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Retrospect of twenty years of development and prospect of bariatric and metabolic surgery in China 我国减肥代谢外科20年发展回顾与展望
Q4 Medicine Pub Date : 2019-09-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.09.002
Jingang Liu
Nowadays, the incidence of obesity and related metabolic diseases is increasing around the world, which seriously endangers the human health and the quality of life. Obesity has become the most prominent public health issue in the time. With the rapid development of surgical treatment of obesity combined with type 2 diabetes mellitus, bariatric surgery has gradually evolved into a new important branch of upper gastrointestinal surgery or gastrointestinal surgery, that is bariatric and metabolic surgery. To date, bariatric surgery has entered in China since twenty years ago. Following the steps of the rapid development of bariatric and metabolic surgery in the world, bariatric surgery has embarked on a solid and steady journey of development through seizing the opportunity, finding the right direction. On the way forward in the past twenty years, Chinese bariatric and metabolic surgery has not only faced setbacks and confusion, but also gained experience and lessons; it has encountered bottlenecks in its development and provided evidences from China. The number of surgeons in bariatric surgery is still limited compared with a large number of obese people. Therefore, there will be opportunities and challenges coexisting in the future. How to continuously improve the therapeutic effect of surgery, train more professional practitioners, break through the bottleneck, and seek faster development will be an important research topic in metabolic and bariatric surgery with the scientific evidence-based medicine accumulating. Key words: Obesity; Type 2 diabetes mellitus; Bariatric surgery; Bariatric and metabolic surgery; Retrospect and prospect
当今世界,肥胖及相关代谢性疾病的发病率不断上升,严重危害人类健康和生活质量。肥胖已经成为当时最突出的公共卫生问题。随着肥胖合并2型糖尿病外科治疗的快速发展,减肥外科逐渐发展成为上消化道外科或胃肠道外科的一个新的重要分支,即减肥和代谢外科。到目前为止,减肥手术已经进入中国二十年前。随着世界减肥和代谢外科的快速发展,减肥外科抓住机遇,找准方向,踏上了坚实而稳健的发展之旅。在过去的二十年里,中国减肥代谢外科在前进的道路上,不仅遇到了挫折和困惑,而且获得了经验和教训;它在发展中遇到了瓶颈,并为中国提供了证据。与大量肥胖者相比,从事减肥手术的外科医生数量仍然有限。因此,未来机遇与挑战并存。随着科学循证医学的积累,如何不断提高手术的治疗效果,培养更多的专业从业者,突破瓶颈,寻求更快的发展,将是代谢减肥手术的重要研究课题。关键词:肥胖;2型糖尿病;减肥手术;减肥和代谢手术;回顾与展望
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引用次数: 0
Value of multi-slice spiral CT angiography and image fusion technology in preoperative evaluation of laparoscopic radical resection of rectal cancer 多层螺旋CT血管造影及图像融合技术在腹腔镜直肠癌根治术术前评价中的价值
Q4 Medicine Pub Date : 2019-09-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.09.014
L. Bian, Danping Wu, Yigang Chen, Zhuiyang Zhang, Jianming Ni, Lei Zhang
Objective To explore the value of computed tomography angiography (CTA) and image fusion technology in preoperative evaluation of laparoscopic radical resection of rectal cancer. Methods The retrospective and descriptive study was conducted. The clinicopathological data of 60 patients who underwent laparoscopic radical resection of rectal cancer in the Affiliated Wuxi Second People′s Hospital of Nanjing Medical University from February 2018 to March 2019 were collected. There were 39 males and 21 females, aged from 45 to 81 years, with an average age of 67 years. All patients underwent abdominal multi-slice spiral computed tomography (CT) plain scan and dual-phase enhanced scan before operation. The original CT images were observed by multiplanar reconstruction and performed three-dimensional (3D) reconstruction of blood vessels by volume rendering. The CT images of arterial vessels with large density difference were abstracted by threshold segmentation and direct abstraction, and the CT images of venous vessels with small density difference were abstracted by region growing method. Then the 3D images of blood vessels were obtained after image fusion with red and blue pseudocolor added. All the 60 patients were performed laparoscopic radical resection of rectal cancer by the same surgical team, and were identified inferior mesenteric artery (IMA) and branches after being bared vessels, including anatomic course of left colonic artery (LCA), sigmoid artery (SA), and superior rectal artery (SRA). Observation indicators: (1) anatomic courses of IMA, LCA, SA, and SRA on the 3D images and their consistency with intraoperative anatomic courses; (2) the first branch of IMA and the distances from the root of IMA to the first branch and from the root of IMA to bifurcation point of the abdominal aorta on 3D images of blood vessels; (3) the spatial relationship between the horizontal level of LCA and the inferior mesenteric vein (IMV) on the 2D CT images and 3D images of blood vessels. Measurement data were represented as Mean±SD, and count data were represented as absolute numbers and percentages. Results (1) Anatomic courses of IMA, LCA, SA and SRA on the 3D images and their consistency with intraoperative anatomic courses: of the 60 patients, 31 (51.7%) had type Ⅰ anatomic course of IMA on the 3D images, with LCA and SA from the common trunk; 9 (15.0%) had type Ⅱ, with LCA and SA from the common trunk; 18 (30.0%) had type Ⅲ, with LCA, SA, and SRA from the common trunk; 2 (3.3%) had type Ⅳ, with no LCA. The consistency of anatomic courses of IMA, LCA, SA, and SRA on the 3D images with intraoperative anatomic courses of bared IMA, LCA, SA, and SRA was 100.0%(60/60). (2) The first branch of IMA and the distances from the root of IMA to its first branch and from the root of IMA to the bifurcation point of abdominal aorta on 3D images of blood vessels: of the 60 patients, 49 (81.7%) had LCA as the first branch of IMA, 11 (18.3%) had SRA or SA as
目的探讨计算机断层造影(CTA)和图像融合技术在腹腔镜癌症直肠癌根治术前评估中的价值。方法采用回顾性和描述性研究。收集南京医科大学附属无锡市第二人民医院2018年2月至2019年3月60例腹腔镜癌症直肠癌根治术患者的临床病理资料。男39例,女21例,年龄45~81岁,平均67岁。所有患者术前均行腹部多层螺旋CT平扫和双期增强扫描。通过多平面重建观察原始CT图像,并通过体积绘制进行血管的三维(3D)重建。采用阈值分割和直接提取的方法提取密度差较大的动脉血管的CT图像,采用区域生长法提取密度差较小的静脉血管的CT图。然后在图像融合后获得血管的3D图像,并添加红蓝假彩色。60例患者均由同一手术组行腹腔镜癌症直肠癌根治术,经显露血管后确定肠系膜下动脉(IMA)及其分支,包括左结肠动脉(LCA)、乙状结肠动脉(SA)和直肠上动脉(SRA)的解剖路线。观察指标:(1)IMA、LCA、SA和SRA在三维图像上的解剖过程及其与术中解剖过程的一致性;(2) IMA的第一分支以及IMA的根部到第一分支以及从IMA的根到腹主动脉的分叉点的距离;(3) 血管的2D CT图像和3D图像上LCA水平水平与肠系膜下静脉(IMV)之间的空间关系。测量数据表示为Mean±SD,计数数据表示为绝对数和百分比。结果(1)IMA、LCA、SA和SRA在三维图像上的解剖过程及其与术中解剖过程的一致性:60例患者中,31例(51.7%)在三维图像中有Ⅰ型IMA解剖过程,其中LCA和SA来自总干;Ⅱ型9例(15.0%),共干LCA和SA;Ⅲ型18例(30.0%),LCA、SA、SRA均来自主干;Ⅳ型2例(3.3%),无LCA。IMA、LCA、SA和SRA在三维图像上的解剖过程与裸IMA、LC A、SA、SRA术中解剖过程的一致性为100.0%(60/60),49例(81.7%)以LCA为IMA的第一分支,11例(18.3%)以SRA或SA为IMA第一分支。在血管三维图像上,IMA的根部到其第一分支的距离和IMA的根到腹主动脉分叉点的距离分别为(41±6)cm和(42±7)cm。(3) LCA水平水平与血管二维CT和三维图像IMV的空间关系:60例患者中排除2例Ⅳ型患者。在其余58名患者的2D CT图像中,39名(67.2%)患者在IMV附近有LCA,19名(32.8%)患者在IMA根水平面IMV远端有LCA。在其余58例患者的血管3D图像中,37例(63.8%)的LCA位于IMV的腹侧,21例(36.2%)的LCA。结论Muiti切片CTA和图像融合技术能直观显示IMA及其分支的解剖过程和变化,具有较高的临床应用价值。关键词:直肠肿瘤;癌症;癌症直肠根治术;血管重建;肠系膜下动脉;术前评估;腹腔镜检查
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引用次数: 0
New onset cholecystolithiasis after bariatric surgery and countermeasures 减肥手术后新发胆囊结石及对策
Q4 Medicine Pub Date : 2019-09-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.09.016
Tianyi Zhang
Cholecystolithiasis is one of the long-term complications after bariatric surgery, of which the exact cause is still unclear. Based on the recent domestic and international literature, the contributing factors for new onset cholecystolithiasis after bariatric surgery and countermeasures are reviewed in this article. Key words: Obesity; Cholecystolithiasis; Bariatric surgery; Bariatric and metabolic surgery; Long-term complications
胆囊结石是减肥手术后的长期并发症之一,其确切原因尚不清楚。本文结合国内外文献,对减肥手术后新发胆囊结石的诱因及对策进行综述。关键词:肥胖;胆囊结石;减肥手术;减肥和代谢手术;长期并发症
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引用次数: 0
Clinical application value of symmetrical three-hole laparoscopic sleeve gastrectomy 对称三孔腹腔镜袖状胃切除术的临床应用价值
Q4 Medicine Pub Date : 2019-09-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.09.009
Lei Gao, Yangxi Hu, Desheng Hu, Ying Li, Mutian Niu, Hansong Liu, Huali Meng
Objective To investigate the clinical application value of symmetrical three-hole laparoscopic sleeve gastrectomy (LSG). Methods The retrospective and descriptive study was conducted. The clinical data of 232 patients with obesity who were admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from April 2017 to December 2018 were collected. There were 40 males and 192 females, aged (32±8)years, with a range of 17-63 years. All the 232 patients underwent symmetrical three-hole LSG. Observation indicators: (1) surgical and postoperative conditions; (2) complications; (3) follow-up. Follow-up was conducted by telephone interview and WeChat to collect the patient satisfaction with cosmetic effects of wounds at 3 months after surgery up to March 2019. Measurement data with normal distribution were expressed as Mean±SD. Count data were expressed as absolute numbers or percentages. Results (1) Surgical and postoperative conditions: of the 232 patients, 230 underwent symmetrical three-hole LSG successfully, without conversion to open surgery. Two patients had one puncture hole added due to spleen bleeding to help pull the omentum to stop bleeding, and no spleen hemorrhage recurred after improving the surgical procedure. Of the 232 patients, the operation time, volume of intraoperative blood loss, and duration of postoperative hospital stay were (115±7)minutes, (10±5)mL, and (3.0±0.8)days. (2) Complications: of the 232 patients, 10 had postoperative complications of fat liquefaction in the umbilical incision, and were cured after repeated dressing changes. All patients had no serious complications such as gastrointestinal bleeding, abdominal bleeding, or gastric fistula. (3) Follow-up: of the 232 patients, 230 undergoing successful symmetrical three-hole LSG were followed up for 3 months. Of the 230 patients, 3 were dissatisfied with the cosmetic effects of wounds, 12 were satisfied, and 215 were very satisfied. The satisfaction rate was 98.70%(227/230). Conclusion Symmetrical three-hole LSG is safe and feasible, with a good cosmetic effects of wounds. Key words: Obesity; Bariatric surgery; Bariatric and metabolic surgery; Symmetrical three-hole method; Sleeve gastrectomy; Laparoscopy
目的探讨对称三孔腹腔镜袖状胃切除术(LSG)的临床应用价值。方法采用回顾性和描述性研究。收集郑州大学附属郑州中心医院2017年4月至2018年12月收治的232例肥胖患者的临床资料。男40例,女192例,年龄(32±8)岁,年龄17-63岁。232例患者均行对称三孔LSG。观察指标:(1)手术及术后情况;(2) 并发症;(3) 后续行动。通过电话采访和微信进行随访,收集截至2019年3月手术后3个月患者对伤口美容效果的满意度。具有正态分布的测量数据表示为Mean±SD。计数数据用绝对数或百分比表示。结果(1)手术和术后情况:232例患者中,230例成功地接受了对称三孔LSG,没有转为开放手术。两名患者因脾出血增加了一个穿刺孔,以帮助拉动网膜止血,改进手术程序后没有脾出血复发。232例患者的手术时间、术中失血量和术后住院时间分别为(115±7)分钟、(10±5)mL和(3.0±0.8)天。所有患者均无胃肠道出血、腹部出血或胃瘘等严重并发症。(3) 随访:232例患者中,230例成功接受对称三孔LSG,随访3个月。230名患者中,3人对伤口美容效果不满意,12人满意,215人非常满意。满意率为98.70%(227/230)。结论对称三孔LSG是安全可行的,具有良好的创面美容效果。关键词:肥胖;减肥手术;减肥和代谢手术;对称三孔法;袖状胃切除术;腹腔镜检查
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引用次数: 0
Application value of quantitative computed tomography for evaluation of changes in abdominal fat after laparoscopic Roux-en-Y gastric bypass in obese patients 定量计算机断层扫描评价肥胖患者腹腔镜Roux-en-Y胃旁路术后腹部脂肪变化的应用价值
Q4 Medicine Pub Date : 2019-09-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.09.010
Hui Han, Chenxin Zhang, Xiao-guang Cheng, Shan Miao, Ye Zhang, Xinwei Liu, Hongkai Gao
Objective To evaluate the application value of quantitative computed tomography for evaluation of changes in abdominal fat after laparoscopic Roux-en-Y gastric bypass in obese patients. Methods The retrospective and descriptive study was conducted. The clinical data of 52 obese patients who underwent laparoscopic Roux-en-Y gastric bypass in the Third Medical Center of Chinese PLA General Hospital from March 2011 to February 2012 were collected. There were 24 males and 28 females, aged (43±9)years, with the range of 23-62 years. All the 52 patients underwent laparoscopic Roux-en-Y gastric bypass. Observation indicators: (1) surgical and postoperative conditions; (2) changes in anthropometric indices; (3) follow-up. Follow-up using outpatient examination was performed to detect complications of patients at 1, 3, 6, 12 months after surgery up to February 2013. Measurement data with normal distribution were represented as Mean±SD, repeated measurement data were analyzed using repeated ANOVA. Count data were represented as absolute numbers. Results (1) Surgical and postoperative conditions: all the patients underwent laparoscopic Roux-en-Y gastric bypass successfully, without conversion to open surgery. The volume of intraoperative blood loss, operation time, and duration of hospital stay were (25±11)mL, (78±14)minutes, and (11±2)days. (2) Changes in anthropometric indices: the body mass index (BMI), fat mass, free fat mass, total abdominal fat volume (TAFV), total subcutaneous fat volume (TSFV), and total visceral fat volume (TVFV) of all the 52 patients were (31.8±1.8)kg/m2, (39.4±4.1)kg, (50.2±6.0)kg, (11 703±3 899)cm3, (7 418±2 969)cm3, and (4 314±1 692)cm3 before surgery, (28.5±1.4)kg/m2, (33.0±1.1)kg, (49.7±4.6)kg, (11 016±3 713)cm3, (7 044±2 970)cm3, (3 969±1 443)cm3 at 3 months after surgery, (27.1±1.7)kg/m2, (30.2±1.3)kg, (45.4±3.1)kg, (9 406±4 452)cm3, (6 442±3 307)cm3, and (2 964±1 694)cm3 at 6 months after surgery, (24.4±2.4)kg/m2, (32.6±1.1)kg, (48.6±2.7)kg, (7 612±3 029)cm3, (5 623±2 650)cm3, and (1 826±360)cm3 at 12 months after surgery, respectively, there were significant differences in the changes of these indices (F=130.2, 30.3, 4.9, 25.6, 11.9, 16.5, P 0.05). The BMI, fat mass, TAFV, and TVFV at 6 months after surgery had significant differences compared with those before surgery (P 0.05). The BMI, fat mass, TAFV, TSFV, and TVFV at 12 months after surgery had significant differences compared with those before surgery (P 0.05). (3) Follow-up: all the 52 patients have completed the follow-up after surgery and the remission number of obesity was 35. No complications such as anastomotic hemorrhage, obstruction, or anastomotic leakage occured in all the 52 patients. Conclusion Laparoscopic Roux-en-Y gastric bypass can reduce abdominal visceral fat significantly, while quantitative computed tomography can help to evaluate the distribution of abdominal visceral fat accurately. Key words: Obesity; Gastric bypass su
目的评价定量计算机断层扫描在肥胖患者腹腔镜Roux-en-Y胃旁路手术后腹部脂肪变化评价中的应用价值。方法采用回顾性和描述性研究。收集2011年3月至2012年2月在解放军总医院第三医疗中心行腹腔镜Roux-en-Y胃旁路术的52例肥胖患者的临床资料。男性24例,女性28例,年龄(43±9)岁,年龄范围23 ~ 62岁。52例患者均行腹腔镜Roux-en-Y胃旁路术。观察指标:(1)手术及术后情况;(2)人体测量指数的变化;(3)跟进。随访时间为术后1、3、6、12个月至2013年2月,采用门诊检查检查患者并发症。计量资料呈正态分布用Mean±SD表示,重复计量资料采用重复方差分析。计数数据以绝对数字表示。结果(1)手术及术后情况:所有患者均成功行腹腔镜Roux-en-Y胃旁路手术,未转开腹手术。术中出血量、手术时间、住院时间分别为(25±11)mL、(78±14)min、(11±2)d。(2)人体测量指标的变化:52例患者术前体重指数(BMI)、脂肪质量、游离脂肪质量、总腹脂肪体积(TAFV)、总皮下脂肪体积(TSFV)、总内脏脂肪体积(TVFV)分别为(31.8±1.8)kg/m2、(39.4±4.1)kg、(50.2±6.0)kg、(11 703±3 899)cm3、(7 418±2 969)cm3、(4 314±1 692)cm3、(28.5±1.4)kg/m2、(33.0±1.1)kg、(49.7±4.6)kg、(11 016±3 713)cm3、(7 044±2 970)cm3、(3 969±1 443)cm3、(27.1±1.7)kg/m2、(30.2±1.3)kg、(45.4±3.1)kg、(9 406±4 452)cm3。术后6个月分别为(6 442±3 307)cm3、(2 964±1 694)cm3、(24.4±2.4)kg/m2、(32.6±1.1)kg、(48.6±2.7)kg、(7 612±3 029)cm3、(5 623±2 650)cm3、(1 826±360)cm3,差异均有统计学意义(F=130.2、30.3、4.9、25.6、11.9、16.5,P < 0.05)。术后6个月BMI、脂肪量、TAFV、TVFV与术前比较差异有统计学意义(P < 0.05)。术后12个月BMI、脂肪量、TAFV、TSFV、TVFV与术前比较差异有统计学意义(P < 0.05)。(3)随访:52例患者均完成术后随访,肥胖缓解人数35例。52例患者均未发生吻合口出血、梗阻、吻合口漏等并发症。结论腹腔镜Roux-en-Y胃旁路术可明显减少腹部内脏脂肪,定量计算机断层扫描可准确评估腹部内脏脂肪的分布。关键词:肥胖;胃分流术;定量计算机断层扫描;内脏脂肪;Laparscopy
{"title":"Application value of quantitative computed tomography for evaluation of changes in abdominal fat after laparoscopic Roux-en-Y gastric bypass in obese patients","authors":"Hui Han, Chenxin Zhang, Xiao-guang Cheng, Shan Miao, Ye Zhang, Xinwei Liu, Hongkai Gao","doi":"10.3760/CMA.J.ISSN.1673-9752.2019.09.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2019.09.010","url":null,"abstract":"Objective \u0000To evaluate the application value of quantitative computed tomography for evaluation of changes in abdominal fat after laparoscopic Roux-en-Y gastric bypass in obese patients. \u0000 \u0000 \u0000Methods \u0000The retrospective and descriptive study was conducted. The clinical data of 52 obese patients who underwent laparoscopic Roux-en-Y gastric bypass in the Third Medical Center of Chinese PLA General Hospital from March 2011 to February 2012 were collected. There were 24 males and 28 females, aged (43±9)years, with the range of 23-62 years. All the 52 patients underwent laparoscopic Roux-en-Y gastric bypass. Observation indicators: (1) surgical and postoperative conditions; (2) changes in anthropometric indices; (3) follow-up. Follow-up using outpatient examination was performed to detect complications of patients at 1, 3, 6, 12 months after surgery up to February 2013. Measurement data with normal distribution were represented as Mean±SD, repeated measurement data were analyzed using repeated ANOVA. Count data were represented as absolute numbers. \u0000 \u0000 \u0000Results \u0000(1) Surgical and postoperative conditions: all the patients underwent laparoscopic Roux-en-Y gastric bypass successfully, without conversion to open surgery. The volume of intraoperative blood loss, operation time, and duration of hospital stay were (25±11)mL, (78±14)minutes, and (11±2)days. (2) Changes in anthropometric indices: the body mass index (BMI), fat mass, free fat mass, total abdominal fat volume (TAFV), total subcutaneous fat volume (TSFV), and total visceral fat volume (TVFV) of all the 52 patients were (31.8±1.8)kg/m2, (39.4±4.1)kg, (50.2±6.0)kg, (11 703±3 899)cm3, (7 418±2 969)cm3, and (4 314±1 692)cm3 before surgery, (28.5±1.4)kg/m2, (33.0±1.1)kg, (49.7±4.6)kg, (11 016±3 713)cm3, (7 044±2 970)cm3, (3 969±1 443)cm3 at 3 months after surgery, (27.1±1.7)kg/m2, (30.2±1.3)kg, (45.4±3.1)kg, (9 406±4 452)cm3, (6 442±3 307)cm3, and (2 964±1 694)cm3 at 6 months after surgery, (24.4±2.4)kg/m2, (32.6±1.1)kg, (48.6±2.7)kg, (7 612±3 029)cm3, (5 623±2 650)cm3, and (1 826±360)cm3 at 12 months after surgery, respectively, there were significant differences in the changes of these indices (F=130.2, 30.3, 4.9, 25.6, 11.9, 16.5, P 0.05). The BMI, fat mass, TAFV, and TVFV at 6 months after surgery had significant differences compared with those before surgery (P 0.05). The BMI, fat mass, TAFV, TSFV, and TVFV at 12 months after surgery had significant differences compared with those before surgery (P 0.05). (3) Follow-up: all the 52 patients have completed the follow-up after surgery and the remission number of obesity was 35. No complications such as anastomotic hemorrhage, obstruction, or anastomotic leakage occured in all the 52 patients. \u0000 \u0000 \u0000Conclusion \u0000Laparoscopic Roux-en-Y gastric bypass can reduce abdominal visceral fat significantly, while quantitative computed tomography can help to evaluate the distribution of abdominal visceral fat accurately. \u0000 \u0000 \u0000Key words: \u0000Obesity; Gastric bypass su","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"18 1","pages":"859-863"},"PeriodicalIF":0.0,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45083094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical evaluation of clinical complete response to neoadjuvant chemoradiotherapy for rectal cancer 癌症新辅助放化疗临床完全缓解的临床评价
Q4 Medicine Pub Date : 2019-08-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.08.004
Yi Xiao, R. Sun
Neochemoradiotherapy has been implemented in the multidisciplinary therapy for advanced rectal cancer. The patients with complete response after neothemoradiation could avoid surgical resection and thereafter might be free of surgical complications, as well as functional impairment. However, the preoperative evaluated clinical complete response is not equally to the pathologic complete response after surgery. The accurate methods to evaluate the status of complete response remained controversy. Based on the digital rectal examination and endoscopic observation, rectal MRI and endorectal ultrasound could verify the integrity of mucosa and the structural changes in rectal wall. These preoperative staging methods, as well as PET-CT and needle biopsy, had been widely used, but with a low sensitivity. Key words: Rectal neoplasms; Rectal cancer; Neoadjuvant chemoradiotherapy; Clinical complete response; Magnetic resonance imaging, rectal; Ultrasound, rectal
新放化疗已在晚期直肠癌的多学科治疗中得到应用。新放疗后完全缓解的患者可以避免手术切除,此后可能没有手术并发症和功能损害。然而,术前评估的临床完全缓解并不等同于术后的病理完全缓解。评估完全缓解状态的准确方法仍存在争议。在直肠指检和内镜观察的基础上,直肠MRI和直肠内超声可以验证直肠粘膜的完整性和直肠壁的结构改变。这些术前分期方法,以及PET-CT和穿刺活检,已被广泛使用,但灵敏度较低。关键词:直肠肿瘤;直肠癌;新辅助化疗;临床完全缓解;直肠磁共振成像;超声波,直肠
{"title":"The clinical evaluation of clinical complete response to neoadjuvant chemoradiotherapy for rectal cancer","authors":"Yi Xiao, R. Sun","doi":"10.3760/CMA.J.ISSN.1673-9752.2019.08.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2019.08.004","url":null,"abstract":"Neochemoradiotherapy has been implemented in the multidisciplinary therapy for advanced rectal cancer. The patients with complete response after neothemoradiation could avoid surgical resection and thereafter might be free of surgical complications, as well as functional impairment. However, the preoperative evaluated clinical complete response is not equally to the pathologic complete response after surgery. The accurate methods to evaluate the status of complete response remained controversy. Based on the digital rectal examination and endoscopic observation, rectal MRI and endorectal ultrasound could verify the integrity of mucosa and the structural changes in rectal wall. These preoperative staging methods, as well as PET-CT and needle biopsy, had been widely used, but with a low sensitivity. \u0000 \u0000 \u0000Key words: \u0000Rectal neoplasms; Rectal cancer; Neoadjuvant chemoradiotherapy; Clinical complete response; Magnetic resonance imaging, rectal; Ultrasound, rectal","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"18 1","pages":"726-730"},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45537797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress in cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy for peritoneal metastasis of colorectal cancer 细胞减灭术联合腹腔高温化疗治疗癌症腹膜转移的研究进展
Q4 Medicine Pub Date : 2019-08-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.08.008
Zhi-chao Fu, Jianwen Liu, Jingwen Fan
Colorectal cancer peritoneal metastasis has traditionally been considered as one of the end-stage manifestations. Recently, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy achieved promising results in prolonging survival of patients and reducing tumor recurrences. Many guidelines suggested that the combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is an acceptable treatment for peritoneal metastasis. This article highlighted the treatment method, reviewed the latest evidence in treatment of colorectal cancer peritoneal metastasis and explored future direction. Key words: Colorectal neoplasms; Colorectal cancer; Peritoneal metastasis; Hyperthermic intraperitoneal chemotherapy; Cytoreductive surgery
结直肠癌腹膜转移历来被认为是终末期的表现之一。近年来,细胞减少手术联合腹腔内高温化疗在延长患者生存期和减少肿瘤复发率方面取得了可喜的效果。许多指南建议,结合细胞减少手术和腹腔内高温化疗是一种可接受的治疗腹膜转移。本文重点介绍了结直肠癌腹膜转移的治疗方法,综述了治疗的最新证据,并探讨了未来的发展方向。关键词:结直肠肿瘤;结直肠癌;腹膜转移;腹腔热化疗;Cytoreductive手术
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引用次数: 0
Evaluation of defecation function after laparoscopic-assisted transanal total mesorectal excision for low rectal cancer and influencing factors analysis 腹腔镜辅助经肛门全直肠炎切除术治疗低位癌症后排便功能评价及影响因素分析
Q4 Medicine Pub Date : 2019-08-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.08.010
Wei-hua Tong, Liang He, Luyao Zhang, Jiaxin Zhang, M. Li, Jianfeng Mu, Quan Wang
Objective To evaluate the defecation function of patients with low rectal cancer after laparoscopic-assisted transanal total mesorectal excision (TaTME), and analyze the influencing factors. Methods The retrospective case-control study was conducted. The clinicopathological data of 55 patients with low rectal cancer who underwent laparoscopic-assisted TaTME in the First Hospital of Jilin University from May 2017 to December 2018 were collected. There were 39 males and 16 females, aged (60±11)years, with a range from 24 to 80 years. Among the 55 patients, 21 were in TNM stage Ⅰ, 14 were in TNM stage Ⅱ, and 20 were in TNM stage Ⅲ; 24 were in pathological stage T1-2 and 31 were in pathological stage T3. Observation indicators: (1) surgical and postoperative conditions; (2) follow-up; (3) analysis of influencing factors for postoperative defecation function. Follow-up was performed using questionnaires by telephone interview to detect the complications at 3 and 6 months after surgery up to June 2019. The measurement data with normal distribution were expressed as Mean±SD, and comparison between groups was done using the t test. Count data were expressed as absolute numbers or percentages, and comparison between groups was analyzed using the chi-square test or Fisher exact probability. Univariate and multivariate analyses were performed using logistic regression models. Results (1) Surgical and postoperative conditions: 55 patients successfully underwent laparoscopic-assisted TaTME without conversion to open surgery. The operation time, volume of intraoperative blood loss, diameter of postoperative pathological specimen, time to urinary catheter removal, distance between the anastomostic stoma and anal verge, and tumor diameter were (246±62)minutes, (69±27)mL, (3.5±0.7) cm, (2.1±0.9)days, (2.4±0.5)cm, and (3.9±1.6)cm, respectively. (2) Follow-up: 55 patients were followed up at 3 months and 6 months after surgery, and the low anterior resection syndrome questionnaires were completed. Among the 55 patients, 35 had low anterior resection syndrome at 3 months after surgery, and 24 had low anterior resection syndrome at 6 months after surgery, showing a significant difference (χ2=4.42, P 5 cm were independent risk factors affecting the defecation function of patients at 3 months after surgery (odds ratio=1.135, 6.057, 95% confidence interval: 1.089-1.323, 1.206-30.435, P<0.05). The distance between the anastomotic stoma and anal verge <2 cm was an independent risk factor affecting the defecation function of patients at 6 months after surgery (odds ratio=2.724, 95% confidence interval: 1.982-3.066, P<0.05). Conclusions The incidence of low anterior resection syndrome after laparoscopic-assisted TaTME for low rectal cancer is high. Distance between the anastomotic storna and anal verge and tumor diameter are independent risk factors for the postoperative defecation founction. Key words: Rectal neoplasms; Rectal cancer; Transanal tot
目的评价腹腔镜辅助经肛直肠全系膜切除术(TaTME)后低位直肠癌患者的排便功能,并分析影响因素。方法采用回顾性病例对照研究。收集2017年5月至2018年12月在吉林大学第一医院行腹腔镜辅助TaTME治疗的55例低位直肠癌患者的临床病理资料。男性39例,女性16例,年龄(60±11)岁,年龄24 ~ 80岁。55例患者中,TNM期Ⅰ21例,TNM期Ⅱ14例,TNM期Ⅲ20例;病理分期T1-2期24例,病理分期T3期31例。观察指标:(1)手术及术后情况;(2)跟进;(3)术后排便功能影响因素分析。随访时间为术后3个月和6个月,随访至2019年6月。计量资料符合正态分布,用Mean±SD表示,组间比较采用t检验。计数数据以绝对数字或百分比表示,组间比较采用卡方检验或Fisher精确概率进行分析。采用logistic回归模型进行单因素和多因素分析。结果(1)手术及术后情况:55例患者成功行腹腔镜辅助TaTME手术,未转开腹手术。手术时间、术中出血量、术后病理标本直径、拔除导尿管时间、吻合口与肛缘距离、肿瘤直径分别为(246±62)min、(69±27)mL、(3.5±0.7)cm、(2.1±0.9)d、(2.4±0.5)cm、(3.9±1.6)cm。(2)随访:55例患者分别于术后3个月和6个月随访,填写下前切除术综合征问卷。55例患者中,术后3个月出现低前切除综合征35例,术后6个月出现低前切除综合征24例,差异有统计学意义(χ2=4.42, P 5 cm是影响患者术后3个月排便功能的独立危险因素,优势比分别为1.135、6.057,95%可信区间分别为1.089 ~ 1.323、1.206 ~ 30.435,P<0.05)。吻合口距肛缘距离<2 cm是影响术后6个月患者排便功能的独立危险因素(优势比=2.724,95%可信区间:1.982-3.066,P<0.05)。结论腹腔镜下低位直肠癌TaTME术后低位前切除术综合征发生率高。吻合口与肛缘的距离和肿瘤直径是影响术后排便功能的独立危险因素。关键词:直肠肿瘤;直肠癌;经肛门全肠系膜切除术;低位前切除术综合征;Laparocopy
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引用次数: 0
Clinical efficacy of three-dimensional visualization technique combined with enhanced recovery after surgery in the treatment of hepatolithiasis 三维可视化技术结合术后强化恢复治疗肝内胆管结石的临床疗效
Q4 Medicine Pub Date : 2019-08-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.08.014
C. Fang, Lin-yun He, Wen Zhu, Haoyu Hu, Jian Yang, N. Zeng, Yingfang Fan, S. Wen, N. Xiang
Objective To investigate the clinical efficacy of three-dimensional visualization technique (3DVT) combined with enhanced recovery after surgery (ERAS) in the treatment of hepatolithiasis. Methods The retrospective cohort study was conducted. The clinicopathological data of 64 patients with hepatolithiasis who were admitted to Zhujiang Hospital of Southern Medical University from November 2015 to August 2018 were collected. There were 17 males and 47 females, aged from 30 to 82 years, with a median age of 55 years. Of the 64 patients, 23 who completed preoperative assessment and planning using 3DVT, and furthermore received ERAS for perioperative management were divided into 3DVT + ERAS group, and 41 who received preoperative assessment merely under the guidance of 3DVT, combined with conventional perioperative management were divided into 3DVT + conventional group. Observation indicators: (1) preoperative CT and 3DVT assessment; (2) perioperative conditions; (3) follow-up. The follow-up was conducted by outpatient service, e-mail or telephone interview to detect the postoperative recurrence of hepatolithiasis up to March 2019. The measurement data with normal distribution were expressed as Mean±SD, and the t test was used for comparison between groups. The measurement data with skewed distribution were expressed as M (P25, P75), and the Mann-Whitney U test was used for comparison between groups. The count data were expressed as absolute numbers or percentages, and the comparison between groups was performed using the chi-square test or Fisher exact probability. Results (1) Preoperative CT and 3DVT assessment: 23 patients in the 3DVT + ERAS group underwent preoperative CT examination and 3DVT assessment, the consistency between CT results and intraoperative findings was 91.3%(21/23), and the consistency between 3DVT results and intraoperative findings was 95.7%(22/23). Fourty-one patients in the 3DVT + conventional group underwent preoperative CT examination and 3DVT assessment, the consistency between CT results and intraoperative findings was 90.2%(37/41), and the consistency between 3DVT results and intraoperative findings was 95.1%(39/41). (2) Perioperative conditions: the volume of intraoperative blood loss, duration of postoperative hospital stay, postoperative total bilirubin, postoperative direct bilirubin, postoperative albumin, postoperative alanine aminotransferase, postoperative aspartate aminotransferase and postoperative hemoglobin were 50 mL (10 mL, 100 mL), 8 days (7 days, 9 days), 12 μmol/L (9 μmol/L, 16 μmol/L), 6 μmol/L (4 μmol/L, 8 μmol/L), (37±4)g/L, 44 U/L (18 U/L, 85 U/L), 32 U/L (20 U/L, 65 U/L), (117±18)g/L in the 3DVT + ERAS group, and 100 mL (50 mL, 300 mL), 13 days (10 days, 16 days), 17 μmol/L (12 μmol/L, 33 μmol/L), 11 μmol/L (7 μmol/L, 21 μmol/L), (29±6)g/L, 78 U/L (43 U/L, 122 U/L), 121 U/L (72 U/L, 176 U/L), (106±13)g/L in the 3DVT + conventional group, respectively; there were significant differences
目的探讨三维可视化技术(3DVT)联合术后增强恢复(ERAS)治疗肝内胆管结石的临床疗效。方法采用回顾性队列研究。收集2015年11月至2018年8月南方医科大学珠江医院收治的64例肝内胆管结石患者的临床病理资料。男性17例,女性47例,年龄30 ~ 82岁,中位年龄55岁。64例患者中,23例采用3DVT完成术前评估和计划,并接受ERAS进行围手术期管理的患者分为3DVT + ERAS组,41例仅在3DVT指导下进行术前评估并结合常规围手术期管理的患者分为3DVT +常规组。观察指标:(1)术前CT、3DVT评估;(2)围手术期情况;(3)跟进。随访至2019年3月,采用门诊、邮件或电话随访等方式,了解术后肝内胆管结石复发情况。计量资料符合正态分布,用Mean±SD表示,组间比较采用t检验。偏态分布的计量资料用M (P25, P75)表示,组间比较采用Mann-Whitney U检验。计数数据以绝对数字或百分比表示,组间比较采用卡方检验或Fisher精确概率。(1)术前CT及3DVT评估:3DVT + ERAS组23例患者行术前CT检查及3DVT评估,CT结果与术中表现一致性为91.3%(21/23),3DVT结果与术中表现一致性为95.7%(22/23)。3DVT +常规组41例患者术前行CT检查及3DVT评估,CT结果与术中表现一致性为90.2%(37/41),3DVT结果与术中表现一致性为95.1%(39/41)。(2)围手术期条件:3DVT + ERAS组术中出血量、术后住院时间、术后总胆红素、术后直接胆红素、术后白蛋白、术后丙氨酸转氨酶、术后天冬氨酸转氨酶、术后血红蛋白分别为50 mL (10 mL、100 mL)、8 d (7 d、9 d)、12 μmol/L (9 μmol/L、16 μmol/L)、6 μmol/L (4 μmol/L、8 μmol/L)、(37±4)g/L、44 U/L (18 U/L、85 U/L)、32 U/L (20 U/L、65 U/L)、(117±18)g/L;3DVT +常规组分别为100 mL (50 mL、300 mL)、13天(10天、16天)、17 μmol/L (12 μmol/L、33 μmol/L)、11 μmol/L (7 μmol/L、21 μmol/L)、(29±6)g/L、78 U/L (43 U/L、122 U/L)、121 U/L (72 U/L、176 U/L)、(106±13)g/L;两组间差异有统计学意义(Z=-3.084, -4.827, -2.953, -3.632, t=5.261, Z=-2.960, -4.625, t=2.773, P<0.05)。3DVT + ERAS组2例发生肺部感染,2例发生胸腔积液,4例患者经治疗均治愈。3DVT +常规组发生胆瘘1例,肺部感染4例,胸腔积液5例,均经充分腹腔引流、抗生素治疗、胸腔穿刺术治愈。两组患者均无围手术期死亡。(3)随访:64例患者随访6 ~ 36个月,中位时间23个月。随访期间,3DVT + ERAS组无肝内胆管结石复发,3DVT +常规组超声证实肝内胆管结石复发1例。两组均未发生胆管癌。结论3DVT联合ERAS治疗肝内胆管结石有效、安全、可行,可加快术后肝功能恢复,从而提高围手术期恢复,同时改善患者预后。关键词:肝内胆管结石;三维可视化;增强术后恢复;功效;诊断;管理
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引用次数: 0
Prevention and treatment of complications of transanal total mesorectal excision 经肛门全肠系膜切除术并发症的防治
Q4 Medicine Pub Date : 2019-08-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.08.007
A. Wu, Guoli He
Transanal total mesorectal excision is a new surgical procedure which has emerged in the recent years. This procedure performs a "bottom-to-up" resection of the rectum and its surrounding mesenteries through the anus, which provides better view compared with laparoscopic or open total mesorectal excision. However, it is undeniable that as a new surgical procedure, transanal total mesorectal excision is also bound to have some complications of surgery. Therefore, how to prevent and treat the complications of transanal total mesorectal excision is still a problem that must be faced in the future. This article intends to review the prevention and treatment of surgical complications and provide some experience for the development of transanal total mesorectal excision. Key words: Transanal total mesorectal excision; Complications; Prevention; Treatment
经肛直肠系膜全切除术是近年来兴起的一种新型手术方式。该手术通过肛门对直肠及其周围肠系膜进行“自下而上”的切除,与腹腔镜或开放式全肠系膜切除术相比,它提供了更好的视野。但不可否认的是,作为一种新型的外科手术方式,经肛门全肠系膜切除术也必然存在一些手术并发症。因此,如何预防和治疗经肛门全肠系膜切除术的并发症仍然是今后必须面对的问题。本文拟就手术并发症的预防和处理进行综述,为经肛门全肠系膜切除术的发展提供一些经验。关键词:经肛直肠系膜全切除术;并发症;预防;治疗
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