Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Microencapsulation of Fridericia chica extract: stability, anthocyanin retention, and antioxidant properties for food and therapeutic applications","authors":"Vitória Ribeiro Garcia de Figueiredo Muniz ,&nbsp;Ailane Souza de Freitas ,&nbsp;Luan da Silva Dias Rabelo ,&nbsp;Luís Felipe Perdigão Rodrigues ,&nbsp;Karina Rodrigues Honorato ,&nbsp;Ana Carolina Rorato ,&nbsp;Ana Lúcia Tasca Gois Ruiz ,&nbsp;Ilza Maria de Oliveira Sousa ,&nbsp;Luciana Igarashi-Mafra ,&nbsp;Mary Ann Foglio ,&nbsp;Alvaro Luiz Mathias ,&nbsp;Marcos R. Mafra","doi":"10.1016/j.bcdf.2025.100483","DOIUrl":"10.1016/j.bcdf.2025.100483","url":null,"abstract":"<div><h3>Relevance</h3><div><em>Fridericia chica</em> (Bonpl.) L.G. Lohmann (syn. <em>Arrabidaea chica</em> Verlot) is a medicinal plant traditionally utilized by Indigenous communities and local populations in the Amazon and tropical South America for its antioxidant, anti-inflammatory, and anticancer activities, attributed to its anthocyanin-rich composition.</div></div><div><h3>Aim of the study</h3><div>To enhance aqueous infusion extraction of processed <em>F. chica</em> leaves to maximize anthocyanin content and stabilize bioactive compounds through microencapsulation via spray drying.</div></div><div><h3>Materials and methods</h3><div>Mineral water acidified with varying concentrations of Tahiti lemon juice was used to extract bioactive compounds. The extract with the highest anthocyanin content was microencapsulated using maltodextrin or Arabic gum as protective matrices. High-Performance Liquid Chromatography (470 nm detector) identified key anthocyanidins (hydroxycarajurone, carajurone, carajurin). Total phenolic compounds (TPC), total flavonoid compounds (TFC), and antioxidant properties (ABTS, DPPH, FRAP) were assessed over 180 days under refrigerated (4 °C) and room temperature (25 °C) storage conditions.</div></div><div><h3>Results</h3><div>The extract microparticles (FEC, control) showed significant degradation in bioactive content (88 % reduction in TPC, 35 % in TFC). Microencapsulation improved stability: Microcapsules with maltodextrin (FEMM) exhibited a 7.15 % loss of total phenolic content (TPC) and a 10.22 % loss of total flavonoid content (TFC), whereas microcapsules with gum Arabic (FEMA) showed minimal loss of TPC (0.74 %) and an 11.66 % reduction of TFC. Refrigeration mitigated degradation, and Arabic gum had better-preserved antioxidant activity than maltodextrin under both conditions.</div></div><div><h3>Conclusions</h3><div>Microencapsulation significantly enhanced the stability of <em>F. chica</em> bioactive compounds, with Arabic gum outperforming maltodextrin. These powders demonstrate high potential as functional food ingredients, offering stability, antioxidant preservation, and suitability for extended storage.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100483"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative insights into carbohydrate-coated gold nanoparticle-based drug delivery vehicles for QSAR advancement: Calorimetric and mechanistic studies","authors":"Vishakha Choudhary,&nbsp;Aditi Pandey,&nbsp;Bhawna Sharma,&nbsp;Achal Mukhija","doi":"10.1016/j.bcdf.2025.100484","DOIUrl":"10.1016/j.bcdf.2025.100484","url":null,"abstract":"<div><div>Quantitative structure-activity relationship (QSAR) analysis is essential for the development of effective drug delivery vehicles in the era of Artificial Intelligence (AI). To develop this QSAR, carbohydrates with different structural features have been used to coat and make biocompatible gold nanoparticles. These carbohydrate-coated gold nanoparticles have been synthesized by chemical reduction method and characterized by UV–vis, FT-IR, DLS, and SEM techniques. For quantitative study, the interaction of these nanoparticles has been studied with biological interfaces (protein and DNA) and their structural features have correlated with thermodynamic parameters; binding constant, Gibbs free energy, enthalpy, and entropy obtained from calorimetry and fluorescence technique. To elucidate the effect of coating of carbohydrates on gold nanoparticles, interaction studies have also been done with pure carbohydrates and compared with carbohydrate-coated gold nanoparticles. For activity-relationship, these quantitative parameters have been correlated with the therapeutic efficiency of these nanoparticles in terms of drug loading and drug release studies with 5-fluorouracil (5-FU) drugs. The results suggest the importance of the CHO functional group and also the number of monomeric units in interaction studies and therapeutic efficiency. Energetics of interaction correlated with physical characteristics of different carbohydrates develop the structure-activity relationship, which assists in the development of highly effective AI-based future drug delivery vehicles.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100484"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterococcus hirae OL616073 glucan exopolysaccharide based cumin oil emulsion: Characterization and antibacterial activity","authors":"Swati Tiwari ,&nbsp;Digambar Kavitake ,&nbsp;Palanisamy Bruntha Devi ,&nbsp;Irshad Ahmad Shah ,&nbsp;Prathapkumar Halady Shetty","doi":"10.1016/j.bcdf.2025.100480","DOIUrl":"10.1016/j.bcdf.2025.100480","url":null,"abstract":"<div><div>This study aims to prepare the cumin essential oil-based emulsion stabilized by glucan exopolysaccharide (EPS) from <em>Enterococcus hirae</em> OL616073. The emulsion was prepared by optimizing different ratios of EPS to essential oil via vortexing, ultrasonication, and high shear homogenization. The concentration of EPS (among 0.5, 1, 1.5, and 2 %) and the ratio of EPS to essential oil (among 1:0.5, 1:1, 1:1.5, and 1:2) were initially optimized using vortexing. Ultrasonication and high shear homogenization processes were applied to the vortexed samples and optimized the concentration of EPS and the ratio of EPS to essential oil combinations. The emulsion capacity, emulsion stability, the effect of various processing parameters (temperature and salt), and antimicrobial activity were determined for the emulsions prepared from vortexing, ultrasonication, and high shear homogenization. It was found that emulsion capacity and emulsion stability were better in ultrasonication and high shear homogenization treatment compared to vortexing. When these emulsions were treated with various temperatures and the effect of ionic strengths, the order of emulsion stability was recorded as ultrasonication &gt; high shear homogenization &gt; vortexing. Further, there was significant antimicrobial activity against four tested pathogens, namely <em>Listeria monocytogenes</em> (MTCC 1143), <em>S. aureus</em> (MTCC 1144), <em>E. coli</em> (MTCC 433), and <em>Shewanella putrefaciens</em> (MTCC 8104), but no antimicrobial activity against <em>Salmonella enterica</em> (950) was observed. Parameters such as type of emulsion, turbidity, pH, Fourier transform infrared (FT-IR) analysis, and microscopic analyses were also performed for emulsions. This EPS-based emulsion system can be further explored for functional applications in the field of food and health.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic synthesis of analogous human milk oligosaccharide and its prebiotic attributes","authors":"Jayashree Niharika,&nbsp;Bhoomi Italiya,&nbsp;Ravindra Pal Singh","doi":"10.1016/j.bcdf.2025.100479","DOIUrl":"10.1016/j.bcdf.2025.100479","url":null,"abstract":"<div><div>Human milk oligosaccharides (HMOs) are the third most abundant component of human milk and deliver a myriad of benefits to infants including inhibiting the growth of pathogens and promoting the population of <em>Bifidobacterium</em>. In this study, glycoside hydrolase family 94 (GH94) member cellodextrin phosphorylase (CDP) has been used to synthesize a trisaccharide (Gal-β-1,4-Gal-β-1,4-Glc) in milligrams by transferring a galactose unit on cellobiose that mimics the primary building block of HMOs. Previous study of saturation transfer difference nuclear magnetic resonance spectroscopy indicated that the phosphate group of glucose-1-phosphate (Glc-1-P) makes hydrogen bonds with the side chain of H817, R486 and S889, and the backbone of G890, as well as a salt bridge with R486. We employed site-directed mutagenesis to determine the roles of these residues in synthesizing analogue HMO using galactose-1-phosphate (Gal-1-P). We did alanine scanning of these residues and found that mutation of R486A and G890A residues led to enzyme inactivation. Whilst mutation in H817A and S889A residues led to decreased enzymatic activity. These results further suggested that Gal-1-P bound at the donor site similar to a cognate donor (Glc-1-P). Using the native CDP, 40 mg of analogue HMO trisaccharide was produced with a 66 % yield. The product was well purified and analytically characterized. This trisaccharide is found to support the growth of probiotic bacteria such as <em>Bifidobacterium longum, Roseburia faecis,</em> and <em>Blautia producta</em>.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100479"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For cereal bran, rating of antioxidant capacity and screening of xanthine oxidase inhibitor","authors":"Ye Lou,&nbsp;Ming Cong Fan,&nbsp;Li Wang,&nbsp;Yan Li,&nbsp;Haifeng Qian","doi":"10.1016/j.bcdf.2025.100476","DOIUrl":"10.1016/j.bcdf.2025.100476","url":null,"abstract":"<div><div>Based on the free radical scavenging rate and xanthine oxidase (XOD) inhibition rate, the basic properties of different cereal bran were analyzed, and the key XOD inhibitor in bran extract was screened by ultrafiltration centrifugation combined with liquid chromatography. The effectiveness of ferulic acid (FA) in the regulation of hyperuricemia was evaluated by basic physiological indexes, expression of inflammatory factors and expression of urate transporter. The analysis of the basic properties of maize bran showed that the free phenol content of maize bran is 221.17 ± 8.03 mg GAE/100 g DW, and the bound phenol content is 245.88 ± 5.31 mg GAE/100 g DW, which is the highest among five kinds of cereal bran. The antioxidant capacity of bran was evaluated according to ABTS free radical scavenging rate and DPPH free radical scavenging rate. The IC₅₀ value of maize bran bound phenol was 0.23 μg/mL for ABTS and 2.76 μg/mL for DPPH. Eight potential XOD inhibitors were detected in maize bran bound phenol and among which FA had the highest XOD inhibition rate. Animal experiments demonstrated that FA could effectively alleviate slow weight gain, suppress the increased expression of inflammatory factors, and correct the abnormal expression of urate transporters in hyperuricemia-induced mice. The results can provide a basis that cereal bran as a dietary supplement and functional food take hyperuricemia regulation effect in the future.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100476"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims and Scope & Editorial Board","authors":"","doi":"10.1016/S2212-6198(25)00011-7","DOIUrl":"10.1016/S2212-6198(25)00011-7","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100477"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Characterization and antioxidant activity of flaxseed mucilage and evaluation of its dietary supplementation in improving calcium absorption in vivo” [Journal: Bioactive Carbohydrates and Dietary Fibre 32 (2024) 100444]","authors":"Engy M. Akl ,&nbsp;Rasha S. Mohamed ,&nbsp;Sherein S. Abdelgayed ,&nbsp;Karem Fouda ,&nbsp;Mosaad A. Abdel-Wahhab","doi":"10.1016/j.bcdf.2025.100471","DOIUrl":"10.1016/j.bcdf.2025.100471","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100471"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The specificity of family 4 carbohydrate-binding modules (CBMs) of BpGH16MLG influences the binding and utilization of β-glucans in a human gut bacterium, Blautia producta","authors":"Harshita Gupta ,&nbsp;Chandani Gajera ,&nbsp;Prachi Kumari,&nbsp;Ravindra Pal Singh","doi":"10.1016/j.bcdf.2025.100475","DOIUrl":"10.1016/j.bcdf.2025.100475","url":null,"abstract":"<div><div>Several thousand bacterial communities reside in the human gut environment and have acquired numerous genes during co-evolution for trapping dietary nutrients. Many of Gram-positive bacteria encode extracellular cell wall membrane-bound endolytic enzymes with non-catalytic carbohydrate-binding modules (CBMs) that recognize cognate glycan(s). Much remains unknown about how these organisms recognize nutrients in the gut environment. <em>Blautia producta</em> JCM 1471^T expresses a cell membrane-tethered endo-acting enzyme (<em>Bp</em>GH16_MLG-digesting barley-β-glucan, lichenan, and laminarin) with four carbohydrate-binding modules (CBM4_1, CBM4_2, CBM4_3, and CBM4_4). Each CBM4 and its dual combinations were cloned, characterized, and assessed with three distinct β-glucans (barley-β-glucan, lichenan, and laminarin). It was observed that each CBM4 recognizes barley-β-glucan and lichenan with approximately equal affinity. Dual combination, CBM4_1-CBM4_2 exhibited a substantial predilection for barley-β-glucan, whereas CBM4_3-CBM4_4 had an affinity for barley-β-glucan and lichenan. None of the dual combinations showed an affinity for laminarin. Intriguingly, a mutant (E384A-catalytic base) version of <em>Bp</em>GH16_MLG with all CBM4 domains showed high binding to barley-β-glucans and lichenan, but moderate binding to laminarin. This understanding provides insights into how <em>B. producta</em> recognizes and likely traps specific nutrient in the gut environment. Furthermore, the study may have implications for the development of innovative biocatalysis.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100475"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring potential of aloe vera and sterculia gum dietary fibers to develop functional hydrogels for drug delivery applications","authors":"Diwanshi Sharma,&nbsp;Baljit Singh","doi":"10.1016/j.bcdf.2025.100474","DOIUrl":"10.1016/j.bcdf.2025.100474","url":null,"abstract":"<div><div>Now days the main focus of carbohydrate research is to design functional hydrogels for biomedical applications. The aloe vera (AV) and sterculia gum (SG) are therapeutically active dietary fibers. Herein, these polysaccharides were explored to develop network hydrogels by covalent and non-covalent interactions for use in drug delivery (DD) and wound dressing (WD) applications. These hydrogel dressings were impregnated with antibiotic drug moxifloxacin for better wound care. Slow and sustained diffusion of drug was found with a non-Fickian mechanism and release profile was best explained by Higuchi kinetic model. Additionally, various physiological and biomedical properties of hydrogels were also evaluated. The dressings exhibited an impressive wound fluid absorption tendency under simulated conditions. The network structure demonstrated mucoadhesive properties and required 97 ± 6.00 mN forces for the detachment of dressings from mucosal surface. Dressing revealed significant antioxidant activity which demonstrated 49.14 ± 0.32 % free radical scavenging in DPPH assay. The dressings were non-toxic and were permeable to O₂ &amp; H₂O. The characterization of hydrogel dressings was performed through Field emission scanning electron microscopy/Energy dispersive spectroscopy (FESEM/EDS), Atomic force microscopy (AFM), ¹³Carbon Nuclear magnetic resonance spectroscopy (¹³C NMR), Fourier transform infrared spectroscopy (FTIR) &amp; X-ray diffraction (XRD) techniques to establish the structural aspects of copolymers. Overall, physicochemical &amp; biochemical findings suggested that these hydrogels could be applied in DD applications. These hydrogels developed from bioactive AV and SG could be applied as wound dressings encapsulated with antibiotic drug for better wound healing.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100474"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary prebiotic combination improves immunological and hematological parameters in weaned pigs","authors":"Patrícia Versuti Arantes Alvarenga ,&nbsp;Vinicius Ricardo Cambito de Paula ,&nbsp;Mayra Anton Dib Saleh ,&nbsp;Silvia Letícia Ferreira ,&nbsp;Filipe Garcia Telles ,&nbsp;Ricardo de Oliveira Orsi ,&nbsp;Carlos Roberto Padovani ,&nbsp;Urbano dos Santos Ruiz ,&nbsp;Marcos Livio Panhoza Tse","doi":"10.1016/j.bcdf.2025.100473","DOIUrl":"10.1016/j.bcdf.2025.100473","url":null,"abstract":"<div><div>As antimicrobial resistance is a global public health problem and as known the use of prebiotics on animal nutrition have antimicrobial effects, we hypothesized the use of prebiotic additives can be an alternative to in-feed antibiotics for piglets to control sanitary challenge. Thus, the aim of this study was to evaluate the inclusion of prebiotics mannan<strong>-</strong>oligosaccharide (MOS), β-glucan, fructooligosaccharide (FOS) and galacto-oligosaccharides (GOS) to replace antibiotics as growth promoters, on immunological and hematological parameters of 21d-old weaned pigs challenged with intramuscular injection of 30 μg kg⁻¹ body weight of <em>Escherichia coli</em> lipopolysaccharide (LPS). Forty weaned piglets (7.2 kg) fed: CON = basal diet (BD) plus 120 ppm of halquinol; Mβ = BD plus a blend of MOS and β-glucan; F₉G₁ = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 9:1); F₇G3 = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 7:3); F₅G₅ = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 5:5). After LPS challenge, the animals fed F₉G₁ had higher hydrogen peroxide (H₂O₂) and the same nitric oxide (NO) serum concentration than CON. Animals fed Mβ and F₉G₁ showed similar serum C-reactive protein (CP) concentration than CON and serum cytokine tumor necrosis factor alpha (TNF-α) concentration were higher in animals fed F₉G₁ or F₅G₅ than CON. In general, we concluded that treatment F₉G₁, is better for immune response during immunological challenge, because more effective immunological variables were affected (H₂O₂, NO, CP and TNF-α).</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}