Pub Date : 2024-10-10DOI: 10.1016/j.nmni.2024.101506
Qiushi Zheng , Jian Bing , Shiling Han , Shuyun Guan , Tianren Hu , Lei Cai , Haiqing Chu , Guanghua Huang
Several human fungal pathogens, including drug-resistant Candida auris and species of the Candida haemulonii complex, have emerged over the past two decades, posing new threats to human health. In this study, we report the isolation and identification of a novel species belonging to the genus Clavispora, herein named as Clavisporasputum, from a clinical sputum sample of a COVID-19 patient. Cl. sputum is phylogenetically closely related to fungal pathogens Clavispora lusitaniae (syn. Candida lusitaniae) and C. auris. When grown on CHROMagar Candida Plus medium, Cl. sputum exhibited a similar coloration to C. auris strain CBS12372. Cl. sputum was able to develop weak filaments on CM medium. Although Cl. sputum and Cl. lusitaniae are phylogenetically closely related, comparative genomic and synteny analyses indicated significant chromosomal rearrangements between the two species. Although Cl. sputum could not grow at 37 °C under regular culture condition, an increased fungal burden in the lung tissue of a mouse systemic infection model implies that it could be a potential opportunistic pathogenic yeast in humans.
在过去二十年中，出现了多种人类真菌病原体，包括耐药白色念珠菌和haemulonii白色念珠菌复合菌种，对人类健康构成了新的威胁。在这项研究中，我们报告了从一名 COVID-19 患者的临床痰液样本中分离和鉴定出的属于 Clavispora 属的一个新物种，在此命名为 Clavispora sputum。Cl. sputum 在系统发育上与真菌病原体 Clavispora lusitaniae（同属 Candida lusitaniae）和 C. auris 关系密切。当在 CHROMagar Candida Plus 培养基上生长时，Cl.痰表现出与 C. auris 菌株 CBS12372 相似的颜色。痰菌在 CM 培养基上能长出细弱的菌丝。虽然痰菌和卢西塔尼亚痰菌在系统发育上关系密切，但比较基因组和同源染色体分析表明这两个物种之间存在明显的染色体重排。虽然痰酵母菌不能在 37 °C的常规培养条件下生长，但小鼠全身感染模型肺组织中真菌负担的增加意味着痰酵母菌可能是人类的一种潜在机会致病酵母菌。
{"title":"Biological and genomic analyses of Clavispora sputum sp. nov., a novel potential fungal pathogen closely related to Clavispora lusitaniae (syn. Candida lusitaniae) and Candida auris","authors":"Qiushi Zheng , Jian Bing , Shiling Han , Shuyun Guan , Tianren Hu , Lei Cai , Haiqing Chu , Guanghua Huang","doi":"10.1016/j.nmni.2024.101506","DOIUrl":"10.1016/j.nmni.2024.101506","url":null,"abstract":"<div><div>Several human fungal pathogens, including drug-resistant <em>Candida auris</em> and species of the <em>Candida haemulonii</em> complex, have emerged over the past two decades, posing new threats to human health. In this study, we report the isolation and identification of a novel species belonging to the genus <em>Clavispora</em>, herein named as <em>Cl</em><em>avispora</em> <em>sputum</em>, from a clinical sputum sample of a COVID-19 patient. <em>Cl</em><em>. sputum</em> is phylogenetically closely related to fungal pathogens <em>Clavispora lusitaniae</em> (syn. <em>Candida lusitaniae</em>) and <em>C. auris</em>. When grown on CHROMagar <em>Candida</em> Plus medium, <em>Cl. sputum</em> exhibited a similar coloration to <em>C. auris</em> strain CBS12372. <em>Cl. sputum</em> was able to develop weak filaments on CM medium. Although <em>Cl. sputum</em> and <em>Cl. lusitaniae</em> are phylogenetically closely related, comparative genomic and synteny analyses indicated significant chromosomal rearrangements between the two species. Although <em>Cl. sputum</em> could not grow at 37 °C under regular culture condition, an increased fungal burden in the lung tissue of a mouse systemic infection model implies that it could be a potential opportunistic pathogenic yeast in humans.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101506"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Re-emergence of Chandipura virus in India: Urgent need for public health vigilance and proactive management","authors":"Ashutosh Pareek, Runjhun Singhal, Aaushi Pareek, Anil Chuturgoon, Ranjit Sah, Rachana Mehta, Jaffar A. Al-Tawfiq, Vasso Apostolopoulos","doi":"10.1016/j.nmni.2024.101507","DOIUrl":"10.1016/j.nmni.2024.101507","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101507"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.nmni.2024.101504
Riyan Al Islam Reshad, Roni Mia, Yusha Araf, Anandha Mozumder, Sharmin Akter, Sukumar Saha, Muzahed Uddin Ahmed, Chirojit Debnath, Mohammad Kamruzzaman Khan, Chitta Ranjan Debnath, Mamun Al Mahtab, Tofazzal Islam, Md. Golzar Hossain
{"title":"Addressing the challenge of Pandoraea sputorum in cystic fibrosis: A call for novel therapeutic strategies","authors":"Riyan Al Islam Reshad, Roni Mia, Yusha Araf, Anandha Mozumder, Sharmin Akter, Sukumar Saha, Muzahed Uddin Ahmed, Chirojit Debnath, Mohammad Kamruzzaman Khan, Chitta Ranjan Debnath, Mamun Al Mahtab, Tofazzal Islam, Md. Golzar Hossain","doi":"10.1016/j.nmni.2024.101504","DOIUrl":"10.1016/j.nmni.2024.101504","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101504"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.nmni.2024.101502
Matteo Coen , Aurélie Foulex , Ilias Bagetakos , Abdessalam Cherkaoui , Jacques Serratrice , Jacques Schrenzel , Anne Iten
Background
Sphingobacterium multivorum is a gram-negative, non-fermentative, oxidase-positive, catalase-positive bacillus. S multivorum has been identified in urinary tract infections, respiratory tract infections, spontaneous peritonitis, septic arthritis, meningitis, bacteraemia and septic shock. Ours is the second case of skin and soft tissue infection sustained by S. multivorum (a case of necrotizing fasciitis with septic shock has been previously reported). In this paper, we furnish a review of the literature on all the cases of S multivorum described in the medical literature (with the different antimicrobial susceptibility profiles for each case).
Case presentation
We describe the case of a dermo-hypodermitis of the right arm, forearm, and postero-lateral abdominal wall sustained by S multivorum. The infection occurred in an 84-year-old woman with a medical history of type 2 diabetes, chronic kidney disease, and refractory psoriatic arthritis treated with tocilizumab.
Discussion
S multivorum is a ubiquitous gram-negative bacillus, characterized by a variable antibiotic susceptibility profile that is difficult to anticipate.
Conclusion
S multivorum is an opportunistic pathogen capable of causing rare but potentially severe infections in patients of all age groups, with a higher prevalence in immunocompromised individuals, as observed in our case.".
{"title":"Sphingobacterium multivorum cellulitis: case report and mini-review","authors":"Matteo Coen , Aurélie Foulex , Ilias Bagetakos , Abdessalam Cherkaoui , Jacques Serratrice , Jacques Schrenzel , Anne Iten","doi":"10.1016/j.nmni.2024.101502","DOIUrl":"10.1016/j.nmni.2024.101502","url":null,"abstract":"<div><h3>Background</h3><div><em>Sphingobacterium multivorum</em> is a gram-negative, non-fermentative, oxidase-positive, catalase-positive bacillus. <em>S multivorum</em> has been identified in urinary tract infections, respiratory tract infections, spontaneous peritonitis, septic arthritis, meningitis, bacteraemia and septic shock. Ours is the second case of skin and soft tissue infection sustained by <em>S. multivorum</em> (a case of necrotizing fasciitis with septic shock has been previously reported). In this paper, we furnish a review of the literature on all the cases of <em>S multivorum</em> described in the medical literature (with the different antimicrobial susceptibility profiles for each case).</div></div><div><h3>Case presentation</h3><div>We describe the case of a dermo-hypodermitis of the right arm, forearm, and postero-lateral abdominal wall sustained by <em>S multivorum</em>. The infection occurred in an 84-year-old woman with a medical history of type 2 diabetes, chronic kidney disease, and refractory psoriatic arthritis treated with tocilizumab.</div></div><div><h3>Discussion</h3><div><em>S multivorum</em> is a ubiquitous gram-negative bacillus, characterized by a variable antibiotic susceptibility profile that is difficult to anticipate.</div></div><div><h3>Conclusion</h3><div><em>S multivorum</em> is an opportunistic pathogen capable of causing rare but potentially severe infections in patients of all age groups, with a higher prevalence in immunocompromised individuals, as observed in our case.\".</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101502"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparedness is key in the face of avian influenza uncertainty","authors":"Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola, Godfred Yawson Scott, Paulina Morales Ruiz","doi":"10.1016/j.nmni.2024.101505","DOIUrl":"10.1016/j.nmni.2024.101505","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101505"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacillus anthracis is a zoonotic bacterium, majorly responsible for causing human anthrax and the possibility of the outbreak spreading globally. Herbivorous animals serve as the inherent reservoir for the disease, whereas all endothermic species are vulnerable. Humans contract the disease inadvertently by contact with diseased animals or animal products or through the consumption or handling of infected flesh. There is no such reported data indicating the transmission of anthrax from human to human, which further does not guarantee the bacterium's mutations and new transmission route. Nevertheless, it can lead to various infections, including endophthalmitis, bacteremia, cutaneous infection, central nervous system infection, and pneumonia. Therefore, it is crucial to examine the present epidemiological situation of human anthrax in densely populated nations, including the altered symptoms, indications in people, and the method of transmission. This article highlights the current diagnostic methods for human anthrax, further examines the available therapy options and future perspectives in treatment protocol. This narrative review resulted from a simple search strategy on “PubMed”, “ScienceDirect”, “ClinicalTrials.gov” and web reports using “AND” as Boolean operator with search keywords, i.e., “Anthrax” AND “Infection”, “Anthrax” AND “Pandemic”, “Anthrax” AND “Infectious disease”, “Anthrax” AND “Vaccine”, “Anthrax” AND “Diagnosis” shows minimal narrative literature in between 2024 and 2005. Furthermore, this narrative review highlights the potential approaches for detecting anthrax infection, establishing suitable protocols for prevention, and focusing on the current epidemiology and available therapeutics, vaccine and its future developmental strategies for the prevention of infectious disorder.
{"title":"Anthrax: A narrative review","authors":"Sumel Ashique , Aritra Biswas , Sourav Mohanto , Shriyansh Srivastava , Md Sadique Hussain , Mohammed Gulzar Ahmed , Vetriselvan Subramaniyan","doi":"10.1016/j.nmni.2024.101501","DOIUrl":"10.1016/j.nmni.2024.101501","url":null,"abstract":"<div><div><em>Bacillus anthracis</em> is a zoonotic bacterium, majorly responsible for causing human anthrax and the possibility of the outbreak spreading globally. Herbivorous animals serve as the inherent reservoir for the disease, whereas all endothermic species are vulnerable. Humans contract the disease inadvertently by contact with diseased animals or animal products or through the consumption or handling of infected flesh. There is no such reported data indicating the transmission of anthrax from human to human, which further does not guarantee the bacterium's mutations and new transmission route. Nevertheless, it can lead to various infections, including endophthalmitis, bacteremia, cutaneous infection, central nervous system infection, and pneumonia. Therefore, it is crucial to examine the present epidemiological situation of human anthrax in densely populated nations, including the altered symptoms, indications in people, and the method of transmission. This article highlights the current diagnostic methods for human anthrax, further examines the available therapy options and future perspectives in treatment protocol. This narrative review resulted from a simple search strategy on “PubMed”, “ScienceDirect”, “ClinicalTrials.gov” and web reports using “AND” as Boolean operator with search keywords, i.e., “Anthrax” AND “Infection”, “Anthrax” AND “Pandemic”, “Anthrax” AND “Infectious disease”, “Anthrax” AND “Vaccine”, “Anthrax” AND “Diagnosis” shows minimal narrative literature in between 2024 and 2005. Furthermore, this narrative review highlights the potential approaches for detecting anthrax infection, establishing suitable protocols for prevention, and focusing on the current epidemiology and available therapeutics, vaccine and its future developmental strategies for the prevention of infectious disorder.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101501"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First autochthonous dengue in Iran: What's next for regional control?","authors":"Nivedita Singh, Hediye Gholamshahi, Amna Zaheer, Sanjit Sah, Mahendra Pratap Singh, Amogh Verma","doi":"10.1016/j.nmni.2024.101499","DOIUrl":"10.1016/j.nmni.2024.101499","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101499"},"PeriodicalIF":2.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Valley fever on the rise: How climate change is fueling a public health crisis","authors":"Pawan Kumar, Jezina Jayan, Diptismita Jena, Nishant Rai, Sanjit Sah, Edward Mawejje","doi":"10.1016/j.nmni.2024.101500","DOIUrl":"10.1016/j.nmni.2024.101500","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101500"},"PeriodicalIF":2.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-04DOI: 10.1016/j.nmni.2024.101498
Ala'a B. Al-Tammemi, Mus'ab Banat
{"title":"Newcastle disease outbreak in the state of Rio Grande do Sul, Brazil 2024: Is there any impact on Jordan as one of the major importers of Brazilian poultry?","authors":"Ala'a B. Al-Tammemi, Mus'ab Banat","doi":"10.1016/j.nmni.2024.101498","DOIUrl":"10.1016/j.nmni.2024.101498","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101498"},"PeriodicalIF":2.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malaria vaccine - A solution to the endemic burden of malaria in the Democratic Republic of the Congo; a call for action","authors":"Chrispin Biamba, Mayar Moustafa Budair, Hazem Mohamed Mousa, Excellent Rugendabanga, Faizullah Jafar, Elie Kihanduka, Samson Hangi, Jones Onesime, Aymar Akilimali","doi":"10.1016/j.nmni.2024.101497","DOIUrl":"10.1016/j.nmni.2024.101497","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101497"},"PeriodicalIF":2.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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