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Application value of enhanced recovery after surgery in the laparoscopic surgery for cholecystolithiasis comorbid with choledocholithiasis 术后强化恢复在腹腔镜胆囊结石合并胆总管结石手术中的应用价值
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.007
Y. Mei, Ji-Hu Jia, Jun Ding, Li Chen, Jun Wang, P. Zeng, Wen-Ping Li, Kun Xiong, Wei Chen, C. Feng, K. Leng, Guo-xing Wang, Yan Luo, Chao Du, Libo Luo, J. Peng
Objective To explore the clinical application value of enhanced recovery after surgery (ERAS) in the laparoscopic surgery for cholecystolithiasis comorbid with choledocholithiasis. Methods The prospective study was conducted. The clinicopathological data of 52 patients with cholecystolithiasis comorbid with choledocholithiasis who were admitted to the Third Affiliated Hospital of Zunyi Medical University from September 2016 to September 2018 were collected. Patients were divided into 2 groups by random number table: patients in observation group received laparoscopic cholecystectomy + choledocholithotomy + choledochoscopic exploration + T-tube drainage (or primary suture of common bile duct) and perioperative management guided by the concept of enhanced recovery after surgery (ERAS), and patients in control group received traditional perioperative management. Observation indicators: (1) surgical situations; (2) postoperative situations; (3) postoperative complications; (4) postoperative pain scores; (5) changes in hepatic function and blood routine during perioperative period. Follow-up using outpatient examination and telephone interview was performed to detect complications during the postoperative 6 months up to March 2019. Measurement data with normal distribution were represented as Mean±SD, and comparison between groups was analyzed using the paired t test or repeated ANOVA. Count data were described as absolute numbers and percentages, and comparison between groups was analyzed using the chi-square test or Fisher exact probability. Results Fifty-two patients were screened for eligibility, including 20 males and 32 females, aged 25-68 years, with an average age of 53 years. There were 30 patients in the observation group and 22 in the control group. (1) Surgical situations: the operation time and volume of intraoperative blood loss were (133±19)minutes and (47±21)mL in the observation group, and (136±22)minutes and (49±23)mL in the control group, respectively, showing no significant difference between the two groups (t=-0.386, -0.211, P>0.05). (2) Postoperative situations: time to out-of-bed activity, time to initial food intake, time to first anal flatus, duration of postoperative hospital stay, and hospital expenses were (18±4)hours, (19±5)hours, (28±2)hours, (4.0±1.0)days, and (1.82±0.22)×104 yuan in the observation group, and (29±7)hours, (46±9)hours, (37±4)hours, (6.6±1.6)days, and (2.25±0.29)×104 yuan in the control group, respectively, showing significant differences between the two groups (t=-7.054, -14.169, -9.426, -6.582, -5.809, P 0.05). Conclusion ERAS is safe and effective in the laparoscopic surgery for choledocholithiasis comorbid with cholecystolithiasis. Key words: Choledocholithiasis; Cholecystolithiasis; Enhanced recovery after surgery; Efficacy; Laparoscopy
目的探讨增强术后恢复(ERAS)在腹腔镜胆囊结石合并胆总管结石手术中的临床应用价值。方法采用前瞻性研究。收集遵义医科大学附属第三医院2016年9月至2018年9月收治的52例胆囊结石合并胆总管结石患者的临床病理资料。按随机数表将患者分为2组:观察组采用腹腔镜胆囊切除术+胆总管切开取石+胆道镜探查+T管引流(或胆总管一期缝合)及术后强化恢复(ERAS)理念指导的围手术期管理,对照组采用传统围手术期处理。观察指标:(1)手术情况;(2) 术后情况;(3) 术后并发症;(4) 术后疼痛评分;(5) 围手术期肝功能和血常规的变化。在截至2019年3月的术后6个月内,通过门诊检查和电话采访进行了随访,以发现并发症。具有正态分布的测量数据表示为Mean±SD,并使用配对t检验或重复ANOVA分析各组之间的比较。计数数据描述为绝对数和百分比,并使用卡方检验或Fisher精确概率分析各组之间的比较。结果筛选出52例符合条件的患者,其中男性20例,女性32例,年龄25~68岁,平均年龄53岁。观察组30例,对照组22例。(1) 手术情况:观察组手术时间和术中失血量分别为(133±19)分钟和(47±21)mL,对照组为(136±22)min和(49±23)mL,两组差异无统计学意义(t=-0.386,-0.211,P>0.05),观察组第一次肛门排气时间、术后住院时间和住院费用分别为(18±4)小时、(19±5)小时、、(28±2)小时和(4.0±1.0)天和(1.82±0.22)×104元,对照组分别为(29±7)小时、【46±9】小时、【37±4】小时、(6.6±1.6)天和【2.25±0.29】×104元,两组比较有显著性差异(t=-7.054,-14.169,-9.426,-6.582,-5.809,P<0.05)。关键词:胆总管综合征;胆囊结石;术后恢复增强;功效;腹腔镜检查
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引用次数: 0
Diagnosis and treatment of biliary pancreatic duct dilatation 胆胰管扩张症的诊断与治疗
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.011
M. He, Xinsen Xu, Wei Chen, Wei Wang, Linhua Yang, R. Hua, Yong-wei Sun, Kewei Li
Objective To summarize the diagnosis and treatment of biliary pancreatic duct dilatation. Methods The retrospective and descriptive study was conducted. The clinical data of 22 patients with biliary pancreatic duct dilatation who were admitted to Renji Hospital of Shanghai Jiaotong University School of Medicine between October 2013 to September 2017 were collected. There were 6 males and 16 females, aged from 33 to 82 years, with an average age of 66 years. Surgical exploration was decided according to clinical symptoms, results of laboratory test and imaging examinations. For patients with space occupying lesions, surgical procedure was selected based on results of pathological examination. Patients without surgical exploration or space occupying lesions were allocated into follow-up. Observation indicators: (1) surgical exploration; (2) relationship of clinical symptoms and preoperative examinations with surgical exploration positive for space occupying lesions; (3) surgical treatment; (4) follow-up. Follow-up using outpatient examination was performed on patients up to October 2018. Follow-up was performed on patients with positive surgical exploration to detect postoperative complications.For patients with positive results of imaging examinations, no jaundice, normal laboratory indicators or mild abnormality, liver function, tumor markers and B-ultrasound were re-examined each month, and computed tomography (CT) and magnetic resonance imaging (MRI) was performed once every 3 months. Surgical exploration was performed when total bilirubin (TBil) or tumor markers showed a progressive increase. Follow-up was performed on patients with negative results of imaging examination, jaundice, and mildly elevated CA19-9. TBil and CA19-9 were re-examined monthly, and if they were progressively elevated, patients were transferred to surgical exploration. For patients with negative results of imaging examination, no symptoms, and negative laboratory test, liver function, tumor markers, and B-ultrasound were re-examined once every 3 months, and enhanced CT and MRI were re-examined once every 6 months within one year. Follow-up was performed once every 6 months during the second year, and once a year after two years. Measurement data with normal distribution were represented as Mean±SD, and comparison between groups was analyzed using the t test. Count data were descibed as absolute numbers, and they were analyzed using the chi-square test under R×C chart or Fisher exact probability. Results (1) Surgical exploration: of 22 patients, 11 underwent surgical exploration, and 11 underwent follow-up. Of the 11 patients with surgical exploration, 4 were positive for space occupying lesions including 1 of false negative, and 7 were negative for space occupying lesions. (2) Relationship of clinical symptoms and preoperative examinations with surgical exploration positive for space occupying lesions. ① Relationship of clinical symptoms and laboratory test
目的总结胆道胰管扩张的诊断和治疗方法。方法采用回顾性和描述性研究。收集2013年10月至2017年9月上海交通大学医学院仁济医院收治的22例胆道胰管扩张患者的临床资料。男6例,女16例,年龄33 ~ 82岁,平均年龄66岁。根据临床症状、实验室检查和影像学检查结果决定手术探查。对于占位性病变患者,根据病理检查结果选择手术方式。没有手术探查或占位性病变的患者被分配到随访组。观察指标:(1)手术探查;(2)临床症状与术前检查与占位性病变手术探查阳性的关系;(3)手术治疗;(4)随访。对患者进行门诊检查随访至2018年10月。对手术探查阳性的患者进行随访,观察术后并发症。影像学检查阳性,无黄疸,实验室指标正常或轻度异常,每月复查肝功能、肿瘤标志物、b超,每3个月复查CT、MRI 1次。当总胆红素(TBil)或肿瘤标志物显示进行性升高时,进行手术探查。影像学检查阴性、黄疸、CA19-9轻度升高的患者进行随访。每月复查TBil和CA19-9,如果逐渐升高,则转行手术探查。对影像学检查阴性、无症状、实验室检查阴性的患者,每3个月复查一次肝功能、肿瘤标志物、b超,1年内每6个月复查一次CT、MRI增强检查。第二年每6个月随访1次,两年后每年随访1次。计量资料为正态分布,用Mean±SD表示,组间比较采用t检验。计数数据被描述为绝对数字,并使用R×C图表或Fisher精确概率下的卡方检验进行分析。结果(1)手术探查:22例患者中11例行手术探查,11例随访。11例手术探查患者中,占位性病变阳性4例,假阴性1例,占位性病变阴性7例。(2)临床症状与术前检查与占位性病变手术探查阳性的关系。①临床症状及实验室检查与占位性病变探查阳性的关系:黄疸与占位性病变探查阳性有显著相关性(P < 0.05)。PET-CT与占位性病变手术探查阳性无显著相关性(P < 0.05)。③影像学检查、实验室检查与占位性病变手术探查阳性的关系:影像学检查阳性合并TBil、CA19-9升高与占位性病变手术探查阳性显著相关(P < 0.05)。(3)手术治疗:11例患者中有9例手术探查符合标准程序。9例患者中,4例发现胆胰十二指肠交界处占位性病变(3例行胰十二指肠切除术,1例行十二指肠乳头部分切除术),5例阴性探查行胆总管切开t管引流(1例术后1个月无法夹住t管,影像学发现胆管下端梗阻;第一次手术后3个月再次手术确诊为胰头癌。2例患者未遵循探查程序,仅根据术前影像学发现行儿童手术,未进行术中病理检查。术后病理检查分别为慢性壶腹和慢性胰腺炎。(4)随访:22例患者随访12 ~ 60个月,中位随访时间36个月。11例手术探查患者术后2例胃瘫,1例胆漏,1例切口感染,经对症治疗后好转。4例患者行阳性探查手术,随访无复发。 5例阴性探查患者行胆总管切开t管引流,1例确诊为胰头癌行胰十二指肠切除术,4例术后2个月行t管胆道造影取t管。随访期间,实验室检查及影像学检查均未见阳性征象。两例行胰十二指肠切除术的患者无复发。随访11例患者,术前腹痛10例,随访中腹痛3例,症状消失7例。实验室检查没有异常。结论影像学检查阳性合并黄疸、CA19-9升高是胆管扩张患者手术探查的绝对指征。那些不符合这一标准的患者应分配到随访中。若术中未见病理阳性结果,应终止手术,转患者随访。反对胆道吻合术或胆道支架置入术。关键词:胆胰管扩张;黄疸;肿瘤标志物;成像检查;外科勘查;后续
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引用次数: 0
Clinicopathological characteristics and prognostic factors of cardial mixed adenoneuroendocrine carcinoma 贲门混合性腺神经内分泌癌的临床病理特征及预后因素
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.013
Yangyang Sun, L. Qian, W. Gu, Gengfang Wang, Wei Gao, X. Geng, Xudong Zhang, Xiaoli Zhou
Objective To investigate the clinicopathological characteristics of cardial mixed adenoneuroendocrine carcinoma (MANEC) and analyze its prognostic factors. Methods The retrospective and descriptive study was conducted. The clinicopathological data of 34 patients with primary cardial MANEC who were admitted to the Changzhou No.2 People′s Hospital of Nangjing Medical University from January 2008 to January 2018 were collected. There were 20 males and 14 females, aged from 39 to 81 years, with an average age of 66 years. All the 34 patients underwent resection of cardia cancer and postoperative pathological examination. Observation indicators: (1) surgery and treatment; (2) clinical manifestations and pathological conditions; (3) pathological examination of surgical resection specimens; (4) follow-up and survival; (5) analysis of prognostic factors. Follow-up using outpatient examination and telephone interview was conducted to detect the survival of patients and tumor recurrence and metastasis up to December 2018. Measurement data with normal distribution were represented as Mean±SD. Measurement data with skewed distribution were expressed as M (range). Count data were expressed as absolute numbers or percentages. Kaplan-Merier method was used to calculate the survival time and rate and draw the survival curve, and log-rank test was used for the survival analysis. Univariate and multivariate analyses were performed using the COX proportional risk model. Results (1) Surgery and treatment: all the patients underwent surgery successfully and postoperative systemic chemotherapy based on cisplatin + etoposide. (2) Clinical manifestations and pathological conditions: patients had epigastric discomfort, abdominal pain and abdominal distension as the first symptoms. Of 34 patients, number of males, cases with age ≥60 years, cases with esophageal involvement, cases with stable microsatellite, cases with higher CA19-9, cases with elevated cancer embryonic antigen, cases of tumor pathologic TNM stage Ⅲ-Ⅳ, cases with tumor diameter ≥5 cm, cases with vascular tumor emboli, cases with positive lymph node metastasis, cases with nerve invasion were 20, 29, 31, 28, 4, 3, 29, 30, 27, 30, 29, respectively. (3) Pathological examination of surgical excision specimens: the masses of patients were mainly ulcer-type, with the diameter of 3.0-8.4 cm. Of the 34 patients, 1 had tumor infiltrated into submucosa, 5 infiltrated into muscle layer, 18 infiltrated into serosal layer, and 10 infiltrated into extra-serous fibrous adipose tissues. Microscopy examination showed that all tumors were composed of two components including adenocarcinoma and neuroendocrine carcinoma, and the two components accounted for more than 30%. Among adenocarcinoma components of the 34 patients, 14 were poorly differentiated tubular adenocarcinoma, 6 were mucinous adenocarcinoma, 6 were moderately differentiated tubular adenocarcinoma, 5 were low-adhesion carcinoma, 1 was highly differe
目的探讨心脏混合性腺神经内分泌癌(MANEC)的临床病理特点及影响预后的因素。方法采用回顾性和描述性研究。收集2008年1月至2018年1月南京医科大学常州市第二人民医院收治的34例原发性心脏MANEC患者的临床病理资料。男性20例,女性14例,年龄39 ~ 81岁,平均年龄66岁。34例患者均行贲门癌切除术及术后病理检查。观察指标:(1)手术与治疗;(2)临床表现及病理情况;(3)手术切除标本的病理检查;(4)随访和生存;(5)预后因素分析。随访采用门诊检查和电话随访,随访至2018年12月,了解患者生存情况及肿瘤复发转移情况。计量资料为正态分布,用Mean±SD表示。偏态分布的测量数据用M(极差)表示。计数数据以绝对数字或百分比表示。采用Kaplan-Merier法计算生存时间和生存率,绘制生存曲线,采用log-rank检验进行生存分析。采用COX比例风险模型进行单因素和多因素分析。(1)手术及治疗:所有患者均顺利完成手术,术后以顺铂+依托泊苷为基础进行全身化疗。(2)临床表现及病理情况:患者以上腹不适、腹痛、腹胀为首发症状。34例患者中,男性20例、年龄≥60岁、累及食管、微卫星稳定、CA19-9较高、癌胚抗原升高、肿瘤病理TNM分期Ⅲ-Ⅳ、肿瘤直径≥5 cm、血管肿瘤栓塞、淋巴结转移阳性、神经侵犯分别为20、29、31、28、4、3、29、30、27、30、29例。(3)手术切除标本病理检查:患者肿块以溃疡型为主,直径3.0-8.4 cm。34例患者中肿瘤浸润粘膜下层1例,浸润肌肉层5例,浸润浆膜层18例,浸润浆膜外纤维脂肪组织10例。镜检显示所有肿瘤均由腺癌和神经内分泌癌两种成分组成,两种成分占30%以上。34例患者的腺癌成分中,低分化管状腺癌14例,粘液腺癌6例,中分化管状腺癌6例,低粘连癌5例,高分化管状腺癌1例,乳头状腺癌2例。34例患者神经内分泌癌成分中,小细胞型10例,大细胞型24例。34例患者中,腺癌与神经内分泌癌紧密相邻但不混淆的10例,腺癌与神经内分泌癌交叉混合的24例。34例神经内分泌癌免疫组化检查显示突触素、嗜铬素A和神经细胞粘附分子阳性。腺癌组分中广谱细胞角蛋白、细胞角蛋白8/18和细胞角蛋白7阳性。(4)随访与生存:34例患者随访8.0 ~ 68.0个月,中位时间53.7个月。34例患者存活21-49个月,中位时间为35个月。1、3、5年生存率分别为93.31%、53.60%、20.62%。(5)预后因素分析:单因素分析结果显示,CA19-9、肿瘤直径、血管内肿瘤血栓、肿瘤病理TNM分期、淋巴结转移、微卫星检测、组织学分型是影响心脏MANEC患者预后的相关因素(风险比分别为1.724、0.327、1.401、1.612、1.542、1.876、0.945,95%可信区间:1.226 - -3.467, 0.218 - -0.776, 1.171 - -4.432, 0.694 - -4.054, 0.987 - -3.776, 1.217 - -4.341, 0.614 - -2.115, P < 0.05)。多因素分析结果显示,肿瘤病理TNM分期Ⅲ-Ⅳ、淋巴结转移阳性、微卫星稳定、神经内分泌癌为主要组织学分型是影响心脏MANEC患者预后的独立危险因素(优势比为1.667、1.441、1.306、3.501,95%可信区间为1.013-4.915、1.035-5.746、1.006-6.213、2.076-8.528,P<0.05)。 结论心脏MANEC由腺癌和神经内分泌癌两部分组成,两部分占30%以上。神经内分泌癌区肿瘤呈实巢状、玫瑰花状或器官样,核浆比高,染色质细,易见有丝分裂象。腺癌的成分有管状腺癌、粘液腺癌、乳头状腺癌等多种分化。腺癌和神经内分泌癌的成分可以交叉混合,也可以紧密相邻但不混淆。肿瘤病理TNM分期Ⅲ-Ⅳ、淋巴结转移阳性、微卫星稳定、神经内分泌癌为主要组织学分型是影响心脏MANEC患者预后的独立危险因素。关键词:神经内分泌肿瘤;混合性腺神经内分泌癌;临床病理的特点;预后;分析
{"title":"Clinicopathological characteristics and prognostic factors of cardial mixed adenoneuroendocrine carcinoma","authors":"Yangyang Sun, L. Qian, W. Gu, Gengfang Wang, Wei Gao, X. Geng, Xudong Zhang, Xiaoli Zhou","doi":"10.3760/CMA.J.ISSN.1673-9752.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2019.12.013","url":null,"abstract":"Objective \u0000To investigate the clinicopathological characteristics of cardial mixed adenoneuroendocrine carcinoma (MANEC) and analyze its prognostic factors. \u0000 \u0000 \u0000Methods \u0000The retrospective and descriptive study was conducted. The clinicopathological data of 34 patients with primary cardial MANEC who were admitted to the Changzhou No.2 People′s Hospital of Nangjing Medical University from January 2008 to January 2018 were collected. There were 20 males and 14 females, aged from 39 to 81 years, with an average age of 66 years. All the 34 patients underwent resection of cardia cancer and postoperative pathological examination. Observation indicators: (1) surgery and treatment; (2) clinical manifestations and pathological conditions; (3) pathological examination of surgical resection specimens; (4) follow-up and survival; (5) analysis of prognostic factors. Follow-up using outpatient examination and telephone interview was conducted to detect the survival of patients and tumor recurrence and metastasis up to December 2018. Measurement data with normal distribution were represented as Mean±SD. Measurement data with skewed distribution were expressed as M (range). Count data were expressed as absolute numbers or percentages. Kaplan-Merier method was used to calculate the survival time and rate and draw the survival curve, and log-rank test was used for the survival analysis. Univariate and multivariate analyses were performed using the COX proportional risk model. \u0000 \u0000 \u0000Results \u0000(1) Surgery and treatment: all the patients underwent surgery successfully and postoperative systemic chemotherapy based on cisplatin + etoposide. (2) Clinical manifestations and pathological conditions: patients had epigastric discomfort, abdominal pain and abdominal distension as the first symptoms. Of 34 patients, number of males, cases with age ≥60 years, cases with esophageal involvement, cases with stable microsatellite, cases with higher CA19-9, cases with elevated cancer embryonic antigen, cases of tumor pathologic TNM stage Ⅲ-Ⅳ, cases with tumor diameter ≥5 cm, cases with vascular tumor emboli, cases with positive lymph node metastasis, cases with nerve invasion were 20, 29, 31, 28, 4, 3, 29, 30, 27, 30, 29, respectively. (3) Pathological examination of surgical excision specimens: the masses of patients were mainly ulcer-type, with the diameter of 3.0-8.4 cm. Of the 34 patients, 1 had tumor infiltrated into submucosa, 5 infiltrated into muscle layer, 18 infiltrated into serosal layer, and 10 infiltrated into extra-serous fibrous adipose tissues. Microscopy examination showed that all tumors were composed of two components including adenocarcinoma and neuroendocrine carcinoma, and the two components accounted for more than 30%. Among adenocarcinoma components of the 34 patients, 14 were poorly differentiated tubular adenocarcinoma, 6 were mucinous adenocarcinoma, 6 were moderately differentiated tubular adenocarcinoma, 5 were low-adhesion carcinoma, 1 was highly differe","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"18 1","pages":"1163-1170"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43361373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minutes of the tenth Chinese academic conference on digestve surgery and Tsinghua-Harvard surgery forum 第十届中国消化外科学术会议暨清华-哈佛外科论坛纪要
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.101
Lang Xia, Yulin Zhang, P. Jiang, J. Huo, Linlin Shen, Yingfen Zou, D. Tao
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引用次数: 0
Diagnosis and treatment of IgG4-related pancreatitis igg4相关性胰腺炎的诊断与治疗
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.006
Zuo-liang Shi, Z. Haitao
Immunoglobulin G (IgG)4-related pancreatitis, also named as type Ⅰ autoimmune pancreatitis, is recognized as a pancreatic manifestation of IgG4-related disease. It is very hard to differentiate it from pancreatic cancer due to similar clinical manifestations with pancreatic cancer. Diagnosis of IgG4-related pancreatitis mainly relies on pathological examination and imaging examination. Corticosteroids are the main treatment for IgG4-related pancreatitis, and the risk of relapse is still high with steroid taper or following withdrawal of steroids. Based on researches on IgG4-related pancreatitis and our clinical experience, the authors have analyzed and summarized pathogenesis, clinical manifestations, clinical diagnosis, differentiation from pancreatic cancer, clinical treatment of IgG4-related pancreatitis, and suggested that elucidation of its mechanism and induction of immunotherapy may improve its efficacy. Key words: IgG4-related pancreatitis; Diagnosis; Treatment
免疫球蛋白G (IgG)4相关性胰腺炎,又称Ⅰ型自身免疫性胰腺炎,是公认的igg4相关疾病的胰腺表现。由于临床表现与胰腺癌相似,很难与胰腺癌鉴别。igg4相关性胰腺炎的诊断主要依靠病理检查和影像学检查。糖皮质激素是igg4相关性胰腺炎的主要治疗方法,随着类固醇逐渐减少或停药,复发的风险仍然很高。笔者结合对igg4相关性胰腺炎的研究及临床经验,对igg4相关性胰腺炎的发病机制、临床表现、临床诊断、与胰腺癌的鉴别、临床治疗等进行了分析总结,认为阐明其发病机制及诱导免疫治疗可提高其疗效。关键词:igg4相关性胰腺炎;诊断;治疗
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引用次数: 0
Initial investigation of comprehensive minimally invasive surgery 综合微创手术的初步研究
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.003
Jian Xu, Jian-he Sun, Zhongyang Li, S. Pan, Dongming Li, Lu Lu, Xiao Xu, Shusen Zheng
Surgical minimally invasive techniques such as image intervention, laparoscopy, endoscopy, and assisted medical robotics have become the mainstream of minimally invasive surgery (MIS). However, the vague concept, diverse misunderstanding, and the lack of standards have led to a lot of malpractice in current MIS. Based on the analysis of the clinical situation and the domestic and foreign literatures, the authors have put forward the theory of comprehensive minimally invasive surgery (CMIS), and established the concepts of minimally invasive prevention, minimally invasive diagnosis and minimally invasive follow-up in the view of hepatobiliary surgery. The authors have proposed "three-All" principles of all personnel, all aspects and all processes, and established a comprehensive four-level criteria of outcomes, complications, time and costs for CMIS, in an attempt to provide feasible and practical concepts and standards for MIS from a clinical practice and theoretical level, with a view to standardizing minimally invasive procedures and solving the problem of MIS. Key words: Hepatobiliary diseases; Minimally invasive surgery; Comprehensive; Criterion; Standard; Malpractice; Complications; Cost
影像介入、腹腔镜、内窥镜、辅助医疗机器人等外科微创技术已成为微创外科的主流。然而,由于概念模糊、误解多样、标准缺失等原因,导致当前管理信息系统存在诸多弊端。笔者在分析临床情况和国内外文献的基础上,提出了综合微创外科理论,并从肝胆外科角度建立了微创预防、微创诊断和微创随访的概念。作者提出了全人员、全方面、全流程的“三全”原则,并建立了CMIS的综合疗效、并发症、时间、成本四级标准,试图从临床实践和理论层面为MIS提供可行、实用的理念和标准,以期规范微创手术,解决MIS的问题。关键词:肝胆疾病;微创外科;全面的;标准;标准;医疗事故;并发症;成本
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引用次数: 0
Minutes of clinical research symposium of Elite Group of Chinese Journal of Digestive Surgery 《中华消化外科杂志》精英组临床研究座谈会纪要
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.103
Yingfen Zou, J. Huo, Lang Xia, Yulin Zhang, Linlin Shen, P. Jiang, D. Tao
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引用次数: 0
Assessment of quality of life after surgery for patients with hepatic hemangioma 肝血管瘤患者术后生活质量评价
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.008
Weike Gao, C. Dai, Yong-qing Xu, Yang Zhao, X. Bu, Yang Su, Liang Zhao
Objective To evaluate the postoperative quality of life after surgery of patients with hepatic hemangioma. Methods The retrospective and descriptive study was conducted. The clinical data of 104 patients who underwent surgery for hepatic hemangioma at Shengjing Hospital of China Medical University from September 2011 to February 2017 were collected. There were 28 males and 76 females, aged (49±8)years, with a range of 27-78 years. Enucleation of hepatic hemangioma or hepatectomy was selected according to tumor location of patients. Observation indicators: (1) surgical and postoperative situations; (2) assessment of quality of life in patients; (3) assessment of quality of life in patients comorbid with other chronic digestive diseases. Measurement data with normal distribution were represented as Mean±SD, and measurement data with skewed distribution were represented as M (range). Repeated data were analyzed using repeated ANOVA. Count data were represented as absolute numbers. Results (1) Surgical and postoperative situations: of 104 patients, 67 underwent enucleation of hepatic hemangioma, 37 underwent hepatectomy. The tumor diameter, volume of intraoperative blood loss, duration of postoperative hospital stay were (10±4)cm, 200 mL (range, 10-3 000 mL), (11±5)days. Seven patients had complications, including 5 of massive abdominal ascites, 1 of abdominal infection, and 1 of pulmanory obstruction. There was no death occurred. (2) Assessment of quality of life in patients with hepatic hemangioma: the total scores of Gastrointestinal-related Quality of Life Index (GIQLI), the scores of subjective symptoms, physiological status, mental and psychological status, and social activities were 121.0±8.3, 69.2±4.1, 18.5±2.6, 19.5±1.8, and 13.8±1.4 at preoperation. The above indices were 121.9±6.9, 71.2±3.8, 17.2±2.5, 19.6±2.3, and 13.8±1.3 of 104 patients with hepatic hemangioma at one month after surgery, respectively. The above indices were 127.8±6.2, 73.2±3.6, 19.8±2.5, 20.8±2.4, and 14.1±1.0 at 6 months after surgery. There were significant differences in changing trends of above indices (F=68.4, 64.6, 71.4, 17.8, 3.3, P 0.05). The total scores of GIQLI, scores of subjective symptoms, physiological status, and mental and psychological status at 6 months after surgery showed significant differences compared with those of preoperation (t=-8.897, -9.919, -5.375, -5.024, P 0.05). The total scores of GIQLI, the scores of subjective symptoms, physiological status, mental and psychological status, and social activities at 6 months after surgery were significantly different from those at one month after surgery (t=-10.835, -6.787, -12.277, -4.560, -2.476, P 0.05) . The scores of subjective symptoms and physiological status at one month after surgery showed significant differences compared with those of preoperation (t=-2.612, 2.191, P 0.05). The total scores of GIQLI, scores of subjective symptoms, physiological status, and social activities at 6
目的评价肝血管瘤患者术后生活质量。方法采用回顾性和描述性研究。收集2011年9月至2017年2月在中国医科大学附属盛京医院行肝血管瘤手术治疗的104例患者的临床资料。男性28例,女性76例,年龄(49±8)岁,年龄27 ~ 78岁。根据患者的肿瘤部位选择肝血管瘤去核或肝切除术。观察指标:(1)手术及术后情况;(2)患者生活质量评估;(3)合并其他慢性消化系统疾病患者的生活质量评估。正态分布计量资料用Mean±SD表示,偏态分布计量资料用M(极差)表示。重复数据采用重复方差分析。计数数据以绝对数字表示。结果(1)手术及术后情况:104例患者中67例行肝血管瘤去核术,37例行肝切除术。肿瘤直径(10±4)cm,术中出血量(200 mL),术后住院时间(11±5)d。7例患者出现并发症,其中腹部大量腹水5例,腹部感染1例,肺梗阻1例。没有人员死亡。(2)肝血管瘤患者生活质量评价:术前胃肠道相关生活质量指数(GIQLI)总分、主观症状评分、生理状态评分、精神心理状态评分、社会活动评分分别为121.0±8.3、69.2±4.1、18.5±2.6、19.5±1.8、13.8±1.4。104例肝血管瘤患者术后1个月上述指标分别为121.9±6.9、71.2±3.8、17.2±2.5、19.6±2.3、13.8±1.3。术后6个月,上述指标分别为127.8±6.2、73.2±3.6、19.8±2.5、20.8±2.4、14.1±1.0。各指标变化趋势差异有统计学意义(F=68.4、64.6、71.4、17.8、3.3,P < 0.05)。术后6个月GIQLI总分、主观症状评分、生理状态评分、精神心理状态评分与术前比较差异均有统计学意义(t=-8.897、-9.919、-5.375、-5.024,P 0.05)。术后6个月GIQLI总分、主观症状评分、生理状态评分、精神心理状态评分、社会活动评分与术后1个月比较差异均有统计学意义(t=-10.835, -6.787, -12.277, -4.560, -2.476, P 0.05)。术后1个月主观症状和生理状态评分与术前比较差异有统计学意义(t=-2.612, 2.191, P 0.05)。术后6个月GIQLI总分、主观症状评分、生理状态评分、社交活动评分与术前比较差异均有统计学意义(t=-4.002, -3.441, -4.604, -3.266, P 0.05)。术后6个月GIQLI总分、主观症状评分、生理状态评分、社交活动评分与术后1个月比较差异有统计学意义(t=-4.819, -2.313, -7.081, -3.172, P < 0.05)。结论肝血管瘤手术治疗可提高患者的生活质量。对于合并其他消化系统疾病的患者,手术治疗对于改善GIQLI总分、主观症状评分、生理状态评分和社交活动评分仍然有效。关键词:肝血管瘤;手术;肝血管瘤去核术;肝切除术;生活质量
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引用次数: 0
Application value of CT/MRI examination in clinical diagnosis and treatment of Crohn′s disease CT/MRI检查在克罗恩病临床诊治中的应用价值
Q4 Medicine Pub Date : 2019-12-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.12.004
Zhu Weiming, Wu Enhao, Guo-zhi Zhen
Accurate evaluation of Crohn′s disease is critical for determination of a therapeutic plan. Computed tomography (CT)/magnetic resonance imaging (MRI) can not only display the intraluminal and intraperitoneal inflammation objectively, but also reveal accurately the affected mesentery and related complications comprehensively, which attracted more and more attention in recent years. This review discussed the choice of CT/MRI examination methods, their roles in determining the severity of intestinal and mesenteric inflammation, the nature of intestinal stenosis, the extent of fistula, abscess and cellulitis, and the value in diagnosing postoperative complications, in order to investigate the application value of CT/MRI examination in clinical diagnosis and treatment of Crohn′s disease. Key words: Crohn′s disease; Computed tomography; Magnetic resonance imaging; Clinical diagnosis; Clinical treatment
准确评估克罗恩病是确定治疗计划的关键。计算机断层扫描(CT)/磁共振成像(MRI)不仅可以客观地显示腔内和腹腔内炎症,而且可以全面准确地显示受累肠系膜及相关并发症,近年来越来越受到重视。本文就CT/MRI检查方法的选择、在确定肠、肠系膜炎症严重程度、肠狭窄性质、瘘、脓肿、蜂窝织炎程度中的作用以及在诊断术后并发症中的价值进行综述,探讨CT/MRI检查在克罗恩病临床诊治中的应用价值。关键词:克罗恩病;计算机断层扫描;磁共振成像;临床诊断;临床治疗
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引用次数: 0
Diagnosis and treatment of acute incomplete intestinal obstruction caused by congenital diaphragmatic hernia incarceration 先天性膈疝嵌顿致急性不完全性肠梗阻的诊治
Q4 Medicine Pub Date : 2019-11-20 DOI: 10.3760/CMA.J.ISSN.1673-9752.2019.11.015
Jingrui Wang, Bei Lu
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引用次数: 0
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中华消化外科杂志
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