT(乳牙)平均评分分别为4.06±3.55和0.12±0.56。151例(16.0%)出现出血。362例(42.6%)患者口袋大小为4-6 mm, 276例(32.5%)患者口袋大小大于6 mm。476人(56%)有4-5毫米的依恋缺失,303人(35.6%)有6-8毫米的依恋缺失。结论:本区龋、牙周病患病率较高。由于缺乏口腔卫生知识,应向库蒂亚坎德哈部落提供适当的健康教育。
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引用次数: 0
Immunometabolic Profile of Nigerian COVID-19 Patients 尼日利亚COVID-19患者免疫代谢谱
Q4 Medicine Pub Date : 2023-03-28 DOI: 10.31584/jhsmr.2023945
G. Arinola, A. A. Onifade, V. F. Edem, S. Rahamon, O. Alonge
Objective: Existence of crosstalk between metabolic and immune response against severe, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicates that its full understanding could facilitate therapeutic insights for Coronavirus disease 2019 (COVID-19) management. Therefore, selected immunometabolic indices were determined in COVID-19 patients at a Nigerian Isolation Centre. Material and Methods: Haematological parameters (Total White Blood Cell [TWBC] and Differential White Blood Cell Counts), inflammation indices (C-Reactive Protein [CRP], Albumin, Pre-albumin and Neutrophil/Lymphocyte ratio [NLR]), anti-SARS-CoV-2 specific immunoglobulin (Ig) M and IgG, respiratory burst factors, lipid profile as well as renal and liver functions were determined in COVID-19 patients and controls. Results: Seventy percent of the COVID-19 patients were less than 40 years of age and largely had mild COVID-19. The mean TWBC, neutrophil, NLR and CRP levels were significantly higher, while the lymphocyte count was significantly lower in COVID-19 patients compared with the controls. Also, the mean plasma levels of anti-SARS-CoV-2 specific IgG and IgM in addition to superoxide dismutase (SOD) activity were significantly higher, while the mean plasma levels of nitric oxide, hydrogen peroxide and myeloperoxidase activity were significantly lower in COVID-19 patients compared with the controls. High proportions of COVID-19 patients had values of the liver (59%-96%) and renal (43%-97%) function test parameters within the normal reference intervals. Similarly, high proportions of COVID-19 patients had values of lipid profile (71%-86%) within the normal reference intervals. Conclusion: The infrequent alteration in lipid metabolism as well as liver and renal functions suggest mild COVID-19. However, hyper-inflammation remains a significant observation in COVID-19 patients, irrespective of the form of the disease.
目的:针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的代谢和免疫反应之间存在串扰,这表明对其的充分理解可以促进对2019冠状病毒病(新冠肺炎)管理的治疗见解。因此,在尼日利亚隔离中心确定了新冠肺炎患者的选定免疫代谢指标。材料和方法:血液学参数(总白细胞[TWBC]和差异白细胞计数)、炎症指数(C-反应蛋白[CRP]、白蛋白、前白蛋白和中性粒细胞/淋巴细胞比率[NLR])、抗严重急性呼吸系统综合征冠状病毒2型特异性免疫球蛋白(Ig)M和IgG、呼吸爆发因子,测定了新冠肺炎患者和对照组的血脂状况以及肾和肝功能。结果:70%的新冠肺炎患者年龄在40岁以下,主要患有轻度新冠肺炎。与对照组相比,新冠肺炎患者的平均TWBC、中性粒细胞、NLR和CRP水平显著升高,淋巴细胞计数显著降低。此外,与对照组相比,新冠肺炎患者的抗SARS-CoV-2特异性IgG和IgM的平均血浆水平以及超氧化物歧化酶(SOD)活性均显著升高,而一氧化氮、过氧化氢和髓过氧化物酶活性的平均血浆平均显著降低。高比例的新冠肺炎患者的肝(59%-96%)和肾(43%-97%)功能测试参数值在正常参考区间内。同样,高比例的新冠肺炎患者的脂质分布值(71%至86%)在正常参考区间内。结论:脂质代谢以及肝脏和肾脏功能的罕见变化表明轻度新冠肺炎。然而,无论疾病形式如何,新冠肺炎患者的过度炎症仍然是一个重要的观察结果。
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引用次数: 0
Epidemiology of Burn Injury in the Southern Border Provinces of Thailand 泰国南部边境省份烧伤流行病学研究
Q4 Medicine Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023942
Saranyoo Suwansa-Ard
Objective: This study aimed to investigate burns, from any situation, and the treatment in the Burn Center of Yala Hospital. Material and Methods: This research was a retrospective study in the Burn Center of Yala Hospital; from April 1, 2019 to May 31, 2021. Results: Enrollment consisted of 161 burn patients (male 65.8%, female 34.2%). Most burns in children were scalds (67.3%); whereas, in adults and the elderly they were flame burns (51.0% in adults and 66.7% in the elderly) (p-value<0.001), which were usually <20% of total body surface area (p-value<0.001). Most burns were superficial second degree burns. Patients in all age groups required surgical intervention (p-value=0.003). The median length of hospital stay was approximately seven days (IQR4-17); however, the elderly required intensive care more often than other age groups (p-value=0.003). All enrolled cases survived. Conclusion: The most common cause of burns in adults and the elderly was burning from flames, while burns from scalds occurred most in children. Burns in the elderly were more severe, and required admission to the intensive care unit more than any other age group.
目的:了解雅拉医院烧伤中心各种情况下的烧伤及治疗情况。材料与方法:本研究是在雅拉医院烧伤中心进行的回顾性研究;2019年4月1日至2021年5月31日。结果:入组161例烧伤患者(男性65.8%,女性34.2%)。儿童烧伤以烫伤为主(67.3%);而成人和老年人以火焰烧伤为主(成人51.0%,老年人66.7%)(p值<0.001),火焰烧伤通常小于体表面积的20% (p值<0.001)。大多数烧伤是浅二度烧伤。所有年龄组的患者均需要手术干预(p值=0.003)。中位住院时间约为7天(IQR4-17);然而,老年人比其他年龄组更需要重症监护(p值=0.003)。所有入组病例均存活。结论:成人和老年人烧伤以火焰烧伤为主,儿童烧伤以烫伤烧伤为主。老年人的烧伤更为严重,比其他年龄组更需要进入重症监护病房。
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引用次数: 0
Validity and Reliability of the Vietnamese Version of Diabetic Selfcare Knowledge Questionnaire-30 Used for Assessing Self-care Knowledge of Patients with Type 2 Diabetes Mellitus in Vietnam 越南版糖尿病自我护理知识问卷-30用于评估越南2型糖尿病患者自我护理知识的有效性和可靠性
Q4 Medicine Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023943
Phung Van Loi, Ngô Huy Hoàng, Pham Tuan Vu, Dao Thanh Xuyen
Objectives: To translate and adapt the Diabetic Self-care Knowledge Questionnaire-30 (DSCKQ-30) questionnaire to be suitable for Vietnamese conditions and culture. To examine the reliability and validity of the Vietnamese version of the DSCKQ-30 questionnaire. Material and Methods: The questionnaire was forward translated, from English into Vietnamese and vice versa, by four independent translators. After that, an expert panel resolved any disagreements in translation regarding 4 criteria: semantics, idioms, experiences and concepts. The questionnaire then underwent a pilot study, on a sample of 100 DM patients to assess its clarity and readability; from June 1, 2021, to June 15, 2021. Finally, a test-retest study was conducted on a sample of 279 patients, over one month to examine internal consistency, stability and construct validity of the questionnaire; from July 1, 2021 to July 30, 2021. This study was approved by the Research Ethics Committee of the Thai Nguyen National Hospital. Results: The Vietnamese translated diabeté self-care knowledge questionnaire had content validity of 1.00, Cronbach’s alpha of 0.899 and Kappa coefficient of 0.700 or greater, except for question 15: with a Kappa coefficient of 0.658 (acceptable). Conclusion: The translated, adapted version of the DSCKQ-30 is valid, reliable and a feasible tool for practice, education and research in the future.
目的:翻译和调整糖尿病自我保健知识问卷-30 (DSCKQ-30),使其适合越南的条件和文化。检验越南版DSCKQ-30问卷的信度和效度。材料与方法:问卷由四名独立翻译人员从英语翻译成越南语,反之亦然。之后,一个专家小组就语义、习语、经验和概念4个标准解决了翻译中的任何分歧。然后对100名糖尿病患者进行了问卷调查,以评估其清晰度和可读性;2021年6月1日至2021年6月15日。最后,对279例患者进行为期一个多月的重测研究,检验问卷的内部一致性、稳定性和结构效度;从2021年7月1日到2021年7月30日。本研究已获泰国国立医院研究伦理委员会批准。结果:越南语翻译的糖尿病患者自我保健知识问卷的内容效度为1.00,Cronbach 's alpha为0.899,Kappa系数为0.700以上,除第15题Kappa系数为0.658(可接受)外。结论:翻译改编版的DSCKQ-30量表有效、可靠,是今后实践、教育和研究的可行工具。
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引用次数: 0
Assessment of Surgery and Anesthesia Services and Patients’ Attitude Towards Informed Consent: The Case of a Specialized and Comprehensive University Hospital in Northern Ethiopia 手术和麻醉服务与患者知情同意态度的评估——以埃塞俄比亚北部一所专业综合大学医院为例
Q4 Medicine Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023944
Mussie Tesfay Atsbeha, Mengistu Mitiku
Objective: Healthcare providers need to establish close relationships with patients planning to undergo major elective surgery as this helps produce positive patient outcomes. This study aimed at investigating surgery and anesthesia services and patients’ attitude toward informed consent at Ayder comprehensive specialized university hospital, in Northern Ethiopia. Material and Methods: A facility-based cross-sectional study was conducted in the biggest health facility in Northern Ethiopia. Four hundred ten patients with major elective surgery were recruited. A structured questionnaire was used to collect socio-demographics, anesthesia and surgery services and the attitude of patients toward informed consent. Descriptive results were presented using frequencies and tables. Regression analysis was accompanied by an odds ratio and a 95% confidence interval was run to identify factors associated with the outcome variable. Results: Study participants’ mean age was 36.1+11.7. Around two-thirds (71.7%) and one-fourth (26.6%) of the study participants were informed about their proposed surgical procedure and its possible complications, respectively. Two hundred ninety four (66.8%) and 88 (21.5%) were made aware of the type of anesthesia that was going to be administered and possible complications. About half (50.7%) had expressed a positive attitude towards informed consent. Rural residents have about twice (AOR=1.9; 95% CI: 1.06-2.73) higher odds of expressing a positive attitude towards the informed consent than their counterparts. Conclusion: The study revealed that the proportion of patients who were informed about their anesthesia-surgery services was moderate. Besides, patients’ attitude toward informed consent was poor. The residence was a good predictor of positive patients’ attitudes toward informed consent. Thus, healthcare professionals in the surgery department should establish clear and transparent communication with patients about surgery and anesthesia-related services.
目的:医疗保健提供者需要与计划接受重大选择性手术的患者建立密切的关系,因为这有助于产生积极的患者结果。本研究的目的是调查手术和麻醉服务和患者对知情同意的态度在艾德尔综合专科大学医院,在埃塞俄比亚北部。材料和方法:在埃塞俄比亚北部最大的卫生机构进行了一项基于设施的横断面研究。我们招募了410名接受择期大手术的患者。采用结构化问卷收集社会人口统计学、麻醉和手术服务以及患者对知情同意的态度。描述性结果使用频率和表格呈现。采用比值比进行回归分析,并采用95%置信区间确定与结果变量相关的因素。结果:研究参与者的平均年龄为36.1+11.7岁。大约三分之二(71.7%)和四分之一(26.6%)的研究参与者分别被告知他们拟议的手术程序及其可能的并发症。294例(66.8%)和88例(21.5%)患者了解麻醉方式和可能出现的并发症。约一半(50.7%)受访者对知情同意持积极态度。农村居民约为2倍(AOR=1.9;95% CI: 1.06-2.73)对知情同意表达积极态度的几率高于同行。结论:本研究显示,被告知麻醉手术服务的患者比例适中。此外,患者对知情同意的态度较差。居住是一个很好的预测积极的病人对知情同意的态度。因此,外科医护人员应与患者就手术及麻醉相关服务建立清晰透明的沟通。
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引用次数: 0
Assessment of Prosthetic Status and Oral Frailty among The Geriatric Population Residing in Old Age Homes of Bhubaneswar City-a Cross Sectional Study 居住在布巴内斯瓦尔市养老院的老年人口中假肢状态和口腔虚弱的评估-一项横断面研究
Q4 Medicine Pub Date : 2023-03-16 DOI: 10.31584/jhsmr.2023941
G. Kumar, Payal Dash, Samikshya Jena
Objective: The aim of this study was to assess the prosthetic status and oral frailty of the elderly population residing in old age homes of Bhubaneswar city. Material and Methods: A cross-sectional questionnaire study was conducted among 310 geriatric patients aged 60 years and above residing in old age homes of Bhubaneswar city. Data collection was done using a modified World Health Organization (WHO) 1997 and oral frailty index 8. Descriptive statistics, chi-square test, Pearsons correlation and multinomial logistic regression were used. Results: The mean age of the study population was 66.72±6.86 years. Forty-seven percent of the study population required multiple units in the upper arch and approximately 30% in the lower arch. There was a significant positive correlation between the prosthetic status of the upper teeth and oral frailty (Pearson correlation coefficient: 0.315, p-value <0.0001). A ~1.751-fold risk of oral frailty was detected in participants with increasing age (p-value=0.049). Conclusions: The results of this study suggest that most of the need for prostheses in the aged population was inadequate. 
目的:本研究的目的是评估居住在布巴内斯瓦尔市养老院的老年人口的假肢状态和口腔虚弱。材料与方法:对布巴内斯瓦尔市养老院的310名60岁及以上老年患者进行了横断面问卷调查。数据收集使用经修订的1997年世界卫生组织(WHO)和口腔虚弱指数8。采用描述性统计、卡方检验、pearson相关及多项logistic回归分析。结果:研究人群平均年龄为66.72±6.86岁。47%的研究对象需要多个上弓单元,大约30%需要下弓单元。上牙修复状态与口腔脆弱程度呈正相关(Pearson相关系数:0.315,p值<0.0001)。随着年龄的增长,口腔虚弱的风险为1.751倍(p值=0.049)。结论:本研究结果表明,大多数老年人对义肢的需求不足。
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引用次数: 0
Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation 儿童结核患者血清白细胞介素-12和干扰素γ水平:临床微生物学相关性
Q4 Medicine Pub Date : 2023-03-13 DOI: 10.31584/jhsmr.2023940
N. Gupta, B. Kashyap, P. Dewan, Puneeta Hyanki
Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine pathway regulating Mycobacterium tuberculosis infection. The role of IL-12/IFN-γ axis in protecting against tuberculosis (TB) is exhibited in people having mutations in genes encoding these cytokines. We aimed to study the serum levels of IL-12 and IFN-γ in pediatric tuberculosis and their correlation with clinical and microbiological features. Material and Methods: A case-control study was conducted on 60 microbiologically confirmed (smear and/or culture and/or cartridge-based nucleic acid amplification test) or clinically diagnosed (based on clinical features and radiography and/or contact history and/or Mantoux test with/without microbiological confirmation) pediatric TB patients ≤12 years. Serum interleukin-12 and interferon-gamma levels were estimated using enzyme-linked immunosorbent assays.Thirty age- and sex-matched controls were also included in the study. Results: The median IL-12 levels were lower in our pediatric TB patients (488.1 pg/ml) compared to controls (784.8 pg/ml). However, the IFN-γ/IL-12 ratios were significantly higher among the TB patients as compared to the controls. Moreover, the levels of interleukin-12 and interferon gamma were significantly lower in cases with no evidence of TB on chest radiography. IL-12 was significantly lower in patients with hydrocephalus and enlarged ventricles. Higher levels of IL-12 and IFN-γ were associated with positive results by conventional microbiological techniques. Conclusion: The serum IFN-γ level and the IFN-γ/IL-12 ratio were significantly higher in children with TB compared to the controls in this study. Higher IL-12 and IFN-γ levels as well as IFN-γ/IL-12 ratios were associated with positive results by conventional microbiological techniques. Further studies on larger sample sizes could help evaluate the usefulness of interleukin-12 and interferon-γ as potential markers of severity and prognosis in pediatric TB. 
目的:白细胞介素-12/干扰素-γ(IL-12/IFN-γ)途径是最有效的调节结核分枝杆菌感染的细胞因子途径。IL-12/IFN-γ轴在预防结核病(TB)中的作用表现在编码这些细胞因子的基因发生突变的人身上。我们旨在研究儿童结核病患者血清IL-12和IFN-γ水平及其与临床和微生物学特征的相关性。材料和方法:对60名≤12岁的经微生物学证实(涂片和/或培养和/或卡式核酸扩增试验)或临床诊断(基于临床特征和放射学和/或接触史和/或Mantoux试验,有/无微生物证实)的儿童结核病患者进行病例对照研究。血清白细胞介素-12和干扰素γ水平采用酶联免疫吸附测定法进行评估。30名年龄和性别匹配的对照也被纳入研究。结果:与对照组(784.8 pg/ml)相比,我们的儿科结核病患者的中位IL-12水平(488.1 pg/ml)较低。然而,与对照组相比,结核病患者的IFN-γ/IL-12比值显著较高。此外,在胸部放射检查中没有结核病证据的病例中,白细胞介素-12和干扰素γ的水平显著降低。IL-12在脑积水和脑室扩大的患者中显著降低。通过常规微生物学技术,较高水平的IL-12和IFN-γ与阳性结果相关。结论:结核病患儿血清IFN-γ水平及IFN-γ/IL-12比值明显高于对照组。通过常规微生物学技术,较高的IL-12和IFN-γ水平以及IFN-γ/IL-12比率与阳性结果相关。对更大样本量的进一步研究有助于评估白细胞介素-12和干扰素-γ作为儿童结核病严重程度和预后的潜在标志物的有用性。
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Journal of Health Science and Medical Research
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