<p>As a novice researcher, I worked with a cardiology professor who was driven by clinical evidence. Clinical trials were his bread and butter, and leading guideline writing groups became his passion. The most memorable take-home message for me was this: Before you do any test, a clinician should ask themselves, ‘Will this change management? And if so, how?’ A clinician should know what they will do if the test is positive or negative and be able to articulate that. Sadly, this is not always the case. And whilst it might be ‘nice to know’, the cost of confirmatory tests is certainly not insignificant.</p><p>When I trained in ultrasound, we still called it ‘diagnostic ultrasound’ to differentiate it from therapeutic ultrasound, but this also highlighted the immense and unique diagnostic properties of ultrasound. Increasingly, ultrasound is used to not only diagnose, but also to monitor and screen for conditions, as well as to aid in management and prognosis. While all of these are laudable uses, I still think it is helpful when we can link our imaging directly to change in management.</p><p>In this issue of AJUM, Smith and Mistry<span><sup>1</sup></span> present research documenting the impact of formal echocardiography (echo) on patient management in a small clinical audit of formal echos in their intensive care unit (ICU). Although half of the patients had critical findings found on formal echo, only 25% resulted in management change. Perhaps, the remainder of the critical findings were either already suspected, and therefore being treated; or had been anticipated. Indeed, it is possible that a point of care ultrasound (POCUS) had already given them some clinical cues, and thus, the formal echo was simply confirmatory. In a reasonable number of patients, the formal echo helped make the decision to proceed with palliation and this seems an entirely reasonable reason to do an extra imaging test.</p><p>Also, in the ICU setting, Xin <i>et al</i>.<span><sup>2</sup></span> report on the use of Tissue Doppler Imaging (TDI) of the diaphragm to optimise the timing of weaning from mechanical ventilation in ICU patients. Using TDI to measure the low velocity motion of heart muscle is fundamental to echocardiography, so the extension to the diaphragm seems a logical extension of practice. But a good idea still needs to be tested and shown to aid patient management. Innovation needs to be effective.</p><p>Innovation is a key part of medicine, and finding new applications for imaging is part of that. Lau <i>et al</i>.<span><sup>3</sup></span> applied shear wave elastography to patients in a case–control study comparing patients with COVID-19 with controls and found that patients with recent (<6 months) COVID-19 had increased liver stiffness. They were prompted to do the study after observing elevated liver enzymes in these patients. But as the authors point out, these may be transient changes, and data are needed to see whether these abnormalities are asso
作为一名研究新手,我曾与一位以临床证据为动力的心脏病学教授共事。临床试验是他的面包和黄油,而领导指南编写小组则是他的激情所在。他给我留下的最深刻的启示是这样的:在做任何试验之前,临床医生都应该问自己:'这会改变管理吗?如果会,如何改变?临床医生应该知道,如果检测结果呈阳性或阴性,他们会怎么做,并能清楚地表达出来。遗憾的是,情况并非总是如此。在我接受超声波培训时,我们仍称其为 "诊断性超声波",以区别于治疗性超声波,但这也凸显了超声波巨大而独特的诊断特性。越来越多的超声波不仅用于诊断,还用于监测和筛查疾病,以及辅助管理和预后。在本期的《AJUM》杂志上,Smith 和 Mistry1 介绍了一项研究,该研究记录了正规超声心动图(echo)对重症监护病房(ICU)正规超声检查的影响。虽然半数患者在正式回波检查中发现了危急病症,但只有 25% 的患者改变了治疗方案。也许,其余的重要发现要么是已经被怀疑,因此正在接受治疗;要么是早有预料。事实上,护理点超声检查(POCUS)可能已经给了他们一些临床线索,因此,正式回波检查只是确认而已。在一定数量的患者中,正式回声有助于做出继续姑息治疗的决定,这似乎是进行额外成像检测的一个完全合理的理由。此外,在重症监护病房环境中,Xin 等人2 报告了使用横膈膜组织多普勒成像(TDI)优化重症监护病房患者机械通气断流时机的情况。使用 TDI 测量心肌的低速运动是超声心动图的基础,因此扩展到膈肌似乎是顺理成章的做法。但是,一个好的想法仍然需要经过测试,并证明它能帮助患者进行管理。创新是医学的重要组成部分,而为成像技术寻找新的应用领域也是创新的一部分。刘(Lau)等人3在一项病例对照研究中对COVID-19患者和对照组患者进行了剪切波弹性成像比较,发现近期(6个月)COVID-19患者的肝脏硬度增加。他们是在观察到这些患者肝酶升高后才进行这项研究的。但正如作者所指出的,这些可能只是短暂的变化,还需要数据来确定这些异常是否与持续性肝损伤有关。关于肝脏的超声评估,衰减成像(ATI)是一种相对较新的超声技术,可对衰减进行定量评估,有助于评估肝脂肪变性或脂肪肝。Tan 等人4 介绍了他们对在同一天接受超声检查和肝活检的患者的数据,并得出结论:虽然 ATI 与脂肪变性的组织学分级密切相关,但放射科医生的定性印象实际上是组织学结果的最佳相关性。这是一个 ATI 无助于诊断的例子,同时也引出了一个问题:如果这些患者仍然要做肝活检,那么在超声检查中增加 ATI 真的有意义吗?这个问题的答案就是证据。当我开始超声波之旅的时候,诊断心脏瓣膜疾病的金标准是有创心导管检查。但是,具有前瞻性思维的临床科学家进行的创新研究提供了证据,因此超声心动图现在已成为量化心脏瓣膜疾病的黄金标准。虽然我认为我们为超声波找到了新的临床应用并使用了正在开发的新技术,但正如这些论文所做的那样,我们必须衡量这些技术的临床效果,这一点非常重要。如果新技术不能增加临床价值,我们就必须放弃,事实上,有些技术可能会造成伤害。成像技术为患者带来的额外临床益处应该是显而易见的,成像技术不应该被常规用作另一种确诊或安慰性检查。当然,在某些情况下,后者在临床上是完全合适的。探索新兴超声技术的临床应用具有重要作用;然而,正如这些论文所显示的,研究应包括这些技术作为独立检查的临床有效性,而不仅仅是确认性的保证。
{"title":"The impact of ultrasound imaging on patient management – Let's practice the evidence","authors":"Gillian Whalley","doi":"10.1002/ajum.12412","DOIUrl":"https://doi.org/10.1002/ajum.12412","url":null,"abstract":"<p>As a novice researcher, I worked with a cardiology professor who was driven by clinical evidence. Clinical trials were his bread and butter, and leading guideline writing groups became his passion. The most memorable take-home message for me was this: Before you do any test, a clinician should ask themselves, ‘Will this change management? And if so, how?’ A clinician should know what they will do if the test is positive or negative and be able to articulate that. Sadly, this is not always the case. And whilst it might be ‘nice to know’, the cost of confirmatory tests is certainly not insignificant.</p><p>When I trained in ultrasound, we still called it ‘diagnostic ultrasound’ to differentiate it from therapeutic ultrasound, but this also highlighted the immense and unique diagnostic properties of ultrasound. Increasingly, ultrasound is used to not only diagnose, but also to monitor and screen for conditions, as well as to aid in management and prognosis. While all of these are laudable uses, I still think it is helpful when we can link our imaging directly to change in management.</p><p>In this issue of AJUM, Smith and Mistry<span><sup>1</sup></span> present research documenting the impact of formal echocardiography (echo) on patient management in a small clinical audit of formal echos in their intensive care unit (ICU). Although half of the patients had critical findings found on formal echo, only 25% resulted in management change. Perhaps, the remainder of the critical findings were either already suspected, and therefore being treated; or had been anticipated. Indeed, it is possible that a point of care ultrasound (POCUS) had already given them some clinical cues, and thus, the formal echo was simply confirmatory. In a reasonable number of patients, the formal echo helped make the decision to proceed with palliation and this seems an entirely reasonable reason to do an extra imaging test.</p><p>Also, in the ICU setting, Xin <i>et al</i>.<span><sup>2</sup></span> report on the use of Tissue Doppler Imaging (TDI) of the diaphragm to optimise the timing of weaning from mechanical ventilation in ICU patients. Using TDI to measure the low velocity motion of heart muscle is fundamental to echocardiography, so the extension to the diaphragm seems a logical extension of practice. But a good idea still needs to be tested and shown to aid patient management. Innovation needs to be effective.</p><p>Innovation is a key part of medicine, and finding new applications for imaging is part of that. Lau <i>et al</i>.<span><sup>3</sup></span> applied shear wave elastography to patients in a case–control study comparing patients with COVID-19 with controls and found that patients with recent (<6 months) COVID-19 had increased liver stiffness. They were prompted to do the study after observing elevated liver enzymes in these patients. But as the authors point out, these may be transient changes, and data are needed to see whether these abnormalities are asso","PeriodicalId":36517,"journal":{"name":"Australasian Journal of Ultrasound in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajum.12412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Zanfini, Agata Katia Patanella, Francesco Vassalli, S. Catarci, Marika Pane, L. Frassanito, M. Biancone, Mariangela Di Muro, Chiara Bravetti, Eugenio Maria Mercuri, Mario Sabatelli, G. Draisci
Nusinersen, the first treatment approved for all spinal muscular atrophy (SMA) types, is administered intrathecally through lumbar puncture. We used ultrasound assistance or a landmark‐based technique to access the lumbar intrathecal space in adult SMA patients. This study aimed to evaluate the technical success and adverse events (AEs) in such patients using either technique over a long observation period.Fifty‐one adult patients received 507 consecutive interlaminar nusinersen administrations. Patients presented with both ‘uncomplicated spines’ or ‘complicated spines’; two patients had previous back surgery. Technical success and AEs were recorded using either technique. A generalised linear mixed model was applied to evaluate predictors of technical success and complications.An overall success rate of 99.6%, with only two procedures failing to reach the intrathecal space, and an overall optimal procedure rate of 90.3% have been reported. A total of 455 procedures (89.7%) were uneventfully performed. One (0.2%) case of severe AE (puncture of a bulky abdominal annexal cyst) was recorded. Twenty‐seven episodes (5.3%) of post‐dural puncture headache (PDPH) and 24 episodes (4.7%) of radicular or back pain, both successfully treated with medical therapy, have also been reported. Technical success was significantly associated with ‘complicated spines’ (P = 0.022) and the use of ultrasound assistance (P = 0.01), and the use of ultrasound was the only independent predictor of uncomplicated procedures (P = 0.007).In adult patients with SMA both landmark‐based and ultrasound‐assisted techniques are safe and effective even in the long term. The use of assistance is associated with technical success and can predict uncomplicated procedures.Our results support the use of ultrasonography in order to improve the success and reduce the burden of nusinersen intrathecal administration.
{"title":"Ultrasound‐assisted and landmark‐based nusinersen delivery in spinal muscular atrophy adults: A retrospective analysis","authors":"B. Zanfini, Agata Katia Patanella, Francesco Vassalli, S. Catarci, Marika Pane, L. Frassanito, M. Biancone, Mariangela Di Muro, Chiara Bravetti, Eugenio Maria Mercuri, Mario Sabatelli, G. Draisci","doi":"10.1002/ajum.12401","DOIUrl":"https://doi.org/10.1002/ajum.12401","url":null,"abstract":"Nusinersen, the first treatment approved for all spinal muscular atrophy (SMA) types, is administered intrathecally through lumbar puncture. We used ultrasound assistance or a landmark‐based technique to access the lumbar intrathecal space in adult SMA patients. This study aimed to evaluate the technical success and adverse events (AEs) in such patients using either technique over a long observation period.Fifty‐one adult patients received 507 consecutive interlaminar nusinersen administrations. Patients presented with both ‘uncomplicated spines’ or ‘complicated spines’; two patients had previous back surgery. Technical success and AEs were recorded using either technique. A generalised linear mixed model was applied to evaluate predictors of technical success and complications.An overall success rate of 99.6%, with only two procedures failing to reach the intrathecal space, and an overall optimal procedure rate of 90.3% have been reported. A total of 455 procedures (89.7%) were uneventfully performed. One (0.2%) case of severe AE (puncture of a bulky abdominal annexal cyst) was recorded. Twenty‐seven episodes (5.3%) of post‐dural puncture headache (PDPH) and 24 episodes (4.7%) of radicular or back pain, both successfully treated with medical therapy, have also been reported. Technical success was significantly associated with ‘complicated spines’ (P = 0.022) and the use of ultrasound assistance (P = 0.01), and the use of ultrasound was the only independent predictor of uncomplicated procedures (P = 0.007).In adult patients with SMA both landmark‐based and ultrasound‐assisted techniques are safe and effective even in the long term. The use of assistance is associated with technical success and can predict uncomplicated procedures.Our results support the use of ultrasonography in order to improve the success and reduce the burden of nusinersen intrathecal administration.","PeriodicalId":36517,"journal":{"name":"Australasian Journal of Ultrasound in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. J. Rodríguez‐Cuadrado, G. Roustan-Gullón, F. Alfageme‐Roldán
Although the diagnosis of tinea capitis is mainly microbiological, the risk of evolution towards cicatricial alopecia in the most severe cases requires empirical treatment based on physical examination and complementary examinations.Two patients were evaluated by physical examination, cutaneous ultrasound and microbiological examination.Ultrasound showed follicular widening and increased vascularization in Doppler mode. In one of them, the finding of severe inflammatory activity led to the indication of oral corticotherapy.Cutaneous ultrasound could play a role not only in supporting the clinical diagnosis but that it may even guide the indication of treatment in the presence of severe inflammation that sometimes may not manifest itself clinically.Cutaneous ultrasound may constitute an additional test of considerable usefulness in the diagnosis and evaluation of inflammatory activity in cases such as the ones presented, fast, non‐invasive and of high accessibility.
{"title":"Cutaneous ultrasound in the diagnosis and assessment of inflammatory activity in tinea capitis","authors":"F. J. Rodríguez‐Cuadrado, G. Roustan-Gullón, F. Alfageme‐Roldán","doi":"10.1002/ajum.12402","DOIUrl":"https://doi.org/10.1002/ajum.12402","url":null,"abstract":"Although the diagnosis of tinea capitis is mainly microbiological, the risk of evolution towards cicatricial alopecia in the most severe cases requires empirical treatment based on physical examination and complementary examinations.Two patients were evaluated by physical examination, cutaneous ultrasound and microbiological examination.Ultrasound showed follicular widening and increased vascularization in Doppler mode. In one of them, the finding of severe inflammatory activity led to the indication of oral corticotherapy.Cutaneous ultrasound could play a role not only in supporting the clinical diagnosis but that it may even guide the indication of treatment in the presence of severe inflammation that sometimes may not manifest itself clinically.Cutaneous ultrasound may constitute an additional test of considerable usefulness in the diagnosis and evaluation of inflammatory activity in cases such as the ones presented, fast, non‐invasive and of high accessibility.","PeriodicalId":36517,"journal":{"name":"Australasian Journal of Ultrasound in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}