New Microbes and New Infections最新文献

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Investigation of SEN virus prevalence in hemophilia patients 血友病患者 SEN 病毒流行情况调查

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-27 DOI: 10.1016/j.nmni.2024.101470

Davod Javanmard , Motahareh Mahi-Birjand , Effat Alemzadeh , Mahdie Mohammadi , Masood Ziaee

Background

Hemophilia and transfusion-dependent patients are at high risk of a wide range of blood-borne agents. Among these, SEN virus (SENV) stands out as a significant concern due to its association with transfusion-induced non-A to non-E hepatitis. This study, therefore, aimed to investigate the prevalence of this virus in hemophilia patients, focusing on potential complications and risk factors.

Method

This was a cross-sectional study conducted in a hemophilia center in the east of Iran. Blood samples were taken from patients and healthy people, and demographic and clinical information was collected. The sera samples were then subjected to DNA extraction. PCR-based methods detected SENV and its genotype, and then phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS22 software.

Results

The mean age of patients and the healthy group was 26.18 ± 14.97 and 41.69 ± 14.05, respectively. Among the patient and healthy groups, 94.5 % and 36.4 % were male, and the rest were female, respectively. Most of the participants in the patient group had hemophilia type A (85.5 %), then type B (7.3 %), VWD type (3.6 %), and F and plt type (1.8 %) were in the next categories. SENV-DNA was detected in 58.2 % of patients and 20 % of healthy groups (P-value: 0.00). Among these, H and D genotypes were found in 35 % and 23.7 % of patients and 12.7 % and 7.3 % of healthy groups, respectively. The prevalence of the virus was significantly related to minor elevation of AST and was higher in hemophilia type A (63.8 %) and severe type of disease (63.2 %).

Conclusion

This study underscore the significant prevalence of the SENV virus in hemophilia patients, a particularly noteworthy finding compared to the healthy population. With the limited information available about this virus, our findings highlight the importance of continuous monitoring and follow-up of high-risk groups in relation to blood-borne pathogens, providing reassurance about the ongoing efforts in the field.

背景血友病和输血依赖型患者面临多种血液传播病原体的高风险。其中，SEN 病毒（SENV）因其与输血引起的非 A 型至非 E 型肝炎有关而备受关注。因此，本研究旨在调查该病毒在血友病患者中的流行情况，重点关注潜在的并发症和风险因素。研究人员采集了患者和健康人的血样，并收集了人口统计学和临床信息。然后对血清样本进行 DNA 提取。基于 PCR 的方法检测 SENV 及其基因型，然后进行系统发育分析。结果患者和健康组的平均年龄分别为（26.18±14.97）岁和（41.69±14.05）岁。在患者组和健康组中，男性和女性分别占 94.5% 和 36.4%。患者组中大多数人患有 A 型血友病（85.5%），其次是 B 型（7.3%）、VWD 型（3.6%）、F 型和 plt 型（1.8%）。在 58.2% 的患者和 20% 的健康人群中检测到 SENV-DNA（P 值：0.00）。其中，H 和 D 基因型分别在 35% 和 23.7% 的患者以及 12.7% 和 7.3% 的健康人群中发现。该病毒的流行与谷草转氨酶的轻微升高密切相关，在 A 型血友病（63.8%）和重症血友病（63.2%）中的流行率更高。由于有关该病毒的信息有限，我们的研究结果凸显了对血液传播病原体高危人群进行持续监测和随访的重要性，为该领域的持续努力提供了保证。

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引用次数: 0

Staphylococcus nepalensis infecting a companion animal: Genomic insights from an emerging multidrug-resistant pathogen 感染伴侣动物的肾葡萄球菌：从一种新出现的耐多药病原体的基因组学角度看问题

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-27 DOI: 10.1016/j.nmni.2024.101472

Luciana Sartori, Andrey G. Sacramento, Fábio P. Sellera, João Pedro Rueda Furlan, Fernanda B. Barbosa, Fernanda Esposito, Nilton Lincopan, Terezinha Knöbl

引用次数: 0

SARS-CoV-2 infection of domestic animals and their role in evolution and emergence of variants of concern 家畜感染 SARS-CoV-2 及其在演变和出现令人担忧的变种方面的作用

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-25 DOI: 10.1016/j.nmni.2024.101468

Olajumoke Olufunmilayo Joseph , Samuel Olatunde Dahunsi , Anthony Okoh

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for COVID-19 pandemic, is a zoonotic RNA virus that has been reported in animals, including domestic animals. Due to the growing concern of health threat that could arise from active transmission of SARS-CoV-2 between pet owners and their pets, there is need to monitoring the emergence of a highly pathogenic strain of SARS-CoV-2 that is capable of transboundary infection, or a serious outbreak among human populations.

Methods

We carried out a search in English, on PubMed and NCBI (National Center for Biotechnology Information) SARS-CoV-2 resources for relevant journals and nucleotide sequence data, that were published between 2019 and 2023. The CoVsurver mutations application on GISAID webpage was used to analyse mutation, nucleotide sequence alignment was carried out using MAFFT (Multiple Alignment using Fast Fourier Transform) version 7 and maximum likelihood tree was constructed by bootstrapping with 1000 replicates on MEGA 11 software.

Results

A total of 47 mutations at the Spike gene region were identified, and mutation D614 was the most observed mutation. Nucleotide sequences of isolates from domestic animals had high sequence identity with Wuhan-Hu-1 reference sequence and the representative sequences of previously circulating VOCs from humans.

Conclusion

This reveals that there is spill over of previously circulating variants of concern (VOC) to household pets from their infected owners. Hence, there is an urgent need for more intense surveillance to be carried out globally to monitor evolution of SARS-CoV-2 coronaviruses as a result of human – pet association.

背景造成 COVID-19 大流行的严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）是一种人畜共患的 RNA 病毒，在动物（包括家畜）中也有报道。由于人们越来越担心 SARS-CoV-2 在宠物主人及其宠物之间的主动传播可能会对健康造成威胁，因此有必要监测 SARS-CoV-2 高致病性毒株的出现，这种毒株可能会造成跨境感染，也可能会在人类中爆发严重疫情。使用GISAID网页上的CoVsurver突变应用软件分析突变，使用MAFFT（Multiple Alignment using Fast Fourier Transform）版本7进行核苷酸序列比对，并在MEGA 11软件上通过1000次重复的引导构建最大似然树。家养动物分离物的核苷酸序列与武汉-Hu-1 参考序列和以前在人类中流行的 VOCs 的代表序列具有很高的序列同一性。因此，急需在全球范围内开展更密集的监测，以监控 SARS-CoV-2 冠状病毒因人类与宠物之间的关联而发生的演变。

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引用次数: 0

Global Mpox outbreak: Are we prepared for emerging strains? 全球爆发麻风腮疫情：我们对新出现的菌株做好准备了吗？

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-23 DOI: 10.1016/j.nmni.2024.101466

Ranjit Sah , Shriyansh Srivastava , Rachana Mehta, Sachin Kumar, Sanjit Sah, Aroop Mohanty, Jack Feehan, Jaffar A. Al-Tawfiq , Vasso Apostolopoulos

引用次数: 0

Oropouche fever rears its head in Cuba: What lies beneath the surface? 奥罗普切热在古巴抬头：表面之下隐藏着什么？

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-22 DOI: 10.1016/j.nmni.2024.101460

Angel A. Escobedo, Alfonso J. Rodríguez-Morales

引用次数: 0

Integrating wildlife within national action plan for antimicrobial resistance 将野生动物纳入国家抗菌药耐药性行动计划

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-22 DOI: 10.1016/j.nmni.2024.101467

AbdulRahman A. Saied

引用次数: 0

Current challenges for controlling and eliminating malaria in Iran 伊朗目前在控制和消除疟疾方面面临的挑战

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-22 DOI: 10.1016/j.nmni.2024.101464

Ismaeil Alizadeh, Mohammad Mehdi Sedaghat

引用次数: 0

Climate change and expansion of vector-borne diseases in Japan: A public health challenge 气候变化与日本病媒传染病的蔓延：公共卫生挑战

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-22 DOI: 10.1016/j.nmni.2024.101462

Keita Wagatsuma

引用次数: 0

Co-infections of SARS-CoV-2 with respiratory syncytial virus and human influenza A in patients with symptoms of COVID-19 in Ghana: A retrospective study 加纳出现 COVID-19 症状的患者同时感染 SARS-CoV-2 与呼吸道合胞病毒和人类甲型流感：回顾性研究

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-21 DOI: 10.1016/j.nmni.2024.101463

Kwabena Obeng Duedu , Jones Gyamfi , Reuben Ayivor-Djanie , Godknows Afenya , Isaac Buertey Agbuglah , Hubert Kwame Agbogli , Priscilla Essandoh , Seraphine Kugbemanya , Theophilus Koku Adiku

Background

During the COVID-19 pandemic the aetiology of respiratory illnesses were narrowed to SARS-CoV-2. This prevented diagnosis of other pathogens and patients were not notified of the accurate diagnosis of their illnesses when SARS-CoV-2 was absent. It is therefore important to look back and determine what else was present but was missed.

Objective

This retrospective study sought to gain insights into prevalence of respiratory syncytial virus (RSV) and influenza A alongside SARS-CoV-2 in patients who reported with clinical symptoms of respiratory illnesses.

Methods

Samples from patients who had reported of respiratory symptoms were selected at random from a pool. RNA was extracted and RT-PCR was performed for SARS-CoV-2, RSV and Influenza A in parallel. Data on the clinical symptoms was extracted from case-base forms and analysed.

Results

Of the 400 symptomatic samples tested, prevalence of SARS-CoV-2, influenza A and RSV was 20.3 %, 2.0 % and 0.5 % respectively. Only one sample tested positive for SARS-CoV-2 and influenza A. About 77 % of the symptomatic cases did not test positive for any of the three agents. Cough (79 %) was the most common symptom followed by fever and chills, headache, sore throat and runny nose.

Conclusion

The large proportion of symptomatic cases that tested negative for all three respiratory viruses raises a flag and a need for more investigations into the actual burden of respiratory aetiologic agents during the pandemic. With the low levels of co-infections, parallel testing may not be needed however, a strong case for multiplex tests for respiratory agents exists.

背景在 COVID-19 大流行期间，呼吸道疾病的病原体被缩小到 SARS-CoV-2。这就妨碍了对其他病原体的诊断，当 SARS-CoV-2 不存在时，患者并没有被告知其疾病的准确诊断。本回顾性研究旨在了解在报告有呼吸道疾病临床症状的患者中，除 SARS-CoV-2 外，呼吸道合胞病毒 (RSV) 和甲型流感的流行情况。提取 RNA 并同时对 SARS-CoV-2、RSV 和甲型流感进行 RT-PCR 检测。结果在检测的 400 份有症状的样本中，SARS-CoV-2、甲型流感和 RSV 的流行率分别为 20.3%、2.0% 和 0.5%。只有一个样本对 SARS-CoV-2 和甲型流感检测呈阳性。咳嗽（79%）是最常见的症状，其次是发烧和发冷、头痛、喉咙痛和流鼻涕。由于合并感染率较低，因此可能不需要进行平行检测，但有充分理由对呼吸道病原体进行多重检测。

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引用次数: 0

Increasing spillover of highly pathogenic avian influenza A (H5N1) virus to mammals 高致病性甲型禽流感（H5N1）病毒越来越多地向哺乳动物扩散

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-19 DOI: 10.1016/j.nmni.2024.101459

Shao-Lun Zhai, Sheng-Nan Chen, Jieshi Yu, Bo Liu, Handuo Jia

引用次数: 0

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