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Etiological diagnosis of myocarditis: an unresolved issue? 心肌炎的病因诊断:一个尚未解决的问题?
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-09-02 DOI: 10.1016/j.rec.2025.09.001
Fernando Domínguez
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引用次数: 0
Perceptions of the Spanish population regarding various public health measures to control tobacco use. 西班牙民众对控制烟草使用的各种公共卫生措施的看法。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-09-02 DOI: 10.1016/j.rec.2025.06.012
Julia Rey-Brandariz, Carla Guerra-Tort, Ana Teijeiro, Lucía Rodríguez-Loureiro, Mónica Pérez-Ríos
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引用次数: 0
The invisible threat: air pollution is now the second leading risk factor for mortality in the general population 无形的威胁:空气污染现在是导致普通人群死亡的第二大风险因素。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-28 DOI: 10.1016/j.rec.2025.07.008
Alberto Domínguez-Rodríguez , Daniel Hernández-Vaquero , Néstor Baéz-Ferrer
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引用次数: 0
Registries of the Heart Rhythm Association of the Spanish Society of Cardiology: current role and future prospects 西班牙心脏病学会心律协会的注册:目前的作用和未来的前景。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-28 DOI: 10.1016/j.rec.2025.05.015
David Calvo
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引用次数: 0
Spanish pacemaker registry. 22nd official report of the Heart Rhythm Association of the Spanish Society of Cardiology (2024) 西班牙心脏起搏器登记。西班牙心脏病学会心律协会第22次正式报告(2024年)。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-28 DOI: 10.1016/j.rec.2025.07.007
Francisco Javier García-Fernández , Rocío Cózar-León , Josep Navarro-Manchón , Manuel Molina-Lerma , David Calvo , on behalf of the collaborators of the Spanish pacemaker registry

Introduction

This report presents data on cardiac pacing system implants in Spain during 2024.

Methods

The registry is based on data voluntarily submitted by implanting centers to the Heart Rhythm Association of the Spanish Society of Cardiology via the national online platform, CardioDispositivos. Additional data sources included: a) data provided by device manufacturers and distributors, b) the European pacemaker patient card, and c) local databases submitted by implanting centers.

Results

A total of 128 hospitals submitted data to the registry (16 more than in 2023 and 46 more than in 2022). In total, 26 412 units were reported (an 8.5% increase compared with 2023 and 60.8% compared with 2022), vs 47 162 units reported by Eucomed (European Confederation of Medical Suppliers Associations). Among these, 1715 were cardiac resynchronization pacemakers. Leadless pacemaker use continued to rise (1049 devices), accounting for 2.2% of all pacemakers. The most common indication was atrioventricular block, followed by atrial tachyarrhythmia with slow ventricular response. Devices included in remote monitoring also increased: the most notable growth was observed in high-energy resynchronization devices (87%) and leadless pacemakers (38%). Moderate increases were also noted for conventional cardiac resynchronization pacemakers (59%) and standard pacemakers (39%).

Conclusions

Participation in the pacemaker registry continues to grow, reaching 56% of the number of units reported by manufacturers to Eucomed. Remote monitoring maintains the slow but steady growth trend observed in recent years.
本报告介绍了2024年西班牙心脏起搏系统植入的数据。方法:注册表基于植入中心通过国家在线平台CardioDispositivos自愿提交给西班牙心脏病学会心律协会的数据。其他数据来源包括:a)设备制造商和经销商提供的数据,b)欧洲起搏器患者卡,以及c)植入中心提交的本地数据库。结果:共有128家医院向登记处提交了数据(比2023年增加16家,比2022年增加46家)。总共报告了26412个单位(与2023年相比增长8.5%,与2022年相比增长60.8%),而Eucomed(欧洲医疗供应商协会联合会)报告了47162个单位。其中心脏再同步起搏器1 715例。无铅起搏器的使用持续上升(1049台),占所有起搏器的2.2%。最常见的适应症是房室传导阻滞,其次是房性心动过速伴心室反应缓慢。远程监控设备也有所增加:最显著的增长是高能再同步设备(87%)和无铅起搏器(38%)。常规心脏再同步起搏器(59%)和标准起搏器(39%)也有中度增加。结论:参与起搏器登记的人数持续增长,达到制造商向Eucomed报告的单位数量的56%。远程监测维持了近年来观察到的缓慢但稳定的增长趋势。完整的英文文本可从:www.revespcardiol.org/en。
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引用次数: 0
Hypertrophic cardiomyopathy with sequential intracavitary obstruction resolved by mavacamten 肥厚性心肌病伴序贯腔内梗阻由马伐卡坦治疗。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-27 DOI: 10.1016/j.rec.2025.08.001
Margarida G. Figueiredo, José Miguel Viegas, Sílvia Aguiar Rosa
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引用次数: 0
Impact of fine particulate matter (PM2.5) pollution on hospital admissions and mortality due to acute myocardial infarction in Spain 细颗粒物(PM2.5)污染对西班牙急性心肌梗死住院率和死亡率的影响
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-19 DOI: 10.1016/j.rec.2025.06.011
Raquel Campuzano , Julio Núñez , Violeta Sánchez , Juan José Gómez-Doblas , Vicente Arrarte , Ángel Cequier , Blanca Miranda , Cristina Fernández , Náyade Prado , Nicolás Rosillo , José Luis Bernal , Pablo Pérez , Sonia Gutiérrez , Jordi Bañeras

Introduction and objectives

Atherosclerotic vascular disease is the main cause of mortality attributable to air pollution. This study analyzes, for the first time, the association between levels of fine particulate matter (PM2.5, particles ≤ 2.5 μm in diameter) and hospital admissions and in-hospital mortality due to acute myocardial infarction (AMI) in hospitals of the Spanish National Health System.

Methods

Data on air pollution, temperature, and humidity were obtained from the Ministry for the Ecological Transition and the Demographic Challenge, covering the period from 2016 to 2021. A total of 122 National Health System hospitals were geographically matched with environmental monitoring stations located within a 10 km radius. The study included 115 071 patients aged 18 years or older (mean age, 67 years; 28% women) who were discharged with a diagnosis of AMI during the study period. An autoregressive integrated moving average (ARIMA) model was applied to each hospital, and a meta-analysis was conducted to consolidate the estimates of the association between PM2.5 levels and variations in AMI hospital admissions. The association between PM2.5 pollution and in-hospital AMI mortality was analyzed using logistic regression models.

Results

Maximum 3-day average PM2.5 levels exceeding 10 μg/m3 were associated with an additional 21.9 AMI hospital admissions per 1000 (95%CI, 9.1-34.8; P < .001). Furthermore, PM2.5 levels above 25 μg/m3 (3-day moving average) were associated with an increased risk of in-hospital mortality due to AMI (OR, 1.14; 95%CI, 1.07-1.23; P < .001).

Conclusions

This study identifies a significant association between elevated PM2.5 levels and increased hospital admissions and in-hospital mortality due to AMI in Spain, highlighting the importance of reducing air pollution as a critical factor in cardiovascular health.
简介和目的:动脉粥样硬化性血管疾病是空气污染导致死亡的主要原因。本研究首次分析了西班牙国家卫生系统医院细颗粒物(PM2.5,直径≤2.5μm的颗粒)水平与急性心肌梗死(AMI)住院率和住院死亡率之间的关系。方法:从生态转型和人口挑战部获得2016年至2021年期间的空气污染、温度和湿度数据。共有122家国家卫生系统医院在地理上与10公里半径内的环境监测站相匹配。该研究纳入了115071例18岁及以上的患者(平均年龄67岁,28%为女性),这些患者在研究期间因AMI诊断出院。对每家医院应用自回归综合移动平均(ARIMA)模型,并进行荟萃分析,以巩固PM2.5水平与急性心肌梗死住院率变化之间的关联。采用logistic回归模型分析PM2.5污染与AMI住院死亡率之间的关系。结果:PM2.5浓度超过10μg/m3的最大3天平均值与每1000人中额外的21.9例AMI住院相关(95%CI, 9.1-34.8); PM2.5浓度超过25μg/m3(3天移动平均值)与AMI住院死亡风险增加相关(OR, 1.14; 95%CI, 1.09 -1.23;结论:本研究确定了PM2.5水平升高与西班牙AMI住院率和住院死亡率增加之间的显著关联,强调了减少空气污染作为心血管健康的关键因素的重要性。
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引用次数: 0
Refractory congestion in heart failure: when standard therapies fall short 心力衰竭的难治性充血:当标准治疗不足时。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-14 DOI: 10.1016/j.rec.2025.06.010
Rafael de la Espriella
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引用次数: 0
Physical activity in patients with atrial fibrillation and adverse outcomes: results from a large-scale prospective multicenter European cohort 房颤患者的身体活动和不良后果:来自欧洲一项大规模前瞻性多中心队列研究的结果
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-13 DOI: 10.1016/j.rec.2025.07.005
Marco Vitolo , Marco Proietti , Marta Mantovani , Jacopo Francesco Imberti , Davide Antonio Mei , Niccolò Bonini , Giulio Francesco Romiti , Bernadette Corica , Igor Diemberger , Laurent Fauchier , Francisco Marín , Gheorghe-Andrei Dan , Tatjana S. Potpara , Gregory Y.H. Lip , Giuseppe Boriani

Introduction and objectives

Increased physical activity may improve outcomes in patients with atrial fibrillation (AF), but available data are limited. This study aimed to analyze the association between physical activity and major adverse outcomes in a large European AF cohort.

Methods

We used data from a prospective, observational, large-scale multicenter study of AF in European patients, involving 27 countries and 250 centers. Patients self-reported their physical activity levels during the preceding 2 years, categorized as none (physically inactive), occasional, regular, or intense. The primary outcome was a composite of major adverse cardiovascular (CV) events and all-cause mortality.

Results

A total of 9525 patients with AF were included (median age 71 years; 41% female). Overall, 43% reported being physically inactive. Among those who reported physical activity, 56.9% described it as occasional, 36.5% as regular, and 6.6% as intense. Inactive patients had a higher burden of both CV and non-CV comorbidities. Over a median follow-up of 728 days, 16.2% of the patients experienced the primary composite endpoint. Physical activity was independently associated with a lower risk of the primary endpoint (adjusted HR, 0.68; 95% CI, 0.59-0.76), with a progressively lower incidence as activity levels increased. Interaction analyses showed that the beneficial effect of physical activity was consistent among several subgroups, with no significant interactions.

Conclusions

Physical activity, even at low levels, was associated with a reduced incidence of CV events and all-cause mortality. These benefits appear to be independent of CV risk factors and comorbidities, highlighting the importance of incorporating physical activity into holistic AF management strategies.
简介和目的:增加体力活动可能改善心房颤动(AF)患者的预后,但现有数据有限。本研究旨在分析欧洲大型房颤队列中体力活动与主要不良后果之间的关系。方法:我们使用的数据来自一项前瞻性、观察性、大规模的多中心研究,涉及欧洲27个国家和250个中心的房颤患者。患者自我报告前2年的身体活动水平,分为无运动(不运动)、偶尔运动、定期运动或剧烈运动。主要结局是主要心血管不良事件和全因死亡率的综合结果。结果:共纳入9525例房颤患者(中位年龄71岁;41%的女性)。总体而言,43%的人表示自己缺乏体育锻炼。在报告有体育锻炼的人中,56.9%的人说自己偶尔运动,36.5%的人说自己经常运动,6.6%的人说自己剧烈运动。不运动的患者有更高的CV和非CV合并症负担。在中位728天的随访中,16.2%的患者达到了主要的复合终点。体力活动与较低的主要终点风险独立相关(调整后HR, 0.68;95% CI, 0.59-0.76),随着活动水平的增加,发病率逐渐降低。相互作用分析表明,体育活动的有益效果在几个亚组中是一致的,没有显著的相互作用。结论:体力活动,即使是低水平的体力活动,也与降低心血管事件发生率和全因死亡率相关。这些益处似乎与心血管危险因素和合并症无关,强调了将体育活动纳入房颤整体管理策略的重要性。
{"title":"Physical activity in patients with atrial fibrillation and adverse outcomes: results from a large-scale prospective multicenter European cohort","authors":"Marco Vitolo ,&nbsp;Marco Proietti ,&nbsp;Marta Mantovani ,&nbsp;Jacopo Francesco Imberti ,&nbsp;Davide Antonio Mei ,&nbsp;Niccolò Bonini ,&nbsp;Giulio Francesco Romiti ,&nbsp;Bernadette Corica ,&nbsp;Igor Diemberger ,&nbsp;Laurent Fauchier ,&nbsp;Francisco Marín ,&nbsp;Gheorghe-Andrei Dan ,&nbsp;Tatjana S. Potpara ,&nbsp;Gregory Y.H. Lip ,&nbsp;Giuseppe Boriani","doi":"10.1016/j.rec.2025.07.005","DOIUrl":"10.1016/j.rec.2025.07.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Increased physical activity may improve outcomes in patients with atrial fibrillation (AF), but available data are limited. This study aimed to analyze the association between physical activity and major adverse outcomes in a large European AF cohort.</div></div><div><h3>Methods</h3><div>We used data from a prospective, observational, large-scale multicenter study of AF in European patients, involving 27 countries and 250 centers. Patients self-reported their physical activity levels during the preceding 2 years, categorized as none (physically inactive), occasional, regular, or intense. The primary outcome was a composite of major adverse cardiovascular (CV) events and all-cause mortality.</div></div><div><h3>Results</h3><div>A total of 9525 patients with AF were included (median age 71 years; 41% female). Overall, 43% reported being physically inactive. Among those who reported physical activity, 56.9% described it as occasional, 36.5% as regular, and 6.6% as intense. Inactive patients had a higher burden of both CV and non-CV comorbidities. Over a median follow-up of 728 days, 16.2% of the patients experienced the primary composite endpoint. Physical activity was independently associated with a lower risk of the primary endpoint (adjusted HR, 0.68; 95% CI, 0.59-0.76), with a progressively lower incidence as activity levels increased. Interaction analyses showed that the beneficial effect of physical activity was consistent among several subgroups, with no significant interactions.</div></div><div><h3>Conclusions</h3><div>Physical activity, even at low levels, was associated with a reduced incidence of CV events and all-cause mortality. These benefits appear to be independent of CV risk factors and comorbidities, highlighting the importance of incorporating physical activity into holistic AF management strategies.</div></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 2","pages":"Pages 151-164"},"PeriodicalIF":4.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cumulative resting heart rate load and cardiovascular risk in patients with heart failure in sinus rhythm. 窦性心律心力衰竭患者的累积静息心率负荷与心血管风险。
IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-08-13 DOI: 10.1016/j.rec.2025.07.006
Jun Hao, Jingyang Wang, Rui Shi, Qi Wang, Xiaohua Cheng, Jiayu Feng, Yanmin Yang, Yuxiao Hu, Tao Chen, Kangyu Chen

Introduction and objectives: Resting heart rate is a readily available vital sign with important prognostic significance. However, traditional measures overlook both the magnitude and duration of elevated heart rate over time. This study assessed the association between cumulative resting heart rate load and adverse outcomes in patients with chronic heart failure (HF) in sinus rhythm.

Methods: Data from 5 randomized controlled trials (BEST, GUIDE-IT, HF-ACTION, RELAX, and TOPCAT) were analyzed. Cumulative heart rate load was calculated as the area under the curve (AUC) for heart rate ≥70 beats per minute (bpm), relative to the total AUC prior to outcomes. The primary outcome was major adverse cardiac events (MACE), defined as the composite of cardiovascular death and hospitalization for HF. Cox proportional hazards regression models were used to examine associations with outcomes.

Results: A total of 5428 patients were included. Higher cumulative resting heart rate load was significantly associated with increased risk of MACE (hazard ratio [HR], 1.31; 95% CI, 1.24-1.38), cardiovascular death (HR, 1.17; 95% CI, 1.08-1.27), hospitalization for HF (HR, 1.34; 95% CI, 1.26-1.43), all-cause death (HR, 1.20; 95% CI, 1.12-1.29), and any hospitalization (HR, 1.20; 95% CI, 1.15-1.25). Cumulative resting heart rate load demonstrated superior predictive value for all outcomes compared with baseline heart rate, mean heart rate, heart rate standard deviation, and heart rate time in the target range with improvements in C-statistics, net reclassification improvement, and integrated discrimination improvement when added to base models.

Conclusions: Cumulative resting heart rate load provides stronger prognostic value for adverse outcomes in chronic HF. Incorporating this parameter into clinical practice may improve risk stratification and help identify high-risk patients who could benefit from intensive monitoring or therapeutic interventions.

简介和目的:静息心率是一种容易获得的生命体征,具有重要的预后意义。然而,传统的测量方法忽略了心率随时间升高的幅度和持续时间。本研究评估了窦性心律慢性心力衰竭(HF)患者的累积静息心率负荷与不良结局之间的关系。方法:对5项随机对照试验(BEST、GUIDE-IT、HF-ACTION、RELAX、TOPCAT)的数据进行分析。累积心率负荷计算为心率≥70次/分钟(bpm)时的曲线下面积(AUC),相对于结果前的总AUC。主要终点是主要心脏不良事件(MACE),定义为心血管死亡和HF住院的综合。Cox比例风险回归模型用于检验与结果的关联。结果:共纳入5428例患者。较高的累积静息心率负荷与MACE风险增加显著相关(危险比[HR], 1.31;95% CI, 1.24-1.38),心血管死亡(HR, 1.17;95% CI, 1.08-1.27),心衰住院(HR, 1.34;95% CI, 1.26-1.43),全因死亡(HR, 1.20;95% CI, 1.12-1.29),以及任何住院治疗(HR, 1.20;95% ci, 1.15-1.25)。与基线心率、平均心率、心率标准差和心率在目标范围内的时间相比,累积静息心率负荷对所有结局的预测价值都更高(P)。结论:累积静息心率负荷对慢性心衰不良结局的预测价值更强。将这一参数纳入临床实践可以改善风险分层,并有助于识别高危患者,这些患者可以从强化监测或治疗干预中受益。
{"title":"Cumulative resting heart rate load and cardiovascular risk in patients with heart failure in sinus rhythm.","authors":"Jun Hao, Jingyang Wang, Rui Shi, Qi Wang, Xiaohua Cheng, Jiayu Feng, Yanmin Yang, Yuxiao Hu, Tao Chen, Kangyu Chen","doi":"10.1016/j.rec.2025.07.006","DOIUrl":"10.1016/j.rec.2025.07.006","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Resting heart rate is a readily available vital sign with important prognostic significance. However, traditional measures overlook both the magnitude and duration of elevated heart rate over time. This study assessed the association between cumulative resting heart rate load and adverse outcomes in patients with chronic heart failure (HF) in sinus rhythm.</p><p><strong>Methods: </strong>Data from 5 randomized controlled trials (BEST, GUIDE-IT, HF-ACTION, RELAX, and TOPCAT) were analyzed. Cumulative heart rate load was calculated as the area under the curve (AUC) for heart rate ≥70 beats per minute (bpm), relative to the total AUC prior to outcomes. The primary outcome was major adverse cardiac events (MACE), defined as the composite of cardiovascular death and hospitalization for HF. Cox proportional hazards regression models were used to examine associations with outcomes.</p><p><strong>Results: </strong>A total of 5428 patients were included. Higher cumulative resting heart rate load was significantly associated with increased risk of MACE (hazard ratio [HR], 1.31; 95% CI, 1.24-1.38), cardiovascular death (HR, 1.17; 95% CI, 1.08-1.27), hospitalization for HF (HR, 1.34; 95% CI, 1.26-1.43), all-cause death (HR, 1.20; 95% CI, 1.12-1.29), and any hospitalization (HR, 1.20; 95% CI, 1.15-1.25). Cumulative resting heart rate load demonstrated superior predictive value for all outcomes compared with baseline heart rate, mean heart rate, heart rate standard deviation, and heart rate time in the target range with improvements in C-statistics, net reclassification improvement, and integrated discrimination improvement when added to base models.</p><p><strong>Conclusions: </strong>Cumulative resting heart rate load provides stronger prognostic value for adverse outcomes in chronic HF. Incorporating this parameter into clinical practice may improve risk stratification and help identify high-risk patients who could benefit from intensive monitoring or therapeutic interventions.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Revista española de cardiología (English ed.)
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