Pub Date : 2025-03-20DOI: 10.1016/j.jorganchem.2025.123623
Gehad E. Said , Mahmoud Tarek , Abdulrahman A. Almehizia , Ahmed M. Naglah , Hazem A. Ghabbour , Tamer K. Khatab
Nicotinic acid was presented as MOF-mediated in the hydrothermal synthesis of silver MOF nanoparticles followed by the crystallography study of its structure by IR, SEM, TEM, and XRD. The catalytic properties of the prepared Ag/NA-MOF were achieved in the synthesis of some new tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1(2H)-one derivatives through one pot mixing of dimedone, 2-aminobenzimidazole and aromatic aldehyde in the presence of catalytic amount of Ag/NA-MOF under solvent-free conditions. The synthesized tetracyclic imidazoquinazoline derivatives were binding ligands with acetylcholine esterase (AChE inhibitors). The in vitro validation approved the theoretical data through colorimetric determination of acetylcholinesterase activity. The data obtained explained that the compounds 4c, 4f, 4i and 4j give promising values and the most potent one is 4i by IC50 value of 5.93 ± 0.02 μg/mL compared to the standard donepezil value of 5.18 ± 0.02 μg/mL as a reference Alzheimer's drug.
{"title":"Solvothermal Synthesis of Innovative and Efficient Ag/NA-MOF Nanoparticles for One-Pot Synthesis of Imidazoquinazolinones and In vitro Validation as Anti-Alzheimer Agents","authors":"Gehad E. Said , Mahmoud Tarek , Abdulrahman A. Almehizia , Ahmed M. Naglah , Hazem A. Ghabbour , Tamer K. Khatab","doi":"10.1016/j.jorganchem.2025.123623","DOIUrl":"10.1016/j.jorganchem.2025.123623","url":null,"abstract":"<div><div>Nicotinic acid was presented as MOF-mediated in the hydrothermal synthesis of silver MOF nanoparticles followed by the crystallography study of its structure by IR, SEM, TEM, and XRD. The catalytic properties of the prepared Ag/NA-MOF were achieved in the synthesis of some new tetrahydrobenzo[4,5]imidazo[2,1-<em>b</em>]quinazolin-1(2<em>H</em>)-one derivatives through one pot mixing of dimedone, 2-aminobenzimidazole and aromatic aldehyde in the presence of catalytic amount of Ag/NA-MOF under solvent-free conditions. The synthesized tetracyclic imidazoquinazoline derivatives were binding ligands with acetylcholine esterase (AChE inhibitors). The <em>in vitro</em> validation approved the theoretical data through colorimetric determination of acetylcholinesterase activity. The data obtained explained that the compounds <strong>4c, 4f, 4i</strong> and <strong>4j</strong> give promising values and the most potent one is <strong>4i</strong> by IC<sub>50</sub> value of <strong>5.93 ± 0.02 μg/mL</strong> compared to the standard donepezil value of <strong>5.18 ± 0.02 μg/mL</strong> as a reference Alzheimer's drug.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123623"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-20DOI: 10.1016/j.jorganchem.2025.123634
Kouki Matsubara, Kaichi Ikuta, Shoko Koga, Yuji Koga
A series of Mn(I) and Mn(II) complexes was synthesized from a three-coordinate phenoxyimine ligand with hemilabile pendant groups and readily available manganese salts. Under pyrolytic conditions, Mn(I) carbonyl complexes decomposed in the presence of 2e-donor ligands into Mn(II) and other complexes via disproportionation reactions. Mn(II) complexes exhibited catalytic activity in hydrosilylation of aldehydes and acetophenone. Hydrosilylation proceeded with phenylsilane and water accelerated the catalytic reaction in a system similar to that previously reported for Co(II) analog.
{"title":"Manganese Phenoxyimine complexes: Structures, reactions, and water-assisted hydrosilylation of aldehydes","authors":"Kouki Matsubara, Kaichi Ikuta, Shoko Koga, Yuji Koga","doi":"10.1016/j.jorganchem.2025.123634","DOIUrl":"10.1016/j.jorganchem.2025.123634","url":null,"abstract":"<div><div>A series of Mn(I) and Mn(II) complexes was synthesized from a three-coordinate phenoxyimine ligand with hemilabile pendant groups and readily available manganese salts. Under pyrolytic conditions, Mn(I) carbonyl complexes decomposed in the presence of 2e-donor ligands into Mn(II) and other complexes via disproportionation reactions. Mn(II) complexes exhibited catalytic activity in hydrosilylation of aldehydes and acetophenone. Hydrosilylation proceeded with phenylsilane and water accelerated the catalytic reaction in a system similar to that previously reported for Co(II) analog.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123634"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jorganchem.2025.123626
Eslam A. Mohamed , Amal A. Altalhi , Hend M. Ahmed , Nabel A. Negm
Three photo-stabilizers were prepared and designed from a complexation reaction of (2E)-2-(4-((E)-(2-hydroxyphenylimino)methyl)benzylideneamino)phenol Schiff base and three metal ions: Fe(III), Cu(II), and Ni(II). Their chemical structures were elucidated using elemental analysis, FTIR, 1HNMR, and UV/Vis spectroscopy. The photo-stabilizers were formulated at 0.5 % in PVC sheets and tested under ultraviolet light for 0–250 h. The degradation indexes including unsaturation (ICC), carbonyl (ICO), and hydroxyl (IOH) indexes of pure PVC were 0.12, 0.2, and 0.23. While, the index values were decreased moderately in the case of Cu-stabilizer to 0.025, 0.112, and 0.122, respectively. In the case of the Ni-stabilizer, the degradation indexes considerably reduced to 0.062, 0.078, and 0.110 respectively. The average molecular weight of PVC after 200 h of photo-irradiation was decreased by 80 % in the case of pure PVC, while in the case of stabilized PVC by the prepared photo-stabilizers were 69 %, 56 %, and 39 % for PVC-Fe, PVCCu, and PVCNi, respectively. The photo-stabilizing tendencies of the prepared photo-stabilizers were ascribed based on their ability for radical scavenging and were associated with their antioxidant efficiencies. The antioxidant efficiencies of the synthesized photo-stabilizers were measured and compared to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) as standards. Copper and nickel complexes exhibited higher efficiency than ferric complexes during the photo-stabilization of PVC under the studied conditions. The role of the synthesized photo-stabilizers in the photo-stabilization mechanism was explained.
{"title":"Synergistic effects and comprehensive analysis of photodegradability inhibition of PVC plastics film by novel Schiff base metal complex additives: Performance and Dechlorination mechanism","authors":"Eslam A. Mohamed , Amal A. Altalhi , Hend M. Ahmed , Nabel A. Negm","doi":"10.1016/j.jorganchem.2025.123626","DOIUrl":"10.1016/j.jorganchem.2025.123626","url":null,"abstract":"<div><div>Three photo-stabilizers were prepared and designed from a complexation reaction of (2E)-2-(4-((E)-(2-hydroxyphenylimino)methyl)benzylideneamino)phenol Schiff base and three metal ions: Fe(III), Cu(II), and Ni(II). Their chemical structures were elucidated using elemental analysis, FTIR, <sup>1H</sup>NMR, and UV/Vis spectroscopy. The photo-stabilizers were formulated at 0.5 % in PVC sheets and tested under ultraviolet light for 0–250 h. The degradation indexes including unsaturation (I<sub>C</sub><sub><img></sub><sub>C</sub>), carbonyl (I<sub>C</sub><sub><img></sub><sub>O</sub>), and hydroxyl (I<sub>OH</sub>) indexes of pure PVC were 0.12, 0.2, and 0.23. While, the index values were decreased moderately in the case of Cu-stabilizer to 0.025, 0.112, and 0.122, respectively. In the case of the Ni-stabilizer, the degradation indexes considerably reduced to 0.062, 0.078, and 0.110 respectively. The average molecular weight of PVC after 200 h of photo-irradiation was decreased by 80 % in the case of pure PVC, while in the case of stabilized PVC by the prepared photo-stabilizers were 69 %, 56 %, and 39 % for PVC-Fe, PVC<img>Cu, and PVC<img>Ni, respectively. The photo-stabilizing tendencies of the prepared photo-stabilizers were ascribed based on their ability for radical scavenging and were associated with their antioxidant efficiencies. The antioxidant efficiencies of the synthesized photo-stabilizers were measured and compared to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS<sup>+</sup>) as standards. Copper and nickel complexes exhibited higher efficiency than ferric complexes during the photo-stabilization of PVC under the studied conditions. The role of the synthesized photo-stabilizers in the photo-stabilization mechanism was explained.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123626"},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-14DOI: 10.1016/j.jorganchem.2025.123624
Ghulam Abbas Ashraf , Sulaiman Al-Sulaimi , Noor Hassan , Zeeshan Ajmal , Sajid Mahmood , Raqiqa Tur Rasool , Muhammad Tuoqeer Anwar , Naveed Husnain , Nouf H. Alotaibi , Hanadi Yaqob Alsoqair
Various activation mechanisms have been developed for peroxymonosulfate (PMS), an oxidant that is extensively employed in sulfate radical-based advanced oxidation processes for the elimination of organic contaminants from water. Visible-light-assisted PMS activation presents significant potential for pollution remediation. This study generated Carbon@ZnCuFeS nanoparticles (NPs) via hydrothermal processing and employed them to activate PMS under visible light, resulting in effective pollutant degradation. NPs enabled a synergistic interaction between photocatalysis and PMS activation, with the NPs/Light/PMS combination exhibiting efficacy across a broad pH spectrum, especially in neutral and slightly acidic environments. The reaction rate follows a pseudo-first-order (PFO) kinetic model, with rate constants (0.1056 min−1) varying across systems, highlighting the superior efficiency of the light/NPs/PMS system in accelerating RhB degradation (95.8 %). The radical quenching tests identified SO4•‒ and •OH as reactive species, with h⁺, 1O2, and •O2− as the primary contributors to pollutant degradation. The •O2− produced further activated PMS, generating more •OH via interactions involving SO4•‒ and H2O/OH−. RhB degradation is most efficient at neutral pH, with modest decreases in acidic settings due to H⁺ interference and considerable drops in alkaline surroundings due to charge repulsion and PMS deactivation. The system demonstrated remarkable reusability; nevertheless, degradation efficiency and reaction speeds diminished at elevated RhB concentrations. The efficacy of the NPs/Light/PMS system was assessed across several water types and contaminants, yielding significant insights into the mechanics of visible-light-assisted PMS activation and endorsing an environmentally sustainable approach for the degradation of organic pollutants.
{"title":"Mesoporous Carbon@ZnCuFeS nanoparticles for photocatalytic degradation of organic pollutants via peroxymonosulfate activation","authors":"Ghulam Abbas Ashraf , Sulaiman Al-Sulaimi , Noor Hassan , Zeeshan Ajmal , Sajid Mahmood , Raqiqa Tur Rasool , Muhammad Tuoqeer Anwar , Naveed Husnain , Nouf H. Alotaibi , Hanadi Yaqob Alsoqair","doi":"10.1016/j.jorganchem.2025.123624","DOIUrl":"10.1016/j.jorganchem.2025.123624","url":null,"abstract":"<div><div>Various activation mechanisms have been developed for peroxymonosulfate (PMS), an oxidant that is extensively employed in sulfate radical-based advanced oxidation processes for the elimination of organic contaminants from water. Visible-light-assisted PMS activation presents significant potential for pollution remediation. This study generated Carbon@ZnCuFeS nanoparticles (NPs) via hydrothermal processing and employed them to activate PMS under visible light, resulting in effective pollutant degradation. NPs enabled a synergistic interaction between photocatalysis and PMS activation, with the NPs/Light/PMS combination exhibiting efficacy across a broad pH spectrum, especially in neutral and slightly acidic environments. The reaction rate follows a pseudo-first-order (PFO) kinetic model, with rate constants (0.1056 min<sup>−1</sup>) varying across systems, highlighting the superior efficiency of the light/NPs/PMS system in accelerating RhB degradation (95.8 %). The radical quenching tests identified SO<sub>4</sub><sup>•</sup><sup>‒</sup> and <sup>•</sup>OH as reactive species, with h<sup>⁺</sup>, <sup>1</sup>O<sub>2</sub>, and <sup>•</sup>O<sub>2</sub><sup>−</sup> as the primary contributors to pollutant degradation. The <sup>•</sup>O<sub>2</sub><sup>−</sup> produced further activated PMS, generating more <sup>•</sup>OH via interactions involving SO<sub>4</sub><sup>•</sup><sup>‒</sup> and H<sub>2</sub>O/OH<sup>−</sup>. RhB degradation is most efficient at neutral pH, with modest decreases in acidic settings due to H<sup>⁺</sup> interference and considerable drops in alkaline surroundings due to charge repulsion and PMS deactivation. The system demonstrated remarkable reusability; nevertheless, degradation efficiency and reaction speeds diminished at elevated RhB concentrations. The efficacy of the NPs/Light/PMS system was assessed across several water types and contaminants, yielding significant insights into the mechanics of visible-light-assisted PMS activation and endorsing an environmentally sustainable approach for the degradation of organic pollutants.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123624"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-13DOI: 10.1016/j.jorganchem.2025.123621
Meng-han Li , Feng Zhang , Bao-Han Shan , Yue Zhao , Jia-Xing Lu , Huan Wang
The electrocarboxylation of organic molecules with CO2 allows the synthesis of important carboxylic acids under mild conditions. The introduction of chiral sources enables the catalytic asymmetric synthesis of chiral carboxylic acids using CO2 as a C1 source, which has important application prospects. In this work, we have successfully prepared chiral immobilized electrode materials by encapsulating chiral CoII(R,R)(salen) (CoIIL) complexes in the pores of mesocellular foam (MCF) materials using the strategy of silanization to reduce the pore size. The prepared CoIIL@MCF composites exhibited good electrocatalytic performance in the asymmetric electrocarboxylation of 1-phenylethyl chloride with CO2, leading to the synthesis of chiral 2-phenylpropionic acid with an enantiomeric excess value of 71% and a yield of 49%. The encapsulated CoIIL@MCF composites can significantly reduce the amount of chiral CoIIL complexes used. Moreover, they are stable, easy to separate, and have excellent reusability.
{"title":"Encapsulation of chiral CoII(R,R)(salen) in mesocellular foam as an efficient heterogeneous catalyst for asymmetric electrocarboxylation of 1-phenylethyl chloride with CO2","authors":"Meng-han Li , Feng Zhang , Bao-Han Shan , Yue Zhao , Jia-Xing Lu , Huan Wang","doi":"10.1016/j.jorganchem.2025.123621","DOIUrl":"10.1016/j.jorganchem.2025.123621","url":null,"abstract":"<div><div>The electrocarboxylation of organic molecules with CO<sub>2</sub> allows the synthesis of important carboxylic acids under mild conditions. The introduction of chiral sources enables the catalytic asymmetric synthesis of chiral carboxylic acids using CO<sub>2</sub> as a C1 source, which has important application prospects. In this work, we have successfully prepared chiral immobilized electrode materials by encapsulating chiral Co<sup>II</sup>(R,R)(salen) (Co<sup>II</sup>L) complexes in the pores of mesocellular foam (MCF) materials using the strategy of silanization to reduce the pore size. The prepared Co<sup>II</sup>L@MCF composites exhibited good electrocatalytic performance in the asymmetric electrocarboxylation of 1-phenylethyl chloride with CO<sub>2</sub>, leading to the synthesis of chiral 2-phenylpropionic acid with an enantiomeric excess value of 71% and a yield of 49%. The encapsulated Co<sup>II</sup>L@MCF composites can significantly reduce the amount of chiral Co<sup>II</sup>L complexes used. Moreover, they are stable, easy to separate, and have excellent reusability.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123621"},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-12DOI: 10.1016/j.jorganchem.2025.123617
Jianhui Peng , Siwei Luo , Yisui Cen , Hailiang Li , DeQin Zeng , Can Cai
In this research, we present a green method for synthesizing silver nanoparticles supported on tannic acid (TA)-coated magnetic Fe3O4 nanoparticles (Fe3O4@TA). This nanocomposite functions as both reducing and stabilizing reagent. We specified the constructional and physicochemical features of the synthesized Fe3O4@TA/Ag NPs using several analytical tools, especially TEM, FE-SEM, EDX, elemental mapping, ICP, VSM, and XRD. For catalytic testing, we explored a 1-substituted-tetrazoles synthesis through a multicomponent reaction involving amines, triethyl orthoformate, and sodium azide in solvent-free circumstances, achieving good results. We also corroborated the catalyst stability by reusability tests across six cycles, along with hot filtration and leaching experiments. The in vivo investigation involves evaluating the P. aeruginosa lethal dose in Swiss albino mice, along with a disease manifestations analysis. This analysis includes monitoring reductions in bacteremia, body weight, hypothermia, and various other parameters throughout a 48-hour infection period. The untreated animals demonstrated a significant decline in body temperature, recorded at 25 °C after 48 h, in contrast to the initial measurement of 39 °C. Furthermore, a weight reduction of 30 % was observed by the study end. The evaluation of the efficacy of Fe3O4@TA/Ag NPs nanocomposite in treating lung infections was conducted through the use of calculated lethal doses, bacteremia assessments, and histopathological analyses. On day 8, the bacterial load in the Fe3O4@TA/Ag NPs nanocomposite group was recorded at 0.5 Log10CFU/mL, reflecting a significant reduction from the initial level of 1.5 Log10CFU/mL observed on day 1. The histopathological analysis demonstrated a pervasive and intermittent accumulation of inflammatory cells within the alveolar spaces, with infiltrates detected across all lung sections in the untreated animals. The group of animals that received treatment exhibited improved lung histology, characterized by a decrease in exudates at a dosage of 200 µg/kg. The research clearly establishes the effectiveness of Fe3O4@TA/Ag NPs nanocomposite in addressing lung infections caused by P. aeruginosa at a dosage of 200 µg/kg. This investigation seeks to examine the biomedical properties of these Fe3O4@TA/Ag NPs nanocomposite to formulate a robust treatment for this formidable pathogen.
{"title":"Magnetic Fe3O4 nanoparticles modified with tannic acid as a support for silver nanoparticles: Catalytic efficiency in procuring 1-substituted-1H-tetrazoles and investigation its therapeutic effects on mycoplasma pneumonia infected pneumonia mice model","authors":"Jianhui Peng , Siwei Luo , Yisui Cen , Hailiang Li , DeQin Zeng , Can Cai","doi":"10.1016/j.jorganchem.2025.123617","DOIUrl":"10.1016/j.jorganchem.2025.123617","url":null,"abstract":"<div><div>In this research, we present a green method for synthesizing silver nanoparticles supported on tannic acid (TA)-coated magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@TA). This nanocomposite functions as both reducing and stabilizing reagent. We specified the constructional and physicochemical features of the synthesized Fe<sub>3</sub>O<sub>4</sub>@TA/Ag NPs using several analytical tools, especially TEM, FE-SEM, EDX, elemental mapping, ICP, VSM, and XRD. For catalytic testing, we explored a 1-substituted-tetrazoles synthesis through a multicomponent reaction involving amines, triethyl orthoformate, and sodium azide in solvent-free circumstances, achieving good results. We also corroborated the catalyst stability by reusability tests across six cycles, along with hot filtration and leaching experiments. The in vivo investigation involves evaluating the <em>P. aeruginosa</em> lethal dose in Swiss albino mice, along with a disease manifestations analysis. This analysis includes monitoring reductions in bacteremia, body weight, hypothermia, and various other parameters throughout a 48-hour infection period. The untreated animals demonstrated a significant decline in body temperature, recorded at 25 °C after 48 h, in contrast to the initial measurement of 39 °C. Furthermore, a weight reduction of 30 % was observed by the study end. The evaluation of the efficacy of Fe<sub>3</sub>O<sub>4</sub>@TA/Ag NPs nanocomposite in treating lung infections was conducted through the use of calculated lethal doses, bacteremia assessments, and histopathological analyses. On day 8, the bacterial load in the Fe<sub>3</sub>O<sub>4</sub>@TA/Ag NPs nanocomposite group was recorded at 0.5 Log10CFU/mL, reflecting a significant reduction from the initial level of 1.5 Log10CFU/mL observed on day 1. The histopathological analysis demonstrated a pervasive and intermittent accumulation of inflammatory cells within the alveolar spaces, with infiltrates detected across all lung sections in the untreated animals. The group of animals that received treatment exhibited improved lung histology, characterized by a decrease in exudates at a dosage of 200 µg/kg. The research clearly establishes the effectiveness of Fe<sub>3</sub>O<sub>4</sub>@TA/Ag NPs nanocomposite in addressing lung infections caused by <em>P. aeruginosa</em> at a dosage of 200 µg/kg. This investigation seeks to examine the biomedical properties of these Fe<sub>3</sub>O<sub>4</sub>@TA/Ag NPs nanocomposite to formulate a robust treatment for this formidable pathogen.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123617"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1016/j.jorganchem.2025.123616
Xin Yang , Hongrun Wu , Zaibo Wen
In this work, we present a green and environmentally friendly approach for synthesizing palladium (Pd) nanoparticles supported on magnetic Fe3O4 microcapsules, using Strawberry fruit extract as both a capping- stabilizing and reducing agent. The synthesized Fe3O4@Strawberry/Pd nanocatalyst was thoroughly characterized using TEM, FT-IR, FE-SEM, EDX, XRD, and ICP-OES. The catalytic potential of the Fe3O4@Strawberry/Pd was applied in the Suzuki-Miyaura coupling reaction for the production of biphenyl derivatives from halo arenes and phenyl boronic acid. The outcomes demonstrated that the synthesized nanocatalyst is highly efficient, effective, and exhibits various advantages, like mild reaction system, high catalytic activity, and the ability to be reused for up to seven consecutive cycles. MTT assay was used on colorectal carcinoma (HT-29 and Ramos.2G6.4C10), gastric cancer (MKN45 and KATO III), pancreatic cancer (PANC-1 and MIA PaCa-2), and normal (HUVEC) cell lines for analyzing of cytotoxicity and anti-gastrointestinal system cancers effects of Fe3O4@Strawberry/Pd nanocatalyst. The nanoparticles had high cell death and anti-colorectal carcinoma, anti-gastric cancer, and anti-pancreatic cancer effects against HT-29, Ramos.2G6.4C10, MKN45, KATO III, PANC-1, and MIA PaCa-2 cell lines. Among the above cell lines, the best result of anti-cancer properties of Fe3O4@Strawberry/Pd nanocatalyst was gained in the cell line of Ramos.2G6.4C10. The above results confirm the excellent anti-gastrointestinal system cancers effects of Fe3O4@Strawberry/Pd nanocomposite.
{"title":"Development of magnetically retrievable nanostructure Pd catalyst supported over magnetic nanocomposite assisted by Strawberry fruit extract and its application in the Suzuki-Miyaura coupling reaction and anti-colorectal, anti-gastric, and anti-pancreatic cancer effects","authors":"Xin Yang , Hongrun Wu , Zaibo Wen","doi":"10.1016/j.jorganchem.2025.123616","DOIUrl":"10.1016/j.jorganchem.2025.123616","url":null,"abstract":"<div><div>In this work, we present a green and environmentally friendly approach for synthesizing palladium (Pd) nanoparticles supported on magnetic Fe<sub>3</sub>O<sub>4</sub> microcapsules, using <em>Strawberry</em> fruit extract as both a capping- stabilizing and reducing agent. The synthesized Fe<sub>3</sub>O<sub>4</sub>@<em>Strawberry</em>/Pd nanocatalyst was thoroughly characterized using TEM, FT-IR, FE-SEM, EDX, XRD, and ICP-OES. The catalytic potential of the Fe<sub>3</sub>O<sub>4</sub>@<em>Strawberry</em>/Pd was applied in the Suzuki-Miyaura coupling reaction for the production of biphenyl derivatives from halo arenes and phenyl boronic acid. The outcomes demonstrated that the synthesized nanocatalyst is highly efficient, effective, and exhibits various advantages, like mild reaction system, high catalytic activity, and the ability to be reused for up to seven consecutive cycles. MTT assay was used on colorectal carcinoma (HT-29 and Ramos.2G6.4C10), gastric cancer (MKN45 and KATO III), pancreatic cancer (PANC-1 and MIA PaCa-2), and normal (HUVEC) cell lines for analyzing of cytotoxicity and anti-gastrointestinal system cancers effects of Fe<sub>3</sub>O<sub>4</sub>@<em>Strawberry</em>/Pd nanocatalyst. The nanoparticles had high cell death and anti-colorectal carcinoma, anti-gastric cancer, and anti-pancreatic cancer effects against HT-29, Ramos.2G6.4C10, MKN45, KATO III, PANC-1, and MIA PaCa-2 cell lines. Among the above cell lines, the best result of anti-cancer properties of Fe<sub>3</sub>O<sub>4</sub>@<em>Strawberry</em>/Pd nanocatalyst was gained in the cell line of Ramos.2G6.4C10. The above results confirm the excellent anti-gastrointestinal system cancers effects of Fe<sub>3</sub>O<sub>4</sub>@<em>Strawberry</em>/Pd nanocomposite.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123616"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-09DOI: 10.1016/j.jorganchem.2025.123612
Ryuki Kuro-oka , Satoru Nakashima
Biruthenocene(RcRc) was oxidized with halogen to form [Rc(II)-Rc(IV)-X]+Y− (X = I, Br; Y = I3, Br3, BF4, PF6). The variable temperature (VT) 1H NMR showed the intermolecular effect on the valence detrapping only for [RcRc-I]+I3− by changing the concentration of the solution, while the other complexes did not show solution concentration dependence. This reveals that the intramolecular halogen exchange is a main mechanism for valence detrapping, while the intermolecular halogen exchange is added only for [RcRc-I]+I3−. This was suggested to be due to the equilibrium such as I3− ⇌ I2 + I−. This I− is thought to mediate I− exchange among mixed-valence cations (I− + I3− ⇌ I3− + I−, Grotthuss mechanism). On the other hand, [RcRc-Br]+Br3− did not show concentration dependence. The difference between the two adducts was suggested to be due to the difference in σ-hole density of halogen. VT 1H NMR of mixed compounds (each [Rc(II)-Rc(IV)-X]+Y− (X = I, Br; Y = I3, Br3, BF4, PF6) and RcRc) was also measured. The broadening of RcRc signal was observed in the mixed compounds for iodine adducts. It is considered that iodine adducts have an intermolecular exchange reaction with RcRc due to easier intermolecular transfer of adducted I−. In this case also the intermolecular exchange was shown to be significant for the valence detrapping for the mixture of [RcRc-I]+I3− and RcRc. On the other hand, bromine adducts with RcRc did not show the broadening of RcRc signal in the mixed compounds. The intramolecular valence detrapping in the mixed-valence [RcRc-Br]+ was dominant even in the mixture of [Rc(II)-Rc(IV)-Br]+Y− (Y = Br3, BF4, PF6) and RcRc. The difference between iodine adducts and bromine adducts in the mixture with RcRc agrees with the halogen trend for valence detrapping reported for the mixture of RcH and RcH-X+ (X = I, Br). It was suggested that σ-hole density of the halogen has an important role in the halogen transfer between RcRcX+ and RcRc. The solvent effect on halogen exchange was also discussed by considering the solvation of [Rc(II)-Rc(IV)-X]2+and Y−.
{"title":"Valence detrapping accompanied by intramolecular and intermolecular halogen exchange in the solution of the mixed-valence binuclear ruthenocenes","authors":"Ryuki Kuro-oka , Satoru Nakashima","doi":"10.1016/j.jorganchem.2025.123612","DOIUrl":"10.1016/j.jorganchem.2025.123612","url":null,"abstract":"<div><div>Biruthenocene(RcRc) was oxidized with halogen to form [Rc(II)-Rc(IV)-X]<sup>+</sup>Y<sup>−</sup> (X = I, Br; Y = I<sub>3</sub>, Br<sub>3</sub>, BF<sub>4</sub>, PF<sub>6</sub>). The variable temperature (VT) <sup>1</sup>H NMR showed the intermolecular effect on the valence detrapping only for [RcRc-I]<sup>+</sup>I<sub>3</sub><sup>−</sup> by changing the concentration of the solution, while the other complexes did not show solution concentration dependence. This reveals that the intramolecular halogen exchange is a main mechanism for valence detrapping, while the intermolecular halogen exchange is added only for [RcRc-I]<sup>+</sup>I<sub>3</sub><sup>−</sup>. This was suggested to be due to the equilibrium such as I<sub>3</sub><sup>−</sup> ⇌ I<sub>2</sub> + I<sup>−</sup>. This I<sup>−</sup> is thought to mediate I<sup>−</sup> exchange among mixed-valence cations (I<sup>−</sup> + I<sub>3</sub><sup>−</sup> ⇌ I<sub>3</sub><sup>−</sup> + I<sup>−</sup>, Grotthuss mechanism). On the other hand, [RcRc-Br]<sup>+</sup>Br<sub>3</sub><sup>−</sup> did not show concentration dependence. The difference between the two adducts was suggested to be due to the difference in σ-hole density of halogen. VT <sup>1</sup>H NMR of mixed compounds (each [Rc(II)-Rc(IV)-X]<sup>+</sup>Y<sup>−</sup> (X = I, Br; Y = I<sub>3</sub>, Br<sub>3</sub>, BF<sub>4</sub>, PF<sub>6</sub>) and RcRc) was also measured. The broadening of RcRc signal was observed in the mixed compounds for iodine adducts. It is considered that iodine adducts have an intermolecular exchange reaction with RcRc due to easier intermolecular transfer of adducted I<sup>−</sup>. In this case also the intermolecular exchange was shown to be significant for the valence detrapping for the mixture of [RcRc-I]<sup>+</sup>I<sub>3</sub><sup>−</sup> and RcRc. On the other hand, bromine adducts with RcRc did not show the broadening of RcRc signal in the mixed compounds. The intramolecular valence detrapping in the mixed-valence [RcRc-Br]<sup>+</sup> was dominant even in the mixture of [Rc(II)-Rc(IV)-Br]<sup>+</sup>Y<sup>−</sup> (Y = Br<sub>3</sub>, BF<sub>4</sub>, PF<sub>6</sub>) and RcRc. The difference between iodine adducts and bromine adducts in the mixture with RcRc agrees with the halogen trend for valence detrapping reported for the mixture of RcH and RcH-X<sup>+</sup> (X = I, Br). It was suggested that σ-hole density of the halogen has an important role in the halogen transfer between RcRcX<sup>+</sup> and RcRc. The solvent effect on halogen exchange was also discussed by considering the solvation of [Rc(II)-Rc(IV)-X]<sup>2+</sup>and Y<sup>−</sup>.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1032 ","pages":"Article 123612"},"PeriodicalIF":2.1,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-08DOI: 10.1016/j.jorganchem.2025.123613
Cheng Zhang , Jialu Liu , Danfeng He , Keyue Xu , Yuanyuan Fang , Wei Sun , Wenjing Xiong
Three mononuclear platinum (II) complexes piqPtOXD, 2niqPtOXD and PyriqPtOXD were synthesized using phenyl isoquinoline, naphthalene isoquinoline and pyrene isoquinoline as cyclometalated ligands and 1,3,4-oxadiazole derivatives as auxiliary ligands. The photophysical, electrochemical and electroluminescent properties were primarily investigated. It's observed that an increase in the rigid planar structure of the ligand cyclic aromatic hydrocarbons resulted in higher thermal stability, lower band gap values and red-shifted emission spectra. Theoretical calculations indicated that the decrease in the energy gap value of the complex PyriqPtOXD was due to the distribution of both the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy level on the platinum atoms and cyclometalated ligands. In addition, the electroluminescence (EL) peak of the devices based on PyriqPtOXD reached 742 nm, which was 140 nm red-shifted compared to the piqPtOXD-based devices, with a maximum irradiance of 36 μW/cm2 and a maximum external quantum efficiency (EQEmax) of 0.35 %.
{"title":"Achieving deep red to near-infrared electroluminescence in platinum complex through enhanced conjugation of the ligand","authors":"Cheng Zhang , Jialu Liu , Danfeng He , Keyue Xu , Yuanyuan Fang , Wei Sun , Wenjing Xiong","doi":"10.1016/j.jorganchem.2025.123613","DOIUrl":"10.1016/j.jorganchem.2025.123613","url":null,"abstract":"<div><div>Three mononuclear platinum (II) complexes <strong>piqPtOXD, 2niqPtOXD</strong> and <strong>PyriqPtOXD</strong> were synthesized using phenyl isoquinoline, naphthalene isoquinoline and pyrene isoquinoline as cyclometalated ligands and 1,3,4-oxadiazole derivatives as auxiliary ligands. The photophysical, electrochemical and electroluminescent properties were primarily investigated. It's observed that an increase in the rigid planar structure of the ligand cyclic aromatic hydrocarbons resulted in higher thermal stability, lower band gap values and red-shifted emission spectra. Theoretical calculations indicated that the decrease in the energy gap value of the complex <strong>PyriqPtOXD</strong> was due to the distribution of both the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy level on the platinum atoms and cyclometalated ligands. In addition, the electroluminescence (EL) peak of the devices based on <strong>PyriqPtOXD</strong> reached 742 nm, which was 140 nm red-shifted compared to the <strong>piqPtOXD-</strong>based devices, with a maximum irradiance of 36 <em>μ</em>W/cm<sup>2</sup> and a maximum external quantum efficiency (<em>EQE</em><sub>max</sub>) of 0.35 %.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1031 ","pages":"Article 123613"},"PeriodicalIF":2.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-08DOI: 10.1016/j.jorganchem.2025.123614
Lei Rao, Dingsa Dong, Lu Hong, Ke Chen, Yue Sun, Hao Zhang, Lingjing Jiang, Wenxin Lin, Fengfeng Chen
Metal-organic frameworks (MOFs) had unique advantages and attracted much attentions as catalysts for Knoevenagel condensation. In this work, ZJU-64 series MOFs (ZJU-64, ZJU-64-CH3 and ZJU-64-NH2) with acid-base sites were synthesized by solvothermal method and employed as heterogeneous catalysts for Knoevenagel condensation. The catalysts showed high catalytic yields in the reaction, which were directly affected by reaction temperature and time. The catalytic yield of ZJU-64 and ZJU-64-CH3 at 75 °C for 1 hour was 96.92 % and 92.11 %, while that of ZJU-64-NH2 was 97.76 %, displaying high catalytic yields. Furthermore, they remained activity in Knoevenagel condensation without significant degradation, indicating they were promising polyphase Knoevenagel condensation catalysts. ZJU-64-NH2 showed excellent catalytic yield and revealed that the introduction of amino group could improve the catalytic performance of Zn-based MOFs.
{"title":"Study on catalytic performances of ZJU-64 series MOFs with acid-base sites for Knoevenagel condensation","authors":"Lei Rao, Dingsa Dong, Lu Hong, Ke Chen, Yue Sun, Hao Zhang, Lingjing Jiang, Wenxin Lin, Fengfeng Chen","doi":"10.1016/j.jorganchem.2025.123614","DOIUrl":"10.1016/j.jorganchem.2025.123614","url":null,"abstract":"<div><div>Metal-organic frameworks (MOFs) had unique advantages and attracted much attentions as catalysts for Knoevenagel condensation. In this work, ZJU-64 series MOFs (ZJU-64, ZJU-64-CH<sub>3</sub> and ZJU-64-NH<sub>2</sub>) with acid-base sites were synthesized by solvothermal method and employed as heterogeneous catalysts for Knoevenagel condensation. The catalysts showed high catalytic yields in the reaction, which were directly affected by reaction temperature and time. The catalytic yield of ZJU-64 and ZJU-64-CH<sub>3</sub> at 75 °C for 1 hour was 96.92 % and 92.11 %, while that of ZJU-64-NH<sub>2</sub> was 97.76 %, displaying high catalytic yields. Furthermore, they remained activity in Knoevenagel condensation without significant degradation, indicating they were promising polyphase Knoevenagel condensation catalysts. ZJU-64-NH<sub>2</sub> showed excellent catalytic yield and revealed that the introduction of amino group could improve the catalytic performance of Zn-based MOFs.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1031 ","pages":"Article 123614"},"PeriodicalIF":2.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号