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Clinical efficacy of hepatic vein drainage guided hepatectomy for hepatocellular carcinoma 肝静脉引流引导下肝切除术治疗肝癌的临床疗效
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.013
Fu Xu, T. Min, Sun Shiquan, He Jian, Z. Tie, Chou Yudong, Mao Liang
Objective To investigate the clinical efficacy of hepatic venous drainage guided hepatectomy (HVDGH) for hepatocellular carcinoma. Methods The retrospective and descriptive study was conducted. The clinicopathological data of 10 patients with hepatocellular carcinoma who were admitted to Nanjing Drum Tower Hospital Affiliated to Nanjing University Medicine School from October 2015 to January 2018 were collected. There were 9 males and 1 female, aged from 35 to 68 years, with an average age of 57 years. Three-dimensional reconstruction of liver, hepatic vasculature, and carcinoma was performed in the 10 patients to evaluate the anatomy and variation of hepatic vasculature, and the spatial relationship between carcinoma and hepatic vasculature. Patients were performed right HVDGH, middle HVDGH, left and middle HVDGH, according to their conditions. Observation indicators: (1) preoperative three-dimensional reconstruction and planning; (2) surgical and postoperative conditions; (3) follow-up. Follow-up using outpatient examination and telephone interview was performed to detect tumor recurrence and metastasis of patients up to May 2018. Measurement data with normal distribution were described as average (range), and count data were described as absolute numbers. Results (1) Preoperative three-dimensional reconstruction and planning: of the 10 patients, 3 had the tumor located at S4 of the liver, 1 had the tumor located at S4 and S8 of the liver, 1 had the tumor located at S5, S6, and S7 of the liver, 4 had the tumor located at S6 and S7 of the liver, 1 had the tumor located at S6, S7, and S8 of the liver. All the 10 patients had tumor close to the main hepatic vein with a distance <5 mm, including 6 with the tumor adjacent to the right hepatic vein, 1 adjacent to the middle hepatic vein, and 3 adjacent to the left hepatic vein and the middle hepatic vein. The tumor diameter was 7.3 cm (range, 4.0-13.5 cm). The residual liver volume/standard liver volume (RLV/SLV) of 10 patients undergoing hepatic vein-preserving hepatectomy was 36.2% (range, 22.0%-46.0%), of which 7 had RLV/SLV less than 40.0%. The RLV/SLV of 10 patients undergoing HVDGH was 51.9% (range, 40.0%-61.0%). (2) Surgical and postoperative conditions: all the 10 patients underwent HVDGH successfully, including 6 with tumor adjacent to right hepatic vein undergoing right HVDGH, 1 with tumor adjacent to middle hepatic vein undergoing middle HVDGH, 3 with tumor adjacent to left and middle hepatic vein undergoing left and middle HVDGH. The operation time, volume of intraoperative blood loss, and the distance between surgical margin and carcinoma were 350 minutes (range, 240-470 minutes), 525 mL (range, 200-1 000 mL), and 8.3 mm (range, 5.0-20.0 mm). There was no postoperative complication such as hemorrhage, liver failure, or biliary fistula in 10 patients. The duration of postoperative hospital stay was 13 days (range, 11-21 days). (3) Follow-up: 10 patients were followed up for 4
目的探讨肝静脉引流引导下肝切除术(HVDGH)治疗肝细胞癌的临床疗效。方法采用回顾性和描述性研究。收集2015年10月至2018年1月入住南京大学医学院附属南京鼓楼医院的10例肝细胞癌患者的临床病理资料。男9例,女1例,年龄35-68岁,平均57岁。对10名患者进行了肝脏、肝血管系统和癌症的三维重建,以评估肝血管系统的解剖和变异,以及癌症与肝血管系统之间的空间关系。根据患者的情况,分别进行右HVDGH、中HVDGH和左HVDGH。观察指标:(1)术前三维重建及规划;(2) 手术和术后情况;(3) 后续行动。截至2018年5月,通过门诊检查和电话访谈进行随访,以检测患者的肿瘤复发和转移情况。正态分布的测量数据描述为平均值(范围),计数数据描述为绝对数。结果(1)术前三维重建及规划:10例患者中,3例肿瘤位于肝脏S4,1例肿瘤位于肝S4、S8,1例位于肝S5、S6、S7,4例位于肝S6、S7;1例位于肝脏S6、S7、S8。所有10例患者肿瘤均靠近肝主静脉且距离<5mm,其中6例肿瘤靠近右肝静脉,1例肿瘤靠近肝中静脉,3例肿瘤靠近左肝静脉和肝中静脉。肿瘤直径为7.3cm(范围4.0-13.5cm)。10例保留肝静脉肝切除术患者的残余肝体积/标准肝体积(RLV/SLV)为36.2%(22.0%-46.0%),其中7例RLV/SLV<40.0%,其中肝右静脉旁肿瘤6例,肝中静脉旁肿瘤1例,肝左中静脉旁瘤3例。手术时间、术中失血量和手术边缘与癌细胞之间的距离分别为350分钟(范围240-470分钟)、525毫升(范围200-1000毫升)和8.3毫米(范围5.0-20.0毫米)。10例患者术后无出血、肝功能衰竭或胆瘘等并发症。术后住院时间为13天(11~21天)。(3) 随访:10例患者随访4-31个月,中位随访时间为18个月。随访期间,10例患者总体情况良好,未发生肿瘤复发或转移。结论HVDGH治疗肝细胞癌安全有效,可通过术前三维重建软件编程。对于邻近或侵犯肝静脉的肿瘤,HVDGH不仅可以保留更多的肝实质,而且可以获得理想的切除边缘。关键词:肝肿瘤;肝癌;肝静脉引流区;三维重建;肝切除术;拥堵
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引用次数: 0
Analysis of risk factors for postoperative enterocutaneous fistula after inguinal hernia free tension repair 腹股沟疝无张力修补术后肠外瘘的危险因素分析
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.011
Chengbing Chu, Jie Chen, Yingmo Shen, Su-jun Liu, Shuo Yang, Jing Liu, Jin-xin Cao
Objective To analyze the risk factors for postoperative enterocutaneous fistula after inguinal hernia free tension repair. Methods The retrospective case-control study was conducted. The clinical data of 679 patients who underwent inguinal hernia free tension repair between January 2015 and September 2018 in Beijing Chao-Yang Hospital of Capital Medical University were collected. There were 646 males and 33 females, aged (65±12)years, with a range from 28 to 94 years. Observation indicators: (1) surgical situations of inguinal hernia free tension repair; (2) follow-up; (3) enterocutaneous fistula and its treatment; (4) risk factors for postoperative enterocutaneous fistula after inguinal hernia free tension repair. Follow-up by outpatient examination and telephone interview was performed to detect the postoperative enterocutaneous fistula up to June 2019. Measurement data with normal distribution were represented as Mean±SD. Count data were described as absolute numbers. Univariate analysis and multivariate analysis were done using the chi-square test and Logistic regression model, respectively. Results (1) Surgical situations of inguinal hernia free tension repair: 679 patients underwent inguinal hernia free tension repair. Of 679 patients, 215 underwent plug repair or mesh-plug repair, including 9 cases undergoing Plug repair only, 50 undergoing Millikan procedure, and 156 undergoing Rutkow procedure, other 464 underwent non-plug surgery, including 181 undergoing Lichtenstein procedure, 53 undergoing transinguinal preperitoneal hernia repair (TIPP), and 230 undergoing transabdominal preperitoneal patch repair (TAPP) and total extraperitoneal inguinal hernia repair (TEP). Polypropylene mesh or plug were used in all 679 cases. The operation time and volume of intraoperative blood loss were (61±14)minutes and (10±7)mL. There were 580 of 679 patients treated with prophylactic antibiotics. (2) Follow-up: 679 patients were followed up for 15-86 months, with a median time of 51 months. There were 12 male patients with postoperative enterocutaneous fistula, aged (69±8)years, with a range from 57 to 79 years, twelve patients with enterocutaneous fistula developed symptoms within the time of (42±25)months. (3) Enterocutaneous fistula and its treatment: of 12 patients with enterocutaneous fistula, 11 underwent plug repair or mesh-plug repair, and 1 undergwent TAPP(enterocutaneous fistula secondary to invasion of preperitoneal patch to intestines). The fistulas were located at inguinal region, with a diameter of 0.5-1.0 cm. In the 12 patients, of the 5 patients with sigmoid fistula, 4 underwent intestinal resection around the fistula, 1 underwent distal bowel closure and proximal colostomy. Six patients had enteric fistula, including 5 secondary to invasion of plug to intestines and 1 due to preperitoneal patch in TAPP, and they underwent resection of intestines with fistula combined with side-to-side intestial anastomosis, or laparoscopic sut
目的分析腹股沟疝无张力修补术后肠外瘘的危险因素。方法采用回顾性病例对照研究。收集2015年1月至2018年9月在首都医科大学北京朝阳医院接受腹股沟疝无张力修补术的679例患者的临床数据。男646例,女33例,年龄(65±12)岁,年龄28~94岁。观察指标:(1)腹股沟疝无张力修补术的手术情况;(2) 后续行动;(3) 肠皮瘘及其治疗;(4) 腹股沟疝无张力修补术后肠外瘘的危险因素。截至2019年6月,通过门诊检查和电话访谈进行了随访,以检测术后肠皮瘘。具有正态分布的测量数据表示为Mean±SD。计数数据被描述为绝对数。分别采用卡方检验和Logistic回归模型进行单因素分析和多因素分析。结果(1)腹股沟疝无张力修补术的手术情况:679例患者接受了腹股沟疝无压力修补术。在679名患者中,215名患者接受了填塞修复或网状填塞修复,其中9例仅接受填塞修复,50例接受Millikan手术,156例接受Rutkow手术,其他464例接受了非填塞手术,包括181例接受Lichtenstein手术,53例接受经角腹膜前疝修补术(TIPP),230例接受经腹部腹膜前补片修补术(TAPP)和全腹膜外腹股沟疝修补术(TEP)。679例均使用聚丙烯网或塞子。手术时间和术中出血量分别为(61±14)分钟和(10±7)mL。679名患者中有580人接受了预防性抗生素治疗。(2) 随访:679例患者随访15-86个月,中位随访时间为51个月。术后发生肠皮瘘的男性患者12例,年龄(69±8)岁,年龄从57岁到79岁不等,12例肠皮瘘患者在(42±25)个月内出现症状。(3) 肠皮瘘及其治疗:12例肠皮瘘患者中,11例接受了填塞或网状填塞修复,1例接受了TAPP(腹膜前补片侵犯肠道继发的肠皮瘘)治疗。瘘管位于腹股沟区,直径0.5-1.0cm。在12名患者中,5名乙状结肠瘘患者中,4名接受了瘘管周围的肠切除术,1名接受了远端肠闭合术和近端结肠造口术。6例患者出现肠瘘,其中5例继发于栓塞对肠的侵犯,1例由TAPP腹膜前补片引起,他们接受了带瘘肠切除术结合肠侧吻合,或腹腔镜缝合肠皮瘘的所有层和血清肌层。1例肠瘘和膀胱瘘患者接受了肠瘘切除术,并用3-0可吸收线将其缝合和嵌入。12例患者手术时间为(126±40)分钟。5名患者接受了清创术和引流术进行再次手术。12例患者住院时间为(37±11)天。(4) 腹股沟疝无张力修补术后发生肠皮瘘的危险因素:单因素分析结果显示,手术方法是腹股沟疝无压力修补术后肠皮瘘发生的相关因素(χ2=17.601,P<0.05)。多因素分析结果表明,疝塞修补或网片疝塞修补是一个独立的危险因素结论疝塞修补术或网塞修补术是腹股沟疝无张力修补术后发生肠皮瘘的独立危险因素。关键词:疝;腹股沟疝;无张力修复;插头;肠皮瘘;风险因素
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引用次数: 0
Selection of surgical methods for recurrent inguinal hernia and corresponding clinical efficacy 腹股沟疝复发手术方法的选择及临床疗效分析
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.009
Lisheng Wu, Jianwei Yu
Objective To investigate the choice of surgical methods for recurrent inguinal hernia and their corresponding clinical efficacy. Methods The retrospective cross-sectional study was conducted. The clinical data of 98 patients with recurrent inguinal hernia who were admitted to the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) between January 2015 and December 2017 were collected. There were 90 males and 8 females, aged (62±16)years, with a range from 18 to 84 years. According to the previous surgical approaches of patients and the interference degree to the preperitoneal space, size of the defects, type of recurrent inguinal hernia, and the surgeon′s mastery of laparoscopic hernia repair technology, corresponding surgical methods for recurrent inguinal hernia were selected. Observation indicators: (1) conditions of recurrent inguinal hernia; (2) conditions of reoperation; (3) follow-up. Follow-up using outpatient examiantion, telephone interview, and website APP was performed to detect the conditions of recurrent hernia and complications at 3-7 days, 1 month, 3 months, 6 months, and 12 months after operation up to December 2018. Measurement data with normal distribution were represented as Mean±SD, and measurement data with skewed distribution were represented as M (range). Count data were expressed as absolute numbers. Results (1) Conditions of recurrence inguinal hernia: the time to recurrence of inguinal hernia in 98 patients was 1.5 years (0.5 years, 4.0 years), ranging from 1 day to 40.0 years after operation. Five patients had recurrence more than 3 times. There were 47 cases classified as type R1, 21 cases as type R2, and 30 cases as type R3 according to Campanelli classification of recurrent hernias. Seventy-five of 98 patients were treated by anterior approach, including 26 undergoing Bassini repair, 16 undergoing Lichenstein repair, 11 undergoing Shouldice repair, 9 undergoing McVay repair, 5 undergoing Rutkow repair, 4 undergoing simple high ligation, and 4 undergoing Millikan repair. The time to postoperative recurrence was 3.0 years (0.7 year, 10.0 years). Twenty-three patients had been treated by posterior approach, including 2 undergoing reinforced preperitoneal Kugel repair combined with anterior approach, 1 undergoing Gilbert repair, and 1 undergoing Stoppa repair, with the time to postoperative recurrence of (3.2±1.6)years, 11 undergoing laparoscopic totally extraperitoneal prosthesis (TEP) and 8 undergoing laparoscopic transabdominal preperitoneal hernia repair (TAPP), with the time to postoperative recurrence of (1.5±0.9)years. (2) Conditions of reoperation: of the 75 patients firstly being treated by anterior approach, 62 underwent TAPP for reoperation, 9 underwent Kugel repair, and 4 underwent TEP, and the operation time was (66±25)minutes, (61±19)minutes, (70±26)minutes, respectively. Local anesthesia was used in 1 case with Kugel operation and general ane
目的探讨复发性腹股沟疝手术方法的选择及其临床疗效。方法采用回顾性横断面研究。收集2015年1月至2017年12月中国科学技术大学第一附属医院(安徽省立医院)收治的98例复发性腹股沟疝患者的临床资料。男性90例,女性8例,年龄(62±16)岁,年龄18 ~ 84岁。根据患者既往手术入路及对腹膜前间隙的干扰程度、缺损大小、腹股沟复发疝类型及术者对腹腔镜疝修补技术的掌握程度,选择相应的腹股沟复发疝手术方法。观察指标:(1)腹股沟疝复发情况;(二)再运行条件;(3)跟进。随访于术后3-7天、1个月、3个月、6个月、12个月至2018年12月,采用门诊检查、电话访谈、网站APP等方式检测疝复发及并发症情况。正态分布计量资料用Mean±SD表示,偏态分布计量资料用M(极差)表示。计数数据以绝对数字表示。结果(1)腹股沟疝复发情况:98例患者术后1天至40.0年,术后1.5年(0.5年、4.0年)至腹股沟疝复发时间。5例复发3次以上。根据Campanelli疝复发分型分为R1型47例,R2型21例,R3型30例。98例患者中75例采用前路入路,其中Bassini修复26例,Lichenstein修复16例,Shouldice修复11例,McVay修复9例,Rutkow修复5例,单纯高位结扎4例,Millikan修复4例。术后复发时间3.0年(0.7年,10.0年)。经后路入路治疗23例,其中强化腹膜前Kugel修补联合前路2例,Gilbert修补1例,Stoppa修补1例,术后复发时间(3.2±1.6)年,腹腔镜全腹膜外修复术(TEP) 11例,腹腔镜经腹腹膜前疝修补术(TAPP) 8例,术后复发时间(1.5±0.9)年。(2)再手术条件:75例首次行前路手术患者中,62例行TAPP再手术,9例行Kugel修复,4例行TEP,手术时间分别为(66±25)分钟、(61±19)分钟、(70±26)分钟。Kugel手术采用局麻1例,全麻74例。首次行后路疝修补术的23例患者中,13例疝环直径<2 cm者行利希滕斯坦修补术,10例疝环直径≥2 cm者行改良补片修补术再次手术。手术时间分别为(53±14)分钟和(58±14)分钟。硬膜外麻醉(Lichtenstein修补术)1例,局麻2例(Lichtenstein修补术1例,改良补片修补术1例),全麻20例。(3)随访:98例患者均随访1 ~ 48个月,中位随访时间18个月。随访期间无复发疝。术后早期疼痛31例,其中TAPP 11例,TEP 1例,Kugel修复5例,Lichtenstein修复7例,改良补片修复7例;慢性疼痛5例,TAPP 1例,Kugel修复1例,Lichtenstein修复1例,改良补片修复2例;血肿2例,TAPP 1例,Lichtenstein修复1例,TAPP积液3例。36例并发症患者经随访及对症支持治疗均得到改善。结论反复腹股沟疝手术方式的合理选择取决于既往手术是否干扰腹膜前间隙、缺损大小及分型、术者腹腔镜疝修补技术等,可达到较好的疗效。关键词:疝;腹股沟疝,成人;复发;腹腔镜检查;治疗的选择
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引用次数: 0
Discussion on the reoperation of recurrent inguinal hernia 腹股沟疝复发再手术的探讨
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.002
Heguang Huang
Inguinal hernia repair is a clinically common procedure to treat abdominal external hernia. More than 20 million hernias are estimated to be repaired every year around the world. With the continuous development of patch materials and endoscopy technology, various repair materials and surgical methods emerge in an endless stream. However, recurrence is always one of the inevitable complications after operation, and it has become the main cause of reoperation for patients. Recurrent inguinal hernia can be cured by surgical treatment. Due to that it is a complex disease with diverse clinical manifestations, difficult management and many complications, how to master the timing and technique of operation correctly, prevent postoperative complications, deal with the original patch, and give humanistic care has become the focus of attention of hernia surgeons. The author has discussed the reoperation of recurrent inguinal hernia in this paper. Key words: Hernia; Inguinal hernia; Recurrent hernia; Reoperation; Operation timing; Surgical procedure; Complications
腹股沟疝修补术是临床上常见的治疗腹外疝的方法。据估计,全世界每年有2000多万疝需要修复。随着贴片材料和内镜技术的不断发展,各种修复材料和手术方法层出不穷。然而,复发一直是术后不可避免的并发症之一,已成为患者再次手术的主要原因。复发性腹股沟疝可以通过手术治疗治愈。由于疝是一种临床表现多样、管理困难、并发症多的复杂疾病,如何正确掌握手术时机和技术,预防术后并发症,处理好原有的补片,给予人文关怀,已成为疝外科医生关注的焦点。本文讨论了复发性腹股沟疝的再手术治疗。关键词:疝;腹股沟疝;复发性疝;重新操作;操作时机;外科手术;并发症
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引用次数: 0
Clinical efficacy of Lichtenstein surgery for cirrhosis ascites complicated with inguinal hernia 利希滕斯坦手术治疗肝硬化腹水合并腹股沟疝的临床疗效
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.006
Xiaobin Li, Mengwei Wu, Rui Liu, Hongwei Yuan, Yimin Song
Objective To investigate the clinical efficacy of Lichtenstein surgery for cirrhosis ascites complicated with inguinal hernia (hernia ring diameter <3.0 cm). Methods The retrospective and descriptive study was conducted. The clinicopathological data of 50 patients who underwent Lichtenstein surgery for cirrhosis ascites complicated with inguinal hernia in the Peking Union Medical College Hosptal of Chinese Academy of Medical Science between January 2010 and January 2018 were collected. There were 42 males and 8 females, aged from 45 to 73 years, with an average age of 66 years. Observation indicators: (1) surgical and postoperative situations; (2) follow-up. Follow-up was conducted through outpatient examination and telephone interview to detect the hernia recurrence and survival of patients at 3, 6 months after operation and once every 6 months after 6 months up to January 2019. Measurement data with normal distribution were expressed as Mean±SD and measurement data with skewed distribution were expressed as M (range). Count data were expressed as absolute numbers and/or percentages. Results (1) Surgical and postoperative situations: 50 patients underwent operation successfully. The operation time and duration of postoperative hospital stay were (52±7)minutes and (4.0±1.8)days. Among the 50 patients, 1 case of postoperative wound fat liquefaction occurred and was healed after dressing change, 8 cases of scrotal edema effusion occurred and were recovered after being treated with suction, 3 cases of pain in groin area occurred and were relieved after symptomatic treatment, and 4 cases of urinary retention occurred and were cured after urethral catheterization and exercise of bladder. (2) Follow-up: 48 of the 50 patients were followed up, with a follow-up rate of 96%(48/50). The 48 patients was followed up for 12-36 months with a median time of 33 months. During the follow-up, 1 case of inguinal hernia recurred and 2 cases died of complications related to cirrhosis. Conclusion Lichtenstein surgery is safe and feasible for the cirrhosis ascites complicated with inguinal hernia (hernia ring diameter <3 cm). Key words: Hernia; Inguinal hernia; Hernia repair; Liver cirrhosis; Ascites
目的探讨Lichtenstein手术治疗肝硬化腹水并发腹股沟疝(疝环直径<3.0cm)的临床疗效。方法采用回顾性和描述性研究。收集2010年1月至2018年1月在中国医学科学院北京协和医院接受Lichtenstein肝硬化腹水并发腹股沟疝手术的50例患者的临床病理数据。男42例,女8例,年龄45~73岁,平均年龄66岁。观察指标:(1)手术及术后情况;(2) 后续行动。通过门诊检查和电话访谈进行随访,以检测患者在术后3个月、6个月以及截至2019年1月的6个月后每6个月一次的疝复发和生存率。正态分布的测量数据表示为Mean±SD,偏态分布的数据表示为M(范围)。计数数据表示为绝对数和/或百分比。结果(1)手术及术后情况:50例患者手术成功。手术时间和住院时间分别为(52±7)分钟和(4.0±1.8)天。50例患者中,1例术后伤口脂肪液化,换药后痊愈;8例阴囊水肿渗出,经抽吸治疗后痊愈,3例腹股沟区疼痛经对症治疗后得到缓解,4例尿潴留经导尿和膀胱运动后得到治愈。(2) 随访:对50例患者中的48例进行了随访,随访率为96%(48/50)。48名患者进行了12-36个月的随访,中位随访时间为33个月。在随访中,1例腹股沟疝复发,2例死于肝硬化相关并发症。结论Lichtenstein手术治疗肝硬化腹水并发腹股沟疝(疝环直径<3cm)是安全可行的。关键词:疝;腹股沟疝;疝修补术;肝硬化;腹水
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引用次数: 0
Technical tips on transabdominal preperitoneal hernioplasty 腹膜前疝修补术的技术要点
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.003
Shuang Chen
Transabdominal preperitoneal hernioplasty (TAPP) is an effective laparoscopic inguinal hernia repair procedure, and it is also the basis of current robotic assisted hernioplasty. Focusing on the future, the authors put forward new ideas and methods on how to achieve the development from standardization to intelligence, and to realize the artificial intelligence surgery. Using the concepts of point, line, and surface of geometric perspective can realize visualization and descriptiveness of techniques. At the same time, the procedure of TAPP is thoroughly explained and understood through the time axis and the spatial axis. Besides, the authors also present discussion and insights on the normative nature of TAPP methods, in order to realize normalization and standardization. Key words: Hernia; Inguinal hernia; Transabdominal preperitoneal hernioplasty; Technique; Laparoscopy
经腹腹膜前疝成形术(TAPP)是一种有效的腹腔镜腹股沟疝修补术,也是目前机器人辅助疝成形术的基础。展望未来,就如何实现从标准化到智能化的发展,实现人工智能手术提出了新的思路和方法。利用几何透视的点、线、面等概念,可以实现技术的可视化和描述性。同时,通过时间轴和空间轴对TAPP的程序进行了深入的解释和理解。此外,作者还对TAPP方法的规范性进行了探讨和见解,以实现规范化和标准化。关键词:疝;腹股沟疝;经腹腹膜前疝成形术;技巧;腹腔镜检查
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引用次数: 0
Intestinal flora as the potential target for nutritional support treatment in abdominal infection and its clinical significance 肠道菌群作为腹部感染营养支持治疗的潜在靶点及其临床意义
Q4 Medicine Pub Date : 2019-10-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.10.005
Chang Liu, Yanyan Dong, Zeyu Li
Intra-abdominal infections (IAIs) are common in the clinical practice, which include a variety of patholo-gical conditions. Severe IAIs can lead to sepsis, secondary organ dysfunction, and threaten the lives of patients. Patients with IAIs are under a high metabolic reaction, and often have gastrointestinal dysfunction, manifesting as impaired intestinal mucosal barrier function, out of control in intestinal flora regulation, and continuous loss of nutrients. The body is in a malnutrition condition, and body resistance severely declines, which further aggravates disease progression. Intestinal micro-ecology is the largest and most complex ecosystem in the human body. In the case of coexistence of many bacteria, the synergy and antagonism between different strains maintain the balance of digestive tract microecology. Intestinal flora and nutritional status under IAIs have their particularity. Understanding the mechanism of intestinal flora abnormalities under IAIs, reasonable and effective nutritional support treatment and management is essential for improving the prognosis of patients with IAIs. Key words: Critical illnes; Infection; Intra-abdominal infections; Intestinal flora; Nutritional support
腹内感染(IAIs)在临床实践中很常见,它包括多种病理条件。严重的iai可导致败血症、继发性器官功能障碍,并危及患者生命。iai患者处于高代谢反应状态,常出现胃肠道功能障碍,表现为肠黏膜屏障功能受损,肠道菌群调节失控,营养物质持续流失。身体处于营养不良状态,身体抵抗力严重下降,这进一步加剧了疾病的进展。肠道微生态是人体最大、最复杂的生态系统。在多种细菌共存的情况下,不同菌株之间的协同和拮抗作用维持了消化道微生态的平衡。iai下的肠道菌群和营养状况有其特殊性。了解IAIs下肠道菌群异常的发生机制,合理有效的营养支持治疗和管理,对改善IAIs患者的预后至关重要。关键词:危重症;感染;腹腔感染;肠道菌群;营养支持
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引用次数: 0
Analysis of safety and efficacy of irreversible electroporation hepatic ablation with high-frequency bipolar pulse in swine 高频双极脉冲不可逆电穿孔肝切除术的安全性和有效性分析
Q4 Medicine Pub Date : 2019-10-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.10.014
Jing Yuan, Shoulong Dong, Yuxiao Chen, Tingyuan Li, Chuang He, Liangshan Li, Lin Chen, C. Yao, Xuequan Huang
Objective To investigate the safety and efficacy of irreversible electroporation (IRE) hepatic ablation with high-frequency bipolar pulse in swine. Methods The experimental study was conducted. A total of 18 swines of either gender, aged (6.8+ 0.8)months with a range of 5.5-8.0 months, were collected from Animal Laboratory Center of Army Medical University. were randomly divided into 15 in experimental group and 3 in control group. The swines in experimental group underwent IRE hepatic ablation with high-frequency bipolar pulse, and 3 swines were chose randomly and underwent enhanced CT examination immediately after ablation, and at 3, 7, 14, and 28 days after ablation. The liver tissues were taken for histopathological examination. The swines in the control group underwent IRE hepatic ablation with high-frequency monopolar burst, and was performed enhanced CT examination at 3 days after ablation. Liver tissues were taken for histopathological examination. Observation indicators: (1) comparison of muscle contraction of siwnes between two groups; (2) imaging performance on enhanced CT after IRE ablation in the experimental group; (3) hepatic histopathological findings after IRE ablation in the experimental group; (4) comparison of apoptotic index in the ablation zone between two groups. The measurement data with normal distribution were expressed as Mean±SD, and comparison between groups was performed by the independent sample t test. Results (1) Comparison of muscle contraction between two groups: swines in both groups underwent ablation successfully. The degree of muscle contraction was (9.8±0.4)m/s2 and (48.6±0.5)m/s2 in the experimental group and in the control group, respectively, showing statistically significant difference between the two groups (t=-163.50, P<0.05). (2) Imaging performance on enhanced CT after IRE ablation in the experimental group: the enhanced CT examination of swines immediately after IRE ablation showed a low-density shadow and clear boundary in the ablation zone. There was no obvious abnormality in the ablation zone and its adjacent large vessels. No serious complications occurred after the ablation. The boundary between the ablation zone and the normal liver tissue of the experimental group gradually became blurred over time, and the ablation zone was gradually replaced by normal liver tissue. The ablation zone at the 28 days after ablation was significantly reduced or even disappeared on imaging of enhanced CT examination.The maximum diameter of the ablation zone was (1.81±0.17)cm immediately after ablation, (1.75±0.19)cm at the 3 days after ablation, (1.32±0.22)cm at the 7 days after ablation, (0.65±0.14)cm at the 14 days after ablation, (0.28±0.10)cm at the 28 days after ablation, respectively. (3) Hepatic histopathological findings after IRE ablation in the experimental group: the HE staining of ablated tissue immediately after ablation showed that the cells in the ablation zone were swollen, arranged
目的探讨高频双极脉冲不可逆电穿孔(IRE)肝切除术的安全性和有效性。方法进行实验研究。从陆军医科大学动物实验中心采集了18只性别的猪,年龄为(6.8+0.8)个月,范围为5.5-8.0个月。随机分为实验组15例和对照组3例。实验组用高频双极脉冲对猪进行IRE肝切除,随机选择3只猪,在切除后立即和切除后3、7、14、28天进行增强CT检查。取肝组织进行组织病理学检查。对照组的猪接受了高频单极子爆裂的IRE肝脏消融,并在消融后3天进行了增强CT检查。取肝组织进行组织病理学检查。观察指标:(1)两组大鼠肌肉收缩的比较;(2) 实验组IRE消融后增强CT成像表现;(3) 实验组IRE消融后的肝脏组织病理学表现;(4) 两组消融区细胞凋亡指数的比较。具有正态分布的测量数据表示为Mean±SD,组间比较采用独立样本t检验。结果(1)两组肌肉收缩情况比较:两组猪均成功消融。实验组和对照组的肌肉收缩程度分别为(9.8±0.4)m/s2和(48.6±0.5)m/s2,两组间差异有统计学意义(t=-163.50,P<0.05)。消融区及其邻近大血管未见明显异常。消融后未出现严重并发症。随着时间的推移,消融区与实验组正常肝组织的边界逐渐模糊,消融区逐渐被正常肝组织取代。消融术后28天的消融区在增强CT检查的成像上显著减少甚至消失。消融后即刻消融区的最大直径为(1.81±0.17)cm,消融后第3天为(1.75±0.19)cm;消融后第7天为(1.32±0.22)cm、消融后第14天为(0.65±0.14)cm和消融后第28天为(0.28±0.10)cm。(3) 实验组IRE消融后肝脏组织病理学表现:消融后即刻消融组织HE染色显示,消融区细胞肿胀,排列紊乱,部分针头周围可见出血。消融区胆管和血管完整,消融后3天可见大量深染细胞核,部分细胞核和凋亡小体部分溶解或裂解。消融区周围有大量炎性细胞浸润。von Willebrand因子染色观察到完整的血管和胆管内皮细胞,末端脱氧核苷酸转移酶介导的缺口末端标记染色观察到消融区大量细胞核染色较深的凋亡细胞,von-Kossa染色观察到部分沉积的深棕色钙盐。在消融后7、14、28天,观察到更多的新生肝细胞从消融区的外围向中心生长。在消融后14天和28天观察到平滑肌细胞增殖。消融后28天,用新细胞替换消融区。(4) 两组消融区凋亡指数比较:术后3天,实验组消融区的凋亡指数明显高于对照组(76.67%±0.04%vs.64.03%±0.05%,t=4.79,P<0.05),并且它比具有高频单极爆发的IRE消融具有更多的凋亡细胞。关键词:消融;猪;肝脏问题;高频双极脉冲;不可逆电穿孔
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引用次数: 0
Diagnosis and treatment of multiple liver myopericytoma 多发性肝肌外皮细胞瘤的诊断与治疗
Q4 Medicine Pub Date : 2019-10-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.10.017
Han Gao, Heng Cao, Yueshan Zhang, Baoming Yang
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引用次数: 0
Clinical efficacy of minimal access retroperitoneal pancreatic necrosectomy for infected pancreatic necrosis 小切口腹膜后胰腺坏死切除术治疗感染性胰腺坏死的临床疗效
Q4 Medicine Pub Date : 2019-10-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.10.010
Wei Zhou, J. Cui, S. Gou, T. Yin, J. Xiong, Chun-you Wang
Objective To investigate the clinical efficacy of minimal access retroperitoneal pancreatic necrosectomy (MARPN) for infected pancreatic necrosis (IPN). Methods The retrospective cohort study was conducted. The clinical data of 61 patients with IPN who were admitted to Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology between January 2014 and December 2017 were collected. There were 39 males and 22 females, aged 36-67 years, with a median age of 49 years. Of 61 patients, 40 undergoing open surgery were allocated into open group, and 21 undergoing MARPN were allocated into MARPN group. All the patients underwent surgical treatments after standard non-surgical treatments according to the Guidelines for the diagnosis and treatment of severe acute pancreatitis (2014 edition). Observation indicators: (1) intraoperative and postoperative situations; (2) follow-up. Follow-up using telephone interview or outpatient examination was performed to detect weight loss, pathoglycemia, steatorrhea, intestinal obstruction, and pancreatic portal hypertension for one year after surgery up to December 2017. Measurement data with normal distribution were represented as Mean±SD, and comparison between groups was analyzed using the t test. Count data were represented as absolute numbers or percentages, and comparison between groups was done using the chi-square test. Results (1) Intraoperative and postoperative situations: operation time, time to out-of-bed activity, time to initial food intake, cases with reoperation, cases with postoperative multiple organ dysfunction syndrome (MODS), incidence rate of postoperative complications, mortality, time to drainage-tube removal, duration of hospital stay, and hospital expenses were (77±20)minutes, (13.0±3.6)days, (9.0±2.7)days, 8, 9, 45.0%(18/40), 7.5%(3/40), (37.0±6.3)days, (49±8)days, (84 321±8 872)yuan in the open group, and (59±20)minutes, (2.7±0.9)days, (1.9±0.4)days, 6, 2, 19.0%(4/21), 0, (21.0±2.7)days, (39±6)days, (58 594±3 576)yuan in the MARPN group, respectively, showing no significant difference in the cases with reoperation (χ2=0.69, P>0.05) but significant differences in the other indices between the two groups (t=4.24, 9.61, 15.34, χ2=23.76, 4.02, 36.03, t=11.07, 5.93, 8.43, P 0.05). Conclusion MARPN for IPN is safe and reliable, with certain efficacy, which can effectively reduce incidence of postoperative complication, motality and shorten hospital stay. Key words: Pancreatitis; Infection; Retroperitoneal approach; Pancreatic necrosectomy
目的探讨小切口腹膜后胰腺坏死切除术(MARPN)治疗感染性胰腺坏死(IPN)的临床疗效。方法采用回顾性队列研究。收集2014年1月至2017年12月华中科技大学同济医学院附属协和医院收治的61例IPN患者的临床资料。男性39例,女性22例,年龄36 ~ 67岁,中位年龄49岁。61例患者中,40例行开放手术分为开放组,21例行MARPN手术分为MARPN组。所有患者均按照《严重急性胰腺炎诊治指南(2014年版)》进行标准非手术治疗后行手术治疗。观察指标:(1)术中、术后情况;(2)跟进。术后随访1年至2017年12月,采用电话随访或门诊检查,检测体重减轻、血糖升高、脂肪漏、肠梗阻和胰门脉高压。计量资料为正态分布,用Mean±SD表示,组间比较采用t检验。计数资料以绝对数字或百分比表示,组间比较采用卡方检验。(1)术中及术后情况:手术时间、下床活动时间、开始进食时间、再手术病例数、术后多器官功能障碍(MODS)病例数、术后并发症发生率、死亡率、拔管时间、住院时间、住院费用分别为(77±20)分钟、(13.0±3.6)天、(9.0±2.7)天、8、9、45.0%(18/40)、7.5%(3/40)、(37.0±6.3)天、(49±8)天、(84 321±8 872)元,开放组为(59±20)分钟、(2.7±0.9)天。MARPN组分别为(1.9±0.4)天、6、2、19.0%(4/21)、0、(21.0±2.7)天、(39±6)天、(58 594±3 576)元,再手术例数差异无统计学意义(χ2=0.69, P < 0.05),但两组间其他指标差异有统计学意义(t=4.24、9.61、15.34,χ2=23.76、4.02、36.03,t=11.07、5.93、8.43,P < 0.05)。结论MARPN治疗IPN安全可靠,具有一定疗效,可有效降低术后并发症发生率、死亡率、缩短住院时间。关键词:胰腺炎;感染;腹膜后途径;胰腺进行
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引用次数: 0
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中华消化外科杂志
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