New Microbes and New Infections最新文献

{"title":"The impact of the COVID-19 pandemic on nosocomial infections and antimicrobial resistance (AMR) in intensive care units","authors":"Lamiae Bennis,&nbsp;Youssef Elouardi,&nbsp;Hamza El Aarabi,&nbsp;Imane Oussayeh,&nbsp;Mohammed Khallouki","doi":"10.1016/j.nmni.2025.101662","DOIUrl":"10.1016/j.nmni.2025.101662","url":null,"abstract":"<div><div>The COVID-19 pandemic may have influenced healthcare-associated infections (HAIs) and antimicrobial resistance (AMR), particularly in intensive care units (ICUs).</div><div>We performed a retrospective study in the ICU of Ibn Tofail Hospital, Marrakech, Morocco from March to September 2022. Patients hospitalized for more than 48 h were included. HAIs were defined according to CDC criteria, and antimicrobial susceptibility testing followed EUCAST guidelines. Results were compared with pre-pandemic data from 2019. Of 187 admitted patients, 145 were eligible, and 38 developed an HAI (26.3 %). The most frequent infections were pneumonia (37 %), catheter-related infections (27.5 %), and urinary tract infections (16.1 %). Among 112 isolates, Gram-negative bacteria predominated (82.7 %), mainly <em>Klebsiella pneumoniae</em> (26.8 %), <em>Acinetobacter baumannii</em> (17.9 %), and <em>Pseudomonas aeruginosa</em> (14.3 %). Compared with 2019 (98 isolates), <em>K. pneumoniae</em> increased significantly (17.3 % vs. 26.8 %, p = 0.048). Resistance to ceftazidime rose in <em>P. aeruginosa</em> (22.2 % vs. 56.3 %, p = 0.042), while methicillin resistance in <em>Staphylococcus aureus</em> declined (75.0 % vs. 25.0 %, p = 0.044). No significant changes were observed in carbapenem resistance. Multidrug resistance remained widespread (45.9 % vs. 50.9 %, p = 0.458).</div><div>HAIs in this ICU were mainly due to Gram-negative bacteria, with notable shifts in <em>K. pneumoniae</em> prevalence and specific resistance patterns after the pandemic. While multidrug resistance remains a pressing concern, most changes were limited in scope. These findings provide locally relevant data that can inform infection control and AMR surveillance strategies in North African ICUs.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101662"},"PeriodicalIF":5.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic characterization of cefotaxime-resistant Proteobacteria isolated from a bat-harboring cave in Zambia","authors":"Misheck Shawa ,&nbsp;Harvey Kakoma Kamboyi ,&nbsp;Herman Chambaro ,&nbsp;Kyoko Hayashida ,&nbsp;Naganori Nao ,&nbsp;Joseph Chizimu ,&nbsp;Mike Nundwe ,&nbsp;Tuvshinzaya Zorigt ,&nbsp;Naoko Kawai ,&nbsp;Shohei Ogata ,&nbsp;Joseph Ndebe ,&nbsp;Mwamba Nsofwa ,&nbsp;Msangwa Sinjani ,&nbsp;Situmbeko J. Nasilele ,&nbsp;Mulemba Samutela ,&nbsp;Manyando Simbotwe ,&nbsp;Katendi Changula ,&nbsp;Hirofumi Sawa ,&nbsp;Bernard M. Hang'ombe ,&nbsp;Yasuhiko Suzuki ,&nbsp;Hideaki Higashi","doi":"10.1016/j.nmni.2025.101661","DOIUrl":"10.1016/j.nmni.2025.101661","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Bats are widely recognized as reservoirs of emerging and re-emerging pathogens, and their ecological interactions with humans and livestock present important opportunities for the transmission of infectious agents and antimicrobial resistance (AMR). However, little is known about the occurrence of resistant bacteria in bat-associated environments in Zambia or their potential role in the maintenance of AMR outside clinical and agricultural settings. This study investigated the genomic characteristics of cefotaxime-resistant Proteobacteria isolated from bat fecal droppings collected at Leopards Hill Cave, an established hotspot for zoonotic pathogens. Four hundred bat fecal samples were cultured on cefotaxime-supplemented MacConkey agar, and those exhibiting bacterial growth were subjected to antimicrobial susceptibility testing and whole-genome analysis. Of the 400 samples processed, four (1 %) yielded growth, resulting in three bacterial species: &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; (n = 1), &lt;em&gt;Enterobacter mori&lt;/em&gt; (n = 1), and &lt;em&gt;Brucella intermedia&lt;/em&gt; (formerly &lt;em&gt;Ochrobactrum intermedium&lt;/em&gt;) (n = 2). Genomic screening revealed that &lt;em&gt;P. aeruginosa&lt;/em&gt; strain CB_234 harbored &lt;em&gt;bla&lt;/em&gt;&lt;sub&gt;OXA-50&lt;/sub&gt;, &lt;em&gt;aph(3′)-IIb&lt;/em&gt;, and &lt;em&gt;catB7&lt;/em&gt;, which confer resistance to β-lactams, aminoglycosides, and chloramphenicol, respectively. It also possessed multiple virulence determinants involved in adherence, motility, and secretion systems that enhance host colonization and environmental persistence. Core genome phylogenetic analysis placed CB_234 within a clade exclusively composed of clinical isolates from Nigeria, Thailand, Russia, Kenya, and Ghana, indicating a shared evolutionary lineage among globally dispersed hospital-associated strains. Conversely, environmental isolates from plant and aquatic sources, along with a dog-associated isolate, were phylogenetically distant, highlighting the distinct evolutionary origins. The &lt;em&gt;E. mori&lt;/em&gt; isolate carried &lt;em&gt;bla&lt;/em&gt;&lt;sub&gt;ACT&lt;/sub&gt; and &lt;em&gt;qnrE&lt;/em&gt; resistance genes and plasmid replicons, suggesting potential mobility of resistance traits through horizontal gene transfer. In contrast, the two &lt;em&gt;B. intermedia&lt;/em&gt; isolates did not harbor any known AMR genes or plasmid replicons. However, this species is increasingly recognized as an opportunistic pathogen. The detection of AMR-associated bacterial species in a natural bat habitat supports the evidence of resistance determinants circulating in wildlife environments in Zambia. Given that bats are unlikely to encounter clinical antibiotics directly, the persistence of such genes in their environment suggests that natural ecosystems may play an underappreciated role in maintaining AMR reservoirs independent of direct antimicrobial pressure. These findings underscore the importance of incorporating wildlife and environmental niches into national and global AMR surveillance frameworks under a One Health approach to better unders","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101661"},"PeriodicalIF":5.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strongyloides stercoralis hyperinfection with thrombosis: A systematic review of case reports","authors":"Darío S. López-Delgado ,&nbsp;Carlos A. Narváez ,&nbsp;Roberto Bonfante-Villalobos ,&nbsp;Joshua Emmanuel Arteaga ,&nbsp;Hector Fabio Sanchez-Galvez ,&nbsp;Andres Ricaurte-Fajardo ,&nbsp;Lysien Zambrano ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2025.101659","DOIUrl":"10.1016/j.nmni.2025.101659","url":null,"abstract":"<div><h3>Background</h3><div><em>Strongyloides stercoralis</em> hyperinfection syndrome (SHS) is a severe complication of strongyloidiasis, typically in immunosuppressed patients. While sepsis and multiorgan dysfunction are well recognized, the association with thrombotic complications remains underexplored.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of case reports and case series following PRISMA 2020 guidelines. PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched through December 2024. Eligible studies included patients with SHS or disseminated strongyloidiasis and confirmed thrombotic events. Data on demographics, risk factors, infection characteristics, thrombosis, treatment, and outcomes were extracted and narratively synthesized.</div></div><div><h3>Results</h3><div>Fourteen studies describing 16 cases of SHS with thrombosis published between 2013 and 2024 were included. Median age was 66 years (range 40–87), with a slight male predominance. Most patients (68.8%) were immunosuppressed, primarily due to corticosteroid therapy. Thrombotic events were heterogeneous, including deep vein thrombosis, pulmonary embolism, portal and renal vein thrombosis, intracardiac thrombi, and disseminated intravascular coagulation. Multifocal thrombosis (arterial + venous) occurred in 3/16 (18.8%) cases; shock was present in 5/16 (31.3%). Ivermectin was the mainstay of therapy, alone or with albendazole, although treatment regimens were inconsistently reported. Anticoagulation was frequently initiated, and two cases required thrombectomy. Despite treatment, overall mortality reached 31.3%, particularly among immunosuppressed patients with shock or disseminated thrombosis.</div></div><div><h3>Conclusions</h3><div>SHS can be complicated by diverse and often fatal thrombotic events, especially in immunosuppressed individuals. Clinical suspicion should be heightened in patients from endemic regions or those receiving corticosteroids. Early empiric antiparasitic therapy, timely investigation for thrombotic complications, and individualized anticoagulation strategies are essential to improving outcomes. Given the reliance on case-level evidence, prospective studies and standardized reporting are urgently needed to characterize better risk factors, optimal management, and prognosis of this neglected but critical complication.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101659"},"PeriodicalIF":5.4,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amazon environment sharing featuring humans - dogs - capybaras and more. Adapting a one-health approach to leptospirosis prevention in Indigenous riverine communities in Ecuador and beyond","authors":"Jacob van der Ende ,&nbsp;Jacob M. Bezemer ,&nbsp;Thomas Hanscheid ,&nbsp;Martin P. Grobusch ,&nbsp;Gabriel Trueba","doi":"10.1016/j.nmni.2025.101658","DOIUrl":"10.1016/j.nmni.2025.101658","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101658"},"PeriodicalIF":5.4,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of fungal urinary tract infections: A retrospective case series","authors":"Aiah M. Khateb ,&nbsp;Lina S Alamri ,&nbsp;Ward A Alseyoufi ,&nbsp;Yara H Almusaiferi ,&nbsp;Osama Y. Safdar","doi":"10.1016/j.nmni.2025.101657","DOIUrl":"10.1016/j.nmni.2025.101657","url":null,"abstract":"<div><h3>Background</h3><div>Fungal urinary tract infections (FUTIs) are a growing concern among hospitalized patients, with <em>Candida albicans</em> being the most common causative agent. The aim of this case series was to describe the clinical and microbiological characteristics of FUTIs in patients admitted to a key hospital in the Madinah region.</div></div><div><h3>Materials and methods</h3><div>This retrospective observational study used data from all hospitalized patients with positive urine cultures for fungal infections accompanied by clinical symptoms at King Fahd Hospital between June 2016 and October 2019. Patient demographics, clinical comorbidities, and microbiological data were collected for analysis.</div></div><div><h3>Results</h3><div>During the study period, 46 patients with confirmed FUTIs were identified from 87,447 admissions. There was a dramatic increase in the number of cases every year. <em>C. albicans</em> was the most frequently isolated organism, accounting for 86.9 % cases. Renal disease was the most prevalent comorbidity.</div></div><div><h3>Conclusion</h3><div>This case series highlights the demographic and clinical characteristics of patients with confirmed FUTIs, providing valuable insights into the increasing burden of these infections in hospital settings. The findings underscore the importance of understanding risk factors and the need for continuous surveillance to inform clinical practice and guide prompt and effective intervention.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101657"},"PeriodicalIF":5.4,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular detection of Haemophilus influenzae type b and non-typeable strains by PCR in infants under one year hospitalized with community-acquired pneumonia in Peru, 2010–2012","authors":"Miguel Angel Aguilar-Luis ,&nbsp;Wilmer Silva-Caso ,&nbsp;Angela Cornejo-Tapia ,&nbsp;Erico Cieza-Mora ,&nbsp;Pablo Weilg ,&nbsp;Carlos Bada ,&nbsp;Olguita del Aguila ,&nbsp;Juana del Valle-Mendoza","doi":"10.1016/j.nmni.2025.101655","DOIUrl":"10.1016/j.nmni.2025.101655","url":null,"abstract":"<div><h3>Background</h3><div>Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality among children under five worldwide. <em>Haemophilus influenzae</em>—particularly encapsulated serotype b (Hib) and non-typeable strains (NTHi)—remains an important pathogen. Peru introduced Hib vaccination nationally in 2004, but pediatric molecular data from the early post-introduction period are limited.</div></div><div><h3>Objectives</h3><div>To estimate the molecular prevalence of Hib and NTHi and identify associated clinical/epidemiological factors among infants (&lt;1 year) hospitalized with CAP in Peru during 2010–2012, providing an early post-introduction baseline to inform long-term trends. <em>Method</em>: We conducted a prospective multicenter study in five hospitals. Nasopharyngeal swabs underwent conventional PCR for <em>H. influenzae</em> detection (1000-bp) and serotyping (Hib 310-bp; NTHi 550-bp). Associations were evaluated using χ²/Fisher's tests and multivariable logistic/multinomial regression.</div></div><div><h3>Results</h3><div>Among 339 infants, <em>H. Influenzae</em> was detected in 26.8 % (91/339): Hib 24.2 % (22/91), NTHi 3.3 % (3/91), and other encapsulated serotypes 72.5 % (66/91). In adjusted models, absence of documented Hib vaccination before admission was independently associated with Hib detection (p &lt; 0.001). Atelectasis was associated with non-b encapsulated serotypes (RRR 2.41; 95 % CI 1.02–5.74; p = 0.046). Age and sex showed no independent associations.</div></div><div><h3>Conclusion</h3><div>These findings do not represent the current epidemiology; rather, they delineate an early post-introduction baseline for Hib/NTHi in Peruvian infants with CAP. Our findings contribute to the timeline of <em>H. influenzae</em> epidemiology in Peru, supports evaluations of vaccine impact over time, and underscores the need for sustained molecular surveillance and on-schedule Hib vaccination.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101655"},"PeriodicalIF":5.4,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics of pediatric respiratory pathogens and their association with climate in Wuxi, Chongqing, China","authors":"Caili Luo ,&nbsp;Xingyu Wang ,&nbsp;Na Zhou","doi":"10.1016/j.nmni.2025.101656","DOIUrl":"10.1016/j.nmni.2025.101656","url":null,"abstract":"<div><h3>Background</h3><div>Acute respiratory infections impose a disproportionate burden on pediatric populations, yet climate-pathogen interactions remain poorly characterized in rural China.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 7627 nasopharyngeal samples from children (&lt;18 years) presenting with ARI symptoms at Wuxi People's Hospital (April 2023–March 2025). Six major pathogens--respiratory syncytial virus (RSV), influenza A/B (IAV/IBV), human rhinovirus (HRV), adenovirus (HAdV), and Mycoplasma pneumoniae (MP)--were detected by quantitative PCR. The association between meteorological factors and pathogen prevalence was examined.</div></div><div><h3>Results</h3><div>HRV (22.18 %), IAV (18.54 %), and RSV (16.56 %) were the most prevalent pathogens, with RSV and HAdV showing higher hospitalization rates. Male children were more susceptible to all pathogens, particularly RSV (p = 0.024). Age-specific distributions revealed RSV dominance in infants (28 days-1 year) and toddlers (1–3 years), HRV and HAdV in preschoolers (3–6 years), and IAV and MP in school-aged children (6–18 years). Seasonal trends included year-round HRV and HAdV circulation, winter peaks for IAV and RSV, and an unexpected summer MP surge (26.88 % in June 2024). RSV exhibited an initial epidemic in 2023 (peak positivity: 52.27 % in April) with resurgence in October 2024. Climate analysis revealed temperature-dependent transmission: IAV/IBV correlated with colder temperatures. Notably, MP displayed atypical summer predominance in 2024, peaking at 26.88 % in June (25.2 °C, 77.3 % humidity).</div></div><div><h3>Conclusion</h3><div>This study characterizes the epidemiological and climatic drivers of pediatric ARIs in Wuxi, China, underscoring pathogen-specific age distributions, seasonal anomalies, and climate interactions. The findings emphasize the need for sustained surveillance to monitor emerging respiratory threats and inform targeted interventions.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101656"},"PeriodicalIF":5.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of yellow fever in cases from Bolivia, Ecuador, Colombia, and Peru (2023–2025): A descriptive retrospective study","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Boris Chang-Cheng ,&nbsp;Rosmery Gross ,&nbsp;Oscar Eduardo Llanque-Espinoza ,&nbsp;Jesus Villamil-Macareno ,&nbsp;Cristian Pacheco-Jimenez ,&nbsp;Gabriela Belén Pineda-Bersoza ,&nbsp;Nelson Fernando Delgado-Torres ,&nbsp;Ivan Camilo Sanchez-Rojas ,&nbsp;Catherin Lorena Solarte-Jimenez ,&nbsp;Eibar Camilo Chamorro-Velazco ,&nbsp;Glinys Edith Diaz-Llerena ,&nbsp;Cristian Daniel Arevalo ,&nbsp;Olga Lucia Cuasquer-Posos ,&nbsp;Jorge Luis Bonilla-Aldana ,&nbsp;D. Katterine Bonilla-Aldana ,&nbsp;Franklin Rómulo Aguilar-Gamboa ,&nbsp;Johana E. Aparicio-Sigueñas ,&nbsp;Miguel Villegas-Chiroque ,&nbsp;Sergio Luis Aguilar-Martinez ,&nbsp;Wilmer E. Villamil-Gómez","doi":"10.1016/j.nmni.2025.101651","DOIUrl":"10.1016/j.nmni.2025.101651","url":null,"abstract":"<div><h3>Background</h3><div>Yellow fever (YF) persists as a major arboviral threat in South America, despite the availability of an effective vaccine. While Brazil has produced extensive clinical descriptions, data from Bolivia, Ecuador, Colombia, and Peru remain limited.</div></div><div><h3>Methods</h3><div>We conducted a descriptive retrospective multicenter analysis of laboratory-confirmed YF cases reported between January 2023 and August 2025 in four Andean countries. Demographic, epidemiological, clinical, and laboratory data were extracted from hospital and surveillance records.</div></div><div><h3>Results</h3><div>Twenty-one confirmed cases were identified: Bolivia (n = 8), Ecuador (n = 5), Colombia (n = 4), and Peru (n = 4). The median age was 25 years (IQR: 16–43), with a predominance of males (81 %). Vaccination history was largely undocumented; 86 % had unknown or absent records. The median delay from symptom onset to hospitalization was 5 days. Outcomes were severe, with a case fatality rate of 57 % (12/21), and the median time from symptom onset to death was 8 days. Early manifestations included fever (71 %), arthralgia (19 %), headache (19 %), and myalgia (19 %). During the toxic phase (severe disease), hemorrhage (86 %), jaundice (62 %), circulatory collapse (57 %), and hepatic dysfunction (52 %) predominated. Complications included intracranial hemorrhage, multiorgan dysfunction, sepsis, and renal failure. Laboratory findings revealed marked hepatic injury (AST median, 3257 U/L; ALT median, 1570 U/L), hyperbilirubinemia, metabolic acidosis, elevated lactate levels, hypoglycemia, and coagulopathy. RT-PCR for YFV was positive in 95 % of tested cases.</div></div><div><h3>Conclusions</h3><div>This study provides one of the first systematic clinical characterizations of YF cases from Bolivia, Ecuador, Colombia, and Peru. The high fatality rate, despite the young age of patients, underscores the vulnerability of populations in resource-limited, peri-Amazonian settings. Severe hepatic dysfunction, hemorrhage, and systemic collapse were consistent hallmarks of the disease. These findings highlight the urgent need to strengthen vaccination coverage, enhance clinical recognition, and expand access to critical care in outbreak-prone areas of South America.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101651"},"PeriodicalIF":5.4,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloodstream infections in Cameroon: a systematic review and meta-analysis","authors":"Moise Matakone ,&nbsp;Sen Claudine Henriette Ngomtcho ,&nbsp;Patrice Landry Koudoum ,&nbsp;Isaac Dah ,&nbsp;Ravalona Jessica Zemtsa ,&nbsp;Michel Noubom","doi":"10.1016/j.nmni.2025.101654","DOIUrl":"10.1016/j.nmni.2025.101654","url":null,"abstract":"<div><h3>Background</h3><div>Bloodstream infections (BSIs) are significantly associated with morbidity and mortality worldwide, and particularly in low-resource settings. We determined the prevalence of BSIs, profile, and antimicrobial resistance of the causing bacteria in Cameroon.</div></div><div><h3>Methods</h3><div>PubMed, Google Scholar and ScienceDirect databases were searched to identify relevant studies. The random or fixed effect model was used depending on the level of heterogeneity among studies for pooling estimates after the variance was stabilised through the Freeman-Tukey double arcsine transformation. Begg's and Egger's tests were used to quantify publication bias. The protocol was registered in PROSPERO (CRD42023482760).</div></div><div><h3>Results</h3><div>The analysis of 5680 blood cultures from ten studies revealed an overall bacterial BSI prevalence of 25.2 % (95 % CI: 18.1–33.2 %) and 17.2 % (11.6–23.7 %) when the potential contaminants were removed. The leading BSI-causing bacteria were <em>Escherichia coli</em>, <em>Klebsiella</em> species, and <em>Staphylococcus aureus</em>. We found significant resistance to clinically relevant antibiotics, particularly to extended-spectrum cephalosporins in <em>E. coli</em>, <em>Klebsiella</em> species and <em>Acinetobacter</em> species, whereas resistance rates were lowest against carbapenems. Staphylococci displayed resistance rates above 30 % to all tested antibiotics. WHO bacterial priority pathogens occupied a greater proportion of the overall BSI-driven bacteria.</div></div><div><h3>Conclusion</h3><div>This study reports a substantial prevalence of BSI and resistance to the commonly used antibiotics. It also points out the lack of compliance with international guidelines in microbiological analysis. This highlights the need to empower laboratories’ capacities and conduct BSI surveillance across the country to develop more targeted strategies for the prevention, management and treatment of BSIs.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101654"},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acinetobacter towneri harbouring blaNDM-1 and blaOXA-58: genomic characterization of the first human isolate from Brazil","authors":"Daiana Cristina Silva Rodrigues ,&nbsp;Bruna Ribeiro Sued-Karam ,&nbsp;Melise Chaves Silveira ,&nbsp;Orlando Carlos da Conceição-Neto ,&nbsp;Bruno Rocha Pribul ,&nbsp;Ana Paula D'Alincourt Carvalho-Assef ,&nbsp;Cláudio Marcos Rocha-de-Souza","doi":"10.1016/j.nmni.2025.101652","DOIUrl":"10.1016/j.nmni.2025.101652","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101652"},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}