Seyedeh Shadi Mousavi, K. Molanorouzi, M. Shojaei, Seyed Mohyeddin Bahari
Background and Objective During the COVID-19 pandemic, there were increased reports of sleep problems. Individuals with poor sleep quality are at particular risk of reporting symptoms of anxiety, depression, and poor quality of life, along with substance abuse. The present study aimed to examine the effectiveness of combined physical activity and acceptance and commitment therapy (ACT) on anxiety and depressive symptoms and insomnia severity among individuals with poor sleep quality.Methods Participants were 60 males and females with mean age (standard deviation) of 39.29 (5.82) years. Participants were randomly divided into 4 groups of 1) physical activity, 2) ACT, 3) combination of physical activity and ACT, and 4) control. The study consisted of four stages: pre-test, interventions, post-test, and follow-up. Repeated measures analyses of variance were used to assess time by group interactions.Results The results showed that the symptoms of anxiety and depression and sleep problems were reduced for the physical activity, ACT, and combined groups, compared to the control group (p = 0.001). Superiority in all outcomes of the combined group was shown, compared to the other groups.Conclusions The present findings suggest that among individuals with poor sleep quality, combined physical activity and ACT intervention has the potential to reduce symptoms of anxiety and depression and insomnia severity. It further appears that health organizers should pay more attention to physical activity interventions in individuals with poor sleep quality.
{"title":"Physical Activity Plus Acceptance and Commitment Therapy Can Decrease Anxiety Symptoms and Insomnia Severity Among Individuals With Poor Sleep Quality","authors":"Seyedeh Shadi Mousavi, K. Molanorouzi, M. Shojaei, Seyed Mohyeddin Bahari","doi":"10.17241/smr.2022.01543","DOIUrl":"https://doi.org/10.17241/smr.2022.01543","url":null,"abstract":"Background and Objective During the COVID-19 pandemic, there were increased reports of sleep problems. Individuals with poor sleep quality are at particular risk of reporting symptoms of anxiety, depression, and poor quality of life, along with substance abuse. The present study aimed to examine the effectiveness of combined physical activity and acceptance and commitment therapy (ACT) on anxiety and depressive symptoms and insomnia severity among individuals with poor sleep quality.Methods Participants were 60 males and females with mean age (standard deviation) of 39.29 (5.82) years. Participants were randomly divided into 4 groups of 1) physical activity, 2) ACT, 3) combination of physical activity and ACT, and 4) control. The study consisted of four stages: pre-test, interventions, post-test, and follow-up. Repeated measures analyses of variance were used to assess time by group interactions.Results The results showed that the symptoms of anxiety and depression and sleep problems were reduced for the physical activity, ACT, and combined groups, compared to the control group (p = 0.001). Superiority in all outcomes of the combined group was shown, compared to the other groups.Conclusions The present findings suggest that among individuals with poor sleep quality, combined physical activity and ACT intervention has the potential to reduce symptoms of anxiety and depression and insomnia severity. It further appears that health organizers should pay more attention to physical activity interventions in individuals with poor sleep quality.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45481666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective Intermittent fasting has become a popular topic in recent years, with many people turning to this dietary approach to improve their health and manage their weight. It has also been studied for its potential impact on various aspects of health, including sleep and physical performance. This study aimed to investigate the impacts of intermittent fasting during Ramadan and chronotype on sleep quality and aerobic performance in young athletes.Methods This study is a prospective cohort design with repeated measurements, including 117 amateur athletes (16.86 ± 1.07 years) from Morocco. The aerobic performance was measured with the 20-m shuttle-run test. We also assessed sleep quality with the Pittsburgh Sleep Quality Index. The chronotype was assessed by the Morningness-Eveningness Questionnaire. We examined the difference in means before and during Ramadan; then, we analyzed the correlation between all variables.Results The current study showed that while aerobic performance and sleep quality declined during Ramadan, those with good sleep quality performed better in all periods. It also showed that chronotype is correlated with the aerobic performance before but not during Ramadan. However, the chronotype is associated with the sleep quality before and during Ramadan.Conclusions During Ramadan, athletes must build coping strategies to improve their sleep quality and maintain optimal physical performance.
{"title":"Chronotype, Aerobic Performance, and Sleep Quality of Young Athletes Before and During Ramadan Observance","authors":"A. El-Jaziz, S. Lotfi","doi":"10.17241/smr.2023.01739","DOIUrl":"https://doi.org/10.17241/smr.2023.01739","url":null,"abstract":"Background and Objective Intermittent fasting has become a popular topic in recent years, with many people turning to this dietary approach to improve their health and manage their weight. It has also been studied for its potential impact on various aspects of health, including sleep and physical performance. This study aimed to investigate the impacts of intermittent fasting during Ramadan and chronotype on sleep quality and aerobic performance in young athletes.Methods This study is a prospective cohort design with repeated measurements, including 117 amateur athletes (16.86 ± 1.07 years) from Morocco. The aerobic performance was measured with the 20-m shuttle-run test. We also assessed sleep quality with the Pittsburgh Sleep Quality Index. The chronotype was assessed by the Morningness-Eveningness Questionnaire. We examined the difference in means before and during Ramadan; then, we analyzed the correlation between all variables.Results The current study showed that while aerobic performance and sleep quality declined during Ramadan, those with good sleep quality performed better in all periods. It also showed that chronotype is correlated with the aerobic performance before but not during Ramadan. However, the chronotype is associated with the sleep quality before and during Ramadan.Conclusions During Ramadan, athletes must build coping strategies to improve their sleep quality and maintain optimal physical performance.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47160262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective Obstructive sleep apnea (OSA) is a breathing disorder during sleep with an obstruction of the upper airway. Previous studies showed OSA as a risk factor for severe COVID-19. It is crucial to determine the risk factors for the severity of COVID-19 infection. We aim to clarify the relationship between COVID-19 severity, and OSA and its degree.Methods Our case-control study included subjects diagnosed with OSA with polysomnography between January 2018 and November 2021, and a control group with a history of COVID-19 infection and without OSA diagnosis. The demographic data, comorbidities, apnea–hypopnea index, and oxygen desaturation index were recorded.Results A total of 217 patients were included in our study. The degree of OSA was a risk factor in the OSA group (p < 0.05); on the other hand, the diagnosis of OSA by itself was not a risk factor. The apnea–hypopnea index and oxygen desaturation index were not related to the severity of COVID-19 infection (p > 0.05). Diabetes mellitus was associated with increased hospitalization in inpatient clinics (p < 0.05) and intensive care unit (ICU) (p < 0.05). Chronic obstructive pulmonary disease was a risk factor for admission to the ICU (p < 0.05).Conclusions Our results showed that moderate-to-severe OSA patients are a vulnerable population to severe COVID-19 infection, although diagnosis of OSA by itself was not a risk factor.
{"title":"Is Obstructive Sleep Apnea a Risk Factor for Severe COVID-19?","authors":"N. Zerman, C. Aydın","doi":"10.17241/smr.2022.01592","DOIUrl":"https://doi.org/10.17241/smr.2022.01592","url":null,"abstract":"Background and Objective Obstructive sleep apnea (OSA) is a breathing disorder during sleep with an obstruction of the upper airway. Previous studies showed OSA as a risk factor for severe COVID-19. It is crucial to determine the risk factors for the severity of COVID-19 infection. We aim to clarify the relationship between COVID-19 severity, and OSA and its degree.Methods Our case-control study included subjects diagnosed with OSA with polysomnography between January 2018 and November 2021, and a control group with a history of COVID-19 infection and without OSA diagnosis. The demographic data, comorbidities, apnea–hypopnea index, and oxygen desaturation index were recorded.Results A total of 217 patients were included in our study. The degree of OSA was a risk factor in the OSA group (p < 0.05); on the other hand, the diagnosis of OSA by itself was not a risk factor. The apnea–hypopnea index and oxygen desaturation index were not related to the severity of COVID-19 infection (p > 0.05). Diabetes mellitus was associated with increased hospitalization in inpatient clinics (p < 0.05) and intensive care unit (ICU) (p < 0.05). Chronic obstructive pulmonary disease was a risk factor for admission to the ICU (p < 0.05).Conclusions Our results showed that moderate-to-severe OSA patients are a vulnerable population to severe COVID-19 infection, although diagnosis of OSA by itself was not a risk factor.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44178742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zakya Ageed Tufeq, Aziza Mohammed Ziyab, Bushra Abdulla Ahmed, Mohmmed Khuder Nafea Rahho, D. Abdulah
Background and Objective The role of insomnia in the well-being of school children has not been sufficiently examined in the literature. We aimed to explore the prevalence of clinical insomnia and its relationship to the health-related quality of life among female high-school students.Methods In a cross-sectional study in 2018, 300 students from five female high-schools in the Kurdistan Region were randomly included, regardless of age and other socio-demographic characteristics. The Personal Wellbeing Index, General Health Questionnaire–12, and Insomnia Severity Index were used to measure the personal and general well-being, and insomnia of school children, respectively.Results The students were categorized into short sleepers (2.0%), normal sleepers (51.0%), and long sleepers (47.0%), and age range is 14–19 years (mean: 16.22 years). The mean value of general well-being and insomnia severity was 6.89 and 11.42, respectively. We found that 25.0% of the students had no clinically significant insomnia, 47.7% had subthreshold insomnia, 24.0% had clinically moderate insomnia, and 3.3% had clinically severe insomnia. The mean value of the personal well-being of students was 7.91 out of 10. The mean value of personal well-being was significantly lower among students with more severe insomnia. The mean values of personal well-being were 8.61 (no clinically significant insomnia), 7.87 (subthreshold insomnia), 7.49 (clinically moderate insomnia), and 6.91 (clinically severe insomnia). The worse sleep situations and smoking were the main independent controlling factors for lower personal well-being.Conclusions The study documented that female students are at risk of being clinical insomniacs, and are at risk of the development of lower well-being.
{"title":"Sleep Patterns, Insomnia, and Well-Being Among Female High School Students: A Population-Based Study","authors":"Zakya Ageed Tufeq, Aziza Mohammed Ziyab, Bushra Abdulla Ahmed, Mohmmed Khuder Nafea Rahho, D. Abdulah","doi":"10.17241/smr.2023.01683","DOIUrl":"https://doi.org/10.17241/smr.2023.01683","url":null,"abstract":"Background and Objective The role of insomnia in the well-being of school children has not been sufficiently examined in the literature. We aimed to explore the prevalence of clinical insomnia and its relationship to the health-related quality of life among female high-school students.Methods In a cross-sectional study in 2018, 300 students from five female high-schools in the Kurdistan Region were randomly included, regardless of age and other socio-demographic characteristics. The Personal Wellbeing Index, General Health Questionnaire–12, and Insomnia Severity Index were used to measure the personal and general well-being, and insomnia of school children, respectively.Results The students were categorized into short sleepers (2.0%), normal sleepers (51.0%), and long sleepers (47.0%), and age range is 14–19 years (mean: 16.22 years). The mean value of general well-being and insomnia severity was 6.89 and 11.42, respectively. We found that 25.0% of the students had no clinically significant insomnia, 47.7% had subthreshold insomnia, 24.0% had clinically moderate insomnia, and 3.3% had clinically severe insomnia. The mean value of the personal well-being of students was 7.91 out of 10. The mean value of personal well-being was significantly lower among students with more severe insomnia. The mean values of personal well-being were 8.61 (no clinically significant insomnia), 7.87 (subthreshold insomnia), 7.49 (clinically moderate insomnia), and 6.91 (clinically severe insomnia). The worse sleep situations and smoking were the main independent controlling factors for lower personal well-being.Conclusions The study documented that female students are at risk of being clinical insomniacs, and are at risk of the development of lower well-being.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46198676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Purwanto, Mahadir Ahmad, Zaini Said, N. Anganthi, Y. Kusumawati, Siti Zulaekah
Background and Objective Lockdown, social confinement, and the uncertainty of the COVID-19 pandemic have increased mental health disorders and affected sleep disorders, especially insomnia. This study aims to explain the prevalence of insomnia before and during the COVID-19 pandemic in Surakarta, Indonesia.Methods This cross-sectional survey was conducted twice in Surakarta city. The survey was conducted before the pandemic with 456 participants and during the pandemic with 1254 participants. All participants were selected using the purposive sampling method with criteria of age 15–44 years and having sleep problems. The online questionnaire of the Insomnia Severity Index Indonesian version (ISI–INA) was used to collect insomnia data. The statistical analysis was conducted using SPSS v25 by a descriptive test and Mann–Whitney test.Results The mean total ISI–INA scores before and during the pandemic were 13.83 and 12.54. Surveys found that the participants who suffered from subthreshold insomnia, moderate, and severe insomnia before the pandemic were 45.6%, 41.2%, and 5%, respectively, while during the pandemic 42.1%, 35%, and 3.5%, respectively. There was a difference between before and during the pandemic in the mean total ISI scores, severity of insomnia, difficulty in falling asleep and maintaining sleep, waking up too early, sleep dissatisfaction, noticeability of sleep problems by others, and interference of sleep problems with daytime activities (p < 0.05), while there was no difference in the worried about sleep problems (p > 0.05).Conclusions The prevalence of insomnia during the COVID-19 pandemic is lower than before the COVID-19 pandemic. Overall, the prevalence of insomnia remains relatively high, so gradual and continuous intervention is needed to overcome insomnia.
{"title":"Prevalence of Insomnia at Before and During the COVID-19 Pandemic","authors":"S. Purwanto, Mahadir Ahmad, Zaini Said, N. Anganthi, Y. Kusumawati, Siti Zulaekah","doi":"10.17241/smr.2023.01613","DOIUrl":"https://doi.org/10.17241/smr.2023.01613","url":null,"abstract":"Background and Objective Lockdown, social confinement, and the uncertainty of the COVID-19 pandemic have increased mental health disorders and affected sleep disorders, especially insomnia. This study aims to explain the prevalence of insomnia before and during the COVID-19 pandemic in Surakarta, Indonesia.Methods This cross-sectional survey was conducted twice in Surakarta city. The survey was conducted before the pandemic with 456 participants and during the pandemic with 1254 participants. All participants were selected using the purposive sampling method with criteria of age 15–44 years and having sleep problems. The online questionnaire of the Insomnia Severity Index Indonesian version (ISI–INA) was used to collect insomnia data. The statistical analysis was conducted using SPSS v25 by a descriptive test and Mann–Whitney test.Results The mean total ISI–INA scores before and during the pandemic were 13.83 and 12.54. Surveys found that the participants who suffered from subthreshold insomnia, moderate, and severe insomnia before the pandemic were 45.6%, 41.2%, and 5%, respectively, while during the pandemic 42.1%, 35%, and 3.5%, respectively. There was a difference between before and during the pandemic in the mean total ISI scores, severity of insomnia, difficulty in falling asleep and maintaining sleep, waking up too early, sleep dissatisfaction, noticeability of sleep problems by others, and interference of sleep problems with daytime activities (p < 0.05), while there was no difference in the worried about sleep problems (p > 0.05).Conclusions The prevalence of insomnia during the COVID-19 pandemic is lower than before the COVID-19 pandemic. Overall, the prevalence of insomnia remains relatively high, so gradual and continuous intervention is needed to overcome insomnia.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42296867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective This study undertook a systematic review and meta-analysis of the relationship between sleep duration, sleep quality, and insomnia in association with self-rated health.Methods Studies that had examined the relationship between sleep duration, sleep quality, and insomnia with self-rated health were eligible. PubMed and Scopus were the two main databases for searching for studies related to this meta-analysis. The Google Scholar database as a source of gray literature was also searched by hand. This search was from the beginning of the formation of databases until the end of January 2022, and the search language was limited to articles published in English. The Effective Public Health Practice Project Quality Assessment Tool was used to assess the quality of studies. For this meta-analysis, odds ratio and 95% confidence interval were extracted or calculated. The pool of studies was processed by the random effects method.Results Twenty-six studies were included in this meta-analysis. Sleep duration of ≤ 8 hours per day (h/d) (odds ratio = 1.58 and 95% confidence interval = [1.41–1.77]) and sleep duration of > 8 h/d (odds ratio = 1.32 and 95% confidence interval = [1.17–1.50]) are associated with poor self-rated health. Poor sleep quality and insomnia are associated with poor self-rated health. Conclusions Sleep problems have a negative effect on self-rated health, and therefore, effective interventions can help improve sleep.
{"title":"Sleep Duration, Sleep Quality, and Insomnia in Association With Self-Rated Health: A Systematic Review and Meta-Analysis","authors":"S. Amiri","doi":"10.17241/smr.2023.01732","DOIUrl":"https://doi.org/10.17241/smr.2023.01732","url":null,"abstract":"Background and Objective This study undertook a systematic review and meta-analysis of the relationship between sleep duration, sleep quality, and insomnia in association with self-rated health.Methods Studies that had examined the relationship between sleep duration, sleep quality, and insomnia with self-rated health were eligible. PubMed and Scopus were the two main databases for searching for studies related to this meta-analysis. The Google Scholar database as a source of gray literature was also searched by hand. This search was from the beginning of the formation of databases until the end of January 2022, and the search language was limited to articles published in English. The Effective Public Health Practice Project Quality Assessment Tool was used to assess the quality of studies. For this meta-analysis, odds ratio and 95% confidence interval were extracted or calculated. The pool of studies was processed by the random effects method.Results Twenty-six studies were included in this meta-analysis. Sleep duration of ≤ 8 hours per day (h/d) (odds ratio = 1.58 and 95% confidence interval = [1.41–1.77]) and sleep duration of > 8 h/d (odds ratio = 1.32 and 95% confidence interval = [1.17–1.50]) are associated with poor self-rated health. Poor sleep quality and insomnia are associated with poor self-rated health. Conclusions Sleep problems have a negative effect on self-rated health, and therefore, effective interventions can help improve sleep.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47181366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catathrenia is a rare type of sleep-related breathing disorder with benign course and generally does not require treatment. However, the psychological burden on patients and bed partners is not light. In most cases, due to the sound characteristic of identifiable harmonics, it can be easily diagnosed; however, in some cases, it has non-typical sounds, and polysomnography is essential to diagnose. Here, I report a middle-aged woman with choking sounds like an obstructive sleep apnea patient during sleep, with typical polysomnography features of catathrenia.
{"title":"Atypical Catathrenia Mimicking Sleep Choking Sound of Obstructive Sleep Apnea","authors":"K. Ji","doi":"10.17241/smr.2023.01634","DOIUrl":"https://doi.org/10.17241/smr.2023.01634","url":null,"abstract":"Catathrenia is a rare type of sleep-related breathing disorder with benign course and generally does not require treatment. However, the psychological burden on patients and bed partners is not light. In most cases, due to the sound characteristic of identifiable harmonics, it can be easily diagnosed; however, in some cases, it has non-typical sounds, and polysomnography is essential to diagnose. Here, I report a middle-aged woman with choking sounds like an obstructive sleep apnea patient during sleep, with typical polysomnography features of catathrenia.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47419573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sang-Wook Kim, S. Sands, D. Vena, L. Hess, N. Calianese, Robert James Konefal, L. Taranto-Montemurro, A. Azarbarzin, C. Czeisler, T. Laidlaw, A. Wellman
Patients with chronic rhinosinusitis (CRS) report improved sleep quality after dupilumab, an anti IL4/13 therapy. Concurrent CRS and obstructive sleep apnea (OSA) cases are not rare, and CRS seemingly raises nasal resistance. Thus, we hypothesized that improved sleep quality by dupilumab therapy in CRS patients might be due to lowered nasal resistance and subsequent improvement of unrecognized comorbid OSA. Patients with concurrent CRS and OSA were recruited. Nasal resistance was measured invasively with transnasal pressure and flow data collected during normal respiration in the supine position. Results from the first five participants did not support our hypothesis. Subjective and objective measures for CRS and nasal resistance values were improved with dupilumab therapy in CRS patients with nasal polyps. However, apnea severity and sleep-related subjective parameters did not change. In the patients with CRS without nasal polyps, no significant changes in either CRS or OSA-related measures were observed.
{"title":"Effect of Dupilumab on Sleep Apnea Severity in Patients With Chronic Rhinosinusitis","authors":"Sang-Wook Kim, S. Sands, D. Vena, L. Hess, N. Calianese, Robert James Konefal, L. Taranto-Montemurro, A. Azarbarzin, C. Czeisler, T. Laidlaw, A. Wellman","doi":"10.17241/smr.2023.01641","DOIUrl":"https://doi.org/10.17241/smr.2023.01641","url":null,"abstract":"Patients with chronic rhinosinusitis (CRS) report improved sleep quality after dupilumab, an anti IL4/13 therapy. Concurrent CRS and obstructive sleep apnea (OSA) cases are not rare, and CRS seemingly raises nasal resistance. Thus, we hypothesized that improved sleep quality by dupilumab therapy in CRS patients might be due to lowered nasal resistance and subsequent improvement of unrecognized comorbid OSA. Patients with concurrent CRS and OSA were recruited. Nasal resistance was measured invasively with transnasal pressure and flow data collected during normal respiration in the supine position. Results from the first five participants did not support our hypothesis. Subjective and objective measures for CRS and nasal resistance values were improved with dupilumab therapy in CRS patients with nasal polyps. However, apnea severity and sleep-related subjective parameters did not change. In the patients with CRS without nasal polyps, no significant changes in either CRS or OSA-related measures were observed.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43855630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep and epilepsy have a complex interrelationship that is influenced by various factors, including the distinct stages of sleep. Non-rapid eye movement sleep promotes epileptic activity, while rapid eye movement sleep suppresses it. Seizures can be triggered by sleep, while sleep deprivation increases seizure susceptibility. Epilepsy disrupts sleep architecture and quality, leading to sleep disturbances and comorbidities, like sleep apnea and restless legs syndrome. Excessive daytime sleepiness and fatigue can result from epilepsy and the sedating effects of antiseizure medications. Sleep-related epilepsy exhibits seizures predominantly during sleep, with specific patterns related to sleep stages. Antiseizure medications can directly impact sleep quality and should be carefully considered when treating epilepsy patients with comorbid sleep disorders. Understanding the bidirectional relationship between sleep and epilepsy is crucial for effective management. Optimizing treatment strategies requires recognizing the effects of antiseizure medications on sleep, and addressing sleep-related issues in individuals with epilepsy.
{"title":"Sleep and Epilepsy","authors":"Kyung Min Kim, Kwang Ik Yang","doi":"10.17241/smr.2023.01781","DOIUrl":"https://doi.org/10.17241/smr.2023.01781","url":null,"abstract":"Sleep and epilepsy have a complex interrelationship that is influenced by various factors, including the distinct stages of sleep. Non-rapid eye movement sleep promotes epileptic activity, while rapid eye movement sleep suppresses it. Seizures can be triggered by sleep, while sleep deprivation increases seizure susceptibility. Epilepsy disrupts sleep architecture and quality, leading to sleep disturbances and comorbidities, like sleep apnea and restless legs syndrome. Excessive daytime sleepiness and fatigue can result from epilepsy and the sedating effects of antiseizure medications. Sleep-related epilepsy exhibits seizures predominantly during sleep, with specific patterns related to sleep stages. Antiseizure medications can directly impact sleep quality and should be carefully considered when treating epilepsy patients with comorbid sleep disorders. Understanding the bidirectional relationship between sleep and epilepsy is crucial for effective management. Optimizing treatment strategies requires recognizing the effects of antiseizure medications on sleep, and addressing sleep-related issues in individuals with epilepsy.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The ongoing coronavirus disease 2019 (COVID-19) pandemic is the third global crisis after two epidemics of severe acute respiratory syndromes. It has affected general public besides health care systems and governments. Confinements and lock downs have changed waking up time and going to bed time, ultimately affecting circadian clocks that can disturb sleep quality which can lead to anxiety, stress, and depression. This puts the most susceptible group -young adults and females- at risk of psychological disorders and even inflammatory events. Several kinds of sleep disorders due to COVID-19 including insomnia, sleep apnea, sleepiness during daytime, post-traumatic-like sleep dysfunction, abnormal dreams, and restless legs syndrome have been reported. As sleep deprivation can alter circadian clock and weaken immunity which makes human more susceptible to pulmonary inflammatory process of COVID-19 and even enhance its manifestations, it should be considered as an urgent complication that needs to be treated. Furthermore, longstanding effects of sleep disturbances during COVID-19 pandemic need to be elucidated.
{"title":"Impacts of Coronavirus Disease 2019 Pandemic on Sleep Pattern","authors":"Samira Rabiei, M. Nazari","doi":"10.17241/smr.2022.01557","DOIUrl":"https://doi.org/10.17241/smr.2022.01557","url":null,"abstract":"The ongoing coronavirus disease 2019 (COVID-19) pandemic is the third global crisis after two epidemics of severe acute respiratory syndromes. It has affected general public besides health care systems and governments. Confinements and lock downs have changed waking up time and going to bed time, ultimately affecting circadian clocks that can disturb sleep quality which can lead to anxiety, stress, and depression. This puts the most susceptible group -young adults and females- at risk of psychological disorders and even inflammatory events. Several kinds of sleep disorders due to COVID-19 including insomnia, sleep apnea, sleepiness during daytime, post-traumatic-like sleep dysfunction, abnormal dreams, and restless legs syndrome have been reported. As sleep deprivation can alter circadian clock and weaken immunity which makes human more susceptible to pulmonary inflammatory process of COVID-19 and even enhance its manifestations, it should be considered as an urgent complication that needs to be treated. Furthermore, longstanding effects of sleep disturbances during COVID-19 pandemic need to be elucidated.","PeriodicalId":37318,"journal":{"name":"Sleep Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45272295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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