New Microbes and New Infections最新文献

{"title":"Acinetobacter towneri harbouring blaNDM-1 and blaOXA-58: genomic characterization of the first human isolate from Brazil","authors":"Daiana Cristina Silva Rodrigues , Bruna Ribeiro Sued-Karam , Melise Chaves Silveira , Orlando Carlos da Conceição-Neto , Bruno Rocha Pribul , Ana Paula D'Alincourt Carvalho-Assef , Cláudio Marcos Rocha-de-Souza","doi":"10.1016/j.nmni.2025.101652","DOIUrl":"10.1016/j.nmni.2025.101652","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101652"},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital wastewater microbiome & resistome: An overlooked one health crisis driving superbugs in low- and middle-income countries (LMICs)","authors":"Hemayet Hossain , Shihab Ahmed","doi":"10.1016/j.nmni.2025.101653","DOIUrl":"10.1016/j.nmni.2025.101653","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101653"},"PeriodicalIF":5.4,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution and the potential for human-to-human transmission of severe fever with thrombocytopenia syndrome virus in low transmission settings in China","authors":"Yin Wang ,&nbsp;Yao Huang ,&nbsp;Jie Liang ,&nbsp;Qiumei Li ,&nbsp;Liguo Zhu ,&nbsp;Shuyi Liang ,&nbsp;Zhifeng Li ,&nbsp;Chaojie Xu ,&nbsp;Jianli Hu ,&nbsp;Yun Gu ,&nbsp;Yuyang Ge ,&nbsp;Xiuling Zhang ,&nbsp;Zhengya Wei ,&nbsp;Luojing Zhou ,&nbsp;Guangyu Lu","doi":"10.1016/j.nmni.2025.101650","DOIUrl":"10.1016/j.nmni.2025.101650","url":null,"abstract":"<div><h3>Objective</h3><div>Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease with substantial mortality, was first reported in China in 2009 and subsequently became endemic to South Korea, Japan, Vietnam, and the United Arab Emirates. Despite growing concerns about its transmission dynamics, the potential for human-to-human transmission through close physical contact remains inadequately explored in the literature.</div></div><div><h3>Methods</h3><div>We conducted comprehensive epidemiological investigations of the initial cases of SFTS. In these investigations, real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) was used to analyze blood samples, followed by whole-genome sequencing (WGS) for phylogenetic tree construction.</div></div><div><h3>Results</h3><div>Our analyses identified one potential index case (Case A) and one confirmed case (Case B), both of which tested positive for SFTS virus (SFTSV) nucleic acid. Notably, we observed an 8.65 % positive rate for SFTSV nucleic acid in <em>Haemaphysalis longicornis</em> ticks near Case A's residence. Additionally, the only potential exposure route for Case B appeared to be close physical contact with Case A. Genetic sequencing indicated high nucleotide homology (ranging from 99.63 % to 99.91 %) between the SFTSV strains isolated from both cases.</div></div><div><h3>Conclusions</h3><div>Collectively, our study further demonstrated that close intimate contact may serve as a significant mode of SFTSV transmission among humans. This finding underscores the importance of enhancing awareness and implementing preventive measures among patients, healthcare providers, and relevant public health personnel regarding the human-to-human transmission of SFTS, contributing to more targeted public health strategies in SFTS-endemic regions, particularly in areas with low endemicity levels.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101650"},"PeriodicalIF":5.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characterization of third-generation cephalosporin, carbapenem and colistin-resistant Enterobacterales isolated from clinical samples in Cambodia","authors":"Gauthier Delvallez ,&nbsp;Sokleaph Cheng ,&nbsp;Florian Girond ,&nbsp;Sidonn Krang ,&nbsp;Soda Meng ,&nbsp;Puthea Nop ,&nbsp;Seiha Heng ,&nbsp;Samrach Han ,&nbsp;Sokunthy Keo ,&nbsp;Kunthea Kong ,&nbsp;Anne-Laure Bañuls ,&nbsp;Mallorie Hide","doi":"10.1016/j.nmni.2025.101649","DOIUrl":"10.1016/j.nmni.2025.101649","url":null,"abstract":"<div><h3>Objectives</h3><div>Despite the threat of antimicrobial resistance (AMR) worldwide, limited studies describe the situation in human infections in Cambodia. Our study aims to evaluate the current state of AMR and describe the resistance mechanisms of the main Enterobacterales responsible for various infections in Cambodia.</div></div><div><h3>Methods</h3><div>Between January and April 2020, 222 clinical Enterobacterales isolates were collected from routine diagnostics at the Medical Biology Laboratory of the Institut Pasteur du Cambodge, Phnom Penh. Antimicrobial susceptibility testing and resistance phenotype analysis were performed. Beta-lactamase genes <em>bla</em>_CTX-M<em>, bla</em>_SHV<em>, bla</em>_TEM and <em>bla</em>_OXA-1 were screened in isolates resistant to third generation cephalosporin (3 GC). Carbapenem-resistant isolates were tested for carbapenemase production using a rapid immunochromatographic assay and confirmed by gene detection. Isolates harboring <em>bla</em>_CTX-M and carbapenemase genes were further characterized by sequencing.</div></div><div><h3>Results</h3><div>Overall, 39.2 % of isolates were resistant to at least one 3 GC, with 30.2 % confirmed as extended-spectrum beta-lactamase (ESBL) producers. The corresponding ESBL genes pertain to the KLUB/CTX-M-1 and KLUY/CTX-M-9 classes. Carbapenemase genes <em>bla</em>_NDM and <em>bla</em>_OXA–48 were detected in 4.1 % of isolates. Notably, 6.5 % of ESBL-producing <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> also exhibited colistin resistance.</div></div><div><h3>Conclusion</h3><div>The prevalence and molecular characterization of 3 GC-resistant and ESBL-producing Enterobacterales in our study is consistent with recent reports. Our findings further confirm the high rate of carbapenemase producing Enterobacterales (NDM and OXA-48), including in community-acquired infections. Additionally, we report notable colistin resistance among ESBL producing <em>E. coli</em> and <em>K. pneumoniae</em> isolates. These results highlight the urgent need for AMR strengthened surveillance and antimicrobial stewardship programs in Cambodia.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101649"},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between positive preadmission screening and COVID-19 community transmission: A retrospective observational study during an emergent novel infectious disease pandemic","authors":"Shingo Mitsushima ,&nbsp;Yasushi Ohkusa ,&nbsp;Kiyosu Taniguchi ,&nbsp;Yasuharu Tokuda ,&nbsp;Kenji Shibuya","doi":"10.1016/j.nmni.2025.101647","DOIUrl":"10.1016/j.nmni.2025.101647","url":null,"abstract":"<div><h3>Background</h3><div>After COVID-19 emerged, hospitals adopted preadmission screening to detect asymptomatic cases and avert nosocomial outbreaks; whether such clinical screening should be routine policy remains debated and has not been quantified in Japan.</div></div><div><h3>Objective</h3><div>To evaluate preadmission clinical screening as a component of pandemic preparedness.</div></div><div><h3>Methods</h3><div>The primary outcome was positivity on preadmission screening. We modeled COVID-19 positivity among asymptomatic preadmission patients using regression and a Tobit specification to accommodate excess zeros, then developed a predictive model. Analyses used hospital data linked to prefecture-level indicators of community transmission, including newly confirmed cases and influenza-like-illness (ILI) sentinel activity.</div></div><div><h3>Results</h3><div>In this single-center retrospective study, 5897 newly confirmed COVID-19 cases were analyzed at the hospital. During the same period, Mie Prefecture reported 355,879 cases overall, including 45,551 visits to ILI sentinel sites. In 2022, screening positivity among asymptomatic preadmission patients correlated strongly with the number of newly confirmed cases in the prefecture. The model predicted non-zero screening positivity when newly confirmed prefectural cases exceeded ∼10,000, regardless of assumed ILI positivity. When prefectural cases were &lt;2,000, predicted screening positivity was ∼0 even if assumed ILI positivity was ∼40 %.</div></div><div><h3>Discussion and conclusions</h3><div>Findings suggest conditions for conducting preadmission clinical screening during the COVID-19 pandemic, which can support healthcare infrastructure preparedness against pandemics of novel infectious diseases.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101647"},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and relationship between antibiotic consumption and carbapenem-resistant Gram-negative bacteria at a tertiary hospital in shaanxi, China from 2011 to 2023","authors":"Hai yue Bai ,&nbsp;Jing Wang ,&nbsp;Chen Ma ,&nbsp;An ni Yu ,&nbsp;Yin Wu ,&nbsp;Di Zhang","doi":"10.1016/j.nmni.2025.101648","DOIUrl":"10.1016/j.nmni.2025.101648","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenem-resistant infections are increasing, posing a serious public health threat. This study investigates the relationship between carbapenem-resistant Gram-negative (CRGN) organisms and antimicrobial consumption in a tertiary hospital from 2011 to 2023, particularly focusing on carbapenem consumption.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on quarterly data from 2011 to 2023 at the First Affiliated Hospital of Xi'an Jiaotong University (FAHXJU), covering antibiotic consumption and the incidence rates of carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP), carbapenem-resistant <em>Enterobacter coli</em> (CREC), carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB), and carbapenem-resistant <em>Pseudomonas aeruginosa</em> (CRPA). Antibiotics consumption was expressed as the number of defined daily doses/1000 patient-days (DDDs/1000 PDs). Trends and correlations assessed by regression and Spearman tests.</div></div><div><h3>Results</h3><div>First, the total antibiotics consumption remained stable (β = 0.039, <em>P</em> ≥ 0.05). However, the consumption of carbapenems significantly increased (<em>P</em> &lt; 0.05), from the lowest 7.91 to the highest 57.96 DDDs/1000 PDs. Second, the resistance rates of CRKP (β = 0.364) and CREC (β = 0.035) showed an upward trend (<em>P</em> &lt; 0.05). While the resistance rates of CRAB (β = −0.096, <em>P</em> ≥ 0.05) and CRPA (β = −0.078, <em>P</em> ≥ 0.05) remained stable, a positive correlation was found between carbapenem use and resistance rates of CRKP and CREC (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Despite stable overall antibiotic use, carbapenem consumption has increased substantially and is significantly correlated with the rising resistance of CRKP and CREC. Targeted antimicrobial stewardship and empirical therapy optimization are urgently needed, with future multicenter studies are required to validate these findings.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101648"},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langya henipavirus (LayV) as an emerging zoonotic disease: a mini-review","authors":"Maryam Shafaati ,&nbsp;Milad Zandi","doi":"10.1016/j.nmni.2025.101643","DOIUrl":"10.1016/j.nmni.2025.101643","url":null,"abstract":"<div><div>Henipavirus is one of the genera in the <em>Orthoparamyxovirinae</em> subfamily, which includes several emerging viruses that pose a major public health threat. The predominant members of the virus genus, Hendra and Nipah viruses, are extremely virulent zoonotic viruses that cause neurological and respiratory infections and outbreaks in humans. The recently discovered Langya henipavirus, a new henipavirus phylogenetically related to Mojiang henipavirus (MojV), has been associated with febrile illness in patients from China who are mainly agricultural workers. Active surveillance must be conducted worldwide in an open and collaborative manner to reduce the likelihood of this new virus causing a health crisis. More research is needed to address the remaining difficulties.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101643"},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria vaccines: Current developments and immunological insights","authors":"Akanksha Verma ,&nbsp;Ritesh Ranjha ,&nbsp;Kuldeep Singh ,&nbsp;Vinod Yadav ,&nbsp;Ashima Bhaskar ,&nbsp;Ved Prakash Dwivedi ,&nbsp;Mradul Mohan","doi":"10.1016/j.nmni.2025.101646","DOIUrl":"10.1016/j.nmni.2025.101646","url":null,"abstract":"<div><div>Malaria is a parasitic disease of public health concern affecting nearly 263 million people globally. Majorly, poor and developing countries are prone to malaria. Children under 5 years are most susceptible to malaria morbidity and mortality. The emergence of drug-resistant parasites is posing a threat to the malaria control and elimination goals. There is a need of the hour to develop new <em>anti</em>-malarials along with novel malaria vaccines. The genetic complexity of the parasite and multiple life stages make it challenging to develop malaria vaccines. So far, the WHO has approved only two malaria vaccines. This review discusses the prospects of these two malaria vaccines and the future vaccine candidates targeting different life stages of <em>Plasmodium</em>. It also highlights the recent development in identifying the host's immune responses against malaria, novel vaccine candidates, and the ideal vaccine requirement.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101646"},"PeriodicalIF":5.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological profile of sterile site organisms and culture positivity rates from a decade of paediatric admissions at a tertiary hospital in South Africa: A lower and middle-income country perspective","authors":"Prenika Jaglal ,&nbsp;Khine Swe-Swe Han ,&nbsp;Colin Menezes ,&nbsp;Sithembiso Velaphi","doi":"10.1016/j.nmni.2025.101644","DOIUrl":"10.1016/j.nmni.2025.101644","url":null,"abstract":"<div><h3>Background</h3><div>Sterile site (SS (blood and cerebrospinal fluid)) infections are formidable causes of childhood morbidity and fatality. This study aimed to determine aetiological organisms, antimicrobial resistance patterns and sepsis trend rates in paediatric inpatients from a low-and middle-income country.</div></div><div><h3>Methods</h3><div>A retrospective review of SS culture results of inpatients from the neonatal unit (NNU), general paediatric (GPW) and paediatric haematology-oncology wards (PHOW) at Chris Hani Baragwanath Academic Hospital, South Africa, from January 2013 to December 2022.</div></div><div><h3>Results</h3><div>A total of 58 053 SS specimens were submitted for analysis. Culture-positivity rate was 36.0 %, comprising 22.8 % and 13.2 % for pathogens and contaminants. Pathogen culture-positivity rate was higher in the NNU when compared to GPW (35.5 % vs 17.6 %; OR–5.38; 95 % CI 4.99–5.81) but lower than PHOW (35.5 % vs 46.6 %; OR-0.47; 95 % CI 0.39–0.52). Infection rates per 1000 patient-days increased from 1.74 in 2013 to 3.11 in 2022. Gram-negative bacteria (GNB) (66.0 % vs 18.7 %, OR-5.70; 95 % CI 5.23–6.19) and yeast (12.4 % vs 8.4 %, OR-7.66; 95 % CI 6.13–9.57) were more common in NNU than GPW. Multidrug-resistant (MDR) pathogen prevalence was 35.1 % with extended-spectrum beta-lactamase Enterobacterales contributing 40–50 %. Carbapenem-resistant <em>Acinetobacter</em> species increased from 40 % to 60 % from 2013 to 2022 (p = 0.004). MRSA prevalence decreased from 30 % to 10 % from 2013 to 2022 (p = 0.004).</div></div><div><h3>Conclusion</h3><div>The burden of paediatric MDR gram-negative SS infection was relatively high requiring ongoing surveillance, judicious antimicrobial use, while reinforcing infection control contact-based transmission precautions. Further studies on drivers of antimicrobial resistance such as unit specific antimicrobial consumption rates and prescriber practices, should be explored.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101644"},"PeriodicalIF":5.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual transmission of terbinafine-resistant Trichophyton indotineae among men who have sex with men","authors":"Liza Benzoni ,&nbsp;Matthieu Godinot ,&nbsp;Jean Berset de Vaufleury ,&nbsp;Victoire Reynaud ,&nbsp;Damien Dupont ,&nbsp;Pauline Tirard-Collet ,&nbsp;Jean Menotti ,&nbsp;François Durupt","doi":"10.1016/j.nmni.2025.101645","DOIUrl":"10.1016/j.nmni.2025.101645","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101645"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}