Pub Date : 2025-11-08DOI: 10.1016/j.jorganchem.2025.123938
Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , M.A. Diab , Heba A. El-Sabban
In this inclusive innovation study, we developed a new green way to create bio-decorated palladium nanoparticles using an extract from orange leaves over the magnetic Fe3O4 NPs to make a novel nanocatalyst. The orange leaf extract served as a green reducing agent and was great at keeping the stability of the nanoparticles we generated. Then, the produced Fe3O4/Pd NPs was carefully studied with different tests like FE-SEM, TEM, EDX, XRD, ICP-OES, and VSM. The desired Fe3O4/Pd NPs showed impressive activity for N-arylation of indole with iodo-arenes through a reaction called Ullmann-type C-N coupling. Different aryl halides were converted to N-arylated indoles with good results for aryl iodides and moderate yields for aryl bromides. Additionally, the Fe3O4/Pd NPs could be recovered and reused for 6 times with maintaining their effectiveness.
{"title":"Bio-inspired synthesis of a recyclable magnetic palladium nanocatalyst for C-N coupling reactions","authors":"Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , M.A. Diab , Heba A. El-Sabban","doi":"10.1016/j.jorganchem.2025.123938","DOIUrl":"10.1016/j.jorganchem.2025.123938","url":null,"abstract":"<div><div>In this inclusive innovation study, we developed a new green way to create bio-decorated palladium nanoparticles using an extract from <em>orange</em> leaves over the magnetic Fe<sub>3</sub>O<sub>4</sub> NPs to make a novel nanocatalyst. The <em>orange</em> leaf extract served as a green reducing agent and was great at keeping the stability of the nanoparticles we generated. Then, the produced Fe<sub>3</sub>O<sub>4</sub>/Pd NPs was carefully studied with different tests like FE-SEM, TEM, EDX, XRD, ICP-OES, and VSM. The desired Fe<sub>3</sub>O<sub>4</sub>/Pd NPs showed impressive activity for <em>N</em>-arylation of indole with iodo-arenes through a reaction called Ullmann-type C-N coupling. Different aryl halides were converted to <em>N</em>-arylated indoles with good results for aryl iodides and moderate yields for aryl bromides. Additionally, the Fe<sub>3</sub>O<sub>4</sub>/Pd NPs could be recovered and reused for 6 times with maintaining their effectiveness.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123938"},"PeriodicalIF":2.1,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.jorganchem.2025.123936
Daria A. Burmistrova , Nadezhda P. Pomortseva , Yulia K. Voronina , Andrey I. Poddel'sky , Nadezhda T. Berberova , Igor L. Eremenko , Arthur S. Vashurin , Ivan V. Smolyaninov
New diorganotin(IV) complexes R2Sn(Ln) 1–5 (where R = Et, t-Bu, Ph) with O,N,S-donor tridentate Schiff bases containing chlorine or trifluoromethyl groups were synthesized in 49–67% yields. Compounds 1–5 were characterized by 1H, 13C NMR, IR spectroscopy, and elemental analysis. The molecular structures of 2, 3, and 5 in the crystalline state were determined by single-crystal X-ray diffraction. The organotin complexes are mononuclear and five-coordinate, with ligands adopting a dianionic form. Electrochemical studies revealed that the electrooxidation process is irreversible while the electrochemical reduction generates relatively stable monoanionic complexes. Complex 3, along with previously reported related phenyl- or ethyl-substituted tin compounds, exhibits luminescence in chloroform. The radical scavenging activity of the complexes was evaluated in reactions with ABTS radical cation or superoxide radical anion in NBT assay. The highest neutralizing properties were observed for complexes with ethyl substituents at tin atom; their IC₅₀ values ranged from 6 to 35 µM. In the oxidative DNA damage assays, most compounds exhibited a promoting effect suggesting their potential role in DNA cleavage under oxidative stress. However, in the lipid peroxidation model reaction in vitro, an antioxidant effect was observed for most compounds, particularly for hydrophobic tert‑butyl‑containing complexes 2 and 4.
{"title":"Synthesis and characterization of R2Sn(IV)L complexes with O,N,S-tridentate Schiff base ligands: Electrochemistry, photophysical properties and antioxidant activity","authors":"Daria A. Burmistrova , Nadezhda P. Pomortseva , Yulia K. Voronina , Andrey I. Poddel'sky , Nadezhda T. Berberova , Igor L. Eremenko , Arthur S. Vashurin , Ivan V. Smolyaninov","doi":"10.1016/j.jorganchem.2025.123936","DOIUrl":"10.1016/j.jorganchem.2025.123936","url":null,"abstract":"<div><div>New diorganotin(IV) complexes R<sub>2</sub>Sn(L<sup>n</sup>) <strong>1</strong>–<strong>5</strong> (where <em>R</em> = Et, t-Bu, Ph) with O,N,S-donor tridentate Schiff bases containing chlorine or trifluoromethyl groups were synthesized in 49–67% yields. Compounds <strong>1–5</strong> were characterized by <sup>1</sup>H, <sup>13</sup>C NMR, IR spectroscopy, and elemental analysis. The molecular structures of <strong>2, 3</strong>, and <strong>5</strong> in the crystalline state were determined by single-crystal X-ray diffraction. The organotin complexes are mononuclear and five-coordinate, with ligands adopting a dianionic form. Electrochemical studies revealed that the electrooxidation process is irreversible while the electrochemical reduction generates relatively stable monoanionic complexes. Complex <strong>3</strong>, along with previously reported related phenyl- or ethyl-substituted tin compounds, exhibits luminescence in chloroform. The radical scavenging activity of the complexes was evaluated in reactions with ABTS radical cation or superoxide radical anion in NBT assay. The highest neutralizing properties were observed for complexes with ethyl substituents at tin atom; their IC₅₀ values ranged from 6 to 35 µM. In the oxidative DNA damage assays, most compounds exhibited a promoting effect suggesting their potential role in DNA cleavage under oxidative stress. However, in the lipid peroxidation model reaction in vitro, an antioxidant effect was observed for most compounds, particularly for hydrophobic <em>tert</em>‑butyl‑containing complexes <strong>2</strong> and <strong>4</strong>.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123936"},"PeriodicalIF":2.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-06DOI: 10.1016/j.jorganchem.2025.123933
Pierre Arnaut , Christophe Vos , Dirk De Vos , Steven P. Nolan , Catherine S.J. Cazin
Catalyst stability is one of many challenges encountered in olefin metathesis. Herein, we probe the behavior of first and second-generation alkene metathesis catalysts as a function of pressure and temperature in the ethenolysis of polybutadiene. Experimental data indicates that increased steric hindrance on the ancillary ligand tends to reduce decomposition pathways, as emphasized by the decrease of activity at high pressure and temperature with the SIMes ligand compared to SIPr.
{"title":"The role of supporting ligands in Ruthenium-mediated ethenolysis reactions","authors":"Pierre Arnaut , Christophe Vos , Dirk De Vos , Steven P. Nolan , Catherine S.J. Cazin","doi":"10.1016/j.jorganchem.2025.123933","DOIUrl":"10.1016/j.jorganchem.2025.123933","url":null,"abstract":"<div><div>Catalyst stability is one of many challenges encountered in olefin metathesis. Herein, we probe the behavior of first and second-generation alkene metathesis catalysts as a function of pressure and temperature in the ethenolysis of polybutadiene. Experimental data indicates that increased steric hindrance on the ancillary ligand tends to reduce decomposition pathways, as emphasized by the decrease of activity at high pressure and temperature with the SIMes ligand compared to SIPr.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123933"},"PeriodicalIF":2.1,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05DOI: 10.1016/j.jorganchem.2025.123934
Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P.R. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , Mustafa Diab , H. Amin El Sabban
In this incusive innoviation work, a nanomaterial of copper nanoparticles immobilized over cross-linked chitosan-modified zinc oxide particles (ZnO@CS-GA/Cu NPs) was created by a green and cost-effective procedure assisted by green tea extract. To confirm that it was made correctly, various tests were conducted including FE-SEM, EDX, XRD, TEM, elemental mapping, and ICP-OES studies. After identifying the characteristics of ZnO@CS-GA/Cu NPs, its catalytic performance was evaluated for making aromatic sulfides through C-S coupling condensation. Importantly, the desired catalyst showed good recyclability, retaining its performance for 7 runs without suffering a significant decrease in activity.
{"title":"Copper nanoparticles supported over the chitosan modified zinc oxide nanocomposite: Investigation of its catalytic efficiency for C-S coupling reactions","authors":"Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P.R. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , Mustafa Diab , H. Amin El Sabban","doi":"10.1016/j.jorganchem.2025.123934","DOIUrl":"10.1016/j.jorganchem.2025.123934","url":null,"abstract":"<div><div>In this incusive innoviation work, a nanomaterial of copper nanoparticles immobilized over cross-linked chitosan-modified zinc oxide particles (ZnO@CS-GA/Cu NPs) was created by a green and cost-effective procedure assisted by <em>green tea</em> extract. To confirm that it was made correctly, various tests were conducted including FE-SEM, EDX, XRD, TEM, elemental mapping, and ICP-OES studies. After identifying the characteristics of ZnO@CS-GA/Cu NPs, its catalytic performance was evaluated for making aromatic sulfides through C-S coupling condensation. Importantly, the desired catalyst showed good recyclability, retaining its performance for 7 runs without suffering a significant decrease in activity.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123934"},"PeriodicalIF":2.1,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05DOI: 10.1016/j.jorganchem.2025.123935
Takudzwa E. Murwira , Gregory S. Smith , Ramona Hurdayal
Currently available drugs for cutaneous leishmaniasis are sub-optimal due to parasite-specific drug resistance, drug-induced host toxicity and lengthy treatment. Repurposing existing drugs/compounds with established biological activity provides an attractive measure for antileishmanial drug development. Quinoline is a ubiquitous scaffold for targeting parasitic infections, particularly malaria, showing enhanced activity when combined with metal complexes, such as the iron-containing compound ferrocene. Concomitantly, this study evaluates the potential of ferrocenyl-quinoline compounds as potential drug candidates for treating cutaneous leishmaniasis caused by Leishmania major, focusing on in vitro antipromastigote activity and cytotoxicity, using murine and cell-based models of the disease. Four ferrocenyl-quinoline compounds containing various linkers (imino-alkyl, amino-alkyl, triazole-amine and phenyl-alkene) were synthesized, with the triazole-amine and phenyl-alkene compounds being new. The four compounds and their respective precursors were assessed for their antileishmanial activity against the promastigote form of L. major LV39, as well as their cytotoxicity in the RAW 264.7 murine macrophage cell line. The amino-alkyl and triazole amine-linked compounds were the most active against L. major LV39 promastigotes (IC50 = 1.16 and 8.83 μM, respectively), with the former being more active than the clinical drug, amphotericin B (IC50 = 2.10 μM). All four ferrocenyl-quinoline compounds were more cytotoxic than amphotericin B (CC50 < 54 μM). However, both the amino-alkyl and triazole amine-linked compounds showed higher CC50 values than their respective IC50 values, suggesting a higher selectivity toward L. major promastigotes than their other counterparts (SI > 1). The triazole amine-linked compound, in particular, had an SI of 2.11, making it a more promising antileishmanial agent worthy of further investigation. This preliminary study not only delineates structure-based trends on antipromastigote activity but also demonstrates the significance of incorporating metals in drug design to enhance potency. Additional future studies are necessary to examine the potency of these compounds against L. major amastigotes, as well as their efficacy in vivo and mechanism of action.
由于寄生虫特有的耐药性、药物诱导的宿主毒性和治疗时间过长，目前可用于皮肤利什曼病的药物不是最理想的。重新利用具有既定生物活性的现有药物/化合物为抗利什曼病药物开发提供了一种有吸引力的措施。喹啉是一种普遍存在的靶向寄生虫感染的支架，特别是疟疾，当与金属配合物结合时，如含铁化合物二茂铁，显示出增强的活性。同时，本研究评估了二茂铁-喹啉化合物作为治疗主要利什曼原虫引起的皮肤利什曼病的潜在候选药物的潜力，重点关注体外抗原鞭毛菌活性和细胞毒性，使用小鼠和基于细胞的疾病模型。合成了四种含亚胺烷基、氨基烷基、三唑胺和苯基烯烃的二茂铁喹啉化合物，其中三唑胺和苯基烯烃为新化合物。研究了这四种化合物及其各自的前体对L. major LV39 promastigote形式的抗利什曼原虫活性，以及它们在RAW 264.7小鼠巨噬细胞中的细胞毒性。氨基烷基和三唑胺类化合物对L. major LV39 promastigotes活性最强（IC50分别为1.16和8.83 μM），前者的活性高于临床药物两性霉素B （IC50 = 2.10 μM）。四种二茂铁喹啉化合物的细胞毒性均高于两性霉素B （CC50 < 54 μM）。然而，氨基烷基和三唑胺联化合物的CC50值均高于其各自的IC50值，表明它们对L. major promastigotes的选择性高于其他化合物（SI > 1）。特别是三唑胺连接的化合物，其SI值为2.11，是一种更有前途的抗利什曼病药物，值得进一步研究。这一初步研究不仅描绘了基于结构的抗promastigote活性的趋势，而且表明了在药物设计中加入金属以提高效力的意义。进一步的研究需要进一步研究这些化合物对L. major amastigotes的效力，以及它们在体内的作用和作用机制。
{"title":"Exploring ferrocenyl-quinoline hybrids as in vitro agents against Leishmania major promastigotes","authors":"Takudzwa E. Murwira , Gregory S. Smith , Ramona Hurdayal","doi":"10.1016/j.jorganchem.2025.123935","DOIUrl":"10.1016/j.jorganchem.2025.123935","url":null,"abstract":"<div><div>Currently available drugs for cutaneous leishmaniasis are sub-optimal due to parasite-specific drug resistance, drug-induced host toxicity and lengthy treatment. Repurposing existing drugs/compounds with established biological activity provides an attractive measure for antileishmanial drug development. Quinoline is a ubiquitous scaffold for targeting parasitic infections, particularly malaria, showing enhanced activity when combined with metal complexes, such as the iron-containing compound ferrocene. Concomitantly, this study evaluates the potential of ferrocenyl-quinoline compounds as potential drug candidates for treating cutaneous leishmaniasis caused by <em>Leishmania major</em>, focusing on <em>in vitro</em> antipromastigote activity and cytotoxicity, using murine and cell-based models of the disease. Four ferrocenyl-quinoline compounds containing various linkers (imino-alkyl, amino-alkyl, triazole-amine and phenyl-alkene) were synthesized, with the triazole-amine and phenyl-alkene compounds being new. The four compounds and their respective precursors were assessed for their antileishmanial activity against the promastigote form of <em>L. major</em> LV39, as well as their cytotoxicity in the RAW 264.7 murine macrophage cell line. The amino-alkyl and triazole amine-linked compounds were the most active against <em>L. major</em> LV39 promastigotes (IC<sub>50</sub> = 1.16 and 8.83 μM, respectively), with the former being more active than the clinical drug, amphotericin B (IC<sub>50</sub> = 2.10 μM). All four ferrocenyl-quinoline compounds were more cytotoxic than amphotericin B (CC<sub>50</sub> < 54 μM). However, both the amino-alkyl and triazole amine-linked compounds showed higher CC<sub>50</sub> values than their respective IC<sub>50</sub> values, suggesting a higher selectivity toward <em>L. major</em> promastigotes than their other counterparts (SI > 1). The triazole amine-linked compound, in particular, had an SI of 2.11, making it a more promising antileishmanial agent worthy of further investigation. This preliminary study not only delineates structure-based trends on antipromastigote activity but also demonstrates the significance of incorporating metals in drug design to enhance potency. Additional future studies are necessary to examine the potency of these compounds against <em>L. major</em> amastigotes, as well as their efficacy <em>in vivo</em> and mechanism of action.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123935"},"PeriodicalIF":2.1,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jorganchem.2025.123932
Barbara C. Higgs , Bre-Anna N. Willis , Vinesah A.M. Goodwin , Gaël Ung , Colin D. McMillen , Eloise K. Burick , Jorge Barroso , Jared A. Pienkos
The N-oxide functional group is commonly utilized in medicinal applications (i.e., imaging agents); however, its presence in transition metal chemistry is limited. To investigate the impact of an N-oxide functional group on the properties of organometallic complexes, N-oxide-containing Ir(III) and Ru(II) heteroleptic transition metal complexes and corresponding non-N-oxide congeners were synthesized (yields > 67%). These four species were characterized by NMR spectroscopy, IR spectroscopy, UV–visible spectroscopy, emission spectroscopy, high-resolution mass spectroscopy, cyclic voltammetry, elemental analysis, and single-crystal X-ray diffraction. The presence of an N-oxide functional group red-shifts the emission of the Ir(III) species (Δ 37 nm, 810 cm-1) and has little impact on the emission of the Ru(II) species. Calculated HOMO and LUMO surfaces suggested, and cyclic voltammetry data supported, that the Ir(III) compounds undergo an interligand (L→L') energy transfer involving this N-oxide, and the Ru(II) compounds undergo a metal-to-ligand charge transfer (MLCT) that does not involve the N-oxide.
n -氧化物官能团通常用于医药应用（即显像剂）；然而，它在过渡金属化学中的存在是有限的。为了研究n-氧化物官能团对有机金属配合物性能的影响，合成了含n-氧化物的Ir（III）和Ru（II）杂电性过渡金属配合物及相应的非n-氧化物同族物（产率>； 67%）。通过核磁共振光谱、红外光谱、紫外可见光谱、发射光谱、高分辨率质谱、循环伏安法、元素分析和单晶x射线衍射对这4种物质进行了表征。n -氧化物官能团的存在使Ir（III）的发射红移（Δ 37 nm, 810 cm-1），而对Ru（II）的发射影响不大。计算的HOMO和LUMO表面表明，Ir（III）化合物发生了涉及n -氧化物的配体间（L→L’）能量转移，而Ru（II）化合物发生了不涉及n -氧化物的金属到配体的电荷转移（MLCT）。
{"title":"A comparison of how the N-oxide functional group modulates the properties of a Ru(II) and an Ir(III) complex","authors":"Barbara C. Higgs , Bre-Anna N. Willis , Vinesah A.M. Goodwin , Gaël Ung , Colin D. McMillen , Eloise K. Burick , Jorge Barroso , Jared A. Pienkos","doi":"10.1016/j.jorganchem.2025.123932","DOIUrl":"10.1016/j.jorganchem.2025.123932","url":null,"abstract":"<div><div>The <em>N</em>-oxide functional group is commonly utilized in medicinal applications (i.e., imaging agents); however, its presence in transition metal chemistry is limited. To investigate the impact of an <em>N</em>-oxide functional group on the properties of organometallic complexes, <em>N</em>-oxide-containing Ir(III) and Ru(II) heteroleptic transition metal complexes and corresponding non-<em>N</em>-oxide congeners were synthesized (yields > 67%). These four species were characterized by NMR spectroscopy, IR spectroscopy, UV–visible spectroscopy, emission spectroscopy, high-resolution mass spectroscopy, cyclic voltammetry, elemental analysis, and single-crystal X-ray diffraction. The presence of an <em>N</em>-oxide functional group red-shifts the emission of the Ir(III) species (Δ 37 nm, 810 cm<sup>-1</sup>) and has little impact on the emission of the Ru(II) species. Calculated HOMO and LUMO surfaces suggested, and cyclic voltammetry data supported, that the Ir(III) compounds undergo an interligand (L→L') energy transfer involving this <em>N</em>-oxide, and the Ru(II) compounds undergo a metal-to-ligand charge transfer (MLCT) that does not involve the <em>N</em>-oxide.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123932"},"PeriodicalIF":2.1,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jorganchem.2025.123931
Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. Amin El Sabban
In this inclusive innovation study, we introduced biosynthesis of chitosan-silver nanoparticles (CS-Ag NPs/C. sativus) by using the extract of Crocus sativus, working as a reducing and capping agent. The physical and chemical characteristics of the produced CS-Ag NPs/C. sativus nanocomposite were analyzed using different techniques, such as FE-SEM, Uv-Vis, EDX, TEM, elemental mapping, XRD and ICP-OES. We calculated the size morphology of Ag NPs with diameters in a scope from 20–30 nm by TEM results. A novel and effective direct strategy for producing 5-Phenyl-1H-tetrazoles with good yields has been formulated by apply the fabricated CS-Ag NPs/C. sativus catalyst. The synthesis process incorporated a three-component and one-pot [3 + 2] cycloaddition condensation that included sodium azide, hydroxylamine, and aldehyde, all catalyzed by CS-Ag NPs/C. sativus. The proposed mechanism likely consists of the in situ generation of nitrile as intermediate, which then undergo a [3 + 2] cycloaddition with NaN3. The catalyst demonstrated the capability of being recovered and reused for a minimum of 9 cycles without a significant drop in catalytic efficiency. This approach consists additional benefits for the production of 5-Phenyl-1H-tetrazoles, such as easy access to starting substrates, simple reaction system, straightforward execution, and perfect yields.
{"title":"Bio-fabricated of chitosan capped silver nanoparticles: Its catalytic performance for synthesis of 5-aryl-1H-tetrazoles from aldehydes","authors":"Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. Amin El Sabban","doi":"10.1016/j.jorganchem.2025.123931","DOIUrl":"10.1016/j.jorganchem.2025.123931","url":null,"abstract":"<div><div>In this inclusive innovation study, we introduced biosynthesis of chitosan-silver nanoparticles (CS-Ag NPs/<em>C. sativus</em>) by using the extract of <em>Crocus sativus</em>, working as a reducing and capping agent. The physical and chemical characteristics of the produced CS-Ag NPs/<em>C. sativus</em> nanocomposite were analyzed using different techniques, such as FE-SEM, Uv-Vis, EDX, TEM, elemental mapping, XRD and ICP-OES. We calculated the size morphology of Ag NPs with diameters in a scope from 20–30 nm by TEM results. A novel and effective direct strategy for producing 5-Phenyl-1<em>H</em>-tetrazoles with good yields has been formulated by apply the fabricated CS-Ag NPs/<em>C. sativus</em> catalyst. The synthesis process incorporated a three-component and one-pot [3 + 2] cycloaddition condensation that included sodium azide, hydroxylamine, and aldehyde, all catalyzed by CS-Ag NPs/<em>C. sativus</em>. The proposed mechanism likely consists of the in <em>situ</em> generation of nitrile as intermediate, which then undergo a [3 + 2] cycloaddition with NaN<sub>3</sub>. The catalyst demonstrated the capability of being recovered and reused for a minimum of 9 cycles without a significant drop in catalytic efficiency. This approach consists additional benefits for the production of 5-Phenyl-1<em>H</em>-tetrazoles, such as easy access to starting substrates, simple reaction system, straightforward execution, and perfect yields.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123931"},"PeriodicalIF":2.1,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1016/j.jorganchem.2025.123930
Jing Chen , Yuting Li , Xinyue Wang , Qin Feng , Shenhong Zhang , Ping Yang
One of the most common oral infections that afflict people of all ages globally is dental caries. In order to prevent and treat oral infections as well as other bacterial infections, many medicinal plants and herbal nanoparticles have been used in various medical systems to combat dental caries and other oral infections. These are currently in demand for the development of innovative therapeutic drugs with few side effects. In terms of easy, green, and applicable chemical research, a bio-inspired method for producing copper nanoparticles employing Dendrobium officinalis as a natural reducing and stabilizing agent without the need for hazardous or toxic chemicals is being presented. Cu2O NPs/D. officinalis' capacity to suppress dental bacterial growth and anti-adherence in vitro was investigated in this work. Detailed analysis using methods like TEM, FE-SEM, EDX, ICP-OES, and XRD verified the creation of the Cu2O NPs/D. officinalis nanocomposite. TEM pictures showed spherical nanoparticles with a narrow size distribution, nearing 15–25 nm in dimension. The fabricated Cu2O NPs/D. officinalis showed good activity for N-arylation of imidazole through Ullmann-type C-N coupling. Different aryl halides were transformed into N-arylated imidazoles with good outcomes. Moreover, the Cu2O NPs/D. officinalis could be reused for 7 times with keeping their efficiency. Following that, an investigation was conducted into the biomolecules biological performance that were functionalized Cu2O NPs/D. officinalis. The Cu2O NPs/D. officinalis addition greatly decreased the in vitro adherence of Porphyromonas gingivalis and Streptococcus mutans (MIC = 8 µg/mL). Additionally, P. gingivalis and S. mutans were eliminated by the Cu2O NPs/D. officinalis with an MBC of 8–16 µg/mL. According to the study's findings, Cu2O NPs/D. officinalis could provide an excellent oral hygiene product to prevent dental cavities and periodontal diseases.
{"title":"Green formulation and chemical characterization of copper nanoparticles by Dendrobium officinalis extract: Evaluation of its catalytic activity for Ullmann coupling reaction and determination of the antibacterial activity against oral pathogens","authors":"Jing Chen , Yuting Li , Xinyue Wang , Qin Feng , Shenhong Zhang , Ping Yang","doi":"10.1016/j.jorganchem.2025.123930","DOIUrl":"10.1016/j.jorganchem.2025.123930","url":null,"abstract":"<div><div>One of the most common oral infections that afflict people of all ages globally is dental caries. In order to prevent and treat oral infections as well as other bacterial infections, many medicinal plants and herbal nanoparticles have been used in various medical systems to combat dental caries and other oral infections. These are currently in demand for the development of innovative therapeutic drugs with few side effects. In terms of easy, green, and applicable chemical research, a bio-inspired method for producing copper nanoparticles employing <em>Dendrobium officinalis</em> as a natural reducing and stabilizing agent without the need for hazardous or toxic chemicals is being presented. Cu<sub>2</sub>O NPs/<em>D. officinalis</em>' capacity to suppress dental bacterial growth and anti-adherence in vitro was investigated in this work. Detailed analysis using methods like TEM, FE-SEM, EDX, ICP-OES, and XRD verified the creation of the Cu<sub>2</sub>O NPs/<em>D. officinalis</em> nanocomposite. TEM pictures showed spherical nanoparticles with a narrow size distribution, nearing 15–25 nm in dimension. The fabricated Cu<sub>2</sub>O NPs/<em>D. officinalis</em> showed good activity for <em>N</em>-arylation of imidazole through Ullmann-type C-N coupling. Different aryl halides were transformed into <em>N</em>-arylated imidazoles with good outcomes. Moreover, the Cu<sub>2</sub>O NPs/<em>D. officinalis</em> could be reused for 7 times with keeping their efficiency. Following that, an investigation was conducted into the biomolecules biological performance that were functionalized Cu<sub>2</sub>O NPs/<em>D. officinalis</em>. The Cu<sub>2</sub>O NPs/<em>D. officinalis</em> addition greatly decreased the in vitro adherence of <em>Porphyromonas gingivalis</em> and <em>Streptococcus mutans</em> (MIC = 8 µg/mL). Additionally, <em>P. gingivalis</em> and <em>S. mutans</em> were eliminated by the Cu<sub>2</sub>O NPs/<em>D. officinalis</em> with an MBC of 8–16 µg/mL. According to the study's findings, Cu<sub>2</sub>O NPs/<em>D. officinalis</em> could provide an excellent oral hygiene product to prevent dental cavities and periodontal diseases.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123930"},"PeriodicalIF":2.1,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jorganchem.2025.123929
Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. Amin El Sabban
In this investigation, we used the fruit of Lycium barbarum to develop a natural method for generation of silver nanoparticles (Ag NPs/L. barbarum). The fruit of Lycium barbarum were applied as a green capping, reducing and a stabilizer material to make silver nanoparticles in this process. The produced Ag NPs/L. barbarum has been characterized different techniques like UV–Vis, TEM, FE-SEM, EDX, elemental mapping, and ICP-OES. Further, the catalytic efficiency of this composite has been evaluated in the producing pyrimido[1,2-b]indazole compounds via A3 coupling reaction that involved mixing aryl aldehydes, phenylacetylene and 3-aminoindazoles without using solvent, and it got good yields. After finishing the reaction, the Ag NPs/L. barbarum catalyst could be easily recovered and used again for 7 runs without significant decrease in its efficiency.
在这项研究中，我们利用枸杞的果实，开发了一种自然生成银纳米粒子（Ag NPs/L）的方法。barbarum)。采用枸杞果作为绿色封盖剂、还原剂和稳定剂制备纳米银。产生的Ag NPs/L。利用UV-Vis， TEM, FE-SEM， EDX，元素映射和ICP-OES等技术对barbarum进行了表征。在不使用溶剂的情况下，通过芳醛、苯乙炔和3-氨基茚唑的A3偶联反应，评价了该复合材料的催化效率，并取得了良好的产率。反应结束后，Ag NPs/L。Barbarum催化剂可以很容易地回收，重复使用7次，效率没有明显下降。
{"title":"Phytofabricated of silver nanoparticles (Ag NPs) medated by Lycium barbarum fruit extract: An heteregenous catalyst for solvent-free synthesis of pyrimido[1,2-b]indazoles","authors":"Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. Amin El Sabban","doi":"10.1016/j.jorganchem.2025.123929","DOIUrl":"10.1016/j.jorganchem.2025.123929","url":null,"abstract":"<div><div>In this investigation, we used the fruit of <em>Lycium barbarum</em> to develop a natural method for generation of silver nanoparticles (Ag NPs/L. <em>barbarum</em>). The fruit of <em>Lycium barbarum</em> were applied as a green capping, reducing and a stabilizer material to make silver nanoparticles in this process. The produced Ag NPs/L. <em>barbarum</em> has been characterized different techniques like UV–Vis, TEM, FE-SEM, EDX, elemental mapping, and ICP-OES. Further, the catalytic efficiency of this composite has been evaluated in the producing pyrimido[1,2-b]indazole compounds via A<sup>3</sup> coupling reaction that involved mixing aryl aldehydes, phenylacetylene and 3-aminoindazoles without using solvent, and it got good yields. After finishing the reaction, the Ag NPs/L. <em>barbarum</em> catalyst could be easily recovered and used again for 7 runs without significant decrease in its efficiency.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123929"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.jorganchem.2025.123916
Sara Payamifar, Ahmad Poursattar Marjani
Cellulose-supported metal nanoparticles have emerged as an eco-friendly, sustainable catalyst system for Suzuki reactions, offering an alternative to traditional catalysts. Cellulose, a natural, abundant, biodegradable, and chemically modifiable polymer, serves as an excellent support due to its high thermal stability and abundant hydroxyl groups, which facilitate effective immobilization of metal nanoparticles. The distinctive attributes of metal nanoparticles, including high surface-to-volume ratio, tunable morphology, and enhanced catalytic activity, are further enhanced by cellulose support, resulting in catalysts that are highly active, selective, and easily recoverable. These cellulose-supported catalysts demonstrate excellent functional group tolerance and recyclability, maintaining catalytic efficiency over multiple cycles through simple separation methods such as centrifugation or filtration. Overall, cellulose-supported metal nanoparticles represent a promising class of green heterogeneous catalysts for sustainable organic synthesis with potential industrial applications. This review summarizes key findings from recent research on cellulose-supported metal nanoparticles in Suzuki reactions (covering 2020–2025), emphasizing green, recyclable catalytic systems with high performance and environmental benefits.
{"title":"A review of cellulose-supported metal nanoparticle as a green nanocatalyst in Suzuki reactions","authors":"Sara Payamifar, Ahmad Poursattar Marjani","doi":"10.1016/j.jorganchem.2025.123916","DOIUrl":"10.1016/j.jorganchem.2025.123916","url":null,"abstract":"<div><div>Cellulose-supported metal nanoparticles have emerged as an eco-friendly, sustainable catalyst system for Suzuki reactions, offering an alternative to traditional catalysts. Cellulose, a natural, abundant, biodegradable, and chemically modifiable polymer, serves as an excellent support due to its high thermal stability and abundant hydroxyl groups, which facilitate effective immobilization of metal nanoparticles. The distinctive attributes of metal nanoparticles, including high surface-to-volume ratio, tunable morphology, and enhanced catalytic activity, are further enhanced by cellulose support, resulting in catalysts that are highly active, selective, and easily recoverable. These cellulose-supported catalysts demonstrate excellent functional group tolerance and recyclability, maintaining catalytic efficiency over multiple cycles through simple separation methods such as centrifugation or filtration. Overall, cellulose-supported metal nanoparticles represent a promising class of green heterogeneous catalysts for sustainable organic synthesis with potential industrial applications. This review summarizes key findings from recent research on cellulose-supported metal nanoparticles in Suzuki reactions (covering 2020–2025), emphasizing green, recyclable catalytic systems with high performance and environmental benefits.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1043 ","pages":"Article 123916"},"PeriodicalIF":2.1,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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