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Modelling seizure-related predictors of epilepsy diagnostic gap in two urban informal settlements of Nairobi using machine learning 利用机器学习对内罗毕两个城市非正式住区癫痫诊断差距的癫痫相关预测因素进行建模
Pub Date : 2025-12-29 DOI: 10.1016/j.gloepi.2025.100241
Daniel Mwanga , Frederick Murunga Wekesah , Frank Ouma , Symon M. Kariuki , Joan Kinuthia , Peter Otieno , Thomas Kwasa , Quincy Mongare , Abigael Machuka , Steve Cygu , Samuel Iddi , Gabriel Davis Jones , Arjune Sen , Charles R. Newton , Gershim Asiki , Damazo T. Kadengye , for the EPInA Study Group

Background

There is a wide gap in epilepsy diagnosis, particularly in low- and middle-income countries. We used machine learning models to identify seizure-related factors associated with the epilepsy diagnostic gap within the Nairobi Urban Health and Demographic Surveillance System (NUHDSS), Kenya, to inform effective community-level interventions.

Methods

Data were drawn from a two-stage, population-based census. In Stage-I, 56,425 residents of NUHDSS were screened for possible convulsive and non-convulsive epilepsy using a standardized questionnaire. In Stage-II, individuals who screened positive were invited for clinical assessment and diagnostic confirmation by neurologists. We used latent class analysis to classify symptom patterns. Seven machine learning models were trained, with extreme gradient boost and random forest models achieving the highest area under the receiver operating characteristic curve (98 %).

Results

A total of 528 individuals were diagnosed with epilepsy, among whom 80 % (n = 420) had not been previously diagnosed. The epilepsy diagnostic gap was 100 % (n = 160/160) in persons with non-convulsive epilepsy, meaning that none of them had been diagnosed before the survey. Among those with convulsive epilepsy, the diagnostic gap was 71 % (n = 260/368). Experiencing fewer types of seizure symptoms, non-convulsive seizures, or seizures with subtle features, such as those involving only one body part and those whose first experience of a seizure was recent, were associated with a wider epilepsy diagnostic gap.

Conclusion

There is critically huge diagnostic gap for epilepsy in Nairobi's informal settlements. People with subtle, fewer or less obvious seizure types are more likely to be undiagnosed. These findings highlight the importance of seizure symptom characteristics in understanding patterns of underdiagnosis. Thus, approaches to reducing the diagnostic gap should take into consideration subtle and non-convulsive seizure presentations, such as training on symptom recognition and timely care-seeking.
在癫痫诊断方面存在很大差距,特别是在低收入和中等收入国家。我们使用机器学习模型在肯尼亚内罗毕城市健康和人口监测系统(NUHDSS)中识别与癫痫诊断差距相关的癫痫相关因素,为有效的社区干预提供信息。方法数据来自两阶段的人口普查。在第一阶段,使用标准化问卷对56425名NUHDSS患者进行了可能的惊厥性和非惊厥性癫痫筛查。在ii期,筛选阳性的个体被邀请由神经科医生进行临床评估和诊断确认。我们使用潜在类别分析对症状模式进行分类。我们训练了7个机器学习模型,其中极端梯度增强和随机森林模型在接收者工作特征曲线下的面积最大(98%)。结果528人被诊断为癫痫,其中80% (n = 420)未被诊断。在非惊厥性癫痫患者中,癫痫诊断差距为100% (n = 160/160),这意味着在调查之前没有人被诊断出来。在惊厥癫痫患者中,诊断差距为71% (n = 260/368)。发作症状类型较少、非惊厥性发作或发作具有细微特征,如仅累及一个身体部位和最近才首次发作的患者,与癫痫诊断差距较大相关。结论在内罗毕的非正规住区中,癫痫的诊断差距非常大。有轻微的,较少或不太明显的癫痫发作类型的人更有可能被诊断出来。这些发现强调了癫痫症状特征在理解诊断不足模式中的重要性。因此,减少诊断差距的方法应考虑到细微和非惊厥发作的表现,如培训症状识别和及时寻求护理。
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引用次数: 0
A comparative analysis of social support, risk behaviors, and HIV health service use among adolescent and young males and females in Lusaka, Zambia 赞比亚卢萨卡青少年和年轻男性和女性的社会支持、风险行为和艾滋病毒卫生服务使用情况的比较分析
Pub Date : 2025-12-22 DOI: 10.1016/j.gloepi.2025.100240
Sanjana Batabyal , Ronald Mungoni , Drosin Mulenga , Nachela Chelwa , Michael Mbizvo , Laura Nyblade , Yevgeniya Kaganova , Sonja Hoover , Sujha Subramanian

Background

Human immunodeficiency virus (HIV) remains the leading cause of death in Zambia. While females are disproportionately affected by HIV, males – especially young males – are vulnerable to the disease due to a variety of risk factors. This study aimed to understand what, if any, sex-related differences exist between young females and males on social support, risk behavior, and HIV healthcare utilization issues.

Methods

Baseline survey responses from an implementation trial (NCT03995953) were examined for 863 females and 302 males affected by HIV between ages 15 and 26. We created summary statistics related to peer and familial support, risk factors (i.e., physical safety, economic security, mental health, substance abuse, and sexual behavior), and HIV healthcare utilization. Summary statistics were evaluated for statistical significance through Pearson Chi-Square testing.

Findings

Females and males, regardless of HIV status, have higher average confidence in familial support (67 %) than peer support (40 %). Across HIV status, females and males had similar rates of physical safety risk. Regardless of HIV status, about half the participants reported worrying about running out of food. Substance abuse risk is higher among males; 15 % of males at risk of HIV and 7 % of males living with HIV report drug usage other than alcohol or marijuana compared to just 1 % of all females. Among individuals at risk of HIV, there are differences in rates of HIV testing by sex: 27.7 % among males vs. 6.7 % among females.

Interpretations

While there are some differences, the many similarities between young females and males suggest that joint interventions which incorporate familial support could be beneficial to address shared risk factors. These joint interventions can be supplemented with sex-specific interventions related to substance abuse for males and HIV testing for females.

Funding

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number UH3HD096908. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
人类免疫缺陷病毒(HIV)仍然是赞比亚死亡的主要原因。虽然女性受到艾滋病毒的影响不成比例,但由于各种风险因素,男性——尤其是年轻男性——容易感染这种疾病。本研究旨在了解年轻女性和男性在社会支持、风险行为和HIV保健利用问题上存在的性别相关差异。方法对一项实施试验(NCT03995953)的基线调查结果进行检查,其中863名女性和302名男性在15至26岁之间感染艾滋病毒。我们创建了与同伴和家庭支持、风险因素(即身体安全、经济保障、精神健康、药物滥用和性行为)和艾滋病毒医疗保健利用相关的汇总统计数据。通过Pearson卡方检验评估汇总统计量的统计学显著性。研究结果无论是否感染艾滋病毒,女性和男性对家庭支持的平均信心(67%)高于同伴支持(40%)。在艾滋病毒感染状况中,女性和男性的人身安全风险率相似。不管是否感染艾滋病毒,大约一半的参与者都表示担心食物短缺。男性滥用药物的风险更高;15%有感染艾滋病毒风险的男性和7%感染艾滋病毒的男性报告使用酒精或大麻以外的药物,而在所有女性中,这一比例仅为1%。在有感染艾滋病毒风险的个体中,按性别划分的艾滋病毒检测率存在差异:男性为27.7%,女性为6.7%。解释:虽然存在一些差异,但年轻女性和男性之间的许多相似之处表明,包括家庭支持的联合干预可能有利于解决共同的风险因素。这些联合干预措施可辅以针对男性的药物滥用和针对女性的艾滋病毒检测等针对性别的干预措施。本出版物中报道的研究得到了美国国立卫生研究院尤尼斯·肯尼迪·施莱佛国家儿童健康与人类发展研究所的支持,资助编号为UH3HD096908。内容完全是作者的责任,并不一定代表美国国立卫生研究院的官方观点。
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引用次数: 0
Socioeconomic and regional determinants of optimal antenatal care utilization among women in South and Central Somalia 索马里南部和中部妇女最佳产前保健利用的社会经济和区域决定因素
Pub Date : 2025-12-18 DOI: 10.1016/j.gloepi.2025.100239
Mohamed Abdirahim Omar , Yahye Sheikh Abdulle Hassan , Abdirasak Sharif Ali , Mohamed Mustaf Ahmed

Background

Somalia faces one of the world's highest maternal mortality ratios, and fewer than one in sixteen pregnant women obtain the previously recommended minimum of four antenatal care (ANC) visits. Understanding the drivers of low ANC use is essential for responsive policy. We investigated the prevalence and determinants of optimal ANC use (≥4 visits) among women in South and Central Somalia using nationally representative survey data.

Methods

We conducted a cross-sectional analysis of the 2020 Somali Health and Demographic Survey. The weighted analytic sample comprised 4124 women aged 15–49 years with complete data. Survey-adjusted descriptive statistics characterized ANC use. Bivariate associations and multivariable survey logistic regression identified independent predictors; adjusted odds ratios (aORs) with 95 % confidence intervals (CIs) are reported.

Results

Only 5.7 % of women (95 % CI 4.3–7.6) had four or more ANC visits. After adjustment, secondary education (aOR 2.33, 95 % CI 1.01–5.40) and higher education (aOR 5.36, 95 % CI 1.58–18.15) were associated with optimal ANC. Household wealth showed a graded increase, with the richest quintile having nearly 30 times the odds compared with the poorest (aOR 29.66, 95 % CI 8.51–101.27). Home delivery was associated with lower odds of optimal ANC (aOR 0.29, 95 % CI 0.18–0.47). Regional disparities persisted: women in Bay (aOR 4.07, 95 % CI 1.22–13.60) and Galgaduud (aOR 2.74, 95 % CI 1.13–6.64) had higher odds than those in Mudug.

Conclusion

Optimal ANC coverage in South and Central Somalia remains critically low. Priorities include reducing financial and geographic barriers to care, strengthening facility-based services, and promoting female education to improve maternal and neonatal outcomes.
索马里是世界上孕产妇死亡率最高的国家之一,每16名孕妇中只有不到1名获得了先前建议的至少4次产前保健(ANC)。了解低ANC使用率的驱动因素对于制定响应性政策至关重要。我们使用具有全国代表性的调查数据调查了索马里南部和中部妇女中最佳ANC使用(≥4次就诊)的患病率和决定因素。方法:我们对2020年索马里健康和人口调查进行了横断面分析。加权分析样本包括4124名15-49岁的女性,数据完整。经调查调整的描述性统计描述了ANC的使用。双变量关联和多变量调查逻辑回归确定独立预测因子;校正优势比(aORs)为95%置信区间(ci)。结果只有5.7%的女性(95% CI 4.3-7.6)有4次以上的ANC就诊。调整后,中等教育(aOR 2.33, 95% CI 1.01-5.40)和高等教育(aOR 5.36, 95% CI 1.58-18.15)与最佳ANC相关。家庭财富呈分级增长,最富有的五分之一人群的财富是最贫穷人群的近30倍(比值比29.66,95%可信区间8.51-101.27)。家中分娩与较低的最佳ANC几率相关(aOR 0.29, 95% CI 0.18-0.47)。地区差异仍然存在:Bay (aOR 4.07, 95% CI 1.22-13.60)和galgadudud (aOR 2.74, 95% CI 1.13-6.64)的女性患乳腺癌的几率高于Mudug。索马里南部和中部的最佳ANC覆盖率仍然极低。优先事项包括减少获得护理的资金和地理障碍,加强基于设施的服务,以及促进女性教育以改善孕产妇和新生儿结局。
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引用次数: 0
Undetected circulation of monkeypox virus in Portugal: Evidence for a 50-day gap before first detection 葡萄牙未被发现的猴痘病毒传播:首次发现前50天间隔的证据
Pub Date : 2025-12-15 DOI: 10.1016/j.gloepi.2025.100238
Rita Cordeiro , Fernando da Conceição Batista , Ana Pelerito , Isabel Lopes de Carvalho , Sílvia Lopo , Raquel Neves , Raquel Rocha , Paula Palminha , Maria José Borrego , Maria Sofia Núncio , João Paulo Gomes
As mpox continues to spread globally, proactive monitoring and preparedness are crucial to minimize impact and enhance response strategies. Using a mathematical model combining a negative binomial distribution with Richards' logistic curve, we reconstructed the hidden phase of mpox transmission in Portugal, offering insights into the timing and dynamics of the initial outbreak. The analysis of 950 PCR-positive and 986 negative cases suggested that symptom onset occurred between March 24 and April 2, 2022, with March 27 identified as the most probable date. This study delineates the likely period of silent circulation of MPXV in Portugal, providing a clearer understanding of early outbreak dynamics and surveillance performance. Possible imperfections in early diagnostic testing and limited awareness of mpox may have contributed to delayed recognition of the outbreak. By demonstrating how retrospective mathematical modelling can estimate undetected transmission periods, our findings highlight the value of such approaches in epidemic reconstruction and underscore the importance of strengthening early surveillance systems to detect undiagnosed transmission of mpox in non-endemic countries.
随着麻疹继续在全球蔓延,积极监测和防范对于尽量减少影响和加强应对战略至关重要。利用将负二项分布与Richards logistic曲线相结合的数学模型,我们重建了葡萄牙m痘传播的隐藏阶段,从而深入了解了最初爆发的时间和动态。对950例pcr阳性和986例阴性病例的分析表明,症状发生在2022年3月24日至4月2日之间,3月27日被确定为最有可能的发病日期。本研究描述了MPXV在葡萄牙静默传播的可能时期,为早期疫情动态和监测表现提供了更清晰的认识。早期诊断检测方面可能存在的缺陷和对痘的认识有限,可能导致对疫情的认识延迟。通过展示回顾性数学模型如何能够估计未被发现的传播期,我们的研究结果强调了这种方法在流行病重建中的价值,并强调了加强早期监测系统以在非流行国家发现未被诊断的m痘传播的重要性。
{"title":"Undetected circulation of monkeypox virus in Portugal: Evidence for a 50-day gap before first detection","authors":"Rita Cordeiro ,&nbsp;Fernando da Conceição Batista ,&nbsp;Ana Pelerito ,&nbsp;Isabel Lopes de Carvalho ,&nbsp;Sílvia Lopo ,&nbsp;Raquel Neves ,&nbsp;Raquel Rocha ,&nbsp;Paula Palminha ,&nbsp;Maria José Borrego ,&nbsp;Maria Sofia Núncio ,&nbsp;João Paulo Gomes","doi":"10.1016/j.gloepi.2025.100238","DOIUrl":"10.1016/j.gloepi.2025.100238","url":null,"abstract":"<div><div>As mpox continues to spread globally, proactive monitoring and preparedness are crucial to minimize impact and enhance response strategies. Using a mathematical model combining a negative binomial distribution with Richards' logistic curve, we reconstructed the hidden phase of mpox transmission in Portugal, offering insights into the timing and dynamics of the initial outbreak. The analysis of 950 PCR-positive and 986 negative cases suggested that symptom onset occurred between March 24 and April 2, 2022, with March 27 identified as the most probable date. This study delineates the likely period of silent circulation of MPXV in Portugal, providing a clearer understanding of early outbreak dynamics and surveillance performance. Possible imperfections in early diagnostic testing and limited awareness of mpox may have contributed to delayed recognition of the outbreak. By demonstrating how retrospective mathematical modelling can estimate undetected transmission periods, our findings highlight the value of such approaches in epidemic reconstruction and underscore the importance of strengthening early surveillance systems to detect undiagnosed transmission of mpox in non-endemic countries.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"11 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling hidden heterogeneity and inequalities in the continuum of care for reproductive, maternal, and child health services in sub-Saharan Africa: A multilevel latent class analysis approach 揭示撒哈拉以南非洲生殖、孕产妇和儿童健康服务连续护理中隐藏的异质性和不平等:一种多层次潜在类别分析方法
Pub Date : 2025-12-11 DOI: 10.1016/j.gloepi.2025.100237
Abebew Aklog Asmare , Awoke Seyoum Tegegne , Denekew Bitew Belay
Improving reproductive, maternal, newborn, and child health (RMNCH) services is vital for achieving the Sustainable Development Goals (SDGs) for maternal and child survival. This study utilized multilevel latent class analysis (MLCA) on Demographic and Health Surveys (DHS) data from 29 sub-Saharan African (sSA) countries to identify RMNCH service utilization patterns, examine covariate effects, and assess coverage inequalities. Secondary data from the most recent DHS conducted in 29 sSA countries from 2015 to 2024 were used. MLCA was performed on 12 RMNCH service indicators to account for the hierarchical structure of the data. Summary inequality indicators were used to assess differences in posterior class membership for lower-level classes across wealth quintiles, maternal education, maternal occupation, and place of residence. Women's RMNCH service utilization was divided into two categories: optimal and suboptimal users, and two higher-level categories: high and low coverage. Higher maternal education, household wealth, media access, and early antenatal care were related to a higher likelihood of being in the optimal utilizer class. In contrast, rural location and a longer distance to health services were associated with a lower likelihood. Inequality indices revealed significant differences among optimal utilizers, particularly in terms of mother education and household wealth. Targeted interventions are urgently required to promote RMNCH service utilization in sSA by addressing persistent socioeconomic disparities, particularly among women with no education, lower incomes, and low access to health care.
改善生殖、孕产妇、新生儿和儿童健康服务对于实现关于孕产妇和儿童生存的可持续发展目标至关重要。本研究利用来自29个撒哈拉以南非洲(sSA)国家的人口与健康调查(DHS)数据的多水平潜在类分析(MLCA)来确定RMNCH服务利用模式,检查协变量效应,并评估覆盖不平等。使用了2015年至2024年在29个sSA国家进行的最新DHS的次要数据。为了解释数据的层次结构,对12个RMNCH服务指标进行了MLCA。摘要不平等指标用于评估不同财富五分位数、母亲教育、母亲职业和居住地的下层阶级后验阶级成员的差异。将妇女RMNCH服务利用率分为最优用户和次优用户两类,以及高覆盖率和低覆盖率两个更高层次的类别。较高的母亲教育、家庭财富、媒体访问和早期产前保健与进入最佳利用阶层的可能性较高有关。相比之下,农村地区和较远的医疗服务与较低的可能性相关。不平等指数揭示了最佳利用者之间的显著差异,特别是在母亲教育和家庭财富方面。迫切需要有针对性的干预措施,通过解决持续存在的社会经济差距,特别是未受教育、收入较低和获得医疗保健机会较少的妇女之间的差距,促进社会保障区内妇幼保健服务的利用。
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引用次数: 0
AlzStack: Forecasting early-onset Alzheimer's with an explainable AI system using multiple data balancing techniques AlzStack:使用多种数据平衡技术,通过可解释的人工智能系统预测早发性阿尔茨海默病
Pub Date : 2025-12-07 DOI: 10.1016/j.gloepi.2025.100235
Venkata Aditi Modali , Manohar Pavanya , R. Vijaya Arjunan , D. Cenitta , Niranjana Sampathila , Radhika Kamath , Krishnaraj Chadaga
Alzheimer's disease (AD) is a degenerative neurological disease that progresses over time, making early detection crucial for effective intervention and better patient prognosis. Traditional diagnostic methods such as cognitive assessments, neuroimaging, and biomarker analysis can be time-consuming, costly, and inconsistent. We introduce AlzStack, a soft voting ensemble model to classify AD from a richly detailed dataset containing 2149 patients across demographic, medical, lifestyle, and cognitive variables. To resolve class imbalance, we implemented a pipeline 5-fold cross-validation, randomized search for hyper parameter tuning and advanced resampling methods such as SMOTE (Synthetic Minority Oversampling Technique), ADASYN, BorderlineSMOTE, and SVMSMOTE. Soft Vote Classifier surpassed both stacking ensembles and hard voting with an AUC value of 94.27 %, accuracy of 93.26 %, precision of 89.17 %, a recall of 92.11 %, and F1-score value of 90.61 %.A secondary experiment with only resampling methods applied to data to all base models served as a baseline for comparison confirming the superior performance of cross-validation AlzStack configuration. To improve interpretability, we utilized a wide range of Explainable Artificial Intelligence (XAI methods) and these approaches yielded global and local explanations about model behavior, emphasizing key features like MMSE scores, functional measures, and behavioral markers. Combining robust predictive performance with explainable decision-making makes AlzStack is a healthcare decision-support algorithm for the early detection of AD.
阿尔茨海默病(AD)是一种随时间进展的退行性神经系统疾病,因此早期发现对于有效干预和改善患者预后至关重要。传统的诊断方法,如认知评估、神经成像和生物标志物分析,可能耗时、昂贵且不一致。我们介绍了AlzStack,这是一个软投票集成模型,用于从包含2149名患者的数据集中对AD进行分类,包括人口统计、医疗、生活方式和认知变量。为了解决类不平衡问题,我们实现了管道5倍交叉验证,随机搜索超参数调整和高级重采样方法,如SMOTE(合成少数过采样技术),ADASYN, BorderlineSMOTE和SVMSMOTE。软投票分类器的AUC值为94.27%,准确率为93.26%,准确率为89.17%,召回率为92.11%,f1得分值为90.61%,超过了堆叠集成和硬投票。通过对所有基础模型的数据只采用重采样方法进行二次实验,作为比较基线,确认交叉验证AlzStack配置的优越性能。为了提高可解释性,我们使用了广泛的可解释人工智能(XAI方法),这些方法产生了关于模型行为的全局和局部解释,强调了MMSE分数、功能测量和行为标记等关键特征。将稳健的预测性能与可解释的决策相结合,使AlzStack成为一种用于早期发现AD的医疗保健决策支持算法。
{"title":"AlzStack: Forecasting early-onset Alzheimer's with an explainable AI system using multiple data balancing techniques","authors":"Venkata Aditi Modali ,&nbsp;Manohar Pavanya ,&nbsp;R. Vijaya Arjunan ,&nbsp;D. Cenitta ,&nbsp;Niranjana Sampathila ,&nbsp;Radhika Kamath ,&nbsp;Krishnaraj Chadaga","doi":"10.1016/j.gloepi.2025.100235","DOIUrl":"10.1016/j.gloepi.2025.100235","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a degenerative neurological disease that progresses over time, making early detection crucial for effective intervention and better patient prognosis. Traditional diagnostic methods such as cognitive assessments, neuroimaging, and biomarker analysis can be time-consuming, costly, and inconsistent. We introduce AlzStack, a soft voting ensemble model to classify AD from a richly detailed dataset containing 2149 patients across demographic, medical, lifestyle, and cognitive variables. To resolve class imbalance, we implemented a pipeline 5-fold cross-validation, randomized search for hyper parameter tuning and advanced resampling methods such as SMOTE (Synthetic Minority Oversampling Technique), ADASYN, BorderlineSMOTE, and SVMSMOTE. Soft Vote Classifier surpassed both stacking ensembles and hard voting with an AUC value of 94.27 %, accuracy of 93.26 %, precision of 89.17 %, a recall of 92.11 %, and F1-score value of 90.61 %.A secondary experiment with only resampling methods applied to data to all base models served as a baseline for comparison confirming the superior performance of cross-validation AlzStack configuration. To improve interpretability, we utilized a wide range of Explainable Artificial Intelligence (XAI methods) and these approaches yielded global and local explanations about model behavior, emphasizing key features like MMSE scores, functional measures, and behavioral markers. Combining robust predictive performance with explainable decision-making makes AlzStack is a healthcare decision-support algorithm for the early detection of AD.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"11 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of alcohol use and alcohol use disorders among the population of Buea, south west region, Cameroon: A survey study 喀麦隆西南地区Buea人口中酒精使用和酒精使用障碍的流行病学:一项调查研究
Pub Date : 2025-12-03 DOI: 10.1016/j.gloepi.2025.100236
Nadège Emégam Kouémou, Ven-Laura Atem Yega, Franklin Mbeboh Savo, Ndzweng Linda Tamanji

Background

Alcohol consumption worldwide is associated with a range of health and societal problems. Epidemiology data are valuable tools for predicting the outcome of a given behaviour on the general population's health. This study aimed to evaluate the patterns of alcohol consumption among Buea inhabitants.

Material and methods

This cross-sectional study involves 422 participants (244 men and 178 women) aged 15 years and above who have been residents of the Buea municipality for more than a year. This study was conducted from March to May 2019 using a semi-structured questionnaire. The questionnaire included socio-demographic information and the 10 items of the Alcohol Use Disorder Identification Test (AUDIT).

Results

The results obtained showed that many of the alcohol misusers were men. 34.6 % of the participants indicated drinking above the recommended levels. 93.8 % of the respondents admitted to consuming alcohol in the company of others, mostly in bars. Beer was the leading alcoholic beverage consumed in Buea. Alcohol intake for pleasure and to relieve stress were among the leading causes of alcohol drinking in the study population. The vast majority of participants reported misbehavior after alcohol intake. The number of women with AUDIT C score greater than 5 was also significant. Aggressivity, memory loss, and falls after drinking were also recorded in the study population.

Conclusion

The alcohol consumption patterns in Buea are associated with many behavioral misconducts. Therefore, there is a need for community education to curve the incidence of neurological diseases and alcohol addiction behaviour in the Buea municipality.
世界范围内的酒精消费与一系列健康和社会问题有关。流行病学数据是预测特定行为对一般人群健康影响的宝贵工具。本研究旨在评估布埃亚居民的酒精消费模式。材料和方法这项横断面研究涉及422名参与者(244名男性和178名女性),年龄在15岁及以上,在布埃亚市居住超过一年。本研究于2019年3月至5月进行,采用半结构化问卷。问卷内容包括社会人口学信息和酒精使用障碍鉴定测试(AUDIT)的10项内容。结果结果表明,酗酒者以男性居多。34.6%的参与者表示饮酒量超过了建议水平。93.8%的受访者承认曾在他人陪同下饮酒,主要是在酒吧。啤酒是Buea消费的主要酒精饮料。在研究人群中,为娱乐和缓解压力而饮酒是饮酒的主要原因。绝大多数参与者报告了饮酒后的不良行为。审计C得分大于5的女性人数也很显著。在研究人群中,攻击性、记忆力减退和饮酒后跌倒也有记录。结论Buea地区的酒精消费模式与许多不良行为有关。因此,有必要进行社区教育,使布埃亚市的神经系统疾病和酒精成瘾行为的发病率曲线化。
{"title":"Epidemiology of alcohol use and alcohol use disorders among the population of Buea, south west region, Cameroon: A survey study","authors":"Nadège Emégam Kouémou,&nbsp;Ven-Laura Atem Yega,&nbsp;Franklin Mbeboh Savo,&nbsp;Ndzweng Linda Tamanji","doi":"10.1016/j.gloepi.2025.100236","DOIUrl":"10.1016/j.gloepi.2025.100236","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol consumption worldwide is associated with a range of health and societal problems. Epidemiology data are valuable tools for predicting the outcome of a given behaviour on the general population's health. This study aimed to evaluate the patterns of alcohol consumption among Buea inhabitants.</div></div><div><h3>Material and methods</h3><div>This cross-sectional study involves 422 participants (244 men and 178 women) aged 15 years and above who have been residents of the Buea municipality for more than a year. This study was conducted from March to May 2019 using a semi-structured questionnaire. The questionnaire included socio-demographic information and the 10 items of the Alcohol Use Disorder Identification Test (AUDIT).</div></div><div><h3>Results</h3><div>The results obtained showed that many of the alcohol misusers were men. 34.6 % of the participants indicated drinking above the recommended levels. 93.8 % of the respondents admitted to consuming alcohol in the company of others, mostly in bars. Beer was the leading alcoholic beverage consumed in Buea. Alcohol intake for pleasure and to relieve stress were among the leading causes of alcohol drinking in the study population. The vast majority of participants reported misbehavior after alcohol intake. The number of women with AUDIT C score greater than 5 was also significant. Aggressivity, memory loss, and falls after drinking were also recorded in the study population.</div></div><div><h3>Conclusion</h3><div>The alcohol consumption patterns in Buea are associated with many behavioral misconducts. Therefore, there is a need for community education to curve the incidence of neurological diseases and alcohol addiction behaviour in the Buea municipality.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"11 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to <[9 (2025), 100185]> 应改正的错误,
Pub Date : 2025-12-01 DOI: 10.1016/j.gloepi.2025.100215
Marwan Shalabi , Salam Ghanem , Iyad Al-Ammouri , Amirah Daher , Enas Al-zayadneh , Alaa Alsmadi , Mais Ayyoub , Samah Abughanam , Mariam Jabr , Montaha AL-Iede
{"title":"Corrigendum to <Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19, Clinical Characteristics: A Multi-Center Observational Study from Jordan> <[9 (2025), 100185]>","authors":"Marwan Shalabi ,&nbsp;Salam Ghanem ,&nbsp;Iyad Al-Ammouri ,&nbsp;Amirah Daher ,&nbsp;Enas Al-zayadneh ,&nbsp;Alaa Alsmadi ,&nbsp;Mais Ayyoub ,&nbsp;Samah Abughanam ,&nbsp;Mariam Jabr ,&nbsp;Montaha AL-Iede","doi":"10.1016/j.gloepi.2025.100215","DOIUrl":"10.1016/j.gloepi.2025.100215","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to ‘Mathematical modelling and time series clustering of Mpox outbreak: A comparative study of the top 10 affected countries and implications for future outbreak management’ [Global Epidemiology 10 (2025) 100214] “ m痘暴发的数学建模和时间序列聚类:十大受影响国家的比较研究及其对未来暴发管理的影响”的勘误表[全球流行病学10 (2025)100214]
Pub Date : 2025-12-01 DOI: 10.1016/j.gloepi.2025.100216
Mark-Daniels Tamakloe , Ametus Kuuwill , Ibrahim Osumanu , Helina Siripi
{"title":"Corrigendum to ‘Mathematical modelling and time series clustering of Mpox outbreak: A comparative study of the top 10 affected countries and implications for future outbreak management’ [Global Epidemiology 10 (2025) 100214]","authors":"Mark-Daniels Tamakloe ,&nbsp;Ametus Kuuwill ,&nbsp;Ibrahim Osumanu ,&nbsp;Helina Siripi","doi":"10.1016/j.gloepi.2025.100216","DOIUrl":"10.1016/j.gloepi.2025.100216","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical cancer burden in India: A descriptive epidemiological study and policy insights 印度子宫颈癌负担:描述性流行病学研究和政策见解
Pub Date : 2025-12-01 DOI: 10.1016/j.gloepi.2025.100233
Khushwant Singh , Ashoo Grover , Kavitha Dhanasekaran

Background

Cervical cancer remains a major global health issue, particularly in low- and middle-income countries (LMICs). Although human papillomavirus (HPV) vaccination and screening are proven preventive strategies, LMICs, including India, face significant implementation challenges.

Methods

This observational, descriptive epidemiological study analyzes cervical cancer burden across WHO regions sourcing data from GLOBOCAN 2022, GBD, and GHO. India-specific state-level analysis was conducted using GBD data. Joinpoint regression assessed death trends, and a comparative analysis examined the impact of India's 2016 national cervical cancer screening and management policies.

Findings

The Southeast Asia Region (SEARO) accounts for the second-highest cervical cancer incident (new cases) and death rate among WHO regions, with India contributing over 65 % of the burden. National screening coverage remains alarmingly low, with only 1.9 % of women aged 30–49 undergoing screening, far below developed nations. Despite the adoption of Visual Inspection with Acetic Acid (VIA) as primary screening method in 2016, India's cervical cancer death rates have continued to rise, increasing from 6.06 to 6.78 per 100,000 women (2012–2016) to 6.82–6.91 (2016–2019). However, death annual percentage change declined from 3.84 % (2012–2015) to 0.46 % (2016–2019), indicates slowdown in death acceleration but not a reversal.

Conclusion

India's burden remains high due to low screening coverage, reliance on subjective screening test, and limited HPV vaccination. While many countries like Australia and Bhutan have successfully reduced incidence and death through HPV-based screening and vaccination, India's slow progress underscores the urgent need for policy shifts towards HPV-DNA testing with self-sampling option and national HPV-vaccination programs implementation to curb cervical cancer burden effectively.
宫颈癌仍然是一个主要的全球健康问题,特别是在低收入和中等收入国家(LMICs)。虽然人乳头瘤病毒(HPV)疫苗接种和筛查是经证实的预防战略,但包括印度在内的中低收入国家在实施方面面临重大挑战。这项观察性、描述性流行病学研究分析了世卫组织各区域的宫颈癌负担,数据来自GLOBOCAN 2022、GBD和GHO。使用GBD数据进行了印度特定的邦级分析。联合点回归评估了死亡趋势,比较分析检查了印度2016年国家宫颈癌筛查和管理政策的影响。东南亚区域是世卫组织区域中宫颈癌发病率(新发病例)和死亡率第二高的区域,其中印度占负担的65%以上。全国筛查覆盖率仍然低得惊人,只有1.9%的30-49岁妇女接受筛查,远低于发达国家。尽管2016年采用醋酸目视检查(VIA)作为主要筛查方法,但印度的宫颈癌死亡率仍在继续上升,从每10万名妇女6.06至6.78人(2012-2016年)增加到6.82至6.91人(2016 - 2019年)。然而,死亡年百分比变化从3.84%(2012-2015年)下降到0.46%(2016-2019年),表明死亡加速放缓,但并未逆转。结论由于筛查覆盖率低、依赖主观筛查试验和HPV疫苗接种有限,印度的负担仍然很高。虽然澳大利亚和不丹等许多国家通过基于hpv的筛查和疫苗接种成功地降低了发病率和死亡率,但印度的缓慢进展强调了迫切需要将政策转向带有自采样选项的HPV-DNA检测,并实施国家hpv疫苗接种规划,以有效遏制宫颈癌负担。
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Global Epidemiology
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