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About the cover. 关于封面。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-10-30 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2137207
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引用次数: 0
About the cover. 关于封面。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-09-30 DOI: 10.1080/23328940.2022.2129144
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引用次数: 0
Working in a warming world: Translating thermal physiology to policy-relevant information. 在变暖的世界中工作:将热生理学转化为政策相关信息。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-09-30 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2086414
Andreas D Flouris, Leonidas G Ioannou, Lars Nybo
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引用次数: 0
Indicators to assess physiological heat strain - Part 1: Systematic review. 生理热负荷评估指标 - 第 1 部分:系统回顾。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-07-31 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2037376
Leonidas G Ioannou, Konstantinos Mantzios, Lydia Tsoutsoubi, Sean R Notley, Petros C Dinas, Matt Brearley, Yoram Epstein, George Havenith, Michael N Sawka, Peter Bröde, Igor B Mekjavic, Glen P Kenny, Thomas E Bernard, Lars Nybo, Andreas D Flouris

In a series of three companion papers published in this Journal, we identify and validate the available thermal stress indicators (TSIs). In this first paper of the series, we conducted a systematic review (registration: INPLASY202090088) to identify all TSIs and provide reliable information regarding their use (funded by EU Horizon 2020; HEAT-SHIELD). Eight databases (PubMed, Agricultural and Environmental Science Collection, Web of Science, Scopus, Embase, Russian Science Citation Index, MEDLINE, and Google Scholar) were searched from database inception to 15 April 2020. No restrictions on language or study design were applied. Of the 879 publications identified, 232 records were considered for further analysis. This search identified 340 instruments and indicators developed between 200 BC and 2019 AD. Of these, 153 are nomograms, instruments, and/or require detailed non-meteorological information, while 187 can be mathematically calculated utilizing only meteorological data. Of these meteorology-based TSIs, 127 were developed for people who are physically active, and 61 of those are eligible for use in occupational settings. Information regarding the equation, operating range, interpretation categories, required input data, as well as a free software to calculate all 187 meteorology-based TSIs is provided. The information presented in this systematic review should be adopted by those interested in performing on-site monitoring and/or big data analytics for climate services to ensure appropriate use of the meteorology-based TSIs. Studies two and three in this series of companion papers present guidance on the application and validation of these TSIs, to guide end users of these indicators for more effective use.

在本期刊发表的三篇系列论文中,我们确定并验证了现有的热应力指标(TSIs)。在该系列的第一篇论文中,我们进行了一项系统性综述(注册号:INPLASY202090088),以确定所有 TSIs 并提供有关其使用的可靠信息(由欧盟地平线 2020;HEAT-SHIELD 资助)。从数据库建立到 2020 年 4 月 15 日,共检索了八个数据库(PubMed、农业与环境科学文库、科学网、Scopus、Embase、俄罗斯科学引文索引、MEDLINE 和谷歌学术)。对语言或研究设计没有任何限制。在确定的 879 篇出版物中,有 232 条记录被考虑用于进一步分析。此次检索发现了公元前 200 年至公元 2019 年期间开发的 340 种工具和指标。其中,153 种是名义图、工具和/或需要详细的非气象信息,而 187 种则可以仅利用气象数据进行数学计算。在这些基于气象学的 TSI 中,有 127 种是为身体活跃的人群开发的,其中 61 种可用于职业环境。本文提供了有关方程、工作范围、解释类别、所需输入数据的信息,以及计算所有 187 个基于气象的 TSI 的免费软件。有兴趣为气候服务进行现场监测和/或大数据分析的人士应采纳本系统综述中提供的信息,以确保适当使用基于气象的 TSIs。本系列配套文件中的研究二和研究三介绍了这些TSI的应用和验证指南,以指导这些指标的最终用户更有效地使用这些指标。
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引用次数: 0
Heat acclimation does not negatively affect salivary immunoglobulin-A and self-reported illness symptoms and wellness in recreational athletes. 热驯化对休闲运动员的唾液免疫球蛋白a和自述疾病症状和健康没有负面影响。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2088029
Puck Alkemade, Nicola Gerrett, Hein A M Daanen, Thijs M H Eijsvogels, Thomas W J Janssen, Lauren C Keaney

Heat acclimation (HA) protocols repeatedly expose individuals to heat stress. As HA is typically performed close to the pinnacle event, it is essential that the protocol does not compromise immune status, health, or wellbeing. The purpose of this study was to examine the effect of HA on resting salivary immunoglobulin-A (s-IgA) and salivary cortisol (s-cortisol), self-reported upper-respiratory tract symptoms, and self-reported wellness parameters. Seventeen participants (peak oxygen uptake 53.2 ± 9.0 mL·kg-1·min-1) completed a 10-day controlled-hyperthermia HA protocol, and a heat stress test both before (HST1) and after (HST2) HA (33°C, 65% relative humidity). Resting saliva samples were collected at HST1, day 3 and 7 of the HA protocol, HST2, and at 5 ± 1 days post-HA. Upper-respiratory tract symptom data were collected weekly from one week prior to HA until three weeks post HA, and wellness ratings were reported daily throughout HA. HA successfully induced physiological adaptations, with a lower end-exercise rectal temperature and heart rate and higher whole-body sweat rate at HST2 compared to HST1. In contrast, resting saliva flow rate, s-IgA concentration, s-cortisol concentration, and s-cortisol secretion rate remained unchanged (n = 11-14, P = 0.10-0.48). Resting s-IgA secretion rate increased by 39% from HST1 to HST2 (n = 14, P = 0.03). No changes were observed in self-reported upper respiratory tract symptoms and wellness ratings. In conclusion, controlled-hyperthermia HA did not negatively affect resting s-IgA and s-cortisol, self-reported upper-respiratory tract symptoms, and self-reported wellness parameters in recreational athletes.

热驯化(HA)协议反复暴露个体热应激。由于HA通常在接近顶峰事件时进行,因此协议必须不损害免疫状态,健康或福祉。本研究的目的是检验透明质酸对静息唾液免疫球蛋白a (s-IgA)和唾液皮质醇(s-皮质醇)、自我报告的上呼吸道症状和自我报告的健康参数的影响。17名参与者(峰值摄氧量53.2±9.0 mL·kg-1·min-1)完成了为期10天的控制热疗HA方案,并在(HST1)之前和(HST2)之后(33°C, 65%相对湿度)进行了热应激测试。静息唾液样本于HA方案的HST1、第3天和第7天、HST2和HA后5±1天采集。从HA前一周到HA后三周,每周收集上呼吸道症状数据,并在HA期间每天报告健康评分。透明质酸成功诱导了生理适应,与HST1相比,HST2的运动末期直肠温度和心率较低,全身出汗率较高。静息唾液流速、s-IgA浓度、s-皮质醇浓度、s-皮质醇分泌率保持不变(n = 11-14, P = 0.10-0.48)。静息s-IgA分泌率从HST1到HST2增加39% (n = 14, P = 0.03)。自我报告的上呼吸道症状和健康评分没有变化。总之,控制热疗HA对休闲运动员静息s-IgA和s-皮质醇、自我报告的上呼吸道症状和自我报告的健康参数没有负面影响。
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引用次数: 0
Small changes in thermal conditions hinder marathon running performance in the tropics. 热量条件的微小变化会影响热带地区的马拉松比赛成绩。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-07-15 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2086777
Glenn C W Tan, Kaiyuan Zheng, Wee K Cheong, Christopher Byrne, Jan N Iversen, Jason K W Lee

We examined marathon performance of the same group of runners in relation to small changes in dry bulb temperature (Tdb) and wet bulb temperature (Twb) across 3 consecutive y, and investigated whether performance was poorer during an evening marathon compared with morning marathons. Marathon results were obtained from the 2017, 2018, and 2019 Standard Chartered Singapore Marathons. Tdb, Twb, Td, relative humidity, and absolute humidity were gathered for each marathon. K-means clustering and linear regressions were performed on 610 runners who participated in all three marathons. Analysis of the 610 runners' marathon performance was contrasted with Tdb and Twb. Linear regressions were also performed on 190 runners filtered by percentile, yielding similar results. For clusters with similar Tdb from all runners K-means clustering, an increase in mean Twb by 1.5°C coincided with an increase in finishing time by 559 s (9.3 min) (p < 0.033). Twb hinders marathon performance more than Tdb, with each percentage rise in Tdb and Twb resulting in an increase in net time by 7.6% and 39.1%, respectively (p < 0.025). Male and female runners' response to Tdb and Twb changes were similar (overlap in 95% confidence intervals for the respective regression coefficients). In conclusion, small variations in environmental parameters affected marathon performance, with Twb impairing marathon performance more than Tdb. Marathon performance was likely better in the morning than evening, possibly due to time of day differences, along with unfavorable Tdb that superseded training effects and the effects of lower Twb.

我们研究了同一组选手在连续 3 年中干球温度(Tdb)和湿球温度(Twb)的微小变化与马拉松成绩的关系,并调查了晚间马拉松与早晨马拉松相比成绩是否更差。马拉松成绩来自 2017 年、2018 年和 2019 年渣打银行新加坡马拉松赛。收集了每场马拉松比赛的 Tdb、Twb、Td、相对湿度和绝对湿度。对参加所有三个马拉松赛事的 610 名选手进行了 K 均值聚类和线性回归。将这 610 名选手的马拉松成绩与 Tdb 和 Twb 进行对比分析。此外,还对按百分位数筛选出的 190 名选手进行了线性回归,得出了类似的结果。对于来自所有跑步者的具有相似 Tdb 的 K-means 聚类,平均 Twb 升高 1.5 摄氏度时,完赛时间增加 559 秒(9.3 分钟)(p wb 比 Tdb 对马拉松成绩的阻碍更大,Tdb 和 Twb 每升高一个百分点,净时间分别增加 7.6% 和 39.1%(p db 和 Twb 变化相似(各自回归系数的 95% 置信区间重叠))。总之,环境参数的微小变化会影响马拉松成绩,Twb 比 Tdb 对马拉松成绩的影响更大。早晨的马拉松成绩可能比傍晚好,这可能是由于一天中的时间差异,以及不利的 Tdb 取代了训练效果和较低的 Twb 的影响。
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引用次数: 0
Indicators to assess physiological heat strain - Part 3: Multi-country field evaluation and consensus recommendations. 生理热应变评定指标。第3部分:多国现场评价和一致建议
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-04-01 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2022.2044739
Leonidas G Ioannou, Lydia Tsoutsoubi, Konstantinos Mantzios, Maria Vliora, Eleni Nintou, Jacob F Piil, Sean R Notley, Petros C Dinas, George A Gourzoulidis, George Havenith, Matt Brearley, Igor B Mekjavic, Glen P Kenny, Lars Nybo, Andreas D Flouris

In a series of three companion papers published in this Journal, we identify and validate the available thermal stress indicators (TSIs). In this third paper, we conducted field experiments across nine countries to evaluate the efficacy of 61 meteorology-based TSIs for assessing the physiological strain experienced by individuals working in the heat. We monitored 372 experi-enced and acclimatized workers during 893 full work shifts. We continuously assessed core body temperature, mean skin temperature, and heart rate data together with pre/post urine specific gravity and color. The TSIs were evaluated against 17 published criteria covering physiological parameters, practicality, cost effectiveness, and health guidance issues. Simple meteorological parameters explained only a fraction of the variance in physiological heat strain (R2 = 0.016 to 0.427; p < 0.001), reflecting the importance of adopting more sophisticated TSIs. Nearly all TSIs correlated with mean skin temperature (98%), mean body temperature (97%), and heart rate (92%), while 66% of TSIs correlated with the magnitude of dehydration and 59% correlated with core body temperature (r = 0.031 to 0.602; p < 0.05). When evaluated against the 17 published criteria, the TSIs scored from 4.7 to 55.4% (max score = 100%). The indoor (55.4%) and outdoor (55.1%) Wet-Bulb Globe Temperature and the Universal Thermal Climate Index (51.7%) scored higher compared to other TSIs (4.7 to 42.0%). Therefore, these three TSIs have the highest potential to assess the physiological strain experienced by individuals working in the heat.

在本杂志发表的一系列三篇配套论文中,我们确定并验证了可用的热应力指标(tsi)。在这第三篇论文中,我们在9个国家进行了实地实验,以评估61种基于气象的tsi在评估高温下工作的个体所经历的生理应变方面的功效。我们对372名经验丰富、适应环境的工人进行了893次轮班监测。我们持续评估核心体温、平均皮肤温度和心率数据,以及前后尿液比重和颜色。根据17项已公布的标准对tsi进行了评估,这些标准涵盖了生理参数、实用性、成本效益和健康指导问题。简单的气象参数只能解释生理热应变变化的一小部分(R2 = 0.016 ~ 0.427;p
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引用次数: 22
Increased air temperature decreases high-speed, but not total distance, in international field hockey. 在国际曲棍球比赛中,气温升高会降低速度,但不会降低总距离。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-12-16 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2021.1997535
Carl A James, Ashley G B Willmott, Aishwar Dhawan, Craig Stewart, Oliver R Gibson

This study investigated the effect of heat stress on locomotor activity within international field hockey at team, positional and playing-quarter levels. Analysis was conducted on 71 matches played by the Malaysia national men's team against 24 opponents. Fixtures were assigned to match conditions, based on air temperature [COOL (14 ± 3°C), WARM (24 ± 1°C), HOT (27 ± 1°C), or VHOT (32 ± 2°C), p < 0.001]. Relationships between locomotor metrics and air temperature (AIR), absolute and relative humidity, and wet bulb globe temperature (WBGT) were investigated further using correlation and regression analyses. Increased AIR and WBGT revealed similar correlations (p < 0.01) with intensity metrics; high-speed running (AIR r = -0.51, WBGT r = -0.45), average speed (AIR r = -0.48, WBGT r = -0.46), decelerations (AIR r = -0.41, WBGT r = -0.41), sprinting efforts (AIR r = -0.40, WBGT r = -0.36), and sprinting distance (AIR r = -0.37, WBGT r = -0.29). In comparison to COOL, HOT, and VHOT matches demonstrated reduced high-speed running intensity (-14-17%; p < 0.001), average speed (-5-6%; p < 0.001), sprinting efforts (-17%; p = 0.010) and decelerations per min (-12%; p = 0.008). Interactions were found between match conditions and playing quarter for average speed (+4-7%; p = 0.002) and sprinting distance (+16-36%; p < 0.001), both of which were higher in the fourth quarter in COOL versus WARM, HOT and VHOT. There was an interaction for "low-speed" (p < 0.001), but not for "high-speed" running (p = 0.076) demonstrating the modulating effect of air temperature (particularly >25°C) on pacing within international hockey. These are the first data demonstrating the effect of air temperature on locomotor activity within international men's hockey, notably that increased air temperature impairs high-intensity activities by 5-15%. Higher air temperatures compromise high-speed running distances between matches in hockey.

本研究探讨了热应激对国际曲棍球运动员在团队、位置和比赛阶段运动活动的影响。分析了马来西亚国家男队与24个对手进行的71场比赛。根据空气温度[COOL(14±3°C), WARM(24±1°C), HOT(27±1°C),或VHOT(32±2°C), pr = -0.51, WBGT r = -0.45),平均速度(air r = -0.48, WBGT r = -0.46),减速(air r = -0.41, WBGT r = -0.41),冲刺努力(air r = -0.40, WBGT r = -0.36)和冲刺距离(air r = -0.37, WBGT r = -0.29)分配夹具。与COOL, HOT和VHOT匹配相比,高速跑步强度降低(-14-17%;P P P = 0.010)和每分钟减速度(-12%;P = 0.008)。比赛条件和比赛时间对平均速度的影响(+4-7%;P = 0.002)和短跑距离(+16-36%;p与WARM, HOT和VHOT。在国际冰球比赛中,“低速”(p p = 0.076)存在相互作用,表明气温(特别是>25°C)对速度的调节作用。这是第一次有数据表明气温对国际男子曲棍球运动活动的影响,特别是气温升高会使高强度活动减少5-15%。较高的气温会影响曲棍球比赛之间的高速奔跑距离。
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引用次数: 3
Influences of ovarian hormones on physiological responses to cold in women 卵巢激素对女性寒冷生理反应的影响
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-09-14 DOI: 10.1080/23328940.2021.1953688
Andrew M. Greenfield, N. Charkoudian, Billie K. Alba
ABSTRACT While it is clear that the ovarian hormones estradiol and progesterone have important influences on physiological thermoregulation in women, the influences of these hormones on responses to cold exposure are not well understood. Both heat conservation and heat production must increase to offset heat losses that decrease body temperature in cold ambient conditions. Cutaneous vasoconstriction conserves heat, whereas shivering and non-shivering thermogenesis produce heat – all as part of reflex physiological responses to cold exposure. Our goal in this brief review is to highlight existing knowledge and recent advances pertaining to sex and sex hormone influences on thermoeffector responses to cold stress. Estrogens have multiple influences that contribute to heat dissipation and a lower body temperature, while the influence of progesterone appears to primarily increase body temperature. Fluctuations in estrogen and progesterone across the menstrual cycle can alter the level at which body temperature is regulated. Recent evidence suggests that female reproductive hormones can modulate the cutaneous vasoconstrictor response, and may influence metabolic mechanisms such as substrate utilization during shivering and non-shivering thermogenesis. Overall, it appears that quantitative differences in cold thermoregulation between sexes are minimal when anthropometric measures are minimized, such that women do not have a strong “advantage” or “disadvantage” in terms of overall ability to tolerate cold. Thermoregulatory physiology in women during cold exposure remains relatively understudied and many mechanisms require further elucidation.
摘要尽管卵巢激素雌二醇和孕酮对女性生理体温调节有重要影响,但这些激素对冷暴露反应的影响尚不清楚。热量节约和热量产生都必须增加,以抵消在寒冷环境条件下降低体温的热量损失。皮肤血管收缩保存热量,而颤抖和非颤抖产热产生热量——所有这些都是对寒冷暴露的反射生理反应的一部分。我们在这篇简短综述中的目标是强调与性和性激素对冷应激热效应反应的影响有关的现有知识和最新进展。雌激素有多种影响,有助于散热和降低体温,而孕酮的影响似乎主要是增加体温。整个月经周期雌激素和孕激素的波动会改变体温的调节水平。最近的证据表明,女性生殖激素可以调节皮肤血管收缩反应,并可能影响代谢机制,如在颤抖和非颤抖产热过程中底物的利用。总的来说,当人体测量措施最小化时,两性之间在体温调节方面的数量差异似乎是最小的,因此女性在忍受寒冷的总体能力方面没有很强的“优势”或“劣势”。女性在寒冷暴露期间的体温调节生理学研究相对不足,许多机制需要进一步阐明。
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引用次数: 8
Human cold habituation: Physiology, timeline, and modifiers. 人类冷习惯:生理学、时间线和修饰。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-05-25 eCollection Date: 2022-01-01 DOI: 10.1080/23328940.2021.1903145
Beau R Yurkevicius, Billie K Alba, Afton D Seeley, John W Castellani

Habituation is an adaptation seen in many organisms, defined by a reduction in the response to repeated stimuli. Evolutionarily, habituation is thought to benefit the organism by allowing conservation of metabolic resources otherwise spent on sub-lethal provocations including repeated cold exposure. Hypermetabolic and/or insulative adaptations may occur after prolonged and severe cold exposures, resulting in enhanced cold defense mechanisms such as increased thermogenesis and peripheral vasoconstriction, respectively. Habituation occurs prior to these adaptations in response to short duration mild cold exposures, and, perhaps counterintuitively, elicits a reduction in cold defense mechanisms demonstrated through higher skin temperatures, attenuated shivering, and reduced cold sensations. These habituated responses likely serve to preserve peripheral tissue temperature and conserve energy during non-life threatening cold stress. The purpose of this review is to define habituation in general terms, present evidence for the response in non-human species, and provide an up-to-date, critical examination of past studies and the potential physiological mechanisms underlying human cold habituation. Our aim is to stimulate interest in this area of study and promote further experiments to understand this physiological adaptation.

习惯化是在许多生物体中看到的一种适应,通过减少对重复刺激的反应来定义。从进化的角度来看,习惯化被认为是有益的,因为它允许代谢资源的保存,否则代谢资源会被用于亚致命的挑衅,包括反复的寒冷暴露。高代谢和/或保温适应可能在长时间和严重的寒冷暴露后发生,分别导致增强的冷防御机制,如产热增加和外周血管收缩。习惯化发生在这些适应之前,是对短时间轻度寒冷暴露的反应,并且,也许与直觉相反,引起了通过更高的皮肤温度,减弱的颤抖和减少的寒冷感觉来证明的寒冷防御机制的减少。这些习惯反应可能有助于在不危及生命的冷应激下保持外周组织温度和保存能量。本综述的目的是概括地定义习惯化,为非人类物种的反应提供证据,并对过去的研究和人类冷习惯的潜在生理机制提供最新的批判性检查。我们的目的是激发人们对这一研究领域的兴趣,并促进进一步的实验来理解这种生理适应。
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引用次数: 11
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