Journal of Organometallic Chemistry最新文献_第7页

2-nitroethenyl ferrocene as a photosensitizer: Evaluation of its photodynamic antitumor properties 作为光敏剂的2-硝基乙烯基二茂铁：其光动力抗肿瘤性能的评价

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-19 DOI: 10.1016/j.jorganchem.2025.123952

Huijun Yuan , Min Pei , Baoqing Lv , Dongyu Mei , Yongchang Zhou , Le Wang , Xiuying Pu , Tiankun Zhao

2-Nitroethenyl ferrocene (NVFc) was synthesized in excellent yield via a condensation reaction between ferrocenecarboxaldehyde and nitromethane. The compound was fully characterized using ¹H and ¹³C NMR spectroscopy, UV-Vis spectroscopy, high-resolution mass spectrometry (HRMS), and X-ray crystallography. Under dark conditions, NVFc exhibited negligible cytotoxicity against Hep G2 and HeLa S3 tumor cell lines. However, upon visible light irradiation (400–625 nm) for 10 minutes, its photodynamic cytotoxicity increased markedly. The most pronounced phototoxic effect was observed in HeLa S3 cells under 520 nm light exposure, with an IC₅₀ of 3.52 ± 1.31 μM. For Hep G2 cells, maximal photocytotoxicity occurred under 620 nm irradiation, with an IC₅₀ of 2.81 ± 0.95 μM. Mechanistic investigations revealed that NVFc promotes the generation of reactive oxygen species (ROS), with a singlet oxygen (¹O₂) quantum yield (ΦΔ) of 76.5% in DMSO/PBS (1:199, v/v), which is higher than that of several clinically used organic photosensitizers. NVFc also caused a marked reduction in mitochondrial membrane potential (MMP) in HeLa S3 cells, indicating that mitochondrial dysfunction plays a central role in its cytotoxic activity. In addition, NVFc was found to induce ferroptosis, as evidenced by the downregulation of key ferroptosis-related proteins, GPX4 and SLC7A11.

以二茂铁甲醛与硝基甲烷为原料，通过缩合反应合成了2-亚硝基二茂铁（NVFc）。利用1H和13C NMR、UV-Vis光谱、高分辨率质谱（HRMS）和x射线晶体学对化合物进行了全面表征。在黑暗条件下，NVFc对Hep G2和HeLa S3肿瘤细胞系的细胞毒性可以忽略不计。但在400 ~ 625 nm可见光照射10 min后，其光动力细胞毒性明显增强。在520 nm光照射下，HeLa S3细胞的光毒性作用最为明显，IC50为3.52±1.31 μM。对Hep G2细胞，在620 nm照射下产生最大的光毒性，IC50为2.81±0.95 μM。机理研究表明，NVFc促进活性氧（ROS）的生成，在DMSO/PBS （1:199, v/v）中，单线态氧（1O2）量子产率（ΦΔ）达到76.5%，高于几种临床使用的有机光敏剂。NVFc还导致HeLa S3细胞线粒体膜电位（MMP）显著降低，表明线粒体功能障碍在其细胞毒性活性中起核心作用。此外，研究还发现NVFc可诱导铁下垂，这可以通过下调关键的铁下垂相关蛋白GPX4和SLC7A11来证明。

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引用次数: 0

Magnetically recoverable gold catalyst supported on PVim-Grafted Fe₃O₄@CQD composite for efficient nitroarene reduction in water pvim -接枝Fe₃O₄@CQD复合材料负载磁可回收金催化剂高效还原水中硝基芳烃

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-12 DOI: 10.1016/j.jorganchem.2025.123941

Soheila Ghasemi, Maryam Karimzadeh, Hadieh Rahbar Kafshboran

This work describes the preparation and characterization of a magnetically recoverable gold (Au) catalyst supported on a composite based on poly(N-vinylimidazole) (PVim). Initially, Fe₃O₄ magnetic nanoparticles (MNPs) were fabricated via a co-precipitation process using Fe³⁺ and Fe²⁺ salts. Nitrogen-doped carbon quantum dots (NCQDs), obtained from citric acid as a green and cost-effective precursor, were then introduced to modify the MNPs. The resulting Fe₃O₄@CQD composite was functionalized with vinyltriethylsilane (VTES) to introduce polymerizable moieties, forming Fe₃O₄@CQD@SiO₂. Subsequently, PVim was grafted onto the functionalized surface via radical polymerization using a “grafting from” approach. This functionalized support was employed to stabilize gold species, yielding the final catalyst, Fe₃O₄@CQD@SiO₂@PVim@Au. The composite catalyst exhibited excellent activity in the reduction of various nitroaromatic compounds to their primary amine’s counterparts, even at very low Au loadings in water. Notably, the catalyst can be simply removed using an external magnet and reused for at least nine successive cycles with slight loss of catalytic performance, highlighting its potential for sustainable and practical applications in green chemistry.

本文描述了一种基于聚n -乙烯基咪唑（PVim）复合材料的磁性可回收金（Au）催化剂的制备和表征。最初，用Fe³+和Fe²+盐通过共沉淀法制备了Fe₃O₄磁性纳米颗粒（MNPs）。然后引入从柠檬酸中获得的氮掺杂碳量子点（NCQDs）作为绿色和经济的前驱体来修饰MNPs。得到的Fe₃O₄@ cqd复合材料被乙烯基三乙基硅烷（VTES）功能化以引入可聚合的基团，形成Fe₃O₄@CQD@SiO₂。随后，采用“接枝”方法通过自由基聚合将PVim接枝到功能化表面上。这种功能化载体被用来稳定金，得到最终的催化剂Fe₃O₄@CQD@SiO₂@PVim@Au。该复合催化剂在将各种硝基芳香族化合物还原为伯胺类化合物方面表现出优异的活性，即使在水中的Au含量很低的情况下也是如此。值得注意的是，该催化剂可以使用外部磁铁简单地去除，并且在催化性能略有损失的情况下重复使用至少9个连续循环，突出了其在绿色化学中的可持续和实际应用潜力。

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引用次数: 0

Tetracycline chemosensors: Materials, mechanisms, and applications 四环素化学传感器：材料、机制和应用

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-13 DOI: 10.1016/j.jorganchem.2025.123942

Afroz Gul , Erdal Yabalak , Yahya Nural

Tetracyclines are well known for their diverse applications, including the treatment of various infections, the promotion of growth in poultry and cattle, and their use in animal husbandry. However, extended exposure to these antibiotics can lead to health problems and environmental pollution. This necessitates the development of time-saving and environmentally friendly devices, such as chemosensors, for their effective detection. This review provides a detailed account of the applications of the chemosensors as detection tools for tetracyclines, where metal-organic frameworks, metal coordination polymers and nanomaterials are considered as the main categories of these probes. The review highlights current research on the topic, shedding light on different types of chemosensors and their mechanisms of interaction with tetracyclines. Real-sample applications, test-strip determinations and smartphone-assisted detection methods are also briefly discussed. The review also draws attention to some of the areas where research is required. As the review presents the current state of progress in the detection of tetracyclines using chemosensors, it is hoped that it can be used as a stepping stone for future research.

四环素素以其多种用途而闻名，包括治疗各种感染，促进家禽和牛的生长，以及在畜牧业中的应用。然而，长期接触这些抗生素会导致健康问题和环境污染。这就需要开发节省时间和环保的设备，如化学传感器，以有效地检测它们。本文详细介绍了化学传感器作为四环素类药物检测工具的应用，其中金属有机框架、金属配位聚合物和纳米材料被认为是这些探针的主要类别。综述重点介绍了该主题的当前研究，揭示了不同类型的化学传感器及其与四环素相互作用的机制。还简要讨论了实际样品应用、试纸测定和智能手机辅助检测方法。该审查还提请注意一些需要研究的领域。本文综述了利用化学传感器检测四环素类药物的研究进展，以期为今后的研究奠定基础。

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引用次数: 0

Green synthesis of nickel nanoparticles mediated by Lavandula angustifolia extract: Investigation of its catalytic activity in Suzuki coupling reactions 薰衣草提取物介导的纳米镍绿色合成：铃木偶联反应的催化活性研究

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-18 DOI: 10.1016/j.jorganchem.2025.123953

Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P.R. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , Mustafa Diab , H. Amin El Sabban

Bioinspired creation of mono-dispersed nickel nanoparticles was done using an aqueous flower extract of Lavandula angustifolia. The desired extract acted both as a reducing agent and as a stabilizer for the nanoparticles. Comprehensive characterization via inclusive innovation techniques TEM, FE-SEM, EDX, ICP-OES, and elemental-mapping confirmed the creation of the NiO NPs@L. angustifolia material. TEM revealed spherical nanoparticles with a narrow size distribution, nearing ∼10 nm. The produced NiO NPs@L. angustifolia showed impressive results in the CC cross-coupling Suzuki-Miyaura reaction, yielding high amounts of biaryl compounds. The catalyst illustrated good stability and heterogeneous properties, as verified by hot filtration tests. In addition, the catalyst could be reused for 6 cycles with only a minor decrease in its efficiency for C–C bond formation.

用薰衣草花提取物制备了单分散镍纳米颗粒。所需要的提取物既可以作为还原剂，又可以作为纳米颗粒的稳定剂。通过包容性创新技术TEM， FE-SEM， EDX， ICP-OES和元素映射进行全面表征，确认了NiO NPs@L的创建。angustifolia材料。透射电镜显示球形纳米颗粒具有狭窄的尺寸分布，接近10 nm。生产出来的蔚来NPs@L。angustifolia在CC交叉偶联Suzuki-Miyaura反应中表现出令人印象深刻的结果，产生大量的联芳基化合物。热过滤试验结果表明，该催化剂具有良好的稳定性和多相性能。此外，该催化剂可以重复使用6个循环，而其形成C-C键的效率仅略有下降。

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引用次数: 0

Arylhydrazone–thiazolyne derived Pd–CNN pincer complexes for carbonylative Suzuki coupling, via iron pentacarbonyl as a sustainable CO surrogate 芳酰腙-噻唑啉衍生的Pd-CNN钳形配合物羰基铃木偶联，通过五羰基铁作为可持续的CO替代物

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-20 DOI: 10.1016/j.jorganchem.2025.123954

Alberto Reyes-Deloso , Juan Guillermo Robledo-Ayala , Emir A. Galván-García , Rodolfo Goméz-Balderas , José Guillermo Penieres-Carrillo , Fernando Ortega-Jiménez

We report the efficient synthesis and characterization of novel non-symmetric Pd-CNN pincer complexes via C–H bond activation on arylhydrazone-thioether ligands, which serve as effective catalytic precursors for carbonylative Suzuki coupling reactions. The complexes were synthesized using arylhydrazone-thiazolyne ligands, exhibiting enhanced stability and reactivity under ambient conditions. Their catalytic performance was evaluated using Fe(CO)₅ as a carbon monoxide surrogate, addressing the limitations of traditional methods that often involve toxic CO_(g) sources. Actually, Fe(CO)₅ is considered a more practical CO source compared to gaseous CO due to its safer handling and ability to release CO in a controlled manner under reaction conditions; additionally, it is commercially available, cost-effective, and generates minimal metal waste, offering a more sustainable alternative for carbonylative transformations in synthetic chemistry. The optimized reaction conditions yielded significant product formation, with various aryl and heteroaryl halides successfully coupled to produce biaryl ketones, including an antineoplastic agent. The findings highlight the versatility and efficiency of the synthesized pincer complexes in carbonylative Suzuki coupling, paving the way for safer and more effective synthetic methodologies in organic chemistry. A computational study of the Suzuki carbonylative coupling catalytic cycle, using Fe(CO)₅ as the CO source, revealed low energy barriers for key steps and a favorable overall energy profile (ΔE = –33.96 kcal/mol), supporting the experimental efficiency observed. The evaluation of two alternative mechanistic pathways showed that the initial CO coordination plays a decisive thermodynamic role in determining the preferred route through the catalytic cycle, balancing kinetic accessibility and overall stability. These results are consistent with the suitability of Fe(CO)₅ as an effective CO surrogate in carbonylative cross-coupling reactions.

本文报道了在芳酰腙-硫醚配体上通过C-H键激活高效合成和表征新型非对称Pd-CNN螯合物，该螯合物可作为羰基化铃木偶联反应的有效催化前体。用芳酰腙-噻唑啉配体合成的配合物在环境条件下表现出更高的稳定性和反应活性。使用Fe(CO)5作为一氧化碳替代物来评估它们的催化性能，解决了传统方法通常涉及有毒CO(g)源的局限性。实际上，与气态CO相比，Fe（CO）₅被认为是更实用的CO源，因为它更安全的处理和在反应条件下以受控方式释放CO的能力；此外，它是商业上可用的，具有成本效益，并且产生的金属废物最少，为合成化学中的羰基化转化提供了更可持续的替代方案。优化后的反应条件产生了显著的产物，各种芳基和杂芳基卤化物成功偶联生成了联芳基酮，包括一种抗肿瘤药。研究结果突出了羰基化Suzuki偶联钳形配合物的多功能性和效率，为有机化学中更安全、更有效的合成方法铺平了道路。以Fe(CO)5为CO源的Suzuki羰基化偶联催化循环的计算研究表明，关键步骤的能量势垒较低，总体能量分布较好（ΔE = -33.96 kcal/mol），支持实验观察到的效率。对两种可选机理的评价表明，初始CO配位在确定催化循环的优选途径、平衡动力学可及性和总体稳定性方面起决定性的热力学作用。这些结果与Fe(CO)5作为羰基化交叉偶联反应中有效的CO替代物的适用性相一致。

{"title":"Arylhydrazone–thiazolyne derived Pd–CNN pincer complexes for carbonylative Suzuki coupling, via iron pentacarbonyl as a sustainable CO surrogate","authors":"Alberto Reyes-Deloso , Juan Guillermo Robledo-Ayala , Emir A. Galván-García , Rodolfo Goméz-Balderas , José Guillermo Penieres-Carrillo , Fernando Ortega-Jiménez","doi":"10.1016/j.jorganchem.2025.123954","DOIUrl":"10.1016/j.jorganchem.2025.123954","url":null,"abstract":"<div><div>We report the efficient synthesis and characterization of novel non-symmetric Pd-CNN pincer complexes via C–H bond activation on arylhydrazone-thioether ligands, which serve as effective catalytic precursors for carbonylative Suzuki coupling reactions. The complexes were synthesized using arylhydrazone-thiazolyne ligands, exhibiting enhanced stability and reactivity under ambient conditions. Their catalytic performance was evaluated using Fe(CO)<sub>5</sub> as a carbon monoxide surrogate, addressing the limitations of traditional methods that often involve toxic CO<sub>(g)</sub> sources. Actually, Fe(CO)₅ is considered a more practical CO source compared to gaseous CO due to its safer handling and ability to release CO in a controlled manner under reaction conditions; additionally, it is commercially available, cost-effective, and generates minimal metal waste, offering a more sustainable alternative for carbonylative transformations in synthetic chemistry. The optimized reaction conditions yielded significant product formation, with various aryl and heteroaryl halides successfully coupled to produce biaryl ketones, including an antineoplastic agent. The findings highlight the versatility and efficiency of the synthesized pincer complexes in carbonylative Suzuki coupling, paving the way for safer and more effective synthetic methodologies in organic chemistry. A computational study of the Suzuki carbonylative coupling catalytic cycle, using Fe(CO)<sub>5</sub> as the CO source, revealed low energy barriers for key steps and a favorable overall energy profile (ΔE = –33.96 kcal/mol), supporting the experimental efficiency observed. The evaluation of two alternative mechanistic pathways showed that the initial CO coordination plays a decisive thermodynamic role in determining the preferred route through the catalytic cycle, balancing kinetic accessibility and overall stability. These results are consistent with the suitability of Fe(CO)<sub>5</sub> as an effective CO surrogate in carbonylative cross-coupling reactions.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123954"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid photocatalytic system: Penta-methylcyclopentadienyl-rhodium-bipyridine complex and sulfur-bridged TBA polymer for enhanced cofactor regeneration and solar-driven chemical synthesis 杂化光催化系统：五甲基环戊二烯-铑-联吡啶配合物和硫桥TBA聚合物用于增强辅助因子再生和太阳能驱动的化学合成

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-19 DOI: 10.1016/j.jorganchem.2025.123944

Ashutosh Mishra , Rehana Shahin , Kanchan Sharma , Shaifali Mishra , Satyanath , Rajesh Kumar Yadav , Navneet K. Gupta , Jin OoK Baeg

The development of efficient photocatalytic materials is crucial for advancing renewable energy technologies and sustainable energy conversion. In this study, we report the design and synthesis of a sulfur-bridged 2,4,6-tribromoaniline (TBA@S) polymeric composite photocatalyst for solar-driven chemical synthesis and selective regeneration of nicotinamide adenine dinucleotide (NADH) cofactors. NADH is central to numerous biochemical reactions, including cellular energy production, making its efficient regeneration highly desirable for bio-inspired catalytic processes. The TBA framework was selected for its robust stability under reaction conditions, while the introduction of sulfur bridges provides electron-rich centers that facilitate charge transfer and enhance light-driven catalytic efficiency. These features collectively improve the photocatalytic activity of TBA@S. The photocatalyst achieved selective NADH regeneration (60.02%) via a penta-methylcyclopentadienyl-rhodium-bipyridine complex ([Cp*Rh(bpy)(H₂O)]²⁺), along with solar chemical synthesis of a Biginelli product (81%) under solar irradiation. Overall, the newly developed TBA@S polymer composite demonstrates strong potential for cofactor regeneration and solar fine chemical production, highlighting its relevance for sustainable catalytic applications.

高效光催化材料的开发是推进可再生能源技术和可持续能源转化的关键。在这项研究中，我们设计和合成了一种硫桥式2,4,6-三溴苯胺（TBA@S）聚合物复合光催化剂，用于烟酰胺腺嘌呤二核苷酸（NADH）辅助因子的太阳能化学合成和选择性再生。NADH是许多生物化学反应的核心，包括细胞能量生产，使其高效再生成为生物激发催化过程的理想选择。选择TBA框架是因为它在反应条件下具有强大的稳定性，而硫桥的引入提供了富电子中心，促进电荷转移并提高了光驱动催化效率。这些特性共同提高了TBA@S的光催化活性。该光催化剂通过五甲基环pentadienyl-铑-联吡啶配合物([Cp*Rh（bpy)(H₂O)] 2 +）实现了选择性NADH再生（60.02%），同时在太阳照射下太阳能化学合成了Biginelli产物（81%）。总体而言，新开发的TBA@S聚合物复合材料显示了辅助因子再生和太阳能精细化工生产的强大潜力，突出了其与可持续催化应用的相关性。

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引用次数: 0

Metal and metal-free catalyst “click” synthesis mechanism of triazole from acetylene and azide- review 金属及无金属催化剂乙炔与叠氮化物“咔嗒”合成三唑机理综述

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-12 DOI: 10.1016/j.jorganchem.2025.123940

Jayasri Rangasamy, Kavinkumar Ravikumar, Udhayakeerthana Manimaran, Rutika Yogesh Bundela, Milind Shrinivas Dangate

Recently, organic synthesis has advanced significantly thanks in large part to the triazole compound. 1,2,3-Triazoles are fundamental aromatic heterocyclic scaffolds. The Huisgen cycloaddition of azide and alkyne, which involves a 1,3-dipolar cycloaddition reaction between the two, may be used to produce substituted 1,2,3-triazoles. Its structural nature makes this moiety valuable in material science as well. Numerous manufactured and naturally occurring chemicals that are significant to biology include these repetitive patterns. Developing efficient synthesis techniques is crucial for drug discovery. The ability to substitute new functionalized triazole for the azide and acetylene groups in an existing amide is made possible via click chemistry, a widely used technique in organic and medicinal chemistry. The click reaction has been considerably accelerated using metal catalysis; however, the same reaction has also been performed using several solvent-free, metal-free, and catalysis-free methods. The utilization of organic compounds and solvents is highlighted in this study, which focuses on recent research on metal-free-catalysed Click reactions. The roles of catalysts in improving reaction efficiency both catalytic and stoichiometric quantities are reviewed.

最近，有机合成在很大程度上由于三唑化合物而取得了显著的进步。1,2,3-三唑类化合物是芳香杂环类化合物的基本支架。叠氮化物与炔的Huisgen环加成反应涉及两者之间的1,3-偶极环加成反应，可用于生产取代的1,2,3-三唑。它的结构性质使得这部分在材料科学中也很有价值。许多人造的和自然发生的化学物质对生物学有重要意义，包括这些重复的模式。开发高效的合成技术对药物发现至关重要。通过点击化学，一种广泛应用于有机化学和药物化学的技术，可以将新的功能化三唑取代现有酰胺中的叠氮化物和乙炔基团。在金属催化作用下，咔嗒反应被大大加速；然而，同样的反应也可以用几种无溶剂、无金属和无催化剂的方法进行。本文重点介绍了近年来无金属催化咔嗒反应的研究进展，重点介绍了有机化合物和溶剂的应用。综述了催化剂在提高反应效率和化学计量量方面的作用。

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引用次数: 0

Green synthesis of silver nanoparticles as an efficient catalyst for one-pot preparation of pyrano[2,3-d]pyrimidines 绿色合成纳米银作为一锅法制备吡喃[2,3-d]嘧啶的高效催化剂

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-21 DOI: 10.1016/j.jorganchem.2025.123957

Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. El Sabban

In this inclusive innovation research, we have successfully synthesized mono-dispersed silver nanoparticles mediated by Pistacia leaves extract as reducing and stabilizing agent. The reduction in Ag⁺ ions to Ag⁰ nanoparticles was visually proved by a change in color from green to gray color. The present study employs numerous analytical methods like UV–Vis, FT-IR, TEM, SEM, EDX, ICP-OES, elemental mapping, XRD to identify the characteristics of the Ag NPs/Pistacia nanocomposite. TEM analysis revealed the spherical shapes of nanoparticles that have sizes of around 20–30 nm. Due to Importance of pyrano[2,3-d]pyrimidines in pharmaceutical science and their pharmacological activities, we interested to apply Ag NPs/Pistacia as efficient catalyst in the production of pyrano[2,3-d]pyrimidines via a three-component condensation that included barbituric acid, aryl aldehydes, and malononitrile. Furthermore, the Ag NPs/Pistacia catalyst demonstrated commendable recyclability, sustaining its catalytic efficacy after being utilized 7 times with minimal reduction in performance. Easy separation of products, purification without need to column chromatographic, and use of commercially available low-cost substrates make the protocol viable in organic synthesis.

在这项包容性创新研究中，我们成功合成了以黄连木叶提取物为还原剂和稳定剂的单分散纳米银。Ag+离子还原成Ag0纳米粒子，颜色从绿色变为灰色，从视觉上证明了这一点。本研究采用UV-Vis、FT-IR、TEM、SEM、EDX、ICP-OES、元素图谱、XRD等多种分析方法对银纳米颗粒/黄连木纳米复合材料进行了表征。透射电镜分析显示，纳米颗粒的大小约为20-30纳米。鉴于吡喃[2,3-d]嘧啶在制药科学中的重要性及其药理活性，我们有意将Ag NPs/Pistacia作为高效催化剂，通过包括巴比妥酸、芳醛和丙二腈的三组分缩合反应生产吡喃[2,3-d]嘧啶。此外，Ag NPs/Pistacia催化剂表现出值得称赞的可回收性，在使用7次后仍保持其催化效果，性能下降最小。产品易于分离，无需柱层析纯化，以及使用市售的低成本底物，使该方案在有机合成中可行。

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引用次数: 0

Dual anti-inflammatory and antidiabetic potential of ferrocenylmethylcyanophenyl derivatives: Integrated In Vitro and In Silico evaluation 二茂铁甲基氰苯基衍生物的双重抗炎和降糖潜力：体外和计算机综合评价

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-15 Epub Date: 2025-11-20 DOI: 10.1016/j.jorganchem.2025.123956

Touhami Lanez, Meriem Henni

This study reports the systematic evaluation of ferrocenylmethylcyanophenyl (FcCN) and ferrocenylmethylcyanophenylacetamide (FcCNCO) derivatives as dual anti-inflammatory and antidiabetic agents. The FcCN derivatives were synthesized via nucleophilic substitution of aminobenzonitrile on methylenic carbons adjacent to quaternary ammonium centers, followed by acylation with acetic anhydride to yield the corresponding FcCNCO derivatives. These well-established reactions constitute a reliable and reproducible synthetic framework for the preparation of the target compounds. In vitro assays demonstrated that Fc2CNCO exhibited superior anti-inflammatory activity (IC₅₀ = 4.17 µM) compared to diclofenac (IC₅₀= 6.40 µM), while Fc4CNCO strongly inhibited α-amylase (IC₅₀ = 1.15 µM), approaching the potency of acarbose (IC₅₀= 0.33 µM). Molecular docking and 100 ns molecular dynamics simulations confirmed stable protein–ligand interactions, consistent with the experimental results, and highlighted the key roles of hydrogen bonding, hydrophobic contacts, and π–stacking in driving selectivity. Structure–activity relationship analysis revealed substitution-dependent trends: ortho-acetamide substitution enhanced anti-inflammatory potency, whereas para-substitution favored α-amylase inhibition. These findings establish ferrocenyl scaffolds as promising multifunctional drug leads and provide rational design principles for future agents targeting comorbid inflammatory and metabolic disorders.

本研究报道了二茂铁甲基氰苯（FcCN）和二茂铁甲基氰苯乙酰胺（FcCNCO）衍生物作为抗炎和降糖双重药物的系统评价。通过将氨基苯腈亲核取代邻近季铵中心的亚甲基碳，再与乙酸酐酰化，合成FcCNCO衍生物。这些已建立的反应为目标化合物的制备提供了可靠和可重复的合成框架。体外实验表明，与双氯芬酸（IC50= 6.40µM）相比，Fc2CNCO具有更强的抗炎活性（IC50= 4.17µM），而Fc4CNCO对α-淀粉酶的抑制作用（IC50= 1.15µM）接近阿卡波糖（IC50= 0.33µM）。分子对接和100 ns分子动力学模拟证实了稳定的蛋白质-配体相互作用，与实验结果一致，并强调了氢键、疏水接触和π堆积在驱动选择性中的关键作用。构效关系分析显示取代依赖性趋势：正乙酰胺取代增强抗炎效力，而对乙酰胺取代有利于α-淀粉酶抑制。这些发现确立了二茂铁支架作为有前途的多功能药物先导物，并为未来针对共病炎症和代谢紊乱的药物提供了合理的设计原则。

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引用次数: 0

Recyclable and reusable AuBr3/PEG-400/H2O system for highly efficient three-component coupling of aldehydes, alkynes, and amines 可回收和可重复使用的AuBr3/PEG-400/H2O体系，用于醛、炔和胺的高效三组分偶联

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry

Pub Date : 2026-01-01 Epub Date: 2025-10-23 DOI: 10.1016/j.jorganchem.2025.123908

Xiao Chen, Jiatao Zhang, Mingzhong Cai

AuBr₃ in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the three-component coupling of aldehydes, alkynes, and amines via C‒H activation of alkynes. In the presence of 1 mol% of AuBr₃, the reaction proceeds smoothly in PEG-400/H₂O (1:1) at 100 °C, generating a variety of propargylamines in 57–96% yields along with water as the only byproduct. The isolation of the products is easily performed by the extraction with cyclohexane and more importantly, expensive AuBr₃ in PEG-400/H₂O system could be readily recycled and reused at least six times without any significant loss of catalytic efficiency. Compared with recyclable metal-catalyzed A³-coupling, the easy product isolation, the AuBr₃/PEG-400/H₂O system recycling, and avoiding the preparation of supported metal catalysts, which requires a complex multi-step procedure, are important advantages of the developed methodology.

在聚乙二醇（PEG-400）和水的混合物中，AuBr3是一种高效的催化剂，通过C-H活化炔烃，实现醛、炔和胺的三组分偶联。当AuBr3浓度为1mol %时，在PEG-400/H2O（1:1）条件下，反应在100℃下顺利进行，生成多种丙胺，产率为57-96%，唯一的副产物是水。更重要的是，昂贵的AuBr3在PEG-400/H2O体系中可以很容易地回收和重复使用至少6次，而没有明显的催化效率损失。与可回收金属催化的a3偶联相比，该方法具有易于产物分离、AuBr3/PEG-400/H2O体系可循环利用、避免制备负载型金属催化剂等重要优点。

引用次数: 0