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Effects of mental disorders on the relationship between physical activity and bone markers among depressed patients in Germany 精神障碍对德国抑郁症患者体力活动与骨骼指标关系的影响

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Preventive Medicine Reports

Pub Date : 2026-01-01 DOI: 10.1016/j.pmedr.2025.103364

Sanne Houtenbos , Yangyang He , Andrea Block , Pia-Maria Wippert

Objective

Physical activity (PHYA) positively influences bone health, but this relationship might be affected by mental disorders. Aims: (1) evaluate whether mental disorders influence bone markers and (2) whether the relationship of PHYA with bone markers is influenced by mental disorders.

Methods

A secondary data analysis of the longitudinal DEPREHA-study (Germany, 18 months, n = 208, 18-65y, ICD-10 F32.x-F33.x, collected 2015–2017) was conducted. Baseline data: sociodemographic, PHYA, depressive (BDI-II) and psychosomatic (SCL-90) symptoms; bone markers procollagen-type-1-N-propeptide (P1NP), osteocalcin (OC) and crosslaps (CTx) were analyzed. Multiple linear regressions assessed associations of depressive and psychosomatic symptoms with bone markers and moderating effects of depressive and psychosomatic symptoms on the PHYA-bone marker relationship; Mediation analyses were conducted with the PROCESS macro. All analyses were conducted in IBM SPSS (v31.0; p < 0.05).

Results

Data from n = 44 depressed participants were eligible for analysis. Significant associations of BDI-II and SCL-90 with P1NP and OC were detected. A significant moderation of SCL-90 on the relationship of PHYA with P1NP (p < 0.05), but no mediation effect of BDI-II or SCL90 on bone markers was detected.

Conclusions

Depressive and psychosomatic symptoms influence and may potentially moderate the relationship between PHYA and bone markers, which should be considered in further studies and therapeutic planning.

目的体育活动对骨骼健康有积极影响，但这种关系可能受到精神障碍的影响。目的：(1)评估精神障碍是否影响骨标志物；(2)PHYA与骨标志物的关系是否受到精神障碍的影响。方法二次资料分析纵向depreha研究(德国，18个月，n = 208, 18-65岁，ICD-10 F32.x-F33。X，收集于2015-2017年)。基线数据：社会人口学、PHYA、抑郁（BDI-II）和心身（SCL-90）症状；分析骨标志物前胶原-1- n型前肽（P1NP）、骨钙素（OC）和交叉膜（CTx）。多元线性回归评估抑郁和心身症状与骨标志物的关联，以及抑郁和心身症状对phya -骨标志物关系的调节作用；中介分析是用PROCESS宏进行的。所有分析均在IBM SPSS （v31.0; p < 0.05）中进行。结果n = 44名抑郁症参与者的数据符合分析条件。BDI-II和SCL-90与P1NP和OC有显著相关性。SCL-90对PHYA与P1NP的关系有显著调节作用（p < 0.05），但BDI-II或SCL-90对骨标志物没有中介作用。结论抑郁和心身症状影响并可能调节PHYA与骨标志物之间的关系，应在进一步的研究和治疗计划中加以考虑。

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Neighborhood spikes in drug and alcohol overdoses and subsequent suicide: A serial cross-sectional study of California ZIP codes 社区毒品和酒精过量和随后的自杀激增：加州邮政编码的一系列横断面研究

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Preventive Medicine Reports

Pub Date : 2026-01-01 DOI: 10.1016/j.pmedr.2025.103358

Veronica A. Pear , Sonia L. Robinson , Julia P. Schleimer , Garen J. Wintemute , Aimée Moulin

Objective

The overdose crisis potentially increases risk factors for suicide while decreasing resources available to help those in need. This study sought to determine whether acute increases in drug or alcohol overdoses increase suicide rates.

Methods

This serial cross-sectional study used comprehensive emergency department, hospital discharge, and mortality data for ZIP-code-months in California, March 2010–December 2018 (n = 163,240). Overdose spikes were defined as ZIP-code-months with rates >2 standard deviations above expected. We used confounder-adjusted Bayesian Poisson space-time misalignment models to estimate whether overdose spikes, lagged 0–6 months, were associated with the rate of suicide (overall and by firearm involvement).

Results

Overdose spikes were identified in 6728 (4.1%) ZIP-code-months. In unadjusted models, overdose spikes were associated with same-month increases in suicide (IRR: 1.07, 95% CI: 1.02, 1.14) and non-firearm suicide (IRR: 1.09, 95% CI: 1.02, 1.17). The latter association persisted in adjusted models (IRR: 1.08, 95% CI: 1.00, 1.15), which also showed reduced firearm suicide four months following a spike (IRR: 0.90, 95% CI: 0.82, 0.99). No other associations were significant.

Conclusions

We did not find robust evidence of an association between spikes in ZIP-code-level overdoses and suicide. However, associations in unadjusted models point to a potential syndemic of overdose and suicide.

目的药物过量危机潜在地增加了自杀的危险因素，同时减少了可用于帮助有需要的人的资源。这项研究试图确定药物或酒精过量的急性增加是否会增加自杀率。方法：本系列横断面研究使用2010年3月至2018年12月加利福尼亚州邮政编码月份的急诊科、出院和死亡率综合数据（n = 163,240）。过量峰值被定义为邮政编码月，其比率高于预期2个标准差。我们使用混杂因素调整的贝叶斯泊松时空失调模型来估计过量峰值（滞后0-6个月）是否与自杀率（总体和枪支参与）相关。结果在6728个邮码月（4.1%）内发现过剂量峰。在未调整的模型中，过量峰值与当月自杀（IRR: 1.07, 95% CI: 1.02, 1.14）和非枪支自杀（IRR: 1.09, 95% CI: 1.02, 1.17）的增加有关。后一种关联在调整后的模型中持续存在（IRR: 1.08, 95% CI: 1.00, 1.15），也显示在高峰后四个月枪支自杀减少（IRR: 0.90, 95% CI: 0.82, 0.99）。其他关联不显著。结论：我们没有发现强有力的证据表明邮政编码水平的过量用药与自杀之间存在关联。然而，未经调整的模型中的关联指向了过量服用和自杀的潜在综合征。

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Corrigendum to “Cancer beliefs, risk perceptions, and health protective behaviors among people living with diabetes in the United States: Results from the Health Information National Trends Survey” [Prev. Med. Rep. 57 (2025) 103206] “美国糖尿病患者的癌症信念、风险认知和健康保护行为：来自健康信息国家趋势调查的结果”的勘误表。众议员57 (2025)103206]

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Preventive Medicine Reports

Pub Date : 2026-01-01 DOI: 10.1016/j.pmedr.2025.103359

Jiamin Hu , Young-Rock Hong , Daniela Rivero-Mendoza , William T. Donahoo , Naykky Singh Ospina , Stephanie A. Staras , Elizabeth Shenkman , Rahma S. Mkuu

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IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Preventive Medicine Reports

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