Pub Date : 2025-11-21DOI: 10.1016/j.jorganchem.2025.123957
Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. El Sabban
In this inclusive innovation research, we have successfully synthesized mono-dispersed silver nanoparticles mediated by Pistacia leaves extract as reducing and stabilizing agent. The reduction in Ag+ ions to Ag0 nanoparticles was visually proved by a change in color from green to gray color. The present study employs numerous analytical methods like UV–Vis, FT-IR, TEM, SEM, EDX, ICP-OES, elemental mapping, XRD to identify the characteristics of the Ag NPs/Pistacia nanocomposite. TEM analysis revealed the spherical shapes of nanoparticles that have sizes of around 20–30 nm. Due to Importance of pyrano[2,3-d]pyrimidines in pharmaceutical science and their pharmacological activities, we interested to apply Ag NPs/Pistacia as efficient catalyst in the production of pyrano[2,3-d]pyrimidines via a three-component condensation that included barbituric acid, aryl aldehydes, and malononitrile. Furthermore, the Ag NPs/Pistacia catalyst demonstrated commendable recyclability, sustaining its catalytic efficacy after being utilized 7 times with minimal reduction in performance. Easy separation of products, purification without need to column chromatographic, and use of commercially available low-cost substrates make the protocol viable in organic synthesis.
{"title":"Green synthesis of silver nanoparticles as an efficient catalyst for one-pot preparation of pyrano[2,3-d]pyrimidines","authors":"Ali M Hussein , Narinderjit Singh Sawaran Singh , Luma Hussain Saleh , Malatesh Akkur , Satish Kumar Samal , Sridharan Sundharam , Sanjeev Kumar , Khalmurat Iliev , Zukhra Atamuratova , Davronbek Yulchiev , Aseel Smerat , H. El Sabban","doi":"10.1016/j.jorganchem.2025.123957","DOIUrl":"10.1016/j.jorganchem.2025.123957","url":null,"abstract":"<div><div>In this inclusive innovation research, we have successfully synthesized mono-dispersed silver nanoparticles mediated by <em>Pistacia</em> leaves extract as reducing and stabilizing agent. The reduction in Ag<sup>+</sup> ions to Ag<sup>0</sup> nanoparticles was visually proved by a change in color from green to gray color. The present study employs numerous analytical methods like UV–Vis, FT-IR, TEM, SEM, EDX, ICP-OES, elemental mapping, XRD to identify the characteristics of the Ag NPs/<em>Pistacia</em> nanocomposite. TEM analysis revealed the spherical shapes of nanoparticles that have sizes of around 20–30 nm. Due to Importance of pyrano[2,3-d]pyrimidines in pharmaceutical science and their pharmacological activities, we interested to apply Ag NPs/<em>Pistacia</em> as efficient catalyst in the production of pyrano[2,3-d]pyrimidines via a three-component condensation that included barbituric acid, aryl aldehydes, and malononitrile. Furthermore, the Ag NPs/<em>Pistacia</em> catalyst demonstrated commendable recyclability, sustaining its catalytic efficacy after being utilized 7 times with minimal reduction in performance. Easy separation of products, purification without need to column chromatographic, and use of commercially available low-cost substrates make the protocol viable in organic synthesis.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123957"},"PeriodicalIF":2.1,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.jorganchem.2025.123943
Rayya A. Al Balushi , Najat Al Riyami , Ashanul Haque , Khalaf M. Alenezi , Muhammad S. Khan , Jonathan M. Skelton
This work reports the synthesis, thermal characterization and optical characterization of a novel Pt(II) di‑yne (M) and poly‑yne (P) incorporating a seven-ring fused (2,8-disubstituted-6,12-dihydro-6,6,12,12-tetrakis(4-octylphenyl)-dithieno[2,3-d:2′,3′-d′]-s-indaceno[1,2-b:5,6-b′]dithiophene) spacer. The nature of the electronic excitation and the effect of conjugation were studied using time-dependent density-functional theory (TD-DFT) calculations. The model complex (M) and the poly‑yne (P) were used as donor materials to fabricate bulk heterojunction polymer solar cells (PSCs) by blending with a [6,6]-phenyl C71-butyric acid methyl ester (PC71BM) as an electron acceptor. The materials show high thermal stability and absorption in the visible region of the spectrum. Computational modelling shows that alkynylation of the fused dithienoindacenodithiophene spacer, and its subsequent incorporation into a Pt(II) di‑yne, results in a reduction of the HOMO-LUMO gap and concomitant red shift of the absorption edge, and a significant enhancement in the oscillator strength. Both M and P were found to show low photovoltaic performance, tentatively attributed to a limited absorption profile. Overall, this study sheds light on a new member of the family of Pt(II) di-ynes and poly-ynes, for which the electronic properties of the materials can be tuned via linker groups with extended aromatic character.
{"title":"Synthesis, characterization, and photovoltaic performance of two new platina-ynes functionalized with seven-ring fused dithienoindacenodithiophene spacers","authors":"Rayya A. Al Balushi , Najat Al Riyami , Ashanul Haque , Khalaf M. Alenezi , Muhammad S. Khan , Jonathan M. Skelton","doi":"10.1016/j.jorganchem.2025.123943","DOIUrl":"10.1016/j.jorganchem.2025.123943","url":null,"abstract":"<div><div>This work reports the synthesis, thermal characterization and optical characterization of a novel Pt(II) di‑yne (<strong>M</strong>) and poly‑yne (<strong>P</strong>) incorporating a seven-ring fused (2,8-disubstituted-6,12-dihydro-6,6,12,12-tetrakis(4-octylphenyl)-dithieno[2,3-d:2′,3′-d′]-s-indaceno[1,2-b:5,6-b′]dithiophene) spacer. The nature of the electronic excitation and the effect of conjugation were studied using time-dependent density-functional theory (TD-DFT) calculations. The model complex (<strong>M</strong>) and the poly‑yne (<strong>P</strong>) were used as donor materials to fabricate bulk heterojunction polymer solar cells (PSCs) by blending with a [6,6]-phenyl C<sub>71</sub>-butyric acid methyl ester (PC<sub>71</sub>BM) as an electron acceptor. The materials show high thermal stability and absorption in the visible region of the spectrum. Computational modelling shows that alkynylation of the fused dithienoindacenodithiophene spacer, and its subsequent incorporation into a Pt(II) di‑yne, results in a reduction of the HOMO-LUMO gap and concomitant red shift of the absorption edge, and a significant enhancement in the oscillator strength. Both <strong>M</strong> and <strong>P</strong> were found to show low photovoltaic performance, tentatively attributed to a limited absorption profile. Overall, this study sheds light on a new member of the family of Pt(II) di-ynes and poly-ynes, for which the electronic properties of the materials can be tuned <em>via</em> linker groups with extended aromatic character.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123943"},"PeriodicalIF":2.1,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.jorganchem.2025.123954
Alberto Reyes-Deloso , Juan Guillermo Robledo-Ayala , Emir A. Galván-García , Rodolfo Goméz-Balderas , José Guillermo Penieres-Carrillo , Fernando Ortega-Jiménez
We report the efficient synthesis and characterization of novel non-symmetric Pd-CNN pincer complexes via C–H bond activation on arylhydrazone-thioether ligands, which serve as effective catalytic precursors for carbonylative Suzuki coupling reactions. The complexes were synthesized using arylhydrazone-thiazolyne ligands, exhibiting enhanced stability and reactivity under ambient conditions. Their catalytic performance was evaluated using Fe(CO)5 as a carbon monoxide surrogate, addressing the limitations of traditional methods that often involve toxic CO(g) sources. Actually, Fe(CO)₅ is considered a more practical CO source compared to gaseous CO due to its safer handling and ability to release CO in a controlled manner under reaction conditions; additionally, it is commercially available, cost-effective, and generates minimal metal waste, offering a more sustainable alternative for carbonylative transformations in synthetic chemistry. The optimized reaction conditions yielded significant product formation, with various aryl and heteroaryl halides successfully coupled to produce biaryl ketones, including an antineoplastic agent. The findings highlight the versatility and efficiency of the synthesized pincer complexes in carbonylative Suzuki coupling, paving the way for safer and more effective synthetic methodologies in organic chemistry. A computational study of the Suzuki carbonylative coupling catalytic cycle, using Fe(CO)5 as the CO source, revealed low energy barriers for key steps and a favorable overall energy profile (ΔE = –33.96 kcal/mol), supporting the experimental efficiency observed. The evaluation of two alternative mechanistic pathways showed that the initial CO coordination plays a decisive thermodynamic role in determining the preferred route through the catalytic cycle, balancing kinetic accessibility and overall stability. These results are consistent with the suitability of Fe(CO)5 as an effective CO surrogate in carbonylative cross-coupling reactions.
{"title":"Arylhydrazone–thiazolyne derived Pd–CNN pincer complexes for carbonylative Suzuki coupling, via iron pentacarbonyl as a sustainable CO surrogate","authors":"Alberto Reyes-Deloso , Juan Guillermo Robledo-Ayala , Emir A. Galván-García , Rodolfo Goméz-Balderas , José Guillermo Penieres-Carrillo , Fernando Ortega-Jiménez","doi":"10.1016/j.jorganchem.2025.123954","DOIUrl":"10.1016/j.jorganchem.2025.123954","url":null,"abstract":"<div><div>We report the efficient synthesis and characterization of novel non-symmetric Pd-CNN pincer complexes via C–H bond activation on arylhydrazone-thioether ligands, which serve as effective catalytic precursors for carbonylative Suzuki coupling reactions. The complexes were synthesized using arylhydrazone-thiazolyne ligands, exhibiting enhanced stability and reactivity under ambient conditions. Their catalytic performance was evaluated using Fe(CO)<sub>5</sub> as a carbon monoxide surrogate, addressing the limitations of traditional methods that often involve toxic CO<sub>(g)</sub> sources. Actually, Fe(CO)₅ is considered a more practical CO source compared to gaseous CO due to its safer handling and ability to release CO in a controlled manner under reaction conditions; additionally, it is commercially available, cost-effective, and generates minimal metal waste, offering a more sustainable alternative for carbonylative transformations in synthetic chemistry. The optimized reaction conditions yielded significant product formation, with various aryl and heteroaryl halides successfully coupled to produce biaryl ketones, including an antineoplastic agent. The findings highlight the versatility and efficiency of the synthesized pincer complexes in carbonylative Suzuki coupling, paving the way for safer and more effective synthetic methodologies in organic chemistry. A computational study of the Suzuki carbonylative coupling catalytic cycle, using Fe(CO)<sub>5</sub> as the CO source, revealed low energy barriers for key steps and a favorable overall energy profile (ΔE = –33.96 kcal/mol), supporting the experimental efficiency observed. The evaluation of two alternative mechanistic pathways showed that the initial CO coordination plays a decisive thermodynamic role in determining the preferred route through the catalytic cycle, balancing kinetic accessibility and overall stability. These results are consistent with the suitability of Fe(CO)<sub>5</sub> as an effective CO surrogate in carbonylative cross-coupling reactions.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123954"},"PeriodicalIF":2.1,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.jorganchem.2025.123956
Touhami Lanez, Meriem Henni
This study reports the systematic evaluation of ferrocenylmethylcyanophenyl (FcCN) and ferrocenylmethylcyanophenylacetamide (FcCNCO) derivatives as dual anti-inflammatory and antidiabetic agents. The FcCN derivatives were synthesized via nucleophilic substitution of aminobenzonitrile on methylenic carbons adjacent to quaternary ammonium centers, followed by acylation with acetic anhydride to yield the corresponding FcCNCO derivatives. These well-established reactions constitute a reliable and reproducible synthetic framework for the preparation of the target compounds. In vitro assays demonstrated that Fc2CNCO exhibited superior anti-inflammatory activity (IC50 = 4.17 µM) compared to diclofenac (IC50= 6.40 µM), while Fc4CNCO strongly inhibited α-amylase (IC50 = 1.15 µM), approaching the potency of acarbose (IC50= 0.33 µM). Molecular docking and 100 ns molecular dynamics simulations confirmed stable protein–ligand interactions, consistent with the experimental results, and highlighted the key roles of hydrogen bonding, hydrophobic contacts, and π–stacking in driving selectivity. Structure–activity relationship analysis revealed substitution-dependent trends: ortho-acetamide substitution enhanced anti-inflammatory potency, whereas para-substitution favored α-amylase inhibition. These findings establish ferrocenyl scaffolds as promising multifunctional drug leads and provide rational design principles for future agents targeting comorbid inflammatory and metabolic disorders.
{"title":"Dual anti-inflammatory and antidiabetic potential of ferrocenylmethylcyanophenyl derivatives: Integrated In Vitro and In Silico evaluation","authors":"Touhami Lanez, Meriem Henni","doi":"10.1016/j.jorganchem.2025.123956","DOIUrl":"10.1016/j.jorganchem.2025.123956","url":null,"abstract":"<div><div>This study reports the systematic evaluation of ferrocenylmethylcyanophenyl (FcCN) and ferrocenylmethylcyanophenylacetamide (FcCNCO) derivatives as dual anti-inflammatory and antidiabetic agents. The FcCN derivatives were synthesized via nucleophilic substitution of aminobenzonitrile on methylenic carbons adjacent to quaternary ammonium centers, followed by acylation with acetic anhydride to yield the corresponding FcCNCO derivatives. These well-established reactions constitute a reliable and reproducible synthetic framework for the preparation of the target compounds. In vitro assays demonstrated that Fc2CNCO exhibited superior anti-inflammatory activity (IC<sub>50</sub> = 4.17 µM) compared to diclofenac (IC<sub>50</sub>= 6.40 µM), while Fc4CNCO strongly inhibited α-amylase (IC<sub>50</sub> = 1.15 µM), approaching the potency of acarbose (IC<sub>50</sub>= 0.33 µM). Molecular docking and 100 ns molecular dynamics simulations confirmed stable protein–ligand interactions, consistent with the experimental results, and highlighted the key roles of hydrogen bonding, hydrophobic contacts, and π–stacking in driving selectivity. Structure–activity relationship analysis revealed substitution-dependent trends: ortho-acetamide substitution enhanced anti-inflammatory potency, whereas para-substitution favored α-amylase inhibition. These findings establish ferrocenyl scaffolds as promising multifunctional drug leads and provide rational design principles for future agents targeting comorbid inflammatory and metabolic disorders.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123956"},"PeriodicalIF":2.1,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.jorganchem.2025.123952
Huijun Yuan , Min Pei , Baoqing Lv , Dongyu Mei , Yongchang Zhou , Le Wang , Xiuying Pu , Tiankun Zhao
2-Nitroethenyl ferrocene (NVFc) was synthesized in excellent yield via a condensation reaction between ferrocenecarboxaldehyde and nitromethane. The compound was fully characterized using 1H and 13C NMR spectroscopy, UV-Vis spectroscopy, high-resolution mass spectrometry (HRMS), and X-ray crystallography. Under dark conditions, NVFc exhibited negligible cytotoxicity against Hep G2 and HeLa S3 tumor cell lines. However, upon visible light irradiation (400–625 nm) for 10 minutes, its photodynamic cytotoxicity increased markedly. The most pronounced phototoxic effect was observed in HeLa S3 cells under 520 nm light exposure, with an IC50 of 3.52 ± 1.31 μM. For Hep G2 cells, maximal photocytotoxicity occurred under 620 nm irradiation, with an IC50 of 2.81 ± 0.95 μM. Mechanistic investigations revealed that NVFc promotes the generation of reactive oxygen species (ROS), with a singlet oxygen (1O2) quantum yield (ΦΔ) of 76.5% in DMSO/PBS (1:199, v/v), which is higher than that of several clinically used organic photosensitizers. NVFc also caused a marked reduction in mitochondrial membrane potential (MMP) in HeLa S3 cells, indicating that mitochondrial dysfunction plays a central role in its cytotoxic activity. In addition, NVFc was found to induce ferroptosis, as evidenced by the downregulation of key ferroptosis-related proteins, GPX4 and SLC7A11.
{"title":"2-nitroethenyl ferrocene as a photosensitizer: Evaluation of its photodynamic antitumor properties","authors":"Huijun Yuan , Min Pei , Baoqing Lv , Dongyu Mei , Yongchang Zhou , Le Wang , Xiuying Pu , Tiankun Zhao","doi":"10.1016/j.jorganchem.2025.123952","DOIUrl":"10.1016/j.jorganchem.2025.123952","url":null,"abstract":"<div><div>2-Nitroethenyl ferrocene (<strong>NVFc</strong>) was synthesized in excellent yield <em>via</em> a condensation reaction between ferrocenecarboxaldehyde and nitromethane. The compound was fully characterized using <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, UV-Vis spectroscopy, high-resolution mass spectrometry (HRMS), and X-ray crystallography. Under dark conditions, <strong>NVFc</strong> exhibited negligible cytotoxicity against Hep G2 and HeLa S3 tumor cell lines. However, upon visible light irradiation (400–625 nm) for 10 minutes, its photodynamic cytotoxicity increased markedly. The most pronounced phototoxic effect was observed in HeLa S3 cells under 520 nm light exposure, with an IC<sub>50</sub> of 3.52 ± 1.31 μM. For Hep G2 cells, maximal photocytotoxicity occurred under 620 nm irradiation, with an IC<sub>50</sub> of 2.81 ± 0.95 μM. Mechanistic investigations revealed that <strong>NVFc</strong> promotes the generation of reactive oxygen species (ROS), with a singlet oxygen (<sup>1</sup>O<sub>2</sub>) quantum yield (ΦΔ) of 76.5% in DMSO/PBS (1:199, <em>v/v</em>), which is higher than that of several clinically used organic photosensitizers. <strong>NVFc</strong> also caused a marked reduction in mitochondrial membrane potential (MMP) in HeLa S3 cells, indicating that mitochondrial dysfunction plays a central role in its cytotoxic activity. In addition, <strong>NVFc</strong> was found to induce ferroptosis, as evidenced by the downregulation of key ferroptosis-related proteins, GPX4 and SLC7A11.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123952"},"PeriodicalIF":2.1,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.jorganchem.2025.123944
Ashutosh Mishra , Rehana Shahin , Kanchan Sharma , Shaifali Mishra , Satyanath , Rajesh Kumar Yadav , Navneet K. Gupta , Jin OoK Baeg
The development of efficient photocatalytic materials is crucial for advancing renewable energy technologies and sustainable energy conversion. In this study, we report the design and synthesis of a sulfur-bridged 2,4,6-tribromoaniline (TBA@S) polymeric composite photocatalyst for solar-driven chemical synthesis and selective regeneration of nicotinamide adenine dinucleotide (NADH) cofactors. NADH is central to numerous biochemical reactions, including cellular energy production, making its efficient regeneration highly desirable for bio-inspired catalytic processes. The TBA framework was selected for its robust stability under reaction conditions, while the introduction of sulfur bridges provides electron-rich centers that facilitate charge transfer and enhance light-driven catalytic efficiency. These features collectively improve the photocatalytic activity of TBA@S. The photocatalyst achieved selective NADH regeneration (60.02%) via a penta-methylcyclopentadienyl-rhodium-bipyridine complex ([Cp*Rh(bpy)(H₂O)]²⁺), along with solar chemical synthesis of a Biginelli product (81%) under solar irradiation. Overall, the newly developed TBA@S polymer composite demonstrates strong potential for cofactor regeneration and solar fine chemical production, highlighting its relevance for sustainable catalytic applications.
{"title":"Hybrid photocatalytic system: Penta-methylcyclopentadienyl-rhodium-bipyridine complex and sulfur-bridged TBA polymer for enhanced cofactor regeneration and solar-driven chemical synthesis","authors":"Ashutosh Mishra , Rehana Shahin , Kanchan Sharma , Shaifali Mishra , Satyanath , Rajesh Kumar Yadav , Navneet K. Gupta , Jin OoK Baeg","doi":"10.1016/j.jorganchem.2025.123944","DOIUrl":"10.1016/j.jorganchem.2025.123944","url":null,"abstract":"<div><div>The development of efficient photocatalytic materials is crucial for advancing renewable energy technologies and sustainable energy conversion. In this study, we report the design and synthesis of a sulfur-bridged 2,4,6-tribromoaniline (TBA@S) polymeric composite photocatalyst for solar-driven chemical synthesis and selective regeneration of nicotinamide adenine dinucleotide (NADH) cofactors. NADH is central to numerous biochemical reactions, including cellular energy production, making its efficient regeneration highly desirable for bio-inspired catalytic processes. The TBA framework was selected for its robust stability under reaction conditions, while the introduction of sulfur bridges provides electron-rich centers that facilitate charge transfer and enhance light-driven catalytic efficiency. These features collectively improve the photocatalytic activity of TBA@S. The photocatalyst achieved selective NADH regeneration (60.02%) via a penta-methylcyclopentadienyl-rhodium-bipyridine complex ([Cp*Rh(bpy)(H₂O)]²⁺), along with solar chemical synthesis of a Biginelli product (81%) under solar irradiation. Overall, the newly developed TBA@S polymer composite demonstrates strong potential for cofactor regeneration and solar fine chemical production, highlighting its relevance for sustainable catalytic applications.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123944"},"PeriodicalIF":2.1,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1016/j.jorganchem.2025.123953
Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P.R. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , Mustafa Diab , H. Amin El Sabban
Bioinspired creation of mono-dispersed nickel nanoparticles was done using an aqueous flower extract of Lavandula angustifolia. The desired extract acted both as a reducing agent and as a stabilizer for the nanoparticles. Comprehensive characterization via inclusive innovation techniques TEM, FE-SEM, EDX, ICP-OES, and elemental-mapping confirmed the creation of the NiO NPs@L. angustifolia material. TEM revealed spherical nanoparticles with a narrow size distribution, nearing ∼10 nm. The produced NiO NPs@L. angustifolia showed impressive results in the CC cross-coupling Suzuki-Miyaura reaction, yielding high amounts of biaryl compounds. The catalyst illustrated good stability and heterogeneous properties, as verified by hot filtration tests. In addition, the catalyst could be reused for 6 cycles with only a minor decrease in its efficiency for C–C bond formation.
{"title":"Green synthesis of nickel nanoparticles mediated by Lavandula angustifolia extract: Investigation of its catalytic activity in Suzuki coupling reactions","authors":"Narinderjit Singh Sawaran Singh , Waqid Al-Mussawi , P.R. Jangir , Muktha Eti , Tanmoy Prida , S. Radhika , Gaganjot Kaur , Erkaboy Davletov , Usmonjon Akhmedov , Alisher Abduvokhidov , Mustafa Diab , H. Amin El Sabban","doi":"10.1016/j.jorganchem.2025.123953","DOIUrl":"10.1016/j.jorganchem.2025.123953","url":null,"abstract":"<div><div>Bioinspired creation of mono-dispersed nickel nanoparticles was done using an aqueous flower extract of <em>Lavandula angustifolia</em>. The desired extract acted both as a reducing agent and as a stabilizer for the nanoparticles. Comprehensive characterization via inclusive innovation techniques TEM, FE-SEM, EDX, ICP-OES, and elemental-mapping confirmed the creation of the NiO NPs@L. <em>angustifolia</em> material. TEM revealed spherical nanoparticles with a narrow size distribution, nearing ∼10 nm. The produced NiO NPs@L. <em>angustifolia</em> showed impressive results in the C<img>C cross-coupling Suzuki-Miyaura reaction, yielding high amounts of biaryl compounds. The catalyst illustrated good stability and heterogeneous properties, as verified by hot filtration tests. In addition, the catalyst could be reused for 6 cycles with only a minor decrease in its efficiency for C–C bond formation.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123953"},"PeriodicalIF":2.1,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.jorganchem.2025.123945
Mohammad Abushuhel , Hayjaa Mohaisen Mousa , G. PadmaPriya , Ahmad-Al Shaker , Subhashree Ray , Amrita Pal , Renu Sharma , Ashish Singh Chauhan , Kamran Hedayat
In the present research study, the Fe₃O₄–GO@Mn magnetic nanocatalyst was synthesized and successfully characterized by a range of techniques (XRD, FTIR, TEM, SEM, EDS, VSM, BET, and XPS) for a comprehensive characterization. This nanocomposite has good catalytic and magnetic characteristics because it has a Fe₃O₄ magnetic core, Mn layers, and is supported by graphene oxide; it is magnetic and allows for simple separation and multiple recycling. The reaction should be successful using this nanocatalyst for the synthesis of a variety of 1,2,3-triazole compounds with high efficiency and shorter reaction time, which was recommended under optimal conditions (temperature 80 °C, ethanol/water solvent, and time 40 min). Moreover, using a variety of substrates also showed the potential of the nanocatalyst to react with a diverse set of substrates, indicating good performance and versatility. The structural and functional stability of this nanocatalyst was confirmed, considering multiple recycling cycles, making it a choice for the industries and green chemistry.
{"title":"Development of Fe3O4–GO@Mn magnetic nanocatalyst for green synthesis of 1,2,3-triazole derivatives","authors":"Mohammad Abushuhel , Hayjaa Mohaisen Mousa , G. PadmaPriya , Ahmad-Al Shaker , Subhashree Ray , Amrita Pal , Renu Sharma , Ashish Singh Chauhan , Kamran Hedayat","doi":"10.1016/j.jorganchem.2025.123945","DOIUrl":"10.1016/j.jorganchem.2025.123945","url":null,"abstract":"<div><div>In the present research study, the Fe₃O₄–GO@Mn magnetic nanocatalyst was synthesized and successfully characterized by a range of techniques (XRD, FTIR, TEM, SEM, EDS, VSM, BET, and XPS) for a comprehensive characterization. This nanocomposite has good catalytic and magnetic characteristics because it has a Fe₃O₄ magnetic core, Mn layers, and is supported by graphene oxide; it is magnetic and allows for simple separation and multiple recycling. The reaction should be successful using this nanocatalyst for the synthesis of a variety of 1,2,3-triazole compounds with high efficiency and shorter reaction time, which was recommended under optimal conditions (temperature 80 °C, ethanol/water solvent, and time 40 min). Moreover, using a variety of substrates also showed the potential of the nanocatalyst to react with a diverse set of substrates, indicating good performance and versatility. The structural and functional stability of this nanocatalyst was confirmed, considering multiple recycling cycles, making it a choice for the industries and green chemistry.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123945"},"PeriodicalIF":2.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.jorganchem.2025.123942
Afroz Gul , Erdal Yabalak , Yahya Nural
Tetracyclines are well known for their diverse applications, including the treatment of various infections, the promotion of growth in poultry and cattle, and their use in animal husbandry. However, extended exposure to these antibiotics can lead to health problems and environmental pollution. This necessitates the development of time-saving and environmentally friendly devices, such as chemosensors, for their effective detection. This review provides a detailed account of the applications of the chemosensors as detection tools for tetracyclines, where metal-organic frameworks, metal coordination polymers and nanomaterials are considered as the main categories of these probes. The review highlights current research on the topic, shedding light on different types of chemosensors and their mechanisms of interaction with tetracyclines. Real-sample applications, test-strip determinations and smartphone-assisted detection methods are also briefly discussed. The review also draws attention to some of the areas where research is required. As the review presents the current state of progress in the detection of tetracyclines using chemosensors, it is hoped that it can be used as a stepping stone for future research.
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We report the reactivity of cationic Ru(II) pincer complexes [Ru(CNCMe)(CNMe)I]PF6 (1a), [Ru(CNCi-Pr)(CNMe)I]PF6 (1b) and [Ru(CNCCy)(CNMe)I]PF6 (1c) with CH3CN and PPh3 ligands and afforded dicationic Ru(II)-CNC pincer complexes namely, [Ru(CNCMe)(CNMe)CH3CN]2PF6 (2a), [Ru(CNCi-Pr)(CNMe)CH3CN]2PF6 (2b), [Ru(CNCCy)(CNMe)CH3CN]2PF6 (2c), [Ru(CNCMe)(CNMe)PPh3]2PF6 (3a), [Ru(CNCi-Pr)(CNMe)PPh3]2PF6 (3b) and [Ru(CNCCy)(CNMe)PPh3]2PF6 (3c). All the new complexes were characterized spectroscopically by multinuclear NMR and HRMS, and molecular structures of complexes 2a and 3a have been determined by the single-crystal X-ray diffraction technique. The structures and electronic properties of all complexes are probed through UV–vis and electrochemical investigations for a comparison of ancillary ligand effects. Investigation of the catalytic activity of new complexes towards nitrile hydration reveals that the reaction proceeds through a common Ru-OH intermediate generated by removal of the I−, CH3CN, or PPh3 ligands, and I− based catalysts (1a-c) are more active than those with CH3CN (2a-c) and PPh3 (3a-c) ligands.
{"title":"Syntheses, structures, and catalytic investigation of dicationic ruthenium(II)-CNC pincer complexes with multiple NHCs donor ligands","authors":"Rahul Kumar Singh , Dibya Yadav , Ashu Singh , Shilpi Misra , Amrendra K. Singh","doi":"10.1016/j.jorganchem.2025.123939","DOIUrl":"10.1016/j.jorganchem.2025.123939","url":null,"abstract":"<div><div>We report the reactivity of cationic Ru(II) pincer complexes [Ru(CNC<sup>Me</sup>)(CN<sup>Me</sup>)I]PF<sub>6</sub> (<strong>1a</strong>), [Ru(CNC<em><sup>i-</sup></em><sup>Pr</sup>)(CN<sup>Me</sup>)I]PF<sub>6</sub> (<strong>1b</strong>) and [Ru(CNC<sup>Cy</sup>)(CN<sup>Me</sup>)I]PF<sub>6</sub> (<strong>1c</strong>) with CH<sub>3</sub>CN and PPh<sub>3</sub> ligands and afforded dicationic Ru(II)-CNC pincer complexes namely, [Ru(CNC<sup>Me</sup>)(CN<sup>Me</sup>)CH<sub>3</sub>CN]2PF<sub>6</sub> (<strong>2a</strong>), [Ru(CNC<em><sup>i-</sup></em><sup>Pr</sup>)(CN<sup>Me</sup>)CH<sub>3</sub>CN]2PF<sub>6</sub> (<strong>2b</strong>), [Ru(CNC<sup>Cy</sup>)(CN<sup>Me</sup>)CH<sub>3</sub>CN]2PF<sub>6</sub> (<strong>2c</strong>), [Ru(CNC<sup>Me</sup>)(CN<sup>Me</sup>)PPh<sub>3</sub>]2PF<sub>6</sub> (<strong>3a</strong>), [Ru(CNC<em><sup>i-</sup></em><sup>Pr</sup>)(CN<sup>Me</sup>)PPh<sub>3</sub>]2PF<sub>6</sub> (<strong>3b</strong>) and [Ru(CNC<sup>Cy</sup>)(CN<sup>Me</sup>)PPh<sub>3</sub>]2PF<sub>6</sub> (<strong>3c</strong>). All the new complexes were characterized spectroscopically by multinuclear NMR and HRMS, and molecular structures of complexes <strong>2a</strong> and <strong>3a</strong> have been determined by the single-crystal X-ray diffraction technique. The structures and electronic properties of all complexes are probed through UV–vis and electrochemical investigations for a comparison of ancillary ligand effects. Investigation of the catalytic activity of new complexes towards nitrile hydration reveals that the reaction proceeds through a common Ru-OH intermediate generated by removal of the I<sup>−</sup>, CH<sub>3</sub>CN, or PPh<sub>3</sub> ligands, and I<sup>−</sup> based catalysts (<strong>1a</strong>-<strong>c</strong>) are more active than those with CH<sub>3</sub>CN (<strong>2a</strong>-<strong>c</strong>) and PPh<sub>3</sub> (<strong>3a</strong>-<strong>c</strong>) ligands.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123939"},"PeriodicalIF":2.1,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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