首页 > 最新文献

Global Epidemiology最新文献

英文 中文
Strategies to reduce hyponatraemia risk in desmopressin ODT therapy 去氨加压素ODT治疗中降低低钠血症风险的策略
Pub Date : 2025-12-01 DOI: 10.1016/j.gloepi.2025.100234
Philippe Pinton
{"title":"Strategies to reduce hyponatraemia risk in desmopressin ODT therapy","authors":"Philippe Pinton","doi":"10.1016/j.gloepi.2025.100234","DOIUrl":"10.1016/j.gloepi.2025.100234","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical activity patterns and environmental influences: Findings from the Kuwait diabetes epidemiology program 体育活动模式和环境影响:来自科威特糖尿病流行病学项目的发现
Pub Date : 2025-11-12 DOI: 10.1016/j.gloepi.2025.100232
Victor M. Oguoma , Mark Daniel , Ralf-D Schroers , Mohamed Abu-Farha , Faisal H. Al-Refaei , Fahd Al-Mulla , Neil T. Coffee , Saad Alsharrah

Background

Insufficient physical activity (PA) is the fourth leading risk factor for cardiometabolic disease. This study assessed in Kuwait adults the spatial clustering of PA; relationships between PA, climatic factors and built environmental (BE) indicators; and ethnic group differences in PA.

Methods

A population-based cross-sectional study was conducted from 2011 to 2014 targeting adults in Kuwait ≥18 years old, using the World Health Organisation (WHO) Global Physical Activity Questionnaire (GPAQ) to assess five domains of physical activity. 2530 participants were classified as physically active or not physically active based on accruing at least 600 MET (min/week). Objectively measured residential-area BE indicators were extracted using the street address location of study participants. Climatic variables expressed as monthly aggregates were acquired from Kuwait's climate stations. Random effects logit analysis was used to assess the relationships between PA, climatic and BE variables.

Results

The proportion of physically active respondents was 51.9 % (95 % CI: 49.9, 53.8 %). Insufficient PA was greater in women than men. Suburb-level PA ranged from 21.4 % to 81.9 %. Covariate-adjusted analyses of PA revealed a weak positive association between average temperature aOR = 1.03 (95 %CI: 1.00, 1.06), open space sports ground with synthetic grass (300 m) aOR = 1.28 (95 %CI: 0.88, 1.86), and weighted area road density (100 m) aOR = 1.06 (95 %CI: 0.96, 1.17). A lower odds of PA was apparent for respondents who were currently married (vs never married) aOR = 0.68 (95 %CI: 0.46, 0.99), and for women (vs men) aOR = 0.57 (95 %CI: 0.46, 0.72). A greater odds of PA was apparent for the South/Southeast Asian relative to Arab ethnic group aOR = 1.32 (95 %CI: 1.04, 1.67).

Conclusion

This study indicates that half the population in Kuwait did not meet the WHO recommended minimum PA level of at least 600 MET (min/week). Efforts to promote PA in Kuwait should consider addressing gender and ethnic disparities, local environmental factors, and demographic influences such as marital status.
背景:缺乏足够的身体活动(PA)是导致心脏代谢疾病的第四大危险因素。本研究评估了科威特成人PA的空间聚类;气候因子与建筑环境(BE)指标之间的关系以及族群差异。方法采用世界卫生组织(WHO)全球身体活动问卷(GPAQ),于2011年至2014年对科威特≥18岁的成年人进行了一项基于人群的横断面研究,评估了5个身体活动领域。2530名参与者根据累积至少600 MET (min/week)将其分为运动或不运动两组。使用研究参与者的街道地址位置提取客观测量的居住区BE指标。以月总量表示的气候变量是从科威特的气候站获得的。随机效应logit分析评估了PA、气候和BE变量之间的关系。结果参与体育锻炼的受访者比例为51.9% (95% CI: 49.9, 53.8%)。女性比男性更容易出现PA不足。郊区水平的PA从21.4%到81.9%不等。协变量校正分析显示,平均气温aOR = 1.03 (95% CI: 1.00, 1.06)、室外人造草坪运动场(300 m) aOR = 1.28 (95% CI: 0.88, 1.86)、加权面积道路密度(100 m) aOR = 1.06 (95% CI: 0.96, 1.17)呈弱正相关。目前已婚(与从未结婚)的受访者患PA的几率较低,aOR = 0.68 (95% CI: 0.46, 0.99),女性(与男性)aOR = 0.57 (95% CI: 0.46, 0.72)。南亚/东南亚人患前列腺癌的几率明显高于阿拉伯人(or = 1.32) (95% CI: 1.04, 1.67)。该研究表明,科威特有一半的人口没有达到WHO推荐的最低PA水平至少600 MET(分钟/周)。在科威特促进PA的努力应考虑解决性别和种族差异、当地环境因素以及婚姻状况等人口影响。
{"title":"Physical activity patterns and environmental influences: Findings from the Kuwait diabetes epidemiology program","authors":"Victor M. Oguoma ,&nbsp;Mark Daniel ,&nbsp;Ralf-D Schroers ,&nbsp;Mohamed Abu-Farha ,&nbsp;Faisal H. Al-Refaei ,&nbsp;Fahd Al-Mulla ,&nbsp;Neil T. Coffee ,&nbsp;Saad Alsharrah","doi":"10.1016/j.gloepi.2025.100232","DOIUrl":"10.1016/j.gloepi.2025.100232","url":null,"abstract":"<div><h3>Background</h3><div>Insufficient physical activity (PA) is the fourth leading risk factor for cardiometabolic disease. This study assessed in Kuwait adults the spatial clustering of PA; relationships between PA, climatic factors and built environmental (BE) indicators; and ethnic group differences in PA.</div></div><div><h3>Methods</h3><div>A population-based cross-sectional study was conducted from 2011 to 2014 targeting adults in Kuwait ≥18 years old, using the World Health Organisation (WHO) Global Physical Activity Questionnaire (GPAQ) to assess five domains of physical activity. 2530 participants were classified as physically active or not physically active based on accruing at least 600 MET (min/week). Objectively measured residential-area BE indicators were extracted using the street address location of study participants. Climatic variables expressed as monthly aggregates were acquired from Kuwait's climate stations. Random effects logit analysis was used to assess the relationships between PA, climatic and BE variables.</div></div><div><h3>Results</h3><div>The proportion of physically active respondents was 51.9 % (95 % CI: 49.9, 53.8 %). Insufficient PA was greater in women than men. Suburb-level PA ranged from 21.4 % to 81.9 %. Covariate-adjusted analyses of PA revealed a weak positive association between average temperature aOR = 1.03 (95 %CI: 1.00, 1.06), open space sports ground with synthetic grass (300 m) aOR = 1.28 (95 %CI: 0.88, 1.86), and weighted area road density (100 m) aOR = 1.06 (95 %CI: 0.96, 1.17). A lower odds of PA was apparent for respondents who were currently married (vs never married) aOR = 0.68 (95 %CI: 0.46, 0.99), and for women (vs men) aOR = 0.57 (95 %CI: 0.46, 0.72). A greater odds of PA was apparent for the South/Southeast Asian relative to Arab ethnic group aOR = 1.32 (95 %CI: 1.04, 1.67).</div></div><div><h3>Conclusion</h3><div>This study indicates that half the population in Kuwait did not meet the WHO recommended minimum PA level of at least 600 MET (min/week). Efforts to promote PA in Kuwait should consider addressing gender and ethnic disparities, local environmental factors, and demographic influences such as marital status.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and temporal distribution of SARS-CoV-2 circulating in the municipal wastewaters of the Buffalo City region, Eastern Cape, South Africa 南非东开普省水牛城地区城市废水中循环的SARS-CoV-2的发病率和时间分布
Pub Date : 2025-11-11 DOI: 10.1016/j.gloepi.2025.100229
Okuhle Mayoyo , Luyanda Msolo , Kingsley E. Ebomah , Nolonwabo Nontongana , Anthony I. Okoh

Background

The global health catastrophe of the Coronavirus Disease 2019 (COVID-19) resulted from the emergence and proliferation of a Betacoronavirus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Since the unprecedented pandemic, over 6 million fatalities associated with COVID-19 have been observed on a global scale, and the world economy has taken a toll. The virus is discharged into the wastewater milieu, posing significant environmental and public health concerns. Hence, this investigation sought to explicate the incidence of SARS-CoV-2 RNA in the municipal wastewater of Buffalo City Metropolitan Municipality (BCMM).

Methods

Raw wastewater samples were obtained from inlets of various municipal wastewater treatment plants (WWTPs) in BCMM for a 46-week surveillance period. Commercial kits were utilized to extract viral Ribonucleic Acid (RNA) from 486 wastewater samples following the standard operating protocol. Subsequently, the Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) was employed to profile the pervasiveness of SARS-CoV-2 RNA over the surveillance period.

Results and conclusion

351 (72 %) possessed the nucleocapsid protein gene, signifying SARS-CoV-2 RNA in the municipal wastewater. A time series analysis revealed relatively higher SARS-CoV-2 RNA counts in autumn (2022). A moderate correlation (r = 0.43) was observed between the SARS-CoV-2 RNA and the estimated number of infected individuals. Nonetheless, the pervasiveness of SARS-CoV-2 in this environment is of critical public health significance, offering a valuable indicator of community-level viral spread. The present study's findings substantiate our understanding that wastewater possesses pathogens of interest, emphasize the importance of monitoring wastewater.
2019冠状病毒病(COVID-19)的全球卫生灾难是由一种冠状病毒——严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的出现和增殖引起的。自这场前所未有的大流行以来,全球已有600多万人因COVID-19死亡,世界经济受到损害。病毒被排放到废水环境中,造成严重的环境和公共卫生问题。因此,本研究旨在阐明布法罗市(BCMM)城市废水中SARS-CoV-2 RNA的发生率。方法从北京市各城市污水处理厂进水口抽取原水样本,进行为期46周的监测。采用商用试剂盒按照标准操作规程从486份废水样品中提取病毒核糖核酸(RNA)。随后,采用定量逆转录聚合酶链反应(RT-qPCR)分析了SARS-CoV-2 RNA在监测期间的广泛性。结果与结论351例(72%)城市污水中含有核衣壳蛋白基因,表示SARS-CoV-2 RNA。时间序列分析显示,秋季(2022年)SARS-CoV-2 RNA计数相对较高。在SARS-CoV-2 RNA与估计感染人数之间观察到中度相关性(r = 0.43)。尽管如此,SARS-CoV-2在这种环境中的普遍存在具有重要的公共卫生意义,为社区层面的病毒传播提供了有价值的指标。本研究的发现证实了我们对废水具有感兴趣的病原体的认识,强调了监测废水的重要性。
{"title":"Incidence and temporal distribution of SARS-CoV-2 circulating in the municipal wastewaters of the Buffalo City region, Eastern Cape, South Africa","authors":"Okuhle Mayoyo ,&nbsp;Luyanda Msolo ,&nbsp;Kingsley E. Ebomah ,&nbsp;Nolonwabo Nontongana ,&nbsp;Anthony I. Okoh","doi":"10.1016/j.gloepi.2025.100229","DOIUrl":"10.1016/j.gloepi.2025.100229","url":null,"abstract":"<div><h3>Background</h3><div>The global health catastrophe of the Coronavirus Disease 2019 (COVID-19) resulted from the emergence and proliferation of a <em>Betacoronavirus</em>, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Since the unprecedented pandemic, over 6 million fatalities associated with COVID-19 have been observed on a global scale, and the world economy has taken a toll. The virus is discharged into the wastewater milieu, posing significant environmental and public health concerns. Hence, this investigation sought to explicate the incidence of SARS-CoV-2 RNA in the municipal wastewater of Buffalo City Metropolitan Municipality (BCMM).</div></div><div><h3>Methods</h3><div>Raw wastewater samples were obtained from inlets of various municipal wastewater treatment plants (WWTPs) in BCMM for a 46-week surveillance period. Commercial kits were utilized to extract viral Ribonucleic Acid (RNA) from 486 wastewater samples following the standard operating protocol. Subsequently, the Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) was employed to profile the pervasiveness of SARS-CoV-2 RNA over the surveillance period.</div></div><div><h3>Results and conclusion</h3><div>351 (72 %) possessed the nucleocapsid protein gene, signifying SARS-CoV-2 RNA in the municipal wastewater. A time series analysis revealed relatively higher SARS-CoV-2 RNA counts in autumn (2022). A moderate correlation (<em>r</em> = 0.43) was observed between the SARS-CoV-2 RNA and the estimated number of infected individuals. Nonetheless, the pervasiveness of SARS-CoV-2 in this environment is of critical public health significance, offering a valuable indicator of community-level viral spread. The present study's findings substantiate our understanding that wastewater possesses pathogens of interest, emphasize the importance of monitoring wastewater.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on explainable artificial intelligence for predicting dengue outbreaks in Bangladesh 对可解释人工智能预测孟加拉国登革热疫情的思考
Pub Date : 2025-11-08 DOI: 10.1016/j.gloepi.2025.100230
Md. Siddikur Rahman, Md. Abu Bokkor Shiddik
Explainable artificial intelligence for predicting dengue outbreaks in Bangladesh using eco-climatic triggers,” presents an advance method on artificial intelligence (AI) in the integration of data science and epidemiology combining with machine learning (ML) techniques. We reflect here on XAI's vast implication in public health research. Its potential to inform climate sensitive diseases prediction in low level income settings. Dengue is one of the fastest growing public health challenge in densely populated and climate-sensitive regions like Bangladesh. We developed a novel framework on this study that combines predictive accuracy with interpretability and expandability against this fast growing health problem through XAI. It enables the actionable insights for early warning systems (EWS) and disease prevention.
利用生态气候触发器预测孟加拉国登革热疫情的可解释人工智能,“提出了一种先进的人工智能(AI)方法,将数据科学和流行病学与机器学习(ML)技术相结合。我们在此反思XAI在公共卫生研究中的巨大影响。它有可能为低收入环境中气候敏感疾病的预测提供信息。登革热是孟加拉国等人口稠密和气候敏感地区增长最快的公共卫生挑战之一。我们在这项研究中开发了一个新的框架,通过XAI将预测准确性与可解释性和可扩展性相结合,以应对这一快速增长的健康问题。它为早期预警系统(EWS)和疾病预防提供了可行的见解。
{"title":"Reflections on explainable artificial intelligence for predicting dengue outbreaks in Bangladesh","authors":"Md. Siddikur Rahman,&nbsp;Md. Abu Bokkor Shiddik","doi":"10.1016/j.gloepi.2025.100230","DOIUrl":"10.1016/j.gloepi.2025.100230","url":null,"abstract":"<div><div>Explainable artificial intelligence for predicting dengue outbreaks in Bangladesh using eco-climatic triggers,” presents an advance method on artificial intelligence (AI) in the integration of data science and epidemiology combining with machine learning (ML) techniques. We reflect here on XAI's vast implication in public health research. Its potential to inform climate sensitive diseases prediction in low level income settings. Dengue is one of the fastest growing public health challenge in densely populated and climate-sensitive regions like Bangladesh. We developed a novel framework on this study that combines predictive accuracy with interpretability and expandability against this fast growing health problem through XAI. It enables the actionable insights for early warning systems (EWS) and disease prevention.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on “Explainable artificial intelligence for predicting dengue outbreaks in Bangladesh using eco-climatic triggers” 对“利用生态气候触发因素预测孟加拉国登革热疫情的可解释人工智能”的评论
Pub Date : 2025-11-08 DOI: 10.1016/j.gloepi.2025.100231
Indu Singh , Arvind Kumar , Nivedita Nikhil Desai , Jeffrin Reneus Paul
{"title":"Commentary on “Explainable artificial intelligence for predicting dengue outbreaks in Bangladesh using eco-climatic triggers”","authors":"Indu Singh ,&nbsp;Arvind Kumar ,&nbsp;Nivedita Nikhil Desai ,&nbsp;Jeffrin Reneus Paul","doi":"10.1016/j.gloepi.2025.100231","DOIUrl":"10.1016/j.gloepi.2025.100231","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-life safety assessment of orally disintegrating desmopressin tablet: Incidence of diagnosed hyponatraemia and other events across three European countries 口腔崩解去氨加压素片的现实安全性评估:三个欧洲国家诊断为低钠血症和其他事件的发生率
Pub Date : 2025-10-31 DOI: 10.1016/j.gloepi.2025.100228
Gunnar Johansson , Jonas Reinold , Nelly L. Shapero , Tekla L. Rosell , Leif A. Jørgensen , Niklas Koenen , Christian Frøsig , Michael Falkenberg , Lene Holdrup , Kristian Juul

Objective

This real-life analysis quantifies the incidence rate of diagnosed hyponatraemia in patients treated with a desmopressin Orally Disintegrating Tablet 25–50 μg (ODT) versus patients treated for lower urinary tract symptoms (LUTS) across Sweden, Denmark, and Germany.

Material and methods

Claims data and register data from drug registries, hospital records, laboratories, and intensive care units were accessed from the three countries in this imposed Post-Authorisation Safety Study (PASS). The incidence rates of diagnosed hyponatraemia, mortality, major cardiovascular events (MACE), venous thromboembolism (VTE), and acute exacerbation of congestive heart failure (CHF) were calculated using Poisson regression. A sensitivity analysis and subgroup analyses of older adult patients and patients with contraindications were conducted. The clinicaltrial.gov number is NCT04740645.

Results

In total, 1,099,545 patients were included in Sweden, Denmark, and Germany. Of these 6745 (0.61 %) were ODT-treated patients, and 1,092,800 (99.39 %) were LUTS-treated patients. The incidence rate of diagnosed hyponatraemia, based on ICD-10 codes, was in the range of 9.04–24.15/1000 patient-years in the ODT cohort and 1.39–4.45/1000 patient-years in the LUTS cohort. Laboratory measured clinically significant hyponatraemia had incidence rates of 139.9 and 33.0/1000 patient-years in the ODT and LUTS cohorts, respectively. The incidence rates of mortality, MACE, and VTE were comparable between groups, with variations in subgroups of patients. Due to different baseline characteristics between the countries, a planned meta-analysis could not be performed.

Conclusion

Results from this real-life study does not indicate any added safety concerns related to use of ODT, since increased rate of hyponatraemia is already in the SmPC.
目的:对瑞典、丹麦和德国接受去氨加压素口腔崩解片25-50 μg (ODT)治疗的患者与接受下尿路症状(LUTS)治疗的患者诊断为低钠血症的发生率进行现实分析。材料和方法在本次强制实施的授权后安全性研究(PASS)中,从三个国家的药品登记处、医院记录、实验室和重症监护病房获取了索赔数据和注册数据。使用泊松回归计算诊断出的低钠血症、死亡率、主要心血管事件(MACE)、静脉血栓栓塞(VTE)和充血性心力衰竭急性加重(CHF)的发生率。对老年患者和有禁忌症的患者进行敏感性分析和亚组分析。clinicaltrial.gov网站号码是NCT04740645。结果瑞典、丹麦和德国共纳入1,099,545例患者。其中6745例(0.61%)为odt治疗患者,1,092,800例(99.39%)为luts治疗患者。根据ICD-10编码,诊断为低钠血症的发生率在ODT队列中为9.04-24.15/1000患者-年,在LUTS队列中为1.39-4.45/1000患者-年。实验室测量的临床显著性低钠血症在ODT和LUTS队列中的发病率分别为139.9和30.3 /1000患者-年。死亡率、MACE和静脉血栓栓塞的发生率在两组之间具有可比性,在患者亚组中存在差异。由于各国之间的基线特征不同,无法进行计划的荟萃分析。结论:这项现实生活研究的结果并未表明使用ODT有任何额外的安全性问题,因为低钠血症的发生率已经在SmPC中增加。
{"title":"Real-life safety assessment of orally disintegrating desmopressin tablet: Incidence of diagnosed hyponatraemia and other events across three European countries","authors":"Gunnar Johansson ,&nbsp;Jonas Reinold ,&nbsp;Nelly L. Shapero ,&nbsp;Tekla L. Rosell ,&nbsp;Leif A. Jørgensen ,&nbsp;Niklas Koenen ,&nbsp;Christian Frøsig ,&nbsp;Michael Falkenberg ,&nbsp;Lene Holdrup ,&nbsp;Kristian Juul","doi":"10.1016/j.gloepi.2025.100228","DOIUrl":"10.1016/j.gloepi.2025.100228","url":null,"abstract":"<div><h3>Objective</h3><div>This real-life analysis quantifies the incidence rate of diagnosed hyponatraemia in patients treated with a desmopressin Orally Disintegrating Tablet 25–50 μg (ODT) versus patients treated for lower urinary tract symptoms (LUTS) across Sweden, Denmark, and Germany.</div></div><div><h3>Material and methods</h3><div>Claims data and register data from drug registries, hospital records, laboratories, and intensive care units were accessed from the three countries in this imposed Post-Authorisation Safety Study (PASS). The incidence rates of diagnosed hyponatraemia, mortality, major cardiovascular events (MACE), venous thromboembolism (VTE), and acute exacerbation of congestive heart failure (CHF) were calculated using Poisson regression. A sensitivity analysis and subgroup analyses of older adult patients and patients with contraindications were conducted. The <span><span>clinicaltrial.gov</span><svg><path></path></svg></span> number is <span><span>NCT04740645</span><svg><path></path></svg></span>.</div></div><div><h3>Results</h3><div>In total, 1,099,545 patients were included in Sweden, Denmark, and Germany. Of these 6745 (0.61 %) were ODT-treated patients, and 1,092,800 (99.39 %) were LUTS-treated patients. The incidence rate of diagnosed hyponatraemia, based on ICD-10 codes, was in the range of 9.04–24.15/1000 patient-years in the ODT cohort and 1.39–4.45/1000 patient-years in the LUTS cohort. Laboratory measured clinically significant hyponatraemia had incidence rates of 139.9 and 33.0/1000 patient-years in the ODT and LUTS cohorts, respectively. The incidence rates of mortality, MACE, and VTE were comparable between groups, with variations in subgroups of patients. Due to different baseline characteristics between the countries, a planned meta-analysis could not be performed.</div></div><div><h3>Conclusion</h3><div>Results from this real-life study does not indicate any added safety concerns related to use of ODT, since increased rate of hyponatraemia is already in the SmPC.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors related to sleep quality in the adult population of Shahroud; Comparison of adjusted distributional and multivariable logistic regression analysis 沙赫鲁德地区成人睡眠质量相关因素分析调整分布与多变量logistic回归分析的比较
Pub Date : 2025-10-20 DOI: 10.1016/j.gloepi.2025.100227
Hajar Golbabaei Pasandi , Ahmad Khosravi , Mohammad Hassan Emamian , Seyed Abbas Mousavi , Hassan Hashemi , Akbar Fotouhi

Background

Dichotomizing a continuous outcome, sleep quality score, is associated with loss of information, and bias. Here we compared the performance of dichotomizing sleep quality scores according to cut-point as outcome variable in multivariable logistic regression with using that as continuous outcome in an adjusted distributional method.

Methods

In this study, the data from the second phase of the Shahroud eye cohort study (ShECS) on 4710 adults were used. Sleep quality score using Pittsburg index was normalized using item response theory (IRT) method. Sleep quality score was used as a dichotomized variable in a logistic regression model and as a continuous variable in an adjusted distributional method.

Results

The overall prevalence of poor sleep quality was 44.9 % (95 %CI, 43.4–46.2). In the adjusted distributional model poor sleep quality was associated with female gender (OR = 2.08; 95 %CI: 1.9–2.2), old age (OR = 1.2; 95 %CI: 1.0–1.4), low economic status (OR = 1.3; 95 % CI: 1.1–1.4), Illiteracy (OR = 1.4; 95 %CI: 1.2–1.7), diabetes (OR = 1.1; 95 %CI: 1.0–1.2), hypertension (OR = 1.2; 95 %CI: 1.0–1.3) and tobacco smoking (OR = 1.2; 95 %CI: 1.1–1.4). There was no difference between the size and direction of the observed association between two competing models. The confidence interval of the ORs and the marginal differences in proportions of poor sleep quality for the diabetic and non-diabetic people using the distributional method was more precise (narrower confidence interval) than logistic regression.

Conclusion

Using the adjusted distributional method based on linear regression instead of dichotomizing the continuous outcome in logistic regression leads to narrower and more precise CIs for ORs but size and direction of associations between two models are identical. Comparison between two models showed that statistical performance of two models is equals. In addition to increasing age, women have higher odds of poor sleep quality than men. Some other modifiable predictors such as smoking, diabetes, and hypertension can be investigated to improve sleep quality.
背景:对连续结果,睡眠质量评分进行二分法,与信息丢失和偏差有关。在这里,我们比较了在多变量逻辑回归中以截断点作为结果变量的睡眠质量分数二分法与在调整分布法中使用截断点作为连续结果的睡眠质量分数二分法的表现。方法本研究使用了4710名成人的shahoud眼队列研究(ShECS)的第二阶段数据。匹兹堡睡眠质量评分采用项目反应理论(IRT)进行归一化。睡眠质量评分在logistic回归模型中作为二分类变量,在调整分布法中作为连续变量。结果睡眠质量差的总体患病率为44.9% (95% CI, 43.4-46.2)。在调整后的分布模型中,睡眠质量差与女性(OR = 2.08; 95% CI: 1.9-2.2)、年龄(OR = 1.2; 95% CI: 1.0-1.4)、经济地位低(OR = 1.3; 95% CI: 1.1 - 1.4)、文盲(OR = 1.4; 95% CI: 1.2 - 1.7)、糖尿病(OR = 1.1; 95% CI: 1.0-1.2)、高血压(OR = 1.2; 95% CI: 1.0-1.3)和吸烟(OR = 1.2; 95% CI: 1.1 - 1.4)相关。在两个相互竞争的模型之间观察到的关联的大小和方向没有区别。与logistic回归相比,采用分布法得到的糖尿病和非糖尿病患者睡眠质量差比例的ORs置信区间和边际差异更精确(置信区间更窄)。结论采用基于线性回归的调整分布法,而非logistic回归中对连续结果进行二分类,可使ORs的ci更窄、更精确,但两种模型之间的关联大小和方向相同。两种模型的比较表明,两种模型的统计性能是相等的。除了年龄增长之外,女性睡眠质量差的几率也高于男性。其他一些可改变的预测因素,如吸烟、糖尿病和高血压,可以通过研究来改善睡眠质量。
{"title":"Factors related to sleep quality in the adult population of Shahroud; Comparison of adjusted distributional and multivariable logistic regression analysis","authors":"Hajar Golbabaei Pasandi ,&nbsp;Ahmad Khosravi ,&nbsp;Mohammad Hassan Emamian ,&nbsp;Seyed Abbas Mousavi ,&nbsp;Hassan Hashemi ,&nbsp;Akbar Fotouhi","doi":"10.1016/j.gloepi.2025.100227","DOIUrl":"10.1016/j.gloepi.2025.100227","url":null,"abstract":"<div><h3>Background</h3><div>Dichotomizing a continuous outcome, sleep quality score, is associated with loss of information, and bias. Here we compared the performance of dichotomizing sleep quality scores according to cut-point as outcome variable in multivariable logistic regression with using that as continuous outcome in an adjusted distributional method.</div></div><div><h3>Methods</h3><div>In this study, the data from the second phase of the Shahroud eye cohort study (ShECS) on 4710 adults were used. Sleep quality score using Pittsburg index was normalized using item response theory (IRT) method. Sleep quality score was used as a dichotomized variable in a logistic regression model and as a continuous variable in an adjusted distributional method.</div></div><div><h3>Results</h3><div>The overall prevalence of poor sleep quality was 44.9 % (95 %CI, 43.4–46.2). In the adjusted distributional model poor sleep quality was associated with female gender (OR = 2.08; 95 %CI: 1.9–2.2), old age (OR = 1.2; 95 %CI: 1.0–1.4), low economic status (OR = 1.3; 95 % CI: 1.1–1.4), Illiteracy (OR = 1.4; 95 %CI: 1.2–1.7), diabetes (OR = 1.1; 95 %CI: 1.0–1.2), hypertension (OR = 1.2; 95 %CI: 1.0–1.3) and tobacco smoking (OR = 1.2; 95 %CI: 1.1–1.4). There was no difference between the size and direction of the observed association between two competing models. The confidence interval of the ORs and the marginal differences in proportions of poor sleep quality for the diabetic and non-diabetic people using the distributional method was more precise (narrower confidence interval) than logistic regression.</div></div><div><h3>Conclusion</h3><div>Using the adjusted distributional method based on linear regression instead of dichotomizing the continuous outcome in logistic regression leads to narrower and more precise CIs for ORs but size and direction of associations between two models are identical. Comparison between two models showed that statistical performance of two models is equals. In addition to increasing age, women have higher odds of poor sleep quality than men. Some other modifiable predictors such as smoking, diabetes, and hypertension can be investigated to improve sleep quality.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of multimorbidity among indigenous adults: Insights from a large-scale population survey of 53 different indigenous groups in East India 土著成年人多病的流行病学:来自东印度53个不同土著群体的大规模人口调查的见解
Pub Date : 2025-10-13 DOI: 10.1016/j.gloepi.2025.100226
Kavitha A.K. , Jaya Singh Kshatri , Marjan van den Akker , Mohammad Akhtar Hussain , Haimanti Bhattacharya , Sanghamitra Pati

Purpose

Indigenous populations in India face a growing burden of multimorbidity, yet data on its prevalence and patterns remain scarce. This study estimated the prevalence, determinants, and co-occurrence of multimorbidity among Indigenous adults using data from the Odisha Tribal Family Health Survey (OTFHS).

Methods

The analysis included 19,430 adults (≥18 years) from 9711 households across 14 districts, representing 53 Indigenous groups, including 13 Particularly Vulnerable Tribal Groups (PVTGs). Multimorbidity—defined as having ≥2 chronic conditions—was assessed through self-reports and laboratory results. Prevalence estimates used descriptive statistics; associated factors were identified via ordinal logistic regression, and co-occurrence patterns of chronic conditions were visualized using a matrix-based plot that displays the frequency and overlap of conditions (UpSet plot).

Results

The weighted prevalence of multimorbidity was 21.7 % (95 % CI: 20.5 %, 22.9 %), increasing from 3.8 % in those aged 18–25 to 48.2 % in those 60 and older. Regression analysis showed that older age, male sex, and tobacco and alcohol use were significantly associated with higher odds of multimorbidity. Hypertension was the most prevalent condition, often co-occurring with kidney disease, liver disease, or back pain.

Conclusion

These findings highlight the urgent need for age- and sex-sensitive, integrated health interventions tailored to Indigenous communities.
目的:印度土著人口面临着越来越多的多重疾病负担,但关于其流行程度和模式的数据仍然很少。本研究利用来自奥里萨邦部落家庭健康调查(OTFHS)的数据,估计了土著成年人中多病的患病率、决定因素和共发率。方法对来自14个地区9711个家庭的19430名成年人(≥18岁)进行分析,代表53个土著群体,其中包括13个特别脆弱部落群体(pvtg)。多重发病(定义为具有≥2种慢性疾病)通过自我报告和实验室结果进行评估。流行率估计使用描述性统计;通过有序逻辑回归确定相关因素,并使用基于矩阵的图来可视化慢性疾病的共发生模式,该图显示了疾病的频率和重叠(UpSet图)。结果多病加权患病率为21.7% (95% CI: 20.5%, 22.9%),从18-25岁的3.8%上升到60岁及以上的48.2%。回归分析显示,年龄较大、男性、吸烟和饮酒与多重发病的高几率显著相关。高血压是最常见的疾病,通常与肾脏疾病、肝脏疾病或背痛同时发生。结论这些发现突出了迫切需要针对土著社区的年龄和性别敏感的综合卫生干预措施。
{"title":"Epidemiology of multimorbidity among indigenous adults: Insights from a large-scale population survey of 53 different indigenous groups in East India","authors":"Kavitha A.K. ,&nbsp;Jaya Singh Kshatri ,&nbsp;Marjan van den Akker ,&nbsp;Mohammad Akhtar Hussain ,&nbsp;Haimanti Bhattacharya ,&nbsp;Sanghamitra Pati","doi":"10.1016/j.gloepi.2025.100226","DOIUrl":"10.1016/j.gloepi.2025.100226","url":null,"abstract":"<div><h3>Purpose</h3><div>Indigenous populations in India face a growing burden of multimorbidity, yet data on its prevalence and patterns remain scarce. This study estimated the prevalence, determinants, and co-occurrence of multimorbidity among Indigenous adults using data from the Odisha Tribal Family Health Survey (OTFHS).</div></div><div><h3>Methods</h3><div>The analysis included 19,430 adults (≥18 years) from 9711 households across 14 districts, representing 53 Indigenous groups, including 13 Particularly Vulnerable Tribal Groups (PVTGs). Multimorbidity—defined as having ≥2 chronic conditions—was assessed through self-reports and laboratory results. Prevalence estimates used descriptive statistics; associated factors were identified via ordinal logistic regression, and co-occurrence patterns of chronic conditions were visualized using a matrix-based plot that displays the frequency and overlap of conditions (UpSet plot).</div></div><div><h3>Results</h3><div>The weighted prevalence of multimorbidity was 21.7 % (95 % CI: 20.5 %, 22.9 %), increasing from 3.8 % in those aged 18–25 to 48.2 % in those 60 and older. Regression analysis showed that older age, male sex, and tobacco and alcohol use were significantly associated with higher odds of multimorbidity. Hypertension was the most prevalent condition, often co-occurring with kidney disease, liver disease, or back pain.</div></div><div><h3>Conclusion</h3><div>These findings highlight the urgent need for age- and sex-sensitive, integrated health interventions tailored to Indigenous communities.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of alcohol use in Sri Lanka: Findings of the SLHAS national survey 斯里兰卡酒精使用的流行病学:SLHAS全国调查结果
Pub Date : 2025-10-06 DOI: 10.1016/j.gloepi.2025.100222
Bilesha Perera , Ravindra P. Rannan-Eliya , Nilmini Wijemunige , Sarath Samarage , H.M.M. Herath , Wasantha Jayawardene , Mohammad R. Torabi

Background

Reliable epidemiological evidence of alcohol use in Sri Lanka is limited. This study addressed this gap using nationally representative data.

Methods

Data from a 2018/2019 national study of non-institutionalized adults in Sri Lanka were used. Weighted data were analysed using descriptive and logistic regression techniques.

Results

Among 6473 adults (mean age 43.9 (SD = 16.7); 52.5 % women) surveyed, 53.1 % (95 %CI; 51.9 %, 54.3 %) of men and 2.0 % (95 % CI; 1.9 %, 2.1 %) of women were current (yearly) alcohol users. Per capita consumption of alcohol was 3.12 l for men and 0.028 l for women. Predictors of alcohol use in men included being aged 30–39 years, Sinhalese ethnicity, secondary education, currently married, and being in the middle wealth quintile and in women, being aged 30–39 years, Indian Tamil ethnicity, tertiary education, being a widow or separated, and being in the highest wealth quintile were the significant predictors of current alcohol use. Hazardous drinking (≥21 units per week) was observed only in men: 14.1 %. In men, smoking, elevated blood pressure and low self-rated health were related to higher likelihood of alcohol use. Alcohol use showed protective effects on type 2 diabetes and depression in men.

Conclusions

Prevalence, distribution and associated factors of alcohol use vary by demographic and health characteristics of Sri Lankan adults. Preventive strategies should be based on population risk stratification of alcohol use.
背景:斯里兰卡酒精使用的可靠流行病学证据有限。本研究使用具有全国代表性的数据解决了这一差距。方法使用斯里兰卡2018/2019年非机构成年人国家研究的数据。加权数据使用描述性和逻辑回归技术进行分析。结果6473名成人中,平均年龄43.9岁(SD = 16.7);52.5%的女性),53.1%(95%置信区间;51.9%,54.3%)的男性和2.0%(95%置信区间;1.9%,2.1%)的女性目前(每年)饮酒。男性人均饮酒量为3.12升,女性为0.028升。男性酒精使用的预测因素包括年龄在30-39岁之间、僧伽罗族裔、中等教育程度、目前已婚以及处于中等财富五分位数;女性的预测因素包括年龄在30-39岁之间、印度泰米尔族裔、高等教育程度、寡妇或分居以及处于最高财富五分位数。有害饮酒(每周≥21个单位)仅在男性中观察到:14.1%。在男性中,吸烟、血压升高和自我评价不佳的健康状况与饮酒的可能性较高有关。饮酒对男性2型糖尿病和抑郁症有保护作用。结论斯里兰卡成年人酒精使用的患病率、分布和相关因素因人口统计学和健康特征而异。预防战略应以酒精使用的人口风险分层为基础。
{"title":"Epidemiology of alcohol use in Sri Lanka: Findings of the SLHAS national survey","authors":"Bilesha Perera ,&nbsp;Ravindra P. Rannan-Eliya ,&nbsp;Nilmini Wijemunige ,&nbsp;Sarath Samarage ,&nbsp;H.M.M. Herath ,&nbsp;Wasantha Jayawardene ,&nbsp;Mohammad R. Torabi","doi":"10.1016/j.gloepi.2025.100222","DOIUrl":"10.1016/j.gloepi.2025.100222","url":null,"abstract":"<div><h3>Background</h3><div>Reliable epidemiological evidence of alcohol use in Sri Lanka is limited. This study addressed this gap using nationally representative data.</div></div><div><h3>Methods</h3><div>Data from a 2018/2019 national study of non-institutionalized adults in Sri Lanka were used. Weighted data were analysed using descriptive and logistic regression techniques.</div></div><div><h3>Results</h3><div>Among 6473 adults (mean age 43.9 (<em>SD</em> = 16.7); 52.5 % women) surveyed, 53.1 % (95 %CI; 51.9 %, 54.3 %) of men and 2.0 % (95 % CI; 1.9 %, 2.1 %) of women were current (yearly) alcohol users. Per capita consumption of alcohol was 3.12 l for men and 0.028 l for women. Predictors of alcohol use in men included being aged 30–39 years, Sinhalese ethnicity, secondary education, currently married, and being in the middle wealth quintile and in women, being aged 30–39 years, Indian Tamil ethnicity, tertiary education, being a widow or separated, and being in the highest wealth quintile were the significant predictors of current alcohol use. Hazardous drinking (≥21 units per week) was observed only in men: 14.1 %. In men, smoking, elevated blood pressure and low self-rated health were related to higher likelihood of alcohol use. Alcohol use showed protective effects on type 2 diabetes and depression in men.</div></div><div><h3>Conclusions</h3><div>Prevalence, distribution and associated factors of alcohol use vary by demographic and health characteristics of Sri Lankan adults. Preventive strategies should be based on population risk stratification of alcohol use.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality rate of stroke and its determinants in Africa: An umbrella review of systematic review and meta-analysis 非洲中风死亡率及其决定因素:系统评价和荟萃分析的综合综述
Pub Date : 2025-10-02 DOI: 10.1016/j.gloepi.2025.100225
Addisu Getie , Mihretie Gedfew , Tegene Atamenta Kitaw , Gizachew Yilak , Melaku Bimerew

Introduction

Stroke is a significant clinical condition characterized by inadequate blood flow to the brain, resulting in cerebral function loss and potential death if not promptly treated. In developed countries, stroke incidence is decreasing due to efforts targeting risk factors like high blood pressure and smoking, though aging populations sustain high overall rates. Globally, stroke ranks among the top causes of death and disability, with Africa experiencing notably high stroke-related mortality rates. Understanding these trends and predictors is crucial for shaping effective healthcare strategies and interventions to reduce stroke mortality across the continent. Therefore, this umbrella review aimed to assess the pooled prevalence of stroke mortality and its associated predictors in Africa.

Method

This umbrella review systematically synthesized findings from systematic reviews and meta-analyses on stroke mortality rates in Africa, following established methodology. Various databases, including PubMed, Embase, Scopus, and others, were searched up to June 2024 for English-language studies reporting stroke mortality prevalence and determinants. Data were extracted using standardized methods in Excel, and study quality was assessed using the AMSTAR tool. Heterogeneity was measured using Higgin's I2 Statistics, and summary prevalence estimates were calculated with the Der Simonian-Laird random-effects model. Publication bias was assessed by visually inspecting funnel plots and conducting Egger's regression tests.

Result

In this umbrella review, data from nine systematic review and meta-analysis studies encompassed 341 primary studies with a total sample size of 170,501 stroke patients admitted to hospitals in Africa. The overall pooled prevalence of stroke mortality in Africa was 20.3 % (95 % CI: 17.3–23.2). Western Africa exhibited the highest prevalence at 27 % (95 % CI: 14.4–39.6), and hemorrhagic stroke patients had a notably higher mortality rate of 26.1 % (95 % CI: 24–28.3).

Conclusion

This study reveals significant variations in stroke mortality across Africa, with the highest prevalence reported in Western Africa and among hemorrhagic stroke patients. Factors associated with increased stroke mortality include severe neurological impairment (Glasgow Coma Scale <8), aspiration pneumonia, older age, vascular disease, female gender, lack of aspirin treatment, reduced renal function, and diabetes.
卒中是一种重要的临床疾病,其特征是脑血流量不足,如果不及时治疗,会导致脑功能丧失和潜在的死亡。在发达国家,由于针对高血压和吸烟等危险因素的努力,中风发病率正在下降,尽管老龄化人口的总体发病率仍然很高。在全球范围内,中风是造成死亡和残疾的主要原因之一,非洲与中风有关的死亡率特别高。了解这些趋势和预测因素对于制定有效的医疗保健策略和干预措施以降低整个非洲大陆的中风死亡率至关重要。因此,本综述旨在评估非洲卒中死亡率的总体患病率及其相关预测因素。方法本综述系统地综合了来自非洲卒中死亡率的系统综述和荟萃分析的结果,遵循既定的方法。各种数据库,包括PubMed, Embase, Scopus等,检索了截至2024年6月报告中风死亡率患病率和决定因素的英语研究。在Excel中使用标准化方法提取数据,并使用AMSTAR工具评估研究质量。异质性采用Higgin’s I2 Statistics测量,总患病率估计采用Der simonan - laird随机效应模型计算。通过视觉检查漏斗图和Egger回归检验来评估发表偏倚。在这项总括性综述中,来自9项系统综述和荟萃分析研究的数据包括341项主要研究,总样本量为170,501例非洲医院卒中患者。非洲卒中死亡率的总流行率为20.3% (95% CI: 17.3-23.2)。西非的患病率最高,为27% (95% CI: 14.4-39.6),出血性卒中患者的死亡率明显更高,为26.1% (95% CI: 24-28.3)。结论:该研究揭示了非洲卒中死亡率的显著差异,西非和出血性卒中患者的患病率最高。与卒中死亡率增加相关的因素包括严重的神经损伤(格拉斯哥昏迷量表<;8)、吸入性肺炎、年龄较大、血管疾病、女性、缺乏阿司匹林治疗、肾功能下降和糖尿病。
{"title":"Mortality rate of stroke and its determinants in Africa: An umbrella review of systematic review and meta-analysis","authors":"Addisu Getie ,&nbsp;Mihretie Gedfew ,&nbsp;Tegene Atamenta Kitaw ,&nbsp;Gizachew Yilak ,&nbsp;Melaku Bimerew","doi":"10.1016/j.gloepi.2025.100225","DOIUrl":"10.1016/j.gloepi.2025.100225","url":null,"abstract":"<div><h3>Introduction</h3><div>Stroke is a significant clinical condition characterized by inadequate blood flow to the brain, resulting in cerebral function loss and potential death if not promptly treated. In developed countries, stroke incidence is decreasing due to efforts targeting risk factors like high blood pressure and smoking, though aging populations sustain high overall rates. Globally, stroke ranks among the top causes of death and disability, with Africa experiencing notably high stroke-related mortality rates. Understanding these trends and predictors is crucial for shaping effective healthcare strategies and interventions to reduce stroke mortality across the continent. Therefore, this umbrella review aimed to assess the pooled prevalence of stroke mortality and its associated predictors in Africa.</div></div><div><h3>Method</h3><div>This umbrella review systematically synthesized findings from systematic reviews and meta-analyses on stroke mortality rates in Africa, following established methodology. Various databases, including PubMed, Embase, Scopus, and others, were searched up to June 2024 for English-language studies reporting stroke mortality prevalence and determinants. Data were extracted using standardized methods in Excel, and study quality was assessed using the AMSTAR tool. Heterogeneity was measured using Higgin's I<sup>2</sup> Statistics, and summary prevalence estimates were calculated with the Der Simonian-Laird random-effects model. Publication bias was assessed by visually inspecting funnel plots and conducting Egger's regression tests.</div></div><div><h3>Result</h3><div>In this umbrella review, data from nine systematic review and meta-analysis studies encompassed 341 primary studies with a total sample size of 170,501 stroke patients admitted to hospitals in Africa. The overall pooled prevalence of stroke mortality in Africa was 20.3 % (95 % CI: 17.3–23.2). Western Africa exhibited the highest prevalence at 27 % (95 % CI: 14.4–39.6), and hemorrhagic stroke patients had a notably higher mortality rate of 26.1 % (95 % CI: 24–28.3).</div></div><div><h3>Conclusion</h3><div>This study reveals significant variations in stroke mortality across Africa, with the highest prevalence reported in Western Africa and among hemorrhagic stroke patients. Factors associated with increased stroke mortality include severe neurological impairment (Glasgow Coma Scale &lt;8), aspiration pneumonia, older age, vascular disease, female gender, lack of aspirin treatment, reduced renal function, and diabetes.</div></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"10 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Global Epidemiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1