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Practical Analysis of Tap Water Dissolved Solids Efficient Reduction 自来水溶解固形物有效还原的实践分析
Q4 Physics and Astronomy Pub Date : 2023-09-12 DOI: 10.53560/ppasa(60-3)799
None Muhammad Imran Majid, None Naeem Shahzad
Water is an essential component in the manufacturing of oral solid dosage forms in the pharmaceutical industry. The objective of the present study is to develop a compact and easy-to-maintain one-platform solution for generating high-purity water with near to zero Total Dissolved Solids (TDS) and low conductivity for pharmaceutical applications. To achieve this objective, different purification methods were explored and integrated into a single platform. The purification process involved the use of Electro-Deionization (EDI) in combination with double-pass Reverse Osmosis (RO), an activated carbon filter, water softeners, and micron filtration. The resource water was carefully selected based on specific criteria to ensure the quality of the final purified water. The developed one-platform solution successfully produced purified water with near to zero TDS and a conductivity level below 1 micro siemens/cm2. The integrated approach involving EDI and double-pass RO, along with supplementary filtration and treatment steps, proved to be highly effective in achieving the desired purity levels. The study demonstrated that the suggested one-platform solution is a reliable and efficient method for the production of high-purity water in the pharmaceutical industry. This system offers an easily maintainable and compact solution, making it suitable for various other industries such as semiconductor manufacturing and electric power generation where purified water with zero TDS is required. By providing a robust water purification process, this solution contributes to enhancing the quality and safety of pharmaceutical products and other critical applications that rely on ultra-pure water.
水是制药业生产口服固体剂型的重要成分。本研究的目的是开发一种紧凑且易于维护的单一平台解决方案,用于生产接近零总溶解固体(TDS)和低电导率的高纯度水,用于制药应用。为了实现这一目标,我们探索了不同的净化方法,并将其整合到一个平台上。净化过程包括使用电去离子(EDI)与双向反渗透(RO)、活性炭过滤器、水软化剂和微米过滤相结合。根据特定的标准精心选择资源水,以确保最终纯化水的质量。开发的单平台解决方案成功地生产出了TDS接近于零、电导率低于1微西门子/平方厘米的纯净水。综合方法包括EDI和双向反渗透,以及补充过滤和处理步骤,证明在达到所需纯度水平方面非常有效。研究表明,建议的单平台解决方案是一种可靠而有效的方法,用于制药工业生产高纯水。该系统提供了一个易于维护和紧凑的解决方案,使其适用于各种其他行业,如半导体制造和发电,这些行业需要零TDS的纯净水。通过提供强大的水净化过程,该解决方案有助于提高药品和其他依赖超纯水的关键应用的质量和安全性。
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引用次数: 0
Acoustical Analysis of Insertion Losses of Ceiling Materials 天花板材料插入损耗的声学分析
Q4 Physics and Astronomy Pub Date : 2023-09-10 DOI: 10.53560/ppasa(60-3)635
None Enobong Patrick Obot, None Rufus Chika Okoro, None Daniel Effiong Oku, None Christian Nlemchukwu Nwosu, None Michael Ugwu Onuu
This study concentrates on measuring, analyzing and recommending the ceiling materials most suited for the reduction of distinct frequency noise levels with focus on rain noise. A frequency analyzer has been used to measure and obtained accurate sound level (LP) data of the rain noise outside, and inside five buildings with diverse acoustical ceiling materials in South Eastern Nigeria. It was done with and without the ceiling partition (or noise barrier) for the audio and narrow frequency band without contribution from other outdoor-related noise sources. Insertion losses of the ceiling materials were calculated using the data obtained from the measured LP. Result obtained from the analysis indicated that the ceiling material found to effectively reduce the noise levels from external noise source. The type for speech reception threshold frequencies of more than 125 Hz and higher audiometric range was moabi wood with peak LP of 21.20 dB at 500 Hz. While for lower frequencies where the ears are least responsive was plaster of Paris (POP) with peak LP of 12.61 dB at 62.5 Hz. This makes “moabi wood” most suitable in lecture rooms, conference halls and large auditoriums as ceiling material, in consideration of its capability to provide notable attenuation of rain noise within the building. This is in accordance with several other studies done on this subject. In general, at much low frequencies and frequencies greater than 2k Hz significant reduction in the rain noise level was observed.
本研究的重点是测量、分析和推荐最适合降低不同频率噪音水平的天花板材料,重点是雨水噪音。使用频率分析仪测量并获得了尼日利亚东南部五座不同隔音天花板材料的建筑物内外雨噪声的准确声级(LP)数据。它是在没有天花板隔断(或隔音屏障)的情况下完成的,用于音频和窄频带,没有其他室外相关噪声源的贡献。利用测得的LP数据计算了天花板材料的插入损耗。分析结果显示,该吊顶材料可有效降低外界噪声源的噪音水平。语音接收阈值频率大于125 Hz和较高听阈范围的类型为moabi wood, 500 Hz时的峰值LP为21.20 dB。而对于较低频率,耳朵最不敏感的是巴黎石膏(POP),在62.5 Hz时,峰值LP为12.61 dB。这使得“摩阿比木”最适合在演讲室,会议厅和大型礼堂作为天花板材料,考虑到它在建筑物内提供显着衰减雨噪声的能力。这与关于这个主题的其他几项研究是一致的。一般来说,在较低的频率和大于2k赫兹的频率下,观察到雨水噪音水平显著降低。
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引用次数: 0
Blockchain in Healthcare: A Comprehensive Survey of Implementations and a Secure Model Proposal 区块链在医疗保健:实现的全面调查和安全模型建议
Q4 Physics and Astronomy Pub Date : 2023-09-05 DOI: 10.53560/ppasa(60-3)816
None Mehak Maqbool Memon, None Manzoor Ahmed Hashmani, None Filmann Taput Simpao, None Anthony Cinco Sales, None Neil Quinones Santillan, None Dodo Khan
Blockchain's core attributes, including decentralization, transparency, and immutability, have positioned it as a pioneering technology in the realm of financial technology (fintech) and have rendered it highly applicable across diverse industries. The current enterprise ecosystem has faced setbacks primarily due to a lack of trust in the existing infrastructure. This issue can be traced back to the centralized management of healthcare data, making it vulnerable to tampering and fraudulent activities, resulting in financial losses. The existing enterprise ecosystem failed due to the lack of trust in the currently in-place infrastructure. This problem can be attributed to the centralized healthcare data management, which is prone to tampering and fraudulent activities leading to capital loss. The present study relates to a comprehensive survey conducted in timespan from 2018 to 2022 on the implementation of blockchain technology in the healthcare industry, identifying and discussing the key challenges facing the healthcare industry, such as fraud, and scams against healthcare data. It is found that there is an enormous inclination towards the decentralization of patient-centric data. However, a rapid decline is reported due to the privacy and security concerns of the confidential and sensitive data. Moreover, it is noticed that most of the implementations utilized either Ethereum or Hyperledger. Based on the survey's findings, the study proposed a blockchain-based healthcare framework that can address the identified challenges by providing a secure and transparent platform for collecting, storing, and sharing patient health data while prioritizing security and privacy.
区块链的核心属性,包括去中心化、透明度和不变性,使其成为金融技术(fintech)领域的先驱技术,并使其高度适用于各个行业。当前的企业生态系统面临挫折,主要是由于对现有基础设施缺乏信任。这个问题可以追溯到医疗保健数据的集中管理,使其容易受到篡改和欺诈活动的影响,从而导致财务损失。由于对现有的基础设施缺乏信任,现有的企业生态系统失败了。这一问题可归因于集中式医疗保健数据管理,容易出现篡改和欺诈活动,导致资金损失。本研究涉及2018年至2022年期间对医疗保健行业实施区块链技术的全面调查,确定并讨论医疗保健行业面临的关键挑战,如欺诈和针对医疗保健数据的欺诈。研究发现,以病人为中心的数据有很大的分散化倾向。然而,由于机密和敏感数据的隐私和安全问题,据报道,这一数字正在迅速下降。此外,值得注意的是,大多数实现都使用了以太坊或超级账本。根据调查结果,该研究提出了一个基于区块链的医疗保健框架,该框架可以通过提供一个安全透明的平台来收集、存储和共享患者健康数据,同时优先考虑安全性和隐私性,从而解决已确定的挑战。
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引用次数: 0
Design and Development of Neutronics and Thermal Hydraulics Modeling Code for ACP1000 Nuclear Reactor Dynamics in LabVIEW ACP1000核反应堆动力学中子学和热工力学建模代码在LabVIEW中的设计与开发
Q4 Physics and Astronomy Pub Date : 2023-06-27 DOI: 10.53560/ppasa(60-2)781
Arshad Habib Malik, Feroza Arshad, Aftab Ahmad Memon
An advanced neutronics and thermal hydraulics nuclear code, called GNTHACP code, is designed and developed in LabVIEW as Graphical Neutronics and Thermal Hydraulics toolkit for 1100 MWe Advanced Chinese PWR (ACP-1000) nuclear power plant.  The reactor neutronics model is developed using a nonlinear point reactor kinetics model, while, the reactor thermal hydraulics model is developed based on nonlinear fuel and coolant temperature dynamics. The heart of the GNTHACP code is the control rod reactivity model. Control rod reactivity banks are comprised of four power compensation banks G1, G2, N1, N2 and one temperature compensation bank R. The reactivity control configuration of these banks is highly nonlinear, complex and challenging in nature. The control rod reactivity model as a function of G1, G2, N1, N2 and R banks is optimized using two distinct techniques. The control rod reactivity model is optimized using Simplex Linear Programming (SLP) technique under constraints of reactor power as safety limit and control rod speed as maximum speed limit in LabVIEW. The control rod reactivity model is also optimized and investigated using nonlinear Sequential Quadratic Programming (SQP) technique under same constraints in LabVIEW. All the models are integrated and the state-of-the-art virtual instruments (VIs) are designed for cost function optimization, configuring models and calibration of model parameters in LabVIEW. The integrated model as graphical coupled neutronics and thermal hydraulics modeling code is optimized and validated against the Final Safety Analysis Report (FSAR) and different parameters of interest are investigated and proved within design limits as reported with CORCA and CORTH benchmark nuclear codes. The proposed code is stable, highly efficient and accurate as compared to other nuclear codes.
GNTHACP代码是在LabVIEW中设计和开发的用于1100兆瓦先进中国压水堆(ACP-1000)核电站的中子热工学图形工具包。采用非线性点堆动力学模型建立了反应堆中子动力学模型,采用非线性燃料和冷却剂温度动力学建立了反应堆热工力学模型。GNTHACP代码的核心是控制棒反应性模型。控制棒反应性组由4个功率补偿组G1、G2、N1、N2和1个温度补偿组r组成,这些组的反应性控制配置具有高度非线性、复杂性和挑战性。控制棒反应性模型作为G1、G2、N1、N2和R银行的函数,使用两种不同的技术进行优化。在LabVIEW中,以反应堆功率为安全极限,控制棒速度为最大极限,利用单纯形线性规划(SLP)技术对控制棒反应性模型进行优化。在LabVIEW中,利用非线性序列二次规划(SQP)技术对控制棒反应性模型进行了优化和研究。所有模型都集成在LabVIEW中,并设计了最先进的虚拟仪器(VIs),用于成本函数优化,模型配置和模型参数校准。集成模型作为图形耦合的中子和热工力学建模代码进行了优化,并根据最终安全分析报告(FSAR)进行了验证,并根据CORCA和CORTH基准核规范报告的设计限制对不同的感兴趣参数进行了调查和验证。与其他核代码相比,该代码稳定、高效、准确。
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引用次数: 0
Quantum Computer Architecture: A Quantum Circuit-Based Approach Towards Quantum Neural Network 量子计算机体系结构:基于量子电路的量子神经网络方法
Q4 Physics and Astronomy Pub Date : 2023-06-26 DOI: 10.53560/ppasa(60-2)668
Tariq Mahmood, Talab Hussain, Maqsood Ahmed
According to recent research on the brain and cognition, the microtubule level activities in the brain are in accordance with the quantum mechanical concepts. Consciousness is the emergent phenomenon of the brain’s subsystems and the quantum neural correlates. Based on the global work-space theory and traditional neural networks, investigations in machine consciousness and machine intelligence are reporting new techniques.  In this study, a novel approach using circuit-based quantum neural network is proposed and simulated. This approach satisfies all the criteria of quantum computing and is tested for the exclusive OR (XOR) gate’s nonlinear learning. As a result of the use of quantum gates, various quantum circuits, such as quantum adders and subtractors, are also created and included in the designing and simulation of circuit of the quantum neural networks. Moreover, it is also argued that the proposed circuit of quantum neural network may also be tested and implemented on real quantum computer hardware. The present study also stresses the applicability of techniques of machine learning algorithms such as quantum and classical neural networks to various challenges of High Energy Physics.
根据最近对大脑和认知的研究,大脑中微管水平的活动符合量子力学的概念。意识是大脑子系统和量子神经相关体的涌现现象。在全局工作空间理论和传统神经网络的基础上,机器意识和机器智能的研究提出了新的技术。本研究提出并模拟了一种基于电路的量子神经网络方法。该方法满足量子计算的所有标准,并对异或门的非线性学习进行了测试。由于量子门的使用,各种量子电路,如量子加法器和量子减法器也被创造出来,并包括在量子神经网络电路的设计和仿真中。此外,本文还认为所提出的量子神经网络电路也可以在真实的量子计算机硬件上进行测试和实现。本研究还强调了机器学习算法技术(如量子和经典神经网络)在高能物理各种挑战中的适用性。
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引用次数: 0
A Stable Version of the Modified Algorithm for Error Minimization in Combined Numerical Integration 组合数值积分误差最小化改进算法的稳定版本
Q4 Physics and Astronomy Pub Date : 2023-06-01 DOI: 10.53560/ppasa(60-2)813
Aijaz Bhatti, Owais Ali Rajput, Zubair Ahmed Kalhoro
The present study derives a stable version of “A Modified Algorithm for Reduction of Error in Combined Numerical Integration”. It is discovered that the earlier proposed scheme "A Modified Algorithm for Error Reduction in Combined Numerical Integration" exhibits accuracy fluctuations when the number of slits, , is increased .  Starting with the number of slits  and increasing the count of sub-intervals, the error increases spontaneously. This spontaneous spike in error is resolved by considering a better combination of quadrature rules. To this, the notable result of this study is the identification of an optimal choice for quadrature formulae that could minimizes error fluctuations in combined numerical integration regardless the number of slits ( ). With this revised choice, the error remains relatively stable and predictable even as the count of sub-intervals is increased.
本文导出了“组合数值积分中减小误差的改进算法”的一个稳定版本。研究发现,先前提出的“一种改进的组合数值积分误差减小算法”在狭缝数增加时,精度出现波动。从狭缝的数目开始,增加子间隔的数目,误差自然增加。这种自发的误差峰值可以通过考虑更好的正交规则组合来解决。对于这一点,本研究的显著结果是确定了一个最优选择的正交公式,无论狭缝的数量(),都可以使组合数值积分的误差波动最小化。通过修改后的选择,即使子区间的数量增加,误差仍然相对稳定和可预测。
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引用次数: 0
Catalogues of Some Useful Classes of Circular Designs in Blocks of Three Different Sizes to Control Neighbor Effects 控制相邻效应的三种不同大小块中一些有用的圆形设计类别的目录
Q4 Physics and Astronomy Pub Date : 2023-06-01 DOI: 10.53560/ppasa(60-2)812
Akbar Fardos, Abdul Salam, Jamshaid Ul Hassan, Hurria Ali, Khadija Noreen, Rashid Ahmed
Minimal neighbor designs minimize the bias raised due to the neighbor effects using the minimum number of experimental units. Minimal circular balanced and strongly balanced neighbour designs can be constructed only for odd v (number of treatments to be compared). For v even, minimal Quasi Rees and nearly strongly balanced neighbor designs are constructed. In this article, the construction procedures of these four classes are described. Catalogues of these designs in blocks of three different sizes are also presented which provide the readymade solution to the experimenters and researchers.
最小邻居设计使用最小数量的实验单元来最小化由于邻居效应而引起的偏差。最小循环平衡和强平衡邻居设计只能针对奇数v(要比较的处理次数)进行构建。对于v偶,构造了极小拟Rees和近似强平衡邻居设计。本文介绍了这四个类的构造过程。这些设计的目录分为三个不同大小的块,为实验者和研究人员提供现成的解决方案。
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引用次数: 0
Analysis of a City's Heat Island Effect on the Micro-Climate Parameters within Cities 城市热岛效应对城市内部微观气候参数的影响分析
Q4 Physics and Astronomy Pub Date : 2023-06-01 DOI: 10.53560/ppasa(60-2)827
Rishabh Sharma, Khan Amadur Rahman, Vasyl Tyshchenko, Oksana Illiash, Iryna Mezentseva
The Urban Heat Island (UHI) is a micro-climatic phenomenon that influences the urban areas by elevating its temperature. UHI not only causes the thermal discomfort but also exert serious health issues along with aggravation of urban microclimate. Although a lot of research has been done on this phenomenon but UHI effect on micro scale is still less explored. This paper attempts to make a contribution in UHI studies of micro-climate.  It consists of examination of UHI impact on microclimate of Aligarh city areas using mobile traverse method. This study determined the presence and extent of UHI’s microclimate variation within urban communities of different environmental layout and functional uses. The UHI effect started to appear from early afternoon and continue to rise with maximum UHI intensity recorded at early night. The highest recorded UHI intensity was 3.1 °C (at 21:00 hrs.), and the lowest was 0.6 °C (at 09:00 hrs.). A comparison of two districts of the same city located at a distance of 3 km and differing in population density, the number of buildings and landscaping showed that in the L1 area with more dense population and low landscaping, the temperature was consistently higher during the daily period; also in the L1 region had less humidity, which, combined with the already high temperature, makes it difficult to breathe and control the microclimate. These findings can be used for consideration for the future sustainable development of the affected area in regard of thermal comfort, environmental health and urban planning.
城市热岛(UHI)是一种通过提高城市温度来影响城市的微观气候现象。随着城市小气候的加剧,超高温不仅会引起热不适,还会带来严重的健康问题。尽管人们对这一现象进行了大量的研究,但对微观尺度上的UHI效应的探索仍然较少。本文试图为微气候的UHI研究做出贡献。它包括使用移动导线法检查UHI对Aligarh城市地区小气候的影响。本研究确定了不同环境布局和功能用途的城市社区中UHI小气候变化的存在和程度。UHI效应从下午早些时候开始出现,并继续上升,夜间记录到最大UHI强度。有记录的最高UHI强度为3.1°C(21:00),最低为0.6°C(09:00)。对同一城市中位于3公里外且人口密度不同的两个区的建筑数量和景观进行比较后发现,在人口密度更高、景观较差的L1区,在日常生活中,温度始终较高;L1地区的湿度也较小,再加上已经很高的温度,使得呼吸和控制小气候变得困难。这些发现可用于考虑受影响地区在热舒适、环境健康和城市规划方面的未来可持续发展。
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引用次数: 0
Flow Control in a Rectangular Open Channel using Two Impermeable Spur Dikes: A Numerical Study 采用两个不透水丁坝的矩形明渠流量控制的数值研究
Q4 Physics and Astronomy Pub Date : 2023-06-01 DOI: 10.53560/ppasa(60-2)808
Hafiz Syed Moazzum Gillani, Zain-ul-Hassan, Hafiz Rana Azeem Sarwar, Muhammad Sohail Jameel, Waqar Hasan, Ehsaan Manzoor, Imran Khan
The present study examines how adjusting vegetation patches in a rectangular open channel with two impermeable spur dikes alters the displacement of the recirculation region. The Reynolds stress turbulence model is implemented via the 3D numerical code FLUENT (ANSYS). Mean stream-wise velocity profiles were drawn at selected positions and at mid of flow depth i.e., 3.5 cm, a horizontal plane is cut through the open channel for analyzing velocity contours and streamline flow. The findings indicate that the stream-wise velocity profiles showed fluctuations in the presence of different shapes and arrangement of cylindrical patch discussed and the maximum velocity within the field of spur dike is of the order of 0.018 m/s due to the prism shape. By changing the position of the cylindrical patch, the location of the recirculation region displaces within the field of impermeable spur dike.
本研究考察了在具有两个不透水丁坝的矩形明渠中调整植被斑块如何改变回流区的位移。雷诺应力湍流模型是通过三维数值程序FLUENT(ANSYS)实现的。在选定的位置和流深中间(即3.5 cm)绘制平均流向速度剖面,通过明渠切割一个水平面,用于分析速度等值线和流线流。研究结果表明,在所讨论的不同形状和布置的圆柱形斑块的存在下,顺流速度剖面显示出波动,并且由于棱柱形状,丁坝场内的最大速度约为0.018m/s。通过改变圆柱形补片的位置,回流区的位置在不透水丁坝的范围内发生位移。
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引用次数: 0
Stability of Graphene on the Si (111) Surface: Insights from Reactive Molecular Dynamics Simulations 石墨烯在Si(111)表面的稳定性:反应分子动力学模拟的启示
Q4 Physics and Astronomy Pub Date : 2023-06-01 DOI: 10.53560/ppasa(60-2)823
Didik Riyanto, Edy Kurniawan, Husein Muhammad Fras1, Hanifha Nur Azizah, Rizal Arifin
The remarkable characteristics of graphene render it well-suited for a diverse range of applications, particularly in the realm of electronic devices. After the synthesis process, the two-dimensional material known as graphene is then transferred onto a substrate. Silicon (Si) is considered a suitable choice for this purpose. Therefore, it has become essential to investigate the stability of graphene on silicon surfaces. This study utilized reactive molecular dynamics simulations to investigate the thermal stability of graphene on a Si (111) substrate across a temperature range of 300 to 1500 K. The results demonstrate the exceptional stability of graphene on this particular surface. This phenomenon can be explained by the restricted intermolecular interactions between the carbon atoms in graphene and the silicon atoms on the substrate surface. The study findings indicate that graphene exhibits a dome-shaped configuration on the Si (111) surface. In this configuration, only the carbon atoms located at the periphery of the graphene structure interact with the silicon atoms present on the underlying substrate.
石墨烯的显著特性使其非常适合各种应用,特别是在电子设备领域。在合成过程之后,被称为石墨烯的二维材料被转移到基底上。硅(Si)被认为是用于此目的的合适选择。因此,研究石墨烯在硅表面的稳定性变得至关重要。这项研究利用反应分子动力学模拟研究了石墨烯在硅(111)衬底上在300至1500 K温度范围内的热稳定性。结果表明,石墨烯在该特定表面上具有非凡的稳定性。这种现象可以通过石墨烯中的碳原子和衬底表面的硅原子之间的分子间相互作用来解释。研究结果表明,石墨烯在Si(111)表面呈现出圆顶状结构。在这种配置中,只有位于石墨烯结构外围的碳原子与下层衬底上的硅原子相互作用。
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引用次数: 0
期刊
Proceedings of the Pakistan Academy of Sciences: Part A
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