New Microbes and New Infections最新文献

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Disparities in response to mRNA SARS-CoV-2 vaccines according to sex and age: A systematic review 根据性别和年龄对mRNA SARS-CoV-2疫苗反应的差异：一项系统综述

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-02-01 DOI: 10.1016/j.nmni.2024.101551

Michelle Bachmann , Nejla Gültekin , Zeno Stanga , Jan S. Fehr , Ismail I. Ülgür , Patricia Schlagenhauf

Background

The rapid development and distribution of mRNA COVID-19 vaccines has been essential in containing the SARS-CoV-2 epidemic around the globe. For ongoing and future immunization campaigns globally, there is a need to evaluate the impact of population demographics such as age and sex, on vaccine efficacy and safety.

Methods

This systematic review (PROSPERO ID CRD42023328245) conducted according to PRISMA guidelines evaluates the impact of age and sex on the safety and efficacy of the mRNA COVID-19 vaccinations administrated in 15 studies that were chosen according to strict criteria. The ROBIS tool was applied to evaluate the robustness and the quality of the studies included in the review.

Results

After screening, 15 studies satisfied the inclusion criteria. The results showed that the COVID-19 mRNA vaccines typically elicit robust immune responses, and that younger people have higher antibody levels. Comparing the sexes reveals that higher immunological responses were induced in females, and mild to moderate adverse effects (such as injection site discomfort, exhaustion, and headaches) were also more frequently reported in women. Despite these variations, COVID-19 vaccines have been found to be safe to use across diverse populations, which supports their extensive use in public health initiatives.

Conclusion

Our results suggests that tailored vaccination may achieve maximum effectiveness and better tolerability depending on age and sex. Currently study results are rarely stratified by age and sex and this is a deficit in clinical trial publications. More research is needed to elucidate the biological mechanisms underlying the variations in vaccine responses according to age and sex.

背景：mRNA - COVID-19疫苗的快速开发和分发对于遏制全球SARS-CoV-2流行至关重要。对于全球正在进行和未来的免疫运动，有必要评估年龄和性别等人口统计数据对疫苗效力和安全性的影响。方法：本系统综述（PROSPERO ID CRD42023328245）按照PRISMA指南进行，评估年龄和性别对15项研究中mRNA COVID-19疫苗接种安全性和有效性的影响，这些研究根据严格的标准选择。应用ROBIS工具评价纳入本综述的研究的稳健性和质量。结果：经筛选，15项研究符合纳入标准。结果表明，COVID-19 mRNA疫苗通常会引发强大的免疫反应，年轻人的抗体水平更高。性别比较表明，女性的免疫反应更高，女性也更常报告轻微至中度的不良反应（如注射部位不适、疲惫和头痛）。尽管存在这些差异，但已发现COVID-19疫苗在不同人群中使用是安全的，这支持了它们在公共卫生行动中的广泛使用。结论：我们的研究结果表明，根据年龄和性别，量身定制的疫苗接种可能达到最大的效果和更好的耐受性。目前的研究结果很少按年龄和性别分层，这是临床试验出版物的缺陷。需要更多的研究来阐明不同年龄和性别的疫苗反应差异背后的生物学机制。

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引用次数: 0

Taenia asiatica: Mitochondrial signatures based analysis of an emerging public health threat in India

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-02-01 DOI: 10.1016/j.nmni.2024.101562

Aman D. Moudgil , Anil K. Nehra , Pallavi Moudgil

Background

Taenia asiatica is a zoonotic tapeworm, commonly known as Asian Taenia. It is an emerging sister species of T. saginata with pigs as intermediate hosts. The present study aimed at genetic characterization and population structure analysis of T. asiatica metacestodes in slaughtered pigs in Haryana, north India.

Methods

In total, the vital organs of 253 slaughtered pigs were screened for the presence of T. asiatica metacestodes. The molecular identification and phylogenetics were performed targeting the mitochondrial NADH dehydrogenase subunit 1 (nad1) and cytochrome C oxidase subunit 1 (cox1) genes. The median-joining haplotype network and population structure analyses were performed with the sequences generated herein and GenBank-archived T. asiatica sequences for both mitochondrial signatures.

Results

Out of 253 pigs screened, the liver of only one animal showed the presence of T. asiatica metacestodes. The sequences generated herein exhibited 99.60 % and 98.85 % similarity to the GenBank-archived sequences of T. asiatica corresponding to the nad1 and cox1 genes, respectively. Overall, 2 and 6 haplotypes for the overall data set with low nucleotide (0.00399 ± 0.00237 and 0.00095 ± 0.00042) and low haplotype (0.400 ± 0.237 and 0.131 ± 0.054) diversities were recorded for the nad1 and cox1 genes, respectively. The negative values recorded for the neutrality indices exhibited deviations from neutrality and hence, propounded recent population expansion or purifying selection or selective sweep.

Conclusions

The findings of the present study are of significant medical importance considering an emerging global public health threat of the neglected tapeworm T. asiatica.

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引用次数: 0

The surge of human metapneumovirus (hMPV) cases in China and global implications

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-02-01 DOI: 10.1016/j.nmni.2025.101563

Jaffar A. Al-Tawfiq , Ziad A. Memish

引用次数: 0

First reported breast implant infection due to Coxiella burnetii near an aerodrome in Southern France 在法国南部的一个机场附近首次报道了因伯纳氏科希菌引起的乳房植入物感染。

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-02-01 DOI: 10.1016/j.nmni.2024.101558

Magali Le Brun, Pierre Dudouet, Marie Laure Pelletier Louis, Piseth Seng, Andreas Stein

引用次数: 0

Pulmonary disease caused by Mycobacterium marseillense in Colombia

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-01-28 DOI: 10.1016/j.nmni.2025.101566

Darío Sebastián López-Delgado , Gabriel Alonso Rodríguez-Caicedo , Diego Fernando Taramuel-Gómez , Peter Houck , Martha Isabel Murcia-Aranguren , Roberto C. Arduino , Alfonso J. Rodriguez-Morales

引用次数: 0

Removal notice to “The possible threat of zoonotic diseases from stray dogs in Nepal” [New Microb. New Infect. 55C (2023) 101185]

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2025-01-21 DOI: 10.1016/j.nmni.2025.101565

Krishna Prasad Acharya , Saurav Pantha

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

This article has been removed at the request of the Editor-in-Chief for legal reasons.

引用次数: 0

Inaccurate communication in health sciences: The case of ‘partial artemisinin resistance’ for the treatment of malaria 卫生科学领域传播不准确：治疗疟疾的“部分青蒿素耐药性”案例。

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-12-01 DOI: 10.1016/j.nmni.2024.101544

T. Hanscheid , Sara M. Mahomed , Maria Rebelo , Susana Oliveira Henriques , Martin P. Grobusch

Background

Accurate scientific terminology is crucial in health sciences to avoid misinterpretations. The use of ‘artemisinin resistance’ to describe delayed parasite clearance may be inaccurately equated with full resistance, as is typically the case when ‘resistance’ is used with other pathogens, leading to potential confusion. In 2018, the World Health Organization (WHO) introduced ‘partial artemisinin resistance’ to more accurately reflect the delayed parasite clearance observed with artemisinin-based therapies.

Methods

We analyzed whether articles in PubMed accurately convey the concept of ‘partial artemisinin resistance’ using GPT-4 to generate related search terms. AntConc was employed for corpus analysis of retrieved articles to examine terminology in titles and abstracts. A manual review evaluated the use of the WHO concept of ‘partial artemisinin resistance’ in the full text of a subset of high-impact articles.

Results

Out of 4041 articles retrieved, only 7 % (n = 281) used ‘partial’ or ‘delayed’ in titles or abstracts. Even after 2018, when WHO introduced the term ‘partial artemisinin resistance’, only 10 % of articles included this. Manual analysis of 161 full-text articles revealed that 94 % did not use ‘partial artemisinin resistance’, and 59 % did not explain the concept of delayed parasite clearance.

Conclusion

The delayed introduction of the term ‘partial artemisinin resistance’ may have contributed to continued use of the scientifically questionable term ‘artemisinin resistance’. This term may be misunderstood as full resistance, as is common with antibiotic resistance. Accurate terminology is essential for clear scientific communication, and precise terms should be established and consistently used from the outset by scientists and clinicians.

背景：在卫生科学中，准确的科学术语对于避免误解至关重要。使用“青蒿素耐药性”来描述寄生虫清除延迟可能不准确地等同于完全耐药性，就像将“耐药性”用于其他病原体时的典型情况一样，从而导致潜在的混淆。2018年，世界卫生组织（世卫组织）引入了“部分青蒿素耐药性”，以更准确地反映以青蒿素为基础的疗法观察到的寄生虫清除延迟。方法：我们使用GPT-4生成相关搜索词，分析PubMed中的文章是否准确传达了“部分青蒿素耐药性”的概念。使用AntConc对检索到的文章进行语料库分析，检查标题和摘要中的术语。一项人工审查评估了在世卫组织“部分青蒿素耐药性”概念在一组高影响力文章全文中的使用情况。结果：在检索到的4041篇文章中，只有7% （n = 281）在标题或摘要中使用了“部分”或“延迟”。即使在2018年世卫组织引入“部分青蒿素耐药性”一词之后，也只有10%的文章包含了这一术语。对161篇全文的人工分析显示，94%的文章没有使用“部分青蒿素耐药性”，59%的文章没有解释延迟寄生虫清除的概念。结论：延迟引入“部分青蒿素耐药性”一词可能导致继续使用科学上有问题的术语“青蒿素耐药性”。这个术语可能被误解为完全耐药，就像抗生素耐药一样。准确的术语对于清晰的科学交流至关重要，科学家和临床医生应该从一开始就建立和一贯使用精确的术语。

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引用次数: 0

A novel multidrug-resistant Enterobacter hormaechei ST2755 isolated from a wild-caught oyster in Georgia, USA 从美国乔治亚州野生捕获的牡蛎中分离出一种新的多重耐药霍氏肠杆菌ST2755。

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-12-01 DOI: 10.1016/j.nmni.2024.101546

Nivin A. Nasser, Marwan Osman, Jouman Hassan, Tongzhu Xu, David Mann, Xiangyu Deng, Issmat I. Kassem

引用次数: 0

Scrub typhus with urinary tract infection and leukopenia: A case series 恙虫病伴尿路感染和白细胞减少：一个病例系列。

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-12-01 DOI: 10.1016/j.nmni.2024.101548

Cuiping Wu , Miao Lu , Xuejun Dong, Yitong Jiang, Bo Liang, Kun Li

引用次数: 0

Mpox emerges in Zimbabwe: A turning point in global health vigilance 津巴布韦出现麻疹：全球卫生警戒的转折点。

IF 2.9 Q2 INFECTIOUS DISEASES

New Microbes and New Infections

Pub Date : 2024-12-01 DOI: 10.1016/j.nmni.2024.101542

Chelsea Rachael Tafawa, Manvinder Brar, Sanjit Sah, Rachana Mehta, Ganesh Bushi, Ashok Kumar Balaraman, Sakshi Pandey, Amogh Verma

引用次数: 0

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