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Thermal phantom sensations in arm amputees and what it means for future prosthetics 手臂截肢者的热幻觉及其对未来假肢的意义
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-02-25 DOI: 10.1080/23328940.2023.2262144
S. Shokur, Silvestro Micera
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引用次数: 0
Precooling via immersion in CO 2 -enriched water at 25°C decreased core body temperature but did not improve 10-km cycling time trial in the heat 通过在 25°C 富含 CO 2 的水中浸泡进行预冷可降低核心体温,但并不能改善高温下 10 公里自行车计时赛的成绩
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-28 DOI: 10.1080/23328940.2024.2302772
Luthfil Aidiel, Darren Z. Y. Lim, Kin M. Chow, Mohammed Ihsan, M. Chia, H. Choo
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引用次数: 0
Mechanism involved of post-exercise cold water immersion: Blood redistribution and increase in energy expenditure during rewarming 运动后冷水浸泡的相关机制:血液再分布和回温过程中能量消耗的增加
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-15 DOI: 10.1080/23328940.2024.2303332
Dorian Giraud, L. Pomportes, Caroline Nicol, Denis Bertin, Jean-Laurent Gardarein, Arnaud Hays
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引用次数: 0
Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence. 环境诱导的高温老年人的实验研究:绘制现有证据的系统定量文献综述
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-02 Epub Date: 2023-08-27 DOI: 10.1080/23328940.2023.2242062
Aaron J E Bach, Sarah J K Cunningham, Norman R Morris, Zhiwei Xu, Shannon Rutherford, Sebastian Binnewies, Robert D Meade

The heat-related health burden is expected to persist and worsen in the coming years due to an aging global population and climate change. Defining the breadth and depth of our understanding of age-related changes in thermoregulation can identify underlying causes and strategies to protect vulnerable individuals from heat. We conducted the first systematic quantitative literature review to provide context to the historical experimental research of healthy older adults - compared to younger adults or unhealthy age matched cases - during exogenous heat strain, focusing on factors that influence thermoregulatory function (e.g. co-morbidities). We identified 4,455 articles, with 147 meeting eligibility criteria. Most studies were conducted in the US (39%), Canada (29%), or Japan (12%), with 71% of the 3,411 participants being male. About 71% of the studies compared younger and older adults, while 34% compared two groups of older adults with and without factors influencing thermoregulation. Key factors included age combined with another factor (23%), underlying biological mechanisms (18%), age independently (15%), influencing health conditions (15%), adaptation potential (12%), environmental conditions (9%), and therapeutic/pharmacological interventions (7%). Our results suggest that controlled experimental research should focus on the age-related changes in thermoregulation in the very old, females, those with overlooked chronic heat-sensitive health conditions (e.g. pulmonary, renal, mental disorders), the impact of multimorbidity, prolonged and cumulative effects of extreme heat, evidence-based policy of control measures (e.g. personal cooling strategies), pharmaceutical interactions, and interventions stimulating protective physiological adaptation. These controlled studies will inform the directions and use of limited resources in ecologically valid fieldwork studies.

由于全球人口老龄化和气候变化,预计未来几年与热有关的健康负担将持续存在并不断加重。确定我们对与年龄相关的体温调节变化的理解的广度和深度,可以找出根本原因,并确定保护易感人群免受高温影响的策略。我们进行了首次系统性定量文献综述,为健康老年人在外源性热应变期间与年轻成年人或不健康的年龄匹配病例的历史实验研究提供背景资料,重点关注影响体温调节功能的因素(如并发症)。我们确定了 4455 篇文章,其中 147 篇符合资格标准。大多数研究在美国(39%)、加拿大(29%)或日本(12%)进行,3411 名参与者中有 71% 为男性。约 71% 的研究对年轻人和老年人进行了比较,34% 的研究对两组有和没有影响体温调节因素的老年人进行了比较。主要因素包括年龄与其他因素的结合(23%)、潜在的生物机制(18%)、独立的年龄(15%)、影响健康的条件(15%)、适应潜力(12%)、环境条件(9%)以及治疗/药物干预(7%)。我们的研究结果表明,对照实验研究应重点关注高龄老人、女性、对热敏感的慢性疾病(如肺病、肾病、精神疾病)患者体温调节方面与年龄有关的变化、多病症的影响、极端高温的长期和累积效应、循证控制措施政策(如个人降温策略)、药物相互作用以及刺激保护性生理适应的干预措施。这些对照研究将为生态学上有效的实地研究的方向和有限资源的使用提供信息。
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引用次数: 0
The effect of hot water immersion on glucose tolerance: Differences between acute and chronic exposure. 热水浸泡对葡萄糖耐量的影响:急性和慢性接触的差异
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-06 eCollection Date: 2023-01-01 DOI: 10.1080/23328940.2023.2190727
Brett R Ely, Zachary S Clayton, Christopher T Minson
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引用次数: 0
About the Cover. 关于封面
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-06 eCollection Date: 2023-01-01 DOI: 10.1080/23328940.2023.2270304
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引用次数: 0
Pain and temperature, and human awareness: The legacy of Bud Craig. 疼痛和温度,以及人类的意识:巴德-克雷格的遗产
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-06 eCollection Date: 2023-01-01 DOI: 10.1080/23328940.2023.2265946
Anders Blomqvist
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引用次数: 0
Consumption of hot protein-containing drink accelerates gastric emptying rate and is associated with higher hunger levels in older adults 饮用含蛋白质的热饮可加快胃排空速度,并与老年人饥饿感增加有关
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-11-19 DOI: 10.1080/23328940.2023.2278410
Kyoko Fujihira, Masaki Takahashi, Chunyi Wang, Saeka Fuke, Naoyuki Hayashi
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引用次数: 0
Living in Western Australia induces some physiological and perceptual adaptations of seasonal acclimatization in the surgical burns team 生活在西澳大利亚诱发一些生理和知觉适应的季节适应外科烧伤团队
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-11-07 DOI: 10.1080/23328940.2023.2281210
Zehra Palejwala, Karen E. Wallman, Grant J. Landers, Prashan Anbalagan, Fiona M. Wood, Shane K. Maloney
ABSTRACTSeasonal acclimatization is known to result in adaptations that can improve heat tolerance. Staff who operate on burn injuries are exposed to thermally stressful conditions and seasonal acclimatization may improve their thermoeffector responses during surgery. Therefore, the aim of this study was to assess the physiological and perceptual responses of staff who operate on burn injuries during summer and winter, to determine whether they become acclimatized to the heated operating theater. Eight staff members had physiological and perceptual responses compared during burn surgeries conducted in thermoneutral (CON: 24.1 ± 1.2°C, 45 ± 7% relative humidity [RH]) and heated (HOT: 31.3 ± 1.6°C, 44 ± 7% RH) operating theaters, in summer and winter. Physiological parameters that were assessed included core temperature, heart rate, total sweat loss, sweat rate, and urinary specific gravity. Perceptual responses included ratings of thermal sensation and comfort. In summer CON compared to winter CON, baseline (85 ± 15 bpm VS 94 ± 18 bpm), mean (84 ± 16 bpm VS 93 ± 18 bpm), and peak HR (94 ± 17 bpm VS 105 ± 19 bpm) were lower (p < 0.05), whereas core temperature was not different between seasons in either condition (p > 0.05). In HOT, ratings of comfort were higher in summer (15 ± 3) than winter (13 ± 3; p > 0.05), but ratings of thermal sensation and sweat rate were similar between seasons (p > 0.05). The surgical team in burns in Western Australia can obtain some of the physiological and perceptual adaptations that result from seasonal acclimatization, but not all. That is most likely due to a lower than required amount of outdoor heat exposure in summer, to induce all physiological and perceptual adaptations.KEYWORDS: Seasonal acclimatizationburn surgeryadaptationsheat toleranceheat stresscore temperatureheart rateDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also. AcknowledgementsThe authors thank the burns team at Fiona Stanley Hospital for their participation and the Fiona Wood Foundation for their support with the research.ABBREVIATIONSHR=Heart rateIPAQ=International physical activity questionnaireMET=Metabolic equivalentOT=Operating theatrePPE=Personal protective equipmentRH=Relative humidityTBSA=Total body surface areaTC=Thermal comfortTcore=Core temperatureTS=Thermal sensationUSG=Urinary specific gravityWVP=Water vapour pressureDisclosure statementThe authors report there are no competing interests to declare.Data availabilityThe data that supports the findings of this study are available from the corresponding author [ZP] upon reasonable request.Fig 1. Seaso
在特定的时间点和特定的条件下,季节之间的效应大小中等到较大(g = 0.52 - 0.73)。所示的个人和平均数据。这项工作得到了菲奥娜·伍德基金会的支持
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引用次数: 0
Extracting thermodynamic properties from van ’t Hoff plots with emphasis on temperature-sensing ion channels 从范特霍夫图中提取热力学性质,重点是温度传感离子通道
Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-11-02 DOI: 10.1080/23328940.2023.2265962
Jakob T. Bullerjahn, Sonya M. Hanson
ABSTRACTTransient receptor potential (TRP) ion channels are among the most well-studied classes of temperature-sensing molecules. Yet, the molecular mechanism and thermodynamic basis for the temperature sensitivity of TRP channels remains to this day poorly understood. One hypothesis is that the temperature-sensing mechanism can simply be described by a difference in heat capacity between the closed and open channel states. While such a two-state model may be simplistic it nonetheless has descriptive value, in the sense that it can be used to compare overall temperature sensitivity between different channels and mutants. Here, we introduce a mathematical framework based on the two-state model to reliably extract temperature-dependent thermodynamic potentials and heat capacities from measurements of equilibrium constants at different temperatures. Our framework is implemented in an open-source data analysis package that provides a straightforward way to fit both linear and nonlinear van ’t Hoff plots, thus avoiding some of the previous, potentially erroneous, assumptions when extracting thermodynamic variables from TRP channel electrophysiology data.KEYWORDS: TRP channelstemperature sensorsvan ’t Hoff plotsthermodynamicsspline fitting AcknowledgmentsWe thank Dr. Andrés Jara-Oseguera for fruitful discussions and critical comments on the manuscript. The Flatiron Institute is a division of the Simons Foundation.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was supported by the Max-Planck-Gesellschaft (JTB) and the Simons Foundation (SMH).
瞬态受体电位(TRP)离子通道是被研究得最多的一类温度传感分子。然而,TRP通道温度敏感性的分子机制和热力学基础至今仍知之甚少。一种假设是,温度传感机制可以简单地描述为封闭和开放通道状态之间的热容量差异。虽然这种双态模型可能过于简单,但它仍然具有描述价值,因为它可以用于比较不同通道和突变体之间的总体温度敏感性。在这里,我们引入了一个基于双态模型的数学框架,以可靠地从不同温度下的平衡常数测量中提取与温度相关的热力学势和热容。我们的框架是在一个开源的数据分析软件包中实现的,该软件包提供了一种直接的方法来拟合线性和非线性范特霍夫图,从而避免了从TRP通道电生理数据中提取热力学变量时的一些先前可能错误的假设。关键词:TRP通道,温度传感器,van ' t Hoff图,热力学样条拟合感谢我们感谢andr Jara-Oseguera博士对本文进行的富有成效的讨论和重要的评论。熨斗研究所是西蒙斯基金会的一个部门。披露声明作者未报告潜在的利益冲突。本研究得到了马克斯-普朗克协会(JTB)和西蒙斯基金会(SMH)的支持。
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Temperature
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