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Effects of Continuous Positive Airway Pressure on White Matter Microstructure in Patients With Obstructive Sleep Apnea 持续气道正压对阻塞性睡眠呼吸暂停患者白质微结构的影响
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2022.01459
Hea Ree Park, Hye Ryun Kim, J. Seong, E. Joo
Background and Objective Obstructive sleep apnea (OSA) has significant effects on quality of life and may lead to cognitive impairments. Continuous positive airway pressure (CPAP) is the standard treatment for OSA and has been shown to improve sleep disturbances and daytime dysfunction. In this study, we aimed to assess the effects of CPAP on white matter (WM) integrity using longitudinal diffusion tensor imaging (DTI) tests.Methods Twenty-two male patients with moderate to severe OSA were recruited, and thepatients underwent DTI scanning before and 6–44 months after CPAP treatment. Sixteen male patients with untreated OSA who were not compliant with CPAP were included as a reference group. We compared the functional anisotropy (FA) values between baseline and follow-up magnetic resonance imaging in both the CPAP and untreated groups using tract-specific statistical analysis (TSSA) method.Results The TSSA analysis showed that FA values in the middle part of the right corticospinal tract were increased after treatment in the CPAP group. In the untreated group, no significant change in FA value was observed between baseline and follow-up. In the CPAP group, the post-treatment FA value in the anterior part of the right anterior thalamic radiation was significantly correlated with the duration of CPAP therapy, after controlling for age, body mass index, and baseline FA value.Conclusions Our study suggests that long-term CPAP treatment could gradually reverse OSA-induced injury to the WM microstructure, particularly WM associated with the motor and limbic systems. The study findings provide new insights into the mechanisms of cognitive improvement after CPAP treatment in patients with OSA.
背景与目的阻塞性睡眠呼吸暂停(OSA)对生活质量有显著影响,并可能导致认知障碍。持续气道正压通气(CPAP)是OSA的标准治疗方法,已被证明可以改善睡眠障碍和日间功能障碍。在本研究中,我们旨在使用纵向扩散张量成像(DTI)测试来评估CPAP对白质(WM)完整性的影响。方法选择22例男性中重度OSA患者,在CPAP治疗前和治疗后6~44个月进行DTI扫描。16名未经治疗且不符合CPAP的OSA男性患者被纳入参考组。我们使用道特异性统计分析(TSSA)方法比较了CPAP组和未治疗组的基线和随访磁共振成像之间的功能各向异性(FA)值。结果经TSSA分析,CPAP组治疗后右侧皮质脊髓束中部FA值升高。在未治疗组中,从基线到随访期间,FA值没有观察到显著变化。在CPAP组中,在控制了年龄、体重指数和基线FA值后,右前丘脑辐射前部的治疗后FA值与CPAP治疗的持续时间显著相关。结论我们的研究表明,长期CPAP治疗可以逐渐逆转OSA诱导的WM微观结构损伤,特别是与运动和边缘系统相关的WM。研究结果为OSA患者CPAP治疗后认知改善的机制提供了新的见解。
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引用次数: 0
Does Viral Anxiety Influence the Insomnia Severity Among Patients With Insomnia Disorder During COVID-19 Pandemic? COVID-19大流行期间病毒性焦虑是否影响失眠患者的失眠严重程度?
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2022.01480
Jana Sleiman, E. Cho, Dongin Lee, Inn-Kyu Cho, Seockhoon Chung, O. Uygur
Background and Objective We aimed to investigate whether viral anxiety affects insomnia severity in patients with insomnia disorder during the coronavirus disease 2019 (COVID-19) pandemic. In addition, we examined whether viral anxiety mediates the influence of dysfunctional beliefs about sleep on insomnia severity.Methods The medical records of 111 patients who visit the sleep clinic from September 2021 to May 2022 were reviewed. Patients’ symptoms were rated with rating scales including Insomnia Severity Index (ISI), Stress and Anxiety to Viral Epidemics-6 items (SAVE-6), Dysfunctional Beliefs and Attitudes about Sleep-16 items (DBAS-16), Patient Health Questionnaire-9 items (PHQ-9), Epworth Sleepiness Scale, and discrepancy between desired time in bed and desired total sleep time (the DBST index).Results The SAVE-6 score was not significantly correlated with ISI score among insomnia patients. Linear regression analysis showed that the ISI score was expected by PHQ-9 (β = 0.21, p = 0.038) and DBAS-16 (β = 0.42, p < 0.001). Mediation analysis showed that viral anxiety did not mediate the influence of dysfunctional beliefs about sleep on insomnia severity.Conclusions We could not observe the mediating effect of viral anxiety on the association between dysfunctional beliefs about sleep on insomnia severity. Though COVID-somnia was one of big issues in this COVID-19 pandemic, the influence of virus on the severity of insomnia among insomnia patients needs to be interpreted cautiously.
背景和目的我们旨在调查2019冠状病毒病(新冠肺炎)大流行期间,病毒性焦虑是否影响失眠障碍患者的失眠严重程度。此外,我们还研究了病毒性焦虑是否介导了关于睡眠的功能失调信念对失眠严重程度的影响。方法对2021年9月至2022年5月在睡眠门诊就诊的111例患者的病历进行回顾性分析。采用失眠严重程度指数(ISI)、对病毒性流行病的压力和焦虑-6项(SAVE-6)、对睡眠的功能障碍信念和态度-16项(DBAS-16)、患者健康问卷-9项(PHQ-9)、Epworth嗜睡量表,结果失眠患者的SAVE-6评分与ISI评分无显著相关性。线性回归分析表明,PHQ-9(β=0.21,p=0.038)和DBAS-16(β=0.42,p<0.001)预期ISI评分。中介分析表明,病毒性焦虑不会介导对睡眠的功能失调信念对失眠严重程度的影响。结论我们没有观察到病毒性焦虑对睡眠功能失调信念与失眠严重程度之间关系的中介作用。尽管新冠肺炎是这场新冠肺炎大流行中的一大问题,但病毒对失眠患者失眠严重程度的影响需要谨慎解读。
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引用次数: 0
Factors Associated With Sleeping Quality and Behaviors Among University Students in Malaysia 马来西亚大学生睡眠质量和行为的相关因素
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2022.01536
S. C. Ong, Nizuwan Azman, Hui Ting Ho
Background and Objective Sleep is an important physiological process for humans. Students of tertiary institutions, especially those at the university, are often reported to have poor sleep quality due to changing social opportunities and increasing academic demands. This study aimed to investigate the prevalence of poor sleeping quality and its relationship with academic performance and psychological distress among university students in Malaysia.Methods An online questionnaire-based, cross-sectional study was conducted among students of tertiary institutions in Malaysia. The questionnaire consisted of respondents’ demographics, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Horne-Ostberg Morningness-Eveningness Scale (MES) and Depression-Anxiety-Stress Scales (DASS-21). Simple and multiple linear regression were used to identify the relationship between the independent and dependent variables (PSQI score and MES score).Results Of the 403 respondents, about three-fourths were poor-quality sleepers. The cumulative grade point average (CGPA) was the only factor with a significant linear and positive relationship with the PSQI score. Only the depression and anxiety scores showed a significant linear and positive relationship between the PSQI score and the MES score.Conclusions Poor sleep quality was prevalent among university students. Poor sleep was associated with better academic performance. Students with depression or anxiety were significantly associated with poor sleep quality and being a morning bird.
背景与目的睡眠是人类重要的生理过程。据报道,由于社会机会的变化和学术需求的增加,高等院校的学生,尤其是大学里的学生,睡眠质量往往很差。本研究旨在调查马来西亚大学生睡眠质量差的患病率及其与学习成绩和心理困扰的关系。该问卷由受访者的人口统计数据、匹兹堡睡眠质量指数(PSQI)、埃普沃斯睡眠量表(ESS)、霍恩-奥斯特伯格晨曦均匀度量表(MES)和抑郁-焦虑-压力量表(DAS-21)组成。结果在403名受访者中,约四分之三的人睡眠质量较差。累积绩点平均值(CGPA)是唯一与PSQI评分呈显著线性正相关的因素。只有抑郁和焦虑评分显示PSQI评分和MES评分之间存在显著的线性和正相关关系。结论大学生普遍存在睡眠质量差的现象。睡眠不足与学习成绩提高有关。患有抑郁症或焦虑症的学生与睡眠质量差和爱早起的人显著相关。
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引用次数: 0
Challenges in Diagnosing Narcolepsy and Idiopathic Hypersomnia 诊断嗜睡症和特发性嗜睡的挑战
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2023.01669
Seung-Chul Hong, J. Song, Tae-Won Kim, Young-Chan Kim
Narcolepsy and idiopathic hypersomnia are central disorders of hypersomnolence accompanied by excessive daytime sleepiness, which are not caused by nocturnal sleep disturbance, sleep deficiency, or circadian rhythm sleep disorders. Several studies have questioned the repeatability of the Multiple Sleep Latency Test (MSLT) in type 2 narcolepsy (NT2) patients. After two or more repeated MSLTs, the diagnosis of type 1 narcolepsy (NT1) is maintained in more than 90% of cases, while only half of the NT2 patients retain their original diagnosis. The diagnosis of NT2 may shift to idiopathic hypersomnia based on the MSLT results, making the differential diagnosis of NT2 and idiopathic hypersomnia particularly challenging. Therefore, this study suggests the need for new tests in addition to the MSLT for diagnostic consistency in NT2 and idiopathic hypersomnia.
嗜睡症和特发性嗜睡是伴随白天过度嗜睡的嗜睡的中心性疾病,不是由夜间睡眠障碍、睡眠不足或昼夜节律睡眠障碍引起的。几项研究对2型发作性睡病(NT2)患者的多次睡眠潜伏期测试(MSLT)的可重复性提出了质疑。在两次或两次以上重复MSLT后,超过90%的病例维持了1型发作性睡病(NT1)的诊断,而只有一半的NT2患者保留了最初的诊断。根据MSLT结果,NT2的诊断可能会转变为特发性嗜睡,这使得NT2和特发性失眠的鉴别诊断特别具有挑战性。因此,这项研究表明,除了MSLT之外,还需要新的测试来保持NT2和特发性嗜睡的诊断一致性。
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引用次数: 0
Patient Health Questionnaire-9, Body Mass Index, Household Income According to Sleep Duration: Findings From a Community Health Survey 病人健康问卷-9、身体质量指数、与睡眠时间相关的家庭收入:一项社区健康调查的结果
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2023.01662
Jihyung Lee, Y. Um, Jong-Hyun Jeong, H. Seo, Young-Chan Kim, Sung Hoon Yoon, S. Kim, Tae-Won Kim, Seung-Chul Hong
Background and Objective Research on the relationship between sleep duration and Patient Health Questionnaire-9 (PHQ-9), body mass index (BMI), and income in South Korea was scarce. This study aimed to investigate the relationship between sleep duration and the PHQ-9, BMI, and household income.Methods We used data from the Korean Community Health Survey (KCHS) conducted by the Korean Center for Disease Control and Prevention in 2018 which included a total of 228340 participants from across the country. We divided the participants into four groups based on their sleep duration and used one-way analysis of variance (ANOVA) to compare the mean values of PHQ-9, BMI, and household income among the groups.Results A total of 227899 respondents were included in the study. Based on a one-way ANOVA, the mean PHQ-9 score tended to increase as sleep duration decreased. However, the group with a sleep duration of 9 hours or more had an exceptionally higher mean PHQ-9 score than the group with a sleep duration of 7 to 9 hours. The BMI score generally decreased as the sleep duration increased. Additionally, the group with a sleep duration of 5 to 7 hours and 7 to 9 hours had higher household income than the group with a sleep duration of 5 hours or less or 9 hours or more.Conclusions This study demonstrated the association between sleep duration and PHQ-9, BMI, and household income. Sleep duration was found to be a factor influencing PHQ-9, BMI, and household income.
背景与目的韩国对睡眠时间与患者健康问卷-9 (PHQ-9)、体重指数(BMI)和收入之间关系的研究较少。本研究旨在探讨睡眠时间与PHQ-9、BMI和家庭收入之间的关系。方法我们使用了韩国疾病控制与预防中心于2018年进行的韩国社区健康调查(KCHS)的数据,其中包括来自全国各地的228340名参与者。我们根据参与者的睡眠时间将他们分为四组,并使用单因素方差分析(ANOVA)比较各组之间PHQ-9、BMI和家庭收入的平均值。结果共纳入调查对象227899人。基于单因素方差分析,平均PHQ-9得分倾向于随着睡眠时间的减少而增加。然而,睡眠时间为9小时或更长一组的PHQ-9平均得分比睡眠时间为7至9小时的一组高得多。BMI指数一般随着睡眠时间的增加而下降。此外,睡眠时间为5至7小时和7至9小时的家庭收入高于睡眠时间为5小时或更少或9小时或更多的家庭收入。结论:本研究证实睡眠时间与PHQ-9、BMI和家庭收入之间存在关联。研究发现,睡眠时间是影响PHQ-9、BMI和家庭收入的一个因素。
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引用次数: 1
Excessive Daytime Sleepiness and Associated Factors Among Women in Perinatal Period 围产期妇女日间过度嗜睡及其相关因素
Q4 Medicine Pub Date : 2023-03-31 DOI: 10.17241/smr.2022.01431
J. Seid, Emam Mohammed, Bilal Mohammed Aman, Hassen Yimer Hassen
Background and Objective Excessive daytime sleepiness (EDS) is an important public health issue requiring adequate screening and management to avoid such harmful consequences. The study aimed to assess the prevalence and risk factors of EDS in the perinatal period.Methods Institution-based cross-sectional study was carried out in selected public health institutions of Ethiopia on systematic selected 362 women during perinatal period. We used a validated Epworth daytime sleepiness tool to collect data. Epi-InfoTM 7 and SPSS version 26 were used for data entry and analysis, respectively. Bivariable and multivariable binary logistic regression analyses were conducted to determine the associated factors.Results The prevalence of EDS was 16.6% (95% CI: 12.6–20.7). Excessive pregnancy-related concern (adjusted odds ratio [AOR] = 0.232, 95% CI: 0.087–0.621), having depression symptoms (AOR = 8.045, 95% CI: 3.375–19.174), anxiety symptoms (AOR = 4.905, 95% CI: 2.083– 11.550) and having a chronic medical illness (AOR = 5.441, 95% CI: 2.273–13.021) were the factors associated with EDS.Conclusions The results of the current study suggested that perinatal EDS among women in northern part of Ethiopia is a highly prevalent and associated with excessive pregnancy concern, depression, anxiety, and medical illness.
背景和目的日间嗜睡(EDS)是一个重要的公共卫生问题,需要进行充分的筛查和管理,以避免此类有害后果。本研究旨在评估围产期EDS的患病率和危险因素。方法在埃塞俄比亚选定的公共卫生机构对362名围产期妇女进行了基于机构的横断面研究。我们使用经过验证的Epworth日间嗜睡工具来收集数据。Epi InfoTM 7和SPSS 26分别用于数据输入和分析。进行双变量和多变量二元逻辑回归分析以确定相关因素。结果EDS的患病率为16.6%(95%CI:12.6-20.7)。过度妊娠相关担忧(调整比值比[AOR]=0.232,95%CI:0.087-0.621),有抑郁症状(AOR=8.045,95%CI:3.375-19.174),焦虑症状(AOR=4.905,95%CI:2.083-11.550)和患有慢性疾病(AOR=5.441,95%CI:2.73-13.021)是与EDS相关的因素。
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引用次数: 0
Association of Sleep Duration and Quality With Health-Related Quality of Life in Fresher University Students 大一学生睡眠时间和质量与健康相关生活质量的关系
Q4 Medicine Pub Date : 2023-03-23 DOI: 10.17241/smr.2022.01389
Ahmad Sharifnezhad, Maryam Garmabi, F. Naderi, Fateme Darrudi, Zahra Andishmand, A. Gholami
Background and Objective Sleep duration and quality are important factors for health-related quality of life (HRQoL). This study aimed at investigating the association of sleep duration and quality with HRQoL in fresher students of Neyshabur University of Medical Sciences. Methods The study included 471 fresher students. The sleep duration and sleep quality were measured with the Persian version of Pittsburgh Sleep Quality Index (PSQI) and the HRQoL was evaluated with the Persian version of the 12-Item Short Form Survey (SF-12). The data were collected from late September to early October in 2019 and 2020. The multiple linear regression model was used to determine the independent association of sleep duration and quality with HRQoL. A p-value ≤ 0.05 was considered statistically significant.
背景和目的睡眠时间和质量是影响健康相关生活质量的重要因素。本研究旨在调查奈沙布尔医学科学大学新生的睡眠时间和质量与HRQoL的关系。方法对471名新生进行问卷调查。睡眠持续时间和睡眠质量用波斯版匹兹堡睡眠质量指数(PSQI)测量,HRQoL用波斯版12项简式调查(SF-12)评估。这些数据是在2019年和2020年9月底至10月初收集的。多元线性回归模型用于确定睡眠时间和质量与HRQoL的独立相关性。p值≤0.05被认为具有统计学意义。
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引用次数: 1
Cheyne-Stokes Breathing With an Obstructive Airway During Rapid Eye Movement Sleep Cheyne Stokes在快速眼动睡眠中的阻塞性气道呼吸
Q4 Medicine Pub Date : 2023-03-23 DOI: 10.17241/smr.2023.01606
K. Ji
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引用次数: 0
Sleep Effort and Insomnia Severity: The Role of Bedtime Procrastination 睡眠努力与失眠严重程度:睡前拖延症的作用
Q4 Medicine Pub Date : 2023-03-23 DOI: 10.17241/smr.2023.01655
O. Uygur, A. Bahar
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引用次数: 1
Reliability and Validity of Dysfunctional Beliefs About Sleep-2 (DBS-2), an Ultra-brief Rating Scale for Assessing Dysfunctional Thoughts About Sleep 睡眠功能障碍信念2(DBS-2)的信度和有效性,这是一种评估睡眠功能障碍信念的超简量表
Q4 Medicine Pub Date : 2022-12-31 DOI: 10.17241/smr.2022.01403
Kyumin Kim, Seockhoon Chung, E. Cho, J. Choi, Dongin Lee, Inn-Kyu Cho
Background and Objective It is important to consider dysfunctional beliefs about sleep when conducting cognitive-behavioral therapy for insomnia. The purpose of this study was to examine the reliability and validity of a Dysfunctional Beliefs about Sleep-2 items (DBS-2) scale in a general population and clinical sample.Methods Our study examined the reliability and validity of the DBS-2 scale in the general population (group I, n = 374) and in a clinical sample of subjects with insomnia disorders (group II, n = 105). An online survey targeting the general population was conducted over the course of January 10–18, 2022, and a retrospective study of medical records was conducted among a clinical sample of insomnia patients who visited the Asan Medical Center Sleep Clinic for the first time between September of 2021 and May of 2022. The internal consistency reliability of the DBS-2 scale was measured using split-half coefficients, and factor analysis was used to determine its validity. Using the Insomnia Severity Index (ISI) and the Dysfunctional Beliefs and Attitudes about Sleep-16 items (DBAS-16), convergence validity was explored.Results Split-half coefficients for the DBS-2 were 0.862 and 0.855 in the general population and a clinical sample of insomnia disorder. DBS-2 overall report score was significantly correlated with ISI (r = 0.26, p < 0.001) and DBAS-16 (r = 0.43, p < 0.001) in the general population, and correlated with ISI (r = 0.45, p < 0.001) and DBAS-16 (r = 0.50, p < 0.001) in the clinical sample. Both groups of subjects had an optimal cut-off score of 13 for the DBS-2 scale.Conclusions We found that the DBS-2 scale, a two-item ultra-brief rating scale, could accurately measure dysfunctional beliefs about sleep in the general population and a clinical sample of insomnia patients.
背景与目的在进行失眠症认知行为治疗时,考虑对睡眠的功能失调信念是很重要的。本研究的目的是检验睡眠功能障碍信念量表(DBS-2)在普通人群和临床样本中的信度和效度。方法本研究检验了DBS-2量表在一般人群(I组,n = 374)和失眠患者临床样本(II组,n = 105)中的信度和效度。在2022年1月10日至18日期间进行了以普通大众为对象的网上调查,并对2021年9月至2022年5月期间首次来到峨山医院睡眠诊疗所的失眠患者的临床样本进行了病历回顾性分析。DBS-2量表内部一致性信度采用分半系数测量,效度采用因子分析确定。采用失眠症严重程度指数(ISI)和关于睡眠-16项的功能失调信念和态度(DBAS-16),探讨收敛效度。结果DBS-2在普通人群和失眠临床样本中的分半系数分别为0.862和0.855。DBS-2总体报告评分与一般人群ISI (r = 0.26, p < 0.001)和DBAS-16 (r = 0.43, p < 0.001)显著相关,与临床样本ISI (r = 0.45, p < 0.001)和DBAS-16 (r = 0.50, p < 0.001)显著相关。两组受试者的DBS-2量表最佳分值为13分。结论DBS-2量表是一种包含两个项目的超简短评定量表,可以准确地衡量普通人群和失眠患者的睡眠功能失调信念。
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引用次数: 2
期刊
Sleep Medicine Research
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