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Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2020-11-17 eCollection Date: 2020-01-01 DOI: 10.1080/23328940.2020.1844428
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引用次数: 0
Enhancing quality in preclinical data: Of hot science and cool quality. 提高临床前数据的质量:热科学与冷质量。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2020-09-02 eCollection Date: 2020-01-01 DOI: 10.1080/23328940.2020.1801133
Anton Bespalov, Christoph Emmerich, Björn Gerlach
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引用次数: 0
Effects of exercise-heat stress on circulating stress hormones and interleukin-6 in young and older men. 运动-热应激对青年和老年男性循环应激激素和白细胞介素-6的影响。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2020-05-24 eCollection Date: 2020-01-01 DOI: 10.1080/23328940.2020.1768032
Antonia Kaltsatou, Sean R Notley, Glen P Kenny

Aging is associated with impairments in thermoregulatory function, which may augment the neuroendocrine and immune response in older relative to young adults during physical activity in the heat. This study was therefore aimed at examining changes in circulating endocrine hormones as cortisol (COR), prolactin (PRL), human growth hormone (hGH) and interleukin-6 (IL-6) in young and older men prior to and following an incremental, exercise-heat stress protocol (40°C and ~15% relative humidity). Accordingly, ten habitually active young (mean±SD; 21 ± 1 years) and ten older (65 ± 3 years) men performed three 30-min bouts of cycling at increasing metabolic heat productions (300, 400 and 500 W, equal to light, moderate and vigorous exercise), each separated by a 15-min recovery. Consistent with our hypothesis, we observed augmented IL-6 in older (3.55 ± 1.62 pg/mL) compared to young men (1.59 ± 0.88 pg/mL) following the protocol (p < 0.001). However, no significant between-group differences were observed for COR and hGH (all p > 0.050). We show that when assessed following incremental exercise in the heat, older men display augmented interleukin-6, but similar levels of stress hormones relative to young men.

衰老与体温调节功能受损有关,这可能会增强老年人在高温下进行身体活动时的神经内分泌和免疫反应。因此,本研究旨在检查年轻和老年男性在增量运动-热应激方案(40°C和~15%相对湿度)之前和之后循环内分泌激素的变化,如皮质醇(COR)、催乳素(PRL)、人类生长激素(hGH)和白细胞介素-6 (IL-6)。相应地,10名习惯性运动的年轻人(mean±SD;21±1岁)和10名年龄较大(65±3岁)的男性在增加代谢热(300、400和500 W,等于轻度、中度和剧烈运动)的情况下进行三次30分钟的自行车运动,每次间隔15分钟的恢复。与我们的假设一致,我们观察到老年男性的IL-6水平(3.55±1.62 pg/mL)高于年轻男性(1.59±0.88 pg/mL) (p 0.050)。我们表明,当在高温下进行增量运动后进行评估时,老年男性的白细胞介素-6增加,但与年轻男性相比,压力激素水平相似。
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引用次数: 1
Effects of temperature on feeding and digestive processes in fish. 温度对鱼类摄食和消化过程的影响。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2020-05-18 eCollection Date: 2020-01-01 DOI: 10.1080/23328940.2020.1765950
Helene Volkoff, Ivar Rønnestad

As most fish are ectotherms, their physiology is strongly affected by temperature. Temperature affects their metabolic rate and thus their energy balance and behavior, including locomotor and feeding behavior. Temperature influences the ability/desire of the fish to obtain food, and how they process food through digestion, absorb nutrients within the gastrointestinal tract, and store excess energy. As fish display a large variability in habitats, feeding habits, and anatomical and physiological features, the effects of temperature are complex and species-specific. The effects of temperature depend on the timing, intensity, and duration of exposure as well as the speed at which temperature changes occur. Whereas acute short-term variations of temperature might have drastic, often detrimental, effects on fish physiology, long-term gradual variations might lead to acclimation, e.g. variations in metabolic and digestive enzyme profiles. The goal of this review is to summarize our current knowledge on the effects of temperature on energy homeostasis, with specific focus on metabolism, feeding, digestion, and how fish are often able to "adapt" to changing environments through phenotypic and physiological changes.

由于大多数鱼类是变温动物,它们的生理受到温度的强烈影响。温度影响它们的代谢率,从而影响它们的能量平衡和行为,包括运动和摄食行为。温度影响鱼类获取食物的能力/欲望,以及它们如何通过消化处理食物、在胃肠道内吸收营养和储存多余能量。由于鱼类在栖息地、摄食习性、解剖和生理特征上表现出很大的可变性,温度的影响是复杂的,而且是物种特异性的。温度的影响取决于曝光的时间、强度和持续时间,以及温度变化发生的速度。短期的剧烈温度变化可能对鱼类生理产生剧烈的、往往是有害的影响,而长期的逐渐变化可能导致适应,例如代谢和消化酶谱的变化。这篇综述的目的是总结我们目前对温度对能量稳态影响的认识,特别关注代谢、摄食、消化,以及鱼类如何通过表型和生理变化“适应”不断变化的环境。
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引用次数: 126
Assessing the risk of acute kidney injury following exercise in the heat: Timing is important: Comment on: Chapman, C.L., Johnson, B.D., Vargas, N.T., Hostler, D, Parker, M.D., and Schlader, Z.J. Hyperthermia and dehydration during physical work in the heat both contribute to the risk of acute kidney injury, J Appl Physiol (1985), 2020. DOI: https://doi.org/10.1152/japplphysiol.00787.2019. 评估高温运动后急性肾损伤的风险:时机很重要:评论:Chapman, c.l., Johnson, b.d., Vargas, n.t., Hostler, D, Parker, m.d., and Schlader, Z.J.高温下体力工作期间的高温和脱水都会导致急性肾损伤的风险,《苹果物理杂志》(1985),2020。DOI: https://doi.org/10.1152/japplphysiol.00787.2019。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2020-03-21 eCollection Date: 2020-01-01 DOI: 10.1080/23328940.2020.1741333
Christopher L Chapman, Zachary J Schlader
There has been a surge of studies published in the last 10 y examining the potential for pathology related to exercise (or physical work) in the heat and the kidneys. For instance, a PubMed search ...
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引用次数: 2
Heat acclimation attenuates the increased sensations of fatigue reported during acute exercise-heat stress. 热适应可减轻急性运动热应激时所报告的疲劳感的增加。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2019-09-19 DOI: 10.1080/23328940.2019.1664370
Ashley G B Willmott, Mark Hayes, Carl A James, Oliver R Gibson, Neil S Maxwell

Athletes exercising in heat stress experience increased perceived fatigue acutely, however it is unknown whether heat acclimation (HA) reduces the magnitude of this perceptual response and whether different HA protocols influence the response. This study investigated sensations of fatigue following; acute exercise-heat stress; short- (5-sessions) and medium-term (10-sessions) HA; and between once- (ODHA) and twice-daily HA (TDHA) protocols. Twenty male participants (peak oxygen uptake: 3.75 ± 0.47 L·min-1) completed 10 sessions (60-min cycling at ~2 W·kg-1, 45°C/20% relative humidity) of ODHA (n = 10) or non-consecutive TDHA (n = 10). Sensations of fatigue (General, Physical, Emotional, Mental, Vigor and Total Fatigue) were assessed using the multi-dimensional fatigue scale inventory-short form pre and post session 1, 5 and 10. Heat adaptation was induced following ODHA and TDHA, with reductions in resting rectal temperature and heart rate, and increased plasma volume and sweat rate (P < 0.05). General, Physical and Total Fatigue increased from pre-to-post for session 1 within both groups (P < 0.05). Increases in General, Physical and Total Fatigue were attenuated in session 5 and 10 vs. session 1 of ODHA (P < 0.05). This change only occurred at session 10 of TDHA (P < 0.05). Whilst comparative heat adaptations followed ODHA and TDHA, perceived fatigue is prolonged within TDHA.

Abbreviations: ∆: Change; ANOVA: Analysis of variance; HA: Heat acclimation; HR: Heart rate; IL-6: Interleukin-6; MFS-SF: Multi-dimensional fatigue symptom inventory-short form (MFSI-SF); MTHA: Medium-term heat acclimation; Na+: Sodium; ODHA: Once daily heat acclimation; PV: Plasma volume; RH: Relative humidity; RPE: Rating of perceived exertion; SD: Standard deviation; SE: Standard error of the slope coefficient or intercept; SEE : Standard error of the estimate for the regression equation; STHA: Short-term heat acclimation; TDHA: Twice daily heat acclimation; TC: Thermal Comfort; Tre: Rectal temperature; TSS: Thermal sensation; V̇O2peak: Peak oxygen uptake; WBSL: whole-body sweat loss.

在热应激中运动的运动员会在急性期感到疲劳加剧,但热适应(HA)是否会降低这种知觉反应的程度,以及不同的热适应方案是否会影响这种反应,目前尚不清楚。本研究调查了急性运动热应激、短期(5 次)和中期(10 次)HA 以及一次(ODHA)和两次(TDHA)HA 方案之间的疲劳感觉。20 名男性参与者(峰值摄氧量:3.75 ± 0.47 L-min-1)完成了 10 次 ODHA(n = 10)或非连续 TDHA(n = 10)疗程(在约 2 W-kg-1 条件下骑车 60 分钟,相对湿度 45°C/20%)。在第 1、5 和 10 次训练前后,使用多维疲劳量表短表对疲劳感觉(一般疲劳、身体疲劳、情绪疲劳、精神疲劳、活力疲劳和总疲劳)进行评估。在 ODHA 和 TDHA 之后,热适应被诱导出来,静息直肠温度和心率降低,血浆容量和出汗率增加(P 缩写:∆:变化;ANOVA:方差分析;HA:热适应;HR:心率;IL-6:白细胞介素-6;MFS-SF:多维疲劳症状清单-简表(MFSI-SF);MTHA:中期热适应;Na+:钠;ODHA:每日一次热适应;PV:血浆容量;RH:相对湿度;RPE:感知用力评分;SD:心率:SD:标准偏差;SE:斜率系数或截距的标准误差;SEE:回归方程估计值的标准误差;STHA:短期热适应;TDHA:每日两次热适应;TC:热舒适;Tre:直肠温度;TSS:体温:直肠温度;TSS:热感觉;V......峰值摄氧量:峰值摄氧量;WBSL:全身出汗量。
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引用次数: 0
Heat-induced hypervolemia: Does the mode of acclimation matter and what are the implications for performance at Tokyo 2020? 热致高血容量:适应方式重要吗?对2020年东京奥运会的表现有什么影响?
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2019-09-03 DOI: 10.1080/23328940.2019.1653736
Lorenz S Kissling, Ashley P Akerman, James D Cotter
ABSTRACT Tokyo 2020 will likely be the most heat stressful Olympics to date, so preparation to mitigate the effects of humid heat will be essential for performance in several of the 33 sports. One key consideration is heat acclimation (HA); the repeated exposure to heat to elicit physiological and psychophysical adaptations that improve tolerance and exercise performance in the heat. Heat can be imposed in various ways, including exercise in the heat, hot water immersion, or passive exposure to hot air (e.g., sauna). The physical requirements of each sport will determine the impact that the heat has on performance, and the adaptations required from HA to mitigate these effects. This review focuses on one key adaptation, plasma volume expansion (PVE), and how the mode of HA may affect the kinetics of adaptation. PVE constitutes a primary HA-mediated adaptation and contributes to functional adaptations (e.g., lower heart rate and increased heat loss capacity), which may be particularly important in athletes of “sub-elite” cardiorespiratory fitness (e.g., team sports), alongside athletes of prolonged endurance events. This review: i) highlights the ability of exercise in the heat, hot-water immersion, and passive hot air to expand PV, providing the first quantitative assessment of the efficacy of different heating modes; ii) discusses how this may apply to athletes at Tokyo 2020; and iii) provides recommendations regarding the protocol of HA and the prospect for achieving PVE (and the related outcomes).
2020年东京奥运会可能是迄今为止最炎热的一届奥运会,因此准备减轻湿热的影响对33个项目中的几个项目的表现至关重要。一个关键的考虑因素是热驯化(HA);反复暴露在高温中,以引起生理和心理物理适应,提高耐受性和在高温下的运动表现。热量可以通过各种方式施加,包括在高温下运动,热水浸泡,或被动暴露在热空气中(例如,桑拿)。每项运动的体能要求将决定热量对运动表现的影响,以及HA对减轻这些影响的适应性要求。这篇综述着重于一个关键的适应,血浆体积膨胀(PVE),以及HA的模式如何影响适应动力学。PVE构成了主要的ha介导的适应,并有助于功能适应(例如,较低的心率和增加的热损失能力),这在“亚精英”心肺健康运动员(例如,团队运动)以及长时间耐力项目的运动员中可能特别重要。这篇综述:i)强调了在高温下运动、热水浸泡和被动热空气对PV的扩张能力,首次对不同加热模式的功效进行了定量评估;ii)讨论这如何适用于2020年东京奥运会的运动员;iii)提供关于HA协议和实现PVE的前景(以及相关结果)的建议。
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引用次数: 15
Fan cooling after cardiovascular drift does not reverse decrements in maximal oxygen uptake during heat stress 心血管漂移后的风扇冷却不能逆转热应激期间最大摄氧量的下降
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2019-07-03 DOI: 10.1080/23328940.2019.1657344
J. Wingo, Jason Ng, C. Katica, S. Carter
ABSTRACT Cardiovascular (CV) drift, the progressive increase in heart rate (HR) and decrease in stroke volume (SV) during constant rate, moderate intensity exercise, is related to reduced maximal oxygen uptake (V̇O2max) during heat stress. Once it has already occurred, it is unknown whether the detrimental effects of CV drift on V̇O2max can be reversed. This study tested the hypothesis that fan cooling after CV drift has occurred attenuates decrements in V̇O2max associated with CV drift. Eight men completed a control graded exercise test (GXT) in 22°C to measure V̇O2max. Then on separate, counterbalanced occasions, they completed one 15-min (15MIN) and two 45-min bouts (45NF and 45FAN) of cycling in 35°C, 40% RH at 60% V̇O2max, each immediately followed by a GXT to measure V̇O2max. For one of the 45-min trials (45FAN), fan airflow (4.5 m/s) was directed at participants beginning ~5 min before the GXT and continuing throughout the remainder of exercise. The purpose of the separate 15- and 45-min trials was to measure V̇O2max during the same time interval that CV drift occurred. HR increased (13.8% and 11.4%) and SV decreased (14.4% and 14.1%) for 45NF and 45FAN, respectively; trials were not different (all P > 0.05). Despite a decrease in mean skin temperature of ~1°C with fan use, V̇O2max decreased similarly between conditions (17% vs. 15% for 45NF and 45FAN, P = 0.54). Fan cooling after CV drift was insufficient to reverse the negative consequences of CV drift on V̇O2max after prolonged exercise in a hot environment. Abbreviations: 15MIN: 15-min trial; 45FAN: 45-min, fan trial; 45NF: 45-min, no fan trial; ANOVA: Analysis of variance; CV: Cardiovascular; GXT: Graded exercise test; HR: Heart rate; SV: Stroke volume; T̅b: Mean body temperature; Tre: Rectal temperature; T̅sk: Mean skin temperature; V̇O2max: Maximal oxygen uptake
摘要心血管(CV)漂移,即在恒速中等强度运动中心率(HR)的逐渐增加和射血容量(SV)的降低,与热应激期间最大摄氧量(V̇O2max)的降低有关。一旦已经发生,就不知道CV漂移对V̇O2max的有害影响是否可以逆转。本研究验证了这样一种假设,即CV漂移发生后的风扇冷却会减弱与CV漂移相关的V̇O2max的下降。8名男性在22°C下完成了对照分级运动测试(GXT),以测量V̇O2max。然后,在不同的、平衡的情况下,他们在35°C、40%RH、60%V̇O2max下完成了一次15分钟(15MIN)和两次45分钟(45NF和45FAN)的循环,每次循环后立即进行GXT测量V 775 O2max。对于其中一项45分钟的试验(45FAN),从GXT前约5分钟开始,将风扇气流(4.5 m/s)引导至参与者,并在剩余的运动中持续进行。单独的15分钟和45分钟试验的目的是在CV漂移发生的相同时间间隔内测量V̇O2max。45NF和45FAN的HR分别升高(13.8%和11.4%)和SV分别降低(14.4%和14.1%);试验没有差异(均P>0.05)。尽管使用风扇可使平均皮肤温度降低约1°C,但V̇O2max在不同条件下的下降相似(45NF和45FAN分别为17%和15%,P=0.54)。CV漂移后的风扇冷却不足以逆转在高温环境下长时间运动后CV漂移对V 775 O2max的负面影响。缩写:15MIN:15分钟试用;45FAN:45分钟,风扇试验;45NF:45分钟,无风扇试验;方差分析:方差分析;CV:心血管;GXT:分级运动测试;HR:心率;SV:行程量;Tõb:平均体温;Tre:直肠温度;Tõsk:平均皮肤温度;V̇O2max:最大摄氧量
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引用次数: 4
About the cover 关于封面
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2019-07-03 DOI: 10.1080/23328940.2019.1665795
P. Leboit
Granuloma faciale is a diagnosis that is often overlooked clinically and by general pathologists. My experience is that clinicians often stumble into the diagnosis. There is usually only one lesion, so that their suspicion is of a neoplasm rather than of an inflammatory condition. General pathologists often do not know of the condition or remember it. This makes it a satisfying diagnosis for dermatopathologists to make. Granuloma faciale is also one of those wonderful misnomers in dermatology. The term “granuloma” reflects a clinical appearance suggesting granules, as is the case in granuloma pyogenicum and granuloma gluteale infantum, other diseases in which granulomatous inflammation does not normally occur. Lesions of granuloma faciale are seldom biopsied at an early stage. That is why the findings in an early lesion (Fig. 1, and on the cover) are worth looking at in detail. The condition is a small vessel leukocytoclastic vasculitis, but not a conventional one. There is fibrin in the walls of vessels, and neutrophils and their dust around them in both conditions. Unlike conventional leukocytoclastic vasculitis, the amount of neutrophilic nuclear dust is scant, and extravasated erythrocytes are few. The infiltrates evidently become much denser than in conventional leukocytoclastic vasculitis rather quickly. The changes that make granuloma faciale more distinctive develop with time. In addition to dense infiltrates of neutrophils, eosinophils, and plasma cells, fibrosis supervenes, often oriented concentrically around small vessels (Fig. 2). The lesions of granuloma faciale are typically solitary facial plaques (Fig. 3). They can be extraordinarily long lasting and resistant to treatment, although there have been recent reported successes with laser therapy (1). Ackerman and Mones recently briefly stated their position that granuloma faciale and erythema elevate diutinum are “different names for the same condition, namely, longstanding leukocytoclastic vasculitis on different sites, the face for the former and the extremities for the latter” (2). I believe that they are two distinct diseases. Patients with plaques of granuloma faciale on their faces may develop extrafacial granuloma faciale, but not in a symmetrical manner (3–5). Extrafacial granuloma faciale can occur without lesions on the face, although most occur with them. There is a peculiar condition, angiocentric eosinophilic fibrosis of the larynx, which can accompany granuloma faciale (6). The histopathology of extrafacial granuloma faciale (including its laryngeal variant) is similar to that of facial lesions. Erythema elevatum diutinum begins, like granuloma faciale, with neutrophils and neutrophilic nuclear dust around small vessels that have fibrin in their wall (7). The sites of predilection are different—the face is usually spared, and the skin on the dorsal aspects of joints is usually the target. The eruption is bilateral and symmetric in most cases, sometimes startlingly so (
面部肉芽肿是一种诊断,往往被忽视的临床和一般病理学家。我的经验是,临床医生经常会在诊断中出错。通常只有一个病变,因此他们怀疑是肿瘤而不是炎症。一般的病理学家通常不知道或不记得这种情况。这使得皮肤病理学家可以做出令人满意的诊断。面部肉芽肿也是皮肤病学中一个美妙的用词不当。“肉芽肿”一词反映了临床表现为颗粒状,如化脓性肉芽肿和婴儿臀肉芽肿,以及其他通常不发生肉芽肿性炎症的疾病。面部肉芽肿的病变很少在早期进行活检。这就是为什么早期病变的发现(图1和封面)值得详细研究的原因。这种情况是一种小血管白细胞破裂性血管炎,但不是常规的。在这两种情况下,血管壁上都有纤维蛋白,周围都有中性粒细胞和它们的灰尘。与常规的白细胞破壁性血管炎不同,中性粒细胞核尘较少,外渗红细胞较少。浸润明显比常规白细胞破壁性血管炎更致密。使面部肉芽肿更加明显的变化随着时间的推移而发展。除了中性粒细胞、嗜酸性粒细胞和浆细胞的密集浸润外,还会出现纤维化,通常集中在小血管周围(图2)。面部肉芽肿的病变通常是孤立的面部斑块(图3)。它们可能持续很长时间,且对治疗有耐药性。尽管最近有报道称激光治疗取得了成功(1)。Ackerman和Mones最近简要地阐述了他们的观点,即面部肉芽肿和升尿性红斑是“同一种疾病的不同名称,即不同部位的长期白细胞破坏性血管炎,前者为面部,后者为四肢”(2)。我认为它们是两种不同的疾病。面部有肉芽肿斑块的患者可能会出现面外肉芽肿,但不是对称的(3-5)。面外肉芽肿可以在面部无病变的情况下发生,尽管大多数与病变同时发生。有一种特殊的情况,即喉部血管中心性嗜酸性粒细胞纤维化,可伴有面部肉芽肿(6)。面部外肉芽肿(包括其喉部变型)的组织病理学与面部病变相似。与面部肉芽肿一样,膨升性红斑开始时,中性粒细胞和中性粒细胞核尘围绕在壁内有纤维蛋白的小血管周围(7)。偏爱的部位不同——面部通常不受影响,关节背侧的皮肤通常是目标。大多数情况下,皮疹是双侧对称的,有时是惊人的对称(图4)。与面部肉芽肿相比,病变可以变得更加突出。有许多病例与全身性疾病相关,但与之相关的面部肉芽肿病例要少得多(8)。组织病理学上,嗜酸性粒细胞很少或不存在,中性粒细胞占多数,浆细胞只是偶尔出现。diutinum隆起性红斑的大结节通常具有独特的纤维化模式(长,平行排列的胶原束和散布的中性粒细胞),这是面部肉芽肿的旧病变所没有的(图5)(9)。可以肯定的是,这些疾病是同一家族的成员,但并不相同。来自加州大学旧金山分校病理与皮肤学系。地址通信和转载请求Philip E. LeBoit,医学博士,皮肤病理科,加州大学旧金山分校,1701 Divisadero街,350室,旧金山,CA 94115美国E-mail: philipl@itsa.ucsf.edu美国皮肤病理学杂志24(5):440-443,2002©2002 Lippincott Williams & Wilkins, Inc.,费城
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引用次数: 0
Hand and torso pre-cooling does not enhance subsequent high-intensity cycling or cognitive performance in heat. 手部和躯干的预冷并不能提高随后的高强度骑行或在高温下的认知能力。
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2019-06-25 DOI: 10.1080/23328940.2019.1631731
Tessa Maroni, Brian Dawson, Grant Landers, Louise Naylor, Karen Wallman

The purpose of this study was to compare the separate and combined effects of two practical cooling methods (hand and torso) used prior to exercise on subsequent high-intensity cycling performance in heat. Ten trained male cyclists (V̇O2peak: 65.7 ± 10.7 ml.kg-1.min-1) performed four experimental trials (randomised within-subjects design) involving 30-min of pre-cooling (20-min seated; PRE-COOL, 10 min warm-up; PRE-COOL+WUP), while using a: (1) hand-cooling glove (CG); (2) cooling jacket (CJ); (3) both CG and CJ (CG+J); or (4) no-cooling (NC) control, followed by a cycling race simulation protocol (all performed in 35.0 ± 0.6°C and 56.6 ± 4.5% RH). During the 30-min of pre-cooling, no reductions in core (Tc) or mean skin temperature (Tsk) occurred; however, Tsk remained lower in the CJ and CG+J trials compared to NC and CG (p = 0.002-0.040, d= 0.55-1.01). Thermal sensation ratings also indicated that participants felt "hotter" during NC compared to all other trials during both PRE-COOL and PRE-COOL+WUP (p = 0.001-0.015, d= 1.0-2.19), plus the early stages of exercise (sets 1-2; p = 0.005-0.050, d= 0.56-1.22). Following cooling, no differences were found for absolute Tc and Tsk responses between trials over the entire exercise protocol (p > 0.05). Exercise and cognitive (working memory) performance also did not differ between trials (p = 0.843); however, cognitive performance improved over time in all trials (p < 0.001). In summary, pre-cooling (20-min seated and 10-min warm-up) in heat did not improve subsequent high-intensity cycling performance, cognitive responses and associated thermoregulatory strain (Tc and Tsk) compared to control.

本研究旨在比较运动前使用两种实用冷却方法(手部和躯干)对随后高温下高强度自行车运动表现的单独和综合影响。十名训练有素的男性自行车运动员(V̇O2peak:65.7 ± 10.7 ml.kg-1.min-1)进行了四次实验(随机受试者内设计),包括 30 分钟的预冷(20 分钟坐姿;PRE-COOL,10 分钟热身;PRE-COOL+WUP),同时使用以下工具:(1) 手部冷却手套(CG);(2) 手部冷却手套(CG);(3) 手部冷却手套(CG):(1) 手部冷却手套 (CG);(2) 冷却夹克 (CJ);(3) CG 和 CJ(CG+J);或 (4) 无冷却 (NC) 对照组,然后进行自行车模拟比赛(所有比赛均在 35.0 ± 0.6°C 和 56.6 ± 4.5% 相对湿度条件下进行)。在 30 分钟的预冷过程中,核心温度(Tc)或平均皮肤温度(Tsk)没有降低;但是,与 NC 和 CG 相比,CJ 和 CG+J 试验中的 Tsk 仍然较低(p = 0.002-0.040,d= 0.55-1.01)。热感觉评级还表明,在冷却前和冷却前+WUP(p = 0.001-0.015,d= 1.0-2.19)以及运动初期(第 1-2 组;p = 0.005-0.050,d= 0.56-1.22),NC 试验中参与者的热感觉比所有其他试验都要 "热"。冷却后,在整个运动方案中,试验之间的绝对 Tc 和 Tsk 反应没有发现差异(p > 0.05)。不同试验之间的运动和认知(工作记忆)表现也没有差异(p = 0.843);但是,随着时间的推移,所有试验的认知表现都有所改善(p < 0.001)。总之,与对照组相比,在高温下进行预冷(20 分钟坐姿和 10 分钟热身)并不能提高随后的高强度自行车运动成绩、认知反应和相关体温调节应变(Tc 和 Tsk)。
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