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Optical Polarization Evolution and Transmission in Multi-Ranvier-Node Axonal Myelin-Sheath Waveguides 多ranvier节点轴突髓鞘波导的光偏振演化与传输
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-19 DOI: 10.1109/TMBMC.2024.3464415
Emily Frede;Hadi Zadeh-Haghighi;Christoph Simon
In neuroscience, it is of interest to consider all possible modes of information transfer between neurons in order to fully understand processing in the brain. It has been suggested that photonic communication may be possible along axonal connections, especially through the myelin sheath as a waveguide, due to its high refractive index. There is already a good deal of theoretical and experimental evidence for light guidance in the myelin sheath; however, the question of how the polarization of light is transmitted remains largely unexplored. It is presently unclear whether polarization-encoded information could be preserved within the myelin sheath. We simulate guided mode propagation through a myelinated axon structure with multiple Ranvier nodes. This allows both to observe polarization change and to test the assumption of exponentiated transmission loss through multiple Ranvier nodes for guided light in myelin sheath waveguides. We find that the polarization can be well preserved through multiple nodes and that transmission losses through multiple nodes are approximately multiplicative. These results provide an important context for the hypothesis of neural information transmission facilitated by biophotons, strengthening the possibility of both classical and quantum photonic communication within the brain.
在神经科学中,考虑神经元之间信息传递的所有可能模式以充分理解大脑中的处理是很有兴趣的。由于髓鞘的高折射率,光子通信可能沿着轴突连接,特别是通过作为波导的髓鞘进行。已经有大量的理论和实验证据证明髓鞘中的光引导;然而,光的偏振是如何传播的问题在很大程度上仍未被探索。目前还不清楚极化编码的信息是否可以保存在髓鞘内。我们模拟引导模式传播通过有髓鞘的轴突结构与多个朗维耶节点。这既可以观察偏振变化,也可以测试在髓鞘波导中引导光通过多个朗维耶节点的指数传输损耗假设。我们发现,通过多个节点可以很好地保持极化,并且通过多个节点的传输损失近似为乘法。这些结果为生物光子促进神经信息传递的假设提供了重要的背景,加强了脑内经典和量子光子通信的可能性。
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引用次数: 0
Molecular Quantum (MolQ) Communication Channel in the Gut-Brain Axis Synapse 肠-脑轴突触中的分子量子(MolQ)通信通道
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-17 DOI: 10.1109/TMBMC.2024.3462727
Bitop Maitra;Ozgur B. Akan
The gut-brain axis is the communication link between the gut and the brain. Although it is known that the gut-brain axis plays a pivotal role in homeostasis, its overall mechanism is still not known. However, for neural synapses, classical molecular communication is described by the formation of ligand-receptor complexes, which leads to the opening of ion channels. Moreover, there are some conditions that need to be fulfilled before the opening of the ion channel. In this study, we consider the gut-brain axis, where neurotransmitters diffuse through the synaptic cleft, considering molecular communication. On the vagus nerve (VN) membrane, i.e., the post-synaptic membrane of the synapse, it undergoes a quantum communication (QC), which initiates the opening of the ion channel, thus initiating the communication signal from the gut to the brain. It evolves a new paradigm of communication approach, Molecular Quantum (MolQ) communication. Based on the QC model, we theoretically analyze the output states, and QC is simulated considering the incoming neurotransmitter’s concentration and validated by analyzing the entropy and the mutual information of the input, i.e., neurotransmitter’s concentration, and output, i.e., ion channel opening.
肠脑轴是肠和大脑之间的沟通纽带。虽然已知肠脑轴在体内平衡中起关键作用,但其整体机制尚不清楚。然而,对于神经突触来说,经典的分子通信是通过配体-受体复合物的形成来描述的,这导致离子通道的开放。此外,在离子通道打开之前还需要满足一些条件。在这项研究中,我们考虑肠-脑轴,神经递质通过突触间隙扩散,考虑分子通讯。在迷走神经(VN)膜上,即突触的突触后膜上,进行量子通信(QC),量子通信启动离子通道的打开,从而启动肠道到大脑的通信信号。它发展了一种新的通信方法范式——分子量子通信。在QC模型的基础上,从理论上分析了输出状态,考虑输入神经递质浓度对QC进行了仿真,并通过分析输入神经递质浓度和输出离子通道开度的熵和互信息进行了验证。
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引用次数: 0
The Method of Fictitious Negative Sources to Model Diffusive Channels With Absorbing Boundaries 用虚构负源法模拟有吸收边界的扩散通道
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-02 DOI: 10.1109/TMBMC.2024.3453808
Fardad Vakilipoor;Abdulhamid N. M. Ansari;Luca Barletta;Gian Guido Gentili;Maurizio Magarini
This paper presents an approach to address the diffusion equation in scenarios involving multiple absorbing boundary conditions, commonly found in diffusive molecular communication (MC) channels. Instead of using multiple mirror images of the source, fictitious sources with time-varying release rates are introduced to replace the boundaries. This transformation enables the calculation of the expected cumulative number of absorbed particles (CNAP) by multiple absorbing boundaries with finite volume. To compute the expected CNAP, the concept of barycenter, which represents the spatial mean of particles the receiver absorbs is introduced. Substituting absorbing objects with their barycenters leads to model the CNAP in scenarios with convex geometry of absorbers. In a one-dimensional (1D) space, the proposed approach yields the same expression as the method of images for describing the expected CNAP by an absorber. However, in three-dimensional (3D) space, where using the method of images is challenging or even impossible, the proposed approach enables substituting the objects with fictitious sources and compute the expected CNAP. In 1D, an extension of this approach to the case in which one boundary exhibits an absorption characteristic while the other has zero-flux characteristic is demonstrated. This research direction is valuable for modeling channels where not all objects are particle receptors.
本文提出了一种在涉及多个吸收边界条件的情况下处理扩散方程的方法,这种情况通常出现在扩散分子通讯(MC)通道中。该方法不使用多个源的镜像,而是引入具有时变释放率的虚构源来替代边界。通过这种转换,可以计算出具有有限体积的多个吸收边界的预期累积吸收粒子数(CNAP)。为了计算预期累积吸收粒子数,引入了 "原心 "的概念,它代表了接收器吸收粒子的空间平均值。用吸收物体的原心代替吸收物体,就能在吸收体具有凸几何形状的情况下建立 CNAP 模型。在一维(1D)空间中,所提出的方法与图像法描述吸收体预期 CNAP 的表达式相同。然而,在三维(3D)空间中,使用图像方法具有挑战性,甚至是不可能的,而所提出的方法可以用虚构源代替物体,并计算预期的 CNAP。在一维空间中,这种方法扩展到了一个边界显示吸收特性而另一个边界显示零流量特性的情况。这一研究方向对于模拟并非所有物体都是粒子受体的通道非常有价值。
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引用次数: 0
Quantitative Aspects, Engineering and Optimization of Bacterial Sensor Systems 定量方面,工程和优化细菌传感器系统
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-08-30 DOI: 10.1109/TMBMC.2024.3452066
Florian Anderl;Gabriela Salvadori;Mladen Veletic;Fernanda Cristina Petersen;Ilangko Balasingham
Bacterial sensor systems can be used for the detection and measurement of molecular signal concentrations. The dynamics of the sensor directly depend on the biological properties of the bacterial sensor cells; manipulation of these features in the wet lab enables the engineering and optimization of the bacterial sensor kinetics. This necessitates the development of biologically meaningful computational models for bacterial sensors comprising a variety of different molecular mechanisms, which further facilitates a systematic and quantitative evaluation of optimization strategies. In this work, we dissect the detection chain of bacterial sensors, focusing on computational aspects. As a case example, we derive, supported by wet-lab data, a complete computational model for a Streptococcus mutans-based bacterial sensor. We address the engineering of bacterial sensors by mathematically investigating the impact of altered bacterial cell properties on the sensor response characteristics, specifically sensor sensitivity and response signal intensity. This is achieved through a sensitivity analysis targeting both the steady-state and transient sensor response characteristics. Alongside the demonstration of the suitability of our methodological approach, our analysis shows that an increase in sensor sensitivity through targeted manipulation of bacterial physiology often comes at the cost of generally diminished sensor response intensity.
细菌传感器系统可用于分子信号浓度的检测和测量。传感器的动力学直接取决于细菌传感器细胞的生物学特性;在湿实验室中对这些特征的操作可以实现细菌传感器动力学的工程和优化。这就需要为包含各种不同分子机制的细菌传感器开发具有生物学意义的计算模型,从而进一步促进对优化策略的系统和定量评估。在这项工作中,我们剖析了细菌传感器的检测链,重点是计算方面。作为一个案例,我们推导了一个基于变形链球菌的细菌传感器的完整计算模型,并得到了湿实验室数据的支持。我们通过数学研究改变的细菌细胞特性对传感器响应特性的影响,特别是传感器灵敏度和响应信号强度,来解决细菌传感器的工程问题。这是通过针对稳态和瞬态传感器响应特性的灵敏度分析来实现的。除了证明我们的方法方法的适用性之外,我们的分析表明,通过有针对性地操纵细菌生理学来增加传感器灵敏度通常是以传感器响应强度普遍降低为代价的。
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引用次数: 0
Half-Space Modeling With Reflecting Surface in Molecular Communication 分子通信中带有反射面的半空间模型
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-08-23 DOI: 10.1109/TMBMC.2024.3448353
Anil Kamber;H. Birkan Yilmaz;Ali E. Pusane;Tuna Tugcu
In molecular communication via diffusion (MCvD), messenger molecules are emitted by a transmitter and propagate randomly through the fluidic environment. In biological systems, the environment can be considered a bounded space, surrounded by various structures such as tissues and organs. The propagation of molecules is affected by these structures, which reflect the molecules upon collision. Deriving the channel response of MCvD systems with an absorbing spherical receiver requires solving the 3-D diffusion equation in the presence of reflecting and absorbing boundary conditions, which is extremely challenging. In this paper, the method of images is brought to molecular communication (MC) realm to find a closed-form solution to the channel response of a single-input single-output (SISO) system near an infinite reflecting surface. It is shown that a molecular SISO system in a 3-D half-space with an infinite reflecting surface could be approximated as a molecular single-input multiple-output (SIMO) system in a 3-D space, which consists of two symmetrically located, with respect to the reflecting surface, identical absorbing spherical receivers.
在通过扩散进行的分子通讯(MCvD)中,信使分子由发射器发射,并在流体环境中随机传播。在生物系统中,环境可被视为一个有边界的空间,周围环绕着各种结构,如组织和器官。分子的传播会受到这些结构的影响,这些结构会在碰撞时反射分子。要推导具有吸收球形接收器的 MCvD 系统的通道响应,需要在存在反射和吸收边界条件的情况下求解三维扩散方程,这极具挑战性。本文将图像方法引入分子通信(MC)领域,为无限反射面附近的单输入单输出(SISO)系统的信道响应寻找闭式解。研究表明,在具有无限反射面的三维半空间中的分子 SISO 系统可以近似为三维空间中的分子单输入多输出(SIMO)系统,该系统由两个相对于反射面对称的相同吸收球形接收器组成。
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引用次数: 0
From Multiscale Biophysics to Digital Twins of Tissues and Organs: Future Opportunities for in-silico Pharmacology 从多尺度生物物理学到组织和器官的数字孪生:计算机药理学的未来机遇
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-08-12 DOI: 10.1109/TMBMC.2024.3442083
Michael Taynnan Barros;Michelangelo Paci;Aapo Tervonen;Elisa Passini;Jussi T. Koivumäki;Jari A. K. Hyttinen;Kerstin Lenk
With many advancements in in silico multiscale biology in recent years, the paramount challenge is to translate the accumulated knowledge into exciting industry partnerships and clinical applications. Historically, the pharmaceutical industry has worked well with in silico models by leveraging their prediction capabilities for drug testing. However, the needed higher fidelity and higher resolution of models for efficient prediction of pharmacological phenomenon dictates that in silico approaches must account for the verifiable multiscale biophysical phenomena, as a spatial and temporal dimension variation for different processes and models. Our paper has two main goals: 1) To clarify to what extent detailed single- and multiscale modeling has been accomplished thus far, we provide a review on this topic focusing on the biophysics of epithelial, cardiac, and brain tissues; 2) To discuss the present and future role of multiscale biophysics in in silico pharmacology as a digital twin solution by defining a roadmap from simple biophysical models to powerful prediction tools. Digital twins have the potential to pave the way for extensive clinical and pharmaceutical usage of multiscale models, and our paper shows the fundamentals and opportunities for their accurate development, enabling the quantum leaps of future precise and personalized medical software.
随着近年来硅多尺度生物学的许多进步,最大的挑战是将积累的知识转化为令人兴奋的行业合作伙伴关系和临床应用。从历史上看,制药行业通过利用其药物测试的预测能力,与计算机模型合作得很好。然而,为了有效地预测药理学现象,需要更高的保真度和更高的分辨率的模型,这就要求计算机方法必须考虑可验证的多尺度生物物理现象,作为不同过程和模型的空间和时间维度变化。我们的论文有两个主要目标:1)为了澄清到目前为止详细的单尺度和多尺度建模已经完成的程度,我们对这一主题进行了回顾,重点是上皮组织、心脏组织和脑组织的生物物理学;2)通过定义从简单的生物物理模型到强大的预测工具的路线图,讨论多尺度生物物理在计算机药理学中作为数字孪生解决方案的现在和未来的作用。数字孪生体有可能为多尺度模型的广泛临床和制药应用铺平道路,我们的论文展示了它们精确发展的基础和机会,使未来精确和个性化的医疗软件实现飞跃。
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引用次数: 0
Investigation of Different Chemical Realizations for Molecular Matrix Multiplications 分子矩阵乘法的不同化学实现方式研究
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-08-01 DOI: 10.1109/TMBMC.2024.3436905
Stefan Angerbauer;Nunzio Tuccitto;Giuseppe Trusso Sfrazzetto;Rossella Santonocito;Werner Haselmayr
Intelligent nano-machines are a promising candidate technology for the next generation of health care. The realization of such units relies on novel, unconventional approaches, to navigate the challenges of this particular domain. In this work, we present three chemical processes, that can be used to realize a recently proposed molecular matrix multiplication unit on the lab-scale. The matrix multiplication is the fundamental operation for the realization of neural networks and, therefore, artificial intelligence. Hence, this work presents an important step towards practical realization of intelligent nano-machines for the next generation of health care.
智能纳米机器是下一代医疗保健领域一项前景广阔的候选技术。要实现这种装置,需要采用新颖、非常规的方法,以应对这一特定领域的挑战。在这项工作中,我们介绍了三种化学过程,可用于在实验室规模上实现最近提出的分子矩阵乘法单元。矩阵乘法是实现神经网络和人工智能的基本操作。因此,这项工作是为下一代医疗保健实际实现智能纳米机器迈出的重要一步。
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引用次数: 0
Nanoantennas and Nanoradars: The Future of Integrated Sensing and Communication at the Nanoscale 纳米天线和纳米雷达:纳米尺度下集成传感和通信的未来
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-07-29 DOI: 10.1109/TMBMC.2024.3434545
M. Javad Fakhimi;Ozgur B. Akan
Nanoantennas, operating at optical frequencies, are a transformative technology with broad applications in 6G wireless communication, IoT, smart cities, healthcare, and medical imaging. This paper explores their fundamental aspects, applications, and advancements, aiming for a comprehensive understanding of their potential in various applications. It begins by investigating macroscopic and microscopic Maxwell’s equations governing electromagnetic wave propagation at different scales. The study emphasizes the critical role of surface plasmon polariton wave propagation in enhancing light-matter interactions, contributing to high data rates, and enabling miniaturization. Additionally, it explores using two-dimensional materials like graphene for enhanced control in terahertz communication and sensing. The paper also introduces the employment of nanoantennas as the main building blocks of Nano-scale Radar (NR) systems for the first time in the literature. NRs, integrated with communication signals, promise accurate radar sensing for nanoparticles inside a nano-channel, making them a potential future application in integrated sensing and communication (ISAC) systems. These nano-scale radar systems detect and extract physical or electrical properties of nanoparticles through transmitting, receiving, and processing electromagnetic waves at ultra-high frequencies in the optical range. This task requires nanoantennas as transmitters/receivers/transceivers, sharing the same frequency band and hardware for high-performance sensing and resolution.
纳米天线以光学频率工作,是一项变革性技术,在6G无线通信、物联网、智慧城市、医疗保健和医疗成像领域有着广泛的应用。本文探讨了它们的基本方面、应用和进展,旨在全面了解它们在各种应用中的潜力。它首先研究在不同尺度下控制电磁波传播的宏观和微观麦克斯韦方程组。该研究强调了表面等离子体激元波传播在增强光-物质相互作用、促进高数据速率和实现小型化方面的关键作用。此外,它还探索了使用石墨烯等二维材料来增强对太赫兹通信和传感的控制。本文还首次在文献中介绍了纳米天线作为纳米雷达系统的主要组成部分。与通信信号集成的nr有望对纳米通道内的纳米颗粒进行精确的雷达传感,使其在集成传感和通信(ISAC)系统中具有潜在的未来应用。这些纳米级雷达系统通过在光学范围内发射、接收和处理超高频率的电磁波来探测和提取纳米粒子的物理或电学特性。这项任务需要纳米天线作为发射器/接收器/收发器,共享相同的频带和硬件,以实现高性能的传感和分辨率。
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引用次数: 0
A Jamming-Resistant Molecular Communication Scheme 抗干扰分子通信方案
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-07-22 DOI: 10.1109/TMBMC.2024.3426920
Sahar Shahbaz;Mahtab Mirmohseni;Masoumeh Nasiri-Kenari
The sensitivity of many in vivo applications necessitates investigating adversarial activities in micro-scale MC systems. On the other hand, macro-scale applications of MC are easier to launch security attacks on. In this paper, we study the problem of jamming attacks in MC, where a concentration transmitter releases a particular type of molecule to send its message over a diffusive channel to a transparent receiver. A jammer wishes to disrupt the communication either by transmitting the same molecule type or a reacting molecule type. We propose jamming-resistant coding schemes to counteract this attack. For this purpose, three jamming models based on different capabilities of attackers and their possible strategies are introduced. The difference of jamming models relates to existence of sensing and learning capabilities. For two jammer types, our coding approaches are based on splitting each time slot into subslots, where a random pre-shared pattern is used to determine the transmit strategy in these subslots. The coding scheme against the third jammer type, which is the strongest one, is designed based on error correction codes with maximum Hamming distance. To analyse the performances of the proposed schemes, we derive the probability of error at the receiver. The results of the proposed schemes against the first and the second types of jammers confirm their effectiveness in protecting against jamming attacks. For example, in the specific case of the jammer channel and main channel discussed in the results section, we achieve an almost 78% reduction in the probability of errors at the receiver compared to a non-coded system when facing the first type of jammer. The third type of jammer represents the worst-case attack scenario, and its performance can be used as an upper bound for system performance.
许多体内应用的敏感性需要研究微尺度MC系统中的对抗活动。另一方面,MC的宏观应用更容易受到安全攻击。在本文中,我们研究了MC中的干扰攻击问题,其中浓度发射器释放特定类型的分子,通过扩散通道将其信息发送给透明接收器。干扰者希望通过传输相同分子类型或反应分子类型来破坏通信。我们提出了抗干扰编码方案来对抗这种攻击。为此,介绍了三种基于攻击者不同能力的干扰模型及其可能的干扰策略。干扰模型的不同与感知能力和学习能力的存在有关。对于两种类型的干扰机,我们的编码方法是基于将每个时隙划分为子时隙,其中使用随机预共享模式来确定这些子时隙中的传输策略。基于最大汉明距离的纠错码设计了针对第三种干扰机的编码方案,这是最强的一种。为了分析所提方案的性能,我们推导了接收端的误差概率。针对第一类和第二类干扰机所提出的方案的结果证实了它们在防止干扰攻击方面的有效性。例如,在结果部分讨论的干扰器信道和主信道的具体情况下,当面对第一种类型的干扰器时,与非编码系统相比,我们实现了接收器错误概率降低近78%。第三种类型的干扰机代表了最坏的攻击情况,其性能可以作为系统性能的上界。
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引用次数: 0
Designing a Light-Based Communication System With a Biomolecular Receiver 基于生物分子接收器的光通信系统设计
IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-07-15 DOI: 10.1109/TMBMC.2024.3427660
Taha Sajjad;Andrew W. Eckford
Biological systems transduce signals from their surroundings in numerous ways. This paper introduces a communication system using the light-gated ion channel Channelrhodopsin-2 (ChR2), which causes an ion current to flow in response to light. Our design includes a ChR2-based receiver along with encoding, modulation techniques and detection. Analyzing the resulting communication system, we discuss the effect of different parameters on the performance of the system. Finally, we discuss its potential design in the context of bio-engineering and light-based communication and show that the data rate scales up with the number of receptors, indicating that high-speed communication may be possible.
生物系统以多种方式从周围环境传递信号。本文介绍了一种利用光门控离子通道通道视紫红质-2 (ChR2)的通信系统,该通道能产生响应于光的离子流。我们的设计包括一个基于chr2的接收器以及编码、调制技术和检测。分析了最终的通信系统,讨论了不同参数对系统性能的影响。最后,我们讨论了其在生物工程和光通信背景下的潜在设计,并表明数据速率随着受体数量的增加而增加,这表明高速通信是可能的。
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引用次数: 0
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IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
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