New Microbes and New Infections最新文献

英文中文

Integrating multidisciplinary expertise and technological innovations in tracking infectious diseases 整合多学科专业知识和技术创新，追踪传染病

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-18 DOI: 10.1016/j.nmni.2024.101485

Alberto Rizzo

引用次数: 0

Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases 耐大肠菌素的大肠埃希菌共产 IMP-1 和 OXA-58 碳青霉烯酶的鉴定和特征描述

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-12 DOI: 10.1016/j.nmni.2024.101484

Satoshi Nishida , Yasuo Ono

Background

Carbapenem-resistant Acinetobacter is of increasing global concern because infections are challenging to treat with standard antibiotics. Here, we identified a previously uncharacterised Acinetobacter sp. clinical isolate as Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58. We also examined expression of genes related to antibiotic susceptibility and drug resistance, including bla_IMP.

Methods

The isolate was deposited at the National Institute of Technology and Evaluation (NITE) as Acinetobacter sp. NBRC 110496. Susceptibility was defined according to the Clinical and Laboratory Standards Institute (CLSI) breakpoints. Genomic and clonal analyses were performed to identify species and resistance genes.

Results

The isolate was resistant to β-lactams, including broad-spectrum cephalosporins and carbapenems, polymyxins, and trimethoprim/sulfamethoxazole. Genomic analysis identified the isolate as A. colistiniresistens harbouring bla_IMP-1, bla_OXA-58, bla_OXA-670, aac(6′)-Ib, aac(6′)-Ij, ant(3”)-II, aph(3’)-VI, msrE, mphE, and sul1. Colistin resistance was associated with the eptA-like gene, which encodes a lipid A-modifying enzyme. SNP-based phylogenetic analysis revealed that the strain clustered with other strains isolated in Japan. The IMP-1/OXA-58-producing strain described in this study has a novel integron structure surrounding bla_IMP-1, aacA and sul1.

Conclusions

Colistin-resistant IMP-1/OXA-58-co-producing A. colistiniresistens was identified in a patient. This isolate could serve as a reservoir for carbapenemase-producing organisms. This study suggests that screening for colistin-resistant isolates is crucial to preserve colistin as a therapeutic agent for multidrug-resistant bacteria. Identification of this MDR isolate in Asia, and the danger of it spreading worldwide, should raise serious concerns.

背景由于标准抗生素难以治疗的感染，耐碳酸培南的不动杆菌越来越受到全球关注。在此，我们发现了一种以前未定性的临床分离株醋肽杆菌，它能同时产生 IMP-1 和 OXA-58。我们还检测了与抗生素敏感性和耐药性相关的基因（包括 blaIMP）的表达情况。方法该分离株作为 Acinetobacter sp. NBRC 110496 存于国家技术与评估研究所（NITE）。根据临床和实验室标准研究所（CLSI）的断点来确定敏感性。结果该分离菌对β-内酰胺类耐药，包括广谱头孢菌素和碳青霉烯类、多粘菌素和三甲双胍/磺胺甲噁唑。基因组分析确定该分离株为大肠杆菌，含有 blaIMP-1、blaOXA-58、blaOXA-670、aac(6′)-Ib、aac(6′)-Ij、ant(3")-II、aph(3')-VI、msrE、mphE 和 sul1。秋水仙素抗性与 eptA-like 基因有关，该基因编码一种脂质 A-修饰酶。基于 SNP 的系统发育分析表明，该菌株与日本分离的其他菌株存在聚类。本研究中描述的产 IMP-1/OXA-58 菌株具有围绕 blaIMP-1、aacA 和 sul1 的新型整合子结构。该分离株可能是产碳青霉烯酶菌的储库。这项研究表明，筛查耐大肠菌素的分离株对于保留大肠菌素作为耐多药细菌的治疗药物至关重要。在亚洲发现这种耐多药分离株以及它在全球传播的危险应引起人们的严重关注。

{"title":"Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases","authors":"Satoshi Nishida , Yasuo Ono","doi":"10.1016/j.nmni.2024.101484","DOIUrl":"10.1016/j.nmni.2024.101484","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenem-resistant <em>Acinetobacter</em> is of increasing global concern because infections are challenging to treat with standard antibiotics. Here, we identified a previously uncharacterised <em>Acinetobacter</em> sp. clinical isolate as <em>Acinetobacter colistiniresistens</em> co-producing IMP-1 and OXA-58. We also examined expression of genes related to antibiotic susceptibility and drug resistance, including <em>bla</em><sub>IMP</sub>.</div></div><div><h3>Methods</h3><div>The isolate was deposited at the National Institute of Technology and Evaluation (NITE) as <em>Acinetobacter</em> sp. NBRC 110496. Susceptibility was defined according to the Clinical and Laboratory Standards Institute (CLSI) breakpoints. Genomic and clonal analyses were performed to identify species and resistance genes.</div></div><div><h3>Results</h3><div>The isolate was resistant to β-lactams, including broad-spectrum cephalosporins and carbapenems, polymyxins, and trimethoprim/sulfamethoxazole. Genomic analysis identified the isolate as <em>A. colistiniresistens</em> harbouring <em>bla</em><sub>IMP-1</sub>, <em>bla</em><sub>OXA-58</sub>, <em>bla</em><sub>OXA-670</sub>, <em>aac(6′)-Ib</em>, <em>aac(6′)-Ij</em>, <em>ant(3”)-I</em><em>I</em>, <em>aph(3’)-VI</em>, <em>msrE</em>, <em>mphE</em>, and <em>sul1</em>. Colistin resistance was associated with the <em>eptA</em>-like gene, which encodes a lipid A-modifying enzyme. SNP-based phylogenetic analysis revealed that the strain clustered with other strains isolated in Japan. The IMP-1/OXA-58-producing strain described in this study has a novel integron structure surrounding <em>bla</em><sub>IMP-1</sub>, <em>aacA</em> and <em>sul1</em>.</div></div><div><h3>Conclusions</h3><div>Colistin-resistant IMP-1/OXA-58-co-producing <em>A. colistiniresistens</em> was identified in a patient. This isolate could serve as a reservoir for carbapenemase-producing organisms. This study suggests that screening for colistin-resistant isolates is crucial to preserve colistin as a therapeutic agent for multidrug-resistant bacteria. Identification of this MDR isolate in Asia, and the danger of it spreading worldwide, should raise serious concerns.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101484"},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious diseases within a war-torn health system: The re-emergence of polio in Gaza 饱受战争蹂躏的卫生系统中的传染病：小儿麻痹症在加沙再次出现

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-05 DOI: 10.1016/j.nmni.2024.101483

Dalia Zayed, Mus'ab Banat, Ala'a B. Al-Tammemi

引用次数: 0

Naegleria Fowleri: The prevalence of a brain-eating amoeba in freshwater bodies in India Naegleria Fowleri：食脑阿米巴在印度淡水水体中的流行情况

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-04 DOI: 10.1016/j.nmni.2024.101482

Vardhini Ganesh Iyer, Novonil Deb, Dattatreya Mukherjee, Sanjit Sah, Aroop Mohanty, Vikash Jaiswal , Ranjit Sah

引用次数: 0

Household animals and the risk of hepatitis E for pregnant women 家养动物与孕妇罹患戊型肝炎的风险

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-04 DOI: 10.1016/j.nmni.2024.101481

Milad Zandi, Fatemeh Sadat Mousavi, Hashem Khanbabaei

引用次数: 0

Understanding the surge in Crimean-Congo hemorrhagic fever incidence in Iraq: A call for action 了解伊拉克克里米亚-刚果出血热发病率激增的原因：呼吁采取行动

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-03 DOI: 10.1016/j.nmni.2024.101479

Dana Khdr Sabir, Paywast Jamal Jalal, Fro Rzgar Khdir

引用次数: 0

A Rare Encounter: The first documented human infection of avian influenza A(H5N2) 罕见的遭遇：首次有记录的人类感染甲型 H5N2 禽流感

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-03 DOI: 10.1016/j.nmni.2024.101478

Prakriti Pokhrel, Amogh Verma, Kumud Pant, Mahalaqua Nazli Khatib, Mahendra Pratap Singh, Quazi Syed Zahiruddin, Sarvesh Rustagi, Sanjit Sah

引用次数: 0

Monkeypox crisis: A national public health concern in Democratic Republic of the Congo 猴痘危机：刚果民主共和国的国家公共卫生问题

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-03 DOI: 10.1016/j.nmni.2024.101480

Lucien Baraka, Elie Kihanduka, Mayar Moustafa Budair, Francois Rhugendabanga, Styves Banga, Jones Onesime, Hardy Elembwe, Samson Hangi, Excellent Rugendabanga, Aymar Akilimali

引用次数: 0

Prevalence of and risk factors for infectious disease syndromic symptoms among pilgrimage to Arba'een mass gathering religious in 2023 2023 年前往阿尔巴恩朝圣的群众集会宗教人士中传染病综合症状的流行率和风险因素

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-09-03 DOI: 10.1016/j.nmni.2024.101477

Hosein Azizi , Behrouz Naghili , Fariba Abbasi , Lotfali Haghiri , Elham Davtalab Esmaeili

Background

There is a growing participation of Shia Muslims, in the Arba'een pilgrimage every year. It is imperative to conduct a comprehensive study on the transmission of diseases among Arba'een pilgrims in order to identify and promptly respond to potential epidemics effectively. We aimed to assess the syndromic symptoms associated with infectious diseases and the prevalence of mask usage among patients visiting outpatient clinics during the Arba'een pilgrimage in Ira, in 2023.

Methods

In this descriptive-analytical study, 300 outpatients who sought medical care at outpatient clinics during the Arba'een pilgrimage were randomly selected. The study data and infectious disease syndromic symptoms were assessed using trained healthcare professionals. A multiple logistic regression analysis was carried out to estimate the crude and Adjusted odds ratios (AORs) of symptoms and risk factors associated with respiratory syndrome and flu-like symptoms with 95 % confidence intervals.

Results

The mean age of the participants was 39 years and 61 % of those were male. Out of 72 (24 %) of mask users, 41.6 % had changed masks in less than 8 h. The most common syndromic symptoms was Flu-like illness (53 %). In the final analysis, not wearing a mask AOR = 1.40 (1.1–9.8) and smoking AOR = 3.25 (1.1–9.5) both elevated the risk of the flu-like syndrome and severe respiratory disease symptoms.

Conclusions

Pilgrims are especially vulnerable to the flu and other respiratory illnesses. Therefore, performing a differential diagnosis in these people, including flu and COVID-19, is essential to prevent an outbreak during the Arba'een pilgrimage.

背景什叶派穆斯林每年参加阿尔巴恩朝圣的人数越来越多。当务之急是对阿尔巴恩朝圣者的疾病传播情况进行全面研究，以便及时发现和有效应对潜在的流行病。我们的目的是评估 2023 年阿尔巴恩朝圣期间在伊拉门诊就医的患者中与传染病相关的综合症状和口罩使用率。方法在这项描述性分析研究中，我们随机抽取了 300 名在阿尔巴恩朝圣期间在门诊就医的患者。由经过培训的医护人员对研究数据和传染病综合症状进行评估。结果参与者的平均年龄为 39 岁，其中 61% 为男性。在 72 名口罩使用者（24%）中，41.6% 的人更换口罩的时间少于 8 小时。在最终分析中，不戴口罩 AOR = 1.40 (1.1-9.8) 和吸烟 AOR = 3.25 (1.1-9.5) 都会增加流感样综合征和严重呼吸道疾病症状的风险。因此，对这些人进行鉴别诊断（包括流感和 COVID-19）对于防止在阿尔巴恩朝圣期间爆发疫情至关重要。

{"title":"Prevalence of and risk factors for infectious disease syndromic symptoms among pilgrimage to Arba'een mass gathering religious in 2023","authors":"Hosein Azizi , Behrouz Naghili , Fariba Abbasi , Lotfali Haghiri , Elham Davtalab Esmaeili","doi":"10.1016/j.nmni.2024.101477","DOIUrl":"10.1016/j.nmni.2024.101477","url":null,"abstract":"<div><h3>Background</h3><p>There is a growing participation of Shia Muslims, in the Arba'een pilgrimage every year. It is imperative to conduct a comprehensive study on the transmission of diseases among Arba'een pilgrims in order to identify and promptly respond to potential epidemics effectively. We aimed to assess the syndromic symptoms associated with infectious diseases and the prevalence of mask usage among patients visiting outpatient clinics during the Arba'een pilgrimage in Ira, in 2023.</p></div><div><h3>Methods</h3><p>In this descriptive-analytical study, 300 outpatients who sought medical care at outpatient clinics during the Arba'een pilgrimage were randomly selected. The study data and infectious disease syndromic symptoms were assessed using trained healthcare professionals. A multiple logistic regression analysis was carried out to estimate the crude and Adjusted odds ratios (AORs) of symptoms and risk factors associated with respiratory syndrome and flu-like symptoms with 95 % confidence intervals.</p></div><div><h3>Results</h3><p>The mean age of the participants was 39 years and 61 % of those were male. Out of 72 (24 %) of mask users, 41.6 % had changed masks in less than 8 h. The most common syndromic symptoms was Flu-like illness (53 %). In the final analysis, not wearing a mask AOR = 1.40 (1.1–9.8) and smoking AOR = 3.25 (1.1–9.5) both elevated the risk of the flu-like syndrome and severe respiratory disease symptoms.</p></div><div><h3>Conclusions</h3><p>Pilgrims are especially vulnerable to the flu and other respiratory illnesses. Therefore, performing a differential diagnosis in these people, including flu and COVID-19, is essential to prevent an outbreak during the Arba'een pilgrimage.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101477"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002610/pdfft?md5=94a0242ec2c93b6d066293f982981259&pid=1-s2.0-S2052297524002610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First human fatality from H5N2 virus: Have we learnt lessons in pandemic preparedness? H5N2 病毒造成首例人类死亡：我们在大流行病防备方面吸取教训了吗？

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-08-31 DOI: 10.1016/j.nmni.2024.101476

Faithful Miebaka Daniel, Victoria Ezinne Emeruwa, Lydia Daopuye

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

New Microbes and New Infections

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀