首页 > 最新文献

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications最新文献

英文 中文
Guest Editorial Introduction to the Special Feature on the 7th Workshop on Molecular Communications 第七届分子通讯研讨会特稿客座编辑介绍
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3309471
Vahid Jamali;Falko Dressler;Yifan Chen;Maximilian Schäfer;Robert Schober
Molecular Communication (MC) is a highly interdisciplinary research field whose success requires the close collaboration between researchers from different fields of science. To support and highlight this interdisciplinary character, the Workshop on Molecular Communications (MolCom; https://molecularcommunications.org/) has been held annually since 2016 to provide the opportunity to meet, and share work and experience. The Workshop tries to promote research beyond the conventional disciplinary boundaries between engineering, the physical sciences, natural sciences, and medicine.
分子通讯是一个高度跨学科的研究领域,其成功需要来自不同科学领域的研究人员之间的密切合作。为了支持和强调这一跨学科性质,分子通讯讲习班(MolCom;https://molecularcommunications.org/)自2016年以来,每年都会举办一次,以提供见面、分享工作和经验的机会。该讲习班试图推动超越工程、物理科学、自然科学和医学之间传统学科界限的研究。
{"title":"Guest Editorial Introduction to the Special Feature on the 7th Workshop on Molecular Communications","authors":"Vahid Jamali;Falko Dressler;Yifan Chen;Maximilian Schäfer;Robert Schober","doi":"10.1109/TMBMC.2023.3309471","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3309471","url":null,"abstract":"Molecular Communication (MC) is a highly interdisciplinary research field whose success requires the close collaboration between researchers from different fields of science. To support and highlight this interdisciplinary character, the Workshop on Molecular Communications (MolCom; \u0000<uri>https://molecularcommunications.org/</uri>\u0000) has been held annually since 2016 to provide the opportunity to meet, and share work and experience. The Workshop tries to promote research beyond the conventional disciplinary boundaries between engineering, the physical sciences, natural sciences, and medicine.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"308-311"},"PeriodicalIF":2.2,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/6687308/10255331/10255356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67982987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IEEE Communications Society Information IEEE通信协会信息
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3292630
{"title":"IEEE Communications Society Information","authors":"","doi":"10.1109/TMBMC.2023.3292630","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3292630","url":null,"abstract":"","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"C3-C3"},"PeriodicalIF":2.2,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/6687308/10255331/10255341.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67981860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guest Editorial Special Feature on Bio-Chem-ICTs: Synergies Between Bio/Nanotechnologies and Molecular Communications 生物化学信息通信技术客座编辑特辑:生物/纳米技术与分子通信之间的协同作用
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3309488
Murat Kuscu;Pasquale Stano;Malcolm Egan;Michael T. Barros;Bige Deniz Unluturk;Gregory F. Payne
The Transfer of ‘information’ via molecules is a theme that resonates across the realm of nature, underlying collective behavior, homeostasis, and many disorders and diseases, and potentially holding the answers to some of the life’s most profound questions. The prospects of understanding and manipulating this natural modality of communication have attracted a significant research interest from information and communication theorists (ICT) over the past two decades. The aim is to provide novel means of understanding and engineering biological systems. These efforts have produced substantial body of literature that sets the groundwork for bio-inspired, artificial Molecular Communication (MC) systems. This ICT-based perspective has also contributed to the understanding of natural MC, with many of the results from these endeavors being published in this journal.
通过分子传递“信息”是一个在自然界、潜在的集体行为、体内平衡和许多疾病领域引起共鸣的主题,并可能为生活中一些最深刻的问题找到答案。在过去的二十年里,理解和操纵这种自然的通信方式的前景吸引了信息和通信理论家的极大研究兴趣。其目的是提供理解和工程化生物系统的新方法。这些努力产生了大量的文献,为生物启发的人工分子通信(MC)系统奠定了基础。这种基于信息和通信技术的观点也有助于理解自然MC,这些努力的许多结果发表在本杂志上。
{"title":"Guest Editorial Special Feature on Bio-Chem-ICTs: Synergies Between Bio/Nanotechnologies and Molecular Communications","authors":"Murat Kuscu;Pasquale Stano;Malcolm Egan;Michael T. Barros;Bige Deniz Unluturk;Gregory F. Payne","doi":"10.1109/TMBMC.2023.3309488","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3309488","url":null,"abstract":"The Transfer of ‘information’ via molecules is a theme that resonates across the realm of nature, underlying collective behavior, homeostasis, and many disorders and diseases, and potentially holding the answers to some of the life’s most profound questions. The prospects of understanding and manipulating this natural modality of communication have attracted a significant research interest from information and communication theorists (ICT) over the past two decades. The aim is to provide novel means of understanding and engineering biological systems. These efforts have produced substantial body of literature that sets the groundwork for bio-inspired, artificial Molecular Communication (MC) systems. This ICT-based perspective has also contributed to the understanding of natural MC, with many of the results from these endeavors being published in this journal.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"351-353"},"PeriodicalIF":2.2,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/6687308/10255331/10255347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67982992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Ultrasonic Power Splitting Receiver With Improved Complexity-Reliability Trade-Off for Intra-Body Communications 用于体内通信的具有改进的完整性-可靠性权衡的超声波功率分配接收器
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-14 DOI: 10.1109/TMBMC.2023.3315517
Yuankun Tang;Qianqian Wang;Miaowen Wen;Quansheng Guan;Fei Ji;Julian Cheng
Data transmission that is reliable and relies on low-complexity transceiver techniques is of practical importance for ultrasonic intra-body communications (IBCs). Considering the trade-off between reliability and computational complexity, this paper proposes an ultrasonic dynamic power splitting (UDPS) scheme. UDPS consists of statistic power splitting (SPS) and time switching (TS), where SPS splits the received signal to coherent detection (CD) and energy detection (ED) with an adjustable power splitting ratio, and TS switches between CD and ED with an adjustable power coefficient. Therefore, the proposed UDPS can exploit the reliability of CD and meanwhile benefit from the low complexity of ED. We also derive the theoretical bit-error rate (BER) of UDPS. Both theoretical and simulated results demonstrate that due to the linear noise in CD and non-linear noise in ED, the optimal power splitting ratio of SPS is 1 and the optimal power coefficient of TS is within (0, 1). More importantly, UDPS can achieve much lower complexity than CD at the cost of a slight BER loss for IBCs.
可靠且依赖低复杂度收发器技术的数据传输对超声波体内通信(IBC)具有重要的实际意义。考虑到可靠性和计算复杂性之间的权衡,本文提出了一种超声波动态功率分配(UDPS)方案。UDPS 包括统计功率分割(SPS)和时间切换(TS),其中 SPS 以可调节的功率分割比将接收到的信号分割为相干检测(CD)和能量检测(ED),TS 以可调节的功率系数在 CD 和 ED 之间切换。因此,拟议的 UDPS 可以利用 CD 的可靠性,同时受益于 ED 的低复杂性。我们还得出了 UDPS 的理论误码率 (BER)。理论和仿真结果表明,由于 CD 中的线性噪声和 ED 中的非线性噪声,SPS 的最佳功率分配比为 1,TS 的最佳功率系数在(0,1)范围内。更重要的是,UDPS 可以实现比 CD 更低的复杂度,但代价是 IBC 的误码率会略有下降。
{"title":"An Ultrasonic Power Splitting Receiver With Improved Complexity-Reliability Trade-Off for Intra-Body Communications","authors":"Yuankun Tang;Qianqian Wang;Miaowen Wen;Quansheng Guan;Fei Ji;Julian Cheng","doi":"10.1109/TMBMC.2023.3315517","DOIUrl":"10.1109/TMBMC.2023.3315517","url":null,"abstract":"Data transmission that is reliable and relies on low-complexity transceiver techniques is of practical importance for ultrasonic intra-body communications (IBCs). Considering the trade-off between reliability and computational complexity, this paper proposes an ultrasonic dynamic power splitting (UDPS) scheme. UDPS consists of statistic power splitting (SPS) and time switching (TS), where SPS splits the received signal to coherent detection (CD) and energy detection (ED) with an adjustable power splitting ratio, and TS switches between CD and ED with an adjustable power coefficient. Therefore, the proposed UDPS can exploit the reliability of CD and meanwhile benefit from the low complexity of ED. We also derive the theoretical bit-error rate (BER) of UDPS. Both theoretical and simulated results demonstrate that due to the linear noise in CD and non-linear noise in ED, the optimal power splitting ratio of SPS is 1 and the optimal power coefficient of TS is within (0, 1). More importantly, UDPS can achieve much lower complexity than CD at the cost of a slight BER loss for IBCs.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 4","pages":"483-488"},"PeriodicalIF":2.2,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Si3N4-SiO2-Based Silicon Photonics Nano-Biosensor for Molecular Communication 用于分子通信的Si3N4-SiO2基硅光子纳米生物传感器
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-31 DOI: 10.1109/TMBMC.2023.3308695
Shelma Cheeran Sajan;Anamika Singh;Prabhat Kumar Sharma;Santosh Kumar
In molecular communication (MC), information is conveyed between nano-scale transmitters and receivers using molecules. The environment sensing is a significant component of any MC system. The design of biological sensors thus is an important aspect for implementing MC systems. This paper presents a novel $textit {Si}_{{3}}{N}_{{4}}$ - $textit {SiO}_{{2}}$ silicon photonics (SiPh) nano-biosensor for detection of cancer cells. This design utilizes a micro-ring resonator (MRR) structure and takes advantage of the distinct optical characteristics of various cancer cells and MC by leveraging the interaction between cancer cells and CD47 proteins. The proposed sensor design can be used in artificial nano-machines deployed in a MC system for the applications like cancer cell detection and targeted drug delivery.
在分子通信(MC)中,使用分子在纳米级发射器和接收器之间传递信息。环境传感是任何MC系统的重要组成部分。因此,生物传感器的设计是实现MC系统的一个重要方面。这篇论文提出了一篇小说$textit{Si}_{{3}}{N}_{{4}}$-$textit{SiO}_{{2}}$用于检测癌症细胞的硅光子(SiPh)纳米生物传感器。该设计利用了微共振腔(MRR)结构,并通过利用癌症细胞和CD47蛋白之间的相互作用,利用了各种癌症细胞和MC的独特光学特性。所提出的传感器设计可用于MC系统中部署的人工纳米机器,用于癌症细胞检测和靶向药物递送等应用。
{"title":"Si3N4-SiO2-Based Silicon Photonics Nano-Biosensor for Molecular Communication","authors":"Shelma Cheeran Sajan;Anamika Singh;Prabhat Kumar Sharma;Santosh Kumar","doi":"10.1109/TMBMC.2023.3308695","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3308695","url":null,"abstract":"In molecular communication (MC), information is conveyed between nano-scale transmitters and receivers using molecules. The environment sensing is a significant component of any MC system. The design of biological sensors thus is an important aspect for implementing MC systems. This paper presents a novel \u0000<inline-formula> <tex-math>$textit {Si}_{{3}}{N}_{{4}}$ </tex-math></inline-formula>\u0000-\u0000<inline-formula> <tex-math>$textit {SiO}_{{2}}$ </tex-math></inline-formula>\u0000 silicon photonics (SiPh) nano-biosensor for detection of cancer cells. This design utilizes a micro-ring resonator (MRR) structure and takes advantage of the distinct optical characteristics of various cancer cells and MC by leveraging the interaction between cancer cells and CD47 proteins. The proposed sensor design can be used in artificial nano-machines deployed in a MC system for the applications like cancer cell detection and targeted drug delivery.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"340-345"},"PeriodicalIF":2.2,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67982993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network Medicine: From Conceptual Frameworks to Applications and Future Trends 网络医学:从概念框架到应用和未来趋势
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-25 DOI: 10.1109/TMBMC.2023.3308689
Enes Sefa Ayar;Sina Dadmand;Nurcan Tuncbag
The intricate nature of biological processes is orchestrated by molecular interactions. The complexity of these interactions stems from the sheer number of components involved and their relationships. To overcome this complexity, network medicine adopts a holistic, integrative approach at multiple levels. The human interactome involves over 100,000 molecules, including proteins, RNAs, and metabolites, all interconnected by a network of connections. One challenge in understanding the human interactome is associating specific parts of this network with biological phenomena such as diseases, drug resistance, and other abnormalities. Although molecular measurements can quantitatively identify many altered molecules, making sense of these molecular changes within the broader network context is a formidable task. Notably, alterations in the human interactome often occur in closely connected regions of the network. By using prior biological knowledge and applying the context-specific molecular interplays, specific sub-networks can be extracted. These network modules can provide valuable insights into complex biological questions. Furthermore, a range of learning and graph-based methodologies are employed to deduce meaningful clinical outcomes in these modules. In this context, we present a comprehensive overview of the standard workflows utilized in network medicine, along with a discussion of its applications and future directions.
生物过程的复杂性是由分子相互作用协调的。这些相互作用的复杂性源于所涉及的组件数量及其关系。为了克服这种复杂性,网络医学在多个层面上采用了整体、综合的方法。人类相互作用组涉及超过100000个分子,包括蛋白质、RNA和代谢物,所有这些都通过连接网络相互连接。理解人类相互作用机制的一个挑战是将这个网络的特定部分与疾病、耐药性和其他异常等生物现象联系起来。尽管分子测量可以定量识别许多改变的分子,但在更广泛的网络环境中理解这些分子变化是一项艰巨的任务。值得注意的是,人类互动机制的改变经常发生在网络的紧密连接区域。通过使用先前的生物学知识并应用上下文特定的分子相互作用,可以提取特定的子网络。这些网络模块可以为复杂的生物学问题提供有价值的见解。此外,在这些模块中,还采用了一系列基于学习和图形的方法来推断有意义的临床结果。在此背景下,我们全面概述了网络医学中使用的标准工作流程,并讨论了其应用和未来方向。
{"title":"Network Medicine: From Conceptual Frameworks to Applications and Future Trends","authors":"Enes Sefa Ayar;Sina Dadmand;Nurcan Tuncbag","doi":"10.1109/TMBMC.2023.3308689","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3308689","url":null,"abstract":"The intricate nature of biological processes is orchestrated by molecular interactions. The complexity of these interactions stems from the sheer number of components involved and their relationships. To overcome this complexity, network medicine adopts a holistic, integrative approach at multiple levels. The human interactome involves over 100,000 molecules, including proteins, RNAs, and metabolites, all interconnected by a network of connections. One challenge in understanding the human interactome is associating specific parts of this network with biological phenomena such as diseases, drug resistance, and other abnormalities. Although molecular measurements can quantitatively identify many altered molecules, making sense of these molecular changes within the broader network context is a formidable task. Notably, alterations in the human interactome often occur in closely connected regions of the network. By using prior biological knowledge and applying the context-specific molecular interplays, specific sub-networks can be extracted. These network modules can provide valuable insights into complex biological questions. Furthermore, a range of learning and graph-based methodologies are employed to deduce meaningful clinical outcomes in these modules. In this context, we present a comprehensive overview of the standard workflows utilized in network medicine, along with a discussion of its applications and future directions.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"374-381"},"PeriodicalIF":2.2,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67981861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Complexity Timing Methods for Molecular Communication via Diffusion 通过扩散实现分子通信的低复杂度计时方法
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-15 DOI: 10.1109/TMBMC.2023.3305390
Umut Eren Usturalı;Bayram Cevdet Akdeniz;Tuna Tuğcu;Ali Emre Pusane
Molecular communication is expected to be instrumental in the advancement of nanotechnology. Implementation of robust molecular communication channels that work in conjunction with other nanodevices necessitates the development of synchronization techniques for such systems. Although a number of works exist in this area, most of the proposed solutions are infeasible given the computational limitations of the components. In this paper, we propose two related methods within the framework of molecular communication via diffusion (MCvD) paradigm. These methods require only the most basic computational resources. We assess their performance analytically and computationally, indicate the error margins for each one, and discuss when one is more useful than the other.
分子通讯有望推动纳米技术的发展。要实现与其他纳米器件协同工作的稳健分子通信信道,就必须为此类系统开发同步技术。虽然在这一领域有许多工作,但由于组件的计算限制,大多数建议的解决方案都不可行。在本文中,我们在通过扩散进行分子通讯(MCvD)范式的框架内提出了两种相关方法。这些方法只需要最基本的计算资源。我们对它们的性能进行了分析和计算评估,指出了每种方法的误差范围,并讨论了何时一种方法比另一种方法更有用。
{"title":"Low-Complexity Timing Methods for Molecular Communication via Diffusion","authors":"Umut Eren Usturalı;Bayram Cevdet Akdeniz;Tuna Tuğcu;Ali Emre Pusane","doi":"10.1109/TMBMC.2023.3305390","DOIUrl":"10.1109/TMBMC.2023.3305390","url":null,"abstract":"Molecular communication is expected to be instrumental in the advancement of nanotechnology. Implementation of robust molecular communication channels that work in conjunction with other nanodevices necessitates the development of synchronization techniques for such systems. Although a number of works exist in this area, most of the proposed solutions are infeasible given the computational limitations of the components. In this paper, we propose two related methods within the framework of molecular communication via diffusion (MCvD) paradigm. These methods require only the most basic computational resources. We assess their performance analytically and computationally, indicate the error margins for each one, and discuss when one is more useful than the other.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 4","pages":"478-482"},"PeriodicalIF":2.2,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79312616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable Electrochemical Sensors for Healthcare Monitoring: A Review of Current Developments and Future Prospects 医疗监护用可穿戴电化学传感器的发展现状与展望
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-10 DOI: 10.1109/TMBMC.2023.3304240
Fariborz Mirlou;Levent Beker
Wearable devices and biosensors have gained significant attention due to their high potential to continuously monitor the biomarkers in human body biofluids through non-invasive and minimally invasive methods and give feedback to the users in real-time. Numerous developments have been made in the electrochemical devices field for the non-invasive measurements of the desired biomarkers, including detecting different electrolytes, metabolites, and hormones. Integrating multiplexed human health monitoring, using biosensors, and transmitting the acquired data using wireless systems has been achieved and miniaturized. These systems have been combined with flexible materials to enhance their conformability and easy use. Such precise monitoring of the target biomarker and physiological data through wearable devices would significantly improve life quality by providing critical health-related information in real time. On the other hand, there needs to be an in-depth understanding of analyte concentrations in blood and their correlation to other biofluids, which will help improve the biosensors’ reliability. Thus, conducting large-scale in-vivo studies on different subjects using wearable biosensors and clinical equipment is an essential validation factor for the biosensors. Here, we focus on wearable electrochemical devices that can non-invasively measure and track the human body’s vital health information and transmit it to the users’ mobile devices.
可穿戴设备和生物传感器由于其通过无创和微创方法持续监测人体生物流体中的生物标志物并实时向用户提供反馈的高潜力而备受关注。电化学设备领域已经取得了许多进展,用于所需生物标志物的非侵入性测量,包括检测不同的电解质、代谢物和激素。已经实现并小型化了多路复用人类健康监测、使用生物传感器和使用无线系统传输采集的数据。这些系统已与柔性材料相结合,以增强其适应性和易用性。通过可穿戴设备对目标生物标志物和生理数据的这种精确监测将通过实时提供关键的健康相关信息来显著提高生活质量。另一方面,需要深入了解血液中的分析物浓度及其与其他生物流体的相关性,这将有助于提高生物传感器的可靠性。因此,使用可穿戴生物传感器和临床设备对不同受试者进行大规模体内研究是生物传感器的一个重要验证因素。在这里,我们专注于可穿戴电化学设备,它可以无创地测量和跟踪人体的重要健康信息,并将其传输到用户的移动设备。
{"title":"Wearable Electrochemical Sensors for Healthcare Monitoring: A Review of Current Developments and Future Prospects","authors":"Fariborz Mirlou;Levent Beker","doi":"10.1109/TMBMC.2023.3304240","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3304240","url":null,"abstract":"Wearable devices and biosensors have gained significant attention due to their high potential to continuously monitor the biomarkers in human body biofluids through non-invasive and minimally invasive methods and give feedback to the users in real-time. Numerous developments have been made in the electrochemical devices field for the non-invasive measurements of the desired biomarkers, including detecting different electrolytes, metabolites, and hormones. Integrating multiplexed human health monitoring, using biosensors, and transmitting the acquired data using wireless systems has been achieved and miniaturized. These systems have been combined with flexible materials to enhance their conformability and easy use. Such precise monitoring of the target biomarker and physiological data through wearable devices would significantly improve life quality by providing critical health-related information in real time. On the other hand, there needs to be an in-depth understanding of analyte concentrations in blood and their correlation to other biofluids, which will help improve the biosensors’ reliability. Thus, conducting large-scale in-vivo studies on different subjects using wearable biosensors and clinical equipment is an essential validation factor for the biosensors. Here, we focus on wearable electrochemical devices that can non-invasively measure and track the human body’s vital health information and transmit it to the users’ mobile devices.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"364-373"},"PeriodicalIF":2.2,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67981862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Molecular Robotics to Molecular Cybernetics: The First Step Toward Chemical Artificial Intelligence 从分子机器人到分子控制论:迈向化学人工智能的第一步
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-10 DOI: 10.1109/TMBMC.2023.3304243
Akinori Kuzuya;Shin-Ichiro M. Nomura;Taro Toyota;Takashi Nakakuki;Satoshi Murata
“Molecular Cybernetics” is an emerging research field aiming the development of “Chemical AI”, artificial intelligence with memory and learning capabilities based on molecular communication. It is originated from “Molecular Robotics,” which studies molecular systems that comprise of the three basic elements of robots; Sensing, Planning, and Acting. Development of an Amoeba-type molecular robot (unicellular artificial cell,) motivated the construction of multicellular artificial cell systems mimicking nerve systems. The major challenges in molecular cybernetics are molecular communication over two lipid-bilayer compartments, amplification of molecular information in a compartment, and large deformation of the compartment triggered by molecular signal, etc. Recently reported molecular devices and systems that contributes to the realization of Chemical AI are overviewed.
“分子控制论”是一个新兴的研究领域,旨在发展“化学人工智能”,即基于分子通信的具有记忆和学习能力的人工智能。它起源于“分子机器人学”,研究由机器人的三个基本元素组成的分子系统;感知、规划和行动。阿米巴型分子机器人(单细胞人工细胞)的开发推动了模仿神经系统的多细胞人工细胞系统的构建。分子控制论的主要挑战是两个脂质双层隔室的分子通信、隔室中分子信息的放大以及分子信号触发的隔室的大变形等。综述了最近报道的有助于实现化学人工智能的分子设备和系统。
{"title":"From Molecular Robotics to Molecular Cybernetics: The First Step Toward Chemical Artificial Intelligence","authors":"Akinori Kuzuya;Shin-Ichiro M. Nomura;Taro Toyota;Takashi Nakakuki;Satoshi Murata","doi":"10.1109/TMBMC.2023.3304243","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3304243","url":null,"abstract":"“Molecular Cybernetics” is an emerging research field aiming the development of “Chemical AI”, artificial intelligence with memory and learning capabilities based on molecular communication. It is originated from “Molecular Robotics,” which studies molecular systems that comprise of the three basic elements of robots; Sensing, Planning, and Acting. Development of an Amoeba-type molecular robot (unicellular artificial cell,) motivated the construction of multicellular artificial cell systems mimicking nerve systems. The major challenges in molecular cybernetics are molecular communication over two lipid-bilayer compartments, amplification of molecular information in a compartment, and large deformation of the compartment triggered by molecular signal, etc. Recently reported molecular devices and systems that contributes to the realization of Chemical AI are overviewed.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"354-363"},"PeriodicalIF":2.2,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/6687308/10255331/10214301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67982995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distance Estimation From a Diffusive Process: Theoretical Limits and Experimental Results 扩散过程的距离估计:理论极限和实验结果
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-08-08 DOI: 10.1109/TMBMC.2023.3303363
Fabio Broghammer;Siwei Zhang;Thomas Wiedemann;Peter A. Hoeher
Estimating the distance between the source of a diffusive process and a receiver has a variety of applications, ranging from gas source localization at the macro-scale to molecular communication at the micro-scale. Distance information can be extracted from features of the observed particle concentration, e.g., its peak. This paper derives the Cramér-Rao lower bound (CRB) for distance estimation given the advection-diffusion model for absorbing receivers, which is the fundamental limit of any distance estimator. Furthermore, CRBs are obtained for estimators using only information about the observed peak. A maximum-likelihood estimator using the entire signal and two estimators based on peak detection are deduced. The derived CRBs are used to study the effect of channel parameters on the estimation performance. Finally, the performance of the proposed estimators is verified by comparing the root mean squared errors with their theoretical bounds in a simulation, and preliminary experimental results are presented.
估算扩散过程的源和接收器之间的距离有多种应用,从宏观尺度的气源定位到微观尺度的分子通信。距离信息可以从观察到的颗粒浓度的特征中提取,例如其峰值。本文在吸收式接收器的平流-扩散模型下,导出了距离估计的Cramér-Rao下界(CRB),这是任何距离估计的基本极限。此外,仅使用关于观测到的峰值的信息来获得用于估计器的CRB。推导了一个使用整个信号的最大似然估计器和两个基于峰值检测的估计器。导出的CRB用于研究信道参数对估计性能的影响。最后,通过将均方根误差与理论界进行仿真比较,验证了所提出的估计量的性能,并给出了初步的实验结果。
{"title":"Distance Estimation From a Diffusive Process: Theoretical Limits and Experimental Results","authors":"Fabio Broghammer;Siwei Zhang;Thomas Wiedemann;Peter A. Hoeher","doi":"10.1109/TMBMC.2023.3303363","DOIUrl":"https://doi.org/10.1109/TMBMC.2023.3303363","url":null,"abstract":"Estimating the distance between the source of a diffusive process and a receiver has a variety of applications, ranging from gas source localization at the macro-scale to molecular communication at the micro-scale. Distance information can be extracted from features of the observed particle concentration, e.g., its peak. This paper derives the Cramér-Rao lower bound (CRB) for distance estimation given the advection-diffusion model for absorbing receivers, which is the fundamental limit of any distance estimator. Furthermore, CRBs are obtained for estimators using only information about the observed peak. A maximum-likelihood estimator using the entire signal and two estimators based on peak detection are deduced. The derived CRBs are used to study the effect of channel parameters on the estimation performance. Finally, the performance of the proposed estimators is verified by comparing the root mean squared errors with their theoretical bounds in a simulation, and preliminary experimental results are presented.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"9 3","pages":"312-317"},"PeriodicalIF":2.2,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/6687308/10255331/10210712.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67982986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1