Pub Date : 2025-12-01DOI: 10.1016/j.nmni.2025.101637
Chiranjib Chakraborty , Manojit Bhattacharya , Arpita Das , Rao Zahid Abbas , Priyanka Choudhary , Om Prakash Choudhary
{"title":"Current status of H5N1 influenza vaccines against clade 2.3.4.4b of H5N1","authors":"Chiranjib Chakraborty , Manojit Bhattacharya , Arpita Das , Rao Zahid Abbas , Priyanka Choudhary , Om Prakash Choudhary","doi":"10.1016/j.nmni.2025.101637","DOIUrl":"10.1016/j.nmni.2025.101637","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101637"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.nmni.2025.101678
Ala'a B. Al-Tammemi , Tareq L. Mukattash
{"title":"Ethiopia's first-ever Marburg virus disease outbreak: Implications for health security in Jordan in the context of labor migration","authors":"Ala'a B. Al-Tammemi , Tareq L. Mukattash","doi":"10.1016/j.nmni.2025.101678","DOIUrl":"10.1016/j.nmni.2025.101678","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101678"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.nmni.2025.101679
Michela Bulfoni , Carlo Tascini , Paola Della Siega , Corrado Pipan , Silvio Brusaferro , Paolo Gaibani
Not applicable.
不适用。
{"title":"Case report of a bloodstream infection due by Salmonella strathcona ST2559 in northeast Italy, 2025","authors":"Michela Bulfoni , Carlo Tascini , Paola Della Siega , Corrado Pipan , Silvio Brusaferro , Paolo Gaibani","doi":"10.1016/j.nmni.2025.101679","DOIUrl":"10.1016/j.nmni.2025.101679","url":null,"abstract":"<div><div>Not applicable.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101679"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1016/j.nmni.2025.101670
Jaime David Acosta-España , Matheo Morales-Gualotuña , Julián Pazmiño-Villaseñor , Ivan Dueñas-Espín
Background
Dengue and malaria remain critical vector-borne threats in Latin America, yet mortality surveillance at subnational levels is sparse. Ecuador, a country with diverse ecological zones and shifting transmission dynamics, lacks standardized hospital-based mortality indicators to guide targeted interventions.
Objective
To analyze age-standardized hospital mortality rates for dengue and malaria across Ecuador's 24 provinces from 2015 to 2023, identifying geographic disparities, temporal trends, and surveillance gaps.
Methods
We conducted a cross-sectional ecological study using anonymized hospital discharge data from the National Institute of Statistics and Censuses (INEC). Fatal dengue and malaria cases were identified using ICD-10 codes and stratified by year, age groups, and province. Standardized mortality rates per million inhabitants were calculated using population projections, and geographic and temporal patterns were visualized through heat maps and time-series plots.
Results
Dengue accounted for 125 hospital deaths, with mortality concentrated in Amazonian and coastal provinces. Malaria, though markedly less frequent, resulted in five adult deaths (3 in 2019, 1 in 2021, and 1 in 2023), with Plasmodium falciparum predominating. The highest malaria mortality rate occurred in Napo (16.3 per million in 2021), underscoring the fragility of elimination gains. Both diseases revealed fragmented mortality patterns, with isolated spikes and persistent underreporting in endemic zones.
Conclusion
Hospital-based mortality data expose critical gaps in Ecuador's arboviral and Plasmodium spp surveillance. While dengue shows episodic lethality across endemic provinces, malaria's sporadic fatality signals in urban, non-endemic regions highlight the need for sustained clinical vigilance and integrated mortality monitoring.
{"title":"Dengue and malaria mortality in Ecuador: A population analysis of hospital deaths across 24 provinces, 2015–2023","authors":"Jaime David Acosta-España , Matheo Morales-Gualotuña , Julián Pazmiño-Villaseñor , Ivan Dueñas-Espín","doi":"10.1016/j.nmni.2025.101670","DOIUrl":"10.1016/j.nmni.2025.101670","url":null,"abstract":"<div><h3>Background</h3><div>Dengue and malaria remain critical vector-borne threats in Latin America, yet mortality surveillance at subnational levels is sparse. Ecuador, a country with diverse ecological zones and shifting transmission dynamics, lacks standardized hospital-based mortality indicators to guide targeted interventions.</div></div><div><h3>Objective</h3><div>To analyze age-standardized hospital mortality rates for dengue and malaria across Ecuador's 24 provinces from 2015 to 2023, identifying geographic disparities, temporal trends, and surveillance gaps.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional ecological study using anonymized hospital discharge data from the National Institute of Statistics and Censuses (INEC). Fatal dengue and malaria cases were identified using ICD-10 codes and stratified by year, age groups, and province. Standardized mortality rates per million inhabitants were calculated using population projections, and geographic and temporal patterns were visualized through heat maps and time-series plots.</div></div><div><h3>Results</h3><div>Dengue accounted for 125 hospital deaths, with mortality concentrated in Amazonian and coastal provinces. Malaria, though markedly less frequent, resulted in five adult deaths (3 in 2019, 1 in 2021, and 1 in 2023), with <em>Plasmodium falciparum</em> predominating. The highest malaria mortality rate occurred in Napo (16.3 per million in 2021), underscoring the fragility of elimination gains. Both diseases revealed fragmented mortality patterns, with isolated spikes and persistent underreporting in endemic zones.</div></div><div><h3>Conclusion</h3><div>Hospital-based mortality data expose critical gaps in Ecuador's arboviral and <em>Plasmodium spp</em> surveillance. While dengue shows episodic lethality across endemic provinces, malaria's sporadic fatality signals in urban, non-endemic regions highlight the need for sustained clinical vigilance and integrated mortality monitoring.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"69 ","pages":"Article 101670"},"PeriodicalIF":5.4,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.nmni.2025.101669
Luria L. Founou , Raspail C. Founou
{"title":"Neonatal sepsis in Cameroon: A call for a national registry and surveillance to bridge data and action gaps","authors":"Luria L. Founou , Raspail C. Founou","doi":"10.1016/j.nmni.2025.101669","DOIUrl":"10.1016/j.nmni.2025.101669","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101669"},"PeriodicalIF":5.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.nmni.2025.101668
Qiuyu Zhang , Ge Zhang , Yongbin Zhai , Qi Zhao , Yaru Feng , Maraba Rawaydul , Yuyu Zhang , Xiaolong Jiao , Yang Zhang , Yuefeng Chu , Jian Xu , Duoliang Ran , Bin Li
In April 2023, outbreaks of a novel oral disease were observed in Bactrian camels in Altay Prefecture, Xinjiang, China. To clarify the etiology and epidemiology, we surveyed 1863 camels from 12 farms across three major camel-producing counties. A total of 311 camels (16.7 %) exhibited characteristic lesions, with significantly higher incidence in adults (18.1 %) than juveniles (9.7 %) (p < 0.05). Tissue samples from 12 clinically affected camels were subjected to PCR testing for multiple poxviruses. Only Camel Contagious Ecthyma Virus (CCEV) was detected, and sequencing of the B2L gene confirmed its identity. Phylogenetic analysis revealed that Xinjiang isolates shared >98 % nucleotide homology with strains from Saudi Arabia and Sudan, with no variation among the 12 local sequences. Histopathology showed epidermal necrosis, hyperplasia, and intracytoplasmic inclusion bodies, consistent with parapoxvirus infection, and electron microscopy revealed typical poxvirus morphology. These findings document the first confirmed detection and molecular characterization of CCEV in camels in China, highlighting its potential impact on the camel industry and the need for further investigation of its epidemiology and zoonotic risk.
{"title":"First identification of camel Contagious Ecthyma Virus in camels from Altay, Xinjiang, China","authors":"Qiuyu Zhang , Ge Zhang , Yongbin Zhai , Qi Zhao , Yaru Feng , Maraba Rawaydul , Yuyu Zhang , Xiaolong Jiao , Yang Zhang , Yuefeng Chu , Jian Xu , Duoliang Ran , Bin Li","doi":"10.1016/j.nmni.2025.101668","DOIUrl":"10.1016/j.nmni.2025.101668","url":null,"abstract":"<div><div>In April 2023, outbreaks of a novel oral disease were observed in Bactrian camels in Altay Prefecture, Xinjiang, China. To clarify the etiology and epidemiology, we surveyed 1863 camels from 12 farms across three major camel-producing counties. A total of 311 camels (16.7 %) exhibited characteristic lesions, with significantly higher incidence in adults (18.1 %) than juveniles (9.7 %) (<em>p</em> < 0.05). Tissue samples from 12 clinically affected camels were subjected to PCR testing for multiple poxviruses. Only <em>Camel Contagious Ecthyma Virus</em> (CCEV) was detected, and sequencing of the B2L gene confirmed its identity. Phylogenetic analysis revealed that Xinjiang isolates shared >98 % nucleotide homology with strains from Saudi Arabia and Sudan, with no variation among the 12 local sequences. Histopathology showed epidermal necrosis, hyperplasia, and intracytoplasmic inclusion bodies, consistent with parapoxvirus infection, and electron microscopy revealed typical poxvirus morphology. These findings document the first confirmed detection and molecular characterization of CCEV in camels in China, highlighting its potential impact on the camel industry and the need for further investigation of its epidemiology and zoonotic risk.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101668"},"PeriodicalIF":5.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1016/j.nmni.2025.101672
Blessed T. Mukuhlani
Dengue virus (DENV), a globally prevalent flavivirus, is a growing threat in regions where HIV is endemic. The co-endemicity of HIV and dengue poses overlapping clinical challenges, particularly in low-resource settings where diagnostic capacity is limited. This review examines the epidemiological overlap, immunological interactions, and diagnostic difficulties associated with DENV infection in people living with HIV (PLWH). Seroprevalence studies reveal high rates of dengue exposure among PLWH in sub-Saharan Africa, Latin America, and Southeast Asia, with increasing evidence of autochthonous transmission in non-endemic regions. Immunologically, coinfection is characterized by altered platelet function, suppressed chemokine secretion, and dysregulated T cell activation. Molecules such as CLEC5A and CD300a play key roles in the immune modulation seen in coinfected hosts. Although clinical presentations vary from mild to severe, atypical manifestations including encephalitis and hepatic dysfunction have been observed. Diagnostic confusion with acute HIV syndrome or other febrile illnesses remains a major concern. Innovations such as CRISPR-based detection systems and graphene biosensors hold promise for field-deployable diagnostics. Mathematical modeling supports integrated control strategies, and novel DENV-derived peptides like pepRF1 show potential as dual-acting therapeutics. As climate change facilitates the spread of Aedes vectors, dengue's expansion into new territories highlights the urgency of integrating arboviral surveillance with HIV care systems. This review underscores the need for enhanced diagnostics, better therapeutic options, and longitudinal research on DENV pathogenesis in immunocompromised populations.
{"title":"Pathogenesis and seroprevalence of dengue virus in HIV-endemic regions: A global perspective","authors":"Blessed T. Mukuhlani","doi":"10.1016/j.nmni.2025.101672","DOIUrl":"10.1016/j.nmni.2025.101672","url":null,"abstract":"<div><div>Dengue virus (DENV), a globally prevalent flavivirus, is a growing threat in regions where HIV is endemic. The co-endemicity of HIV and dengue poses overlapping clinical challenges, particularly in low-resource settings where diagnostic capacity is limited. This review examines the epidemiological overlap, immunological interactions, and diagnostic difficulties associated with DENV infection in people living with HIV (PLWH). Seroprevalence studies reveal high rates of dengue exposure among PLWH in sub-Saharan Africa, Latin America, and Southeast Asia, with increasing evidence of autochthonous transmission in non-endemic regions. Immunologically, coinfection is characterized by altered platelet function, suppressed chemokine secretion, and dysregulated T cell activation. Molecules such as CLEC5A and CD300a play key roles in the immune modulation seen in coinfected hosts. Although clinical presentations vary from mild to severe, atypical manifestations including encephalitis and hepatic dysfunction have been observed. Diagnostic confusion with acute HIV syndrome or other febrile illnesses remains a major concern. Innovations such as CRISPR-based detection systems and graphene biosensors hold promise for field-deployable diagnostics. Mathematical modeling supports integrated control strategies, and novel DENV-derived peptides like pepRF1 show potential as dual-acting therapeutics. As climate change facilitates the spread of Aedes vectors, dengue's expansion into new territories highlights the urgency of integrating arboviral surveillance with HIV care systems. This review underscores the need for enhanced diagnostics, better therapeutic options, and longitudinal research on DENV pathogenesis in immunocompromised populations.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101672"},"PeriodicalIF":5.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.nmni.2025.101667
D.A.J. Agokeng , G.S.S. Njateng , S. Dabou , K. Diongue , K.B.D. Agokeng , S. Ranque
Tinea capitis (TC), commonly known as scalp ringworm, is a dermatophytosis affecting the scalp. It represents a significant public health concern worldwide, particularly in Africa. However, epidemiological data on this infection remain limited in Cameroon. This study aimed to assess the prevalence and risk factors of TC among school-children in four regions of Cameroun. A cross-sectional study was carried out from April to June 2023 including pupils aged 5–14. First, a standardized questionnaire was administered to the participants to collect sociodemographic data. Then, the children were examined and TC lesion samples were collected and cultured onto Sabouraud Chloramphenicol-Gentamicin Agar. The cultured dermatophytes were identified based on their morphological features and with MALDI-TOF mass spectrometry.
A total of 459 children were included, of whom 118 (25.7 %) presented with TC lesions. Traditional hair braiding (OR = 0.24, 95 %CI: 0.06–0.90), and sleeping alone (OR = 0.49, 95 %CI: 0.26–0.91) were associated with a decreased risk of TC in multivariate logistic regression analysis. In contrast, male sex (OR = 3.15, 95 %CI [1.63–6.06]), hairdressing at home (OR = 2.39, 95 %CI [1.45–3.93]), and ringworm in siblings (OR = 2.79, 95 %CI [1.73–4.50]) were associated with an increased risk of TC. These results emphasise the importance of raising awareness and providing education on hygiene and hairstyling practices. Further efforts are needed strengthen health infrastructure, and implement targeted public health programmes to better control this disease in Cameroon.
{"title":"Prevalence and risk factors of tinea capitis in primary school children across four regions of Cameroon","authors":"D.A.J. Agokeng , G.S.S. Njateng , S. Dabou , K. Diongue , K.B.D. Agokeng , S. Ranque","doi":"10.1016/j.nmni.2025.101667","DOIUrl":"10.1016/j.nmni.2025.101667","url":null,"abstract":"<div><div>Tinea capitis (TC), commonly known as scalp ringworm, is a dermatophytosis affecting the scalp. It represents a significant public health concern worldwide, particularly in Africa. However, epidemiological data on this infection remain limited in Cameroon. This study aimed to assess the prevalence and risk factors of TC among school-children in four regions of Cameroun. A cross-sectional study was carried out from April to June 2023 including pupils aged 5–14. First, a standardized questionnaire was administered to the participants to collect sociodemographic data. Then, the children were examined and TC lesion samples were collected and cultured onto Sabouraud Chloramphenicol-Gentamicin Agar. The cultured dermatophytes were identified based on their morphological features and with MALDI-TOF mass spectrometry.</div><div>A total of 459 children were included, of whom 118 (25.7 %) presented with TC lesions. Traditional hair braiding (OR = 0.24, 95 %CI: 0.06–0.90), and sleeping alone (OR = 0.49, 95 %CI: 0.26–0.91) were associated with a decreased risk of TC in multivariate logistic regression analysis. In contrast, male sex (OR = 3.15, 95 %CI [1.63–6.06]), hairdressing at home (OR = 2.39, 95 %CI [1.45–3.93]), and ringworm in siblings (OR = 2.79, 95 %CI [1.73–4.50]) were associated with an increased risk of TC. These results emphasise the importance of raising awareness and providing education on hygiene and hairstyling practices. Further efforts are needed strengthen health infrastructure, and implement targeted public health programmes to better control this disease in Cameroon.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101667"},"PeriodicalIF":5.4,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.nmni.2025.101665
Marie Tré-Hardy , Sophie Collignon , Andrea Della Vecchia , Mikael Leys , Roberto Cupaiolo , Ingrid Beukinga , Denis Piérard , Florence Crombé , Laurent Blairon
Background
Meningitis caused by Escherichia coli K1 occurs only in specific cases: in neonates or in adults following trauma or in a nosocomial context resulting from procedures that create a direct entry point, such as neurosurgical procedures. Community-acquired cases in adults are rare, and those secondary to septic arthritis are even rarer.
In this article, an exceptionally uncommon case of community-acquired meningitis due to Escherichia coli O25:K1:H4 (sequence type 95) with concomitant septic arthritis at the L4/L5 level is described, emphasizing the diagnostic process, which was aided by detailed microbiological documentation.
Case presentation
A 73-year-old man with a history of hypertension, alcohol use, and atrial fibrillation presented with acute lower back pain, confusion, persistent vomiting, headache, lethargy, and low-grade fever (37.9 °C). He also demonstrated a positive Lasegue's sign and had elevated inflammatory markers without an obvious infectious source. The patient experienced a favorable outcome with no neurological sequelae after receiving treatment with ceftriaxone 2g every 12 h, initiated from the first day of arrival at the emergency department.
Conclusions
Challenging but achievable, the diagnosis was made by integrating clinical history, microbiological findings, and radiological results. In particular, multiplex PCR played a crucial role in the prompt diagnosis of Escherichia coli K1 meningitis, while also influencing the management and outcome of the patient.
{"title":"Escherichia coli K1 meningitis concomitant with septic arthritis in an adult: a rare case and mini-review of the literature","authors":"Marie Tré-Hardy , Sophie Collignon , Andrea Della Vecchia , Mikael Leys , Roberto Cupaiolo , Ingrid Beukinga , Denis Piérard , Florence Crombé , Laurent Blairon","doi":"10.1016/j.nmni.2025.101665","DOIUrl":"10.1016/j.nmni.2025.101665","url":null,"abstract":"<div><h3>Background</h3><div>Meningitis caused by <em>Escherichia coli</em> K1 occurs only in specific cases: in neonates or in adults following trauma or in a nosocomial context resulting from procedures that create a direct entry point, such as neurosurgical procedures. Community-acquired cases in adults are rare, and those secondary to septic arthritis are even rarer.</div><div>In this article, an exceptionally uncommon case of community-acquired meningitis due to <em>Escherichia coli</em> O25:K1:H4 (sequence type 95) with concomitant septic arthritis at the L4/L5 level is described, emphasizing the diagnostic process, which was aided by detailed microbiological documentation.</div></div><div><h3>Case presentation</h3><div>A 73-year-old man with a history of hypertension, alcohol use, and atrial fibrillation presented with acute lower back pain, confusion, persistent vomiting, headache, lethargy, and low-grade fever (37.9 °C). He also demonstrated a positive Lasegue's sign and had elevated inflammatory markers without an obvious infectious source. The patient experienced a favorable outcome with no neurological sequelae after receiving treatment with ceftriaxone 2g every 12 h, initiated from the first day of arrival at the emergency department.</div></div><div><h3>Conclusions</h3><div>Challenging but achievable, the diagnosis was made by integrating clinical history, microbiological findings, and radiological results. In particular, multiplex PCR played a crucial role in the prompt diagnosis of <em>Escherichia coli</em> K1 meningitis, while also influencing the management and outcome of the patient.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101665"},"PeriodicalIF":5.4,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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