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Hepatic steatosis: Qualitative and quantitative sonographic assessment in comparison to histology 肝脏脂肪变性:超声定性和定量评估与组织学比较
Q3 Medicine Pub Date : 2024-04-25 DOI: 10.1002/ajum.12381
Zhi Xin Tan, Bryan Mehta, Kieran Kusel, James Seow, Marilyn Zelesco, Steven Abbott, Rebecca Simons, Glenn Boardman, Christopher J. Welman, Oyekoya T. Ayonrinde

Introduction

Globally, B-mode ultrasound is the most common modality used for the diagnosis of hepatic steatosis. We aimed to assess the correlation between qualitative liver ultrasound parameters, attenuation imaging (ATI) and histopathology-diagnosed steatosis grade obtained from liver biopsy. Our secondary aim was to examine the interobserver variability of qualitative ultrasound features.

Methods

A retrospective cohort study was performed which included adult patients (age ≥ 18 years) who had same-day liver ultrasound, ATI and liver biopsy for grading hepatic steatosis severity between 2018 and 2022. The qualitative US features for hepatic steatosis were independently scored by three radiologists and interobserver variability was examined. Histologic steatosis grade, ATI and qualitative ultrasound parameters were compared.

Results

Ninety patients were included; 67% female with a median age of 54 (IQR 39–65) years. The radiologist's overall impression had the highest correlation (very strongly correlated) with histologic steatosis grade (r = 0.82, P < 0.001). ATI coefficient and all qualitative ultrasound B-mode features except for liver echotexture and focal fat sparing were strongly correlated with histologic steatosis grade (r ≥ 0.70, P < 0.001). Most qualitative ultrasound features had good agreement between observers (Kappa statistic 0.61–1.0, P < 0.001), (Kendall coefficient 0.92, P < 0.001).

Conclusion

The examined qualitative ultrasound parameters and ATI had good-excellent performance for diagnosing clinically significant hepatic steatosis; however, the radiologist's overall impression had the best correlation with histologic steatosis grade. Our findings suggest an ongoing role for qualitative liver ultrasound assessment of hepatic steatosis despite the emergence of newer quantitative measures.

导言 在全球范围内,B 型超声是诊断肝脂肪变性最常用的方法。我们的目的是评估肝脏超声定性参数、衰减成像(ATI)和肝活检组织病理学诊断脂肪变性等级之间的相关性。我们的第二个目的是检查定性超声特征的观察者间变异性。 方法 我们开展了一项回顾性队列研究,纳入了 2018 年至 2022 年间接受过当天肝脏超声、ATI 和肝活检以对肝脏脂肪变性严重程度进行分级的成年患者(年龄≥ 18 岁)。肝脏脂肪变性的定性 US 特征由三名放射科医师独立评分,并考察观察者之间的差异性。比较了组织学脂肪变性分级、ATI和定性超声参数。 结果 共纳入 90 名患者;67% 为女性,中位年龄为 54(IQR 39-65)岁。放射科医生的总体印象与组织学脂肪变性等级的相关性最高(非常相关)(r = 0.82,P < 0.001)。除了肝脏回声纹理和局灶脂肪疏松外,ATI系数和所有定性超声B型特征都与组织学脂肪变性分级密切相关(r≥0.70,P <0.001)。大多数定性超声特征在观察者之间具有良好的一致性(Kappa 统计量 0.61-1.0,P < 0.001),(Kendall 系数 0.92,P < 0.001)。 结论 所研究的定性超声参数和 ATI 在诊断临床上显著的肝脂肪变性方面表现良好,但放射科医生的总体印象与组织学脂肪变性分级的相关性最好。我们的研究结果表明,尽管出现了更新的定量评估方法,但肝脏超声定性评估肝脂肪变性的作用仍在继续。
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引用次数: 0
Comparison of ultrasound guidance with landmark guidance for symptomatic benefits in knee, hip and hand osteoarthritis: Systematic review and meta-analysis of randomised controlled trials 比较超声引导与地标引导对膝关节、髋关节和手部骨关节炎症状的益处:随机对照试验的系统回顾和荟萃分析
Q3 Medicine Pub Date : 2024-04-19 DOI: 10.1002/ajum.12386
Win Min Oo, James Linklater, Md Abu Bakar Siddiq, Kai Fu, David J. Hunter

Introduction

More than half of the patients with moderate and severe osteoarthritis (OA) report unsatisfactory pain relief, requiring consideration of intra-articular (IA) injections as the second-line management. Ultrasound-guided IA injection has proven evidence of higher accuracy in administering IA injectates into the joints than landmark-guided or blind IA injections. However, questions remain about translating higher accuracy rates of ultrasound-guided injection into better clinical improvements. Therefore, we examined the symptomatic benefits (pain, function and patient satisfaction) of ultrasound-guided injection in knee, hip and hand OA compared with blind injections by synthesising a systematic review and meta-analysis of randomised controlled trials (RCT).

Methods

PubMed, Medline and Embase databases were searched for eligible studies from their inception to August 28, 2023.

Results

Out of 295 records, our meta-analysis included four RCTs (338 patients with knee OA), demonstrating significant improvement in procedural pain [−0.89 (95% CI −1.25, −0.53)], pain at follow-up [−0.51 (95% CI −0.98, −0.04)] and function [1.30 (95% CI 0.86, 1.73)], favouring ultrasound guidance. One single study showed higher patient satisfaction with ultrasound guidance.

Conclusion

Ultrasound-guided IA injection provided superior clinical outcomes compared with landmark-guided IA injection.

一半以上的中度和重度骨关节炎(OA)患者对疼痛缓解效果不满意,需要考虑将关节腔内注射(IA)作为二线治疗方法。有证据表明,超声引导下的关节腔内注射比地标引导下或盲目的关节腔内注射更准确。然而,如何将超声引导注射的更高准确率转化为更好的临床疗效仍是一个问题。因此,我们通过对随机对照试验(RCT)进行系统综述和荟萃分析,研究了超声引导注射与盲法注射相比对膝关节、髋关节和手部OA症状的益处(疼痛、功能和患者满意度)。在295条记录中,我们的荟萃分析包括了四项随机对照试验(338名膝关节OA患者),结果表明超声引导可显著改善手术疼痛[-0.89 (95% CI -1.25, -0.53)]、随访疼痛[-0.51 (95% CI -0.98, -0.04)]和功能[1.30 (95% CI 0.86, 1.73)]。与地标引导的 IA 注射相比,超声引导的 IA 注射能提供更好的临床效果。
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引用次数: 0
Ultrasound assessment of acute Achilles tendon rupture and measurement of the tendon gap 跟腱急性断裂的超声评估和肌腱间隙的测量
Q3 Medicine Pub Date : 2024-04-17 DOI: 10.1002/ajum.12384
Michelle Fenech, Aiyapa Ajjikuttira, Heath Edwards

Achilles tendon rupture is a common sports-related injury which can carry significant morbidity to patients. Ultrasound remains the workhorse of imaging as it can confirm and localise the extent of Achilles tendon injury. The sonographic anatomy, both normal and ruptured sonographic appearances, as well as sonographic technique must be appreciated to accurately image and report findings, critical to patient management. Particular attention should be applied to the measurement of the diastasis between acutely ruptured tendon ends as this information can assist with informing the decision of conservative vs. operative management. Further work is necessary to standardise the measurement technique including correlating the degree of plantarflexion of the foot with the sonographic tendon gap measures.

跟腱断裂是一种常见的运动相关损伤,会给患者带来严重的发病率。超声波仍是成像的主力,因为它可以确认和定位跟腱损伤的程度。必须了解声像解剖学,包括正常和断裂的声像表现,以及声像技术,才能准确成像和报告结果,这对患者管理至关重要。应特别注意测量急性断裂肌腱末端之间的间隙,因为该信息有助于决定保守治疗还是手术治疗。有必要进一步规范测量技术,包括将足部跖屈程度与声学肌腱间隙测量结果联系起来。
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引用次数: 0
Efficacy and histologic frequencies of endoscopic ultrasonography-guided tissue acquisition using conventional fine-needle aspiration needles for gastric subepithelial hypoechoic mass 使用传统细针抽吸针在内镜超声引导下采集组织治疗胃上皮下低回声肿块的疗效和组织学频率
Q3 Medicine Pub Date : 2024-04-15 DOI: 10.1002/ajum.12382
Kazuya Akahoshi, Shinichi Tamura, Kazuaki Akahoshi, Yuki Shiratsuchi, Hidenobu Koga, Masafumi Oya, Yoshihiro Ohishi, Tadashi Koga

Introduction/Purpose

For gastric subepithelial lesions (GSELs) showing a hypoechoic mass (HM) on endoscopic ultrasonography (EUS) imaging, the utility of EUS-guided tissue acquisition using conventional fine-needle aspiration needles (EUS-TA-CFNAN) and the frequency of histological types remain unclear. This study aimed to examine this issue.

Methods

This prospective observational study enrolled 291 consecutive patients who underwent EUS-TA-CFNAN for GSELs showing an HM (GSELHM) on EUS imaging. Immunohistochemical analysis was performed for all EUS-TA-CFNAN and surgically resected specimens. The main outcome measures were the technical results of EUS-TA-CFNAN and the frequency of histological types in GSELHM.

Results

The endoscopic ultrasound-guided tissue acquisition using conventional fine-needle aspiration needle diagnosis rate for GSELHM was 80.1% (95% confidence interval [CI]: 75.0–84.5, 233/291). It was significantly lower for antrum (P = 0.004) and lesions smaller than 2 cm (P = 0.003). There were no adverse events. The immunohistochemical diagnoses of EUS-TA-CFNAN included 149 cases of gastrointestinal stromal tumour (GIST) (51.2%), 48 cases of leiomyoma (16.5%), 11 cases of schwannoma (3.8%), 8 cases of the ectopic pancreas (2.7%), 5 cases of subepithelial lesion like cancer (1.7%), 12 cases of other lesions (4.1%), and 58 cases of undiagnosable lesions (19.9%). The frequency of malignant or potentially malignant tumour in GSELHM was 55.0% (95% CI: 49.1–60.8, 160/291). Surgery was performed in 149 patients according to the conclusive EUS-TA-CFNAN results, in which the diagnostic accuracy of EUS-TA-CFNAN was 97.3% (95% CI: 94.7–99.9, 145/149).

Conclusion

The use of EUS-TA-CFNAN for GSELHMs is safe and accurate. Gastric subepithelial lesions showing a hypoechoic mass have a reasonably high possibility of containing malignant or potentially malignant tumours, including GISTs.

对于内镜超声成像(EUS)显示低回声肿块(HM)的胃上皮下病变(GSELs),在 EUS 引导下使用传统细针穿刺针采集组织(EUS-TA-CFNAN)的效用和组织学类型的频率仍不清楚。这项前瞻性观察研究连续纳入了 291 例接受 EUS-TA-CFNAN 治疗的患者,这些患者的 GSEL 在 EUS 成像中显示为 HM(GSELHM)。对所有 EUS-TA-CFNAN 和手术切除标本进行了免疫组化分析。主要结果指标为 EUS-TA-CFNAN 的技术结果和 GSELHM 的组织学类型频率。在内镜超声引导下,使用常规细针穿刺针采集组织的 GSELHM 诊断率为 80.1%(95% 置信区间 [CI]:75.0-84.5,233/291)。胃窦部(P = 0.004)和小于 2 厘米的病灶(P = 0.003)的诊断率明显较低。无不良反应。EUS-TA-CFNAN 的免疫组化诊断包括胃肠道间质瘤(GIST)149 例(51.2%)、子宫肌瘤 48 例(16.5%)、裂瘤 11 例(3.8%)、异位胰腺 8 例(2.7%)、上皮下病变(如癌症)5 例(1.7%)、其他病变 12 例(4.1%)和无法诊断的病变 58 例(19.9%)。在 GSELHM 中,恶性或潜在恶性肿瘤的发生率为 55.0%(95% CI:49.1-60.8,160/291)。149例患者根据EUS-TA-CFNAN的确诊结果进行了手术,其中EUS-TA-CFNAN的诊断准确率为97.3%(95% CI:94.7-99.9,145/149)。显示低回声肿块的胃上皮下病变含有恶性或潜在恶性肿瘤(包括 GIST)的可能性相当高。
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引用次数: 0
Correction to ‘Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography’ 回顾:使用经颅多普勒或标准超声心动图检测卵圆孔未闭
Q3 Medicine Pub Date : 2024-03-27 DOI: 10.1002/ajum.12380

Van der Giessen, H., Wilson, L.C., Coffey, S. and Whalley, G.A. (2020). Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography. Australasian Journal of Ultrasound in Medicine 23: 210–219. https://doi.org/10.1002/ajum.12232

The article title should be ‘Review: Detection of patent foramen ovale using transcranial Doppler or standard echocardiography’.

Van der Giessen, H., Wilson, L.C., Coffey, S. and Whalley, G.A. (2020).回顾:使用经颅多普勒或标准超声心动图检测患者卵圆孔。Australasian Journal of Ultrasound in Medicine 23: 210-219。https://doi.org/10.1002/ajum.12232The,文章标题应为 "Review:使用经颅多普勒或标准超声心动图检测患者卵圆孔"。
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引用次数: 0
The ‘onion skin’ sign of a low-grade appendiceal mucinous neoplasm: An incidental finding during early pregnancy assessment 低级别阑尾粘液瘤的 "洋葱皮 "征:早孕评估中的偶然发现
Q3 Medicine Pub Date : 2024-03-12 DOI: 10.1002/ajum.12377
Hanine Fourie, Maya Al Memar, Maeve Tuomey, Catriona Stalder, Paul Ziprin, Tom Bourne

A low-grade appendiceal mucinous neoplasm (LAMN) is a cystic dilatation of the appendix resulting from the accumulation of mucinous secretions caused by a luminal obstruction. Although usually benign, pseudomyxoma peritonei may occur in the event of rupture, and 10% of cases may be secondary to appendiceal cystadenocarcinoma. A LAMN is both more common and more likely to have a malignant association in women, making it an entity with which practitioners of gynaecological ultrasound should be familiar. Although not the primary aim, early pregnancy ultrasound assessments can offer the diagnostic opportunity to identify pelvic pathology. A LAMN can be identified on ultrasonography by visualisation of an adnexal mass separate to the ovary, which due to the layers of secretions has a distinctive appearance previously likened to ‘onion-skin’ or ‘whipped-cream’. Here, we describe an incidental finding of a LAMN during an early pregnancy assessment. Practitioners of early pregnancy ultrasound should be familiar with the characteristic morphology of this rare but important finding.

低度阑尾粘液瘤(LAMN)是由于管腔阻塞导致粘液性分泌物积聚而形成的阑尾囊性扩张。虽然通常是良性的,但在破裂时可能会发生腹膜假性肌瘤,10%的病例可能继发于阑尾囊腺癌。LAMN 在女性中更常见,也更有可能与恶性肿瘤有关,因此妇科超声从业者应该熟悉这种疾病。孕早期超声评估虽然不是主要目的,但它能为盆腔病变提供诊断机会。LAMN 可通过超声波检查发现与卵巢分离的附件肿块,该肿块因其分泌物层而具有独特的外观,以前曾被比喻为 "洋葱皮 "或 "奶油"。在此,我们描述了在一次早孕评估中偶然发现的 LAMN。从事孕早期超声检查的医生应该熟悉这种罕见但重要的发现的特征形态。
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引用次数: 0
Is research one of your New Year's resolutions? 研究是您的新年愿望之一吗?
Q3 Medicine Pub Date : 2024-02-29 DOI: 10.1002/ajum.12378
Gillian Whalley

I am reflecting on my own plans for 2024, and research is definitely on my ‘resolution list’, is it on yours? Perhaps you are thinking of enrolling in a higher research degree? Or you have an idea for a project you've been wanting to get off the ground? Maybe you are sitting on a database that is just waiting to be transformed into a paper that has the potential to explain, inform or, indeed, change practice? If any of these resonate with you, then I encourage you to begin your next, or indeed first, research project.

Every research project starts with a research question, but the methods used vary depending on that question. The study design and approach will be defined by the question, and it is important to remember that there is no one way to undertake ultrasound research. There are many different study approaches: from audits and educational research to outcomes research.

All research starts with data. In this issue of AJUM, Moore et al.1 take you through the steps needed to mine data from an imaging archive. Most of us have a digital database of images, measurements and reports, but extracting those data in a consistent way, especially when there are free text fields, is not as straightforward as one would think.

When little is known about a condition, research often takes the form of clinical audit of cases or case series. We have three distinct examples of this in this AJUM issue: Hosokawa et al.2 compare the detection of submandibular sialoliths by ultrasound with magnetic resonance imaging (MRI) and computed tomography (CT), while Boman et al.3 present a small case series demonstrating a potential role for ultrasound to detect small vessel inflammation as a pre-curser to rheumatic vasculitis. Lastly, Walsh and Lees4 present a clinical audit of over 3000 consecutive routine mid-semester obstetric scans and report the proportion of major and minor abnormalities. There are two important points to note within this study, which speak to the veracity of the data: this is a single operator clinic such that the ultrasound approach was likely consistent over the time period, and they included consecutive patients. Clinical research should be undertaken using consecutive patients, which ensures all eligible patients are recruited. When non-consecutive, or convenience, sampling is used, I often wonder why they were excluded. Because of image quality? Because their results were outliers—not aligned to the researchers' bias?

It is often said that the strongest form of evidence, after the randomised clinical trial, is meta-analysis or systematic review because all the available evidence is presented in a summative and unbiased manner. One such review by Giri et al.5 considered the data related to contrast-enhanced ultrasound for differentiation of benign and malignant portal vei

我正在思考自己 2024 年的计划,研究肯定在我的 "决议清单 "上,你的计划中也有吗?也许您正在考虑攻读更高的研究学位?或者你有一个一直想启动的项目的想法?也许你正在使用一个数据库,正等待着将其转化为一篇论文,从而有可能解释、提供信息,甚至改变实践?如果您对这些问题有任何共鸣,那么我鼓励您开始下一个或第一个研究项目。每个研究项目都始于一个研究问题,但根据问题的不同,使用的方法也各不相同。研究设计和方法将由问题决定,重要的是要记住,进行超声波研究没有唯一的方法。有许多不同的研究方法:从审计和教育研究到结果研究。在本期 AJUM 中,Moore 等人1 将带您了解从成像档案中挖掘数据所需的步骤。我们中的大多数人都有一个包含图像、测量结果和报告的数字数据库,但要以一致的方式提取这些数据,尤其是在有自由文本字段的情况下,并不像人们想象的那样简单。当人们对某种疾病知之甚少时,研究通常采取病例临床审计或病例系列的形式。在本期 AJUM 中,我们就有三个明显的例子:Hosokawa 等人2 比较了超声与磁共振成像(MRI)和计算机断层扫描(CT)对下颌下腺霰粒肿的检测;Boman 等人3 提出了一个小型病例系列,证明了超声在检测风湿性脉管炎前兆小血管炎症方面的潜在作用。最后,Walsh 和 Lees4 对连续 3000 多例常规产科中期扫描进行了临床审核,并报告了主要和次要异常的比例。这项研究有两个要点值得注意,它们说明了数据的真实性:这是一个单一操作者的诊所,因此超声检查方法在这段时间内可能是一致的,而且他们纳入了连续的患者。临床研究应使用连续患者,以确保招募到所有符合条件的患者。当使用非连续或方便取样时,我经常会想,为什么要把他们排除在外?因为图像质量?人们常说,在随机临床试验之后,最有力的证据形式是荟萃分析或系统综述,因为所有可用证据都是以总结性和无偏见的方式呈现的。Giri 等人5 的一篇此类综述研究了造影剂增强超声波用于区分肝细胞癌患者良性和恶性门静脉血栓的相关数据,并得出结论:超声波可作为 CT 或 MRI 的替代方式。与 CT 或 MRI 作为黄金标准进行比较是超声研究中经常出现的主题,这类比较对于提高超声的独立疗效非常有用:最后,本期还有两篇范围界定综述:Deslandes 等人6 对人工智能在妇科超声技师教育中的作用进行了范围界定综述调查,而 Joyce 等人7 则对急诊科急性胆囊炎的护理点超声诊断准确性进行了调查。范围综述是了解研究领域内已有研究成果的绝佳方法,可以帮助您确定自己的研究想法是否新颖。一旦有了新颖的研究问题,您就需要合作者。研究合作者可以带来不同的想法并分担工作量,他们可以是本地人、州际人或跨国人。您需要的只是对超声波成像的共同热情和一个好的研究问题。那么问题来了,您将在 2024 年开始还是继续您的研究之路?
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引用次数: 0
Sonographic features of sternal pseudotumour in children 儿童胸骨假瘤的声像图特征
Q3 Medicine Pub Date : 2024-02-06 DOI: 10.1002/ajum.12376
Samantha Gerrie, Mike Watson, Phil Morreau

Introduction

Sternal pseudotumour is an important but rare entity thought to be an inflammatory, non-neoplastic lesion that can mimic tumours. The purpose of this paper was to illustrate the imaging features of this lesion to avoid unnecessary investigations.

Methods

The clinical notes and imaging features of four patients with a diagnosis of sternal pseudotumour were reviewed over a period from February 2016 to July 2019.

Results

All patients were afebrile with no history of trauma. The median age at presentation was 12.5 months. The median length of symptoms prior to presentation was 3.5 days. One patient had a mildly elevated C-reactive protein. Chest radiographs showed a pre-sternal soft-tissue mass, with or without osseous destruction of the subjacent sternum. Ultrasound showed a heterogeneous, hypoechoic pre-sternal soft-tissue mass with variable internal vascularity with extension between sternal ossification centres. CT and MRI showed an enhancing dumbbell-shaped lesion with a pre-sternal and retro-sternal soft-tissue component. The median time to complete resolution was 3 months. One patient had a biopsy that showed chronic inflammation and fibrosis.

Discussion

These lesions present in young children typically with a 1- to 2-week history of a focal 2- to 4-cm swelling over the sternum. The aetiology is unknown but may be on the basis of a yet-to-be identified pathogen. Inflammatory markers and cultures are normal or mildly elevated. Important differential considerations include sternal osteomyelitis or neoplastic causes such as Ewing sarcoma, rhabdomyosarcoma, Langerhans cell histiocytosis and infantile fibrosarcoma.

Conclusion

Sternal pseudotumor is a rare but important entity to be aware of to avoid unnecessary invasive biopsy or further investigations. Our suggestion is that this is a ‘Don't touch’ lesion that requires close short-interval follow-up at a surgical outpatient clinic and with ultrasound until resolution.

胸骨假瘤是一种重要但罕见的病变,被认为是一种可模拟肿瘤的炎性、非肿瘤性病变。本文旨在说明这种病变的影像学特征,以避免不必要的检查。本文回顾了2016年2月至2019年7月期间诊断为胸骨假瘤的四名患者的临床笔记和影像学特征。患者发病时的中位年龄为12.5个月。发病前症状持续时间的中位数为 3.5 天。一名患者的C反应蛋白轻度升高。胸片显示胸骨前软组织肿块,伴有或不伴有胸骨下骨质破坏。超声波检查显示胸骨前软组织肿块呈异质、低回声,内部血管多变,在胸骨骨化中心之间延伸。CT和MRI显示,病变呈增强的哑铃状,有胸骨前和胸骨后软组织成分。完全缓解的中位时间为 3 个月。一名患者进行了活组织检查,结果显示存在慢性炎症和纤维化。这些病变通常发生在幼儿身上,病史为1至2周,胸骨上出现2至4厘米的局灶性肿胀。病因不明,但可能是一种尚未确定的病原体。炎症标志物和培养物正常或轻度升高。重要的鉴别考虑因素包括胸骨骨髓炎或肿瘤性病因,如尤文肉瘤、横纹肌肉瘤、朗格汉斯细胞组织细胞增生症和婴儿纤维肉瘤。我们的建议是,这是一种 "不可触碰 "的病变,需要在外科门诊进行密切的短期随访,并进行超声检查,直至病变消退。
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引用次数: 0
Use of an ultrasound picture archiving and communication system to answer research questions: Description of data cleaning methods 使用超声图片存档和通信系统回答研究问题:数据清理方法说明
Q3 Medicine Pub Date : 2024-01-13 DOI: 10.1002/ajum.12374
Matthew K Moore, Gillian Whalley, Gregory T Jones, Sean Coffey

Introduction/Purpose

Ultrasound picture archiving and communication system (PACS) databases are useful for quality improvement and clinical research but frequently contain free text that is not easily readable. Here, we present a method to extract and clean a semi-structured echocardiography (cardiac ultrasound) PACS database.

Methods

Echocardiography studies between 1 January 2010 and 31 December 2018 were extracted using a data mining tool. Numeric variables were recoded with extreme values excluded. Analysis of free text, including descriptions of the heart valves and right and left ventricular size and function, was performed using a rule-based system. Different levels of free text variables were initially identified using commonly used phrases and then iteratively developed. Randomly selected sets of 100 studies were compared to the electronic health record to validate the data cleaning process.

Results

The data validation step was performed three times in total, with Cohen's kappa ranging between 0.88 and 1.00 for the final set of data validation across all measures.

Conclusion

Free text cleaning of semi-structured PACS databases is possible using freely available open-source software. The accuracy of this method is high, and the resulting dataset can be linked to administrative data to answer research questions. We present a method that could be used to answer clinical questions or to develop quality improvement initiatives.

超声图片存档和通信系统(PACS)数据库对质量改进和临床研究非常有用,但经常包含不易阅读的自由文本。在此,我们介绍一种提取和清理半结构化超声心动图(心脏超声)PACS 数据库的方法。我们使用数据挖掘工具提取了 2010 年 1 月 1 日至 2018 年 12 月 31 日期间的超声心动图研究。对数值变量进行了重新编码,并排除了极端值。使用基于规则的系统分析自由文本,包括对心脏瓣膜和左右心室大小及功能的描述。最初使用常用短语确定不同层次的自由文本变量,然后进行反复开发。随机抽取的 100 组研究报告与电子健康记录进行对比,以验证数据清理过程。数据验证步骤共进行了三次,在所有措施的最后一组数据验证中,科恩卡帕(Cohen's kappa)介于 0.88 和 1.00 之间。使用免费提供的开源软件可以对半结构化 PACS 数据库进行自由文本清理。这种方法的准确性很高,所得到的数据集可以与行政数据相连接,从而回答研究问题。我们介绍的方法可用于回答临床问题或制定质量改进计划。
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引用次数: 0
Ultrasound imaging of the dorsalis pedis artery as an early indicator of the precursory changes for rheumatoid vasculitis: A case series 足背动脉超声成像是类风湿血管炎前兆变化的早期指标:病例系列
Q3 Medicine Pub Date : 2023-12-17 DOI: 10.1002/ajum.12373
Robyn Boman, Stefania Penkala, Rosa H. M. Chan, Fredrick Joshua, Roy Tsz Hei Cheung

Introduction

Clinical verification of rheumatoid vasculitis (RV) persists as a mid-to-late diagnosis with medical imaging or biopsy. Early and subclinical presentations of RV, in particular, can remain underdiagnosed in the absence of adequate diagnostic testing. In this study, the research demonstrated the precursory changes for RV in patients with rheumatoid arthritis (RA) using non-invasive ultrasound imaging of a peripheral vessel.

Method

Six participants were recruited: three participants with (RA) and three age- and gender-matched healthy controls. All participants completed a Foot Health Survey Questionnaire (FHSQ), and participants with RA completed a Rheumatoid Arthritis Disease Activity Index-5 (RADAI-5). Bilateral B-mode and Doppler ultrasound of the dorsalis pedis artery (DPA) was performed. The degree of inflammation, lumen and artery diameters, lumen diameter-to-artery diameter ratio and peak systolic velocity in the proximal DPA were compared between the two groups.

Results

The mean RADAI-5 score (5.4 ± 0.8 out of 10) indicated moderate disease activity amongst participants with RA. Inflammation was observed in the DPA wall in all participants with RA, compared to no inflammation observed in the control group (Friedmans two-way analysis: χ2 = 15.733, P = 0.003). Differences between groups for inflammation, lumen diameter and lumen diameter-to-artery diameter ratio were found (P < 0.034), without differences for artery diameter and peak systolic velocity (P > 0.605). DPA wall inflammation did not correlate with FHSQ scores (r = −0.770, P = 0.073).

Conclusion

Despite moderate RA disease activity, this is the first study to demonstrate the use of ultrasound to observe inflammation in small vessel disease. Our findings suggest ultrasound imaging may be a viable screening tool to demonstrate arterial wall inflammation, indicating the precursory changes of RV.

类风湿性血管炎(RV)的临床验证一直是医学影像或活检的中晚期诊断。特别是早期和亚临床表现的类风湿血管炎,在缺乏适当诊断测试的情况下,可能仍然诊断不足。在这项研究中,研究人员利用外周血管的非侵入性超声波成像技术,证明了类风湿性关节炎(RA)患者RV的前兆变化。所有参与者都填写了足部健康调查问卷(FHSQ),类风湿性关节炎患者填写了类风湿性关节炎疾病活动指数-5(RADAI-5)。对双侧足背动脉(DPA)进行了B型和多普勒超声检查。两组患者的炎症程度、管腔和动脉直径、管腔直径与动脉直径之比以及近端 DPA 收缩速度峰值进行了比较。RADAI-5 平均得分(5.4 ± 0.8,满分为 10 分)表明 RA 患者的疾病活动度为中度。所有RA患者的DPA壁均出现炎症,而对照组无炎症(Friedmans双向分析:χ2 = 15.733,P = 0.003)。炎症、管腔直径和管腔直径与动脉直径比值在组间存在差异(P 0.605)。DPA管壁炎症与FHSQ评分无相关性(r = -0.770,P = 0.073)。尽管RA疾病活动度中等,但这是第一项利用超声观察小血管疾病炎症的研究。我们的研究结果表明,超声成像可能是显示动脉壁炎症的一种可行的筛查工具,可显示RV的前兆变化。
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Australasian Journal of Ultrasound in Medicine
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