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Obstructive Sleep Apnea in a 2-Year-Old Down Syndrome Child: Successful Management With Adenotonsillectomy Followed by Rapid Maxillary Expansion Treatment 2岁唐氏综合症儿童的阻塞性睡眠呼吸暂停:腺扁桃体切除术后快速上颌扩张治疗的成功管理
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01319
M. J. Park, Y. Kim, Yoo-Sam Chung
Due to glossal and craniofacial skeletal abnormalities, children with Down syndrome (DS) are prone to obstructive sleep apnea (OSA), thus demanding an increased necessity for an earlier diagnosis and more strict control for OSA. Adenotonsillectomy (T&A op) is an effective surgical treatment method to reduce OSA in children. Nevertheless, it should be noted that T&A op in DS children might be insufficient to completely resolve OSA and that extra care is needed when performing a T&A op for airway obstruction in DS during the immediate postoperative period. The objective of the present study was to report a case of a 2-year-old male DS patient with severe OSA (apnea-hypopnea index [AHI] of 61.7/hr) which was consequently reduced to moderate OSA (AHI of 7.6/hr), followed by reduction to mild OSA (AHI of 4.8/hr) with an one-year of rapid maxillary expansion (RME) device application. With a 2-year application of the RME device, the hard palate width in the 1st and 2nd molar region was increased to 5.86 mm and 5.26 mm, respectively. This is the first case report describing that a severe OSA is reduced to moderate OSA with T&A op and further reduced to mild OSA with an RME device application.
由于舌骨和颅面骨骼异常,唐氏综合征(DS)患儿容易发生阻塞性睡眠呼吸暂停(OSA),因此对OSA的早期诊断和严格控制的必要性增加。腺扁桃体切除术(Adenotonsillectomy, T&A op)是减少儿童OSA的有效手术治疗方法。然而,应该注意的是,DS患儿的T&A手术可能不足以完全解决OSA,在DS术后立即进行T&A手术治疗气道阻塞时需要额外的注意。本研究的目的是报告一例2岁男性DS患者,重度OSA(呼吸暂停低通气指数[AHI]为61.7/小时),随后降低为中度OSA (AHI为7.6/小时),随后在使用快速上颌扩张(RME)装置一年后降低为轻度OSA (AHI为4.8/小时)。RME装置使用2年后,第一磨牙区和第二磨牙区硬腭宽度分别增加到5.86 mm和5.26 mm。这是第一个描述重度OSA通过T&A手术降为中度OSA,并通过RME器械进一步降为轻度OSA的病例报告。
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引用次数: 0
Therapeutic Effect of Extended Uvulopalatal Flap Surgery in Patients With Obstructive Sleep Apnea 延长悬垂腭瓣手术治疗阻塞性睡眠呼吸暂停的疗效观察
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01298
Jae-Yoon Kang, Se Yeon Im, Han Wool John Sung, M. Choi, Soo-Kyoung Park, Yong Min Kim
Background and Objective Although numerous studies have reported surgical results of uvulopalatopharyngoplasty, efficacies of extended uvulopalatal flap (EUPF) surgery have only been reported in a few studies. Thus, the aim of this study was to evaluate the success rate of EUPF and investigate the advantage and practicality of this surgery.Methods Medical records of patients who underwent EUPF surgery were retrospectively analyzed. Through medical record analysis, demographic information was confirmed. Postoperative polysomnography (PSG) results were divided into a surgical ‘success’ group and a ‘failure’ group. Patients’ PSG results, questionnaires, and cephalometry were comparatively analyzed.Results All sleep parameters of PSG except rapid eye movement latency and hypopnea index were significantly improved after surgery. Ten patients were in the success group (success rate, 33.3%) and 20 patients were in the failure group. Among preoperative PSG parameters, apnea-hypopnea index, apnea index, and number of awakenings showed significant differences between the two groups. However, there were no significant differences in results of cephalometry or Friedman stage between the two groups.Conclusions The EUPF surgery can change sleep factors and improve subjective symptoms in obstructive sleep apnea patients. It could be considered as one of the treatment options for patients with surgical indications, although its success rate was only 33.3%.
背景与目的虽然有大量研究报道了悬垂腭咽成形术的手术效果,但扩展悬垂腭瓣(EUPF)手术的效果仅在少数研究中报道。因此,本研究的目的是评估EUPF的成功率,并探讨该手术的优势和实用性。方法回顾性分析EUPF手术患者的病历资料。通过病案分析,确认了人口统计信息。术后多导睡眠图(PSG)结果分为手术“成功”组和“失败”组。比较分析患者的PSG结果、问卷调查和头颅测量。结果术后除快速眼动潜伏期和低通气指数外,其余睡眠参数均有明显改善。成功组10例(成功率33.3%),失败组20例。术前PSG参数中,两组间呼吸暂停低通气指数、呼吸暂停指数、苏醒次数差异有统计学意义。然而,两组之间在头测术和Friedman分期的结果没有显著差异。结论EUPF手术可改变阻塞性睡眠呼吸暂停患者的睡眠因素,改善其主观症状。对于有手术指征的患者,可考虑作为治疗方案之一,但成功率仅为33.3%。
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引用次数: 0
Effect of Atypical Antipsychotic Medications on the Risk of Obstructive Sleep Apnea in Individuals With Schizophrenia 非典型抗精神病药物对精神分裂症患者阻塞性睡眠呼吸暂停风险的影响
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01326
Habibolah Khazaie, Siamand Mazhar, A. Moghadam, M. R. Ghadami, Sepideh Khazaie, A. Parvizifard
Background and Objective Weight gain and obesity could be side effects of taking atypical antipsychotic medications. They are major risk factors for obstructive sleep apnea. The purpose of this study was to investigate effects of atypical antipsychotic medications on the risk of obstructive sleep apnea in individuals with schizophrenia and control groups.Methods In this cross-sectional study, 123 patients with schizophrenia and 107 participants were selected from hospital staff and students using purposive sampling. Data were collected using structured clinical interview and Berlin questionnaires.Results Results showed that the risk of obstructive sleep apnea was significantly higher in individuals with schizophrenia. Age, body mass index, and phases of schizophrenia showed meaningful relationships with the duration of taking atypical antipsychotic medications with the risk of obstructive sleep apnea. However, the type of atypical antipsychotic medications did not have a significant relationship with the risk of obstructive sleep apnea.Conclusions Patients with schizophrenia treated with atypical antipsychotic medicationshave a higher risk of obstructive sleep apnea.
背景与目的体重增加和肥胖可能是服用非典型抗精神病药物的副作用。它们是阻塞性睡眠呼吸暂停的主要危险因素。本研究的目的是调查非典型抗精神病药物对精神分裂症患者和对照组阻塞性睡眠呼吸暂停风险的影响。方法采用目的抽样的方法,从医院工作人员和学生中抽取123例精神分裂症患者和107名被试。数据收集采用结构化临床访谈和柏林问卷。结果结果显示,精神分裂症患者出现阻塞性睡眠呼吸暂停的风险明显较高。年龄、身体质量指数和精神分裂症的阶段与服用非典型抗精神病药物的持续时间与阻塞性睡眠呼吸暂停的风险之间存在有意义的关系。然而,非典型抗精神病药物的类型与阻塞性睡眠呼吸暂停的风险没有显著关系。结论非典型抗精神病药物治疗的精神分裂症患者发生阻塞性睡眠呼吸暂停的风险较高。
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引用次数: 1
The Incidence of Renal Cell Carcinoma Is Increased in Patients With Obstructive Sleep Apnea 阻塞性睡眠呼吸暂停患者肾癌的发病率增加
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01305
H. Park, W. Choi, J. Cho
Background and Objective Many studies have indicated that obstructive sleep apnea (OSA) is linked to the development of cancer. However, there have been few studies about the link between OSA and renal cell carcinoma (RCC). This study investigated the relationship between OSA and RCC by analyzing the data from the Korea National Health Insurance Service.Methods 198574 patients (≥ 20 years of age) newly diagnosed with OSA from 2007 to 2014 were included and 992870 control groups were selected through propensity score matching according to sex and age. The average follow-up period was 4.6 years. The primary outcome was newly diagnosed RCC. The hazard ratio for RCC in patients with OSA was compared to that in the control group.Results The incidence of RCC was significantly higher among patients with OSA than among controls (hazard ratio, 1.65; 95% confidence interval, 1.41–1.93).Conclusions OSA may be a potential risk factor for RCC.
背景与目的许多研究表明,阻塞性睡眠呼吸暂停(OSA)与癌症的发生有关。然而,关于OSA与肾细胞癌(RCC)之间关系的研究很少。本研究通过分析韩国国民健康保险公团的数据,探讨OSA与RCC之间的关系。方法纳入2007 - 2014年新确诊OSA患者198574例(≥20岁),按性别、年龄进行倾向评分匹配,选择对照组992870例。平均随访时间为4.6年。主要终点为新诊断的肾细胞癌。将OSA患者的RCC风险比与对照组进行比较。结果OSA患者的RCC发生率明显高于对照组(风险比1.65;95%置信区间,1.41-1.93)。结论OSA可能是RCC的潜在危险因素。
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引用次数: 0
Postural Effect on Obstructive Sleep Apnea: Sitting Versus Supine 姿势对阻塞性睡眠呼吸暂停的影响:坐与仰卧
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01312
K. Ji
Postural effects on breathing are evident in most patients with obstructive sleep apnea. However, the impact varies depending on an individual’s habitual sleeping position. Here, an age 40 obese male with typical sleep apnea symptoms is presented. He had a habit of sleeping with his back on the head of the bed in a sitting position, two or three times nightly. Polysomnography showed severe obstructive sleep apnea. However, during sitting positional sleep, the obstructive events disappeared, and sleep became stable.
姿势对呼吸的影响在大多数阻塞性睡眠呼吸暂停患者中是明显的。然而,影响因个人习惯的睡姿而异。这里,一个40岁的肥胖男性与典型的睡眠呼吸暂停症状。他有一种习惯,一晚上睡两三次,仰卧在床头。多导睡眠图显示严重的阻塞性睡眠呼吸暂停。然而,在坐姿睡眠中,阻碍事件消失,睡眠变得稳定。
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引用次数: 0
The High-Dose of Exogenous Melatonin Did Not Alter the Sleep-Wake Cycle in Anoxic Brain Injury Patients 高剂量外源性褪黑素不会改变缺氧性脑损伤患者的睡眠-觉醒周期
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01361
M. Kanarskii, J. Nekrasova, Pranil M. Pradhan, I. Borisov, O. Korepina, E. Kondratyeva, Angelina Nikitkina, Marina Petrova
Disturbance in circadian rhythms and the sleep-wake cycle is typical for patients in the intensive care unit, which retards rehabilitation. To assess the effect of exogenous melatonin and simultaneous mitigation of intensive care unit environmental factors on sleep duration. We studied five patients with chronic disorder of consciousness caused by anoxic brain injury. In addition, we varied the level of melatonin secretion in blood plasma to assess melatonin’s bioavailability and elimination time. We evaluated the sleep-wake cycle using continuous videoelectroencephalogram monitoring with the addition of oculographic and myographic channels for 72 hours. All the patients received melatonin tablets on the second day, wore masks and ear plugs, and had no feeding and nursing manipulations at night on the second and third days. There was no significant difference in sleep time between the first, second, and third days. Future studies of the circadian rhythm should aim at gaining a deeper analysis of the characteristics of the sleep-wake cycle in patients with severe anoxic brain injury together with further research for possible ways to influence the circadian component of sleep.
昼夜节律和睡眠-觉醒周期的紊乱是重症监护室患者的典型症状,这会阻碍康复。评估外源性褪黑素和同时缓解重症监护室环境因素对睡眠时间的影响。我们研究了5名缺氧性脑损伤引起的慢性意识障碍患者。此外,我们还改变了血浆中褪黑素的分泌水平,以评估褪黑素的生物利用度和消除时间。我们使用连续视频脑电图监测来评估睡眠-觉醒周期,并添加眼图和肌电图通道72小时。所有患者在第二天服用褪黑素片,戴口罩和耳塞,第二天和第三天晚上没有进食和护理操作。第一天、第二天和第三天的睡眠时间没有显著差异。未来对昼夜节律的研究应旨在对严重缺氧性脑损伤患者的睡眠-觉醒周期特征进行更深入的分析,并进一步研究影响睡眠昼夜节律成分的可能方法。
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引用次数: 0
The DBST Index, the Discrepancy Between Desired Time in Bed and Desired Total Sleep Time: The Possible New Sleep Index Predicting Severity of Insomnia DBST指数,期望卧床时间和期望总睡眠时间之间的差异:预测失眠严重程度的可能的新睡眠指数
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01368
Seockhoon Chung
Background and Objective We considered the concept of the DBST, the discrepancy between a patient’s desired time in bed (TIB) and desired total sleep time (TST). The DBST index can be used to easily assess a patient’s thoughts on their desired TST and dysfunctionally long TIB. This study aimed to explore whether the DBST index can predict the severity of insomnia.Methods A total of 374 members of the general population participated in this e-survey study. The participants answered questions regarding their bedtime, sleep onset time, wake-up time, desired TST, and desired TIB, and psychological symptoms were assessed using the Insomnia Severity Index (ISI), Patients Health Questionnaire–9 items (PHQ-9), Dysfunctional Beliefs and Attitudes about Sleep–16 items (DBAS-16), and Glasgow Sleep Effort Scale (GSES).Results The DBST index was significantly correlated with the ISI (r = 0.20, p < 0.01), PHQ-9 (r = 0.15, p < 0.01), GSES (r = 0.14, p < 0.01), DBAS-16 (r = 0.16, p < 0.01), desired TST (r = -0.62, p < 0.01), and desired TIB (r = 0.52, p < 0.01). Linear regression analysis showed that insomnia severity was predicted by persistent preoccupation with sleep (beta = 0.64, p < 0.001), dysfunctional beliefs about sleep (beta = 0.06, p < 0.001), depression (beta = 0.23, p < 0.001), and DBST (beta = 0.32, p = 0.035). The DBST directly influenced insomnia severity, and this association was shown to be mediated by dysfunctional beliefs and attitudes about sleep, preoccupation with sleep, and depression.Conclusions The DBST index could be a possible new sleep index due to its relationship with insomnia severity, depression, dysfunctional beliefs about sleep, and preoccupation with sleep. Further studies are needed to explore the consistency of the clinical sample.
背景与目的我们考虑了DBST的概念,即患者期望的卧床时间(TIB)和期望的总睡眠时间(TST)之间的差异。DBST指数可以用来很容易地评估患者对他们期望的TST和功能失调的长TIB的想法。本研究旨在探讨DBST指数是否可以预测失眠的严重程度。方法对374名普通人群进行电子问卷调查。参与者回答有关就床时间、睡眠开始时间、起床时间、期望TST和期望TIB的问题,并使用失眠严重程度指数(ISI)、患者健康问卷-9项(PHQ-9)、睡眠功能失调信念和态度-16项(bas -16)和格拉斯哥睡眠努力量表(GSES)评估心理症状。结果DBST指数与ISI (r = 0.20, p < 0.01)、PHQ-9 (r = 0.15, p < 0.01)、GSES (r = 0.14, p < 0.01)、DBAS-16 (r = 0.16, p < 0.01)、理想TST (r = -0.62, p < 0.01)、理想TIB (r = 0.52, p < 0.01)显著相关。线性回归分析显示,持续关注睡眠(β = 0.64, p < 0.001)、对睡眠的功能失调信念(β = 0.06, p < 0.001)、抑郁(β = 0.23, p < 0.001)和DBST (β = 0.32, p = 0.035)可以预测失眠严重程度。DBST直接影响失眠的严重程度,这种关联被证明是由对睡眠的功能失调的信念和态度、对睡眠的关注和抑郁介导的。结论DBST指数与失眠严重程度、抑郁程度、睡眠信念功能障碍和睡眠关注相关,可能成为一种新的睡眠指数。临床样本的一致性有待进一步研究。
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引用次数: 2
Surgical Outcomes for Obstructive Sleep Apnea in Korea 韩国阻塞性睡眠呼吸暂停的手术结果
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.17241/smr.2022.01424
Minkyeong Lee, Jae Yong Lee, J. Choi
Obstructive sleep apnea (OSA) is a common chronic sleep disorder that causes oxygen desaturations, sympathetic hyperactivation, and sleep fragmentation. The gold standard for OSA treatment in adults is positive airway pressure (PAP) therapy, which is effective when used during sleep. However, about half of patients with OSA refuse or are non-adherent to PAP, and some patients have anatomical problems that can be alleviated surgically. Surgery can be considered for patients who are very likely to have successful surgical results, but who are intolerant to PAP or oral appliances because of anatomical abnormalities. There are various surgical modifications of the upper airway for OSA, including nasal surgeries (e.g., septoplasty, turbinoplasty, and endoscopic sinus surgery), nasopharyngeal surgeries, oral and oropharyngeal surgeries (e.g., uvulopalatopharyngoplasty and variations, tonsillectomy, and palatal implants), hypopharyngeal surgeries (e.g., tongue ablation, tongue-base resection, and genioglossus advancement), and multi-level surgeries. Much clinical research has reported the outcomes of various surgical procedures for OSA internationally based on the traditional surgical success rate (defined as ≥ 50% reduction in the postoperative apnea-hypopnea index [AHI], postoperative AHI < 20), and AHI reduction ratio (defined as between the preoperative and postoperative AHI). In addition, many studies investigating the results of various OSA surgeries have been reported in Korea. In this article, we review the characteristics of various upper airway surgical procedures for OSA, global surgical results for OSA, and current surgical outcomes for OSA in Korea.
阻塞性睡眠呼吸暂停(OSA)是一种常见的慢性睡眠障碍,可导致氧饱和度降低、交感神经过度激活和睡眠破碎。成人阻塞性睡眠呼吸暂停治疗的金标准是气道正压(PAP)治疗,在睡眠期间使用是有效的。然而,大约一半的OSA患者拒绝或不坚持PAP,一些患者存在解剖问题,可以通过手术缓解。对于那些很可能获得成功的手术结果,但由于解剖异常而对PAP或口腔器械不耐受的患者,可以考虑手术。阻塞性睡眠呼吸暂停有多种上气道手术修饰,包括鼻手术(如鼻中隔成形术、鼻甲成形术和内窥镜鼻窦手术)、鼻咽手术、口腔和口咽手术(如悬垂腭咽部成形术和变形术、扁桃体切除术和腭种植术)、下咽手术(如舌消融、舌底切除术和颏舌肌推进术)和多层手术。国际上已有大量临床研究报道了基于传统手术成功率(定义为术后呼吸暂停低通气指数[AHI]降低≥50%,术后AHI < 20)和AHI降低率(定义为术前和术后AHI之间)的各种OSA手术方式的结果。此外,国内也报道了许多调查各种阻塞性睡眠呼吸暂停手术结果的研究。在这篇文章中,我们回顾了各种上呼吸道手术治疗OSA的特点,全球OSA的手术结果,以及目前韩国OSA的手术结果。
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引用次数: 2
Insomnia Mediate the Influence of Reassurance-Seeking Behavior and Viral Anxiety on Preoccupation With COVID-19 Among the General Population 在普通人群中,失眠介导安抚-注视行为和病毒性焦虑对新冠肺炎预防的影响
Q4 Medicine Pub Date : 2022-07-08 DOI: 10.17241/smr.2022.01291
E. Cho, Dongin Lee, Inn-Kyu Cho, Joohee Lee, J. Ahn, Y. Bang
Background and Objective We explored in this study whether insomnia, viral anxiety, reassurance-seeking behavior, and preoccupation with coronavirus disease (COVID-19) are related among the general population. As well, we explored the possibility that insomnia may mediate the association between COVID-19 viral anxiety and preoccupation. Methods During November 9-15, 2021, 400 participants voluntarily completed this survey, and participants' age, sex, living location, and marital status were collected. Responses to questions about COVID-19 were also gathered, and their symptoms were rated using the Obsession with COVID-19 Scale (OCS), Coronavirus Reassurance-Seeking Behaviors Scale (CRBS), Fear of COVID-19 scale (FCV-19S), and Insomnia Severity Index (ISI). Results Preoccupation with COVID-19 was predicted by young age (beta = -0.08, p = 0.012), CRBS (beta = 0.52, p < 0.001), FCV-19S (beta = 0.30, p < 0.001), and ISI (beta = 0.07, p = 0.029) (adjusted R2 = 0.62, F = 163.6, p < 0.001). Mediation analysis showed that insomnia partially mediates the influence of reassurance seeking behavior and viral anxiety on preoccupation with COVID-19. Conclusions Sleep disturbances can contribute to a vicious cycle of hypochondriacal preoccupation with COVID-19. In order to reduce an individual's viral anxiety, insomnia symptoms must be addressed. Copyright © 2022 The Korean Society of Sleep Medicine
背景与目的探讨失眠、病毒性焦虑、寻求安慰行为和对冠状病毒疾病(新冠肺炎)的专注是否与普通人群有关。此外,我们还探讨了失眠可能介导新冠肺炎病毒性焦虑与专注之间的联系的可能性。方法在2021年11月9日至15日期间,400名参与者自愿完成了这项调查,并收集了参与者的年龄、性别、居住地点和婚姻状况。还收集了对新冠肺炎问题的回答,并使用新冠肺炎困扰量表(OCS)、冠状病毒安抚-注视行为量表(CRBS)、新冠肺炎恐惧量表(FCV-19S)和失眠严重程度指数(ISI)对其症状进行评分。结果年轻(β=0.08,p=0.012)、CRBS(β=0.52,p<0.001)、FCV-19S(β=0.30,p<001)和ISI(β=0.07,p=0.029)(调整后的R2=0.62,F=163.6,p<0.01)预测了新冠肺炎的提前。中介分析表明,失眠部分介导了寻求安慰行为和病毒性焦虑对新冠肺炎的影响。结论睡眠障碍可导致新冠肺炎伴疑病症的恶性循环。为了减少个人的病毒性焦虑,必须解决失眠症状。版权所有©2022韩国睡眠医学会
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引用次数: 4
Effects of Melatonin on Sleep Quality and Disease Activity in Patients With Rheumatoid Arthritis 褪黑素对类风湿关节炎患者睡眠质量和疾病活动度的影响
Q4 Medicine Pub Date : 2022-06-30 DOI: 10.17241/smr.2022.01207
Tayebeh Palimi, M. Zilaee, Elham Rajaei, M. Karandish
Background and Objective In rheumatoid arthritis (RA) patients sleep disturbance is one of serious and prevalent problems. Considering the known effects of melatonin on sleep quality and inflammation, this study aimed to investigate melatonin supplementation effect on quality of sleep and disease activity in patients with RA.Methods In this randomized, placebo-controlled trial (double-blind), 64 RA patients were selected and divided into experimental and placebo groups randomly; experimental group received 3 mg/d of melatonin and another group consumed placebo for 60 days. Before and after the investigation, assessment of the quality of sleep determined using the Pittsburgh Sleep Quality Index (PSQI). Disease Activity Score-28 (DAS28) and the Visual Analogue Scale (VAS) questionnaires were used for evaluation of disease activity and pain intensity, respectively.Results Melatonin significantly reduced PSQI, DAS28 and VAS scores, when values compared with baseline. In contrast to placebo group, good sleep quality within the melatonin group increased significantly compared to baseline and this improvement in sleep quality was significant when compared between groups. The scores of DAS28 and pain VAS at the end of trial were significantly reduced compared to the baseline in both groups. However, reduction in the DAS28 and VAS scores of the melatonin group were stronger than reductions in the placebo receiving group.Conclusions This study results revealed that melatonin was safe and effective in improving sleep quality and reducing DAS28 and pain VAS scores in RA patients.
背景与目的类风湿性关节炎(RA)患者睡眠障碍是一个严重而普遍的问题。考虑到褪黑素对睡眠质量和炎症的影响,本研究旨在研究补充褪黑素对RA患者睡眠质量和疾病活动的影响;实验组服用褪黑素3mg/d,另一组服用安慰剂60天。在调查前后,使用匹兹堡睡眠质量指数(PSQI)确定睡眠质量评估。疾病活动性评分-28(DAS28)和视觉模拟量表(VAS)问卷分别用于评估疾病活动性和疼痛强度。结果与基线相比,褪黑素可显著降低PSQI、DAS28和VAS评分。与安慰剂组相比,褪黑素组的良好睡眠质量与基线相比显著提高,并且与各组相比,这种睡眠质量的改善是显著的。试验结束时,两组的DAS28和疼痛VAS评分与基线相比均显著降低。然而,褪黑激素组的DAS28和VAS评分的下降幅度大于安慰剂组的下降幅度。结论本研究结果表明,褪黑素在改善RA患者睡眠质量、降低DAS28和疼痛VAS评分方面是安全有效的。
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引用次数: 0
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Sleep Medicine Research
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